Hub : Traits :

Medication: Paracetamol

401 significantly associated models · 36 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 1 173103273 175238653 3 1 3.5e-08 3.2e-10 1.000 100 RABGAP1L
2 1 242723236 244345666 2 1 5.1e-08 1.3e-07 0.118 91 SDCCAG8
3 3 48618666 50448632 9 1 1.6e-08 4.0e-07 0.955 100 USP4
4 6 96275538 97699026 1 1 1.2e-07 1.4e-08 0.036 86 KIAA0776
5 12 56838745 58303535 1 1 9.1e-15 1.1e-14 1.000 100 LRP1
6 17 42774693 45796313 19 1 2.8e-14 3.1e-14 1.000 100 CRHR1-IT1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 14.08 3 2 4.4 0.00 1.0e+00 CRHR1-IT1 SDCCAG8 USP4
Depression (Nagel 2018) 3.92 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Intelligence (Savage-Jansen 2018) 6.76 3 2 4.4 0.00 1.0e+00 CRHR1-IT1 RABGAP1L USP4
Neuroticism (Nagel 2018) 11.84 3 1 2.2 0.00 1.0e+00 CRHR1-IT1 RABGAP1L USP4
Schizophrenia vs Biploar Disorder 4.00 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Worry (Nagel 2018) 6.19 2 1 2.2 0.00 1.0e+00 CRHR1-IT1 RABGAP1L
Crohns Disease (2017) 3.46 1 1 2.2 0.00 1.0e+00 USP4
Irritable Bowel Disease (IBD) 5.65 1 1 2.2 0.00 1.0e+00 USP4
Ulcerative Colitis (UC) 5.53 1 1 2.2 0.00 1.0e+00 USP4
Major Depression (MDD) 3.17 1 0 0.0 0.00 1.0e+00 USP4
Verbal and Numeric Reasoning (VNR) 4.31 2 1 2.2 0.00 1.0e+00 CRHR1-IT1 USP4
Breast Cancer 4.75 1 1 2.2 0.00 1.0e+00 CRHR1-IT1
Ovarian Cancer 6.77 1 1 2.2 0.00 1.0e+00 CRHR1-IT1
Age at First Birth 4.40 1 0 0.0 0.00 1.0e+00 USP4
Neuroticism (2016) 7.44 1 1 2.2 0.00 1.0e+00 CRHR1-IT1
Primary Biliary Cirrhosis 4.82 2 0 0.0 0.00 1.0e+00 CRHR1-IT1 LRP1
Ulcerative Colitis 5.39 1 1 2.2 0.00 1.0e+00 USP4
Blood Eosinophil Count 4.52 3 2 4.4 0.00 1.0e+00 CRHR1-IT1 LRP1 USP4
Blood Platelet Count 0.95 1 1 2.2 0.00 1.0e+00 CRHR1-IT1
Blood Red Count 8.88 2 2 4.4 0.00 1.0e+00 CRHR1-IT1 RABGAP1L
Blood White Count 1.66 3 1 2.2 0.00 1.0e+00 CRHR1-IT1 SDCCAG8 USP4
Heel T-Score 2.50 1 1 2.2 0.00 1.0e+00 CRHR1-IT1
BMI 2.73 3 1 2.2 0.00 1.0e+00 LRP1 RABGAP1L USP4
Height 1.59 3 3 6.7 0.00 1.0e+00 CRHR1-IT1 LRP1 USP4
Waist Hip Ratio (WHR) 4.63 2 2 4.4 0.00 1.0e+00 CRHR1-IT1 USP4
Systolic Blood Pressure 3.53 3 2 4.4 0.00 1.0e+00 CRHR1-IT1 KIAA0776 SDCCAG8
Smoking Status 4.16 1 1 2.2 0.00 1.0e+00 USP4
Allergy or Eczema 1.77 1 0 0.0 0.00 1.0e+00 LRP1
Cardiovascular Disease 1.74 1 0 0.0 0.00 1.0e+00 SDCCAG8
Respiratory disease 4.24 2 1 2.2 0.00 1.0e+00 LRP1 RABGAP1L
Lung FEV1/FVC ratio 5.99 2 1 2.2 0.00 1.0e+00 CRHR1-IT1 LRP1
Lung FVC 8.19 2 1 2.2 0.00 1.0e+00 CRHR1-IT1 USP4
Neuroticism 11.91 3 1 2.2 0.00 1.0e+00 CRHR1-IT1 RABGAP1L USP4
Chronotype (morning person) 2.13 1 0 0.0 0.00 1.0e+00 USP4
Hair Pigment 0.27 2 0 0.0 0.00 1.0e+00 CRHR1-IT1 LRP1
Hand grip strength (left) 3.39 1 1 2.2 0.00 1.0e+00 CRHR1-IT1
Number of treatments/medications taken 8.66 3 0 0.0 0.00 1.0e+00 LRP1 RABGAP1L SDCCAG8
Sensitivity / hurt feelings 10.88 1 1 2.2 0.00 1.0e+00 CRHR1-IT1
Frequency of depressed mood in last 2 weeks 3.97 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Relative age of first facial hair 10.95 1 1 2.2 0.00 1.0e+00 CRHR1-IT1
Systolic blood pressure, automated reading 4.87 3 1 2.2 0.00 1.0e+00 CRHR1-IT1 KIAA0776 USP4
Vitamin and mineral supplements 7.96 2 1 2.2 0.00 1.0e+00 CRHR1-IT1 LRP1
Pack years adult smoking proportion 4.25 1 0 0.0 0.00 1.0e+00 USP4
Impedance of leg (right) 1.57 2 0 0.0 0.00 1.0e+00 CRHR1-IT1 USP4
Trunk fat percentage 2.56 2 0 0.0 0.00 1.0e+00 CRHR1-IT1 SDCCAG8
Hand grip strength (right) 3.35 2 1 2.2 0.00 1.0e+00 CRHR1-IT1 LRP1
Current tobacco smoking 2.43 1 0 0.0 0.00 1.0e+00 USP4
Fed-up feelings 9.84 2 2 4.4 0.00 1.0e+00 CRHR1-IT1 USP4
Relative age voice broke 6.75 1 1 2.2 0.00 1.0e+00 CRHR1-IT1
Taking other prescription medications 3.95 1 0 0.0 0.00 1.0e+00 USP4
Age when periods started (menarche) 4.68 1 1 2.2 0.00 1.0e+00 USP4
High blood pressure 2.57 1 0 0.0 0.00 1.0e+00 SDCCAG8
Hayfever, allergic rhinitis or eczema 1.37 1 0 0.0 0.00 1.0e+00 LRP1
Multivitamins +/- minerals 4.57 1 0 0.0 0.00 1.0e+00 LRP1
Sitting height 4.03 2 2 4.4 0.00 1.0e+00 CRHR1-IT1 LRP1
Body mass index (BMI) 2.77 1 1 2.2 0.00 1.0e+00 USP4
Impedance of leg (left) 1.77 2 0 0.0 0.00 1.0e+00 CRHR1-IT1 USP4
Trunk fat mass 2.03 2 0 0.0 0.00 1.0e+00 CRHR1-IT1 SDCCAG8
Waist circumference 1.61 1 0 0.0 0.00 1.0e+00 SDCCAG8
Alcohol usually taken with meals 3.57 1 0 0.0 0.00 1.0e+00 RABGAP1L
Nervous feelings 4.33 1 1 2.2 0.00 1.0e+00 CRHR1-IT1
Frequency of tenseness / restlessness in last 2 weeks 9.45 2 2 4.4 0.00 1.0e+00 CRHR1-IT1 USP4
Hearing difficulty/problems with background noise 2.48 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Hair/balding pattern: Pattern 2 3.78 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Forced vital capacity (FVC) 7.11 2 1 2.2 0.00 1.0e+00 CRHR1-IT1 USP4
Ever unenthusiastic/disinterested for a whole week 5.37 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Qualifications: None of the above 6.13 2 1 2.2 0.00 1.0e+00 SDCCAG8 USP4
Mouth/teeth dental problems 5.81 2 1 2.2 0.00 1.0e+00 CRHR1-IT1 SDCCAG8
Allergy 2.02 1 0 0.0 0.00 1.0e+00 LRP1
Pain all over the body in last month 3.37 1 0 0.0 0.00 1.0e+00 USP4
Hayfever/allergic rhinitis (self-reported) 3.43 1 0 0.0 0.00 1.0e+00 LRP1
Fluid intelligence score 3.66 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Neuroticism score 10.34 3 1 2.2 0.00 1.0e+00 CRHR1-IT1 RABGAP1L USP4
Weight 1.55 1 0 0.0 0.00 1.0e+00 USP4
Impedance of arm (right) 3.99 2 2 4.4 0.00 1.0e+00 CRHR1-IT1 USP4
Trunk fat-free mass 1.36 2 0 0.0 0.00 1.0e+00 LRP1 RABGAP1L
Hip circumference 1.86 1 0 0.0 0.00 1.0e+00 USP4
Father's age at death 3.19 1 0 0.0 0.00 1.0e+00 USP4
Worrier / anxious feelings 3.83 1 1 2.2 0.00 1.0e+00 CRHR1-IT1
Frequency of tiredness / lethargy in last 2 weeks 6.23 1 1 2.2 0.00 1.0e+00 USP4
Hair/balding pattern: Pattern 3 8.98 1 1 2.2 0.00 1.0e+00 CRHR1-IT1
Number of live births 2.46 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Forced expiratory volume in 1-second (FEV1) 8.22 2 2 4.4 0.00 1.0e+00 CRHR1-IT1 USP4
Qualifications: A levels/AS levels or equivalent 7.16 3 1 2.2 0.00 1.0e+00 CRHR1-IT1 SDCCAG8 USP4
Asthma 3.43 1 0 0.0 0.00 1.0e+00 LRP1
Medication: Ibuprofen (e.g. Nurofen) 15.04 3 1 2.2 0.00 1.0e+00 CRHR1-IT1 KIAA0776 LRP1
Forced expiratory volume in 1-second (FEV1), Best measure 8.01 2 2 4.4 0.00 1.0e+00 CRHR1-IT1 USP4
Impedance of arm (left) 4.88 2 2 4.4 0.00 1.0e+00 CRHR1-IT1 USP4
Arm fat mass (right) 2.01 2 0 0.0 0.00 1.0e+00 SDCCAG8 USP4
Trunk predicted mass 1.33 2 0 0.0 0.00 1.0e+00 LRP1 RABGAP1L
Standing height 1.48 2 2 4.4 0.00 1.0e+00 CRHR1-IT1 LRP1
Tense / 'highly strung' 5.74 1 1 2.2 0.00 1.0e+00 RABGAP1L
Hair/balding pattern: Pattern 4 17.14 1 1 2.2 0.00 1.0e+00 CRHR1-IT1
Peak expiratory flow (PEF) 4.33 1 1 2.2 0.00 1.0e+00 CRHR1-IT1
Qualifications: O levels/GCSEs or equivalent 5.18 1 0 0.0 0.00 1.0e+00 USP4
Medication: Paracetamol 26.69 6 6 13.3 0.99 5.5e-05 CRHR1-IT1 KIAA0776 LRP1 RABGAP1L SDCCAG8 USP4
Headache pain in last month 38.25 5 3 6.7 0.90 3.7e-02 CRHR1-IT1 KIAA0776 LRP1 RABGAP1L SDCCAG8
Forced vital capacity (FVC), Best measure 7.11 2 1 2.2 0.00 1.0e+00 CRHR1-IT1 USP4
Body fat percentage 2.58 2 0 0.0 0.00 1.0e+00 LRP1 SDCCAG8
Leg fat percentage (right) 3.49 2 0 0.0 0.00 1.0e+00 LRP1 USP4
Arm fat-free mass (right) 1.27 1 0 0.0 0.00 1.0e+00 USP4
Exposure to tobacco smoke outside home 6.46 1 1 2.2 0.00 1.0e+00 SDCCAG8
Worry too long after embarrassment 3.65 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Age at first live birth 4.82 1 1 2.2 0.00 1.0e+00 USP4
Qualifications: College or University degree 9.73 4 3 6.7 -0.95 4.7e-02 CRHR1-IT1 RABGAP1L SDCCAG8 USP4
Medication for pain relief, constipation, heartburn 21.09 5 5 11.1 -0.98 2.5e-03 CRHR1-IT1 KIAA0776 LRP1 RABGAP1L SDCCAG8
Neck or shoulder pain in last month 5.42 1 0 0.0 0.00 1.0e+00 USP4
Migraine (self-reported) 22.33 2 2 4.4 0.00 1.0e+00 KIAA0776 LRP1
Medication: Ibuprofen 11.55 2 1 2.2 0.00 1.0e+00 CRHR1-IT1 LRP1
Whole body fat mass 2.16 2 0 0.0 0.00 1.0e+00 SDCCAG8 USP4
Leg fat mass (right) 2.84 2 0 0.0 0.00 1.0e+00 SDCCAG8 USP4
Arm predicted mass (right) 1.39 1 0 0.0 0.00 1.0e+00 USP4
Alcohol intake frequency. 5.38 2 1 2.2 0.00 1.0e+00 CRHR1-IT1 LRP1
Comparative height size at age 10 1.36 1 1 2.2 0.00 1.0e+00 CRHR1-IT1
Overall health rating 7.57 2 2 4.4 0.00 1.0e+00 SDCCAG8 USP4
Chest pain or discomfort 2.88 1 0 0.0 0.00 1.0e+00 USP4
Age at last live birth 4.34 1 0 0.0 0.00 1.0e+00 USP4
Knee pain experienced in last month 5.38 2 0 0.0 0.00 1.0e+00 RABGAP1L SDCCAG8
Hypertension (Self-reported) 2.41 1 0 0.0 0.00 1.0e+00 SDCCAG8
Handedness (chirality/laterality): Left-handed 3.97 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Mood swings 10.09 2 2 4.4 0.00 1.0e+00 CRHR1-IT1 USP4
Loneliness, isolation 5.34 2 0 0.0 0.00 1.0e+00 CRHR1-IT1 USP4
Qualifications: nursing, teaching 4.11 1 0 0.0 0.00 1.0e+00 SDCCAG8
Mouth/teeth dental problems: Mouth ulcers 6.38 2 1 2.2 0.00 1.0e+00 CRHR1-IT1 SDCCAG8
Mineral and other dietary supplements 3.61 1 0 0.0 0.00 1.0e+00 LRP1
Asthma (self-reported) 3.49 1 0 0.0 0.00 1.0e+00 LRP1
Smoking status: Current 2.21 1 0 0.0 0.00 1.0e+00 USP4
Forced expiratory volume in 1-second (FEV1), predicted percentage 6.89 1 1 2.2 0.00 1.0e+00 CRHR1-IT1
Arm fat mass (left) 1.84 2 0 0.0 0.00 1.0e+00 SDCCAG8 USP4
Average weekly champagne plus white wine intake 5.13 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Miserableness 11.70 3 2 4.4 0.00 1.0e+00 CRHR1-IT1 SDCCAG8 USP4
Guilty feelings 4.57 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Mother's age at death 3.20 1 0 0.0 0.00 1.0e+00 SDCCAG8
Financial situation satisfaction 3.56 1 0 0.0 0.00 1.0e+00 USP4
Medication: Blood pressure 2.61 1 0 0.0 0.00 1.0e+00 CRHR1-IT1
Supplements: Fish oil (including cod liver oil) 3.18 1 0 0.0 0.00 1.0e+00 LRP1
Ever smoked 2.47 1 0 0.0 0.00 1.0e+00 USP4
Leg fat percentage (left) 3.44 3 0 0.0 0.00 1.0e+00 LRP1 SDCCAG8 USP4
Arm fat-free mass (left) 1.59 1 0 0.0 0.00 1.0e+00 USP4
Irritability 5.40 2 1 2.2 0.00 1.0e+00 CRHR1-IT1 USP4
Diastolic blood pressure, automated reading 5.40 1 1 2.2 0.00 1.0e+00 SDCCAG8
Myopia 5.18 1 0 0.0 0.00 1.0e+00 LRP1
Vascular/heart problems diagnosed by doctor 2.12 1 0 0.0 0.00 1.0e+00 SDCCAG8
Pain experienced in last month 12.61 4 1 2.2 -0.98 2.2e-02 CRHR1-IT1 LRP1 RABGAP1L USP4
Pack years of smoking 3.41 1 0 0.0 0.00 1.0e+00 USP4
Impedance of whole body 3.86 2 2 4.4 0.00 1.0e+00 CRHR1-IT1 USP4
Leg fat mass (left) 2.82 2 0 0.0 0.00 1.0e+00 SDCCAG8 USP4
Arm predicted mass (left) 1.58 2 0 0.0 0.00 1.0e+00 RABGAP1L USP4

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 9 0.258 1.6
GTEx Adipose Visceral Omentum 6 0.295 1.7
GTEx Adrenal Gland 5 0.343 1.6
GTEx Artery Aorta 9 0.302 1.7
GTEx Artery Coronary 9 0.761 2.0
GTEx Artery Tibial 6 0.160 1.6
GTEx Brain Caudate basal ganglia 5 0.543 1.6
GTEx Brain Cerebellar Hemisphere 6 0.403 1.6
GTEx Brain Cerebellum 7 0.353 1.7
GTEx Brain Cortex 6 0.580 1.7
GTEx Brain Frontal Cortex BA9 5 0.541 1.7
GTEx Brain Hippocampus 4 0.763 1.9
GTEx Brain Hypothalamus 4 0.678 1.8
GTEx Brain Nucleus accumbens basal ganglia 6 0.694 1.7
GTEx Brain Putamen basal ganglia 6 0.962 1.9
GTEx Breast Mammary Tissue 7 0.355 1.7
GTEx Breast Mammary Tissue (Male) 7 0.587 1.7
GTEx Breast Mammary Tissue (Female) 7 0.426 1.7
GTEx Cells EBV-transformed lymphocytes 9 0.632 1.7
GTEx Cells Transformed fibroblasts 11 0.262 1.6
GTEx Colon Sigmoid 7 0.479 1.8
GTEx Colon Transverse 8 0.388 1.7
GTEx Esophagus Gastroesophageal Junction 8 0.554 1.7
GTEx Esophagus Mucosa 10 0.301 1.6
GTEx Esophagus Muscularis 12 0.371 1.6
GTEx Heart Atrial Appendage 7 0.443 1.6
GTEx Heart Left Ventricle 7 0.458 1.6
GTEx Liver 4 0.558 1.6
GTEx Lung 11 0.383 1.6
GTEx Muscle Skeletal 8 0.277 1.6
GTEx Nerve Tibial 10 0.231 1.5
GTEx Ovary 6 0.661 1.9
GTEx Pancreas 7 0.429 1.7
GTEx Pituitary 5 0.448 1.7
GTEx Prostate 4 0.479 1.8
GTEx Skin Not Sun Exposed Suprapubic 8 0.325 1.7
GTEx Skin Sun Exposed Lower leg 9 0.247 1.6
GTEx Small Intestine Terminal Ileum 4 0.868 1.9
GTEx Spleen 5 0.354 1.7
GTEx Stomach 8 0.550 1.8
GTEx Testis 10 0.317 1.6
GTEx Thyroid 11 0.275 1.6
GTEx Uterus 6 1.058 2.0
GTEx Vagina 5 0.787 1.9
GTEx Whole Blood 6 0.301 1.6
METSIM Adipose 1 0.022 1.4
NTR Blood 4 0.167 1.5
ROSMAP Brain Pre-frontal Cortex 1 0.023 1.5
YFS Blood 0 0.000 1.4
CommonMind Brain Pre-frontal Cortex 3 0.056 1.4
The Cancer Genome Atlas Bladder Urothelial Carcinoma 3 0.181 1.5
The Cancer Genome Atlas Breast Invasive Carcinoma 3 0.068 1.4
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 3 0.273 1.5
The Cancer Genome Atlas Colon Adenocarcinoma 1 0.048 1.4
The Cancer Genome Atlas Esophageal Carcinoma 4 0.584 1.6
The Cancer Genome Atlas Glioblastoma Multiforme 0 0.000 1.5
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 3 0.110 1.4
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 5 0.122 1.4
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 2 0.098 1.4
The Cancer Genome Atlas Brain Lower Grade Glioma 4 0.093 1.4
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 3 0.271 1.4
The Cancer Genome Atlas Lung Adenocarcinoma 4 0.136 1.5
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 5 0.200 1.5
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 3 0.188 1.4
The Cancer Genome Atlas Pancreatic Adenocarcinoma 2 0.120 1.5
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 4 0.301 1.4
The Cancer Genome Atlas Prostate Adenocarcinoma 5 0.108 1.4
The Cancer Genome Atlas Rectum Adenocarcinoma 3 0.434 1.5
The Cancer Genome Atlas Soft Tissue Sarcoma 3 0.281 1.5
The Cancer Genome Atlas Skin Cutaneous Melanoma 1 0.187 1.6
The Cancer Genome Atlas Stomach Adenocarcinoma 3 0.178 1.4
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.078 1.4
The Cancer Genome Atlas Thyroid Carcinoma 5 0.097 1.4
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 2 0.394 1.5