TWAS hub - HAPLN3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Brain Cortex	0.3960	0.1290	4.7e-03	-0.005	NA	-0.008	NA	-0.008	4.8e-01	NA	6.3e-01	NA	6.0e-01
2	GTEx	Brain Hippocampus	0.4945	0.1298	9.9e-04	0.127	NA	0.012	NA	0.094	6.8e-04	NA	1.7e-01	NA	3.2e-03
3	YFS	Blood	0.0292	0.0115	1.7e-03	0.014	0.007	0.021	0.015	0.017	2.1e-05	1.9e-03	1.8e-07	9.9e-06	2.5e-06
4	TCGA	Colon Adenocarcinoma	0.1360	0.0550	6.2e-04	0.039	0.041	0.038	NA	0.082	2.7e-03	2.2e-03	2.9e-03	NA	1.7e-05
5	TCGA	Brain Lower Grade Glioma	0.1726	0.0485	3.8e-08	0.100	0.100	0.082	NA	0.093	2.0e-11	1.8e-11	1.3e-09	NA	9.6e-11

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Height	5.6	107.1	324.0	-13.4	3.7	1.8	-18.0	3.9
Comparative height size at age 10	5.6	30.6	97.4	-7.0	1.5	1.7	-9.9	1.4
Standing height	5.2	52.1	171.7	-8.9	1.9	1.1	-13.1	2.2
Sitting height	4.4	31.5	104.0	-7.1	0.8	1.1	-10.2	0.7
Pain all over the body in last month	4.4	4.7	6.9	-2.2	-2.4	-2.4	0.6	-2.6
Commuting to job workplace: Cycle	3.5	4.3	17.3	-1.2	-0.5	0.5	4.2	-1.5
Long-standing illness, disability or infirmity	3.2	4.9	9.5	-0.9	-3.1	-1.3	1.8	-3.0
Ever smoked	3.1	5.4	14.1	-3.8	3.4	-0.3	-0.9	0.9
Bipolar Disorder (2011)	2.8	2.7	4.4	0.7	1.8	1.1	2.1	2.0
Past tobacco smoking	2.8	5.2	16.9	2.6	-4.1	-0.1	0.6	-1.4
Forced vital capacity (FVC)	2.6	9.9	32.6	-3.7	-1.3	-1.3	-5.7	0.3
Trunk fat-free mass	2.6	15.2	37.6	-5.2	-0.2	2.8	-6.1	1.9
Trunk predicted mass	2.6	15.0	36.5	-5.2	-0.1	2.8	-6.0	1.9
Heart attack/myocardial infarction (self-reported)	2.6	3.4	5.8	0.5	-2.3	-0.2	2.3	-2.4
Heart attack	2.5	3.2	6.0	0.5	-2.5	-0.2	2.0	-2.4
Forced vital capacity (FVC), Best measure	2.5	9.0	35.0	-2.7	-1.6	-0.2	-5.9	0.1
Commuting to job workplace: Car/motor vehicle	2.5	2.8	10.6	1.4	3.3	0.3	-0.7	1.1
Hearing aid user	2.5	2.8	5.7	1.0	1.5	2.1	-2.4	-0.7
Whole body fat-free mass	2.4	13.5	33.0	-4.8	-0.7	2.6	-5.7	1.9
Ever had bowel cancer screening	2.3	2.7	6.8	-2.6	2.4	-0.3	-0.5	0.7
Whole body water mass	2.3	13.2	32.2	-4.8	-0.7	2.6	-5.7	1.9
Tinnitus: Yes, but not now, but have in the past	2.2	2.3	6.7	1.0	-0.1	0.8	1.8	-2.6
Smoking status: Previous	2.2	3.2	13.1	-1.6	3.6	0.0	-0.1	0.7
Medication: Lisinopril	2.2	2.8	6.7	-0.0	-1.6	2.1	-2.6	0.6
Basal metabolic rate	2.2	12.0	31.0	-4.4	-0.8	2.5	-5.6	1.7
Medication: Omeprazole (e.g. Zanprol)	2.1	2.5	5.1	1.5	-2.3	-1.4	0.7	-1.6
Medication: Co-codamol	2.0	2.4	4.1	1.2	-2.0	2.0	1.4	-0.7
Leg fat-free mass (left)	2.0	10.6	26.1	-4.2	-1.4	2.3	-5.1	1.4
Leg predicted mass (left)	2.0	10.5	26.6	-4.1	-1.4	2.3	-5.2	1.4
Exposure to tobacco smoke at home	2.0	2.2	5.7	0.1	1.3	1.8	2.4	-0.7
Arm fat-free mass (right)	2.0	10.5	28.1	-3.9	-1.0	2.0	-5.3	2.1
Arm predicted mass (right)	2.0	10.0	28.5	-3.6	-0.9	1.9	-5.3	2.0
Forced expiratory volume in 1-second (FEV1), predicted	2.0	4.2	14.5	-1.9	-0.2	1.3	-3.8	1.1
Arm fat-free mass (left)	2.0	10.2	27.3	-3.7	-0.1	2.3	-5.2	2.2
Hair/balding pattern: Pattern 2	1.9	2.5	5.6	-2.0	-0.2	0.5	-1.6	-2.4
Comparative body size at age 10	1.9	5.3	11.9	3.4	-1.5	-1.5	3.1	1.0
Emphysema/chronic bronchitis	1.9	2.2	4.5	-2.1	0.9	-1.8	-0.9	1.3
Leg fat-free mass (right)	1.9	10.3	23.2	-4.3	-1.4	2.2	-4.8	1.6
Leg predicted mass (right)	1.9	10.3	23.1	-4.3	-1.5	2.2	-4.8	1.6
LDL Cholesterol	1.8	2.8	6.5	-2.2	-1.4	-0.9	-0.3	-2.6
Depression (self-reported)	1.8	2.1	6.5	-0.6	-1.1	-1.2	2.6	-1.1
Eye problems/disorders: Cataract	1.8	2.1	6.1	-0.8	-2.5	-0.1	1.7	-0.9
Arm predicted mass (left)	1.8	9.2	25.1	-3.6	-0.2	2.0	-5.0	2.1
Medication: Amlodipine	1.7	2.4	9.4	-1.2	-0.3	-0.2	-3.1	1.1
Birth weight	1.7	3.6	6.7	1.3	2.3	2.6	0.8	1.9
Unable to work because of sickness or disability	1.7	2.3	8.8	-1.0	-3.0	0.5	1.0	-0.7
Pack years of smoking	1.7	2.4	5.8	2.4	-1.6	-1.9	-0.3	0.6
Diverticular disease/diverticulitis (self-reported)	1.6	1.8	4.3	-1.2	2.1	1.6	0.9	0.0
Weight	1.6	8.0	26.9	-2.7	-0.7	2.0	-5.2	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.6	5.0	19.8	-1.2	-1.9	-0.3	-4.5	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	1.6	1.7	4.5	2.1	0.0	1.8	0.7	0.2
Illnesses of siblings	1.5	2.1	7.9	0.5	1.1	-2.8	0.6	1.1
Lung cancer (father)	1.5	1.8	4.8	-0.0	-1.2	2.2	-0.1	-1.6
Gout (self-reported)	1.5	2.0	6.6	-2.6	0.5	0.3	0.9	-1.6
Medication: Omeprazole	1.5	1.8	3.0	1.1	-1.7	-0.4	1.2	-1.7
Knee pain experienced in last month	1.5	2.3	5.1	0.5	2.3	1.3	-1.4	1.6
Alcohol drinker status: Never	1.5	1.8	3.7	-0.4	-1.4	-0.8	-1.9	-1.7
Medication: Atenolol	1.4	1.7	4.8	-0.6	-0.1	2.2	-0.1	-1.8
Forced expiratory volume in 1-second (FEV1)	1.4	4.8	18.5	-1.6	-1.6	-0.7	-4.3	0.2
Medication: Lansoprazole	1.4	1.6	3.5	1.9	-1.2	-1.3	1.0	0.3
Pulse wave Arterial Stiffness index	1.4	1.6	7.3	0.0	0.5	-0.3	-2.7	-0.6
Medication: Ibuprofen	1.4	1.7	4.5	1.5	-1.1	-0.7	0.3	2.1
Eye problems/disorders: Glaucoma	1.4	1.6	5.1	0.7	1.2	0.1	0.9	-2.2
Smoking Status	1.3	3.2	6.8	-2.6	2.6	-0.8	0.3	1.4
Medication for hormone replacement therapy	1.3	1.5	4.7	2.2	-1.0	0.9	-0.7	0.5
Diabetes (mother)	1.3	1.6	5.9	-0.4	-1.0	0.5	-1.0	-2.4
Pack years adult smoking proportion	1.3	2.0	4.8	2.2	-1.5	-1.5	0.1	0.6
Falls in the last year	1.3	1.7	3.6	-1.0	-1.8	1.9	0.1	-0.8
Birth weight of first child	1.3	2.3	5.8	-1.5	2.4	-0.2	-1.7	0.8
Medication: Allopurinol	1.3	1.8	3.0	-1.7	0.5	1.0	1.4	-1.6
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	2.9	1.7	-1.1	-0.4	1.6	-0.8
Illness, injury, bereavement, stress in last 2 years	1.3	1.6	7.1	0.1	0.4	2.7	0.8	-0.3
Age started oral contraceptive pill	1.3	1.7	4.5	-1.2	2.1	-0.8	-1.1	-0.5
Supplements: Glucosamine	1.2	1.6	4.8	-0.3	0.1	-1.2	-2.2	1.4
Trunk fat mass	1.2	5.3	22.7	-1.4	-0.6	0.9	-4.8	0.7
Medication: Ramipril	1.2	1.6	2.6	-1.6	-0.7	-0.7	1.3	-1.6
Alcohol intake versus 10 years previously	1.2	1.7	4.7	1.0	2.2	-1.0	-0.2	1.4
Headache pain in last month	1.2	2.0	7.4	0.5	-0.9	2.7	-0.6	1.1
Glaucoma (self-reported)	1.2	1.4	5.2	1.0	0.5	0.3	0.7	-2.3
High blood pressure (siblings)	1.2	1.7	4.6	-1.3	-1.1	2.1	-0.9	-0.4
Shortness of breath walking on level ground	1.2	1.4	3.6	-0.6	-1.7	0.6	-1.9	-0.3
Medication: Aspirin	1.2	1.6	7.0	0.6	0.5	0.1	-0.4	-2.6
Medication: Paracetamol	1.2	1.9	6.0	2.4	-1.3	0.9	0.8	-0.6
Alzheimer’s Disease (in father)	1.1	1.2	2.1	1.1	-0.7	1.3	0.5	-1.5
Crohns Disease (2017)	1.1	2.4	5.8	1.5	1.5	2.4	1.3	-0.1
Crohns Disease (2012)	1.1	1.7	5.5	0.3	1.4	2.3	-1.0	-0.1
Fasting Glucose	1.1	1.3	3.2	0.9	-0.8	1.3	0.4	-1.8
HbA1C	1.1	1.3	2.8	0.7	-1.7	-0.1	0.6	-1.7
Hand grip strength (left)	1.1	2.9	6.8	-1.6	-0.3	-0.7	-2.6	2.1
Taking other prescription medications	1.1	1.7	2.7	-1.5	-1.4	-1.6	1.1	-0.7
Chronic bronchitis/emphysema (father)	1.1	1.3	2.8	1.7	-0.0	-0.3	1.3	1.3
Frequency of tiredness / lethargy in last 2 weeks	1.1	1.7	3.1	0.7	-1.4	1.8	0.8	-1.5
Number of live births	1.1	1.5	4.0	1.4	-1.3	0.2	-2.0	0.1
Happiness	1.1	1.4	4.8	-0.2	-0.9	-1.1	-0.3	-2.2
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.5	4.2	1.5	-0.9	-0.2	0.2	2.0
Qualifications: O levels/GCSEs or equivalent	1.1	1.7	2.9	-1.5	-1.7	-0.5	0.6	-1.7
Health satisfaction	1.1	1.4	4.2	2.0	-0.9	-1.0	-0.2	-1.1
Medication: Seretide 50 evohaler	1.1	1.2	3.2	-0.6	-1.0	-1.0	1.8	0.8
Number of full sisters	1.1	1.3	5.4	-0.4	2.3	0.3	-0.3	1.1
Medication: Aspirin	1.1	1.4	5.5	0.9	0.8	0.0	-0.3	-2.3
Osteoarthritis (self-reported)	1.1	1.5	4.8	-0.5	-0.3	2.2	-0.5	-1.4
Illnesses of father: None of the above (group 1)	1.1	1.4	4.1	-1.5	2.0	0.7	0.1	-0.1
Wears glasses or contact lenses	1.1	1.2	4.1	-0.6	2.0	0.4	-1.2	-0.2
Schizophrenia (2018)	1.0	2.1	6.9	-1.1	2.6	1.4	-0.6	0.5
Lupus	1.0	1.5	4.1	0.3	-0.1	-0.1	2.0	-1.8
Impedance of leg (left)	1.0	4.7	8.2	0.7	2.6	-2.9	-2.8	-0.4
Serious illness, injury or assault of a close relative in last 2 years	1.0	1.2	5.2	-0.6	0.4	-2.3	0.3	-0.4
Hair/balding pattern: Pattern 4	1.0	2.4	6.1	2.5	1.0	-0.8	0.1	2.1
Chronic bronchitis/emphysema (mother)	1.0	1.1	3.1	-0.5	1.5	0.1	0.1	1.8
Eye problems/disorders: None of the above	1.0	1.2	2.6	0.2	1.1	0.4	-1.5	1.6
Supplements: Vitamin C	1.0	1.2	6.0	0.2	2.4	0.4	0.1	0.1
Qualifications: nursing, teaching	1.0	1.6	4.5	-0.3	0.1	1.2	2.1	1.4
Medication for cholesterol	1.0	1.5	3.3	0.3	1.2	-1.8	1.5	0.8
Back pain experienced in last month	1.0	1.5	4.8	1.3	1.0	-0.1	-0.4	2.2
Breast cancer (self-reported)	1.0	1.1	3.3	-0.4	-1.4	-0.0	-1.8	-0.3
Number of self-reported non-cancer illnesses	1.0	1.7	7.1	-2.7	-0.7	0.4	-0.3	-0.7
Ever had prostate specific antigen (PSA) test	1.0	1.2	4.1	1.1	-0.2	2.0	0.2	-0.8
Bipolar Disorder or Schizophrenia	0.9	2.1	4.1	-2.0	1.5	1.8	-0.9	0.2
Mean Putamen Volume	0.9	1.1	5.0	0.1	-0.5	0.2	-2.2	0.0
Schizophrenia (2014)	0.9	2.1	3.8	-1.3	1.9	1.9	-1.0	0.3
Hearing difficulty/problems: Yes	0.9	1.4	5.5	1.1	0.3	0.1	-2.3	0.6
Relative age of first facial hair	0.9	1.7	3.5	1.5	-0.1	0.4	1.9	1.6
Impedance of leg (right)	0.9	4.2	8.3	0.6	2.4	-2.4	-2.9	-0.8
Bilateral oophorectomy (both ovaries removed)	0.9	1.1	2.4	-1.5	1.5	-0.2	0.3	0.8
Stomach or abdominal pain in last month	0.9	1.1	3.1	-0.3	0.6	1.8	1.4	0.1
Hair/balding pattern: Pattern 3	0.9	1.3	4.2	2.1	-0.9	0.2	0.0	-1.2
Tense / ‘highly strung’	0.9	1.4	3.5	0.5	-0.6	1.9	-1.1	-1.4
Mouth/teeth dental problems: Bleeding gums	0.9	1.1	2.9	-0.1	0.5	-0.4	1.5	1.7
Worry too long after embarrassment	0.9	1.4	2.7	1.1	-0.4	1.3	1.1	-1.6
Number of children fathered	0.9	1.0	2.6	-0.1	1.2	0.5	1.6	1.0
Commuting to job workplace: Public transport	0.9	1.1	3.6	0.6	-1.9	-1.1	0.1	-0.6
Average weekly beer plus cider intake	0.9	1.3	3.1	-0.9	0.8	1.8	0.7	-1.1
Myopia	0.9	1.3	3.1	-1.6	0.7	-0.1	0.0	1.8
Impedance of whole body	0.9	4.7	8.9	-0.2	2.2	-3.0	-3.0	-0.7
Bipolar Disorder (2018)	0.8	1.3	3.8	-1.9	-0.9	1.2	-0.7	-0.1
Depression (Nagel 2018)	0.8	1.2	3.3	1.8	0.7	1.3	0.6	-0.4
Irritable Bowel Disease (IBD)	0.8	2.0	4.9	1.2	1.6	2.2	0.8	0.5
Ovarian Cancer	0.8	1.1	4.1	2.0	0.6	-0.3	-0.9	0.5
Ulcerative Colitis	0.8	1.2	3.4	1.0	0.8	1.8	-1.0	-0.0
Sensitivity / hurt feelings	0.8	1.4	2.8	-1.7	1.7	-0.2	1.0	-0.6
High blood pressure	0.8	2.2	10.0	-0.8	-0.1	-0.1	-3.2	0.4
Alcohol usually taken with meals	0.8	1.3	3.1	-0.2	-0.4	-1.6	-1.8	-0.8
Hearing difficulty/problems with background noise	0.8	1.3	2.3	-1.5	1.0	1.5	-0.9	-0.5
Impedance of arm (right)	0.8	3.6	6.5	-1.0	2.1	-2.3	-2.5	-0.7
Peak expiratory flow (PEF)	0.8	1.9	3.6	0.2	1.3	-0.9	-1.9	1.8
Ever highly irritable/argumentative for 2 days	0.8	0.9	2.2	0.8	-0.2	-1.5	-0.9	-0.9
Mouth/teeth dental problems: Loose teeth	0.8	1.0	2.8	-0.0	-1.7	-0.7	-1.2	0.4
Medication for pain relief, constipation, heartburn	0.8	1.4	4.3	-2.1	1.2	0.7	-0.5	0.9
Whole body fat mass	0.8	3.4	14.9	-0.7	-0.6	0.9	-3.9	0.5
Family relationship satisfaction	0.8	1.0	2.4	0.5	-1.3	0.3	-0.6	-1.6
Illnesses of father: Heart disease	0.8	1.1	3.3	-0.5	-0.6	-1.8	-0.9	0.8
Average weekly red wine intake	0.8	1.2	1.9	-1.2	-0.9	-0.8	-1.1	-1.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.8	0.9	2.7	-0.7	-0.5	1.2	1.6	-0.1
Miserableness	0.8	1.4	2.9	-1.4	1.2	1.7	0.7	0.0
Financial situation satisfaction	0.8	1.0	4.1	0.5	-2.0	0.8	-0.4	-0.3
Medication: Bendroflumethiazide	0.8	1.2	3.5	-0.9	0.2	1.1	-1.9	-0.7
Pain experienced in last month	0.8	1.3	3.4	-0.6	0.8	-0.1	1.4	-1.8
Intelligence (Savage-Jansen 2018)	0.7	2.1	6.7	-1.5	2.6	-0.3	0.8	1.0
Alzheimer’s Disease (including proxy)	0.7	1.0	2.8	0.4	-0.8	1.2	-0.5	-1.7
Major Depression (MDD)	0.7	0.9	2.2	1.5	-0.8	-1.2	0.0	0.0
Coronary Artery Disease (CAD)	0.7	0.9	2.7	1.6	-0.5	0.2	-1.1	-0.4
Type 2 Diabetes (T2D) (2012)	0.7	0.8	1.3	0.8	-1.1	0.4	-1.1	0.7
Hypothyroidism (self reported)	0.7	1.6	5.5	-1.0	-0.5	-1.1	-2.3	0.3
Ever used hormone-replacement therapy (HRT)	0.7	0.9	1.9	1.4	-1.3	0.1	-0.6	-0.7
Ever had hysterectomy (womb removed)	0.7	0.8	1.2	1.1	0.8	-1.0	0.1	0.9
Severe depression (siblings)	0.7	0.7	1.8	-1.4	0.8	1.1	0.3	0.2
Hand grip strength (right)	0.7	1.8	6.7	-1.0	-0.2	-0.3	-2.6	1.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	1.0	2.3	1.5	0.7	1.4	0.4	-0.1
Qualifications: CSEs or equivalent	0.7	1.0	1.9	1.1	-0.5	1.4	0.4	1.1
Number of incorrect matches in round	0.7	1.2	2.5	-1.2	1.1	0.3	0.8	-1.6
Had menopause	0.7	0.8	2.5	0.5	-0.9	-0.6	-1.6	-0.4
Medication: Simvastatin	0.7	1.1	2.3	-1.5	-0.1	0.5	-1.4	-0.9
Hip circumference	0.7	2.9	6.5	-1.4	-1.0	2.6	-2.3	0.3
Medication: Cholesterol lowering	0.7	1.1	1.8	0.9	-0.6	-1.3	-1.3	-1.1
Illnesses of mother	0.7	0.8	1.3	1.1	-0.9	1.1	0.8	0.5
Impedance of arm (left)	0.7	3.2	6.1	-0.9	1.8	-2.2	-2.5	-1.0
Length of working week for main job	0.7	0.8	2.1	0.3	-1.4	0.3	0.6	1.2
Loud music exposure frequency	0.7	0.8	2.5	0.5	-0.4	0.8	0.5	1.6
Blood clot in the leg (DVT)	0.7	0.9	2.2	0.5	-1.2	-0.3	1.5	-0.5
Migraine (self-reported)	0.7	0.8	3.6	-0.1	0.1	0.7	1.9	0.2
Heart disease (mother)	0.7	0.9	2.6	-0.5	-1.2	-0.6	-0.0	-1.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	2.2	-0.3	-0.5	-1.5	0.1	1.3
Leg fat mass (right)	0.7	2.7	11.5	0.2	-0.8	1.1	-3.4	0.5
Alcohol intake frequency.	0.7	1.5	4.8	2.2	-1.1	1.2	-0.0	-0.6
Hypertension (Self-reported)	0.7	1.9	8.3	-0.8	-0.6	0.4	-2.9	0.1
Diabetes diagnosed by doctor	0.7	1.2	2.9	0.5	-1.7	0.3	1.2	-1.2
Osteoporosis (self-reported)	0.7	0.9	2.3	-0.4	0.3	-1.5	0.2	1.3
Medication: Blood pressure	0.7	1.3	2.1	-1.4	-0.3	1.3	-1.3	-1.1
Pain type(s) experienced in last month: Hip pain	0.7	0.8	3.0	-1.0	1.7	0.4	0.1	-0.3
Number of operations (self-reported)	0.7	1.1	3.0	0.4	1.7	0.3	1.3	0.5
Ever depressed for a whole week	0.7	0.8	1.7	-0.5	1.3	-0.7	-1.3	-0.3
Cholesterol lowering medication	0.7	1.1	3.5	-1.9	0.6	0.9	0.1	-0.9
Deep venous thrombosis (DVT) (self-reported)	0.7	0.9	2.4	0.7	-1.1	-0.1	1.5	-0.8
Leg fat mass (left)	0.7	2.8	11.7	0.4	-0.8	1.0	-3.4	0.7
Schizophrenia vs Biploar Disorder	0.6	0.8	2.0	0.3	0.2	1.4	-1.4	-0.1
Reaction Time	0.6	1.1	2.8	-1.6	0.3	0.1	1.7	-0.3
Blood Platelet Count	0.6	6.6	16.4	4.1	-2.6	-1.9	2.5	-0.3
Type 2 Diabetes (T2D) (2018)	0.6	1.1	3.6	-0.7	-1.9	0.0	-0.1	-1.3
Neuroticism	0.6	1.4	2.4	-0.6	-1.0	1.5	0.9	-1.5
Supplements: Zinc	0.6	0.7	1.6	0.7	1.3	0.4	-0.9	-0.6
Trunk fat percentage	0.6	2.5	12.2	-0.2	-0.4	0.1	-3.5	0.3
Townsend deprivation index at recruitment	0.6	0.8	3.4	-0.5	0.2	-0.5	1.8	0.4
Relative age voice broke	0.6	0.9	2.0	-0.1	1.4	-0.6	0.7	1.3
Age when periods started (menarche)	0.6	1.4	5.3	0.7	-0.8	-0.7	-2.3	0.1
Hayfever, allergic rhinitis or eczema	0.6	1.2	2.6	-1.3	-1.6	-0.9	-0.7	-0.8
Allergy	0.6	1.4	5.4	2.3	0.7	0.9	-0.2	0.5
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	1.8	-1.4	0.4	-1.0	0.9	-0.6
Fluid intelligence score	0.6	1.3	4.4	-0.5	1.1	0.5	2.1	-0.6
Father’s age at death	0.6	0.8	1.9	-0.7	1.1	-0.5	1.4	0.5
Breastfed as a baby	0.6	0.8	3.0	-1.7	-0.4	-0.3	-0.3	-0.7
Medication: Paracetamol	0.6	1.0	2.8	1.7	-1.2	0.4	0.9	0.3
Seen a psychiatrist for nerves, anxiety, tension or depression	0.6	0.8	2.8	-0.3	-1.1	-0.2	0.1	1.7
Pulse wave peak to peak time	0.6	0.7	2.0	-0.9	-0.1	0.4	1.4	0.8
Medication: Blood pressure	0.6	1.0	2.7	-1.2	-0.1	-0.8	-1.6	-0.1
Suffer from ‘nerves’	0.6	0.9	2.9	0.9	-1.7	0.6	0.4	-0.5
Had major operations	0.6	0.7	2.6	1.6	-0.6	0.6	0.3	0.3
Illnesses of siblings: Diabetes	0.6	0.8	2.2	0.9	0.2	1.0	-0.1	-1.5
Loneliness, isolation	0.6	0.8	2.9	0.4	-1.7	0.2	0.7	0.7
Friendships satisfaction	0.6	0.7	1.6	0.9	0.0	0.8	0.6	-1.3
Commuting to job workplace: Walk	0.6	0.6	1.6	-0.7	-0.5	0.7	0.3	-1.3
Mineral and other dietary supplements	0.6	0.9	2.4	-0.6	-1.6	-0.5	-0.2	-1.1
Average weekly champagne plus white wine intake	0.6	0.9	2.7	-1.6	0.2	0.6	0.9	-0.8
Mother’s age at death	0.6	0.8	3.3	0.5	0.0	-1.8	-0.5	0.2
Illnesses of father: High blood pressure	0.6	0.7	2.2	0.6	0.1	0.7	-1.5	0.6
Vascular/heart problems diagnosed by doctor	0.6	1.6	7.0	0.5	0.7	0.3	2.6	0.4
Supplements: Calcium	0.6	0.7	1.5	1.2	0.9	0.0	-1.0	0.0
Ulcerative Colitis (UC)	0.5	1.0	3.1	0.4	1.8	1.2	-0.4	0.6
Breast Cancer	0.5	1.3	2.8	0.5	-1.0	0.5	-1.4	1.7
Body Mass Index (BMI) (2010)	0.5	0.6	1.3	1.2	-0.9	-0.7	0.8	0.0
Primary Biliary Cirrhosis	0.5	0.7	1.3	0.3	-0.9	1.1	-0.4	-0.9
Heel T-Score	0.5	4.4	11.0	1.0	-3.3	-1.0	2.5	-1.6
Cardiovascular Disease	0.5	1.8	7.7	-0.5	-0.8	0.4	-2.8	-0.4
Frequency of depressed mood in last 2 weeks	0.5	0.8	1.8	1.4	0.4	1.1	-0.0	-0.8
Systolic blood pressure, automated reading	0.5	1.6	3.9	-0.2	2.0	1.0	-1.7	-0.3
Angina	0.5	0.7	1.7	0.1	0.2	-0.7	-1.0	-1.3
Vitamin and mineral supplements	0.5	0.7	2.2	0.4	-1.5	-0.7	0.3	0.6
Diabetes (father)	0.5	0.7	2.4	0.7	-0.5	0.2	1.5	0.4
Multivitamins +/- minerals	0.5	0.6	1.2	-0.7	1.1	-1.0	-0.0	-0.6
Waist circumference	0.5	2.0	4.3	-0.4	-1.4	1.6	-2.1	1.0
Noisy workplace	0.5	0.6	1.7	-0.0	-0.9	-1.3	-0.5	-0.2
Prospective memory result	0.5	0.6	2.5	-0.0	0.6	0.6	-1.6	0.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.5	0.8	1.3	-0.8	1.1	-0.4	0.9	1.0
Medication for cholesterol, blood pressure or diabetes	0.5	0.8	2.4	-0.0	0.0	0.4	1.5	1.1
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	1.9	-1.4	-0.2	-1.1	-1.2	-0.8
Exposure to tobacco smoke outside home	0.5	0.7	1.2	1.1	0.7	0.6	0.9	0.6
Angina (self-reported)	0.5	0.6	1.6	0.1	0.4	-0.6	-1.1	-1.2
Overall health rating	0.5	1.0	4.1	0.2	-0.8	-0.4	0.0	-2.0
Chest pain or discomfort	0.5	0.7	1.4	-1.2	0.5	0.9	-0.1	-0.9
Age at last live birth	0.5	0.7	2.1	-0.3	-0.5	1.5	-0.8	-0.5
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.0	-0.2	-1.4	-0.2	1.2	-0.6
Medication: Gliclazide	0.5	0.5	1.1	0.5	-0.1	0.5	1.0	-1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.1	3.4	1.1	-0.6	-0.1	-1.9	-0.7
Guilty feelings	0.5	0.7	1.4	-0.5	0.7	1.0	0.6	-1.2
High cholesterol (Self-reported)	0.5	0.8	2.7	-1.1	-0.5	-0.0	-1.6	-0.0
Basal cell carcinoma (self-reported)	0.5	0.6	1.9	-0.8	0.3	-1.4	-0.4	-0.2
Heart disease (siblings)	0.5	0.6	1.4	-0.6	-1.2	0.0	0.5	-1.1
Alzheimer’s Disease (in mother)	0.4	0.5	1.5	-0.3	-0.8	-0.3	-0.2	-1.2
Verbal and Numeric Reasoning (VNR)	0.4	0.9	1.5	-0.5	1.2	1.2	0.9	-0.7
Age at First Birth	0.4	0.6	2.3	-0.1	0.3	0.9	-1.5	-0.2
HDL Cholesterol	0.4	0.6	2.8	-0.2	-0.4	0.0	-1.7	-0.1
Allergy or Eczema	0.4	1.0	1.6	-0.8	-1.0	-0.2	-1.2	-1.3
Lung FEV1/FVC ratio	0.4	1.9	8.3	2.9	-1.0	-0.5	0.1	0.3
Number of treatments/medications taken	0.4	0.6	1.4	-0.7	-1.1	0.4	0.0	-1.2
Eye problems/disorders: Diabetes related eye disease	0.4	0.4	1.7	-0.0	0.1	0.3	1.3	-0.6
Medication: Metformin	0.4	0.6	1.7	1.3	-1.0	0.6	0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.7	1.3	-1.1	-1.0	-0.1	-0.5
Medication: Levothyroxine sodium	0.4	0.6	2.0	-0.3	0.3	0.7	-1.4	-0.6
High blood pressure (mother)	0.4	0.5	1.7	-0.0	-1.3	0.6	-0.7	0.2
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.6	1.9	0.3	1.0	1.4	-0.4	0.1
Heel bone mineral density (BMD) T-score, automated (right)	0.4	0.8	1.5	1.2	-1.1	-0.4	-0.3	-1.0
Qualifications: None of the above	0.4	0.8	2.1	-0.3	1.3	0.2	-1.5	-0.3
Financial difficulties in last 2 years	0.4	0.5	1.0	-0.1	1.0	-0.7	-0.8	0.6
Diabetes (self-reported)	0.4	0.7	1.1	0.4	-1.1	0.5	0.9	-1.1
Pulse rate	0.4	0.6	2.3	1.5	-0.6	-0.1	0.4	0.5
Mouth/teeth dental problems: Dentures	0.4	0.6	1.7	0.1	0.8	1.3	-0.8	-0.5
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.7	0.4	-0.1	1.3	-0.6	0.6
Body fat percentage	0.4	1.5	6.4	0.8	-0.3	0.3	-2.5	0.3
Leg fat percentage (right)	0.4	1.5	4.3	2.1	-0.5	0.6	-1.5	-0.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.4	1.1	-1.1	-0.4	-0.5	-0.7	0.1
Age at first live birth	0.4	0.7	1.8	-0.0	-0.1	1.3	-0.9	-0.9
Mean time to correctly identify matches	0.4	0.8	2.0	-1.4	1.2	0.3	0.7	0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	2.2	-0.3	-0.5	0.2	1.5	0.0
Ever taken oral contraceptive pill	0.4	0.4	0.9	0.2	0.2	-0.9	0.8	-0.8
Medication: Atorvastatin	0.4	0.5	0.9	0.8	-0.5	-0.9	-0.6	0.1
Leg fat percentage (left)	0.4	1.5	5.0	2.2	-0.5	0.4	-1.4	0.1
Risk taking	0.4	0.6	1.2	0.3	-1.1	0.2	-0.6	-1.1
Alcohol drinker status: Previous	0.4	0.5	1.4	0.2	0.7	1.2	0.7	-0.0
Rheumatoid Arthritis	0.3	0.4	0.8	0.9	0.2	0.3	0.5	0.9
BMI	0.3	1.8	3.6	1.7	-0.3	1.5	1.9	0.2
Systolic Blood Pressure	0.3	1.3	2.9	-0.7	0.1	1.1	-1.7	-1.4
Lung FVC	0.3	1.6	2.7	1.0	-1.5	-1.4	-1.6	-0.1
Average weekly fortified wine intake	0.3	0.4	0.8	-0.9	0.8	-0.3	-0.3	-0.5
Serious illness, injury or assault to yourself	0.3	0.4	0.7	0.1	0.5	-0.8	0.8	0.6
Body mass index (BMI)	0.3	1.4	2.5	1.3	-1.6	1.5	0.7	0.3
Nervous feelings	0.3	0.6	1.4	-0.9	-0.6	-0.2	-1.2	0.7
Had other major operations	0.3	0.4	1.2	-0.2	-0.6	0.3	-1.1	-0.5
Ever unenthusiastic/disinterested for a whole week	0.3	0.3	0.6	-0.8	0.0	-0.8	0.4	-0.5
Neuroticism score	0.3	0.6	1.9	-0.6	0.1	1.4	-0.3	-0.9
Arm fat mass (right)	0.3	1.3	3.9	-0.3	-0.4	1.4	-2.0	0.7
Pulse wave reflection index	0.3	0.4	0.7	0.7	-0.8	-0.1	-0.4	-0.7
Wheeze or whistling in the chest in last year	0.3	0.5	1.7	-0.2	-0.9	1.3	-0.1	0.4
Pulse rate, automated reading	0.3	1.0	2.5	1.6	-1.3	0.8	-0.1	0.4
Leg pain on walking	0.3	0.4	1.7	0.6	-0.2	1.3	-0.2	-0.2
Mood swings	0.3	0.5	1.1	-0.5	-0.5	1.0	0.7	0.6
Asthma (self-reported)	0.3	0.5	1.8	-1.4	0.2	0.3	0.8	0.3
Arm fat mass (left)	0.3	1.2	3.1	-0.4	-0.7	1.3	-1.7	0.8
Supplements: Fish oil (including cod liver oil)	0.3	0.4	1.4	0.1	1.2	-0.4	0.2	0.6
Irritability	0.3	0.5	1.0	-0.0	1.0	0.7	0.7	-0.8
Diastolic blood pressure, automated reading	0.3	1.0	3.2	-0.9	0.9	1.8	-0.0	-0.2
Depressed Affect (Nagel 2018)	0.2	0.4	1.5	0.3	-0.0	1.2	-0.2	0.5
Neuroticism (Nagel 2018)	0.2	0.4	1.3	0.5	0.3	1.1	0.6	-0.2
Prostate Cancer	0.2	0.3	0.6	0.2	-0.3	0.8	-0.5	0.6
Neuroticism (2016)	0.2	0.2	0.7	0.1	0.3	-0.4	0.9	-0.4
Triglycerides	0.2	0.3	1.1	-0.3	-0.6	1.0	0.2	0.0
Waist Hip Ratio (WHR)	0.2	0.9	3.1	-0.2	-0.9	-0.4	-1.8	0.6
Respiratory disease	0.2	0.5	1.2	-1.0	0.2	0.6	0.2	1.1
Chronotype (morning person)	0.2	0.4	1.9	1.4	0.1	0.1	-0.6	0.3
Other serious medical condition/disability diagnosed by doctor	0.2	0.3	0.9	0.0	-0.6	-0.1	0.0	-1.0
Current tobacco smoking	0.2	0.3	0.8	0.0	-0.9	-0.8	0.1	0.3
Maternal smoking around birth	0.2	0.2	0.4	0.5	0.6	-0.7	-0.2	0.2
Fed-up feelings	0.2	0.4	1.3	0.0	-1.1	0.4	0.5	-0.1
Mouth/teeth dental problems	0.2	0.3	0.9	-0.2	-0.8	0.1	-1.0	-0.1
Worrier / anxious feelings	0.2	0.4	1.2	-0.1	1.1	-0.3	-0.3	0.7
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.0	-0.7	0.1	-1.0	0.1	-0.6
Asthma	0.2	0.5	1.8	-1.3	0.3	0.4	0.5	0.2
Number of full brothers	0.2	0.2	0.9	0.2	-0.2	-0.0	0.1	0.9
Qualifications: College or University degree	0.2	0.6	1.8	-0.8	-0.5	1.3	0.6	-0.1
Neck or shoulder pain in last month	0.2	0.3	1.4	0.3	-1.2	-0.2	-0.1	-0.2
Smoking status: Current	0.2	0.3	1.1	-0.0	-0.6	-1.0	0.1	0.4
Tinnitus: Yes, now most or all of the time	0.2	0.3	1.2	0.4	0.1	-0.1	-0.1	-1.1
Worry (Nagel 2018)	0.1	0.3	1.1	0.3	-0.3	0.4	-0.4	-1.0
Blood Eosinophil Count	0.1	1.1	1.9	-1.4	1.1	-0.9	0.4	1.3
Blood Red Count	0.1	1.2	4.6	1.1	0.2	-2.1	0.3	0.6
Blood White Count	0.1	0.5	1.1	-0.3	0.8	0.5	-0.6	1.0
Tanning	0.1	1.6	3.7	0.2	0.7	1.5	1.9	-1.1
Average weekly spirits intake	0.1	0.1	0.4	-0.6	-0.2	0.1	-0.0	-0.2
Arm fat percentage (right)	0.1	0.3	0.9	0.9	-0.1	0.7	-0.1	0.3
Time employed in main current job	0.1	0.2	0.3	0.4	-0.2	-0.5	-0.4	-0.4
Arm fat percentage (left)	0.1	0.6	1.8	1.3	-0.7	0.7	-0.2	-0.0
Handedness (chirality/laterality): Left-handed	0.1	0.1	0.6	-0.1	-0.1	0.3	0.0	0.8
Fractured/broken bones in last 5 years	0.1	0.2	0.6	-0.4	-0.0	-0.1	0.0	0.8
Hair Pigment	0.0	0.8	1.8	-1.1	1.4	-0.6	-0.7	-0.3

Hub : Genes

HAPLN3

Models

Trait associations