Hub : Traits :

Medication: Paracetamol

401 significantly associated models · 36 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	1	173103273	175238653	3	1	3.5e-08	3.2e-10	1.000	100	RABGAP1L
2	1	242723236	244345666	2	1	5.1e-08	1.3e-07	0.118	91	SDCCAG8
3	3	48618666	50448632	9	1	1.6e-08	4.0e-07	0.955	100	USP4
4	6	96275538	97699026	1	1	1.2e-07	1.4e-08	0.036	86	KIAA0776
5	12	56838745	58303535	1	1	9.1e-15	1.1e-14	1.000	100	LRP1
6	17	42774693	45796313	19	1	2.8e-14	3.1e-14	1.000	100	CRHR1-IT1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Headache pain in last month	38.25	5	3	6.7	0.90	3.7e-02	CRHR1-IT1 KIAA0776 LRP1 RABGAP1L SDCCAG8
Medication: Paracetamol	26.69	6	6	13.3	0.99	5.5e-05	CRHR1-IT1 KIAA0776 LRP1 RABGAP1L SDCCAG8 USP4
Migraine (self-reported)	22.33	2	2	4.4	0.00	1.0e+00	KIAA0776 LRP1
Medication for pain relief, constipation, heartburn	21.09	5	5	11.1	-0.98	2.5e-03	CRHR1-IT1 KIAA0776 LRP1 RABGAP1L SDCCAG8
Hair/balding pattern: Pattern 4	17.14	1	1	2.2	0.00	1.0e+00	CRHR1-IT1
Medication: Ibuprofen (e.g. Nurofen)	15.04	3	1	2.2	0.00	1.0e+00	CRHR1-IT1 KIAA0776 LRP1
Depressed Affect (Nagel 2018)	14.08	3	2	4.4	0.00	1.0e+00	CRHR1-IT1 SDCCAG8 USP4
Pain experienced in last month	12.61	4	1	2.2	-0.98	2.2e-02	CRHR1-IT1 LRP1 RABGAP1L USP4
Neuroticism	11.91	3	1	2.2	0.00	1.0e+00	CRHR1-IT1 RABGAP1L USP4
Neuroticism (Nagel 2018)	11.84	3	1	2.2	0.00	1.0e+00	CRHR1-IT1 RABGAP1L USP4
Miserableness	11.70	3	2	4.4	0.00	1.0e+00	CRHR1-IT1 SDCCAG8 USP4
Medication: Ibuprofen	11.55	2	1	2.2	0.00	1.0e+00	CRHR1-IT1 LRP1
Relative age of first facial hair	10.95	1	1	2.2	0.00	1.0e+00	CRHR1-IT1
Sensitivity / hurt feelings	10.88	1	1	2.2	0.00	1.0e+00	CRHR1-IT1
Neuroticism score	10.34	3	1	2.2	0.00	1.0e+00	CRHR1-IT1 RABGAP1L USP4
Mood swings	10.09	2	2	4.4	0.00	1.0e+00	CRHR1-IT1 USP4
Fed-up feelings	9.84	2	2	4.4	0.00	1.0e+00	CRHR1-IT1 USP4
Qualifications: College or University degree	9.73	4	3	6.7	-0.95	4.7e-02	CRHR1-IT1 RABGAP1L SDCCAG8 USP4
Frequency of tenseness / restlessness in last 2 weeks	9.45	2	2	4.4	0.00	1.0e+00	CRHR1-IT1 USP4
Hair/balding pattern: Pattern 3	8.98	1	1	2.2	0.00	1.0e+00	CRHR1-IT1
Blood Red Count	8.88	2	2	4.4	0.00	1.0e+00	CRHR1-IT1 RABGAP1L
Number of treatments/medications taken	8.66	3	0	0.0	0.00	1.0e+00	LRP1 RABGAP1L SDCCAG8
Forced expiratory volume in 1-second (FEV1)	8.22	2	2	4.4	0.00	1.0e+00	CRHR1-IT1 USP4
Lung FVC	8.19	2	1	2.2	0.00	1.0e+00	CRHR1-IT1 USP4
Forced expiratory volume in 1-second (FEV1), Best measure	8.01	2	2	4.4	0.00	1.0e+00	CRHR1-IT1 USP4
Vitamin and mineral supplements	7.96	2	1	2.2	0.00	1.0e+00	CRHR1-IT1 LRP1
Overall health rating	7.57	2	2	4.4	0.00	1.0e+00	SDCCAG8 USP4
Neuroticism (2016)	7.44	1	1	2.2	0.00	1.0e+00	CRHR1-IT1
Qualifications: A levels/AS levels or equivalent	7.16	3	1	2.2	0.00	1.0e+00	CRHR1-IT1 SDCCAG8 USP4
Forced vital capacity (FVC)	7.11	2	1	2.2	0.00	1.0e+00	CRHR1-IT1 USP4
Forced vital capacity (FVC), Best measure	7.11	2	1	2.2	0.00	1.0e+00	CRHR1-IT1 USP4
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.89	1	1	2.2	0.00	1.0e+00	CRHR1-IT1
Ovarian Cancer	6.77	1	1	2.2	0.00	1.0e+00	CRHR1-IT1
Intelligence (Savage-Jansen 2018)	6.76	3	2	4.4	0.00	1.0e+00	CRHR1-IT1 RABGAP1L USP4
Relative age voice broke	6.75	1	1	2.2	0.00	1.0e+00	CRHR1-IT1
Exposure to tobacco smoke outside home	6.46	1	1	2.2	0.00	1.0e+00	SDCCAG8
Mouth/teeth dental problems: Mouth ulcers	6.38	2	1	2.2	0.00	1.0e+00	CRHR1-IT1 SDCCAG8
Frequency of tiredness / lethargy in last 2 weeks	6.23	1	1	2.2	0.00	1.0e+00	USP4
Worry (Nagel 2018)	6.19	2	1	2.2	0.00	1.0e+00	CRHR1-IT1 RABGAP1L
Qualifications: None of the above	6.13	2	1	2.2	0.00	1.0e+00	SDCCAG8 USP4
Lung FEV1/FVC ratio	5.99	2	1	2.2	0.00	1.0e+00	CRHR1-IT1 LRP1
Mouth/teeth dental problems	5.81	2	1	2.2	0.00	1.0e+00	CRHR1-IT1 SDCCAG8
Tense / 'highly strung'	5.74	1	1	2.2	0.00	1.0e+00	RABGAP1L
Irritable Bowel Disease (IBD)	5.65	1	1	2.2	0.00	1.0e+00	USP4
Ulcerative Colitis (UC)	5.53	1	1	2.2	0.00	1.0e+00	USP4
Neck or shoulder pain in last month	5.42	1	0	0.0	0.00	1.0e+00	USP4
Irritability	5.40	2	1	2.2	0.00	1.0e+00	CRHR1-IT1 USP4
Diastolic blood pressure, automated reading	5.40	1	1	2.2	0.00	1.0e+00	SDCCAG8
Ulcerative Colitis	5.39	1	1	2.2	0.00	1.0e+00	USP4
Alcohol intake frequency.	5.38	2	1	2.2	0.00	1.0e+00	CRHR1-IT1 LRP1
Knee pain experienced in last month	5.38	2	0	0.0	0.00	1.0e+00	RABGAP1L SDCCAG8
Ever unenthusiastic/disinterested for a whole week	5.37	1	0	0.0	0.00	1.0e+00	CRHR1-IT1
Loneliness, isolation	5.34	2	0	0.0	0.00	1.0e+00	CRHR1-IT1 USP4
Qualifications: O levels/GCSEs or equivalent	5.18	1	0	0.0	0.00	1.0e+00	USP4
Myopia	5.18	1	0	0.0	0.00	1.0e+00	LRP1
Average weekly champagne plus white wine intake	5.13	1	0	0.0	0.00	1.0e+00	CRHR1-IT1
Impedance of arm (left)	4.88	2	2	4.4	0.00	1.0e+00	CRHR1-IT1 USP4
Systolic blood pressure, automated reading	4.87	3	1	2.2	0.00	1.0e+00	CRHR1-IT1 KIAA0776 USP4
Primary Biliary Cirrhosis	4.82	2	0	0.0	0.00	1.0e+00	CRHR1-IT1 LRP1
Age at first live birth	4.82	1	1	2.2	0.00	1.0e+00	USP4
Breast Cancer	4.75	1	1	2.2	0.00	1.0e+00	CRHR1-IT1
Age when periods started (menarche)	4.68	1	1	2.2	0.00	1.0e+00	USP4
Waist Hip Ratio (WHR)	4.63	2	2	4.4	0.00	1.0e+00	CRHR1-IT1 USP4
Multivitamins +/- minerals	4.57	1	0	0.0	0.00	1.0e+00	LRP1
Guilty feelings	4.57	1	0	0.0	0.00	1.0e+00	CRHR1-IT1
Blood Eosinophil Count	4.52	3	2	4.4	0.00	1.0e+00	CRHR1-IT1 LRP1 USP4
Age at First Birth	4.40	1	0	0.0	0.00	1.0e+00	USP4
Age at last live birth	4.34	1	0	0.0	0.00	1.0e+00	USP4
Nervous feelings	4.33	1	1	2.2	0.00	1.0e+00	CRHR1-IT1
Peak expiratory flow (PEF)	4.33	1	1	2.2	0.00	1.0e+00	CRHR1-IT1
Verbal and Numeric Reasoning (VNR)	4.31	2	1	2.2	0.00	1.0e+00	CRHR1-IT1 USP4
Pack years adult smoking proportion	4.25	1	0	0.0	0.00	1.0e+00	USP4
Respiratory disease	4.24	2	1	2.2	0.00	1.0e+00	LRP1 RABGAP1L
Smoking Status	4.16	1	1	2.2	0.00	1.0e+00	USP4
Qualifications: nursing, teaching	4.11	1	0	0.0	0.00	1.0e+00	SDCCAG8
Sitting height	4.03	2	2	4.4	0.00	1.0e+00	CRHR1-IT1 LRP1
Schizophrenia vs Biploar Disorder	4.00	1	0	0.0	0.00	1.0e+00	CRHR1-IT1
Impedance of arm (right)	3.99	2	2	4.4	0.00	1.0e+00	CRHR1-IT1 USP4
Frequency of depressed mood in last 2 weeks	3.97	1	0	0.0	0.00	1.0e+00	CRHR1-IT1
Handedness (chirality/laterality): Left-handed	3.97	1	0	0.0	0.00	1.0e+00	CRHR1-IT1
Taking other prescription medications	3.95	1	0	0.0	0.00	1.0e+00	USP4
Depression (Nagel 2018)	3.92	1	0	0.0	0.00	1.0e+00	CRHR1-IT1
Impedance of whole body	3.86	2	2	4.4	0.00	1.0e+00	CRHR1-IT1 USP4
Worrier / anxious feelings	3.83	1	1	2.2	0.00	1.0e+00	CRHR1-IT1
Hair/balding pattern: Pattern 2	3.78	1	0	0.0	0.00	1.0e+00	CRHR1-IT1
Fluid intelligence score	3.66	1	0	0.0	0.00	1.0e+00	CRHR1-IT1
Worry too long after embarrassment	3.65	1	0	0.0	0.00	1.0e+00	CRHR1-IT1
Mineral and other dietary supplements	3.61	1	0	0.0	0.00	1.0e+00	LRP1
Alcohol usually taken with meals	3.57	1	0	0.0	0.00	1.0e+00	RABGAP1L
Financial situation satisfaction	3.56	1	0	0.0	0.00	1.0e+00	USP4
Systolic Blood Pressure	3.53	3	2	4.4	0.00	1.0e+00	CRHR1-IT1 KIAA0776 SDCCAG8
Leg fat percentage (right)	3.49	2	0	0.0	0.00	1.0e+00	LRP1 USP4
Asthma (self-reported)	3.49	1	0	0.0	0.00	1.0e+00	LRP1
Crohns Disease (2017)	3.46	1	1	2.2	0.00	1.0e+00	USP4
Leg fat percentage (left)	3.44	3	0	0.0	0.00	1.0e+00	LRP1 SDCCAG8 USP4
Hayfever/allergic rhinitis (self-reported)	3.43	1	0	0.0	0.00	1.0e+00	LRP1
Asthma	3.43	1	0	0.0	0.00	1.0e+00	LRP1
Pack years of smoking	3.41	1	0	0.0	0.00	1.0e+00	USP4
Hand grip strength (left)	3.39	1	1	2.2	0.00	1.0e+00	CRHR1-IT1
Pain all over the body in last month	3.37	1	0	0.0	0.00	1.0e+00	USP4
Hand grip strength (right)	3.35	2	1	2.2	0.00	1.0e+00	CRHR1-IT1 LRP1
Mother's age at death	3.20	1	0	0.0	0.00	1.0e+00	SDCCAG8
Father's age at death	3.19	1	0	0.0	0.00	1.0e+00	USP4
Supplements: Fish oil (including cod liver oil)	3.18	1	0	0.0	0.00	1.0e+00	LRP1
Major Depression (MDD)	3.17	1	0	0.0	0.00	1.0e+00	USP4
Chest pain or discomfort	2.88	1	0	0.0	0.00	1.0e+00	USP4
Leg fat mass (right)	2.84	2	0	0.0	0.00	1.0e+00	SDCCAG8 USP4
Leg fat mass (left)	2.82	2	0	0.0	0.00	1.0e+00	SDCCAG8 USP4
Body mass index (BMI)	2.77	1	1	2.2	0.00	1.0e+00	USP4
BMI	2.73	3	1	2.2	0.00	1.0e+00	LRP1 RABGAP1L USP4
Medication: Blood pressure	2.61	1	0	0.0	0.00	1.0e+00	CRHR1-IT1
Body fat percentage	2.58	2	0	0.0	0.00	1.0e+00	LRP1 SDCCAG8
High blood pressure	2.57	1	0	0.0	0.00	1.0e+00	SDCCAG8
Trunk fat percentage	2.56	2	0	0.0	0.00	1.0e+00	CRHR1-IT1 SDCCAG8
Heel T-Score	2.50	1	1	2.2	0.00	1.0e+00	CRHR1-IT1
Hearing difficulty/problems with background noise	2.48	1	0	0.0	0.00	1.0e+00	CRHR1-IT1
Ever smoked	2.47	1	0	0.0	0.00	1.0e+00	USP4
Number of live births	2.46	1	0	0.0	0.00	1.0e+00	CRHR1-IT1
Current tobacco smoking	2.43	1	0	0.0	0.00	1.0e+00	USP4
Hypertension (Self-reported)	2.41	1	0	0.0	0.00	1.0e+00	SDCCAG8
Smoking status: Current	2.21	1	0	0.0	0.00	1.0e+00	USP4
Whole body fat mass	2.16	2	0	0.0	0.00	1.0e+00	SDCCAG8 USP4
Chronotype (morning person)	2.13	1	0	0.0	0.00	1.0e+00	USP4
Vascular/heart problems diagnosed by doctor	2.12	1	0	0.0	0.00	1.0e+00	SDCCAG8
Trunk fat mass	2.03	2	0	0.0	0.00	1.0e+00	CRHR1-IT1 SDCCAG8
Allergy	2.02	1	0	0.0	0.00	1.0e+00	LRP1
Arm fat mass (right)	2.01	2	0	0.0	0.00	1.0e+00	SDCCAG8 USP4
Hip circumference	1.86	1	0	0.0	0.00	1.0e+00	USP4
Arm fat mass (left)	1.84	2	0	0.0	0.00	1.0e+00	SDCCAG8 USP4
Allergy or Eczema	1.77	1	0	0.0	0.00	1.0e+00	LRP1
Impedance of leg (left)	1.77	2	0	0.0	0.00	1.0e+00	CRHR1-IT1 USP4
Cardiovascular Disease	1.74	1	0	0.0	0.00	1.0e+00	SDCCAG8
Blood White Count	1.66	3	1	2.2	0.00	1.0e+00	CRHR1-IT1 SDCCAG8 USP4
Waist circumference	1.61	1	0	0.0	0.00	1.0e+00	SDCCAG8
Height	1.59	3	3	6.7	0.00	1.0e+00	CRHR1-IT1 LRP1 USP4
Arm fat-free mass (left)	1.59	1	0	0.0	0.00	1.0e+00	USP4
Arm predicted mass (left)	1.58	2	0	0.0	0.00	1.0e+00	RABGAP1L USP4
Impedance of leg (right)	1.57	2	0	0.0	0.00	1.0e+00	CRHR1-IT1 USP4
Weight	1.55	1	0	0.0	0.00	1.0e+00	USP4
Standing height	1.48	2	2	4.4	0.00	1.0e+00	CRHR1-IT1 LRP1
Arm predicted mass (right)	1.39	1	0	0.0	0.00	1.0e+00	USP4
Hayfever, allergic rhinitis or eczema	1.37	1	0	0.0	0.00	1.0e+00	LRP1
Trunk fat-free mass	1.36	2	0	0.0	0.00	1.0e+00	LRP1 RABGAP1L
Comparative height size at age 10	1.36	1	1	2.2	0.00	1.0e+00	CRHR1-IT1
Trunk predicted mass	1.33	2	0	0.0	0.00	1.0e+00	LRP1 RABGAP1L
Arm fat-free mass (right)	1.27	1	0	0.0	0.00	1.0e+00	USP4
Blood Platelet Count	0.95	1	1	2.2	0.00	1.0e+00	CRHR1-IT1
Hair Pigment	0.27	2	0	0.0	0.00	1.0e+00	CRHR1-IT1 LRP1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Artery Coronary	9	0.761	2.0
GTEx	Uterus	6	1.058	2.0
GTEx	Brain Hippocampus	4	0.763	1.9
GTEx	Brain Putamen basal ganglia	6	0.962	1.9
GTEx	Ovary	6	0.661	1.9
GTEx	Small Intestine Terminal Ileum	4	0.868	1.9
GTEx	Vagina	5	0.787	1.9
GTEx	Brain Hypothalamus	4	0.678	1.8
GTEx	Colon Sigmoid	7	0.479	1.8
GTEx	Prostate	4	0.479	1.8
GTEx	Stomach	8	0.550	1.8
GTEx	Adipose Visceral Omentum	6	0.295	1.7
GTEx	Artery Aorta	9	0.302	1.7
GTEx	Brain Cerebellum	7	0.353	1.7
GTEx	Brain Cortex	6	0.580	1.7
GTEx	Brain Frontal Cortex BA9	5	0.541	1.7
GTEx	Brain Nucleus accumbens basal ganglia	6	0.694	1.7
GTEx	Breast Mammary Tissue	7	0.355	1.7
GTEx	Breast Mammary Tissue (Male)	7	0.587	1.7
GTEx	Breast Mammary Tissue (Female)	7	0.426	1.7
GTEx	Cells EBV-transformed lymphocytes	9	0.632	1.7
GTEx	Colon Transverse	8	0.388	1.7
GTEx	Esophagus Gastroesophageal Junction	8	0.554	1.7
GTEx	Pancreas	7	0.429	1.7
GTEx	Pituitary	5	0.448	1.7
GTEx	Skin Not Sun Exposed Suprapubic	8	0.325	1.7
GTEx	Spleen	5	0.354	1.7
GTEx	Adipose Subcutaneous	9	0.258	1.6
GTEx	Adrenal Gland	5	0.343	1.6
GTEx	Artery Tibial	6	0.160	1.6
GTEx	Brain Caudate basal ganglia	5	0.543	1.6
GTEx	Brain Cerebellar Hemisphere	6	0.403	1.6
GTEx	Cells Transformed fibroblasts	11	0.262	1.6
GTEx	Esophagus Mucosa	10	0.301	1.6
GTEx	Esophagus Muscularis	12	0.371	1.6
GTEx	Heart Atrial Appendage	7	0.443	1.6
GTEx	Heart Left Ventricle	7	0.458	1.6
GTEx	Liver	4	0.558	1.6
GTEx	Lung	11	0.383	1.6
GTEx	Muscle Skeletal	8	0.277	1.6
GTEx	Skin Sun Exposed Lower leg	9	0.247	1.6
GTEx	Testis	10	0.317	1.6
GTEx	Thyroid	11	0.275	1.6
GTEx	Whole Blood	6	0.301	1.6
The Cancer Genome Atlas	Esophageal Carcinoma	4	0.584	1.6
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.187	1.6
GTEx	Nerve Tibial	10	0.231	1.5
NTR	Blood	4	0.167	1.5
ROSMAP	Brain Pre-frontal Cortex	1	0.023	1.5
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	3	0.181	1.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	3	0.273	1.5
The Cancer Genome Atlas	Glioblastoma Multiforme	0	0.000	1.5
The Cancer Genome Atlas	Lung Adenocarcinoma	4	0.136	1.5
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	5	0.200	1.5
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	2	0.120	1.5
The Cancer Genome Atlas	Rectum Adenocarcinoma	3	0.434	1.5
The Cancer Genome Atlas	Soft Tissue Sarcoma	3	0.281	1.5
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	2	0.394	1.5
METSIM	Adipose	1	0.022	1.4
YFS	Blood	0	0.000	1.4
CommonMind	Brain Pre-frontal Cortex	3	0.056	1.4
The Cancer Genome Atlas	Breast Invasive Carcinoma	3	0.068	1.4
The Cancer Genome Atlas	Colon Adenocarcinoma	1	0.048	1.4
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	3	0.110	1.4
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	5	0.122	1.4
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	2	0.098	1.4
The Cancer Genome Atlas	Brain Lower Grade Glioma	4	0.093	1.4
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	3	0.271	1.4
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	3	0.188	1.4
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	4	0.301	1.4
The Cancer Genome Atlas	Prostate Adenocarcinoma	5	0.108	1.4
The Cancer Genome Atlas	Stomach Adenocarcinoma	3	0.178	1.4
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.4
The Cancer Genome Atlas	Thyroid Carcinoma	5	0.097	1.4