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chr11:29,646,947-33,310,265

Best TWAS P=3.93e-13 · Best GWAS P=4.24e-17 conditioned to 3.08e-05

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Artery Aorta	RCN1	0.19	0.17	enet	13	0.15	1.9e-08	-4.9	5.3	9.8e-08	-0.02	0.07	0.93	TRUE
2	GTEx	Brain Cerebellum	HNRNPA3P9	0.20	0.03	enet	20	0.07	4.9e-03	-5.4	-5.4	8.5e-08	0.00	0.03	0.79	FALSE
3	GTEx	Heart Left Ventricle	MPPED2	0.13	0.01	lasso	5	-0.01	8.1e-01	5.1	6.4	1.8e-10	0.46	0.12	0.14	TRUE
4	GTEx	Heart Left Ventricle	HNRNPA3P9	0.09	0.08	lasso	2	0.05	8.2e-04	-5.4	-5.4	6.9e-08	-0.01	0.02	0.95	FALSE
5	GTEx	Skin Not Sun Exposed Suprapubic	RCN1	0.18	0.07	lasso	5	0.08	2.8e-05	-3.9	5.2	1.5e-07	-0.02	0.14	0.62	FALSE
6	GTEx	Thyroid	MPPED2	0.16	0.01	enet	13	0.07	2.3e-06	6.9	-5.2	2.0e-07	-0.66	0.12	0.84	FALSE
7	GTEx	Whole Blood	ARL14EP	0.07	0.05	lasso	2	0.05	3.3e-05	-6.0	6.0	1.6e-09	0.42	0.82	0.01	FALSE
8	ROSMAP	Brain Pre-frontal Cortex	MPPED2	0.25	0.29	lasso	7	0.29	4.4e-37	5.7	-5.5	3.9e-08	-0.50	1.00	0.00	FALSE
9	The Cancer Genome Atlas	Breast Invasive Carcinoma	C11orf46	0.05	0.05	lasso	5	0.06	6.2e-12	-5.9	6.5	1.0e-10	0.43	0.35	0.65	FALSE
10	The Cancer Genome Atlas	Colon Adenocarcinoma	C11orf46	0.12	0.08	blup	34	0.07	5.7e-05	6.9	7.3	3.9e-13	0.61	0.00	0.99	TRUE
11	The Cancer Genome Atlas	Colon Adenocarcinoma	CCDC73	0.14	0.14	lasso	4	0.12	2.3e-07	-5.6	-5.6	2.2e-08	0.03	0.01	0.99	TRUE
12	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	C11orf46	0.06	0.06	lasso	2	0.05	5.5e-06	-5.7	5.6	2.0e-08	0.41	0.45	0.54	FALSE
13	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	C11orf46	0.36	0.27	lasso	5	0.30	8.3e-34	-5.7	6.8	1.1e-11	0.48	0.51	0.49	FALSE
14	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	C11orf46	0.13	0.12	lasso	3	0.11	8.9e-07	-5.7	5.8	7.6e-09	0.42	0.38	0.61	FALSE
15	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	CCDC73	0.13	0.07	blup	82	0.07	9.9e-05	-5.6	-5.2	2.0e-07	0.04	0.03	0.95	FALSE
16	The Cancer Genome Atlas	Brain Lower Grade Glioma	CCDC73	0.11	0.09	lasso	3	0.08	2.5e-09	-5.6	-5.5	5.1e-08	0.03	0.01	0.99	FALSE
17	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	C11orf46	0.12	0.07	blup	34	0.07	4.4e-04	-5.7	7.2	7.2e-13	0.55	0.04	0.52	FALSE
18	The Cancer Genome Atlas	Lung Adenocarcinoma	C11orf46	0.09	0.11	lasso	4	0.10	1.2e-11	-5.8	6.4	2.0e-10	0.46	0.38	0.62	FALSE
19	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	C11orf46	0.05	0.02	lasso	2	0.02	9.9e-04	4.2	5.7	1.1e-08	0.47	0.02	0.72	FALSE
20	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	C11orf46	0.07	0.04	blup	34	0.07	2.5e-05	3.9	5.4	5.9e-08	0.49	0.06	0.85	FALSE
21	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	C11orf46	0.22	0.22	lasso	3	0.20	1.1e-08	-5.7	5.8	5.4e-09	0.41	0.42	0.58	FALSE
22	The Cancer Genome Atlas	Prostate Adenocarcinoma	C11orf46	0.09	0.07	lasso	2	0.06	2.4e-07	-5.7	5.8	9.0e-09	0.41	0.42	0.57	FALSE
23	The Cancer Genome Atlas	Stomach Adenocarcinoma	C11orf46	0.11	0.05	enet	7	0.09	3.4e-07	-5.9	6.2	5.4e-10	0.48	0.30	0.69	FALSE
24	The Cancer Genome Atlas	Thyroid Carcinoma	C11orf46	0.12	0.06	blup	34	0.10	1.4e-09	-5.7	5.6	1.7e-08	0.38	0.42	0.58	FALSE
25	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	MPPED2	0.20	-0.01	blup	147	0.05	2.0e-02	1.6	5.7	9.3e-09	0.67	0.03	0.09	FALSE