Best TWAS P=1.2e-24 · Best GWAS P=3.55e-48 conditioned to 1.44e-32
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Cortex | HAPLN3 | 0.40 | -0.01 | lasso | 5 | -0.01 | 6.0e-01 | -3.0 | -7.1 | 9.1e-13 | -0.04 | 0.05 | 0.11 | TRUE |
| 2 | GTEx | Heart Left Ventricle | MFGE8 | 0.11 | 0.03 | lasso | 6 | 0.05 | 1.8e-03 | -4.7 | 5.6 | 2.1e-08 | 0.03 | 0.11 | 0.04 | FALSE |
| 3 | GTEx | Lung | MFGE8 | 0.12 | 0.04 | lasso | 5 | 0.06 | 1.4e-05 | -6.2 | 5.2 | 2.4e-07 | -0.03 | 0.78 | 0.01 | FALSE |
| 4 | GTEx | Nerve Tibial | MFGE8 | 0.21 | 0.07 | enet | 17 | 0.12 | 1.0e-08 | -4.6 | 5.9 | 3.5e-09 | 0.01 | 0.98 | 0.00 | TRUE |
| 5 | GTEx | Testis | FANCI | 0.19 | 0.04 | enet | 21 | 0.09 | 1.3e-04 | -3.3 | -6.8 | 1.3e-11 | -0.08 | 0.18 | 0.14 | TRUE |
| 6 | GTEx | Whole Blood | MFGE8 | 0.12 | 0.14 | lasso | 4 | 0.13 | 9.3e-12 | -5.6 | -5.9 | 4.4e-09 | -0.01 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Whole Blood | ISG20 | 0.13 | 0.11 | lasso | 3 | 0.11 | 4.9e-10 | 5.4 | 5.3 | 9.0e-08 | -0.04 | 1.00 | 0.00 | TRUE |
| 8 | The Cancer Genome Atlas | Colon Adenocarcinoma | HAPLN3 | 0.14 | 0.04 | lasso | 4 | 0.08 | 1.7e-05 | 4.0 | -10.2 | 1.2e-24 | 0.43 | 0.05 | 0.58 | TRUE |
| 9 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | MFGE8 | 0.18 | 0.01 | lasso | 4 | 0.04 | 9.9e-03 | 4.3 | -6.4 | 1.9e-10 | -0.01 | 0.04 | 0.05 | TRUE |