Hub : Genes

PPP1R3B

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 NTR Blood 0.0268 0.0122 1.5e-04 0.023 0.008 0.021 0.016 0.019 5.0e-08 1.3e-03 1.5e-07 6.2e-06 4.6e-07
2 TCGA Breast Invasive Carcinoma 0.0277 0.0117 6.4e-06 0.025 0.027 0.028 NA 0.026 5.0e-06 2.2e-06 1.8e-06 NA 3.4e-06
3 TCGA Prostate Adenocarcinoma 0.0633 0.0340 4.6e-03 0.014 0.021 0.016 NA 0.015 1.2e-02 2.6e-03 7.3e-03 NA 1.0e-02
4 TCGA Thyroid Carcinoma 0.0620 0.0330 2.1e-03 0.019 0.015 0.029 NA 0.025 5.0e-03 1.1e-02 8.0e-04 NA 1.7e-03

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.1 1.7 3.6 1.4 -1.9 -0.6 -1.0
Bipolar Disorder or Schizophrenia 5.8 14.2 20.6 3.5 -4.3 -2.3 -4.5
Depressed Affect (Nagel 2018) 1.5 3.1 4.5 -1.5 1.4 2.1 1.9
Depression (Nagel 2018) 1.7 2.6 7.9 -0.6 0.6 2.8 1.3
Intelligence (Savage-Jansen 2018) 0.1 0.4 1.2 -0.5 1.1 0.4 0.2
Neuroticism (Nagel 2018) 0.7 1.6 3.5 -1.0 0.8 1.9 1.1
Schizophrenia (2018) 7.2 15.0 25.4 3.3 -4.1 -2.6 -5.0
Schizophrenia vs Biploar Disorder 1.7 2.3 7.7 0.8 -0.5 -0.7 -2.8
Worry (Nagel 2018) 0.5 1.2 3.0 -0.8 0.8 1.7 -0.5
Alzheimer’s Disease (in mother) 0.2 0.3 0.6 -0.0 -0.2 0.7 -0.7
Alzheimer’s Disease (in father) 0.8 0.9 1.7 -0.4 -1.2 -1.3 0.2
Alzheimer’s Disease (including proxy) 0.3 0.5 1.3 -1.1 -0.3 0.7 -0.1
Crohns Disease (2017) 0.3 0.7 2.0 0.2 0.4 0.8 -1.4
Irritable Bowel Disease (IBD) 0.6 1.3 2.2 -0.9 1.5 1.5 -0.3
Ulcerative Colitis (UC) 0.7 1.3 2.2 -1.1 1.2 1.5 0.5
Major Depression (MDD) 0.4 0.5 1.1 -1.0 0.5 0.7 -0.1
Reaction Time 0.3 0.6 1.4 0.7 -0.5 -0.3 1.2
Verbal and Numeric Reasoning (VNR) 0.7 1.8 4.6 -1.3 2.2 0.5 0.8
Breast Cancer 2.1 5.2 8.3 2.5 -1.6 -1.9 -2.9
Ovarian Cancer 1.1 1.5 3.7 0.9 -1.9 -0.6 -1.1
Prostate Cancer 0.4 0.6 1.8 0.7 -0.3 -0.3 -1.3
Age at First Birth 0.7 1.0 2.0 -0.7 0.9 1.4 0.7
Bipolar Disorder (2011) 0.0 0.0 0.2 0.4 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 3.8 5.2 9.3 2.3 -3.0 -1.1 -2.2
Coronary Artery Disease (CAD) 0.9 1.1 2.4 1.3 -0.5 -1.5 0.0
Crohns Disease (2012) 0.1 0.2 0.5 -0.0 -0.4 0.5 -0.7
Mean Putamen Volume 0.3 0.4 1.0 0.6 -0.1 -1.0 -0.3
Fasting Glucose 0.7 0.8 1.6 0.2 1.2 1.3 -0.3
HbA1C 0.3 0.3 0.7 -0.2 -0.7 -0.4 -0.8
HDL Cholesterol 1.4 2.3 3.7 1.7 -1.9 -1.5 0.4
LDL Cholesterol 1.5 2.3 4.0 2.0 -1.8 -1.0 -1.0
Lupus 9.0 13.7 18.7 3.2 -4.1 -3.0 -4.3
Neuroticism (2016) 12.4 17.9 31.5 -3.5 4.6 2.5 5.6
Primary Biliary Cirrhosis 1.6 2.3 4.6 1.4 -1.6 0.3 -2.1
Rheumatoid Arthritis 0.2 0.3 1.1 -0.2 -1.1 0.2 0.3
Schizophrenia (2014) 7.5 16.4 22.7 3.9 -4.2 -3.2 -4.8
Triglycerides 5.7 9.3 12.5 -3.5 3.1 2.8 2.8
Type 2 Diabetes (T2D) (2012) 0.6 0.6 1.0 0.9 -0.9 -1.0 -0.2
Ulcerative Colitis 3.0 4.4 5.2 -2.1 1.9 2.2 2.3
Blood Eosinophil Count 0.3 2.6 4.2 1.2 -2.1 -1.8 1.1
Blood Platelet Count 0.2 2.4 5.3 1.3 -1.6 -2.3 0.4
Blood Red Count 0.4 4.2 9.5 2.1 -1.6 -3.1 -0.6
Blood White Count 0.1 0.7 2.2 -0.1 -0.7 0.2 1.5
Heel T-Score 1.3 10.5 14.7 2.7 -3.5 -3.8 -2.8
BMI 0.7 3.9 5.1 2.3 -2.1 -1.9 1.6
Height 0.1 2.9 8.0 -0.4 2.8 1.8 0.4
Waist Hip Ratio (WHR) 0.8 3.7 6.5 -1.9 2.5 1.2 1.9
Systolic Blood Pressure 0.3 1.7 4.3 1.1 -0.5 -2.1 0.9
Smoking Status 0.1 0.3 1.2 0.0 -1.1 0.3 0.1
Allergy or Eczema 0.0 0.0 0.1 0.1 0.1 0.1 -0.3
Cardiovascular Disease 0.4 1.3 4.8 -0.3 -0.6 -0.0 2.2
Hypothyroidism (self reported) 0.0 0.1 0.3 -0.5 0.0 -0.1 -0.1
Respiratory disease 1.2 2.8 6.9 0.9 -2.6 -1.8 0.1
Type 2 Diabetes (T2D) (2018) 0.3 0.6 1.3 1.1 0.9 0.5 -0.2
Lung FEV1/FVC ratio 5.3 27.1 43.9 -5.6 5.6 6.6 1.4
Lung FVC 0.0 0.2 0.3 -0.3 0.1 -0.4 -0.6
Neuroticism 0.5 1.2 3.8 -0.3 0.8 1.9 -0.6
Chronotype (morning person) 0.5 1.1 3.0 1.7 -0.7 -0.3 -0.9
Hair Pigment 0.5 14.6 20.2 -4.3 4.3 4.5 1.3
Tanning 0.3 3.3 5.2 2.3 -1.8 -2.2 -0.3
Hand grip strength (left) 0.1 0.4 1.3 0.2 -0.3 -0.4 -1.1
Number of treatments/medications taken 0.3 0.6 1.8 -0.0 0.7 1.3 0.4
Average weekly spirits intake 1.3 1.7 4.1 0.3 1.4 -0.8 2.0
Sensitivity / hurt feelings 9.6 16.4 21.5 -3.8 3.9 4.6 3.7
Frequency of depressed mood in last 2 weeks 9.6 13.5 17.0 -4.0 3.5 4.1 2.9
Hearing difficulty/problems: Yes 0.7 1.1 2.6 0.2 1.6 1.3 0.4
Relative age of first facial hair 1.0 2.0 3.6 1.1 -1.9 -1.8 -0.1
Other serious medical condition/disability diagnosed by doctor 0.5 0.7 1.3 -0.7 0.5 0.7 1.2
Ever used hormone-replacement therapy (HRT) 0.1 0.1 0.2 -0.2 0.5 -0.1 0.3
Ever had hysterectomy (womb removed) 2.8 3.1 3.8 1.3 -1.8 -2.0 -1.9
Systolic blood pressure, automated reading 8.9 25.9 38.2 6.2 -5.3 -5.0 -3.6
Eye problems/disorders: Diabetes related eye disease 0.4 0.4 0.7 -0.5 0.8 0.7 -0.6
Angina 0.2 0.2 0.3 -0.3 -0.6 0.5 0.5
Medication for hormone replacement therapy 0.6 0.7 1.5 -0.8 0.1 0.7 -1.2
Vitamin and mineral supplements 2.2 3.0 6.3 -2.5 1.9 1.3 0.4
Supplements: Zinc 0.8 0.9 1.8 0.7 -1.3 -0.9 -0.7
Medication: Co-codamol 0.2 0.2 0.6 0.1 0.5 0.2 -0.8
Medication: Metformin 1.8 2.6 8.9 1.1 0.2 0.3 -3.0
Diabetes (father) 1.2 1.5 3.7 0.5 -1.2 -0.7 -1.9
Diabetes (mother) 1.3 1.7 2.9 1.4 -1.5 -1.7 -0.1
Severe depression (siblings) 3.6 4.1 6.5 -2.2 2.1 2.5 -0.6
Pack years adult smoking proportion 1.3 2.0 5.4 0.3 -1.6 -0.3 -2.3
Impedance of leg (right) 6.9 33.3 52.3 -5.9 5.7 3.7 7.2
Leg fat-free mass (left) 3.0 15.7 22.7 4.6 -3.5 -2.5 -4.8
Trunk fat percentage 1.7 7.0 10.5 3.2 -3.2 -2.3 -1.3
Hand grip strength (right) 0.2 0.5 1.6 0.4 0.5 0.3 -1.3
Townsend deprivation index at recruitment 0.8 1.1 2.0 -0.7 1.2 1.4 -0.7
Current tobacco smoking 5.0 8.1 16.4 1.5 -3.1 -2.0 -4.0
Average weekly fortified wine intake 2.7 3.1 6.3 -1.6 1.8 0.5 2.5
Maternal smoking around birth 0.4 0.6 0.9 1.0 0.4 -0.7 1.0
Fed-up feelings 10.9 19.9 21.1 -4.6 4.5 4.5 4.3
Frequency of unenthusiasm / disinterest in last 2 weeks 5.7 7.6 15.2 -2.3 2.7 3.9 1.6
Relative age voice broke 0.3 0.4 0.8 -0.1 -0.4 -0.8 0.9
Taking other prescription medications 0.2 0.4 1.1 -0.1 0.2 0.6 1.0
Age when periods started (menarche) 1.7 4.0 9.3 -1.8 3.0 1.8 0.6
Bilateral oophorectomy (both ovaries removed) 0.7 0.8 2.7 0.3 -0.7 -1.6 0.2
Heel bone mineral density (BMD) T-score, automated (left) 26.0 59.1 64.8 8.0 -8.0 -6.8 -7.8
Tinnitus: Yes, but not now, but have in the past 0.6 0.7 1.5 1.2 -0.0 -0.4 -1.0
Qualifications: CSEs or equivalent 0.3 0.3 0.6 -0.1 0.6 0.8 -0.6
Serious illness, injury or assault to yourself 0.7 0.8 2.0 -0.1 0.9 0.7 1.4
High blood pressure 4.6 12.8 18.4 3.2 -4.2 -2.2 -4.3
Hayfever, allergic rhinitis or eczema 0.3 0.6 1.6 0.7 -0.3 -0.4 -1.2
Multivitamins +/- minerals 1.4 1.8 3.4 1.3 -1.8 -1.5 0.1
Stomach or abdominal pain in last month 4.5 5.6 8.1 -2.8 2.4 1.3 2.6
Supplements: Glucosamine 0.6 0.8 2.5 0.2 0.6 -0.4 1.6
Diverticular disease/diverticulitis (self-reported) 0.7 0.9 1.7 0.5 -1.1 -1.3 -0.6
Medication: Atenolol 1.4 1.7 3.2 1.4 -1.8 -0.8 -1.1
Medication: Levothyroxine sodium 7.0 11.9 21.2 -3.2 3.4 2.2 4.6
Sitting height 3.9 28.0 41.3 6.4 -4.0 -5.1 -5.4
Chronic bronchitis/emphysema (father) 0.7 0.8 2.2 -1.5 0.7 0.7 0.4
High blood pressure (mother) 1.9 2.7 4.5 2.1 -1.2 -1.6 -1.5
Body mass index (BMI) 8.0 34.3 43.8 6.6 -6.5 -4.7 -5.4
Impedance of leg (left) 6.6 31.9 52.0 -5.8 5.4 3.5 7.2
Leg predicted mass (left) 2.9 15.5 22.9 4.5 -3.5 -2.4 -4.8
Trunk fat mass 2.5 10.6 18.0 4.2 -3.6 -2.7 -2.2
Waist circumference 0.9 3.3 6.9 2.6 -1.9 -1.5 -0.8
Number of incorrect matches in round 1.0 1.6 2.8 -0.5 1.1 1.7 1.4
Past tobacco smoking 2.9 5.4 8.3 -2.9 2.4 2.5 1.1
Alcohol usually taken with meals 1.4 2.3 4.7 2.2 -1.5 -1.4 -0.5
Nervous feelings 14.8 27.7 31.1 -5.2 5.6 5.0 5.2
Frequency of tenseness / restlessness in last 2 weeks 1.3 2.0 2.7 -1.6 0.8 1.5 1.6
Hearing difficulty/problems with background noise 0.6 1.0 2.2 -0.5 1.0 0.6 1.5
Hair/balding pattern: Pattern 2 0.3 0.4 1.0 0.4 -0.6 -1.0 -0.4
Had menopause 0.4 0.5 1.0 0.6 -0.8 -1.0 -0.3
Had other major operations 1.8 2.2 2.9 1.6 -1.7 -1.0 -1.5
Forced vital capacity (FVC) 0.9 3.3 6.1 -1.4 2.5 1.4 1.7
Heel bone mineral density (BMD) T-score, automated (right) 25.0 57.4 64.8 8.0 -8.0 -6.2 -8.1
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 0.9 -0.9 0.3 1.0 -0.2
Qualifications: None of the above 0.0 0.1 0.2 -0.1 -0.4 0.3 -0.2
Financial difficulties in last 2 years 1.0 1.4 1.7 1.3 -1.3 -1.2 -0.8
Mouth/teeth dental problems 3.0 4.5 7.7 -2.1 2.8 1.6 1.8
Heart attack 0.2 0.3 0.6 -0.2 -0.1 0.7 0.8
Allergy 0.9 2.0 2.5 -1.6 1.4 1.1 1.5
Pain all over the body in last month 1.5 1.6 2.4 1.5 -0.8 -1.0 -1.5
Diabetes (self-reported) 0.8 1.2 3.7 0.8 0.6 0.5 -1.9
Hayfever/allergic rhinitis (self-reported) 0.4 0.5 0.9 -0.8 0.7 0.5 1.0
Medication: Ramipril 1.1 1.4 3.3 0.5 -1.1 -0.9 -1.8
Medication: Simvastatin 0.7 1.0 2.3 1.5 -0.6 -0.6 -0.9
Fluid intelligence score 0.8 1.6 4.3 -0.8 2.1 0.6 1.1
Illnesses of siblings 0.9 1.2 2.5 -1.5 0.4 0.1 1.6
Neuroticism score 17.1 35.6 39.8 -6.1 6.3 5.6 5.9
Weight 2.9 14.3 24.3 4.9 -3.7 -2.6 -3.5
Impedance of arm (right) 8.7 40.7 49.3 -7.0 6.5 4.8 6.9
Arm fat percentage (right) 4.0 15.7 22.1 4.7 -4.6 -3.2 -3.0
Trunk fat-free mass 1.0 6.0 12.5 3.5 -1.3 -1.2 -2.9
Hip circumference 4.0 17.2 28.9 5.4 -4.4 -3.3 -3.1
Time employed in main current job 1.9 2.1 4.3 -1.6 1.1 0.7 2.1
Alcohol intake versus 10 years previously 0.8 1.3 4.9 -0.2 -2.2 0.0 -0.4
Father’s age at death 3.9 5.2 7.2 -2.4 2.6 0.9 2.7
Worrier / anxious feelings 18.2 34.4 37.6 -6.1 6.1 5.1 6.1
Frequency of tiredness / lethargy in last 2 weeks 2.4 4.0 8.3 -1.8 1.1 2.9 1.7
Falls in the last year 0.5 0.7 2.1 -0.0 -0.8 0.2 -1.5
Hair/balding pattern: Pattern 3 2.5 3.8 7.2 -1.3 2.7 2.3 0.9
Number of live births 0.1 0.1 0.3 0.0 -0.5 0.2 -0.3
Forced expiratory volume in 1-second (FEV1) 3.9 13.0 18.4 -3.3 4.3 3.1 3.6
Pulse rate 0.9 1.5 2.9 -1.0 1.7 1.5 0.2
Happiness 0.5 0.6 1.1 -1.1 -0.0 0.9 0.6
Noisy workplace 0.7 0.9 1.7 -1.3 0.0 0.8 1.0
Qualifications: A levels/AS levels or equivalent 0.6 1.2 3.3 -0.3 1.8 -0.4 1.1
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 2.2 -1.1 1.4 0.9 1.5
Mouth/teeth dental problems: Dentures 3.8 6.5 9.7 2.1 -3.1 -2.1 -2.7
Asthma 2.8 5.6 10.5 2.1 -3.2 -2.3 -1.5
Medication: Ibuprofen (e.g. Nurofen) 3.5 4.4 7.3 -2.4 1.8 2.7 1.1
Medication: Cholesterol lowering 0.8 1.3 2.7 1.6 -1.3 -0.6 -0.6
Depression (self-reported) 2.3 2.7 4.2 -2.1 1.4 1.7 1.4
Medication: Lansoprazole 1.5 1.8 3.2 -1.8 1.0 1.6 0.4
Prospective memory result 0.6 0.7 1.5 1.2 -0.9 -0.7 -0.3
Lung cancer (father) 0.3 0.3 0.8 -0.9 0.3 0.3 0.6
Illnesses of mother 0.5 0.6 2.2 -0.4 -0.2 0.4 -1.5
Forced expiratory volume in 1-second (FEV1), Best measure 3.8 12.2 16.2 -3.7 4.0 3.3 2.8
Pulse wave Arterial Stiffness index 2.5 2.9 5.1 2.3 -1.0 -1.9 -1.3
Impedance of arm (left) 7.9 36.5 48.3 -7.0 6.2 4.5 6.3
Arm fat mass (right) 4.7 19.5 29.2 5.4 -4.7 -3.4 -3.9
Trunk predicted mass 1.0 5.9 12.2 3.5 -1.3 -1.3 -2.8
Standing height 1.7 17.1 32.7 -3.0 5.7 3.9 3.4
Length of working week for main job 1.6 1.7 3.3 0.6 -1.8 -1.5 -1.0
Exposure to tobacco smoke at home 0.4 0.5 1.7 -0.0 0.4 0.0 -1.3
Breastfed as a baby 1.5 1.9 3.4 -1.9 1.6 0.4 1.2
Tense / ‘highly strung’ 10.6 17.5 21.7 -4.7 4.5 4.3 3.0
Seen doctor (GP) for nerves, anxiety, tension or depression 3.3 5.0 7.2 -2.7 2.1 2.4 1.6
Hair/balding pattern: Pattern 4 0.4 0.9 1.8 -0.0 1.3 0.1 1.3
Birth weight of first child 2.2 3.9 9.2 -1.5 2.0 3.0 0.3
Peak expiratory flow (PEF) 6.3 14.5 26.1 -3.9 3.2 2.7 5.1
Pulse wave reflection index 1.2 1.5 2.9 1.1 -1.2 -1.7 -0.6
Ever highly irritable/argumentative for 2 days 1.8 2.1 3.4 -1.4 1.9 1.3 1.2
Loud music exposure frequency 0.6 0.6 0.8 0.9 -0.9 -0.3 -0.9
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 2.7 -1.2 1.6 0.5 1.5
Mouth/teeth dental problems: Bleeding gums 4.8 6.2 8.1 2.6 -2.6 -2.8 -1.8
Blood clot in the leg (DVT) 0.3 0.4 0.7 0.8 0.8 0.4 -0.6
Medication: Paracetamol 4.3 7.1 12.4 -2.1 2.7 2.1 3.5
Headache pain in last month 12.3 21.1 29.2 -4.5 4.9 5.4 3.2
Medication for cholesterol, blood pressure or diabetes 1.9 3.1 5.5 -1.7 2.0 0.5 2.3
Glaucoma (self-reported) 0.7 0.8 1.5 1.2 -0.3 -1.2 0.5
Gout (self-reported) 0.6 0.9 1.3 1.0 -1.1 -1.0 0.5
Hypothyroidism/myxoedema (self-reported) 11.1 21.7 25.7 -5.0 4.9 3.5 5.1
Medication: Amlodipine 1.2 1.7 4.8 0.5 -1.3 0.5 -2.2
Medication: Ventolin 100micrograms inhaler 2.4 3.0 6.7 1.7 -2.6 -1.4 -0.8
Birth weight 0.4 0.9 2.0 -0.3 -0.3 1.4 -1.2
Chronic bronchitis/emphysema (mother) 0.6 0.7 1.5 -0.2 0.1 -1.2 1.2
High blood pressure (siblings) 0.9 1.3 2.4 1.5 -0.8 0.2 -1.5
Forced vital capacity (FVC), Best measure 0.4 1.5 2.8 -1.4 1.7 0.8 0.8
Body fat percentage 2.8 11.2 16.5 4.1 -4.0 -2.9 -1.9
Leg fat percentage (right) 4.5 16.2 24.1 4.9 -4.7 -3.5 -2.4
Arm fat-free mass (right) 2.7 13.9 23.2 4.8 -3.2 -2.9 -3.8
Exposure to tobacco smoke outside home 0.4 0.5 1.3 1.1 0.5 -0.7 -0.1
Comparative body size at age 10 8.8 24.4 31.9 5.3 -4.9 -3.6 -5.7
Number of full brothers 6.5 8.1 11.0 2.6 -3.0 -3.3 -2.4
Worry too long after embarrassment 5.9 9.9 17.6 -2.7 3.1 2.3 4.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.3 0.3 0.8 -0.1 0.2 0.7 0.9
Wheeze or whistling in the chest in last year 3.9 7.0 10.8 2.2 -3.3 -1.4 -3.2
Number of children fathered 0.5 0.6 1.4 0.9 -1.2 -0.2 -0.4
Reason for reducing amount of alcohol drunk: Health precaution 0.1 0.1 0.3 0.4 -0.5 -0.3 0.1
Age at first live birth 4.1 7.2 11.3 -3.4 3.0 2.0 2.1
Pulse wave peak to peak time 3.0 3.5 5.4 -2.3 1.3 2.2 1.5
Health satisfaction 0.9 1.2 3.4 0.3 -0.4 1.1 -1.8
Shortness of breath walking on level ground 1.0 1.2 2.6 -0.5 0.4 1.3 -1.6
Qualifications: College or University degree 0.3 1.0 2.8 -0.7 1.7 0.4 0.8
Eye problems/disorders: None of the above 0.6 0.7 1.6 1.0 0.2 -0.1 1.3
Mouth/teeth dental problems: Loose teeth 2.4 2.9 6.1 1.1 -1.9 0.6 -2.5
Emphysema/chronic bronchitis 4.8 5.4 8.5 1.9 -2.7 -1.4 -2.9
Medication for pain relief, constipation, heartburn 3.0 5.1 6.4 2.1 -2.3 -2.5 -2.2
Neck or shoulder pain in last month 0.3 0.4 1.0 0.6 -1.0 -0.2 0.4
Medication: Blood pressure 3.1 5.5 10.6 2.2 -2.4 -0.7 -3.3
Angina (self-reported) 0.1 0.2 0.4 -0.1 -0.6 0.4 0.4
Migraine (self-reported) 5.4 6.7 9.3 -3.0 2.9 2.9 1.0
Medication: Ibuprofen 3.6 4.3 8.4 -2.3 1.4 2.9 1.3
Medication: Allopurinol 0.5 0.7 1.4 1.2 -0.7 -0.9 0.1
Medication: Omeprazole 0.5 0.6 1.8 0.3 0.6 1.4 -0.1
Medication: Seretide 50 evohaler 0.9 1.0 1.5 1.1 -1.2 -1.0 -0.5
Mean time to correctly identify matches 0.5 0.9 2.4 1.6 -0.9 -0.5 0.1
Heart disease (mother) 1.0 1.3 3.5 0.4 1.2 -0.0 1.9
Reproduciblity of spirometry measurement using ERS/ATS criteria 4.1 4.9 11.5 -2.1 1.2 1.6 3.4
Whole body fat mass 3.6 14.9 22.9 4.8 -4.2 -3.2 -2.9
Leg fat mass (right) 5.4 21.0 31.5 5.6 -5.0 -3.9 -3.6
Arm predicted mass (right) 2.9 14.7 25.2 5.0 -3.3 -2.7 -3.9
Pulse rate, automated reading 0.3 1.0 2.3 0.6 -1.2 -0.0 -1.5
Alcohol intake frequency. 0.5 1.3 2.3 -1.2 -0.1 1.5 1.2
Comparative height size at age 10 0.1 0.5 1.7 1.3 0.0 0.2 -0.2
Number of full sisters 1.3 1.6 2.7 1.0 -1.7 -0.4 -1.5
Suffer from ‘nerves’ 5.9 9.2 11.0 -3.3 2.8 2.6 3.3
Overall health rating 2.1 4.6 7.4 2.4 -2.0 -1.0 -2.7
Chest pain or discomfort 1.2 1.7 2.2 -1.2 1.5 1.3 1.2
Had major operations 0.5 0.5 1.3 0.7 0.2 -0.6 1.1
Age at last live birth 3.1 4.5 8.5 -2.5 1.4 1.1 2.9
Family relationship satisfaction 2.1 2.6 4.4 -1.6 2.1 1.6 1.0
Leg pain on walking 0.7 0.9 1.6 0.8 -1.1 0.1 -1.3
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.4 -0.6 0.1 0.4 -0.5
Commuting to job workplace: Car/motor vehicle 0.9 1.0 2.3 0.9 -1.5 -0.9 -0.2
Illness, injury, bereavement, stress in last 2 years 0.5 0.6 1.1 -0.6 0.4 0.8 -1.1
Medication: Aspirin 0.2 0.3 0.6 -0.1 0.5 0.6 -0.8
Supplements: Vitamin C 1.1 1.3 2.7 1.6 -1.1 -0.1 -1.1
Knee pain experienced in last month 0.6 0.9 2.2 1.1 -0.5 0.3 -1.5
Hypertension (Self-reported) 4.9 13.7 20.4 3.2 -4.5 -2.2 -4.4
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 1.0 1.2 3.0 -1.2 0.2 1.7 -0.7
Illnesses of father: Heart disease 0.7 0.9 2.2 0.8 -0.6 -1.5 0.7
Illnesses of siblings: Diabetes 1.0 1.2 2.6 -0.0 0.9 1.6 -1.2
Smoking status: Previous 1.1 1.6 4.1 2.0 -0.9 -1.2 0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.9 2.0 2.6 -1.3 1.1 1.6 1.5
Whole body fat-free mass 1.8 10.3 17.3 4.2 -2.4 -1.9 -3.8
Leg fat-free mass (right) 2.9 15.5 23.6 4.5 -3.5 -2.4 -4.9
Arm fat percentage (left) 4.4 17.6 23.7 4.9 -4.9 -3.5 -3.3
Average weekly red wine intake 3.7 5.5 12.7 2.2 -2.0 -3.6 -0.5
Handedness (chirality/laterality): Left-handed 0.2 0.3 0.8 0.6 -0.2 -0.9 0.1
Mood swings 7.3 13.2 14.6 -3.6 3.8 3.6 3.4
Loneliness, isolation 0.6 0.8 2.8 -0.3 0.5 1.7 0.2
Long-standing illness, disability or infirmity 0.2 0.3 0.7 -0.1 0.1 0.8 0.8
Ever had bowel cancer screening 2.5 3.0 5.3 -1.4 2.1 0.3 2.3
Diabetes diagnosed by doctor 1.3 2.1 5.1 1.7 -0.6 -0.3 -2.2
Ever had stillbirth, spontaneous miscarriage or termination 1.7 1.9 3.7 1.2 -1.3 -0.7 -1.9
Friendships satisfaction 0.5 0.6 1.6 -1.3 0.6 0.8 -0.1
Qualifications: nursing, teaching 0.2 0.3 0.5 -0.7 0.3 -0.7 0.4
Commuting to job workplace: Walk 0.4 0.4 1.2 -0.4 1.1 0.3 0.3
Eye problems/disorders: Cataract 0.3 0.3 0.9 -0.9 0.1 -0.6 -0.3
Mouth/teeth dental problems: Mouth ulcers 1.2 2.0 3.0 -1.2 1.0 1.6 1.7
Medication for cholesterol 0.9 1.4 1.8 -1.3 1.3 0.5 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.8 1.0 2.3 -1.5 -0.2 0.8 0.9
Back pain experienced in last month 0.3 0.4 1.3 0.3 -1.1 0.3 0.2
Mineral and other dietary supplements 3.2 4.3 8.1 -2.8 1.6 2.4 0.8
Breast cancer (self-reported) 0.1 0.1 0.2 0.4 0.3 0.1 0.3
Asthma (self-reported) 4.3 8.5 14.9 2.6 -3.9 -3.0 -1.7
Osteoporosis (self-reported) 3.1 3.8 7.1 -2.1 1.8 0.8 2.7
Osteoarthritis (self-reported) 3.6 4.7 8.4 2.9 -2.5 -2.0 0.4
Medication: Aspirin 0.1 0.1 0.3 0.1 0.1 0.5 -0.5
Medication: Gliclazide 1.3 1.4 2.8 1.7 -1.0 -0.5 -1.2
Illnesses of father: None of the above (group 1) 2.4 2.9 4.7 -1.4 2.1 2.2 0.8
Smoking status: Current 5.8 9.2 16.0 1.8 -3.4 -2.4 -4.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.6 5.5 6.2 -2.1 2.5 2.3 2.5
Whole body water mass 1.9 11.0 18.7 4.3 -2.6 -2.1 -3.8
Leg predicted mass (right) 2.9 15.4 23.8 4.5 -3.5 -2.4 -4.9
Arm fat mass (left) 4.8 19.8 29.4 5.4 -4.7 -3.7 -3.8
Number of self-reported non-cancer illnesses 0.3 0.6 2.3 0.2 0.2 0.2 1.5
Average weekly champagne plus white wine intake 0.9 1.3 3.5 1.9 -0.9 -0.2 -0.9
Miserableness 15.0 26.0 31.2 -5.2 5.6 4.7 4.9
Guilty feelings 4.3 6.5 10.8 -2.3 3.0 0.9 3.3
Wears glasses or contact lenses 0.3 0.3 0.9 -0.5 0.4 -0.1 1.0
Ever taken oral contraceptive pill 0.2 0.2 0.4 0.1 0.6 0.7 -0.3
Hearing aid user 0.2 0.2 0.7 0.3 -0.2 0.8 -0.2
Mother’s age at death 2.7 3.4 8.2 -1.7 1.6 0.1 2.9
Financial situation satisfaction 0.8 1.0 2.6 -0.4 -1.1 -0.1 -1.6
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.2 -0.2 0.3 1.1 1.1
Commuting to job workplace: Public transport 2.6 3.1 6.1 -1.7 1.8 0.4 2.5
Eye problems/disorders: Glaucoma 0.5 0.6 1.3 1.0 -0.4 -1.1 -0.2
Medication: Blood pressure 4.8 9.1 12.2 2.9 -3.5 -2.0 -3.5
Pain type(s) experienced in last month: Hip pain 2.4 3.0 6.3 2.5 -1.5 -1.3 -1.3
Supplements: Fish oil (including cod liver oil) 5.1 6.6 10.0 3.2 -2.6 -2.8 -1.4
High cholesterol (Self-reported) 2.4 4.3 7.0 2.6 -2.1 -2.4 0.6
Medication: Bendroflumethiazide 8.5 12.9 16.2 3.6 -4.0 -2.8 -3.9
Medication: Paracetamol 3.5 5.4 10.0 -1.9 2.1 1.9 3.2
Medication: Lisinopril 1.2 1.5 2.4 1.1 -1.1 -1.0 -1.6
Medication: Atorvastatin 0.1 0.2 0.4 0.2 -0.6 0.5 0.2
Illnesses of father: High blood pressure 5.1 6.3 10.4 3.2 -2.1 -2.7 -1.7
Alcohol drinker status: Never 4.0 4.7 10.0 -1.2 3.2 1.9 2.0
Ever smoked 0.7 1.3 2.3 1.5 -1.0 -1.4 -0.1
Basal metabolic rate 2.3 12.7 21.2 4.6 -2.9 -2.3 -3.9
Leg fat percentage (left) 4.9 17.8 25.7 5.1 -5.0 -3.6 -2.7
Arm fat-free mass (left) 2.4 12.3 22.9 4.8 -2.8 -2.6 -3.5
Number of operations (self-reported) 2.1 3.2 4.6 2.1 -2.1 -1.9 0.4
Average weekly beer plus cider intake 6.0 8.7 11.9 -3.4 3.3 2.7 2.1
Irritability 13.7 23.1 30.1 -4.9 4.8 3.9 5.5
Risk taking 4.6 6.7 8.8 3.0 -2.6 -2.7 -2.0
Ever had prostate specific antigen (PSA) test 1.4 1.6 3.9 -0.3 2.0 1.3 0.8
Fractured/broken bones in last 5 years 1.1 1.5 2.3 -1.5 1.3 1.0 1.0
Age started oral contraceptive pill 3.0 3.8 5.9 -2.2 2.4 0.8 2.0
Diastolic blood pressure, automated reading 13.9 43.0 54.0 7.3 -7.1 -6.5 -5.1
Ever depressed for a whole week 2.5 3.1 4.6 -2.1 1.3 1.8 1.7
Unable to work because of sickness or disability 1.4 1.8 3.1 1.4 -1.8 -0.5 -1.4
Commuting to job workplace: Cycle 0.2 0.2 0.7 -0.0 -0.2 -0.3 -0.8
Myopia 0.4 0.6 1.0 -0.8 0.4 0.7 1.0
Vascular/heart problems diagnosed by doctor 3.7 10.0 14.9 -3.2 3.9 2.2 3.2
Cholesterol lowering medication 0.3 0.4 0.7 0.9 -0.4 -0.6 0.6
Medication: Omeprazole (e.g. Zanprol) 0.5 0.6 2.1 -0.0 0.6 1.4 -0.1
Pain experienced in last month 0.5 0.9 2.0 0.2 -0.9 -1.4 0.8
Supplements: Calcium 0.6 0.7 1.6 -0.4 0.7 0.8 1.3
Basal cell carcinoma (self-reported) 0.0 0.1 0.2 0.2 0.0 0.4 0.1
Heart attack/myocardial infarction (self-reported) 0.1 0.2 0.4 -0.1 -0.4 0.4 0.7
Deep venous thrombosis (DVT) (self-reported) 0.3 0.4 0.5 0.6 0.6 0.4 -0.7
Heart disease (siblings) 0.1 0.1 0.3 0.6 -0.2 0.0 0.3
Alcohol drinker status: Previous 0.1 0.1 0.3 0.2 -0.6 0.2 0.2
Pack years of smoking 0.8 1.1 3.1 -0.2 -1.1 0.1 -1.8
Impedance of whole body 7.6 38.5 51.6 -6.9 6.1 4.2 7.2
Leg fat mass (left) 5.4 21.1 31.1 5.6 -5.0 -3.8 -3.7
Arm predicted mass (left) 2.7 13.7 25.2 5.0 -3.1 -2.9 -3.4