Best TWAS P=5.96e-68 · Best GWAS P=7.92e-63 conditioned to 0.0516
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | CDK6 | 0.12 | 0.10 | lasso | 2 | 0.10 | 1.9e-12 | 16.57 | 16.6 | 1.0e-61 | 1.00 | 0.01 | 0.99 | FALSE |
| 2 | GTEx | Adipose Subcutaneous | GATAD1 | 0.21 | 0.14 | enet | 10 | 0.16 | 3.4e-13 | 9.39 | -7.9 | 2.0e-15 | -0.37 | 1.00 | 0.00 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | GATAD1 | 0.12 | 0.08 | lasso | 5 | 0.06 | 7.5e-04 | 9.39 | -9.4 | 4.3e-21 | -0.46 | 0.82 | 0.06 | FALSE |
| 4 | GTEx | Adrenal Gland | GATAD1 | 0.40 | 0.22 | lasso | 7 | 0.25 | 2.0e-09 | 9.39 | -10.1 | 8.8e-24 | -0.47 | 0.67 | 0.08 | FALSE |
| 5 | GTEx | Artery Aorta | KRIT1 | 0.15 | 0.00 | enet | 24 | 0.03 | 1.3e-02 | 1.35 | -7.2 | 6.5e-13 | -0.28 | 0.12 | 0.05 | FALSE |
| 6 | GTEx | Artery Aorta | GATAD1 | 0.09 | 0.08 | enet | 4 | 0.07 | 7.4e-05 | 9.39 | -8.9 | 5.1e-19 | -0.42 | 0.52 | 0.05 | FALSE |
| 7 | GTEx | Artery Coronary | GATAD1 | 0.12 | 0.15 | lasso | 3 | 0.12 | 8.0e-05 | 9.18 | -9.6 | 1.3e-21 | -0.41 | 0.19 | 0.20 | FALSE |
| 8 | GTEx | Artery Tibial | GATAD1 | 0.14 | 0.04 | enet | 17 | 0.04 | 4.1e-04 | 9.39 | -9.0 | 2.2e-19 | -0.38 | 0.71 | 0.10 | FALSE |
| 9 | GTEx | Artery Tibial | AC007566.10 | 0.13 | 0.04 | lasso | 5 | 0.00 | 3.1e-01 | 5.04 | -6.2 | 5.2e-10 | -0.15 | 0.08 | 0.04 | FALSE |
| 10 | GTEx | Brain Caudate basal ganglia | GATAD1 | 0.21 | 0.09 | lasso | 4 | 0.08 | 2.3e-03 | 6.61 | -10.1 | 5.0e-24 | -0.43 | 0.08 | 0.30 | FALSE |
| 11 | GTEx | Brain Cortex | AC000120.7 | 0.12 | 0.08 | enet | 16 | 0.07 | 7.0e-03 | 3.81 | -6.3 | 3.8e-10 | -0.42 | 0.14 | 0.05 | FALSE |
| 12 | GTEx | Breast Mammary Tissue (Female) | AC007566.10 | 0.04 | -0.01 | lasso | 2 | 0.01 | 2.0e-01 | 0.82 | -7.6 | 3.0e-14 | -0.37 | 0.02 | 0.24 | FALSE |
| 13 | GTEx | Cells Transformed fibroblasts | GATAD1 | 0.23 | 0.20 | lasso | 4 | 0.22 | 1.4e-16 | 9.39 | -12.2 | 1.9e-34 | -0.58 | 0.98 | 0.02 | FALSE |
| 14 | GTEx | Colon Transverse | GATAD1 | 0.13 | 0.00 | enet | 16 | 0.05 | 3.0e-03 | 9.39 | -9.9 | 3.8e-23 | -0.38 | 0.20 | 0.16 | FALSE |
| 15 | GTEx | Esophagus Mucosa | GATAD1 | 0.16 | 0.05 | enet | 16 | 0.08 | 7.3e-06 | 9.39 | -9.7 | 4.2e-22 | -0.42 | 0.79 | 0.09 | FALSE |
| 16 | GTEx | Esophagus Muscularis | GATAD1 | 0.18 | 0.10 | enet | 33 | 0.13 | 1.6e-08 | 9.39 | -8.2 | 1.9e-16 | -0.32 | 0.97 | 0.00 | FALSE |
| 17 | GTEx | Esophagus Muscularis | FAM133B | 0.07 | 0.01 | enet | 2 | 0.01 | 1.2e-01 | -10.71 | -10.7 | 1.5e-26 | -0.46 | 0.06 | 0.43 | FALSE |
| 18 | GTEx | Lung | GATAD1 | 0.15 | 0.12 | lasso | 2 | 0.11 | 1.1e-08 | 9.39 | -9.5 | 1.9e-21 | -0.42 | 0.99 | 0.00 | FALSE |
| 19 | GTEx | Muscle Skeletal | PEX1 | 0.06 | 0.03 | lasso | 5 | 0.02 | 2.7e-03 | 6.96 | 7.4 | 1.2e-13 | 0.30 | 0.52 | 0.16 | FALSE |
| 20 | GTEx | Muscle Skeletal | GATAD1 | 0.05 | 0.00 | enet | 13 | 0.01 | 2.4e-02 | 3.60 | -9.0 | 2.5e-19 | -0.38 | 0.47 | 0.03 | FALSE |
| 21 | GTEx | Nerve Tibial | GATAD1 | 0.30 | 0.19 | lasso | 5 | 0.23 | 1.8e-16 | 9.39 | -8.0 | 1.1e-15 | -0.35 | 1.00 | 0.00 | FALSE |
| 22 | GTEx | Pancreas | GATAD1 | 0.12 | 0.13 | lasso | 2 | 0.14 | 2.0e-06 | 9.39 | -8.6 | 1.0e-17 | -0.40 | 0.16 | 0.52 | FALSE |
| 23 | GTEx | Skin Not Sun Exposed Suprapubic | GATAD1 | 0.22 | 0.27 | lasso | 4 | 0.26 | 1.1e-14 | 9.39 | -9.7 | 4.3e-22 | -0.42 | 1.00 | 0.00 | FALSE |
| 24 | GTEx | Skin Sun Exposed Lower leg | PEX1 | 0.18 | 0.06 | enet | 41 | 0.03 | 1.5e-03 | -8.73 | -8.5 | 1.5e-17 | -0.39 | 0.20 | 0.16 | FALSE |
| 25 | GTEx | Skin Sun Exposed Lower leg | GATAD1 | 0.30 | 0.10 | enet | 14 | 0.16 | 7.0e-13 | 9.39 | -9.5 | 2.7e-21 | -0.39 | 1.00 | 0.00 | FALSE |
| 26 | GTEx | Spleen | PEX1 | 0.18 | 0.00 | enet | 38 | 0.05 | 2.4e-02 | 4.47 | -7.3 | 2.6e-13 | -0.32 | 0.08 | 0.08 | FALSE |
| 27 | GTEx | Stomach | GATAD1 | 0.30 | 0.13 | lasso | 5 | 0.15 | 8.6e-08 | 9.39 | -9.7 | 2.5e-22 | -0.46 | 0.98 | 0.00 | FALSE |
| 28 | GTEx | Testis | CDK6 | 0.10 | 0.10 | lasso | 3 | 0.09 | 8.0e-05 | 16.71 | -17.4 | 6.0e-68 | -0.92 | 0.01 | 0.98 | TRUE |
| 29 | GTEx | Thyroid | GATAD1 | 0.18 | 0.06 | lasso | 4 | 0.06 | 3.3e-05 | 9.39 | -9.0 | 2.3e-19 | -0.43 | 0.94 | 0.03 | FALSE |
| 30 | METSIM | Adipose | GATAD1 | 0.10 | 0.05 | lasso | 7 | 0.06 | 9.4e-10 | 3.60 | -7.8 | 7.8e-15 | -0.40 | 1.00 | 0.00 | FALSE |
| 31 | ROSMAP | Brain Pre-frontal Cortex | KRIT1 | 0.04 | 0.03 | bslmm | 311 | 0.01 | 9.0e-03 | 4.45 | 8.5 | 1.5e-17 | 0.49 | 0.74 | 0.05 | FALSE |
| 32 | ROSMAP | Brain Pre-frontal Cortex | GATAD1 | 0.17 | 0.15 | lasso | 4 | 0.16 | 6.0e-20 | 9.27 | -9.7 | 4.0e-22 | -0.43 | 1.00 | 0.00 | FALSE |
| 33 | YFS | Blood | CYP51A1 | 0.03 | 0.06 | blup | 288 | 0.05 | 1.2e-16 | 3.88 | -5.8 | 5.3e-09 | -0.31 | 1.00 | 0.00 | FALSE |
| 34 | YFS | Blood | GATAD1 | 0.01 | 0.01 | blup | 297 | 0.01 | 5.1e-04 | 9.39 | -10.5 | 6.5e-26 | -0.55 | 0.75 | 0.08 | FALSE |
| 35 | The Cancer Genome Atlas | Breast Invasive Carcinoma | GATAD1 | 0.06 | 0.04 | lasso | 6 | 0.04 | 2.2e-09 | 9.22 | -8.8 | 1.0e-18 | -0.31 | 0.01 | 0.99 | FALSE |
| 36 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GATAD1 | 0.04 | 0.04 | lasso | 2 | 0.03 | 2.8e-04 | 9.22 | -8.9 | 5.8e-19 | -0.36 | 0.00 | 0.97 | FALSE |
| 37 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | C7orf64 | 0.06 | 0.02 | blup | 36 | 0.02 | 6.0e-02 | 6.99 | 6.2 | 7.8e-10 | 0.22 | 0.02 | 0.52 | FALSE |