Best TWAS P=1.18e-11 · Best GWAS P=6.22e-28 conditioned to 2.66e-14
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | MTMR11 | 0.08 | 0.04 | lasso | 4 | 0.05 | 3.5e-05 | -5.14 | -5.3 | 1.4e-07 | -0.37 | 0.78 | 0.03 | FALSE |
| 2 | GTEx | Artery Aorta | CTSK | 0.23 | 0.00 | enet | 24 | 0.02 | 3.9e-02 | 3.11 | -6.2 | 6.9e-10 | 0.02 | 0.10 | 0.06 | TRUE |
| 3 | GTEx | Artery Tibial | HIST2H2AA3 | 0.22 | 0.02 | enet | 20 | 0.12 | 1.8e-09 | 9.13 | 6.8 | 1.2e-11 | 0.70 | 0.00 | 1.00 | TRUE |
| 4 | GTEx | Artery Tibial | RP11-196G18.22 | 0.25 | 0.05 | lasso | 5 | 0.07 | 1.8e-06 | 4.90 | 6.6 | 3.8e-11 | 0.78 | 0.01 | 0.98 | FALSE |
| 5 | GTEx | Artery Tibial | RP11-196G18.24 | 0.31 | 0.08 | enet | 26 | 0.10 | 6.1e-08 | 9.13 | 6.2 | 4.6e-10 | 0.72 | 0.00 | 0.99 | FALSE |
| 6 | GTEx | Lung | MTMR11 | 0.08 | 0.04 | lasso | 8 | 0.03 | 3.0e-03 | -5.14 | -5.2 | 1.5e-07 | -0.29 | 0.19 | 0.11 | FALSE |
| 7 | GTEx | Nerve Tibial | SEMA6C | 0.15 | 0.01 | enet | 15 | 0.02 | 1.4e-02 | -2.55 | -5.5 | 4.9e-08 | -0.04 | 0.34 | 0.36 | TRUE |
| 8 | GTEx | Skin Sun Exposed Lower leg | SV2A | 0.07 | 0.00 | enet | 15 | 0.02 | 6.0e-03 | -0.83 | -5.6 | 2.5e-08 | -0.16 | 0.07 | 0.12 | TRUE |
| 9 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ENSA | 0.02 | 0.01 | enet | 3 | 0.01 | 2.5e-02 | 3.62 | -5.6 | 1.8e-08 | 0.08 | 0.00 | 0.78 | TRUE |
| 10 | The Cancer Genome Atlas | Prostate Adenocarcinoma | MTMR11 | 0.02 | 0.02 | lasso | 3 | 0.02 | 3.7e-03 | -5.14 | -5.2 | 2.3e-07 | -0.30 | 0.00 | 0.85 | FALSE |