Hub : Genes

SGK223

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.1170	0.0370	1.8e-05	0.003	0.034	0.033	0.035	0.019	1.3e-01	4.5e-05	5.4e-05	3.6e-05	2.0e-03
2	GTEx	Esophagus Muscularis	0.1130	0.0450	2.3e-03	0.063	NA	0.023	NA	0.043	1.2e-04	NA	1.4e-02	NA	1.2e-03
3	GTEx	Nerve Tibial	0.1693	0.0511	1.1e-05	0.019	NA	0.039	NA	0.040	1.7e-02	NA	8.9e-04	NA	8.1e-04
4	GTEx	Testis	0.2910	0.0830	3.4e-05	0.020	NA	0.074	NA	0.015	4.1e-02	NA	3.5e-04	NA	6.6e-02
5	GTEx	Thyroid	0.1920	0.0450	0.0e+00	0.352	NA	0.360	NA	0.353	5.7e-28	NA	1.1e-28	NA	4.6e-28
6	METSIM	Adipose	0.0475	0.0207	4.2e-03	0.011	0.013	0.007	0.013	0.012	7.9e-03	4.5e-03	2.3e-02	3.4e-03	4.8e-03
7	ROSMAP	Brain Pre-frontal Cortex	0.0735	0.0269	1.0e-06	0.023	0.050	0.029	0.048	0.024	4.7e-04	4.3e-07	9.7e-05	7.6e-07	3.5e-04
8	TCGA	Lung Squamous Cell Carcinoma	0.0657	0.0290	6.4e-04	0.024	0.035	0.013	NA	0.024	8.9e-04	6.3e-05	1.0e-02	NA	8.4e-04
9	TCGA	Prostate Adenocarcinoma	0.0578	0.0286	7.1e-03	0.046	0.013	0.029	NA	0.040	1.3e-05	1.6e-02	4.6e-04	NA	4.4e-05
10	TCGA	Thyroid Carcinoma	0.1620	0.0500	0.0e+00	0.199	0.210	0.218	NA	0.217	4.2e-19	4.1e-20	6.1e-21	NA	7.8e-21

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	1.6	2.6	7.5	-1.6	-0.2	0.1	-2.2	-2.0	0.3	1.0	0.6	2.7	-2.4
Bipolar Disorder or Schizophrenia	3.7	9.0	19.4	-0.0	-2.4	-1.1	-4.4	-4.2	-0.8	3.1	-1.6	3.8	-4.4
Depressed Affect (Nagel 2018)	1.6	3.3	12.2	-0.7	0.1	-1.0	3.5	2.4	0.4	-2.3	0.7	-1.7	2.1
Depression (Nagel 2018)	1.1	1.7	6.0	0.2	0.4	-0.1	2.4	0.9	1.2	-1.9	0.8	-1.0	1.8
Intelligence (Savage-Jansen 2018)	0.4	1.2	5.7	-0.2	1.5	2.4	0.5	1.0	0.7	-0.1	0.9	0.5	1.0
Neuroticism (Nagel 2018)	1.5	3.5	11.8	0.7	0.0	-1.4	3.4	2.4	0.3	-2.2	1.2	-1.9	2.2
Schizophrenia (2018)	3.8	8.0	14.6	1.2	-2.9	-1.4	-3.8	-3.7	-1.3	3.1	-2.6	2.6	-3.7
Schizophrenia vs Biploar Disorder	1.2	1.6	3.4	0.1	-1.3	-1.3	-1.9	-1.5	-0.8	0.4	-1.8	-0.0	-1.7
Worry (Nagel 2018)	0.7	1.4	5.0	2.2	0.1	-1.4	2.0	1.2	0.3	-0.7	0.2	-0.5	0.8
Alzheimer’s Disease (in mother)	0.9	1.1	2.7	1.1	-0.8	-1.6	1.1	-0.6	-0.0	1.2	-0.7	-1.6	-0.2
Alzheimer’s Disease (in father)	0.3	0.3	1.0	1.0	-0.4	0.3	0.8	-0.0	-0.9	0.0	0.3	-0.4	0.4
Alzheimer’s Disease (including proxy)	0.8	1.2	2.9	1.7	-0.7	-1.2	1.6	-0.3	-0.7	1.0	-0.7	-1.7	0.3
Crohns Disease (2017)	0.4	0.9	2.5	-0.4	-0.3	0.2	-1.6	-1.3	-0.3	0.4	-1.5	-1.0	-1.2
Irritable Bowel Disease (IBD)	0.3	0.8	3.4	-0.9	-0.6	-0.2	-0.5	-0.4	-0.8	-0.4	-1.6	-1.9	-0.1
Ulcerative Colitis (UC)	0.3	0.6	2.5	-0.8	-0.5	-0.3	0.4	0.5	-0.5	-0.8	-0.8	-1.6	0.6
Major Depression (MDD)	0.5	0.6	3.2	1.8	-0.4	0.0	0.7	0.5	-0.7	-0.4	-0.7	-0.8	0.6
Reaction Time	0.5	1.0	2.4	-1.6	0.6	0.0	1.3	1.0	-1.5	-1.2	-0.4	-0.4	0.6
Verbal and Numeric Reasoning (VNR)	1.3	3.0	8.0	-0.2	2.3	2.8	1.2	1.6	2.2	-0.7	2.0	-1.0	1.7
Breast Cancer	1.2	2.9	7.1	-1.0	-1.5	-1.7	-1.9	-2.7	0.2	1.5	0.8	2.5	-1.7
Ovarian Cancer	0.6	0.8	3.8	-0.9	-1.9	-1.3	-0.4	-0.6	0.2	0.2	1.0	0.4	-0.3
Prostate Cancer	1.1	1.6	3.3	1.8	-1.4	-1.5	-1.4	-1.6	1.0	1.2	-0.3	0.2	-1.1
Age at First Birth	1.0	1.5	5.9	-1.1	1.6	1.3	-0.5	1.4	0.1	-2.4	0.8	0.1	1.0
Bipolar Disorder (2011)	1.8	1.7	5.7	-1.9	0.5	0.5	-1.6	-1.1	0.7	-0.1	1.4	2.4	-1.1
Body Mass Index (BMI) (2010)	2.3	3.1	7.4	-0.6	-1.9	-2.6	-2.1	-2.7	-0.6	0.9	-0.0	0.9	-2.7
Coronary Artery Disease (CAD)	0.4	0.4	2.1	0.2	0.1	0.1	-0.8	0.4	-1.4	0.1	-1.0	0.5	0.6
Crohns Disease (2012)	0.7	1.1	3.7	-1.6	-0.1	0.0	-1.9	-1.3	-0.5	0.1	-0.8	-0.5	-1.3
Mean Putamen Volume	1.9	2.2	7.0	1.1	-1.5	-1.5	-0.3	-0.7	-2.6	1.3	-2.6	0.2	-0.5
Fasting Glucose	1.1	1.3	4.7	0.7	-0.2	-0.6	-0.9	-1.6	0.2	1.3	0.5	2.2	-1.3
HbA1C	0.7	0.8	2.3	-1.5	-0.4	-0.6	-1.3	-0.7	-1.0	0.7	0.1	0.4	-1.0
HDL Cholesterol	0.6	1.0	2.2	1.5	-0.8	-1.0	0.9	1.1	0.2	-1.2	0.6	-0.7	1.3
LDL Cholesterol	0.4	0.6	1.5	-0.9	-1.2	-0.5	-1.0	-1.0	0.2	0.1	1.2	0.1	-0.6
Lupus	7.2	11.0	19.5	1.1	-4.3	-3.6	-3.9	-4.4	-2.2	3.6	-2.3	1.3	-4.1
Neuroticism (2016)	13.8	19.8	55.7	0.4	3.3	2.4	6.1	7.5	1.9	-6.0	2.5	-2.1	6.2
Primary Biliary Cirrhosis	1.6	2.3	6.2	2.5	-2.3	-1.6	-1.3	-1.8	-0.6	1.5	-0.6	-0.1	-1.2
Rheumatoid Arthritis	0.5	0.7	3.6	-0.3	-1.5	-1.9	0.1	-0.3	-0.9	0.2	-0.4	-0.5	-0.4
Schizophrenia (2014)	4.2	9.3	21.8	-0.2	-2.2	-1.1	-4.6	-4.5	-1.1	3.3	-2.6	2.5	-4.7
Triglycerides	2.8	4.6	15.3	2.1	0.3	1.6	2.8	3.1	-0.1	-1.6	-0.0	-1.9	3.9
Type 2 Diabetes (T2D) (2012)	2.8	3.2	6.3	0.7	-2.0	-2.4	-2.5	-2.1	0.9	1.6	-0.1	1.3	-2.3
Ulcerative Colitis	1.1	1.6	4.7	-0.5	0.4	-0.0	1.4	1.5	-0.7	-1.5	-0.8	-1.9	2.2
Blood Eosinophil Count	0.1	0.9	2.7	-0.9	1.4	0.7	0.0	1.2	-1.2	-0.0	-0.2	1.6	-0.4
Blood Platelet Count	0.1	0.9	5.0	-0.9	0.9	1.0	1.1	-0.5	0.5	0.3	-0.3	-2.2	-0.1
Blood Red Count	0.2	2.0	5.4	1.8	-0.8	0.0	1.5	0.0	-1.4	1.8	-1.9	-0.6	2.3
Blood White Count	0.1	0.7	2.7	-1.0	0.8	-0.0	1.1	0.8	-0.5	-0.0	-0.4	-1.6	-0.8
Heel T-Score	0.6	5.0	29.4	2.5	0.3	0.4	-0.7	-0.6	-3.1	1.6	-5.4	-0.1	-1.1
BMI	0.2	1.3	4.0	-0.5	-2.0	-2.0	-0.0	0.6	-1.7	-0.9	0.2	0.5	0.3
Height	0.2	3.9	16.7	-0.7	2.1	2.8	-2.4	0.8	0.3	-1.6	0.3	4.1	0.7
Waist Hip Ratio (WHR)	0.4	1.6	5.2	-0.3	1.4	1.7	-0.3	0.4	2.3	0.5	2.0	1.1	-0.9
Systolic Blood Pressure	0.2	0.9	3.5	1.9	0.3	0.5	0.1	1.2	-1.0	0.3	-0.8	-1.1	0.9
Smoking Status	0.8	1.8	5.7	1.1	-1.1	-0.7	0.8	0.8	-2.4	-1.3	-1.6	-1.3	1.5
Allergy or Eczema	0.6	1.5	4.6	-1.8	1.0	-0.1	-0.1	0.3	-2.1	-0.4	-1.5	0.8	-1.6
Cardiovascular Disease	0.4	1.4	4.0	1.4	-0.2	-0.6	0.5	1.1	-2.0	-0.1	-1.4	-1.4	1.7
Hypothyroidism (self reported)	1.6	3.7	22.5	1.6	1.3	1.2	1.0	4.7	-1.6	-0.4	-0.9	0.3	2.1
Respiratory disease	1.0	2.3	6.4	1.1	0.5	0.1	-1.3	-2.2	-0.2	2.3	-1.9	0.4	-2.5
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.1	0.0	-1.1	-1.6	-0.6	0.1	0.0	-1.2	1.8	1.5	0.0
Lung FEV1/FVC ratio	0.3	1.7	7.9	2.8	-1.2	-0.1	-0.6	0.7	0.8	-0.4	1.7	-0.3	1.7
Lung FVC	0.2	0.9	4.1	0.0	-0.7	-1.5	0.5	-0.9	-0.3	-0.3	-0.8	-2.0	0.3
Neuroticism	0.4	1.0	5.6	0.4	0.1	-1.0	2.4	0.3	0.5	-0.4	0.4	-1.3	0.8
Chronotype (morning person)	2.0	4.7	16.5	-0.3	0.2	0.8	-2.0	-1.3	4.1	0.6	3.0	3.1	-2.3
Hair Pigment	0.1	1.5	7.3	-0.5	1.5	0.4	-0.0	-0.2	2.7	-1.8	1.0	-0.5	-0.2
Tanning	0.1	1.0	4.0	-1.0	0.2	1.0	-1.2	-0.9	-0.5	1.1	-2.0	-0.5	-0.3
Hand grip strength (left)	1.1	2.8	10.1	3.2	-2.3	-1.8	-1.0	-1.5	-1.0	1.7	-1.4	-0.7	0.2
Number of treatments/medications taken	0.6	1.1	3.1	0.0	-1.0	-1.1	-1.8	-0.8	0.5	0.3	1.5	0.6	-1.4
Average weekly spirits intake	0.6	0.7	2.8	1.0	0.4	0.4	0.6	1.7	0.6	-0.7	0.5	-0.4	1.2
Sensitivity / hurt feelings	6.9	11.8	30.1	1.6	1.2	0.9	4.3	5.4	0.4	-4.5	1.9	-3.3	5.5
Frequency of depressed mood in last 2 weeks	4.9	6.9	22.3	0.3	2.2	1.2	4.7	3.3	1.0	-3.1	1.5	-1.4	3.8
Hearing difficulty/problems: Yes	0.6	0.9	3.2	0.1	0.5	-0.4	1.5	0.9	-0.5	-1.1	-0.9	-1.8	0.5
Relative age of first facial hair	0.3	0.5	1.8	1.3	-0.8	-0.5	0.9	0.3	0.4	-0.6	-0.3	-1.1	0.3
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	3.8	-1.1	-0.4	-0.3	-0.0	0.7	0.1	-1.5	1.9	-0.2	1.0
Ever used hormone-replacement therapy (HRT)	1.3	1.7	6.0	1.4	1.2	1.0	-0.9	-1.2	-0.2	2.5	-1.3	0.5	-1.5
Ever had hysterectomy (womb removed)	1.9	2.2	5.9	-0.9	-0.2	-0.2	-2.1	-2.4	0.8	2.4	0.2	0.6	-2.0
Systolic blood pressure, automated reading	5.7	16.6	34.7	0.6	-3.3	-3.4	-5.2	-5.9	-2.4	5.6	-2.9	1.7	-5.7
Eye problems/disorders: Diabetes related eye disease	0.6	0.6	2.3	-0.1	0.1	0.8	0.0	0.1	1.5	-0.1	0.9	-0.8	1.5
Angina	0.3	0.4	1.3	-1.0	-0.8	-0.8	-0.4	-0.3	-0.7	0.3	0.0	-1.2	-0.2
Medication for hormone replacement therapy	0.9	1.0	2.3	0.4	0.7	0.7	-1.0	-1.5	-0.6	1.5	-0.8	0.8	-1.4
Vitamin and mineral supplements	1.8	2.4	5.7	1.2	-1.2	-0.4	2.2	2.3	-0.5	-1.5	-0.1	-1.7	2.4
Supplements: Zinc	2.4	2.6	7.0	-0.8	0.5	0.8	-2.2	-2.4	-0.3	1.1	-0.1	2.6	-2.3
Medication: Co-codamol	1.6	1.8	3.7	1.6	-1.9	-1.9	-0.9	-1.1	-0.9	1.4	-1.6	0.5	-0.9
Medication: Metformin	1.4	2.0	4.2	0.7	-1.5	-1.4	-2.0	-1.9	-0.1	1.7	0.4	1.2	-1.6
Diabetes (father)	2.5	3.2	6.8	-0.7	-2.2	-1.9	-2.3	-2.6	0.7	2.1	0.0	-0.1	-2.4
Diabetes (mother)	0.4	0.5	1.2	-1.0	-0.4	-0.8	-0.4	-1.1	0.8	0.1	0.3	-0.5	-0.8
Severe depression (siblings)	0.3	0.3	1.1	-0.5	-0.4	-0.5	0.9	-1.0	-0.5	0.4	0.0	0.1	-0.3
Pack years adult smoking proportion	1.7	2.7	5.5	0.9	-1.9	-1.4	-2.4	-2.2	-0.6	2.0	-0.0	1.3	-2.0
Impedance of leg (right)	6.0	28.9	84.5	3.0	3.9	3.1	6.2	9.2	-0.2	-6.4	1.1	-4.2	8.5
Leg fat-free mass (left)	2.6	14.0	34.3	-1.1	-3.0	-2.2	-5.1	-5.9	-0.7	4.2	-0.6	4.4	-5.2
Trunk fat percentage	1.1	4.4	10.9	0.7	-2.3	-1.9	-2.5	-2.5	-1.3	3.3	-0.9	1.9	-2.3
Hand grip strength (right)	0.8	2.2	7.4	2.7	-1.8	-1.2	-0.6	-1.2	-0.5	1.3	-1.1	-2.1	0.6
Townsend deprivation index at recruitment	0.7	1.0	2.8	1.1	1.3	1.7	0.5	0.5	0.1	0.1	0.3	1.7	0.7
Current tobacco smoking	4.3	7.0	13.8	0.6	-3.0	-2.3	-2.4	-3.7	-2.6	3.1	-2.6	0.7	-3.5
Average weekly fortified wine intake	1.5	1.7	4.3	-0.1	1.4	2.1	-0.2	1.8	-1.3	-1.0	-0.1	0.6	2.1
Maternal smoking around birth	0.5	0.7	1.6	1.1	0.9	0.3	0.6	1.1	-0.4	-1.2	0.2	1.0	1.0
Fed-up feelings	9.5	17.3	42.1	0.8	2.4	0.8	6.5	6.4	0.3	-5.5	1.6	-3.1	6.4
Frequency of unenthusiasm / disinterest in last 2 weeks	2.6	3.4	10.7	1.8	1.6	0.5	3.3	2.1	1.0	-2.1	0.2	-0.5	2.7
Relative age voice broke	0.4	0.6	3.3	1.8	0.0	0.8	0.1	0.3	1.2	-0.4	-0.4	0.2	0.3
Taking other prescription medications	0.6	0.9	3.0	0.7	-1.7	-1.4	-0.8	-0.0	-0.3	0.8	0.7	1.1	0.2
Age when periods started (menarche)	1.0	2.4	8.6	-1.1	1.2	0.6	1.7	2.9	0.4	-2.9	-0.0	-0.6	0.6
Bilateral oophorectomy (both ovaries removed)	0.7	0.8	2.1	0.5	0.4	0.5	-1.2	-1.4	0.5	1.3	0.4	0.5	-1.1
Heel bone mineral density (BMD) T-score, automated (left)	14.8	33.7	86.8	-0.4	-4.7	-4.7	-6.8	-9.3	-1.7	6.8	-4.2	3.6	-8.9
Tinnitus: Yes, but not now, but have in the past	2.0	2.2	4.3	-0.6	-2.0	-2.1	-1.6	-1.7	-1.7	0.4	-1.4	-1.1	-1.3
Qualifications: CSEs or equivalent	1.1	1.4	9.7	3.1	-1.0	-0.5	0.5	-0.1	-0.2	0.7	-1.3	-0.3	0.8
Serious illness, injury or assault to yourself	1.9	2.3	3.7	-0.6	1.1	0.9	1.6	1.7	1.2	-1.9	1.7	-1.8	1.9
High blood pressure	5.2	14.6	35.5	0.1	-3.0	-3.0	-5.3	-6.0	-1.5	4.9	-1.4	2.5	-5.5
Hayfever, allergic rhinitis or eczema	0.5	1.1	3.5	-0.9	0.3	-0.4	-0.6	-0.5	-1.9	-0.1	-1.0	1.3	-1.6
Multivitamins +/- minerals	0.6	0.8	2.3	-1.0	1.0	0.0	-0.8	-1.5	-0.4	0.8	-0.4	0.5	-1.4
Stomach or abdominal pain in last month	1.9	2.4	10.8	3.3	-0.2	-0.4	1.0	2.1	0.2	-0.6	-0.4	-1.6	2.2
Supplements: Glucosamine	0.5	0.7	1.9	0.3	0.2	0.7	-0.5	-0.4	1.3	1.2	1.4	0.7	0.4
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	7.9	-2.8	1.3	0.4	-0.4	-0.0	-0.2	-1.8	0.5	-1.5	0.1
Medication: Atenolol	2.1	2.6	7.2	-0.4	-1.1	-0.8	-2.0	-2.7	-1.4	2.1	-1.6	1.0	-1.9
Medication: Levothyroxine sodium	6.5	10.9	39.7	0.7	2.6	2.6	2.5	6.3	-1.4	-4.1	0.9	-1.5	5.3
Sitting height	1.0	6.9	28.3	-0.7	0.9	1.7	-4.1	-3.0	0.4	1.8	0.4	5.3	-2.7
Chronic bronchitis/emphysema (father)	0.4	0.4	2.0	-1.4	1.0	0.6	0.6	0.2	0.6	-0.1	0.3	0.1	0.0
High blood pressure (mother)	1.9	2.7	8.5	-1.6	0.3	0.2	-1.5	-2.3	-1.1	2.4	-1.1	0.4	-2.9
Body mass index (BMI)	6.5	27.7	63.4	-0.4	-5.3	-4.8	-6.2	-8.0	-2.2	6.8	-2.5	3.6	-7.4
Impedance of leg (left)	6.4	30.9	91.8	2.9	3.9	3.1	6.4	9.6	0.2	-7.1	1.4	-4.2	8.5
Leg predicted mass (left)	2.6	14.0	33.8	-1.0	-3.0	-2.1	-5.1	-5.8	-0.6	4.2	-0.5	4.5	-5.2
Trunk fat mass	1.7	7.3	14.3	0.6	-2.7	-2.1	-3.6	-3.5	-0.9	3.8	-0.6	3.0	-3.2
Waist circumference	1.1	4.1	10.4	-0.4	-1.9	-1.4	-3.1	-2.2	-0.5	1.8	0.6	3.2	-2.5
Number of incorrect matches in round	0.1	0.2	0.8	0.5	-0.3	0.1	-0.2	0.2	-0.0	-0.9	0.1	0.4	0.6
Past tobacco smoking	1.6	2.9	4.9	-1.9	2.1	1.6	2.0	2.2	1.3	-2.1	1.7	0.2	0.8
Alcohol usually taken with meals	2.1	3.4	8.2	-1.5	0.3	1.0	-2.9	-2.2	1.0	1.7	0.8	2.4	-2.7
Nervous feelings	11.0	20.5	54.2	2.5	4.0	2.8	6.0	7.4	1.0	-5.2	1.6	-2.6	6.8
Frequency of tenseness / restlessness in last 2 weeks	2.2	3.5	8.8	0.0	2.4	0.9	3.0	2.0	1.7	-2.6	1.3	-0.6	2.0
Hearing difficulty/problems with background noise	1.1	1.7	4.7	-0.6	0.8	0.3	2.2	1.2	0.4	-1.4	1.4	-1.9	1.4
Hair/balding pattern: Pattern 2	0.8	1.0	3.8	0.6	-1.0	-0.3	-0.1	-1.4	-0.2	1.9	-1.4	-0.9	-0.6
Had menopause	1.6	2.0	6.0	-0.4	-0.0	-0.2	-2.4	-1.4	0.4	1.4	0.4	2.4	-2.0
Had other major operations	2.1	2.5	10.9	-0.9	-0.1	-0.9	-2.0	-2.3	-0.4	1.0	-0.6	1.3	-3.3
Forced vital capacity (FVC)	1.4	5.2	14.5	0.2	1.5	1.4	3.3	3.1	-0.4	-2.7	-0.3	-2.3	3.8
Heel bone mineral density (BMD) T-score, automated (right)	16.2	37.2	87.2	-0.7	-5.7	-5.9	-7.8	-9.3	-2.7	6.5	-3.4	3.6	-9.1
Ever unenthusiastic/disinterested for a whole week	0.6	0.7	1.8	-1.3	0.8	-0.2	1.0	0.3	0.3	-1.1	1.1	0.8	0.7
Qualifications: None of the above	0.5	1.0	3.0	1.3	-0.8	-0.4	0.8	0.1	-1.7	1.2	-1.4	0.4	0.5
Financial difficulties in last 2 years	0.9	1.2	4.8	2.2	-0.9	-1.2	-0.7	-0.8	0.3	1.1	-1.4	0.3	-0.7
Mouth/teeth dental problems	4.1	6.2	14.3	-1.1	2.9	3.1	2.2	3.8	0.3	-2.5	1.1	-1.6	3.7
Heart attack	1.0	1.3	3.7	-0.0	-1.7	-1.7	-0.5	0.5	-1.9	-1.0	0.9	-0.5	1.0
Allergy	1.8	4.1	12.4	0.7	0.7	1.4	2.2	2.4	2.5	-1.6	1.6	-1.9	3.5
Pain all over the body in last month	1.7	1.9	5.5	0.3	-1.6	-1.2	-2.3	-2.0	0.8	0.4	0.3	1.7	-1.0
Diabetes (self-reported)	0.6	1.0	2.7	0.1	-1.5	-1.6	-0.8	-1.3	-0.5	0.8	0.6	0.9	-0.7
Hayfever/allergic rhinitis (self-reported)	1.1	1.5	4.4	-0.9	1.8	1.4	1.3	2.1	-0.5	-1.0	0.7	0.0	1.1
Medication: Ramipril	1.7	2.2	4.6	1.2	-2.1	-1.4	-1.7	-2.0	-0.7	1.6	-1.2	0.5	-1.4
Medication: Simvastatin	1.6	2.3	6.9	-0.6	-1.7	-2.4	-2.6	-1.2	-0.3	-0.0	1.2	1.1	-1.8
Fluid intelligence score	1.2	2.5	6.5	0.1	2.1	2.5	0.6	1.4	2.1	-0.6	1.6	-1.5	1.4
Illnesses of siblings	1.2	1.6	3.5	-1.8	1.4	1.8	0.8	0.6	0.6	-1.5	1.9	0.2	1.0
Neuroticism score	16.1	33.6	79.2	1.9	4.1	2.9	8.3	8.9	1.6	-7.0	2.8	-4.5	8.9
Weight	2.5	12.5	25.3	-0.4	-3.3	-2.7	-4.8	-5.0	-1.4	4.1	-1.1	4.0	-4.7
Impedance of arm (right)	6.9	32.1	79.5	1.2	5.7	5.0	6.9	8.9	1.0	-6.5	2.1	-4.0	8.5
Arm fat percentage (right)	3.2	12.6	25.4	0.7	-4.0	-3.6	-4.0	-5.0	-2.2	5.0	-1.7	2.3	-4.2
Trunk fat-free mass	1.2	6.6	17.0	-0.6	-2.2	-1.4	-4.1	-3.7	-0.2	2.1	0.2	3.8	-3.0
Hip circumference	2.6	11.1	23.3	-0.5	-3.3	-2.6	-4.8	-4.7	-1.6	3.3	-0.8	3.8	-4.2
Time employed in main current job	2.9	3.3	7.8	0.1	1.7	1.3	-0.1	2.8	2.3	-2.3	2.6	-0.5	1.8
Alcohol intake versus 10 years previously	1.0	1.5	5.1	1.2	-2.3	-1.3	0.7	0.7	-0.4	-1.2	0.7	-0.4	1.8
Father’s age at death	6.6	8.9	15.3	-0.8	3.6	3.6	3.0	3.7	2.6	-2.5	2.5	-2.2	3.9
Worrier / anxious feelings	15.2	28.7	74.3	3.6	4.1	3.4	7.1	8.6	1.2	-5.6	2.3	-3.0	8.6
Frequency of tiredness / lethargy in last 2 weeks	1.7	2.8	8.1	2.0	0.2	0.5	2.8	2.4	-0.7	-1.5	-0.3	-0.6	2.6
Falls in the last year	0.3	0.4	1.3	0.3	-1.2	-1.1	0.6	-0.3	-0.7	0.1	-0.2	-0.1	-0.4
Hair/balding pattern: Pattern 3	1.6	2.4	10.5	-1.4	-0.4	-0.3	-0.3	0.8	2.5	-2.1	3.2	0.1	0.2
Number of live births	0.3	0.5	3.1	-0.2	1.7	0.6	0.4	0.4	-0.0	0.0	-0.9	0.2	-0.5
Forced expiratory volume in 1-second (FEV1)	3.0	10.2	28.2	1.1	1.6	1.5	4.5	4.8	-0.0	-4.0	0.3	-2.9	5.3
Pulse rate	1.0	1.7	5.2	-0.3	1.1	1.3	0.4	2.2	-0.3	-2.3	0.6	0.5	1.7
Happiness	0.5	0.7	2.1	0.8	-0.9	-1.0	-0.5	-0.0	-1.2	-0.2	0.3	1.5	0.4
Noisy workplace	2.3	2.8	8.6	1.0	-2.9	-2.8	1.3	1.1	-2.4	-0.4	-0.6	-0.6	1.0
Qualifications: A levels/AS levels or equivalent	3.8	8.3	25.6	-2.1	5.1	4.7	1.0	2.7	2.5	-2.8	2.2	-0.2	1.8
Serious illness, injury or assault of a close relative in last 2 years	3.3	3.8	7.3	-1.1	1.7	2.2	2.7	2.5	1.9	-2.0	1.7	-0.4	2.3
Mouth/teeth dental problems: Dentures	6.4	10.7	17.5	1.1	-3.2	-2.9	-3.9	-4.2	-2.9	3.9	-2.6	2.9	-4.0
Asthma	1.9	3.8	12.6	-0.1	0.3	-0.0	-2.3	-3.1	-0.4	2.6	-1.0	1.5	-3.6
Medication: Ibuprofen (e.g. Nurofen)	1.2	1.5	6.4	0.6	0.6	0.8	1.8	1.3	0.1	-0.4	-0.5	-2.5	1.4
Medication: Cholesterol lowering	0.9	1.4	2.9	-1.0	-1.4	-1.4	-1.7	-1.2	0.1	0.1	1.3	0.5	-1.5
Depression (self-reported)	1.6	1.9	8.9	-0.5	0.8	0.2	3.0	1.7	-0.5	-1.5	0.3	-0.9	1.7
Medication: Lansoprazole	0.9	1.0	2.1	1.1	-1.3	-0.5	-1.1	-1.0	-0.8	1.4	-0.2	1.3	-0.8
Prospective memory result	0.8	1.0	3.9	1.5	-0.8	-1.1	-0.4	-0.2	-0.8	0.6	-2.0	0.5	-0.3
Lung cancer (father)	0.3	0.3	0.8	0.9	0.3	0.9	0.7	0.3	-0.1	0.6	-0.7	0.6	-0.2
Illnesses of mother	0.9	1.1	2.5	-0.7	0.9	1.2	-1.0	-0.0	1.4	-1.3	1.6	1.2	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	2.9	9.4	23.7	1.0	1.2	1.1	4.3	4.5	0.5	-4.1	1.2	-3.0	4.9
Pulse wave Arterial Stiffness index	0.9	1.0	2.4	1.0	-1.6	-0.9	-1.2	-0.9	-0.0	1.5	-1.1	0.3	-0.7
Impedance of arm (left)	6.0	27.9	67.2	1.1	5.7	5.4	6.1	8.2	1.6	-5.9	2.3	-3.4	7.7
Arm fat mass (right)	3.9	15.9	34.8	0.3	-4.1	-3.3	-4.9	-5.9	-1.9	5.5	-1.8	3.2	-5.1
Trunk predicted mass	1.2	6.7	17.4	-0.6	-2.2	-1.4	-4.2	-3.6	-0.1	2.1	0.3	3.9	-3.0
Standing height	1.3	13.2	30.1	0.0	4.0	4.4	2.3	5.5	1.6	-4.8	2.5	1.6	5.1
Length of working week for main job	1.9	2.1	6.0	1.1	-2.5	-2.1	-1.0	-2.2	-0.0	1.1	-1.0	-0.6	-1.1
Exposure to tobacco smoke at home	0.8	0.9	1.9	-0.9	-0.6	-1.0	-1.4	-0.7	-1.2	-0.3	-1.4	-0.6	-0.7
Breastfed as a baby	0.8	1.0	2.5	-0.2	1.4	1.0	0.4	1.6	1.2	-1.4	0.1	0.4	1.0
Tense / ‘highly strung’	9.1	15.0	38.7	2.1	2.2	1.2	6.2	5.9	0.4	-4.3	1.6	-2.9	6.1
Seen doctor (GP) for nerves, anxiety, tension or depression	1.0	1.6	6.5	0.6	0.6	0.2	2.5	1.9	-0.1	-1.5	0.2	-0.1	1.5
Hair/balding pattern: Pattern 4	0.4	0.9	2.4	-1.6	1.4	1.0	-0.6	0.2	0.1	-0.9	0.1	1.4	-0.6
Birth weight of first child	1.0	1.8	9.4	3.1	0.1	0.5	1.4	1.5	0.6	1.3	-0.4	-0.2	1.2
Peak expiratory flow (PEF)	4.7	10.8	28.6	1.1	1.3	1.3	4.4	5.3	0.8	-4.5	1.2	-2.5	5.1
Pulse wave reflection index	2.5	3.1	8.0	1.0	-1.9	-1.5	-1.4	-2.5	-1.3	2.8	-2.2	-0.9	-1.0
Ever highly irritable/argumentative for 2 days	1.4	1.7	3.3	-0.9	1.8	1.6	1.7	1.3	0.4	-0.4	1.5	-0.7	1.8
Loud music exposure frequency	0.9	1.0	2.5	1.3	0.9	1.1	-0.7	-1.1	0.8	1.6	0.6	0.9	0.5
Qualifications: O levels/GCSEs or equivalent	4.5	7.1	16.0	-2.5	3.1	3.2	1.5	3.0	2.3	-4.0	2.2	-1.5	2.3
Mouth/teeth dental problems: Bleeding gums	3.4	4.4	10.9	0.0	-2.7	-3.0	-0.8	-3.2	0.9	1.9	-0.8	-0.7	-3.3
Blood clot in the leg (DVT)	1.7	2.3	6.3	-1.1	-1.7	-0.8	-2.5	-1.8	-1.4	1.8	-0.1	0.4	-1.7
Medication: Paracetamol	2.4	3.9	11.2	0.2	-0.9	-1.8	2.6	2.3	-1.6	-2.6	0.2	-3.4	1.5
Headache pain in last month	3.4	5.8	19.9	2.0	1.2	-0.1	4.5	3.4	-0.1	-2.4	-0.1	-2.4	3.1
Medication for cholesterol, blood pressure or diabetes	1.7	2.7	7.1	0.7	1.4	1.2	2.6	2.2	-0.9	-1.2	-1.1	-1.1	2.7
Glaucoma (self-reported)	1.0	1.2	3.1	0.8	-1.5	-1.8	-0.7	-0.6	-1.3	0.7	-1.5	0.4	-0.6
Gout (self-reported)	0.6	0.9	4.6	0.0	-2.1	-1.7	-0.5	-0.3	-0.6	-0.3	0.5	-0.3	-0.4
Hypothyroidism/myxoedema (self-reported)	9.4	18.4	66.3	0.9	4.1	4.1	3.7	8.1	-0.3	-4.9	1.5	-0.7	6.5
Medication: Amlodipine	1.8	2.5	5.5	-1.0	-1.9	-2.1	-1.2	-1.9	-1.5	0.1	-1.0	-1.5	-2.4
Medication: Ventolin 100micrograms inhaler	1.2	1.5	5.4	0.5	-0.6	-0.6	-2.3	-0.9	0.1	1.1	-0.2	1.9	-1.6
Birth weight	0.6	1.3	5.0	0.7	-0.9	-0.7	-2.2	-0.9	0.8	1.3	0.3	1.3	-1.0
Chronic bronchitis/emphysema (mother)	1.2	1.4	4.4	2.1	-1.3	-1.2	0.0	0.7	-1.2	0.3	-2.0	-0.0	0.5
High blood pressure (siblings)	1.8	2.6	8.1	2.1	-1.5	-1.8	-0.5	-0.7	-1.0	1.7	-2.8	-1.6	-1.0
Forced vital capacity (FVC), Best measure	1.1	3.9	10.3	0.8	0.6	0.6	3.2	2.6	-0.5	-2.3	0.0	-2.2	3.2
Body fat percentage	1.9	7.5	14.3	0.6	-3.1	-2.8	-3.4	-3.5	-1.6	3.8	-1.1	2.2	-3.2
Leg fat percentage (right)	3.3	11.9	19.7	1.4	-4.4	-4.0	-4.0	-4.4	-2.0	4.3	-1.5	2.2	-3.9
Arm fat-free mass (right)	2.2	11.3	25.9	-0.8	-3.1	-2.3	-5.1	-4.7	-0.7	3.2	-0.2	4.4	-4.4
Exposure to tobacco smoke outside home	0.6	0.8	2.9	-1.6	0.1	-0.6	0.5	1.0	0.1	-1.7	0.3	-0.8	0.6
Comparative body size at age 10	4.8	13.4	36.4	-2.4	-4.1	-3.5	-4.0	-6.0	0.2	3.6	-0.3	1.6	-5.5
Number of full brothers	1.6	2.0	6.8	1.0	-1.2	-1.1	-0.8	-2.4	1.2	2.6	-0.6	-0.1	-1.3
Worry too long after embarrassment	11.0	18.4	41.3	0.5	2.9	2.2	6.2	6.2	1.9	-4.8	2.6	-4.3	6.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.7	1.4	0.9	0.1	1.1	1.2	-0.2	1.2	0.2	0.8	0.8	1.1
Wheeze or whistling in the chest in last year	3.0	5.3	10.5	0.2	-2.8	-2.8	-2.3	-3.2	-1.7	2.7	-0.9	1.4	-2.9
Number of children fathered	2.0	2.3	5.9	0.5	-0.7	-1.2	-2.4	-1.5	-1.6	1.5	-1.8	0.5	-2.1
Reason for reducing amount of alcohol drunk: Health precaution	1.3	1.5	3.7	-1.8	1.2	1.9	0.5	1.0	0.7	-1.4	1.0	-0.6	1.3
Age at first live birth	2.7	4.8	9.2	-1.6	2.3	2.2	2.0	2.8	1.7	-3.0	1.8	-0.9	2.8
Pulse wave peak to peak time	1.4	1.6	3.8	-1.1	2.0	1.3	1.4	1.3	-0.1	-1.8	1.1	-0.3	1.0
Health satisfaction	2.5	3.2	8.4	-1.8	-0.6	-1.0	-1.2	-2.9	-1.7	2.1	-1.1	1.9	-2.4
Shortness of breath walking on level ground	0.6	0.7	1.4	-0.5	-0.8	-0.9	-0.6	-0.7	-1.2	1.0	-1.2	0.4	-0.9
Qualifications: College or University degree	0.8	2.5	6.3	-2.4	2.5	2.1	-0.1	1.2	1.5	-1.4	1.7	0.3	0.3
Eye problems/disorders: None of the above	1.0	1.1	5.1	0.0	1.1	0.7	2.3	1.0	0.1	-0.2	0.5	-1.6	0.6
Mouth/teeth dental problems: Loose teeth	3.3	4.0	10.1	1.4	-2.5	-2.7	-1.2	-3.2	-0.4	2.3	-1.2	-0.1	-2.5
Emphysema/chronic bronchitis	6.4	7.2	14.8	2.5	-2.9	-1.8	-3.3	-3.8	-0.7	3.7	-1.8	1.9	-2.7
Medication for pain relief, constipation, heartburn	0.7	1.1	4.0	0.1	0.8	1.2	-0.8	-1.1	1.2	1.2	-0.6	2.0	-0.6
Neck or shoulder pain in last month	0.5	0.8	2.8	0.2	0.8	0.7	1.7	0.9	-0.5	-0.4	-0.7	-0.3	1.4
Medication: Blood pressure	2.4	4.3	12.4	-0.5	-1.3	-0.8	-3.3	-3.3	1.1	2.2	0.4	0.9	-3.5
Angina (self-reported)	0.3	0.4	1.2	-0.7	-1.1	-0.9	-0.6	-0.4	-0.1	0.5	0.4	-0.9	-0.3
Migraine (self-reported)	0.6	0.7	2.4	0.0	-0.7	-0.4	1.5	0.6	0.4	-1.0	-0.2	-1.4	0.6
Medication: Ibuprofen	0.8	1.0	3.6	0.3	0.7	0.7	1.5	1.3	0.0	-0.4	-0.2	-1.9	1.1
Medication: Allopurinol	0.8	1.1	3.6	-0.6	-1.9	-1.6	-1.1	-1.1	0.0	0.2	0.8	-0.0	-1.2
Medication: Omeprazole	0.6	0.8	2.1	0.2	-1.2	-1.4	-0.1	-0.6	-1.4	0.5	-1.0	-0.7	-0.2
Medication: Seretide 50 evohaler	1.1	1.3	2.9	-0.3	0.4	0.5	-0.9	-1.7	1.2	1.2	1.7	1.3	-1.3
Mean time to correctly identify matches	0.4	0.7	5.4	-2.3	0.0	-0.6	0.7	0.0	-0.7	-0.7	0.0	-0.1	-0.2
Heart disease (mother)	0.2	0.3	0.6	0.5	-0.5	-0.2	0.7	0.6	0.5	0.4	0.8	0.4	0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	4.4	5.2	9.9	-0.2	2.7	2.3	2.8	3.2	2.2	-2.0	1.9	-1.5	2.7
Whole body fat mass	2.5	10.4	19.8	0.2	-3.3	-2.7	-4.3	-4.5	-1.2	4.2	-1.0	3.2	-4.2
Leg fat mass (right)	4.3	16.7	31.9	0.5	-4.7	-4.0	-5.2	-5.7	-2.0	4.9	-1.5	3.6	-5.1
Arm predicted mass (right)	2.4	12.3	27.4	-0.7	-3.4	-2.7	-5.2	-5.0	-0.5	3.4	-0.2	4.2	-4.6
Pulse rate, automated reading	0.3	0.9	2.5	1.6	-1.3	-1.3	-1.1	0.3	-1.1	0.3	-0.5	0.2	-0.3
Alcohol intake frequency.	0.2	0.4	1.8	-0.3	-0.2	-0.2	0.2	0.4	-1.3	-0.6	1.0	0.8	0.5
Comparative height size at age 10	0.2	1.0	5.1	0.6	0.1	0.6	-1.6	-0.8	0.4	0.0	0.9	2.2	-0.4
Number of full sisters	2.0	2.5	6.2	-0.3	-2.1	-2.5	-1.3	-1.8	-1.9	1.2	-0.6	0.6	-1.9
Suffer from ‘nerves’	7.2	11.3	32.1	2.1	2.6	1.3	4.9	4.9	0.2	-3.6	0.7	-2.4	5.7
Overall health rating	4.1	8.8	17.1	1.1	-3.1	-3.6	-2.9	-4.1	-2.8	3.5	-1.8	2.1	-3.4
Chest pain or discomfort	0.3	0.4	1.2	1.1	-0.8	-0.3	0.3	-0.2	0.8	1.0	0.4	0.4	0.2
Had major operations	0.3	0.3	1.5	0.1	-0.4	-0.7	0.4	0.1	-1.2	-0.3	0.4	0.8	0.1
Age at last live birth	4.0	5.8	11.9	-0.7	2.4	2.1	2.6	3.4	1.7	-3.5	2.0	-1.2	3.1
Family relationship satisfaction	1.0	1.3	5.7	1.1	0.1	-0.3	2.4	0.6	-1.4	1.0	-0.1	-0.8	1.3
Leg pain on walking	1.9	2.4	4.7	-1.1	-1.7	-2.2	-2.1	-1.3	-1.3	0.8	-1.3	1.5	-1.7
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.5	6.1	0.9	-1.0	-1.5	-0.1	-0.2	-2.5	-0.5	-1.8	-0.1	-0.8
Commuting to job workplace: Car/motor vehicle	1.1	1.3	6.3	0.1	-1.4	-1.5	-0.6	-0.7	0.3	0.6	-0.5	-2.5	-0.9
Illness, injury, bereavement, stress in last 2 years	1.5	1.9	5.0	-0.0	-1.5	-1.2	-2.2	-1.7	-1.2	1.5	-0.5	0.5	-1.6
Medication: Aspirin	2.3	3.1	7.5	-0.5	-2.0	-1.9	-2.4	-2.7	-0.1	2.1	1.1	0.5	-2.0
Supplements: Vitamin C	3.1	3.7	11.3	0.2	-0.2	-0.7	-3.4	-2.5	0.6	1.7	-0.3	2.8	-2.8
Knee pain experienced in last month	0.5	0.7	1.8	-1.0	-1.0	-0.4	0.2	-1.4	0.6	0.9	-0.2	-0.7	-1.2
Hypertension (Self-reported)	5.4	15.1	37.0	0.5	-3.0	-2.9	-5.3	-6.1	-1.6	5.4	-1.6	2.2	-5.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.9	1.1	3.5	1.9	0.2	0.4	-0.5	-0.5	-0.0	1.1	-1.6	1.8	-0.1
Illnesses of father: Heart disease	0.8	1.0	4.9	1.0	1.2	0.2	-0.1	-0.2	-1.0	1.2	-2.2	-0.0	-0.8
Illnesses of siblings: Diabetes	0.8	1.0	2.7	0.1	-0.0	0.4	-0.3	-1.6	1.1	1.6	0.6	0.8	-1.5
Smoking status: Previous	0.4	0.6	1.3	1.1	-0.7	-0.2	-1.1	-0.9	-0.2	1.1	-0.6	-0.5	0.5
Forced expiratory volume in 1-second (FEV1), predicted	1.3	2.7	5.2	1.5	1.4	1.4	1.1	2.3	0.5	-2.2	1.5	1.4	2.2
Whole body fat-free mass	1.8	10.3	22.7	-0.9	-2.8	-1.9	-4.8	-4.7	-0.6	3.1	-0.2	4.4	-4.1
Leg fat-free mass (right)	2.5	13.4	32.7	-1.3	-2.8	-1.9	-4.9	-5.7	-0.4	3.9	-0.4	4.6	-5.2
Arm fat percentage (left)	3.4	13.5	28.0	0.3	-3.9	-3.2	-4.4	-5.3	-1.8	5.2	-1.3	2.8	-4.7
Average weekly red wine intake	2.0	2.9	11.1	-0.4	0.5	0.8	-2.0	-2.1	-0.4	3.3	-1.5	0.6	-2.3
Handedness (chirality/laterality): Left-handed	0.4	0.5	2.0	0.6	0.6	0.4	0.0	-0.5	-1.1	0.9	-1.4	0.3	-0.3
Mood swings	6.1	11.0	27.5	0.3	2.8	1.9	5.1	5.2	0.2	-4.3	0.3	-2.4	4.5
Loneliness, isolation	1.4	2.0	7.6	0.3	0.9	0.6	2.7	1.3	1.2	-1.1	0.7	-1.3	2.1
Long-standing illness, disability or infirmity	0.4	0.5	1.6	-0.3	0.6	0.4	-1.2	-0.7	-0.2	0.2	1.0	1.2	-0.5
Ever had bowel cancer screening	1.2	1.4	4.6	-0.8	1.1	0.5	0.1	1.3	1.5	-2.1	1.9	0.3	0.4
Diabetes diagnosed by doctor	1.4	2.4	5.8	0.2	-2.3	-2.4	-1.6	-1.7	-0.4	0.8	1.1	1.8	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	2.8	3.0	8.5	0.1	-0.7	-1.1	-2.2	-2.9	-0.2	1.8	-0.7	1.7	-2.9
Friendships satisfaction	1.5	1.9	7.8	-0.1	-1.7	-2.8	1.8	-0.0	-1.9	-0.5	-0.3	-0.9	0.3
Qualifications: nursing, teaching	1.5	2.4	6.8	-1.6	2.6	2.6	-0.4	0.5	2.0	-1.1	1.1	-0.6	0.6
Commuting to job workplace: Walk	1.7	1.8	7.8	-2.8	1.3	1.2	0.0	-0.2	0.0	-0.8	0.4	2.3	-0.8
Eye problems/disorders: Cataract	0.8	1.0	4.1	-0.1	-1.0	-0.5	-1.7	-0.2	-0.8	0.2	0.4	2.0	-0.7
Mouth/teeth dental problems: Mouth ulcers	1.2	1.9	5.2	-0.4	1.0	0.4	1.8	2.0	1.3	-2.3	0.9	-1.2	1.2
Medication for cholesterol	3.2	4.8	6.7	-1.6	2.1	2.3	2.5	2.4	2.4	-2.6	1.8	-1.5	2.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.2	0.2	0.6	0.4	-0.3	-0.1	0.2	-0.3	-0.8	-0.5	-0.2	0.4	-0.7
Back pain experienced in last month	0.8	1.2	4.3	1.3	-1.3	-2.1	-0.3	-0.2	-1.0	-0.4	-1.4	-0.8	-0.3
Mineral and other dietary supplements	4.0	5.4	16.4	0.8	0.2	0.1	2.4	4.1	-2.8	-3.1	-1.5	-1.7	2.9
Breast cancer (self-reported)	1.8	2.2	11.9	0.0	1.3	1.3	-0.9	-0.4	3.5	0.7	1.2	1.8	-0.5
Asthma (self-reported)	2.2	4.3	13.4	0.1	-0.1	-0.3	-2.7	-3.3	-0.5	2.8	-0.8	1.8	-3.7
Osteoporosis (self-reported)	3.5	4.4	13.4	-0.5	2.1	2.0	2.1	3.7	1.5	-1.8	2.0	-0.4	2.7
Osteoarthritis (self-reported)	1.0	1.3	2.4	-0.4	-1.4	-1.3	-1.2	-0.8	-1.2	0.5	-0.6	1.6	-1.5
Medication: Aspirin	1.9	2.5	5.6	-0.6	-2.2	-2.2	-1.7	-2.4	-0.1	1.6	1.3	-0.0	-1.5
Medication: Gliclazide	0.7	0.7	1.7	-0.9	-1.2	-0.9	-0.7	-0.5	-1.3	-0.3	-0.4	-1.0	-0.8
Illnesses of father: None of the above (group 1)	0.9	1.1	3.2	1.0	-0.9	-0.1	0.9	1.8	-0.1	-1.5	0.3	-0.3	1.6
Smoking status: Current	4.4	6.9	14.0	0.6	-3.2	-2.3	-2.3	-3.7	-2.5	2.9	-2.6	0.7	-3.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.2	4.6	13.0	0.8	0.5	0.7	2.2	3.6	0.6	-2.7	0.7	-2.4	3.6
Whole body water mass	1.8	10.4	23.0	-0.9	-2.7	-1.9	-4.8	-4.8	-0.5	3.1	-0.2	4.3	-4.1
Leg predicted mass (right)	2.5	13.5	32.5	-1.3	-2.8	-2.0	-5.0	-5.7	-0.4	3.9	-0.3	4.6	-5.3
Arm fat mass (left)	4.0	16.3	34.2	0.2	-4.2	-3.3	-5.1	-5.8	-1.9	5.4	-1.6	3.4	-5.2
Number of self-reported non-cancer illnesses	0.4	0.7	1.6	0.7	0.4	0.6	-1.2	-0.3	1.2	0.6	1.3	0.8	-0.6
Average weekly champagne plus white wine intake	1.0	1.3	3.3	0.1	0.5	0.1	-1.3	-0.7	1.7	0.8	1.3	1.8	-1.5
Miserableness	8.6	14.8	39.4	0.7	1.9	1.1	6.0	6.3	1.1	-5.0	2.1	-2.5	5.5
Guilty feelings	6.8	10.3	24.4	0.8	2.6	2.4	4.1	4.9	1.9	-3.6	1.2	-2.8	4.8
Wears glasses or contact lenses	1.2	1.4	7.1	-2.7	1.4	0.9	-0.1	0.5	1.2	-0.6	1.2	0.6	0.3
Ever taken oral contraceptive pill	0.5	0.5	2.1	-0.4	1.0	0.5	0.6	1.0	0.0	-1.5	-0.2	0.7	-0.0
Hearing aid user	0.2	0.2	0.8	0.4	0.1	0.0	-0.9	-0.1	0.3	0.7	0.1	0.7	-0.6
Mother’s age at death	1.9	2.4	5.7	-0.3	1.6	1.3	2.4	2.1	0.7	-1.2	0.8	-1.7	2.1
Financial situation satisfaction	0.8	1.0	2.4	-0.1	-1.4	-1.3	-0.7	-1.2	-1.6	0.9	-0.6	0.7	-0.5
Tinnitus: Yes, now most or all of the time	0.8	1.0	2.8	0.6	-0.2	-0.1	0.8	1.7	0.5	-1.2	1.0	-0.9	1.4
Commuting to job workplace: Public transport	2.1	2.5	6.4	-0.1	1.8	1.5	2.5	2.4	-0.2	-1.7	0.9	-0.2	1.9
Eye problems/disorders: Glaucoma	1.9	2.2	5.3	1.2	-1.9	-2.0	-1.5	-1.2	-1.7	1.0	-2.3	0.4	-0.8
Medication: Blood pressure	5.7	10.9	27.0	0.2	-2.7	-3.0	-4.5	-5.2	-2.2	3.8	-1.8	2.2	-4.3
Pain type(s) experienced in last month: Hip pain	1.2	1.5	3.5	-0.1	-1.1	-1.3	-1.7	-1.3	-0.7	1.1	-0.6	1.4	-1.9
Supplements: Fish oil (including cod liver oil)	4.3	5.7	18.4	1.0	-1.8	-1.9	-2.5	-4.3	0.7	3.6	-0.8	0.3	-3.3
High cholesterol (Self-reported)	1.6	2.9	7.1	0.3	-2.7	-2.6	-2.3	-1.7	-0.7	0.9	-0.1	1.8	-1.3
Medication: Bendroflumethiazide	6.1	9.3	23.9	-0.8	-2.9	-3.3	-3.6	-4.9	-1.3	3.2	-2.1	0.6	-4.4
Medication: Paracetamol	2.2	3.5	9.8	0.7	-1.1	-2.0	2.2	2.2	-1.9	-1.9	-0.4	-3.1	1.2
Medication: Lisinopril	1.4	1.7	5.6	0.3	-1.3	-1.6	-1.1	-2.4	-0.7	1.5	-0.3	-0.7	-1.7
Medication: Atorvastatin	0.6	0.7	3.1	-0.9	-1.2	-0.7	-0.0	-0.1	-1.8	0.1	-1.1	-0.1	0.0
Illnesses of father: High blood pressure	0.7	0.8	2.4	-0.4	-0.3	-1.4	-0.7	-1.6	0.0	0.9	-0.6	-0.5	-1.4
Alcohol drinker status: Never	1.7	2.0	6.4	-1.1	1.4	1.8	0.3	1.4	1.3	-1.0	2.5	1.2	1.2
Ever smoked	1.5	2.7	6.5	2.6	-1.8	-1.4	-1.0	-1.0	-2.1	1.6	-2.4	-0.7	-0.0
Basal metabolic rate	2.0	11.3	24.9	-0.7	-3.0	-2.2	-4.8	-5.0	-0.8	3.5	-0.4	4.3	-4.3
Leg fat percentage (left)	3.3	11.9	20.0	1.4	-4.4	-4.0	-4.2	-4.5	-1.6	4.2	-1.3	2.3	-4.2
Arm fat-free mass (left)	2.1	10.5	23.9	-0.5	-3.3	-2.6	-4.9	-4.7	-0.9	3.0	-0.4	3.9	-4.0
Number of operations (self-reported)	2.7	4.0	10.4	-0.4	-1.1	-1.1	-2.8	-2.7	-1.6	1.8	-1.3	2.1	-3.2
Average weekly beer plus cider intake	4.7	6.9	20.4	1.6	0.4	0.1	2.8	4.5	-0.9	-4.5	-0.2	-1.9	3.7
Irritability	15.5	26.3	64.0	1.9	3.1	1.6	6.4	8.0	0.3	-7.3	2.3	-5.2	7.6
Risk taking	3.4	4.9	9.5	1.3	-2.4	-3.0	-2.1	-3.1	-1.1	2.2	-1.9	0.5	-3.0
Ever had prostate specific antigen (PSA) test	0.4	0.4	1.3	-0.7	-0.3	-1.1	-0.4	0.2	-0.7	-0.4	-0.7	-0.7	-0.7
Fractured/broken bones in last 5 years	2.1	2.7	8.0	-1.4	0.8	0.4	1.5	1.3	2.7	-2.1	2.8	-0.2	0.7
Age started oral contraceptive pill	0.9	1.2	3.6	-0.2	1.9	1.6	0.2	1.6	0.4	-0.8	0.6	1.0	0.8
Diastolic blood pressure, automated reading	6.4	19.9	42.8	0.5	-3.8	-4.1	-5.1	-6.5	-2.0	6.5	-3.2	1.6	-6.3
Ever depressed for a whole week	2.0	2.5	5.1	-1.0	2.0	1.6	2.2	2.3	1.1	-1.6	1.1	0.3	1.6
Unable to work because of sickness or disability	2.3	3.0	5.7	0.6	-1.6	-2.0	-1.1	-2.3	-2.0	2.4	-2.2	-0.0	-1.4
Commuting to job workplace: Cycle	0.3	0.3	1.2	-1.0	1.1	0.5	0.5	-0.0	-0.2	0.1	-0.2	-0.5	0.5
Myopia	1.9	2.8	7.0	1.1	1.4	1.4	2.6	1.6	2.4	-1.4	1.5	-1.1	1.5
Vascular/heart problems diagnosed by doctor	4.4	11.9	28.0	0.3	2.5	2.7	4.9	5.3	1.9	-4.4	1.3	-2.0	5.0
Cholesterol lowering medication	1.1	1.6	6.7	1.5	-2.2	-2.6	-0.7	0.3	-1.3	0.2	-0.6	0.1	0.1
Medication: Omeprazole (e.g. Zanprol)	0.6	0.7	2.6	-0.0	-1.1	-1.3	0.4	-0.1	-1.6	-0.1	-0.6	-0.9	0.2
Pain experienced in last month	0.6	1.1	2.3	-1.5	1.5	1.2	-1.2	0.0	0.8	-0.2	1.1	0.9	-0.6
Supplements: Calcium	1.6	1.8	7.8	-0.9	1.0	1.2	-0.7	0.1	1.8	-0.3	1.6	2.8	-0.6
Basal cell carcinoma (self-reported)	0.2	0.3	0.7	-0.4	0.0	-0.1	-0.4	-0.3	-0.8	0.4	-0.6	0.8	-0.7
Heart attack/myocardial infarction (self-reported)	1.0	1.3	3.3	-0.1	-1.8	-1.8	-0.6	0.4	-1.8	-1.0	1.0	-0.4	0.9
Deep venous thrombosis (DVT) (self-reported)	2.0	2.6	8.8	-1.1	-1.5	-0.5	-3.0	-2.1	-0.9	2.0	0.2	1.2	-1.8
Heart disease (siblings)	0.4	0.5	1.5	-0.4	-0.8	-1.1	0.3	1.2	-0.6	-0.8	0.5	0.6	-0.5
Alcohol drinker status: Previous	0.2	0.3	1.3	0.6	-0.2	-0.3	-0.4	0.0	-1.1	-0.5	-0.5	0.6	-0.3
Pack years of smoking	1.4	2.0	4.2	0.6	-1.8	-1.4	-2.1	-1.7	-0.5	1.6	0.1	1.5	-1.7
Impedance of whole body	6.8	34.6	93.8	2.0	5.3	4.7	6.9	9.7	0.8	-7.0	1.9	-4.3	8.8
Leg fat mass (left)	4.2	16.3	31.1	0.4	-4.6	-3.9	-5.2	-5.6	-1.9	4.8	-1.3	3.6	-5.2
Arm predicted mass (left)	2.2	11.4	23.7	-0.5	-3.5	-2.9	-4.8	-4.9	-1.1	3.2	-0.6	4.1	-4.2