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chr3:48,618,666-50,448,632

Best TWAS P=1.56e-08 · Best GWAS P=3.98e-07 conditioned to 0.955

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	GPX1	0.12	0.19	blup	275	0.19	1.3e-22	4.8	5.2	2.2e-07	0.94	0.08	0.91	FALSE
2	GTEx	Adipose Subcutaneous	TCTA	0.05	0.01	enet	10	0.01	5.8e-02	4.9	-5.3	1.3e-07	-0.88	0.05	0.77	FALSE
3	GTEx	Adipose Subcutaneous	NICN1	0.20	0.12	lasso	17	0.13	6.7e-11	4.7	-5.6	2.6e-08	-0.91	0.07	0.92	FALSE
4	GTEx	Adipose Subcutaneous	NICN1-AS1	0.16	0.14	enet	20	0.14	2.4e-11	4.7	-5.3	1.1e-07	-0.93	0.09	0.90	FALSE
5	GTEx	Artery Aorta	NICN1	0.15	0.21	enet	28	0.21	1.4e-11	5.0	-5.3	1.3e-07	-0.96	0.06	0.94	FALSE
6	GTEx	Artery Coronary	NICN1	0.10	0.01	lasso	13	0.01	1.3e-01	4.8	-5.4	8.2e-08	-0.91	0.05	0.60	FALSE
7	GTEx	Brain Cerebellum	GPX1	0.31	0.09	enet	19	0.23	2.0e-07	-4.1	5.5	3.9e-08	0.73	0.22	0.73	FALSE
8	GTEx	Cells EBV-transformed lymphocytes	USP4	0.08	0.05	lasso	2	0.09	8.7e-04	5.0	5.7	1.6e-08	0.90	0.07	0.72	TRUE
9	GTEx	Cells Transformed fibroblasts	TCTA	0.07	0.05	enet	14	0.07	9.4e-06	4.7	-5.4	6.1e-08	-0.61	0.06	0.82	FALSE
10	GTEx	Cells Transformed fibroblasts	NICN1	0.06	0.06	lasso	7	0.05	1.6e-04	5.1	-5.2	2.6e-07	-0.97	0.07	0.91	FALSE
11	GTEx	Esophagus Gastroesophageal Junction	RNF123	0.14	0.13	enet	30	0.10	2.3e-04	4.8	5.6	1.9e-08	0.73	0.08	0.88	FALSE
12	GTEx	Esophagus Muscularis	AMT	0.13	0.18	lasso	5	0.20	2.1e-12	4.8	-5.3	1.3e-07	-0.93	0.10	0.89	FALSE
13	GTEx	Esophagus Muscularis	NICN1	0.11	0.03	enet	22	0.07	2.7e-05	-3.9	-5.3	1.5e-07	-0.75	0.22	0.72	FALSE
14	GTEx	Esophagus Muscularis	GPX1	0.13	0.05	lasso	14	0.06	1.1e-04	-4.2	5.4	5.4e-08	0.73	0.18	0.78	FALSE
15	GTEx	Lung	NICN1	0.12	0.12	enet	13	0.15	2.6e-11	5.0	-5.5	4.4e-08	-0.96	0.05	0.95	FALSE
16	GTEx	Lung	NICN1-AS1	0.12	0.12	lasso	8	0.12	1.0e-09	4.8	-5.2	1.6e-07	-0.95	0.06	0.94	FALSE
17	GTEx	Nerve Tibial	NICN1	0.13	0.15	enet	21	0.16	1.4e-11	4.7	-5.4	5.2e-08	-0.90	0.08	0.91	FALSE
18	GTEx	Nerve Tibial	GPX1	0.05	0.01	enet	14	0.04	9.0e-04	4.9	5.3	1.1e-07	0.85	0.08	0.62	FALSE
19	GTEx	Nerve Tibial	NICN1-AS1	0.15	0.11	lasso	5	0.13	1.1e-09	4.7	-5.4	8.3e-08	-0.83	0.10	0.89	FALSE
20	GTEx	Stomach	AMT	0.13	0.14	enet	19	0.14	3.7e-07	5.0	-5.3	1.2e-07	-0.99	0.05	0.95	FALSE
21	GTEx	Thyroid	NICN1	0.27	0.33	lasso	13	0.34	5.6e-27	4.7	-5.2	2.3e-07	-0.95	0.11	0.88	FALSE
22	GTEx	Thyroid	GPX1	0.10	0.12	enet	23	0.11	9.1e-09	4.7	5.3	1.2e-07	0.92	0.10	0.89	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	GPX1	0.23	0.25	lasso	10	0.30	1.5e-39	4.8	5.5	4.6e-08	0.90	0.05	0.94	FALSE
24	The Cancer Genome Atlas	Breast Invasive Carcinoma	GMPPB	0.03	0.03	enet	12	0.03	3.0e-07	4.7	5.2	2.5e-07	0.61	0.01	0.98	FALSE
25	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	AMT	0.03	0.02	lasso	4	0.01	1.1e-02	4.7	-5.2	1.7e-07	-0.93	0.00	0.49	FALSE
26	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	GMPPB	0.13	0.08	blup	40	0.09	2.7e-04	4.7	5.5	4.2e-08	0.66	0.01	0.83	FALSE
27	The Cancer Genome Atlas	Thyroid Carcinoma	AMIGO3	0.08	0.07	blup	40	0.06	1.3e-06	4.7	5.3	1.3e-07	0.66	0.01	0.98	FALSE