[Hub]/) : Traits : Sitting height :

chr15:88,483,456-90,551,003

Best TWAS P=1.2e-24 · Best GWAS P=3.55e-48 conditioned to 1.44e-32

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 GTEx Brain Cortex HAPLN3 0.40 -0.01 lasso 5 -0.01 6.0e-01 -3.0 -7.1 9.1e-13 -0.04 0.05 0.11 TRUE
2 GTEx Heart Left Ventricle MFGE8 0.11 0.03 lasso 6 0.05 1.8e-03 -4.7 5.6 2.1e-08 0.03 0.11 0.04 FALSE
3 GTEx Lung MFGE8 0.12 0.04 lasso 5 0.06 1.4e-05 -6.2 5.2 2.4e-07 -0.03 0.78 0.01 FALSE
4 GTEx Nerve Tibial MFGE8 0.21 0.07 enet 17 0.12 1.0e-08 -4.6 5.9 3.5e-09 0.01 0.98 0.00 TRUE
5 GTEx Testis FANCI 0.19 0.04 enet 21 0.09 1.3e-04 -3.3 -6.8 1.3e-11 -0.08 0.18 0.14 TRUE
6 GTEx Whole Blood MFGE8 0.12 0.14 lasso 4 0.13 9.3e-12 -5.6 -5.9 4.4e-09 -0.01 1.00 0.00 FALSE
7 GTEx Whole Blood ISG20 0.13 0.11 lasso 3 0.11 4.9e-10 5.4 5.3 9.0e-08 -0.04 1.00 0.00 TRUE
8 The Cancer Genome Atlas Colon Adenocarcinoma HAPLN3 0.14 0.04 lasso 4 0.08 1.7e-05 4.0 -10.2 1.2e-24 0.43 0.05 0.58 TRUE
9 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma MFGE8 0.18 0.01 lasso 4 0.04 9.9e-03 4.3 -6.4 1.9e-10 -0.01 0.04 0.05 TRUE