Best TWAS P=7.33e-11 · Best GWAS P=1.71e-13 conditioned to 0.0012
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ERI1 | 0.06 | 0.04 | lasso | 3 | 0.04 | 9.0e-06 | -5.3 | -5.7 | 9.7e-09 | 0.59 | 0.97 | 0.02 | FALSE |
| 2 | GTEx | Artery Aorta | ERI1 | 0.11 | 0.08 | lasso | 5 | 0.10 | 5.1e-06 | 6.1 | -5.5 | 3.1e-08 | 0.50 | 0.86 | 0.08 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | ERI1 | 0.34 | 0.35 | lasso | 7 | 0.35 | 1.9e-27 | 6.1 | -6.5 | 7.3e-11 | 0.49 | 0.85 | 0.15 | TRUE |
| 4 | NTR | Blood | PPP1R3B | 0.03 | 0.02 | enet | 11 | 0.02 | 1.5e-07 | 6.2 | 6.4 | 1.3e-10 | -0.49 | 0.75 | 0.25 | TRUE |
| 5 | The Cancer Genome Atlas | Bladder Urothelial Carcinoma | ERI1 | 0.05 | 0.01 | blup | 72 | 0.01 | 5.0e-02 | 6.1 | -5.6 | 1.7e-08 | 0.46 | 0.00 | 0.86 | FALSE |
| 6 | The Cancer Genome Atlas | Lung Adenocarcinoma | ERI1 | 0.06 | 0.04 | blup | 72 | 0.04 | 1.5e-05 | 4.2 | -6.2 | 6.4e-10 | 0.56 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SGK223 | 0.06 | 0.05 | lasso | 3 | 0.04 | 4.4e-05 | -5.3 | 5.3 | 1.1e-07 | -0.25 | 0.00 | 0.98 | TRUE |
| 8 | The Cancer Genome Atlas | Thyroid Carcinoma | PPP1R3B | 0.06 | 0.02 | enet | 7 | 0.03 | 8.0e-04 | -4.3 | -5.4 | 6.8e-08 | 0.47 | 0.16 | 0.10 | FALSE |