Hub : Genes

ISG20

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Artery Tibial 0.1270 0.0557 8.8e-03 0.006 NA 0.023 NA 0.020 1.1e-01 NA 6.0e-03 NA 9.6e-03
2 GTEx Breast Mammary Tissue 0.1730 0.0680 8.5e-03 0.040 NA 0.070 NA 0.067 3.9e-03 NA 1.9e-04 NA 2.5e-04
3 GTEx Breast Mammary Tissue (Male) 0.0829 0.0855 2.1e-01 -0.008 NA 0.077 NA 0.124 5.2e-01 NA 7.5e-03 NA 8.7e-04
4 GTEx Breast Mammary Tissue (Female) 0.1726 0.0865 4.3e-02 0.011 NA -0.009 NA 0.016 1.5e-01 NA 7.2e-01 NA 1.1e-01
5 GTEx Testis 0.3910 0.0900 2.8e-05 0.230 NA 0.264 NA 0.220 1.4e-10 NA 4.0e-12 NA 3.8e-10
6 GTEx Whole Blood 0.1290 0.0470 5.8e-03 0.111 NA 0.080 NA 0.107 2.3e-10 NA 7.9e-08 NA 4.9e-10
7 NTR Blood 0.0546 0.0146 4.6e-06 0.013 0.020 0.029 0.023 0.032 3.9e-05 4.0e-07 7.8e-10 4.5e-08 1.3e-10
8 YFS Blood 0.2735 0.0310 0.0e+00 0.166 0.187 0.222 0.210 0.228 6.8e-52 6.1e-59 6.2e-71 7.8e-67 5.9e-73
9 TCGA Kidney Renal Clear Cell Carcinoma 0.0309 0.0173 7.9e-03 0.010 0.019 0.017 NA 0.012 2.2e-02 3.0e-03 4.3e-03 NA 1.4e-02
10 TCGA Pheochromocytoma and Paraganglioma 0.1900 0.0760 3.9e-05 0.154 0.102 0.105 NA 0.117 1.1e-06 7.6e-05 6.0e-05 NA 2.1e-05
11 TCGA Skin Cutaneous Melanoma 0.2740 0.1160 6.5e-03 0.166 0.098 0.142 NA 0.124 3.3e-05 1.4e-03 1.3e-04 NA 3.3e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7 8 9 10 11
Bipolar Disorder (2018) 0.2 0.3 1.3 0.4 -0.3 0.0 0.4 -0.9 0.7 -0.1 0.2 0.0 1.1 0.9
Bipolar Disorder or Schizophrenia 0.8 2.0 7.0 -0.2 -2.1 0.0 -0.8 -2.6 -1.6 -1.1 -1.6 -1.6 -0.3 -0.7
Depressed Affect (Nagel 2018) 0.2 0.4 1.0 0.6 -1.0 0.0 -0.5 -0.8 -0.3 0.6 0.0 -1.0 -0.4 -0.8
Depression (Nagel 2018) 0.4 0.6 1.7 0.6 -1.2 0.0 0.7 -0.8 -0.4 0.2 0.0 0.4 1.3 1.2
Intelligence (Savage-Jansen 2018) 0.6 1.8 5.3 -1.7 1.1 0.0 -1.6 0.5 0.8 1.2 1.0 -2.3 -1.6 -1.5
Neuroticism (Nagel 2018) 0.2 0.4 2.4 0.6 0.2 0.0 0.2 -0.3 0.3 1.6 0.9 -0.8 0.3 -0.3
Schizophrenia (2018) 1.6 3.4 7.1 -0.5 -2.3 0.0 -1.4 -2.7 -2.7 -1.4 -2.1 -2.1 -1.3 -1.6
Schizophrenia vs Biploar Disorder 1.2 1.5 3.9 0.5 -1.6 0.0 -1.6 -2.0 -1.4 -1.2 -1.3 0.3 -0.9 -1.3
Worry (Nagel 2018) 0.2 0.5 2.1 0.7 -0.5 0.0 -0.1 0.9 0.3 1.5 0.9 -1.0 0.3 -0.2
Alzheimer’s Disease (in mother) 0.7 0.8 2.4 0.8 1.1 0.5 0.9 1.6 -0.5 -0.4 -0.6 1.2 0.7 -0.9
Alzheimer’s Disease (in father) 0.8 0.9 5.9 0.2 -1.4 -2.4 0.8 -0.2 0.6 0.3 0.2 -0.4 -0.3 -0.3
Alzheimer’s Disease (including proxy) 0.2 0.4 1.4 0.4 0.0 -1.0 0.8 -0.3 -0.5 -0.1 -0.5 0.2 -0.2 -1.2
Crohns Disease (2017) 0.6 1.4 4.3 -0.1 0.3 -0.5 0.3 -0.1 1.4 0.7 1.1 1.7 2.0 2.1
Irritable Bowel Disease (IBD) 0.3 0.6 2.3 -0.4 -0.2 -0.9 0.3 -0.9 0.4 -0.5 0.2 1.1 1.1 1.5
Ulcerative Colitis (UC) 0.4 0.8 1.9 -1.0 -0.2 -1.1 0.3 -1.2 -1.0 -1.4 -1.0 -0.6 -0.9 -0.4
Major Depression (MDD) 0.9 1.1 5.1 1.5 -0.2 0.0 0.5 2.3 1.4 1.0 1.1 0.8 0.2 0.1
Reaction Time 0.3 0.6 1.6 -0.2 -0.8 0.1 -1.2 1.3 0.7 0.9 0.9 0.2 0.0 0.1
Verbal and Numeric Reasoning (VNR) 0.2 0.5 1.2 -1.0 -0.5 0.0 -0.6 -0.6 0.6 1.1 1.1 -0.7 -0.0 0.4
Breast Cancer 0.5 1.2 2.9 0.1 -1.7 -1.6 -0.8 -1.2 -0.3 -0.3 -0.3 -1.4 -1.6 -0.7
Ovarian Cancer 1.3 1.8 4.7 -2.0 -1.6 0.2 -1.4 -2.2 -0.2 0.9 0.6 -2.2 -0.3 0.5
Prostate Cancer 0.7 0.9 2.5 -0.4 -0.3 0.1 0.9 -0.5 -0.9 -1.6 -1.4 -0.9 -1.2 -1.0
Age at First Birth 0.4 0.5 1.3 -0.5 0.7 1.1 0.1 1.0 -0.0 -0.7 -0.4 -1.0 -0.7 -0.6
Bipolar Disorder (2011) 0.1 0.1 1.5 0.0 0.0 0.0 0.0 0.0 0.0 0.0 -1.2 0.0 0.0 0.0
Body Mass Index (BMI) (2010) 0.4 0.6 1.6 0.5 0.0 0.0 1.1 -1.3 -1.1 -0.0 -0.6 -0.3 -0.9 -1.0
Coronary Artery Disease (CAD) 0.3 0.3 0.6 -0.3 -0.8 0.0 0.5 -0.8 -0.3 -0.6 -0.5 0.3 -0.7 -0.8
Crohns Disease (2012) 1.7 2.7 8.6 1.9 -1.2 0.0 -0.8 -1.4 1.6 0.8 1.2 2.9 2.5 1.7
Mean Putamen Volume 0.6 0.7 1.8 -0.8 -1.3 0.0 -1.1 1.4 0.3 -0.1 0.1 -0.3 -0.9 -0.9
Fasting Glucose 0.9 1.0 2.7 -0.2 0.4 0.0 -0.0 -1.1 1.6 0.8 0.9 -0.8 -1.7 -1.6
HbA1C 0.9 1.0 3.5 1.9 -0.6 -0.9 1.6 -0.6 0.9 -0.3 -0.1 0.2 -1.0 -1.2
HDL Cholesterol 1.2 2.1 6.4 -1.0 -0.5 0.0 0.9 -1.0 -1.7 -2.5 -2.4 -1.0 -1.4 -1.3
LDL Cholesterol 0.7 1.1 3.2 0.1 1.0 0.0 -0.7 1.4 1.5 1.7 1.8 0.3 -0.5 -0.7
Lupus 1.3 1.9 5.0 -0.5 -0.9 -2.2 -2.1 -1.8 1.3 1.1 1.0 -1.6 0.2 1.0
Neuroticism (2016) 0.6 0.9 3.9 -1.0 1.3 -0.2 2.0 0.3 1.0 0.9 1.0 -0.6 -0.7 -0.4
Primary Biliary Cirrhosis 0.4 0.6 1.5 0.9 -0.5 0.0 -0.2 -0.5 1.2 0.6 0.6 0.8 1.2 0.9
Rheumatoid Arthritis 1.6 2.2 6.4 1.3 0.2 0.0 0.4 -1.0 2.0 2.5 2.3 1.4 1.4 1.4
Schizophrenia (2014) 1.9 4.2 13.0 0.4 -3.1 0.0 -1.5 -3.6 -2.3 -2.0 -2.3 -1.1 -1.4 -1.8
Triglycerides 0.1 0.2 1.0 0.5 1.0 0.0 0.6 0.3 0.1 0.7 0.5 0.3 -0.2 -0.3
Type 2 Diabetes (T2D) (2012) 0.4 0.4 2.0 0.2 -1.4 0.0 -1.2 -0.8 0.2 -0.3 -0.1 0.3 0.2 0.2
Ulcerative Colitis 0.3 0.5 2.8 -0.0 -1.7 0.0 -0.1 -1.5 0.1 -0.1 0.1 0.5 0.1 0.1
Blood Eosinophil Count 0.2 1.5 4.5 0.8 -0.1 0.8 -1.5 2.0 -0.8 -0.7 -0.8 -1.1 -1.4 -2.1
Blood Platelet Count 0.3 3.0 9.5 -0.7 1.0 -1.2 -0.2 0.6 1.9 2.8 3.1 0.4 1.5 2.4
Blood Red Count 0.1 1.2 4.2 1.9 0.0 0.3 0.3 0.7 2.0 1.0 1.1 -0.3 -0.4 -1.4
Blood White Count 0.2 1.7 8.0 0.1 2.8 0.8 1.4 1.9 1.4 0.8 0.7 0.4 0.4 -1.3
Heel T-Score 0.5 4.3 9.0 0.8 -1.9 0.6 -0.4 3.0 -2.1 -2.6 -2.5 -1.6 -2.3 -3.0
BMI 0.1 0.7 2.6 1.4 0.6 -0.5 1.6 0.7 -0.4 -0.4 -0.4 0.5 0.6 1.0
Height 0.4 8.6 41.7 3.7 0.2 -2.7 1.0 -6.5 3.6 0.7 1.1 1.3 2.7 2.7
Waist Hip Ratio (WHR) 0.1 0.5 2.5 -0.1 1.6 0.1 1.0 1.0 0.0 -0.0 0.2 0.2 -0.6 -0.6
Systolic Blood Pressure 0.4 1.9 8.1 1.1 2.3 0.7 2.9 1.7 0.5 -0.1 0.0 1.7 -0.1 -0.1
Smoking Status 0.3 0.8 2.0 -0.6 -0.8 -1.2 -0.5 -1.4 1.2 0.7 1.0 0.3 0.3 0.8
Allergy or Eczema 0.7 1.7 3.7 -1.1 0.1 -1.9 0.3 -1.4 -0.6 -1.2 -1.0 -1.9 -1.7 -1.8
Cardiovascular Disease 0.6 1.9 11.1 -0.2 2.9 -0.5 3.3 -0.4 0.1 0.4 0.2 -0.1 -0.8 -0.3
Hypothyroidism (self reported) 0.6 1.4 5.7 0.7 0.7 0.1 0.6 2.4 1.1 0.6 0.7 1.6 1.4 1.2
Respiratory disease 0.3 0.7 3.3 -1.1 1.2 -1.8 0.2 -0.1 0.1 -0.8 -0.7 -0.6 -0.2 -0.8
Type 2 Diabetes (T2D) (2018) 0.3 0.6 2.3 1.2 -0.7 0.3 -0.9 1.5 0.7 -0.1 -0.1 0.7 0.5 -0.8
Lung FEV1/FVC ratio 0.2 1.2 5.9 -0.4 1.2 -1.9 2.4 -0.7 -0.6 -0.7 -0.5 -0.7 -0.2 -0.3
Lung FVC 0.2 1.2 7.3 0.5 0.7 0.2 0.7 2.7 -1.9 -0.1 -0.6 -0.0 -0.3 -0.7
Neuroticism 0.3 0.7 3.2 0.2 -0.3 0.4 -0.2 -0.7 -0.3 1.4 0.6 -1.8 -0.8 -0.8
Chronotype (morning person) 0.1 0.3 1.5 0.6 -1.2 0.4 -0.4 0.3 -0.9 0.1 0.0 0.7 0.1 -0.1
Hair Pigment 0.1 2.6 7.0 -0.4 -0.0 0.0 -0.5 1.9 1.8 0.7 1.6 2.6 2.3 2.5
Tanning 0.3 3.3 9.0 -0.5 -0.6 0.5 -0.2 -0.1 -2.3 -2.0 -2.2 -2.6 -3.0 -2.4
Hand grip strength (left) 0.7 1.8 5.4 2.3 0.2 1.4 1.7 0.0 -0.1 -0.0 -0.2 1.9 2.2 0.9
Number of treatments/medications taken 0.3 0.6 2.1 0.8 1.2 -0.0 1.3 1.5 -0.0 0.4 0.4 0.6 -0.2 0.4
Average weekly spirits intake 0.5 0.6 2.0 1.4 -1.1 1.3 0.6 -0.7 -0.1 -0.5 -0.2 0.4 0.5 0.9
Sensitivity / hurt feelings 2.0 3.5 8.4 1.3 2.5 -0.0 1.0 1.2 2.6 2.9 2.8 0.4 1.3 1.6
Frequency of depressed mood in last 2 weeks 0.5 0.8 2.0 1.2 -0.8 -0.1 1.1 -0.6 0.6 0.5 0.4 0.4 1.3 1.4
Hearing difficulty/problems: Yes 1.5 2.3 6.6 -1.1 0.2 -0.2 1.4 -2.2 -2.3 -2.2 -2.6 -0.4 -0.1 -0.1
Relative age of first facial hair 1.1 2.2 12.3 0.3 0.3 -3.5 -0.1 -2.4 -1.2 -0.8 -1.2 -1.0 -0.6 -1.0
Other serious medical condition/disability diagnosed by doctor 0.5 0.6 2.4 0.4 0.7 0.1 0.1 0.3 1.5 1.0 1.2 0.3 -0.7 -0.8
Ever used hormone-replacement therapy (HRT) 1.3 1.6 4.5 0.2 -1.1 -1.2 0.5 1.3 -1.9 -2.1 -1.9 -0.3 -1.0 -0.7
Ever had hysterectomy (womb removed) 1.1 1.2 3.4 1.3 -0.3 0.5 -0.3 -1.0 -1.6 -1.8 -1.8 -0.1 -0.5 -0.9
Systolic blood pressure, automated reading 0.4 1.1 7.0 0.3 0.9 2.6 1.6 1.2 0.0 0.1 0.3 0.4 -0.3 0.3
Eye problems/disorders: Diabetes related eye disease 0.8 0.9 3.8 -0.3 -0.7 -0.2 -0.8 -1.9 -1.0 0.0 -0.7 -0.8 -1.1 -1.2
Angina 0.5 0.6 2.3 0.1 0.6 1.0 -0.2 0.2 -0.5 -0.3 -0.5 -0.7 -1.5 -1.4
Medication for hormone replacement therapy 1.5 1.6 3.6 0.1 -0.3 -1.3 -0.4 0.1 -1.9 -1.8 -1.7 -0.4 -1.7 -1.8
Vitamin and mineral supplements 1.0 1.4 4.5 1.0 -0.1 1.3 0.4 1.0 2.1 0.1 0.9 1.7 1.6 0.8
Supplements: Zinc 1.2 1.3 4.1 -2.0 -0.6 0.2 -0.8 0.2 -1.6 -1.1 -1.2 -1.5 -1.0 -0.7
Medication: Co-codamol 0.7 0.8 3.4 -0.7 0.3 -1.0 0.7 1.8 -0.3 -1.1 -1.1 -0.4 -0.2 -0.6
Medication: Metformin 0.3 0.4 0.9 1.0 0.0 0.1 0.7 -0.0 0.8 0.7 0.8 0.9 0.6 0.6
Diabetes (father) 0.2 0.2 0.9 -0.0 -0.4 0.6 -0.1 -0.5 -0.4 -0.2 -0.0 -0.8 -0.9 0.1
Diabetes (mother) 0.9 1.1 7.5 -0.8 1.4 0.9 2.7 0.4 0.2 0.8 0.6 -0.4 -0.1 0.5
Severe depression (siblings) 0.8 0.8 1.9 -1.2 0.9 0.6 0.2 0.8 -0.3 1.3 0.7 -0.8 1.1 1.4
Pack years adult smoking proportion 1.0 1.6 5.8 1.8 0.9 -1.2 0.5 -2.4 0.1 1.0 0.6 1.4 1.1 1.1
Impedance of leg (right) 0.1 0.5 1.5 -1.2 -0.6 0.2 -1.1 -0.0 -1.2 -0.8 -0.6 0.3 -0.4 -0.6
Leg fat-free mass (left) 0.7 3.5 6.2 2.4 1.5 -1.8 2.5 -2.1 2.4 1.4 1.4 1.1 1.7 1.6
Trunk fat percentage 0.3 1.4 6.3 1.1 1.6 -1.2 2.5 -0.3 0.2 0.2 0.4 1.0 0.6 1.4
Hand grip strength (right) 0.2 0.6 3.5 1.0 0.1 1.9 1.0 -0.4 -0.6 0.1 -0.3 0.0 0.8 0.0
Townsend deprivation index at recruitment 0.7 1.0 4.2 2.1 0.9 -1.6 -0.7 -0.3 0.1 1.4 0.9 0.5 0.5 0.1
Current tobacco smoking 0.3 0.6 1.5 0.7 -0.1 -0.6 1.2 -0.4 1.2 -0.4 -0.1 0.8 1.1 -0.3
Average weekly fortified wine intake 0.5 0.6 1.5 0.4 -0.2 -0.2 -0.4 0.4 0.8 1.0 1.2 1.1 1.0 0.9
Maternal smoking around birth 0.8 1.2 4.9 -2.2 -1.6 1.6 -0.9 0.0 -0.6 -1.1 -0.8 -0.8 -0.0 0.2
Fed-up feelings 0.2 0.3 1.4 1.2 -0.0 -0.1 0.5 0.1 0.7 0.8 0.6 0.3 0.6 0.1
Frequency of unenthusiasm / disinterest in last 2 weeks 0.8 1.0 3.0 -0.0 -1.5 -0.9 -0.8 -1.7 -1.2 -0.1 -0.5 0.4 1.2 1.1
Relative age voice broke 0.6 0.9 3.8 -0.1 0.3 -1.9 -0.0 -0.1 -0.2 -0.0 -0.4 -1.9 -0.9 -1.1
Taking other prescription medications 1.2 1.8 5.0 1.3 0.8 0.5 1.4 2.0 0.2 -0.1 0.2 1.4 2.2 2.0
Age when periods started (menarche) 0.4 1.1 4.2 0.7 0.6 -2.0 0.6 -0.0 -0.3 -0.7 -0.5 -0.5 -1.0 -2.0
Bilateral oophorectomy (both ovaries removed) 1.5 1.7 4.0 0.8 -2.0 0.1 -1.4 -0.8 -1.9 -1.9 -1.6 1.4 0.1 -0.1
Heel bone mineral density (BMD) T-score, automated (left) 1.3 2.8 5.8 0.7 -2.0 -0.0 -0.7 2.4 -1.8 -2.3 -2.2 -0.5 -1.4 -2.2
Tinnitus: Yes, but not now, but have in the past 1.2 1.3 5.9 -2.4 -1.3 0.3 -0.6 0.1 -1.0 -0.8 -0.8 -1.4 -1.3 -0.6
Qualifications: CSEs or equivalent 0.4 0.6 2.0 -0.1 0.7 -0.7 1.4 0.3 0.5 -0.2 -0.1 -0.3 -0.9 -1.4
Serious illness, injury or assault to yourself 0.4 0.5 2.0 0.7 0.8 0.6 -0.3 0.2 0.7 0.3 0.4 -0.5 -1.4 -1.0
High blood pressure 0.7 2.0 11.6 -0.4 2.5 0.6 3.4 -0.9 0.4 0.9 0.9 0.2 -1.1 0.2
Hayfever, allergic rhinitis or eczema 0.6 1.2 3.5 -0.7 -0.5 -1.9 -0.4 -1.0 -0.9 -1.2 -1.0 -1.4 -1.3 -0.9
Multivitamins +/- minerals 0.7 0.9 2.7 -0.1 -0.4 -1.1 -0.3 -0.4 -1.7 -0.3 -0.8 -1.5 -1.3 -0.8
Stomach or abdominal pain in last month 0.3 0.3 0.8 0.3 0.5 -0.4 0.5 -0.7 0.9 0.5 0.8 0.2 0.7 0.6
Supplements: Glucosamine 0.4 0.6 1.8 -0.2 0.1 0.2 0.0 -0.2 1.3 1.1 1.3 0.1 0.1 1.1
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 3.6 -1.9 0.8 1.2 -0.0 0.9 -0.9 -1.3 -1.0 -0.9 -1.3 -0.9
Medication: Atenolol 0.2 0.2 0.5 -0.7 -0.3 0.2 0.4 0.7 -0.3 0.5 0.2 0.3 0.2 0.7
Medication: Levothyroxine sodium 0.8 1.3 8.3 -0.2 1.0 1.2 1.5 2.9 -0.0 -0.9 -0.6 0.4 0.0 0.0
Sitting height 1.1 7.8 28.6 1.2 0.6 -1.0 1.6 -4.6 5.3 2.6 3.2 0.8 2.4 2.6
Chronic bronchitis/emphysema (father) 1.1 1.2 3.7 -1.9 0.6 0.8 0.8 1.4 -1.0 -0.5 -0.8 -1.6 -1.1 -0.8
High blood pressure (mother) 0.5 0.7 5.6 2.4 0.1 -0.1 0.5 0.1 0.4 0.5 0.1 1.1 0.1 -0.8
Body mass index (BMI) 0.3 1.3 3.9 1.3 1.1 -0.3 2.0 1.6 0.3 0.1 0.4 1.0 0.8 1.5
Impedance of leg (left) 0.1 0.6 2.7 -1.6 -0.4 0.6 -1.0 -0.4 -1.1 -0.5 -0.4 0.1 -0.4 -0.3
Leg predicted mass (left) 0.6 3.4 5.8 2.4 1.5 -1.7 2.4 -2.1 2.4 1.4 1.4 1.1 1.7 1.7
Trunk fat mass 0.5 2.1 8.0 1.2 2.0 -1.4 2.8 -1.0 0.8 0.6 0.8 0.9 0.9 1.7
Waist circumference 0.5 1.8 6.8 1.3 1.9 -0.7 2.6 0.5 1.3 0.7 1.2 0.9 0.5 1.4
Number of incorrect matches in round 0.5 0.9 3.1 -0.0 -0.2 0.0 0.3 -0.1 -0.6 -1.2 -1.3 -0.8 -1.5 -1.8
Past tobacco smoking 0.5 0.9 4.3 0.8 0.6 1.7 2.1 0.8 -0.6 -0.1 -0.4 0.1 0.1 -0.9
Alcohol usually taken with meals 0.6 0.9 3.5 0.3 1.8 0.2 -0.4 0.3 0.7 1.9 1.5 -0.1 0.7 0.0
Nervous feelings 0.5 0.9 4.2 -0.4 0.8 0.3 1.0 -0.2 0.5 2.0 1.3 -1.3 0.3 -0.1
Frequency of tenseness / restlessness in last 2 weeks 0.7 1.0 6.3 -0.1 -1.1 -0.9 -0.4 -2.5 -1.5 0.0 -0.4 -0.4 0.1 0.5
Hearing difficulty/problems with background noise 0.7 1.2 4.0 -0.8 0.5 0.0 0.9 -1.0 -1.4 -2.0 -2.0 0.4 0.5 0.4
Hair/balding pattern: Pattern 2 1.1 1.4 4.8 -0.3 1.0 1.2 0.7 2.2 0.4 0.1 0.7 1.8 1.1 1.7
Had menopause 1.8 2.2 7.0 -1.5 1.1 2.6 1.7 0.9 -0.8 -1.3 -1.4 -1.7 -1.2 -1.2
Had other major operations 1.1 1.4 8.8 3.0 -0.8 1.9 0.3 0.2 -0.3 -0.7 -0.3 1.1 0.5 0.1
Forced vital capacity (FVC) 0.6 2.2 6.8 2.4 1.0 -0.9 1.5 -0.2 -0.3 0.2 -0.2 2.3 2.6 1.4
Heel bone mineral density (BMD) T-score, automated (right) 1.3 2.9 7.9 0.4 -2.4 -0.2 -1.2 2.8 -1.8 -1.9 -1.9 0.0 -1.3 -2.1
Ever unenthusiastic/disinterested for a whole week 1.0 1.3 4.8 2.0 -2.2 -1.2 -1.8 -0.2 -0.5 -0.1 -0.3 0.1 -0.3 -0.6
Qualifications: None of the above 0.2 0.5 1.6 0.0 0.6 -0.4 0.7 0.7 -1.0 -1.3 -0.9 0.5 -0.1 0.2
Financial difficulties in last 2 years 1.8 2.4 8.6 0.9 -1.4 -0.6 -1.9 0.2 0.8 1.1 1.1 1.5 2.9 2.3
Mouth/teeth dental problems 0.8 1.3 5.2 1.8 -0.0 1.6 0.7 1.0 0.4 -0.6 -0.1 2.3 0.9 0.4
Heart attack 1.8 2.3 5.5 2.3 -0.1 1.0 2.0 -1.2 -1.3 -1.2 -1.5 -0.8 -1.9 -2.1
Allergy 0.8 1.8 5.0 0.8 -0.7 2.2 -0.4 0.4 1.7 1.8 1.8 1.6 1.0 1.1
Pain all over the body in last month 0.8 0.9 2.9 -0.1 0.0 0.8 -0.7 0.9 -0.7 -0.9 -1.0 -0.8 -1.5 -1.7
Diabetes (self-reported) 0.4 0.7 1.9 1.3 -0.7 -1.4 -0.9 0.7 0.6 0.5 0.4 0.8 0.6 -0.0
Hayfever/allergic rhinitis (self-reported) 0.8 1.0 4.5 -2.1 -0.0 -0.2 -0.7 0.6 0.8 0.2 0.4 -1.9 -1.0 -0.0
Medication: Ramipril 1.0 1.3 2.9 1.7 0.5 -0.6 1.6 -1.6 0.6 1.2 0.9 1.2 0.9 0.8
Medication: Simvastatin 0.7 1.0 4.4 0.8 0.8 2.1 0.9 0.2 0.2 -0.3 -0.2 0.1 -1.4 -1.6
Fluid intelligence score 0.1 0.3 1.3 -0.4 -1.2 0.9 -0.8 -0.1 0.0 0.2 0.2 -0.2 -0.1 -0.0
Illnesses of siblings 0.3 0.4 2.9 0.4 0.0 -0.9 0.2 -1.7 0.0 -0.2 0.1 0.4 0.4 0.6
Neuroticism score 0.5 1.1 5.7 0.8 0.5 -0.7 0.3 -0.5 0.9 2.4 1.7 -0.8 0.0 0.1
Weight 0.6 3.0 8.1 2.0 1.8 -1.1 2.8 -0.9 1.9 1.0 1.4 1.3 1.6 2.2
Impedance of arm (right) 0.3 1.2 3.1 -0.7 -0.1 -1.2 -0.5 -0.7 -1.2 -1.2 -1.1 -0.9 -1.8 -1.6
Arm fat percentage (right) 0.2 0.7 2.5 0.7 1.1 -1.4 1.6 0.7 -0.3 -0.4 -0.1 0.6 0.2 1.0
Trunk fat-free mass 0.4 2.4 6.7 1.4 0.7 -1.1 1.2 -2.6 2.5 1.2 1.2 0.6 1.7 1.6
Hip circumference 0.9 4.1 9.1 1.8 1.8 -1.4 2.4 -0.9 2.5 1.6 2.0 1.8 2.1 3.0
Time employed in main current job 1.3 1.5 3.2 -0.9 0.1 1.6 -0.7 1.8 1.8 1.4 1.6 -1.2 -0.5 -0.3
Alcohol intake versus 10 years previously 0.7 1.0 3.0 -1.4 0.3 0.0 -0.3 0.5 -1.7 0.1 -0.4 -1.6 -1.6 -0.8
Father’s age at death 0.5 0.7 2.6 -0.7 -0.9 0.2 -0.4 -0.8 -0.8 0.4 0.1 -1.6 -1.2 -0.6
Worrier / anxious feelings 0.8 1.5 6.2 0.4 1.2 0.8 0.5 0.1 1.8 2.5 1.9 -0.6 -0.2 -0.5
Frequency of tiredness / lethargy in last 2 weeks 1.3 2.1 6.2 -0.0 1.0 -1.0 1.4 -1.2 -1.6 -0.9 -1.2 -1.8 -2.5 -1.7
Falls in the last year 0.7 0.9 4.3 -1.1 -0.5 -0.1 -2.1 -0.5 0.5 0.3 0.3 -1.4 -1.0 -0.9
Hair/balding pattern: Pattern 3 0.6 0.9 2.7 1.5 -0.4 0.2 1.3 -1.4 0.1 -0.4 -0.6 -0.2 -0.7 -1.7
Number of live births 1.1 1.6 8.0 -0.2 2.2 -1.4 2.8 -0.2 -0.6 -0.4 -0.2 0.3 0.5 1.0
Forced expiratory volume in 1-second (FEV1) 0.7 2.3 5.9 2.3 1.2 -0.8 2.1 -0.1 -0.3 0.5 0.0 2.3 2.4 1.3
Pulse rate 0.6 1.0 3.8 -1.1 1.3 -2.0 1.2 -1.2 0.5 0.4 0.4 -0.7 -0.4 -0.1
Happiness 0.7 0.8 2.7 1.6 -1.1 -1.3 -0.4 0.1 1.2 0.8 0.9 0.4 -0.5 -0.3
Noisy workplace 1.1 1.3 3.5 -0.3 -0.1 0.2 1.1 0.0 -0.7 -1.6 -1.3 -1.3 -1.8 -1.9
Qualifications: A levels/AS levels or equivalent 0.2 0.4 1.6 0.2 -0.4 0.5 -0.7 -1.2 -0.7 0.1 -0.1 -0.1 0.8 0.4
Serious illness, injury or assault of a close relative in last 2 years 2.1 2.5 7.8 0.1 -1.8 -2.0 -2.0 0.7 -0.1 0.3 0.2 1.8 2.8 2.0
Mouth/teeth dental problems: Dentures 0.3 0.6 1.8 -0.1 -0.3 -0.2 -0.8 -0.5 1.3 1.0 1.2 -0.3 0.4 0.8
Asthma 0.3 0.6 2.1 -0.6 0.9 -1.4 0.4 1.4 -0.2 -0.4 -0.2 -0.9 0.1 0.0
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.8 3.3 1.1 0.3 -0.9 0.5 -1.8 -0.4 1.1 0.4 -0.4 -1.0 -1.0
Medication: Cholesterol lowering 0.2 0.4 1.1 -0.5 0.8 1.0 1.0 -0.4 -0.3 0.3 0.1 -0.3 -0.4 0.4
Depression (self-reported) 1.0 1.2 3.9 2.0 -0.3 0.3 0.8 1.8 1.0 0.8 0.9 0.7 1.1 0.8
Medication: Lansoprazole 1.9 2.2 4.6 1.6 2.1 -1.3 1.2 1.0 1.5 2.1 2.1 1.3 0.7 0.4
Prospective memory result 0.5 0.6 2.9 -1.1 0.7 0.5 0.7 -0.5 -0.7 0.2 0.1 -0.1 0.9 1.7
Lung cancer (father) 0.9 1.0 4.5 -0.9 2.1 0.3 0.5 1.7 1.3 0.4 0.8 0.4 0.1 0.2
Illnesses of mother 0.5 0.6 1.7 -0.8 -0.4 -0.4 0.3 -1.1 -0.2 -0.9 -0.7 -1.3 -0.7 -1.0
Forced expiratory volume in 1-second (FEV1), Best measure 0.7 2.1 6.1 2.5 1.3 -0.5 1.9 -0.3 0.1 0.3 -0.0 2.3 2.1 1.1
Pulse wave Arterial Stiffness index 0.9 1.1 3.3 1.2 1.1 -0.7 0.6 -1.0 -0.0 0.5 0.4 1.8 1.0 1.7
Impedance of arm (left) 0.2 1.0 2.2 -0.2 0.0 -1.5 -0.5 -1.3 -1.2 -0.9 -0.9 -0.4 -1.1 -1.4
Arm fat mass (right) 0.4 1.5 4.9 1.5 1.2 -1.2 2.2 -0.1 0.7 0.2 0.5 1.2 1.2 1.8
Trunk predicted mass 0.5 2.6 7.0 1.3 0.8 -1.2 1.2 -2.6 2.6 1.4 1.4 0.6 1.7 1.7
Standing height 0.7 6.5 28.7 1.6 1.2 -2.1 1.7 -5.4 3.5 1.8 2.0 1.1 2.4 2.2
Length of working week for main job 0.5 0.6 2.7 1.0 0.2 -0.4 -0.1 -0.0 0.3 0.0 0.2 0.7 1.6 1.3
Exposure to tobacco smoke at home 0.8 0.9 3.9 -0.6 -0.8 -0.2 -0.4 -0.2 0.3 1.3 1.0 -2.0 -1.3 -0.4
Breastfed as a baby 0.4 0.5 1.3 0.7 0.8 -0.8 0.2 -0.2 0.6 0.4 0.3 1.1 1.1 0.9
Tense / ‘highly strung’ 0.8 1.4 3.1 1.1 0.8 -0.1 1.3 1.2 1.1 1.8 1.4 0.5 1.6 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.3 0.5 2.0 0.6 0.0 -1.4 -0.5 -0.4 -0.1 0.4 -0.2 -1.3 -0.1 -0.9
Hair/balding pattern: Pattern 4 0.6 1.5 4.9 -1.8 -0.5 -0.5 -0.5 -0.5 -1.5 -1.2 -1.6 -2.2 -1.1 -0.5
Birth weight of first child 0.5 1.0 3.2 0.5 -1.4 1.2 -1.8 -0.8 0.5 0.2 0.3 0.6 1.2 1.1
Peak expiratory flow (PEF) 0.5 1.1 3.5 0.7 0.4 0.7 1.9 -0.8 -1.8 -1.1 -1.5 0.5 0.4 -0.3
Pulse wave reflection index 0.9 1.1 5.6 2.4 -0.8 -0.2 -0.6 0.9 0.4 -0.6 -0.2 2.0 0.3 -0.1
Ever highly irritable/argumentative for 2 days 0.6 0.7 2.4 1.0 -0.4 0.4 1.0 0.4 -0.8 -0.5 -0.5 1.5 1.2 0.8
Loud music exposure frequency 0.4 0.4 2.2 1.5 -0.7 -1.1 -0.0 0.1 -0.3 0.4 0.1 0.6 0.3 -0.0
Qualifications: O levels/GCSEs or equivalent 0.3 0.4 0.9 0.7 -0.8 -0.2 -0.9 -0.9 0.2 -0.7 -0.6 0.7 0.7 0.1
Mouth/teeth dental problems: Bleeding gums 0.5 0.6 2.4 -1.4 0.4 -0.7 -0.3 -0.3 -0.5 0.2 -0.3 -1.6 -0.8 -0.9
Blood clot in the leg (DVT) 0.4 0.5 1.8 -0.1 1.0 -1.2 0.7 0.5 0.1 0.1 0.1 -1.3 -0.9 -0.1
Medication: Paracetamol 0.5 0.8 4.2 0.0 1.4 -2.0 0.8 -0.7 0.2 0.8 0.7 0.3 0.0 0.4
Headache pain in last month 2.0 3.4 10.9 -0.6 3.3 -1.9 1.2 -0.1 1.3 2.3 2.3 1.2 1.5 2.3
Medication for cholesterol, blood pressure or diabetes 0.5 0.9 1.9 0.5 -0.5 -0.5 -1.0 1.2 1.3 1.1 1.3 0.4 1.4 0.2
Glaucoma (self-reported) 0.3 0.3 1.2 0.9 -0.0 -0.6 -0.4 -1.1 0.7 0.1 0.0 0.1 -0.2 -0.8
Gout (self-reported) 0.8 1.1 4.8 0.7 2.2 -0.7 1.8 1.1 -0.2 0.1 -0.0 1.0 0.6 0.5
Hypothyroidism/myxoedema (self-reported) 0.4 0.8 4.4 0.5 0.7 -0.3 0.9 2.1 -0.0 -0.8 -0.7 1.0 0.3 -0.3
Medication: Amlodipine 0.6 0.8 2.1 -1.4 -0.8 1.1 -1.4 -0.8 -0.2 -0.4 -0.6 -0.3 -0.8 -1.0
Medication: Ventolin 100micrograms inhaler 0.5 0.7 2.8 -1.7 0.6 -1.1 0.4 -1.1 0.3 0.2 0.2 -1.3 0.2 0.1
Birth weight 0.2 0.3 1.5 1.0 -0.2 -1.2 -0.4 -0.4 -0.4 -0.4 -0.4 -0.0 -0.0 -0.4
Chronic bronchitis/emphysema (mother) 1.2 1.3 3.0 1.0 1.0 0.3 1.0 0.3 1.4 0.5 1.1 1.6 1.7 1.5
High blood pressure (siblings) 0.5 0.7 2.5 -0.7 0.3 1.1 0.0 0.4 0.6 1.1 0.5 -1.6 -0.9 -1.0
Forced vital capacity (FVC), Best measure 0.5 1.7 4.0 2.0 1.8 -0.2 2.0 -0.6 0.1 0.4 0.0 1.8 1.8 0.8
Body fat percentage 0.3 1.1 4.8 0.8 1.4 -1.1 2.2 0.2 0.0 0.2 0.4 0.9 0.6 1.6
Leg fat percentage (right) 0.2 0.8 2.9 0.1 0.8 -0.1 1.4 1.7 -0.1 0.2 0.5 0.8 0.4 1.6
Arm fat-free mass (right) 0.8 4.3 8.2 1.8 1.3 -0.3 2.5 -2.8 2.9 1.9 1.9 1.4 2.4 2.3
Exposure to tobacco smoke outside home 0.4 0.5 2.3 -0.3 -0.8 -0.7 -0.4 -1.5 0.1 0.7 0.7 -0.6 -0.7 0.7
Comparative body size at age 10 0.3 0.8 4.6 -0.0 0.5 -1.1 -0.0 2.1 0.1 0.6 0.8 0.6 0.7 0.8
Number of full brothers 1.3 1.6 5.0 2.0 1.8 0.2 2.2 0.0 0.8 0.4 0.5 1.4 1.4 0.8
Worry too long after embarrassment 0.7 1.2 3.6 -1.6 0.7 -0.5 0.3 -1.9 0.5 1.4 0.9 -1.8 -0.4 0.2
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.6 1.7 1.0 0.1 -1.0 0.7 0.1 0.5 -0.1 0.2 1.1 1.3 0.8
Wheeze or whistling in the chest in last year 1.1 2.0 4.3 -1.2 0.8 0.2 1.0 1.2 -1.7 -2.1 -2.0 -1.9 -1.1 -1.2
Number of children fathered 0.7 0.8 5.6 0.6 -0.6 -2.4 0.6 0.0 0.1 -0.9 -0.5 0.2 0.4 0.6
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.3 0.9 0.9 -0.5 0.3 0.0 0.5 0.3 0.8 0.9 0.5 -0.3 0.0
Age at first live birth 1.4 2.5 5.1 -1.6 -0.6 -0.7 -0.0 -1.6 -2.0 -1.8 -2.2 -2.3 -1.4 -1.7
Pulse wave peak to peak time 0.8 1.0 3.4 -1.4 -1.1 0.6 -0.4 0.4 0.1 -0.6 -0.4 -1.8 -0.9 -1.5
Health satisfaction 0.8 1.0 2.2 0.5 -0.2 -1.4 0.4 -1.0 1.1 1.4 1.5 0.8 0.8 1.1
Shortness of breath walking on level ground 0.3 0.3 1.2 -0.8 -0.7 -0.2 -0.2 -1.1 0.1 0.5 0.5 -0.4 0.0 0.9
Qualifications: College or University degree 0.5 1.6 7.3 1.0 0.3 -0.0 -0.7 -0.8 1.7 2.7 2.2 -0.5 0.6 0.1
Eye problems/disorders: None of the above 0.5 0.6 1.6 1.3 -0.8 -1.0 -1.1 -0.4 0.6 -0.3 -0.2 1.1 0.7 -0.0
Mouth/teeth dental problems: Loose teeth 0.5 0.6 1.8 -0.8 1.4 -0.8 0.6 0.1 -0.2 0.2 -0.0 -1.1 -0.9 -1.1
Emphysema/chronic bronchitis 0.6 0.7 2.5 -0.6 1.3 -0.7 1.1 -1.6 -0.9 0.3 0.1 -0.1 0.4 0.7
Medication for pain relief, constipation, heartburn 0.6 1.0 3.2 -1.7 -1.6 0.5 -1.8 0.6 0.1 -1.0 -0.6 -0.6 -0.0 0.2
Neck or shoulder pain in last month 0.9 1.2 4.1 -0.4 1.3 0.8 2.0 0.4 -0.9 -1.6 -1.6 -0.8 -0.3 -0.4
Medication: Blood pressure 0.7 1.3 4.2 -0.3 -0.1 -0.3 0.3 -1.1 -1.6 -1.4 -1.6 -1.0 -2.1 -0.8
Angina (self-reported) 0.3 0.4 1.3 0.1 0.7 0.7 -0.0 0.4 -0.1 0.0 -0.2 -0.5 -1.2 -1.1
Migraine (self-reported) 0.8 1.0 3.0 -0.6 1.7 0.3 1.1 -0.1 -1.6 -1.2 -1.3 0.9 0.3 -0.2
Medication: Ibuprofen 0.8 0.9 3.5 1.3 -0.2 -0.6 -0.1 -1.9 0.1 1.3 0.8 0.2 -1.0 -1.1
Medication: Allopurinol 0.4 0.5 1.6 -0.0 1.0 -1.2 0.4 0.7 -0.0 -0.2 -0.3 1.3 0.7 0.3
Medication: Omeprazole 2.6 3.1 6.3 2.1 0.7 0.2 2.2 0.2 1.7 1.7 1.7 2.2 2.5 2.3
Medication: Seretide 50 evohaler 0.4 0.5 1.8 0.0 0.7 -1.3 1.1 -0.9 0.0 0.5 0.4 0.3 0.1 0.5
Mean time to correctly identify matches 0.3 0.6 3.3 -0.2 -1.4 0.3 -1.8 1.0 0.5 0.3 0.2 -0.1 -0.1 -0.5
Heart disease (mother) 0.8 0.9 5.2 0.4 0.1 0.1 -0.7 0.1 0.7 2.3 1.6 -1.1 -0.0 0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.8 0.9 3.0 1.7 0.3 1.4 0.4 1.3 1.1 0.6 0.7 1.0 0.2 0.1
Whole body fat mass 0.4 1.8 6.8 1.1 1.7 -1.4 2.6 -0.5 0.7 0.4 0.7 0.9 1.1 1.9
Leg fat mass (right) 0.4 1.5 5.8 0.8 1.4 -0.9 2.4 0.5 0.5 0.4 0.8 1.1 0.9 2.0
Arm predicted mass (right) 0.9 4.4 8.4 1.9 1.1 -0.5 2.4 -2.5 2.9 1.9 1.9 1.5 2.5 2.5
Pulse rate, automated reading 0.6 2.1 7.8 -1.1 2.1 -1.6 2.8 -1.9 -0.1 1.0 0.7 -1.1 -0.5 0.4
Alcohol intake frequency. 0.3 0.8 2.3 0.2 1.5 -0.5 0.4 1.4 -0.4 -0.4 -0.5 -0.7 -1.1 -1.4
Comparative height size at age 10 0.5 3.0 9.9 2.0 0.5 1.2 0.5 -2.2 3.1 1.3 1.9 1.2 1.4 1.9
Number of full sisters 1.5 1.9 4.7 -0.5 -0.4 -0.5 -2.0 0.4 -2.1 -2.2 -2.0 1.2 0.9 0.7
Suffer from ‘nerves’ 0.3 0.5 2.1 0.4 -1.5 -0.7 -1.1 -0.7 -0.2 0.6 0.4 -0.9 0.3 0.5
Overall health rating 0.5 1.1 3.5 0.7 1.9 -0.0 1.8 -0.4 -0.9 -0.3 -0.3 0.3 -1.6 -0.8
Chest pain or discomfort 0.5 0.8 3.9 0.5 1.3 1.4 2.0 -0.6 -0.0 -0.0 0.1 -0.3 0.2 0.5
Had major operations 0.4 0.5 1.6 -0.3 0.8 -1.3 1.2 -0.1 -0.3 -0.0 -0.1 -0.6 -1.1 -0.6
Age at last live birth 0.4 0.6 2.7 -0.3 0.5 0.9 0.3 -1.0 -1.6 -0.7 -1.1 -0.3 -0.1 -0.4
Family relationship satisfaction 0.9 1.1 10.4 0.2 -0.9 -3.2 0.2 -0.8 -0.2 -0.2 -0.5 -0.3 0.5 0.1
Leg pain on walking 1.1 1.4 4.1 -2.0 0.6 -0.8 0.9 -1.3 0.6 1.2 1.3 -1.7 -1.3 0.0
Qualifications: NVQ or HND or HNC or equivalent 0.3 0.3 1.4 0.3 -0.8 -1.0 0.4 -1.2 -0.0 -0.0 -0.1 -0.3 -0.1 -0.1
Commuting to job workplace: Car/motor vehicle 0.3 0.3 0.9 -0.5 -0.9 0.1 -0.4 -0.8 -0.5 -0.8 -0.5 -0.3 0.1 0.7
Illness, injury, bereavement, stress in last 2 years 1.9 2.3 9.2 -1.1 2.1 0.4 3.0 -1.0 0.0 0.4 0.1 -2.4 -1.5 -1.2
Medication: Aspirin 0.9 1.2 2.1 1.3 1.2 0.9 1.5 0.4 1.1 1.1 1.3 1.1 0.8 1.1
Supplements: Vitamin C 0.4 0.5 1.6 -0.1 0.2 -0.8 -0.9 -0.2 -1.3 -0.8 -1.1 -0.6 -0.4 -0.6
Knee pain experienced in last month 0.3 0.4 1.7 0.8 -0.6 -0.3 0.5 -1.3 -0.5 0.1 -0.1 -0.8 -0.9 -0.4
Hypertension (Self-reported) 0.9 2.5 14.7 -0.4 3.0 -0.4 3.8 -0.8 0.0 0.6 0.6 0.0 -1.3 -0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.0 2.4 9.0 0.9 1.1 0.4 1.4 0.2 0.5 0.8 0.9 2.1 3.0 2.5
Illnesses of father: Heart disease 0.6 0.9 2.9 -0.1 1.7 0.6 -0.0 1.0 1.0 1.2 1.2 -1.0 -0.5 -0.6
Illnesses of siblings: Diabetes 1.9 2.3 6.3 -0.6 -0.2 -0.5 -2.5 1.5 1.9 1.0 1.6 1.0 2.0 2.1
Smoking status: Previous 0.8 1.2 4.8 -1.9 -0.5 -1.6 -2.2 -0.4 -0.5 -0.1 0.1 -0.7 -0.8 1.0
Forced expiratory volume in 1-second (FEV1), predicted 0.8 1.7 7.2 1.3 1.3 -1.4 1.1 -2.7 1.3 0.5 0.3 1.0 1.2 0.5
Whole body fat-free mass 0.6 3.2 6.9 1.9 1.1 -1.2 2.0 -2.6 2.6 1.4 1.4 0.9 1.8 1.7
Leg fat-free mass (right) 0.7 3.5 6.6 2.3 1.5 -1.7 2.6 -2.4 2.4 1.4 1.4 0.8 1.6 1.5
Arm fat percentage (left) 0.2 0.9 3.2 0.7 1.2 -1.5 1.8 0.5 -0.3 -0.1 0.0 0.6 0.3 1.1
Average weekly red wine intake 0.7 1.0 3.3 0.5 0.3 -0.4 -1.8 1.2 1.0 0.8 0.8 1.2 1.3 0.6
Handedness (chirality/laterality): Left-handed 0.4 0.5 1.4 -0.6 0.3 -0.8 -0.2 -0.7 1.2 0.8 0.7 -0.9 -0.3 -0.8
Mood swings 0.4 0.7 2.9 1.3 1.7 -0.5 1.0 -0.2 0.6 0.9 0.5 0.2 0.1 -0.4
Loneliness, isolation 0.3 0.3 0.8 0.5 -0.7 0.3 -0.4 -0.9 0.2 0.9 0.6 -0.6 0.6 0.5
Long-standing illness, disability or infirmity 0.4 0.7 2.6 1.6 0.7 0.4 0.6 1.0 1.4 -0.6 -0.0 0.3 -0.3 -0.6
Ever had bowel cancer screening 2.4 2.8 9.3 -0.9 -1.0 0.5 -0.2 -0.7 -0.9 -1.3 -1.3 -2.6 -3.0 -2.9
Diabetes diagnosed by doctor 0.5 0.9 1.8 1.3 -1.3 -0.9 -1.0 0.8 0.8 0.4 0.5 1.4 0.9 0.2
Ever had stillbirth, spontaneous miscarriage or termination 0.7 0.8 3.8 0.7 -0.0 -0.1 0.8 -0.5 -2.0 -0.9 -1.4 -0.2 0.8 -0.2
Friendships satisfaction 1.2 1.4 5.2 0.0 -0.2 -1.2 0.0 -0.2 1.7 2.3 2.2 0.2 0.6 1.1
Qualifications: nursing, teaching 0.4 0.6 1.8 0.2 1.3 0.7 1.1 0.2 -0.8 -1.1 -1.0 0.7 0.5 -0.1
Commuting to job workplace: Walk 1.6 1.8 3.1 1.5 1.2 -1.7 0.1 1.1 1.0 1.6 1.3 1.6 1.8 0.8
Eye problems/disorders: Cataract 2.1 2.4 4.8 -1.2 2.1 1.6 2.2 2.1 1.1 1.8 2.0 -0.1 -0.6 0.2
Mouth/teeth dental problems: Mouth ulcers 0.6 0.9 3.8 -1.9 0.7 0.2 0.0 -0.3 -1.4 -0.8 -1.0 -1.2 -0.8 -0.1
Medication for cholesterol 1.2 1.9 10.4 -0.3 -2.3 0.1 -3.2 -1.5 0.2 0.4 0.2 -0.4 0.9 1.2
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 1.2 0.8 1.1 0.5 0.4 0.1 -0.4 -0.7 -0.4 0.9 -0.1 -0.3
Back pain experienced in last month 1.4 2.0 12.5 0.4 0.8 -1.9 1.5 -3.5 0.0 1.3 1.0 -0.1 -0.2 0.6
Mineral and other dietary supplements 0.2 0.3 1.7 -0.1 -0.4 -1.3 0.6 0.4 0.6 -0.3 -0.1 0.2 0.9 0.4
Breast cancer (self-reported) 1.8 2.1 4.8 0.9 -0.3 1.4 -1.1 2.2 1.7 1.4 1.9 1.1 1.3 1.6
Asthma (self-reported) 0.3 0.5 2.2 -0.6 0.7 -1.5 0.2 1.4 0.1 -0.3 -0.2 -0.9 0.3 0.2
Osteoporosis (self-reported) 0.4 0.5 2.9 -0.4 0.9 0.2 1.7 -1.3 -0.0 0.2 -0.1 0.0 0.1 -0.5
Osteoarthritis (self-reported) 0.5 0.7 2.5 1.6 -0.2 -1.1 0.2 0.6 0.9 0.4 0.7 1.0 0.4 0.6
Medication: Aspirin 1.2 1.6 2.8 1.2 1.3 1.1 1.4 0.7 1.4 1.5 1.7 1.2 0.6 1.2
Medication: Gliclazide 2.0 2.2 7.2 2.0 0.1 -0.6 -0.2 -0.5 1.6 2.7 2.2 1.1 1.6 1.4
Illnesses of father: None of the above (group 1) 1.9 2.3 9.1 0.6 -3.0 -1.2 -2.6 -0.4 -1.6 -1.4 -1.7 0.2 -0.2 -0.4
Smoking status: Current 0.5 0.8 2.3 1.0 0.1 -0.4 1.4 -0.8 1.5 0.1 0.3 0.9 1.1 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.2 0.5 1.9 -0.2 0.5 1.0 1.2 1.4 -1.0 0.0 -0.3 0.0 -0.1 0.3
Whole body water mass 0.6 3.3 7.2 2.0 1.1 -1.1 2.0 -2.6 2.7 1.4 1.5 1.0 1.9 1.9
Leg predicted mass (right) 0.7 3.6 6.8 2.3 1.5 -1.7 2.6 -2.5 2.5 1.4 1.5 0.9 1.6 1.6
Arm fat mass (left) 0.4 1.5 4.9 1.5 1.2 -1.2 2.2 0.1 0.8 0.2 0.6 1.1 1.1 1.7
Number of self-reported non-cancer illnesses 0.7 1.1 3.2 -0.3 1.8 0.6 1.7 1.1 0.2 -0.1 -0.2 -0.9 -1.3 -1.4
Average weekly champagne plus white wine intake 0.4 0.6 1.8 1.4 -0.3 -0.6 -0.9 -0.9 0.2 -0.6 -0.4 1.2 0.5 -0.4
Miserableness 0.5 0.9 4.1 0.6 0.5 0.3 0.1 0.5 0.9 2.0 1.6 -1.0 -0.3 -0.3
Guilty feelings 0.3 0.5 1.5 -0.4 0.9 -1.2 0.0 -1.1 -0.4 0.9 0.3 -0.8 0.2 -0.0
Wears glasses or contact lenses 0.4 0.4 1.5 -1.2 -0.3 1.0 0.2 1.1 0.2 -0.4 -0.1 -0.7 -0.1 0.4
Ever taken oral contraceptive pill 1.0 1.2 4.5 -0.3 -1.4 -2.1 -1.1 -1.3 -1.0 -1.1 -1.1 -0.3 -0.0 -0.0
Hearing aid user 0.7 0.8 3.2 -0.1 0.1 -0.9 1.0 -0.8 -1.8 -0.8 -1.1 0.2 0.1 0.9
Mother’s age at death 2.3 2.8 9.6 -1.1 -2.5 2.9 -3.1 -0.1 -0.9 -0.3 -0.5 -1.6 -1.3 -0.4
Financial situation satisfaction 1.2 1.4 3.3 0.7 0.3 -1.4 1.0 0.6 0.4 0.9 1.0 1.8 1.8 1.8
Tinnitus: Yes, now most or all of the time 2.1 2.5 6.7 0.1 -1.9 -2.1 -0.9 -1.9 -0.6 -2.6 -2.3 -1.0 -0.8 -0.9
Commuting to job workplace: Public transport 0.5 0.6 1.7 -1.1 0.7 -0.8 -0.3 0.1 -0.4 0.7 0.1 -1.0 -1.3 -1.0
Eye problems/disorders: Glaucoma 0.2 0.3 1.5 0.6 -0.0 -0.3 -0.3 -1.2 -0.4 -0.4 -0.4 0.5 0.3 -0.3
Medication: Blood pressure 1.8 3.3 21.5 0.2 3.1 0.1 4.6 0.8 1.1 1.3 1.3 0.7 0.3 0.1
Pain type(s) experienced in last month: Hip pain 0.3 0.3 1.0 -0.0 -0.7 -0.7 -0.7 -0.9 0.2 -0.1 0.0 0.2 0.7 1.0
Supplements: Fish oil (including cod liver oil) 0.4 0.5 3.2 0.4 0.3 1.8 -1.0 0.3 -0.5 -0.4 -0.4 0.4 -0.4 -0.2
High cholesterol (Self-reported) 0.4 0.7 4.0 -0.9 0.9 2.0 0.4 -0.2 0.1 0.3 0.0 -0.7 -0.7 -1.1
Medication: Bendroflumethiazide 0.8 1.2 5.7 -1.0 0.7 0.5 2.4 1.8 0.5 -0.6 -0.5 -0.9 -0.7 0.2
Medication: Paracetamol 0.7 1.1 5.4 0.7 1.1 -2.3 0.8 -0.9 0.2 1.3 1.1 0.9 0.3 0.6
Medication: Lisinopril 0.5 0.6 1.7 1.1 0.7 0.2 1.3 1.3 -0.5 -0.3 -0.5 1.1 0.6 0.0
Medication: Atorvastatin 0.2 0.3 1.3 -0.7 -0.3 0.3 0.4 0.4 -0.0 0.5 0.4 -0.1 0.5 1.1
Illnesses of father: High blood pressure 0.9 1.1 4.5 0.4 2.1 0.6 1.8 -0.4 0.8 1.0 1.0 0.6 0.6 0.6
Alcohol drinker status: Never 1.2 1.4 2.7 1.6 -1.0 -1.1 -1.5 1.3 1.4 1.3 1.5 0.7 0.5 0.9
Ever smoked 0.6 1.0 5.0 -0.1 -0.8 -2.0 -2.2 -0.7 0.8 -0.3 -0.0 0.2 0.2 0.4
Basal metabolic rate 0.6 3.4 6.7 2.1 1.2 -1.3 2.1 -2.2 2.6 1.4 1.5 1.2 2.0 2.0
Leg fat percentage (left) 0.2 0.8 2.8 -0.3 0.9 0.1 1.5 1.4 -0.1 0.2 0.5 0.5 0.3 1.7
Arm fat-free mass (left) 0.7 3.6 8.2 1.8 1.0 -0.3 2.2 -1.9 2.9 1.6 1.8 1.3 2.3 2.5
Number of operations (self-reported) 0.5 0.7 2.1 1.4 0.2 -0.1 0.8 -0.2 -1.4 -1.1 -1.1 -0.2 -0.6 -0.3
Average weekly beer plus cider intake 1.0 1.4 4.0 -0.9 1.2 -0.8 2.0 1.0 -1.5 -1.2 -1.3 -1.2 -0.8 -0.4
Irritability 0.3 0.5 1.8 1.1 0.3 0.6 0.3 -0.2 0.8 1.4 0.9 0.4 0.5 -0.3
Risk taking 1.5 2.1 10.7 0.0 1.3 -3.3 1.3 -2.6 -0.6 -1.0 -0.9 0.7 0.2 0.3
Ever had prostate specific antigen (PSA) test 0.6 0.7 2.5 0.6 -0.3 0.3 -1.5 0.1 0.1 1.6 1.0 -1.1 0.2 0.6
Fractured/broken bones in last 5 years 1.1 1.4 2.9 1.7 1.4 1.3 1.4 -0.8 0.9 0.9 1.1 1.2 1.1 1.1
Age started oral contraceptive pill 0.8 1.0 3.6 -1.9 0.6 0.6 1.0 -1.0 0.6 1.0 0.8 -1.4 0.0 1.0
Diastolic blood pressure, automated reading 0.4 1.2 5.0 1.1 0.9 2.2 1.4 1.1 -0.6 -0.2 -0.1 1.1 0.7 0.9
Ever depressed for a whole week 1.4 1.7 7.4 1.2 -2.7 -0.6 -1.9 2.1 0.0 0.5 0.3 -1.1 -0.3 -0.3
Unable to work because of sickness or disability 1.0 1.3 2.9 1.7 1.0 -0.9 0.6 1.3 1.5 1.6 1.5 0.1 -0.4 -0.1
Commuting to job workplace: Cycle 0.9 1.0 4.1 0.3 2.0 -0.8 1.4 0.5 1.3 0.4 0.6 1.1 0.9 0.5
Myopia 0.3 0.4 1.1 0.2 0.1 -0.2 1.0 -0.8 0.1 -0.9 -0.9 -0.4 -0.4 -0.9
Vascular/heart problems diagnosed by doctor 0.9 2.4 14.4 -0.8 -2.6 -0.9 -3.8 0.8 -0.1 -0.4 -0.3 -0.0 1.6 0.7
Cholesterol lowering medication 0.6 0.9 5.0 0.2 0.6 2.2 0.7 1.3 0.6 0.2 0.3 0.0 -0.6 -1.2
Medication: Omeprazole (e.g. Zanprol) 1.5 1.8 3.8 1.5 1.0 -0.0 1.6 -0.3 1.2 1.1 1.4 1.6 1.6 1.9
Pain experienced in last month 0.8 1.3 5.4 0.5 -0.3 1.3 -0.1 2.3 0.8 0.2 0.5 1.5 1.7 0.6
Supplements: Calcium 1.5 1.6 8.0 -0.4 -1.3 -1.5 -1.3 -2.8 -0.7 -0.7 -0.7 -0.6 -1.2 -0.9
Basal cell carcinoma (self-reported) 1.9 2.3 4.7 1.9 -0.7 -0.8 -0.5 1.0 2.2 1.8 2.1 1.7 1.8 0.9
Heart attack/myocardial infarction (self-reported) 1.6 2.1 5.4 2.3 0.0 1.0 1.9 -1.6 -1.1 -0.8 -1.3 -0.8 -1.7 -1.9
Deep venous thrombosis (DVT) (self-reported) 0.5 0.6 2.2 -0.1 1.0 -1.1 0.6 0.5 0.4 0.5 0.5 -1.5 -0.9 -0.1
Heart disease (siblings) 0.7 0.8 2.9 0.5 -0.3 1.6 -1.4 1.7 -0.3 -0.5 -0.6 0.5 -0.0 -0.7
Alcohol drinker status: Previous 0.8 0.9 5.6 0.8 2.4 -1.0 0.8 -0.7 0.7 0.8 0.6 0.3 0.5 -0.1
Pack years of smoking 0.8 1.1 4.2 1.3 1.0 -1.0 0.1 -2.1 0.5 1.0 0.8 1.1 0.8 1.0
Impedance of whole body 0.1 0.5 1.1 -0.8 -0.2 -0.3 -0.6 -0.6 -1.1 -0.9 -0.7 0.2 -0.7 -1.0
Leg fat mass (left) 0.3 1.4 5.7 0.6 1.4 -0.8 2.4 0.3 0.5 0.4 0.7 1.0 0.8 1.9
Arm predicted mass (left) 0.7 3.6 8.2 1.8 1.1 -0.5 2.3 -2.1 2.9 1.5 1.7 1.3 2.3 2.3