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chr11:16,343,081-19,345,331

Best TWAS P=5.12e-13 · Best GWAS P=1.62e-12 conditioned to 0.0271

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	SAAL1	0.15	0.17	enet	13	0.21	1.3e-24	-5.9	5.7	1.6e-08	0.53	0.98	0.02	FALSE
2	CommonMind	Brain Pre-frontal Cortex	TPH1	0.12	0.08	bslmm	478	0.08	8.0e-10	-6.6	-6.2	7.1e-10	-0.66	0.23	0.77	FALSE
3	GTEx	Adipose Subcutaneous	SERGEF	0.19	0.17	lasso	8	0.19	9.4e-16	-5.6	-6.2	6.0e-10	-0.66	0.48	0.52	FALSE
4	GTEx	Adipose Subcutaneous	SPTY2D1	0.18	0.14	lasso	5	0.14	6.7e-12	-6.4	6.1	8.9e-10	-0.04	0.05	0.95	FALSE
5	GTEx	Adipose Visceral Omentum	SERGEF	0.15	0.12	enet	9	0.11	1.9e-06	-6.5	-5.8	5.4e-09	-0.71	0.22	0.77	FALSE
6	GTEx	Artery Aorta	SAAL1	0.20	0.15	enet	15	0.21	1.1e-11	-5.0	5.5	4.0e-08	0.52	1.00	0.00	FALSE
7	GTEx	Artery Aorta	SPTY2D1	0.13	0.17	enet	10	0.16	2.5e-09	6.8	7.2	5.1e-13	-0.07	0.00	1.00	TRUE
8	GTEx	Brain Cerebellar Hemisphere	SAAL1	0.30	0.20	lasso	5	0.27	1.2e-07	-5.3	5.6	2.5e-08	0.55	0.75	0.22	FALSE
9	GTEx	Brain Cerebellum	SAAL1	0.26	0.23	lasso	9	0.26	3.6e-08	-5.9	6.4	1.7e-10	0.53	0.67	0.21	TRUE
10	GTEx	Brain Frontal Cortex BA9	SAAL1	0.21	0.05	enet	14	0.06	1.1e-02	-5.0	5.2	1.5e-07	0.47	0.15	0.10	FALSE
11	GTEx	Cells EBV-transformed lymphocytes	SAAL1	0.39	0.34	lasso	7	0.33	1.2e-11	-5.0	5.3	1.4e-07	0.47	1.00	0.00	FALSE
12	GTEx	Cells Transformed fibroblasts	SERGEF	0.22	0.15	enet	22	0.16	3.8e-12	-6.6	-5.3	8.7e-08	-0.64	0.23	0.77	FALSE
13	GTEx	Cells Transformed fibroblasts	SAAL1	0.22	0.19	enet	18	0.23	4.5e-17	-5.0	5.9	3.7e-09	0.49	1.00	0.00	FALSE
14	GTEx	Cells Transformed fibroblasts	SPTY2D1	0.31	0.27	lasso	6	0.26	2.5e-19	6.7	6.6	3.9e-11	-0.06	0.00	1.00	FALSE
15	GTEx	Cells Transformed fibroblasts	SPTY2D1-AS1	0.14	0.12	lasso	6	0.11	9.0e-09	6.7	6.3	2.4e-10	-0.06	0.00	1.00	FALSE
16	GTEx	Colon Transverse	SAAL1	0.15	0.05	lasso	5	0.08	1.9e-04	-5.0	5.3	9.1e-08	0.49	0.78	0.08	FALSE
17	GTEx	Esophagus Gastroesophageal Junction	SAAL1	0.17	0.14	enet	9	0.13	1.9e-05	-5.0	5.2	2.0e-07	0.44	0.77	0.05	FALSE
18	GTEx	Esophagus Mucosa	SERGEF	0.14	0.20	lasso	3	0.19	9.5e-13	-5.6	-5.9	3.2e-09	-0.69	0.58	0.42	FALSE
19	GTEx	Esophagus Mucosa	SAAL1	0.11	0.08	lasso	2	0.08	3.3e-06	-5.0	5.4	5.7e-08	0.45	0.98	0.01	FALSE
20	GTEx	Esophagus Muscularis	SAAL1	0.31	0.22	enet	20	0.24	2.2e-14	-5.0	5.7	1.2e-08	0.42	1.00	0.00	FALSE
21	GTEx	Heart Left Ventricle	SERGEF	0.19	0.02	enet	14	0.07	2.2e-04	-6.5	-5.4	8.2e-08	-0.47	0.10	0.58	FALSE
22	GTEx	Heart Left Ventricle	SAAL1	0.20	0.09	lasso	8	0.08	5.3e-05	-5.9	5.8	6.7e-09	0.48	0.88	0.08	FALSE
23	GTEx	Lung	SERGEF	0.10	0.08	enet	17	0.04	1.0e-03	-5.6	-5.2	2.4e-07	-0.68	0.43	0.55	FALSE
24	GTEx	Lung	OR7E14P	0.22	0.13	enet	28	0.26	3.4e-20	-3.1	-5.7	1.0e-08	-0.05	0.41	0.33	TRUE
25	GTEx	Muscle Skeletal	SERGEF	0.26	0.31	enet	11	0.35	9.7e-36	-6.5	-6.4	1.5e-10	-0.75	0.27	0.73	TRUE
26	GTEx	Muscle Skeletal	RP1-59M18.2	0.15	0.18	enet	8	0.20	2.4e-19	-5.6	-6.1	1.2e-09	-0.72	0.50	0.50	FALSE
27	GTEx	Pancreas	SAAL1	0.29	0.23	lasso	6	0.22	1.3e-09	-5.0	5.2	2.2e-07	0.48	0.99	0.01	FALSE
28	GTEx	Pituitary	SAAL1	0.22	0.12	lasso	4	0.10	2.2e-03	-5.0	5.5	5.1e-08	0.48	0.14	0.12	FALSE
29	GTEx	Skin Not Sun Exposed Suprapubic	SERGEF	0.24	0.15	lasso	12	0.16	5.9e-09	-5.7	-5.2	1.7e-07	-0.64	0.38	0.62	FALSE
30	GTEx	Skin Sun Exposed Lower leg	SERGEF	0.12	0.07	lasso	3	0.07	3.1e-06	-5.6	-5.6	1.9e-08	-0.72	0.09	0.91	FALSE
31	METSIM	Adipose	SAAL1	0.07	0.03	enet	28	0.06	8.2e-09	-5.0	6.2	5.9e-10	0.60	0.98	0.02	FALSE
32	METSIM	Adipose	SERGEF	0.09	0.10	lasso	4	0.10	5.1e-15	-5.6	-5.7	1.2e-08	-0.69	0.89	0.11	FALSE
33	NTR	Blood	SAAL1	0.02	0.01	lasso	3	0.01	2.2e-05	-5.9	5.9	3.8e-09	0.44	0.23	0.13	FALSE
34	ROSMAP	Brain Pre-frontal Cortex	SAAL1	0.15	0.17	lasso	7	0.17	5.3e-21	-5.2	5.5	4.5e-08	0.56	1.00	0.00	FALSE
35	The Cancer Genome Atlas	Breast Invasive Carcinoma	SAAL1	0.02	0.03	lasso	2	0.03	3.3e-07	-4.8	5.1	2.7e-07	0.47	0.77	0.22	FALSE
36	The Cancer Genome Atlas	Breast Invasive Carcinoma	SPTY2D1	0.03	0.02	lasso	3	0.03	1.4e-06	6.7	5.5	3.6e-08	-0.06	0.01	0.99	FALSE
37	The Cancer Genome Atlas	Colon Adenocarcinoma	SPTY2D1	0.05	0.05	lasso	4	0.05	5.2e-04	6.7	5.5	3.8e-08	-0.05	0.01	0.96	FALSE
38	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SAAL1	0.07	0.07	enet	9	0.07	9.4e-09	-4.8	5.4	5.6e-08	0.47	0.83	0.17	FALSE
39	The Cancer Genome Atlas	Brain Lower Grade Glioma	SAAL1	0.12	0.24	enet	13	0.24	1.0e-26	-5.0	5.7	1.6e-08	0.54	0.95	0.05	FALSE
40	The Cancer Genome Atlas	Brain Lower Grade Glioma	SERGEF	0.07	0.09	lasso	2	0.08	9.6e-10	-5.3	5.2	1.8e-07	0.57	0.99	0.01	FALSE
41	The Cancer Genome Atlas	Lung Adenocarcinoma	SERGEF	0.04	0.00	blup	130	0.01	4.1e-02	-6.5	-5.5	4.8e-08	-0.70	0.03	0.68	FALSE
42	The Cancer Genome Atlas	Lung Adenocarcinoma	SPTY2D1	0.06	0.07	lasso	2	0.06	1.5e-07	6.8	6.7	1.8e-11	-0.06	0.00	1.00	FALSE
43	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SAAL1	0.02	0.01	blup	52	0.01	3.7e-02	-5.6	5.3	1.0e-07	0.49	0.05	0.10	FALSE
44	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SERGEF	0.02	0.00	blup	130	0.01	8.6e-03	-6.6	-5.9	2.9e-09	-0.77	0.07	0.52	FALSE
45	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	SPTY2D1	0.03	0.00	blup	43	0.01	2.0e-02	6.8	7.0	3.5e-12	-0.06	0.00	0.99	FALSE
46	The Cancer Genome Atlas	Prostate Adenocarcinoma	SAAL1	0.04	0.06	lasso	3	0.04	1.0e-04	-5.0	5.2	2.5e-07	0.45	0.90	0.09	FALSE
47	The Cancer Genome Atlas	Prostate Adenocarcinoma	SERGEF	0.06	0.00	blup	130	0.02	9.2e-03	-5.6	-5.4	7.3e-08	-0.53	0.18	0.38	FALSE
48	The Cancer Genome Atlas	Prostate Adenocarcinoma	SPTY2D1	0.14	0.20	lasso	3	0.20	4.4e-21	6.8	6.8	1.5e-11	-0.06	0.00	1.00	FALSE
49	The Cancer Genome Atlas	Soft Tissue Sarcoma	SAAL1	0.04	0.00	enet	8	0.03	8.0e-03	-5.9	5.5	4.2e-08	0.45	0.05	0.17	FALSE
50	The Cancer Genome Atlas	Thyroid Carcinoma	SPTY2D1	0.10	0.09	lasso	3	0.09	3.2e-09	6.7	6.5	7.0e-11	-0.06	0.01	0.99	FALSE