Hub : Genes

ENSA

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 METSIM Adipose 0.0509 0.0222 0.00051 0.001 0.016 0.000 0.016 0.003 0.2200 1.6e-03 2.6e-01 1.5e-03 9.4e-02
2 YFS Blood 0.0227 0.0092 0.00012 0.005 0.013 0.012 0.012 0.012 0.0049 2.4e-05 7.2e-05 4.1e-05 5.7e-05
3 TCGA Colon Adenocarcinoma 0.1000 0.0610 0.00400 0.042 0.030 0.030 NA 0.037 0.0019 7.1e-03 7.3e-03 NA 3.1e-03
4 TCGA Prostate Adenocarcinoma 0.0206 0.0149 0.00950 0.009 0.006 0.010 NA 0.007 0.0390 7.1e-02 2.5e-02 NA 5.0e-02

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4
Bipolar Disorder (2018) 1.2 1.9 5.9 2.4 -0.4 0.9 -0.7
Bipolar Disorder or Schizophrenia 2.3 5.6 12.9 3.6 -0.3 2.8 -1.2
Depressed Affect (Nagel 2018) 0.6 1.2 2.5 1.6 0.6 1.1 -0.9
Depression (Nagel 2018) 2.1 3.1 5.2 2.2 -0.3 2.3 -1.5
Intelligence (Savage-Jansen 2018) 0.5 1.7 2.1 -1.4 1.2 -1.1 1.4
Neuroticism (Nagel 2018) 0.8 2.0 3.5 1.6 0.6 1.9 -1.2
Schizophrenia (2018) 2.0 4.1 8.3 2.6 -0.1 2.9 -0.9
Schizophrenia vs Biploar Disorder 0.7 0.9 2.4 -0.8 0.2 1.6 -0.7
Worry (Nagel 2018) 0.2 0.5 0.9 0.9 0.1 1.0 -0.6
Alzheimer’s Disease (in mother) 2.3 2.7 5.6 -0.8 0.4 -2.1 2.4
Alzheimer’s Disease (in father) 0.5 0.6 0.8 -0.8 -0.3 -0.9 0.9
Alzheimer’s Disease (including proxy) 1.2 1.8 4.5 -0.5 -0.2 -1.5 2.1
Crohns Disease (2017) 1.0 2.2 4.5 -1.3 1.2 -1.1 2.1
Irritable Bowel Disease (IBD) 1.2 2.9 6.0 -1.1 0.1 -2.1 2.5
Ulcerative Colitis (UC) 1.0 2.0 4.6 -0.2 -0.5 -2.1 1.7
Major Depression (MDD) 0.2 0.3 0.7 0.3 0.4 0.8 -0.3
Reaction Time 0.8 1.5 2.0 1.4 -1.2 -1.2 -0.9
Verbal and Numeric Reasoning (VNR) 0.3 0.6 1.8 -0.2 1.3 -0.4 0.7
Breast Cancer 1.4 3.3 7.8 0.4 -2.8 1.5 -1.7
Ovarian Cancer 2.4 3.2 6.3 1.5 2.5 0.3 2.0
Prostate Cancer 5.8 8.1 26.0 -1.2 5.1 -2.2 -0.5
Age at First Birth 0.1 0.1 0.2 0.1 -0.3 0.4 -0.3
Bipolar Disorder (2011) 1.4 1.4 5.2 2.3 0.5 0.0 -0.0
Body Mass Index (BMI) (2010) 0.9 1.2 2.2 -0.7 -0.6 -1.4 1.5
Coronary Artery Disease (CAD) 4.9 5.8 20.4 0.3 1.7 -0.1 4.5
Crohns Disease (2012) 0.9 1.4 2.5 -0.7 0.7 -1.6 1.4
Mean Putamen Volume 1.5 1.7 3.8 -1.1 1.3 -0.5 1.9
Fasting Glucose 1.2 1.4 2.8 1.6 -0.5 1.7 0.1
HbA1C 3.1 3.5 10.1 1.1 1.3 3.2 -0.9
HDL Cholesterol 0.7 1.1 3.9 -0.1 -0.3 -2.0 0.8
LDL Cholesterol 1.3 2.1 4.4 1.3 0.4 2.1 -1.4
Lupus 1.4 2.1 5.1 1.6 0.3 2.3 -0.8
Neuroticism (2016) 1.5 2.2 6.1 1.1 -0.8 2.5 -1.0
Primary Biliary Cirrhosis 2.3 3.3 7.4 0.4 -1.5 1.8 -2.7
Rheumatoid Arthritis 2.1 2.9 5.4 -1.9 2.3 0.3 1.6
Schizophrenia (2014) 3.0 6.6 11.6 3.3 -0.7 3.4 -1.9
Triglycerides 0.2 0.4 1.3 1.1 0.5 -0.4 0.1
Type 2 Diabetes (T2D) (2012) 0.2 0.2 0.6 0.1 0.2 0.4 -0.8
Ulcerative Colitis 1.1 1.6 3.6 0.8 -1.9 -1.4 0.5
Blood Eosinophil Count 5.4 41.8 82.6 -5.5 -7.1 -2.0 -9.1
Blood Platelet Count 2.2 25.4 88.2 1.0 -3.1 1.6 -9.4
Blood Red Count 0.6 6.0 14.2 -2.7 -0.1 -3.8 1.7
Blood White Count 2.6 18.9 48.4 -7.0 -3.2 -2.2 -3.5
Heel T-Score 1.8 14.6 30.6 4.6 -0.5 5.5 -2.6
BMI 0.1 0.7 1.1 1.0 -0.6 0.4 1.0
Height 1.5 28.7 46.6 -6.8 -2.0 4.9 -6.3
Waist Hip Ratio (WHR) 1.3 5.8 15.6 1.4 4.0 -2.2 0.7
Systolic Blood Pressure 1.0 5.1 16.6 1.5 4.1 -0.9 1.0
Smoking Status 0.8 2.0 4.0 0.5 0.5 1.9 -2.0
Allergy or Eczema 2.4 6.2 15.8 0.1 -0.7 -2.9 4.0
Cardiovascular Disease 1.6 5.3 10.2 2.3 3.2 2.3 -0.7
Hypothyroidism (self reported) 1.0 2.3 5.0 0.6 1.2 1.5 2.2
Respiratory disease 0.5 1.1 2.4 1.6 0.0 0.7 1.2
Type 2 Diabetes (T2D) (2018) 1.1 2.1 3.8 1.0 1.9 -0.6 1.8
Lung FEV1/FVC ratio 2.4 12.1 30.7 2.2 1.0 -3.4 5.5
Lung FVC 11.8 60.1 89.5 8.1 -5.3 7.5 -9.5
Neuroticism 0.6 1.4 3.2 1.0 0.5 1.8 -1.0
Chronotype (morning person) 4.7 10.9 16.7 -4.1 -3.1 -3.9 1.3
Hair Pigment 0.1 1.9 3.8 -1.9 -0.1 0.4 -1.9
Tanning 0.9 10.9 27.8 -0.1 -3.1 2.5 -5.3
Hand grip strength (left) 0.9 2.2 4.0 1.1 -0.8 1.8 -2.0
Number of treatments/medications taken 1.8 3.3 4.8 2.2 2.0 0.2 2.0
Average weekly spirits intake 0.6 0.7 1.5 -1.2 -0.9 0.6 -0.4
Sensitivity / hurt feelings 0.5 0.8 2.0 0.9 0.6 1.4 0.2
Frequency of depressed mood in last 2 weeks 1.2 1.6 3.0 1.7 0.6 1.6 -0.8
Hearing difficulty/problems: Yes 0.5 0.8 1.8 0.1 1.3 -1.1 0.4
Relative age of first facial hair 3.3 6.7 18.0 -4.2 -0.1 -2.2 2.0
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 1.2 0.4 -1.1 0.2 -0.0
Ever used hormone-replacement therapy (HRT) 1.0 1.3 2.6 1.6 1.4 -0.6 -0.3
Ever had hysterectomy (womb removed) 0.5 0.6 1.0 -0.2 -1.0 -1.0 -0.5
Systolic blood pressure, automated reading 1.3 3.9 9.0 1.0 3.0 -0.9 2.1
Eye problems/disorders: Diabetes related eye disease 1.2 1.3 3.1 1.8 -0.4 0.2 1.3
Angina 3.8 4.9 10.3 -0.4 3.2 0.3 3.0
Medication for hormone replacement therapy 1.6 1.8 6.0 2.5 -0.3 0.8 -0.7
Vitamin and mineral supplements 1.0 1.4 3.1 -0.4 -1.2 -1.0 -1.8
Supplements: Zinc 3.1 3.4 7.1 2.6 -0.1 2.7 -0.1
Medication: Co-codamol 1.4 1.6 3.8 -0.3 0.6 -1.9 1.5
Medication: Metformin 0.6 0.8 1.8 0.5 1.4 0.2 1.1
Diabetes (father) 0.4 0.5 1.2 0.8 -0.1 1.1 0.5
Diabetes (mother) 1.9 2.4 5.0 2.0 2.2 0.6 -0.3
Severe depression (siblings) 0.5 0.6 1.8 0.3 -1.4 -0.7 -0.1
Pack years adult smoking proportion 0.8 1.2 3.0 -1.2 -0.5 -0.2 -1.7
Impedance of leg (right) 4.5 21.7 44.8 -2.0 4.8 -3.9 6.7
Leg fat-free mass (left) 1.7 9.1 16.6 -0.9 -2.2 3.7 -4.1
Trunk fat percentage 1.8 7.3 25.2 -0.4 1.9 -0.5 5.0
Hand grip strength (right) 0.6 1.6 2.9 1.2 -0.5 1.7 -1.3
Townsend deprivation index at recruitment 0.5 0.6 2.0 -0.2 1.4 -0.3 0.6
Current tobacco smoking 0.4 0.6 2.2 -0.4 1.5 0.1 -0.0
Average weekly fortified wine intake 1.4 1.6 3.5 -0.2 -0.7 1.6 -1.9
Maternal smoking around birth 0.8 1.2 2.5 0.4 -0.9 1.6 -1.2
Fed-up feelings 0.2 0.3 0.8 0.3 0.9 0.1 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.2 0.2 0.5 -0.4 0.4 -0.7 0.2
Relative age voice broke 5.1 7.8 13.9 -3.6 0.7 -3.7 2.1
Taking other prescription medications 0.6 0.9 1.7 0.6 1.2 0.2 1.3
Age when periods started (menarche) 3.4 8.1 26.9 -5.2 -1.9 -0.7 -1.2
Bilateral oophorectomy (both ovaries removed) 0.2 0.2 0.4 -0.3 0.0 0.6 -0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.5 1.1 1.7 0.8 1.3 -0.5 1.2
Tinnitus: Yes, but not now, but have in the past 2.0 2.1 4.8 1.1 -2.2 0.6 -1.4
Qualifications: CSEs or equivalent 3.0 3.9 6.6 -1.6 0.8 -2.4 2.6
Serious illness, injury or assault to yourself 1.5 1.8 4.5 -0.9 1.0 -1.0 2.1
High blood pressure 1.5 4.1 8.6 2.2 2.9 1.3 -1.1
Hayfever, allergic rhinitis or eczema 1.0 2.3 5.4 0.3 -0.7 -1.7 2.3
Multivitamins +/- minerals 1.2 1.6 3.2 -0.8 1.8 -0.1 1.5
Stomach or abdominal pain in last month 1.3 1.6 3.4 1.5 -1.9 0.7 0.1
Supplements: Glucosamine 1.6 2.1 5.1 1.1 1.3 0.8 2.3
Diverticular disease/diverticulitis (self-reported) 0.7 0.8 1.8 0.6 -0.2 -1.0 1.4
Medication: Atenolol 0.5 0.7 2.0 -0.4 0.6 -1.4 0.3
Medication: Levothyroxine sodium 1.2 2.1 5.7 0.0 1.3 0.9 2.4
Sitting height 2.3 16.6 31.7 -4.9 -2.8 1.6 -5.6
Chronic bronchitis/emphysema (father) 0.9 1.0 2.7 -1.1 -0.1 -1.6 -0.4
High blood pressure (mother) 1.1 1.5 3.1 1.5 1.8 0.4 -0.8
Body mass index (BMI) 0.2 0.8 1.9 1.4 -0.1 1.0 0.2
Impedance of leg (left) 3.7 17.8 34.9 -1.6 4.0 -4.2 5.9
Leg predicted mass (left) 1.8 9.3 16.8 -0.9 -2.2 3.8 -4.1
Trunk fat mass 0.6 2.4 8.0 -0.6 1.1 0.5 2.8
Waist circumference 0.2 0.6 1.0 0.8 1.0 0.7 0.3
Number of incorrect matches in round 0.4 0.7 1.4 1.2 -0.8 -0.6 -0.4
Past tobacco smoking 0.1 0.2 0.4 -0.7 0.4 -0.2 0.4
Alcohol usually taken with meals 0.6 0.9 2.6 -0.6 -1.6 -0.0 -0.9
Nervous feelings 0.2 0.3 0.8 -0.4 0.6 -0.9 -0.2
Frequency of tenseness / restlessness in last 2 weeks 1.0 1.5 3.6 -0.1 -0.1 1.9 -1.6
Hearing difficulty/problems with background noise 0.3 0.4 0.7 -0.0 0.8 -0.8 0.5
Hair/balding pattern: Pattern 2 0.9 1.2 3.9 0.0 -0.8 2.0 -0.5
Had menopause 0.4 0.5 1.1 0.3 0.8 1.0 0.2
Had other major operations 2.5 3.1 6.3 0.9 -0.9 2.1 -2.5
Forced vital capacity (FVC) 7.4 28.6 54.0 3.1 -2.7 6.6 -7.3
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.5 1.1 0.5 0.9 1.1 0.1
Ever unenthusiastic/disinterested for a whole week 1.2 1.4 3.2 1.5 -0.6 0.3 -1.8
Qualifications: None of the above 0.4 1.0 2.8 1.7 0.9 0.4 -0.0
Financial difficulties in last 2 years 0.2 0.3 0.9 0.4 -0.1 -0.1 -0.9
Mouth/teeth dental problems 0.4 0.7 1.7 -0.7 0.3 -0.6 1.3
Heart attack 0.9 1.1 2.0 1.4 1.1 -0.5 0.9
Allergy 0.6 1.3 4.9 -0.3 0.4 0.3 -2.2
Pain all over the body in last month 0.5 0.5 2.1 -1.4 0.1 0.0 0.2
Diabetes (self-reported) 0.6 1.0 2.3 0.3 0.8 -0.9 1.5
Hayfever/allergic rhinitis (self-reported) 0.5 0.7 2.0 0.3 0.1 -1.4 0.9
Medication: Ramipril 1.1 1.4 2.2 1.5 1.2 -0.0 1.4
Medication: Simvastatin 0.2 0.4 1.3 1.2 0.3 0.1 0.0
Fluid intelligence score 0.1 0.2 0.3 -0.3 0.4 0.5 -0.5
Illnesses of siblings 1.3 1.8 4.2 -1.5 -2.0 -1.0 -0.2
Neuroticism score 0.3 0.6 1.7 0.1 0.1 0.7 -1.3
Weight 0.4 2.1 5.6 -0.8 -0.5 2.4 -1.4
Impedance of arm (right) 3.7 17.3 44.9 -3.6 3.0 -1.6 6.7
Arm fat percentage (right) 1.0 4.1 14.1 -0.3 1.4 0.4 3.8
Trunk fat-free mass 2.7 15.5 39.6 -0.9 -2.4 4.0 -6.3
Hip circumference 0.5 2.2 6.2 -0.7 -1.4 2.5 0.1
Time employed in main current job 0.4 0.5 1.1 -0.6 -1.0 -0.6 -0.4
Alcohol intake versus 10 years previously 1.4 2.1 5.7 0.9 2.4 1.1 0.8
Father’s age at death 1.1 1.5 2.3 1.3 -0.1 1.5 -1.4
Worrier / anxious feelings 0.2 0.3 0.9 -0.6 -1.0 0.1 -0.1
Frequency of tiredness / lethargy in last 2 weeks 1.5 2.4 5.2 1.9 0.6 2.3 -0.6
Falls in the last year 0.3 0.4 0.9 -1.0 -0.1 -0.1 0.9
Hair/balding pattern: Pattern 3 0.8 1.1 3.3 1.8 -1.0 -0.4 -0.1
Number of live births 1.0 1.3 2.9 -0.3 -1.7 -1.5 -0.3
Forced expiratory volume in 1-second (FEV1) 4.6 15.4 23.8 3.2 -2.2 4.9 -4.8
Pulse rate 0.6 1.1 3.3 0.6 -1.8 0.4 -0.8
Happiness 1.5 1.8 5.7 -0.0 -0.5 1.1 -2.4
Noisy workplace 1.1 1.3 3.7 -0.1 0.4 -1.9 1.2
Qualifications: A levels/AS levels or equivalent 0.2 0.4 0.8 0.3 0.6 0.6 -0.9
Serious illness, injury or assault of a close relative in last 2 years 0.6 0.7 1.4 -0.3 1.1 1.2 0.1
Mouth/teeth dental problems: Dentures 1.4 2.3 6.7 0.9 2.6 -1.0 0.9
Asthma 0.8 1.6 4.8 1.1 0.2 2.2 0.5
Medication: Ibuprofen (e.g. Nurofen) 1.0 1.2 2.8 1.7 -0.3 1.2 0.6
Medication: Cholesterol lowering 0.8 1.2 2.0 1.0 1.3 0.1 1.4
Depression (self-reported) 1.7 2.1 4.1 1.2 1.2 2.0 -1.1
Medication: Lansoprazole 2.1 2.4 3.9 1.7 2.0 -0.7 1.5
Prospective memory result 1.8 2.2 5.5 -0.6 -1.5 -2.3 1.0
Lung cancer (father) 2.6 3.0 6.0 -1.2 0.8 -2.5 2.0
Illnesses of mother 2.5 3.1 10.4 -1.1 -3.2 -0.5 -0.5
Forced expiratory volume in 1-second (FEV1), Best measure 5.1 16.3 25.7 2.6 -3.7 4.3 -5.1
Pulse wave Arterial Stiffness index 0.4 0.4 1.4 1.2 0.3 0.5 -0.1
Impedance of arm (left) 3.4 15.7 44.9 -2.6 2.9 -1.7 6.7
Arm fat mass (right) 0.2 1.0 1.9 -0.4 0.5 1.3 1.4
Trunk predicted mass 2.7 15.3 39.1 -0.9 -2.3 4.0 -6.2
Standing height 1.1 10.7 21.0 -4.6 -1.0 2.9 -3.5
Length of working week for main job 0.7 0.8 1.9 -1.0 0.0 -1.4 -0.3
Exposure to tobacco smoke at home 0.3 0.3 1.0 1.0 -0.1 0.1 -0.6
Breastfed as a baby 0.3 0.4 0.6 0.8 0.0 0.7 0.7
Tense / ‘highly strung’ 1.4 2.3 5.2 1.2 0.1 1.7 -2.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.9 1.4 2.7 1.5 1.6 0.9 0.2
Hair/balding pattern: Pattern 4 0.3 0.7 2.8 -0.0 1.7 0.1 -0.5
Birth weight of first child 2.2 4.1 10.6 -1.0 -1.4 1.6 -3.2
Peak expiratory flow (PEF) 1.1 2.6 3.4 1.8 -1.4 1.6 -1.5
Pulse wave reflection index 0.2 0.3 0.4 0.4 0.6 0.7 -0.2
Ever highly irritable/argumentative for 2 days 0.9 1.1 3.6 1.9 0.0 -0.0 -0.8
Loud music exposure frequency 1.4 1.6 2.6 1.6 1.0 -0.4 1.6
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.8 0.7 -0.4 0.9 -0.1
Mouth/teeth dental problems: Bleeding gums 0.9 1.1 4.3 0.1 -2.1 -0.3 0.3
Blood clot in the leg (DVT) 0.3 0.4 1.3 0.6 -0.0 1.2 -0.1
Medication: Paracetamol 0.5 0.9 2.8 1.7 -0.6 0.6 -0.1
Headache pain in last month 2.2 3.7 11.4 3.4 -0.0 1.7 -0.7
Medication for cholesterol, blood pressure or diabetes 0.4 0.7 1.1 -0.6 -0.9 0.7 -1.0
Glaucoma (self-reported) 1.2 1.5 4.5 -0.3 0.9 -0.6 2.1
Gout (self-reported) 0.4 0.6 1.7 0.6 1.3 0.5 -0.2
Hypothyroidism/myxoedema (self-reported) 1.4 2.7 7.0 1.0 1.4 0.9 2.6
Medication: Amlodipine 0.4 0.6 1.8 0.3 1.3 -0.2 0.6
Medication: Ventolin 100micrograms inhaler 0.3 0.4 1.0 0.6 -0.5 1.0 -0.2
Birth weight 2.8 6.0 10.0 -2.9 -1.8 -1.6 -3.2
Chronic bronchitis/emphysema (mother) 0.3 0.3 0.9 0.1 0.2 1.0 0.6
High blood pressure (siblings) 1.0 1.5 2.3 -0.0 1.5 1.3 -1.4
Forced vital capacity (FVC), Best measure 8.4 30.7 58.7 2.2 -4.7 6.1 -7.7
Body fat percentage 1.9 7.3 23.7 -0.3 2.2 -0.8 4.9
Leg fat percentage (right) 1.3 4.7 13.0 0.3 2.2 -0.9 3.6
Arm fat-free mass (right) 1.8 9.0 24.9 0.3 -1.6 2.9 -5.0
Exposure to tobacco smoke outside home 1.0 1.3 2.5 0.5 1.5 -0.4 1.6
Comparative body size at age 10 0.2 0.6 1.1 1.0 -0.7 -0.8 -0.3
Number of full brothers 0.3 0.3 0.7 0.2 0.8 -0.0 0.8
Worry too long after embarrassment 1.2 2.1 6.4 1.1 -0.7 0.6 -2.5
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 2.0 1.2 -0.3 1.4 -1.4
Wheeze or whistling in the chest in last year 0.9 1.6 3.3 0.9 1.3 1.8 -0.8
Number of children fathered 0.4 0.5 1.8 0.3 -1.3 0.2 0.0
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.9 0.6 -1.0 -0.5 -0.1
Age at first live birth 0.4 0.7 1.5 -0.9 -0.1 1.2 0.6
Pulse wave peak to peak time 0.6 0.7 2.5 -1.6 -0.4 -0.3 -0.4
Health satisfaction 0.9 1.2 3.0 1.7 0.4 0.8 0.8
Shortness of breath walking on level ground 1.3 1.5 4.2 -0.0 2.1 -0.3 1.3
Qualifications: College or University degree 1.1 3.4 8.4 1.1 0.2 2.9 -1.9
Eye problems/disorders: None of the above 1.4 1.6 4.4 -1.1 -0.9 0.2 -2.1
Mouth/teeth dental problems: Loose teeth 0.4 0.5 1.0 1.0 0.4 0.9 0.1
Emphysema/chronic bronchitis 0.3 0.3 0.6 -0.8 0.3 0.4 -0.6
Medication for pain relief, constipation, heartburn 1.2 2.0 3.9 -2.0 -1.1 -0.8 -1.5
Neck or shoulder pain in last month 1.9 2.6 5.6 2.4 0.5 2.0 -0.7
Medication: Blood pressure 0.7 1.2 2.3 -0.5 1.0 -1.5 1.1
Angina (self-reported) 3.6 4.7 9.5 -0.0 3.1 0.5 3.0
Migraine (self-reported) 1.0 1.2 2.2 1.5 -1.0 0.6 -1.1
Medication: Ibuprofen 1.2 1.4 2.8 1.7 -0.2 1.3 1.0
Medication: Allopurinol 0.4 0.5 1.6 0.7 1.3 0.2 -0.3
Medication: Omeprazole 2.6 3.1 5.5 -1.0 1.8 -1.7 2.4
Medication: Seretide 50 evohaler 0.3 0.3 0.8 -0.4 -0.2 0.9 0.6
Mean time to correctly identify matches 0.6 1.1 2.8 1.7 -0.8 -0.8 -0.6
Heart disease (mother) 0.6 0.8 1.1 0.7 0.9 0.8 -1.0
Reproduciblity of spirometry measurement using ERS/ATS criteria 2.3 2.7 4.5 1.5 0.2 -2.1 2.1
Whole body fat mass 0.4 1.8 5.3 -0.4 1.2 0.6 2.3
Leg fat mass (right) 0.3 1.1 2.9 -0.3 1.2 0.3 1.7
Arm predicted mass (right) 2.0 10.4 27.7 0.5 -2.1 3.0 -5.3
Pulse rate, automated reading 1.5 4.9 14.6 1.0 -3.8 -1.3 -1.5
Alcohol intake frequency. 0.1 0.2 0.4 0.6 -0.5 -0.3 -0.3
Comparative height size at age 10 0.6 3.3 8.9 -0.6 2.0 3.0 -0.1
Number of full sisters 1.2 1.4 2.4 -1.5 -0.6 -1.6 0.9
Suffer from ‘nerves’ 0.3 0.4 0.9 -0.3 0.8 0.9 0.2
Overall health rating 1.6 3.5 6.3 1.8 2.5 1.4 1.5
Chest pain or discomfort 0.4 0.5 1.4 0.1 0.7 1.2 0.4
Had major operations 0.7 0.8 2.6 1.6 -0.6 0.3 -0.3
Age at last live birth 0.6 0.8 1.1 -1.0 -1.1 1.0 -0.1
Family relationship satisfaction 1.3 1.6 5.9 0.6 -0.2 0.5 -2.4
Leg pain on walking 1.1 1.3 2.2 -0.4 1.5 -0.9 1.5
Qualifications: NVQ or HND or HNC or equivalent 1.7 2.1 5.8 -1.4 0.5 -2.4 0.7
Commuting to job workplace: Car/motor vehicle 3.5 4.0 10.8 -0.1 1.2 -2.0 3.3
Illness, injury, bereavement, stress in last 2 years 1.7 2.0 4.5 1.3 -1.4 -0.2 -2.1
Medication: Aspirin 0.8 1.0 1.9 -0.2 0.8 -1.2 1.4
Supplements: Vitamin C 0.8 1.0 2.4 0.7 -0.3 1.6 0.9
Knee pain experienced in last month 0.6 1.0 2.5 0.0 1.2 0.2 1.6
Hypertension (Self-reported) 1.4 3.9 7.1 2.3 2.7 1.4 -1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.2 2.6 5.8 0.7 2.4 -0.8 1.9
Illnesses of father: Heart disease 0.4 0.5 1.5 -0.2 1.2 0.5 0.6
Illnesses of siblings: Diabetes 0.8 1.0 2.3 -0.3 1.2 0.2 1.5
Smoking status: Previous 0.1 0.2 0.6 0.3 -0.4 0.7 -0.2
Forced expiratory volume in 1-second (FEV1), predicted 0.3 0.6 1.5 -1.2 0.0 1.0 -0.2
Whole body fat-free mass 2.4 13.5 31.4 -0.7 -2.6 3.9 -5.6
Leg fat-free mass (right) 2.3 12.2 25.1 -0.8 -2.8 3.9 -5.0
Arm fat percentage (left) 1.0 4.0 14.0 0.2 1.4 0.3 3.7
Average weekly red wine intake 0.3 0.5 1.0 -1.0 -0.1 0.8 0.6
Handedness (chirality/laterality): Left-handed 0.3 0.3 0.9 -0.5 0.5 0.1 1.0
Mood swings 0.7 1.2 2.9 0.5 -0.6 1.1 -1.7
Loneliness, isolation 0.6 0.8 2.9 -0.6 1.7 -0.0 0.1
Long-standing illness, disability or infirmity 1.4 2.2 6.1 -0.4 1.5 0.2 2.5
Ever had bowel cancer screening 0.4 0.4 1.3 0.1 -1.2 -0.0 0.5
Diabetes diagnosed by doctor 0.4 0.7 2.1 0.4 0.5 -0.5 1.4
Ever had stillbirth, spontaneous miscarriage or termination 0.3 0.3 0.6 -0.8 -0.4 -0.4 -0.6
Friendships satisfaction 1.4 1.8 5.9 -1.0 -0.4 0.2 -2.4
Qualifications: nursing, teaching 0.2 0.3 0.4 -0.6 -0.6 0.6 -0.3
Commuting to job workplace: Walk 0.9 1.0 2.1 0.0 0.9 -1.1 1.4
Eye problems/disorders: Cataract 1.1 1.3 3.1 0.7 1.0 -0.8 1.8
Mouth/teeth dental problems: Mouth ulcers 8.5 13.5 28.9 0.4 -2.8 4.2 -5.4
Medication for cholesterol 2.8 4.3 8.3 -2.9 -2.5 -1.4 0.8
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.5 1.7 3.6 1.9 0.1 1.8 0.1
Back pain experienced in last month 1.6 2.4 5.9 2.4 0.3 1.8 -0.4
Mineral and other dietary supplements 1.7 2.3 3.8 -1.0 -0.7 -1.9 -1.9
Breast cancer (self-reported) 1.5 1.8 5.9 -2.4 -0.3 -0.4 1.0
Asthma (self-reported) 0.4 0.8 2.1 0.8 0.2 1.4 0.8
Osteoporosis (self-reported) 0.3 0.4 1.0 -0.3 -1.0 0.1 0.7
Osteoarthritis (self-reported) 0.7 0.9 2.1 0.4 1.5 -0.0 1.1
Medication: Aspirin 1.0 1.4 2.8 0.0 1.1 -1.2 1.7
Medication: Gliclazide 0.8 0.9 1.3 -0.5 -0.9 -1.2 1.1
Illnesses of father: None of the above (group 1) 1.0 1.3 2.0 0.8 -1.3 -1.4 0.9
Smoking status: Current 0.4 0.6 1.9 0.3 1.4 0.4 -0.5
Forced expiratory volume in 1-second (FEV1), predicted percentage 5.5 11.7 15.7 4.0 -2.5 4.0 -3.0
Whole body water mass 2.3 13.1 30.5 -0.7 -2.6 3.8 -5.5
Leg predicted mass (right) 2.3 12.3 25.1 -0.8 -2.8 4.0 -5.0
Arm fat mass (left) 0.2 1.0 2.0 -0.1 0.5 1.3 1.4
Number of self-reported non-cancer illnesses 2.4 4.1 6.2 2.4 2.1 0.3 2.5
Average weekly champagne plus white wine intake 1.8 2.5 8.1 0.1 -1.0 0.8 -2.8
Miserableness 0.5 0.8 2.6 1.6 0.8 0.2 0.3
Guilty feelings 3.6 5.4 12.6 -2.3 -1.0 1.6 -3.5
Wears glasses or contact lenses 0.7 0.8 2.4 -1.6 -0.3 -0.9 -0.2
Ever taken oral contraceptive pill 1.9 2.1 4.1 -0.8 1.8 -0.4 2.0
Hearing aid user 1.1 1.2 3.2 -1.8 0.4 -1.1 0.6
Mother’s age at death 1.6 2.0 7.3 0.7 0.1 2.7 -0.4
Financial situation satisfaction 0.6 0.7 1.6 -1.2 -0.2 -0.7 -0.8
Tinnitus: Yes, now most or all of the time 0.5 0.6 1.0 1.0 -1.0 0.3 0.4
Commuting to job workplace: Public transport 1.5 1.8 4.6 0.5 -0.8 1.3 -2.1
Eye problems/disorders: Glaucoma 0.4 0.5 1.0 -0.9 0.4 0.1 1.0
Medication: Blood pressure 1.9 3.7 10.8 1.7 3.3 0.9 -0.4
Pain type(s) experienced in last month: Hip pain 3.6 4.6 10.2 2.1 1.9 -0.2 3.2
Supplements: Fish oil (including cod liver oil) 1.0 1.2 2.4 0.9 0.1 1.3 1.6
High cholesterol (Self-reported) 1.4 2.6 6.2 2.5 1.5 0.7 1.1
Medication: Bendroflumethiazide 0.2 0.3 0.7 0.3 0.5 -0.8 -0.2
Medication: Paracetamol 0.2 0.3 0.9 0.9 -0.4 -0.0 0.4
Medication: Lisinopril 0.9 1.2 2.8 0.1 1.0 1.7 -0.9
Medication: Atorvastatin 2.0 2.4 5.3 1.9 2.3 0.4 0.8
Illnesses of father: High blood pressure 1.2 1.5 4.4 -0.5 0.1 1.2 -2.1
Alcohol drinker status: Never 0.9 1.1 2.0 1.0 -1.4 0.6 -1.0
Ever smoked 0.1 0.2 0.3 0.5 -0.3 0.4 -0.2
Basal metabolic rate 1.7 9.6 20.8 -0.7 -2.0 3.6 -4.6
Leg fat percentage (left) 0.8 3.0 8.0 0.7 1.6 -0.9 2.8
Arm fat-free mass (left) 1.8 9.1 23.2 -0.2 -1.9 3.1 -4.8
Number of operations (self-reported) 2.9 4.3 8.4 1.5 -2.9 1.1 -2.3
Average weekly beer plus cider intake 0.5 0.7 1.3 1.1 0.2 0.8 -0.9
Irritability 0.3 0.6 1.3 1.2 -0.2 0.6 -0.7
Risk taking 0.9 1.3 2.6 1.3 -0.3 0.9 -1.6
Ever had prostate specific antigen (PSA) test 0.3 0.3 0.9 -0.4 -1.0 -0.4 -0.4
Fractured/broken bones in last 5 years 0.4 0.6 2.0 -0.0 -0.2 0.5 1.4
Age started oral contraceptive pill 0.1 0.1 0.2 -0.5 0.3 0.1 -0.1
Diastolic blood pressure, automated reading 0.6 1.9 4.1 2.0 -0.8 0.9 -1.5
Ever depressed for a whole week 0.9 1.1 3.2 1.8 -0.5 0.9 -0.5
Unable to work because of sickness or disability 0.3 0.3 0.5 0.6 0.7 0.7 -0.0
Commuting to job workplace: Cycle 1.1 1.3 4.4 -2.1 0.5 0.5 -0.4
Myopia 2.0 2.9 5.2 1.8 0.5 2.3 -1.7
Vascular/heart problems diagnosed by doctor 1.5 4.2 9.4 -2.3 -3.1 -1.3 0.5
Cholesterol lowering medication 0.8 1.3 2.3 1.3 1.5 0.7 0.7
Medication: Omeprazole (e.g. Zanprol) 3.0 3.6 8.4 -1.2 1.5 -1.5 2.9
Pain experienced in last month 2.4 4.0 7.9 -2.7 -0.6 -2.8 0.5
Supplements: Calcium 1.2 1.4 3.6 -0.2 0.7 1.1 1.9
Basal cell carcinoma (self-reported) 5.1 6.0 8.3 -2.8 1.6 -2.3 2.9
Heart attack/myocardial infarction (self-reported) 0.8 1.0 1.8 1.4 1.1 -0.6 0.8
Deep venous thrombosis (DVT) (self-reported) 0.2 0.3 0.8 0.6 -0.1 0.9 0.4
Heart disease (siblings) 1.3 1.6 3.9 1.2 2.0 -0.1 1.1
Alcohol drinker status: Previous 1.2 1.3 2.8 1.7 -0.7 -1.4 -0.6
Pack years of smoking 1.1 1.6 3.9 -1.3 -0.9 0.0 -2.0
Impedance of whole body 3.9 20.1 50.8 -2.3 3.7 -3.3 7.1
Leg fat mass (left) 0.1 0.5 1.4 -0.1 0.8 0.4 1.2
Arm predicted mass (left) 1.6 8.3 21.5 -0.4 -1.6 3.0 -4.6