Hub : Genes

ISG20

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Artery Tibial	0.1270	0.0557	8.8e-03	0.006	NA	0.023	NA	0.020	1.1e-01	NA	6.0e-03	NA	9.6e-03
2	GTEx	Breast Mammary Tissue	0.1730	0.0680	8.5e-03	0.040	NA	0.070	NA	0.067	3.9e-03	NA	1.9e-04	NA	2.5e-04
3	GTEx	Breast Mammary Tissue (Male)	0.0829	0.0855	2.1e-01	-0.008	NA	0.077	NA	0.124	5.2e-01	NA	7.5e-03	NA	8.7e-04
4	GTEx	Breast Mammary Tissue (Female)	0.1726	0.0865	4.3e-02	0.011	NA	-0.009	NA	0.016	1.5e-01	NA	7.2e-01	NA	1.1e-01
5	GTEx	Testis	0.3910	0.0900	2.8e-05	0.230	NA	0.264	NA	0.220	1.4e-10	NA	4.0e-12	NA	3.8e-10
6	GTEx	Whole Blood	0.1290	0.0470	5.8e-03	0.111	NA	0.080	NA	0.107	2.3e-10	NA	7.9e-08	NA	4.9e-10
7	NTR	Blood	0.0546	0.0146	4.6e-06	0.013	0.020	0.029	0.023	0.032	3.9e-05	4.0e-07	7.8e-10	4.5e-08	1.3e-10
8	YFS	Blood	0.2735	0.0310	0.0e+00	0.166	0.187	0.222	0.210	0.228	6.8e-52	6.1e-59	6.2e-71	7.8e-67	5.9e-73
9	TCGA	Kidney Renal Clear Cell Carcinoma	0.0309	0.0173	7.9e-03	0.010	0.019	0.017	NA	0.012	2.2e-02	3.0e-03	4.3e-03	NA	1.4e-02
10	TCGA	Pheochromocytoma and Paraganglioma	0.1900	0.0760	3.9e-05	0.154	0.102	0.105	NA	0.117	1.1e-06	7.6e-05	6.0e-05	NA	2.1e-05
11	TCGA	Skin Cutaneous Melanoma	0.2740	0.1160	6.5e-03	0.166	0.098	0.142	NA	0.124	3.3e-05	1.4e-03	1.3e-04	NA	3.3e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11
Bipolar Disorder (2018)	0.2	0.3	1.3	0.4	-0.3	0.0	0.4	-0.9	0.7	-0.1	0.2	0.0	1.1	0.9
Bipolar Disorder or Schizophrenia	0.8	2.0	7.0	-0.2	-2.1	0.0	-0.8	-2.6	-1.6	-1.1	-1.6	-1.6	-0.3	-0.7
Depressed Affect (Nagel 2018)	0.2	0.4	1.0	0.6	-1.0	0.0	-0.5	-0.8	-0.3	0.6	0.0	-1.0	-0.4	-0.8
Depression (Nagel 2018)	0.4	0.6	1.7	0.6	-1.2	0.0	0.7	-0.8	-0.4	0.2	0.0	0.4	1.3	1.2
Intelligence (Savage-Jansen 2018)	0.6	1.8	5.3	-1.7	1.1	0.0	-1.6	0.5	0.8	1.2	1.0	-2.3	-1.6	-1.5
Neuroticism (Nagel 2018)	0.2	0.4	2.4	0.6	0.2	0.0	0.2	-0.3	0.3	1.6	0.9	-0.8	0.3	-0.3
Schizophrenia (2018)	1.6	3.4	7.1	-0.5	-2.3	0.0	-1.4	-2.7	-2.7	-1.4	-2.1	-2.1	-1.3	-1.6
Schizophrenia vs Biploar Disorder	1.2	1.5	3.9	0.5	-1.6	0.0	-1.6	-2.0	-1.4	-1.2	-1.3	0.3	-0.9	-1.3
Worry (Nagel 2018)	0.2	0.5	2.1	0.7	-0.5	0.0	-0.1	0.9	0.3	1.5	0.9	-1.0	0.3	-0.2
Alzheimer’s Disease (in mother)	0.7	0.8	2.4	0.8	1.1	0.5	0.9	1.6	-0.5	-0.4	-0.6	1.2	0.7	-0.9
Alzheimer’s Disease (in father)	0.8	0.9	5.9	0.2	-1.4	-2.4	0.8	-0.2	0.6	0.3	0.2	-0.4	-0.3	-0.3
Alzheimer’s Disease (including proxy)	0.2	0.4	1.4	0.4	0.0	-1.0	0.8	-0.3	-0.5	-0.1	-0.5	0.2	-0.2	-1.2
Crohns Disease (2017)	0.6	1.4	4.3	-0.1	0.3	-0.5	0.3	-0.1	1.4	0.7	1.1	1.7	2.0	2.1
Irritable Bowel Disease (IBD)	0.3	0.6	2.3	-0.4	-0.2	-0.9	0.3	-0.9	0.4	-0.5	0.2	1.1	1.1	1.5
Ulcerative Colitis (UC)	0.4	0.8	1.9	-1.0	-0.2	-1.1	0.3	-1.2	-1.0	-1.4	-1.0	-0.6	-0.9	-0.4
Major Depression (MDD)	0.9	1.1	5.1	1.5	-0.2	0.0	0.5	2.3	1.4	1.0	1.1	0.8	0.2	0.1
Reaction Time	0.3	0.6	1.6	-0.2	-0.8	0.1	-1.2	1.3	0.7	0.9	0.9	0.2	0.0	0.1
Verbal and Numeric Reasoning (VNR)	0.2	0.5	1.2	-1.0	-0.5	0.0	-0.6	-0.6	0.6	1.1	1.1	-0.7	-0.0	0.4
Breast Cancer	0.5	1.2	2.9	0.1	-1.7	-1.6	-0.8	-1.2	-0.3	-0.3	-0.3	-1.4	-1.6	-0.7
Ovarian Cancer	1.3	1.8	4.7	-2.0	-1.6	0.2	-1.4	-2.2	-0.2	0.9	0.6	-2.2	-0.3	0.5
Prostate Cancer	0.7	0.9	2.5	-0.4	-0.3	0.1	0.9	-0.5	-0.9	-1.6	-1.4	-0.9	-1.2	-1.0
Age at First Birth	0.4	0.5	1.3	-0.5	0.7	1.1	0.1	1.0	-0.0	-0.7	-0.4	-1.0	-0.7	-0.6
Bipolar Disorder (2011)	0.1	0.1	1.5	0.0	0.0	0.0	0.0	0.0	0.0	0.0	-1.2	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.4	0.6	1.6	0.5	0.0	0.0	1.1	-1.3	-1.1	-0.0	-0.6	-0.3	-0.9	-1.0
Coronary Artery Disease (CAD)	0.3	0.3	0.6	-0.3	-0.8	0.0	0.5	-0.8	-0.3	-0.6	-0.5	0.3	-0.7	-0.8
Crohns Disease (2012)	1.7	2.7	8.6	1.9	-1.2	0.0	-0.8	-1.4	1.6	0.8	1.2	2.9	2.5	1.7
Mean Putamen Volume	0.6	0.7	1.8	-0.8	-1.3	0.0	-1.1	1.4	0.3	-0.1	0.1	-0.3	-0.9	-0.9
Fasting Glucose	0.9	1.0	2.7	-0.2	0.4	0.0	-0.0	-1.1	1.6	0.8	0.9	-0.8	-1.7	-1.6
HbA1C	0.9	1.0	3.5	1.9	-0.6	-0.9	1.6	-0.6	0.9	-0.3	-0.1	0.2	-1.0	-1.2
HDL Cholesterol	1.2	2.1	6.4	-1.0	-0.5	0.0	0.9	-1.0	-1.7	-2.5	-2.4	-1.0	-1.4	-1.3
LDL Cholesterol	0.7	1.1	3.2	0.1	1.0	0.0	-0.7	1.4	1.5	1.7	1.8	0.3	-0.5	-0.7
Lupus	1.3	1.9	5.0	-0.5	-0.9	-2.2	-2.1	-1.8	1.3	1.1	1.0	-1.6	0.2	1.0
Neuroticism (2016)	0.6	0.9	3.9	-1.0	1.3	-0.2	2.0	0.3	1.0	0.9	1.0	-0.6	-0.7	-0.4
Primary Biliary Cirrhosis	0.4	0.6	1.5	0.9	-0.5	0.0	-0.2	-0.5	1.2	0.6	0.6	0.8	1.2	0.9
Rheumatoid Arthritis	1.6	2.2	6.4	1.3	0.2	0.0	0.4	-1.0	2.0	2.5	2.3	1.4	1.4	1.4
Schizophrenia (2014)	1.9	4.2	13.0	0.4	-3.1	0.0	-1.5	-3.6	-2.3	-2.0	-2.3	-1.1	-1.4	-1.8
Triglycerides	0.1	0.2	1.0	0.5	1.0	0.0	0.6	0.3	0.1	0.7	0.5	0.3	-0.2	-0.3
Type 2 Diabetes (T2D) (2012)	0.4	0.4	2.0	0.2	-1.4	0.0	-1.2	-0.8	0.2	-0.3	-0.1	0.3	0.2	0.2
Ulcerative Colitis	0.3	0.5	2.8	-0.0	-1.7	0.0	-0.1	-1.5	0.1	-0.1	0.1	0.5	0.1	0.1
Blood Eosinophil Count	0.2	1.5	4.5	0.8	-0.1	0.8	-1.5	2.0	-0.8	-0.7	-0.8	-1.1	-1.4	-2.1
Blood Platelet Count	0.3	3.0	9.5	-0.7	1.0	-1.2	-0.2	0.6	1.9	2.8	3.1	0.4	1.5	2.4
Blood Red Count	0.1	1.2	4.2	1.9	0.0	0.3	0.3	0.7	2.0	1.0	1.1	-0.3	-0.4	-1.4
Blood White Count	0.2	1.7	8.0	0.1	2.8	0.8	1.4	1.9	1.4	0.8	0.7	0.4	0.4	-1.3
Heel T-Score	0.5	4.3	9.0	0.8	-1.9	0.6	-0.4	3.0	-2.1	-2.6	-2.5	-1.6	-2.3	-3.0
BMI	0.1	0.7	2.6	1.4	0.6	-0.5	1.6	0.7	-0.4	-0.4	-0.4	0.5	0.6	1.0
Height	0.4	8.6	41.7	3.7	0.2	-2.7	1.0	-6.5	3.6	0.7	1.1	1.3	2.7	2.7
Waist Hip Ratio (WHR)	0.1	0.5	2.5	-0.1	1.6	0.1	1.0	1.0	0.0	-0.0	0.2	0.2	-0.6	-0.6
Systolic Blood Pressure	0.4	1.9	8.1	1.1	2.3	0.7	2.9	1.7	0.5	-0.1	0.0	1.7	-0.1	-0.1
Smoking Status	0.3	0.8	2.0	-0.6	-0.8	-1.2	-0.5	-1.4	1.2	0.7	1.0	0.3	0.3	0.8
Allergy or Eczema	0.7	1.7	3.7	-1.1	0.1	-1.9	0.3	-1.4	-0.6	-1.2	-1.0	-1.9	-1.7	-1.8
Cardiovascular Disease	0.6	1.9	11.1	-0.2	2.9	-0.5	3.3	-0.4	0.1	0.4	0.2	-0.1	-0.8	-0.3
Hypothyroidism (self reported)	0.6	1.4	5.7	0.7	0.7	0.1	0.6	2.4	1.1	0.6	0.7	1.6	1.4	1.2
Respiratory disease	0.3	0.7	3.3	-1.1	1.2	-1.8	0.2	-0.1	0.1	-0.8	-0.7	-0.6	-0.2	-0.8
Type 2 Diabetes (T2D) (2018)	0.3	0.6	2.3	1.2	-0.7	0.3	-0.9	1.5	0.7	-0.1	-0.1	0.7	0.5	-0.8
Lung FEV1/FVC ratio	0.2	1.2	5.9	-0.4	1.2	-1.9	2.4	-0.7	-0.6	-0.7	-0.5	-0.7	-0.2	-0.3
Lung FVC	0.2	1.2	7.3	0.5	0.7	0.2	0.7	2.7	-1.9	-0.1	-0.6	-0.0	-0.3	-0.7
Neuroticism	0.3	0.7	3.2	0.2	-0.3	0.4	-0.2	-0.7	-0.3	1.4	0.6	-1.8	-0.8	-0.8
Chronotype (morning person)	0.1	0.3	1.5	0.6	-1.2	0.4	-0.4	0.3	-0.9	0.1	0.0	0.7	0.1	-0.1
Hair Pigment	0.1	2.6	7.0	-0.4	-0.0	0.0	-0.5	1.9	1.8	0.7	1.6	2.6	2.3	2.5
Tanning	0.3	3.3	9.0	-0.5	-0.6	0.5	-0.2	-0.1	-2.3	-2.0	-2.2	-2.6	-3.0	-2.4
Hand grip strength (left)	0.7	1.8	5.4	2.3	0.2	1.4	1.7	0.0	-0.1	-0.0	-0.2	1.9	2.2	0.9
Number of treatments/medications taken	0.3	0.6	2.1	0.8	1.2	-0.0	1.3	1.5	-0.0	0.4	0.4	0.6	-0.2	0.4
Average weekly spirits intake	0.5	0.6	2.0	1.4	-1.1	1.3	0.6	-0.7	-0.1	-0.5	-0.2	0.4	0.5	0.9
Sensitivity / hurt feelings	2.0	3.5	8.4	1.3	2.5	-0.0	1.0	1.2	2.6	2.9	2.8	0.4	1.3	1.6
Frequency of depressed mood in last 2 weeks	0.5	0.8	2.0	1.2	-0.8	-0.1	1.1	-0.6	0.6	0.5	0.4	0.4	1.3	1.4
Hearing difficulty/problems: Yes	1.5	2.3	6.6	-1.1	0.2	-0.2	1.4	-2.2	-2.3	-2.2	-2.6	-0.4	-0.1	-0.1
Relative age of first facial hair	1.1	2.2	12.3	0.3	0.3	-3.5	-0.1	-2.4	-1.2	-0.8	-1.2	-1.0	-0.6	-1.0
Other serious medical condition/disability diagnosed by doctor	0.5	0.6	2.4	0.4	0.7	0.1	0.1	0.3	1.5	1.0	1.2	0.3	-0.7	-0.8
Ever used hormone-replacement therapy (HRT)	1.3	1.6	4.5	0.2	-1.1	-1.2	0.5	1.3	-1.9	-2.1	-1.9	-0.3	-1.0	-0.7
Ever had hysterectomy (womb removed)	1.1	1.2	3.4	1.3	-0.3	0.5	-0.3	-1.0	-1.6	-1.8	-1.8	-0.1	-0.5	-0.9
Systolic blood pressure, automated reading	0.4	1.1	7.0	0.3	0.9	2.6	1.6	1.2	0.0	0.1	0.3	0.4	-0.3	0.3
Eye problems/disorders: Diabetes related eye disease	0.8	0.9	3.8	-0.3	-0.7	-0.2	-0.8	-1.9	-1.0	0.0	-0.7	-0.8	-1.1	-1.2
Angina	0.5	0.6	2.3	0.1	0.6	1.0	-0.2	0.2	-0.5	-0.3	-0.5	-0.7	-1.5	-1.4
Medication for hormone replacement therapy	1.5	1.6	3.6	0.1	-0.3	-1.3	-0.4	0.1	-1.9	-1.8	-1.7	-0.4	-1.7	-1.8
Vitamin and mineral supplements	1.0	1.4	4.5	1.0	-0.1	1.3	0.4	1.0	2.1	0.1	0.9	1.7	1.6	0.8
Supplements: Zinc	1.2	1.3	4.1	-2.0	-0.6	0.2	-0.8	0.2	-1.6	-1.1	-1.2	-1.5	-1.0	-0.7
Medication: Co-codamol	0.7	0.8	3.4	-0.7	0.3	-1.0	0.7	1.8	-0.3	-1.1	-1.1	-0.4	-0.2	-0.6
Medication: Metformin	0.3	0.4	0.9	1.0	0.0	0.1	0.7	-0.0	0.8	0.7	0.8	0.9	0.6	0.6
Diabetes (father)	0.2	0.2	0.9	-0.0	-0.4	0.6	-0.1	-0.5	-0.4	-0.2	-0.0	-0.8	-0.9	0.1
Diabetes (mother)	0.9	1.1	7.5	-0.8	1.4	0.9	2.7	0.4	0.2	0.8	0.6	-0.4	-0.1	0.5
Severe depression (siblings)	0.8	0.8	1.9	-1.2	0.9	0.6	0.2	0.8	-0.3	1.3	0.7	-0.8	1.1	1.4
Pack years adult smoking proportion	1.0	1.6	5.8	1.8	0.9	-1.2	0.5	-2.4	0.1	1.0	0.6	1.4	1.1	1.1
Impedance of leg (right)	0.1	0.5	1.5	-1.2	-0.6	0.2	-1.1	-0.0	-1.2	-0.8	-0.6	0.3	-0.4	-0.6
Leg fat-free mass (left)	0.7	3.5	6.2	2.4	1.5	-1.8	2.5	-2.1	2.4	1.4	1.4	1.1	1.7	1.6
Trunk fat percentage	0.3	1.4	6.3	1.1	1.6	-1.2	2.5	-0.3	0.2	0.2	0.4	1.0	0.6	1.4
Hand grip strength (right)	0.2	0.6	3.5	1.0	0.1	1.9	1.0	-0.4	-0.6	0.1	-0.3	0.0	0.8	0.0
Townsend deprivation index at recruitment	0.7	1.0	4.2	2.1	0.9	-1.6	-0.7	-0.3	0.1	1.4	0.9	0.5	0.5	0.1
Current tobacco smoking	0.3	0.6	1.5	0.7	-0.1	-0.6	1.2	-0.4	1.2	-0.4	-0.1	0.8	1.1	-0.3
Average weekly fortified wine intake	0.5	0.6	1.5	0.4	-0.2	-0.2	-0.4	0.4	0.8	1.0	1.2	1.1	1.0	0.9
Maternal smoking around birth	0.8	1.2	4.9	-2.2	-1.6	1.6	-0.9	0.0	-0.6	-1.1	-0.8	-0.8	-0.0	0.2
Fed-up feelings	0.2	0.3	1.4	1.2	-0.0	-0.1	0.5	0.1	0.7	0.8	0.6	0.3	0.6	0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	3.0	-0.0	-1.5	-0.9	-0.8	-1.7	-1.2	-0.1	-0.5	0.4	1.2	1.1
Relative age voice broke	0.6	0.9	3.8	-0.1	0.3	-1.9	-0.0	-0.1	-0.2	-0.0	-0.4	-1.9	-0.9	-1.1
Taking other prescription medications	1.2	1.8	5.0	1.3	0.8	0.5	1.4	2.0	0.2	-0.1	0.2	1.4	2.2	2.0
Age when periods started (menarche)	0.4	1.1	4.2	0.7	0.6	-2.0	0.6	-0.0	-0.3	-0.7	-0.5	-0.5	-1.0	-2.0
Bilateral oophorectomy (both ovaries removed)	1.5	1.7	4.0	0.8	-2.0	0.1	-1.4	-0.8	-1.9	-1.9	-1.6	1.4	0.1	-0.1
Heel bone mineral density (BMD) T-score, automated (left)	1.3	2.8	5.8	0.7	-2.0	-0.0	-0.7	2.4	-1.8	-2.3	-2.2	-0.5	-1.4	-2.2
Tinnitus: Yes, but not now, but have in the past	1.2	1.3	5.9	-2.4	-1.3	0.3	-0.6	0.1	-1.0	-0.8	-0.8	-1.4	-1.3	-0.6
Qualifications: CSEs or equivalent	0.4	0.6	2.0	-0.1	0.7	-0.7	1.4	0.3	0.5	-0.2	-0.1	-0.3	-0.9	-1.4
Serious illness, injury or assault to yourself	0.4	0.5	2.0	0.7	0.8	0.6	-0.3	0.2	0.7	0.3	0.4	-0.5	-1.4	-1.0
High blood pressure	0.7	2.0	11.6	-0.4	2.5	0.6	3.4	-0.9	0.4	0.9	0.9	0.2	-1.1	0.2
Hayfever, allergic rhinitis or eczema	0.6	1.2	3.5	-0.7	-0.5	-1.9	-0.4	-1.0	-0.9	-1.2	-1.0	-1.4	-1.3	-0.9
Multivitamins +/- minerals	0.7	0.9	2.7	-0.1	-0.4	-1.1	-0.3	-0.4	-1.7	-0.3	-0.8	-1.5	-1.3	-0.8
Stomach or abdominal pain in last month	0.3	0.3	0.8	0.3	0.5	-0.4	0.5	-0.7	0.9	0.5	0.8	0.2	0.7	0.6
Supplements: Glucosamine	0.4	0.6	1.8	-0.2	0.1	0.2	0.0	-0.2	1.3	1.1	1.3	0.1	0.1	1.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	3.6	-1.9	0.8	1.2	-0.0	0.9	-0.9	-1.3	-1.0	-0.9	-1.3	-0.9
Medication: Atenolol	0.2	0.2	0.5	-0.7	-0.3	0.2	0.4	0.7	-0.3	0.5	0.2	0.3	0.2	0.7
Medication: Levothyroxine sodium	0.8	1.3	8.3	-0.2	1.0	1.2	1.5	2.9	-0.0	-0.9	-0.6	0.4	0.0	0.0
Sitting height	1.1	7.8	28.6	1.2	0.6	-1.0	1.6	-4.6	5.3	2.6	3.2	0.8	2.4	2.6
Chronic bronchitis/emphysema (father)	1.1	1.2	3.7	-1.9	0.6	0.8	0.8	1.4	-1.0	-0.5	-0.8	-1.6	-1.1	-0.8
High blood pressure (mother)	0.5	0.7	5.6	2.4	0.1	-0.1	0.5	0.1	0.4	0.5	0.1	1.1	0.1	-0.8
Body mass index (BMI)	0.3	1.3	3.9	1.3	1.1	-0.3	2.0	1.6	0.3	0.1	0.4	1.0	0.8	1.5
Impedance of leg (left)	0.1	0.6	2.7	-1.6	-0.4	0.6	-1.0	-0.4	-1.1	-0.5	-0.4	0.1	-0.4	-0.3
Leg predicted mass (left)	0.6	3.4	5.8	2.4	1.5	-1.7	2.4	-2.1	2.4	1.4	1.4	1.1	1.7	1.7
Trunk fat mass	0.5	2.1	8.0	1.2	2.0	-1.4	2.8	-1.0	0.8	0.6	0.8	0.9	0.9	1.7
Waist circumference	0.5	1.8	6.8	1.3	1.9	-0.7	2.6	0.5	1.3	0.7	1.2	0.9	0.5	1.4
Number of incorrect matches in round	0.5	0.9	3.1	-0.0	-0.2	0.0	0.3	-0.1	-0.6	-1.2	-1.3	-0.8	-1.5	-1.8
Past tobacco smoking	0.5	0.9	4.3	0.8	0.6	1.7	2.1	0.8	-0.6	-0.1	-0.4	0.1	0.1	-0.9
Alcohol usually taken with meals	0.6	0.9	3.5	0.3	1.8	0.2	-0.4	0.3	0.7	1.9	1.5	-0.1	0.7	0.0
Nervous feelings	0.5	0.9	4.2	-0.4	0.8	0.3	1.0	-0.2	0.5	2.0	1.3	-1.3	0.3	-0.1
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.0	6.3	-0.1	-1.1	-0.9	-0.4	-2.5	-1.5	0.0	-0.4	-0.4	0.1	0.5
Hearing difficulty/problems with background noise	0.7	1.2	4.0	-0.8	0.5	0.0	0.9	-1.0	-1.4	-2.0	-2.0	0.4	0.5	0.4
Hair/balding pattern: Pattern 2	1.1	1.4	4.8	-0.3	1.0	1.2	0.7	2.2	0.4	0.1	0.7	1.8	1.1	1.7
Had menopause	1.8	2.2	7.0	-1.5	1.1	2.6	1.7	0.9	-0.8	-1.3	-1.4	-1.7	-1.2	-1.2
Had other major operations	1.1	1.4	8.8	3.0	-0.8	1.9	0.3	0.2	-0.3	-0.7	-0.3	1.1	0.5	0.1
Forced vital capacity (FVC)	0.6	2.2	6.8	2.4	1.0	-0.9	1.5	-0.2	-0.3	0.2	-0.2	2.3	2.6	1.4
Heel bone mineral density (BMD) T-score, automated (right)	1.3	2.9	7.9	0.4	-2.4	-0.2	-1.2	2.8	-1.8	-1.9	-1.9	0.0	-1.3	-2.1
Ever unenthusiastic/disinterested for a whole week	1.0	1.3	4.8	2.0	-2.2	-1.2	-1.8	-0.2	-0.5	-0.1	-0.3	0.1	-0.3	-0.6
Qualifications: None of the above	0.2	0.5	1.6	0.0	0.6	-0.4	0.7	0.7	-1.0	-1.3	-0.9	0.5	-0.1	0.2
Financial difficulties in last 2 years	1.8	2.4	8.6	0.9	-1.4	-0.6	-1.9	0.2	0.8	1.1	1.1	1.5	2.9	2.3
Mouth/teeth dental problems	0.8	1.3	5.2	1.8	-0.0	1.6	0.7	1.0	0.4	-0.6	-0.1	2.3	0.9	0.4
Heart attack	1.8	2.3	5.5	2.3	-0.1	1.0	2.0	-1.2	-1.3	-1.2	-1.5	-0.8	-1.9	-2.1
Allergy	0.8	1.8	5.0	0.8	-0.7	2.2	-0.4	0.4	1.7	1.8	1.8	1.6	1.0	1.1
Pain all over the body in last month	0.8	0.9	2.9	-0.1	0.0	0.8	-0.7	0.9	-0.7	-0.9	-1.0	-0.8	-1.5	-1.7
Diabetes (self-reported)	0.4	0.7	1.9	1.3	-0.7	-1.4	-0.9	0.7	0.6	0.5	0.4	0.8	0.6	-0.0
Hayfever/allergic rhinitis (self-reported)	0.8	1.0	4.5	-2.1	-0.0	-0.2	-0.7	0.6	0.8	0.2	0.4	-1.9	-1.0	-0.0
Medication: Ramipril	1.0	1.3	2.9	1.7	0.5	-0.6	1.6	-1.6	0.6	1.2	0.9	1.2	0.9	0.8
Medication: Simvastatin	0.7	1.0	4.4	0.8	0.8	2.1	0.9	0.2	0.2	-0.3	-0.2	0.1	-1.4	-1.6
Fluid intelligence score	0.1	0.3	1.3	-0.4	-1.2	0.9	-0.8	-0.1	0.0	0.2	0.2	-0.2	-0.1	-0.0
Illnesses of siblings	0.3	0.4	2.9	0.4	0.0	-0.9	0.2	-1.7	0.0	-0.2	0.1	0.4	0.4	0.6
Neuroticism score	0.5	1.1	5.7	0.8	0.5	-0.7	0.3	-0.5	0.9	2.4	1.7	-0.8	0.0	0.1
Weight	0.6	3.0	8.1	2.0	1.8	-1.1	2.8	-0.9	1.9	1.0	1.4	1.3	1.6	2.2
Impedance of arm (right)	0.3	1.2	3.1	-0.7	-0.1	-1.2	-0.5	-0.7	-1.2	-1.2	-1.1	-0.9	-1.8	-1.6
Arm fat percentage (right)	0.2	0.7	2.5	0.7	1.1	-1.4	1.6	0.7	-0.3	-0.4	-0.1	0.6	0.2	1.0
Trunk fat-free mass	0.4	2.4	6.7	1.4	0.7	-1.1	1.2	-2.6	2.5	1.2	1.2	0.6	1.7	1.6
Hip circumference	0.9	4.1	9.1	1.8	1.8	-1.4	2.4	-0.9	2.5	1.6	2.0	1.8	2.1	3.0
Time employed in main current job	1.3	1.5	3.2	-0.9	0.1	1.6	-0.7	1.8	1.8	1.4	1.6	-1.2	-0.5	-0.3
Alcohol intake versus 10 years previously	0.7	1.0	3.0	-1.4	0.3	0.0	-0.3	0.5	-1.7	0.1	-0.4	-1.6	-1.6	-0.8
Father’s age at death	0.5	0.7	2.6	-0.7	-0.9	0.2	-0.4	-0.8	-0.8	0.4	0.1	-1.6	-1.2	-0.6
Worrier / anxious feelings	0.8	1.5	6.2	0.4	1.2	0.8	0.5	0.1	1.8	2.5	1.9	-0.6	-0.2	-0.5
Frequency of tiredness / lethargy in last 2 weeks	1.3	2.1	6.2	-0.0	1.0	-1.0	1.4	-1.2	-1.6	-0.9	-1.2	-1.8	-2.5	-1.7
Falls in the last year	0.7	0.9	4.3	-1.1	-0.5	-0.1	-2.1	-0.5	0.5	0.3	0.3	-1.4	-1.0	-0.9
Hair/balding pattern: Pattern 3	0.6	0.9	2.7	1.5	-0.4	0.2	1.3	-1.4	0.1	-0.4	-0.6	-0.2	-0.7	-1.7
Number of live births	1.1	1.6	8.0	-0.2	2.2	-1.4	2.8	-0.2	-0.6	-0.4	-0.2	0.3	0.5	1.0
Forced expiratory volume in 1-second (FEV1)	0.7	2.3	5.9	2.3	1.2	-0.8	2.1	-0.1	-0.3	0.5	0.0	2.3	2.4	1.3
Pulse rate	0.6	1.0	3.8	-1.1	1.3	-2.0	1.2	-1.2	0.5	0.4	0.4	-0.7	-0.4	-0.1
Happiness	0.7	0.8	2.7	1.6	-1.1	-1.3	-0.4	0.1	1.2	0.8	0.9	0.4	-0.5	-0.3
Noisy workplace	1.1	1.3	3.5	-0.3	-0.1	0.2	1.1	0.0	-0.7	-1.6	-1.3	-1.3	-1.8	-1.9
Qualifications: A levels/AS levels or equivalent	0.2	0.4	1.6	0.2	-0.4	0.5	-0.7	-1.2	-0.7	0.1	-0.1	-0.1	0.8	0.4
Serious illness, injury or assault of a close relative in last 2 years	2.1	2.5	7.8	0.1	-1.8	-2.0	-2.0	0.7	-0.1	0.3	0.2	1.8	2.8	2.0
Mouth/teeth dental problems: Dentures	0.3	0.6	1.8	-0.1	-0.3	-0.2	-0.8	-0.5	1.3	1.0	1.2	-0.3	0.4	0.8
Asthma	0.3	0.6	2.1	-0.6	0.9	-1.4	0.4	1.4	-0.2	-0.4	-0.2	-0.9	0.1	0.0
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.8	3.3	1.1	0.3	-0.9	0.5	-1.8	-0.4	1.1	0.4	-0.4	-1.0	-1.0
Medication: Cholesterol lowering	0.2	0.4	1.1	-0.5	0.8	1.0	1.0	-0.4	-0.3	0.3	0.1	-0.3	-0.4	0.4
Depression (self-reported)	1.0	1.2	3.9	2.0	-0.3	0.3	0.8	1.8	1.0	0.8	0.9	0.7	1.1	0.8
Medication: Lansoprazole	1.9	2.2	4.6	1.6	2.1	-1.3	1.2	1.0	1.5	2.1	2.1	1.3	0.7	0.4
Prospective memory result	0.5	0.6	2.9	-1.1	0.7	0.5	0.7	-0.5	-0.7	0.2	0.1	-0.1	0.9	1.7
Lung cancer (father)	0.9	1.0	4.5	-0.9	2.1	0.3	0.5	1.7	1.3	0.4	0.8	0.4	0.1	0.2
Illnesses of mother	0.5	0.6	1.7	-0.8	-0.4	-0.4	0.3	-1.1	-0.2	-0.9	-0.7	-1.3	-0.7	-1.0
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.1	6.1	2.5	1.3	-0.5	1.9	-0.3	0.1	0.3	-0.0	2.3	2.1	1.1
Pulse wave Arterial Stiffness index	0.9	1.1	3.3	1.2	1.1	-0.7	0.6	-1.0	-0.0	0.5	0.4	1.8	1.0	1.7
Impedance of arm (left)	0.2	1.0	2.2	-0.2	0.0	-1.5	-0.5	-1.3	-1.2	-0.9	-0.9	-0.4	-1.1	-1.4
Arm fat mass (right)	0.4	1.5	4.9	1.5	1.2	-1.2	2.2	-0.1	0.7	0.2	0.5	1.2	1.2	1.8
Trunk predicted mass	0.5	2.6	7.0	1.3	0.8	-1.2	1.2	-2.6	2.6	1.4	1.4	0.6	1.7	1.7
Standing height	0.7	6.5	28.7	1.6	1.2	-2.1	1.7	-5.4	3.5	1.8	2.0	1.1	2.4	2.2
Length of working week for main job	0.5	0.6	2.7	1.0	0.2	-0.4	-0.1	-0.0	0.3	0.0	0.2	0.7	1.6	1.3
Exposure to tobacco smoke at home	0.8	0.9	3.9	-0.6	-0.8	-0.2	-0.4	-0.2	0.3	1.3	1.0	-2.0	-1.3	-0.4
Breastfed as a baby	0.4	0.5	1.3	0.7	0.8	-0.8	0.2	-0.2	0.6	0.4	0.3	1.1	1.1	0.9
Tense / ‘highly strung’	0.8	1.4	3.1	1.1	0.8	-0.1	1.3	1.2	1.1	1.8	1.4	0.5	1.6	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	2.0	0.6	0.0	-1.4	-0.5	-0.4	-0.1	0.4	-0.2	-1.3	-0.1	-0.9
Hair/balding pattern: Pattern 4	0.6	1.5	4.9	-1.8	-0.5	-0.5	-0.5	-0.5	-1.5	-1.2	-1.6	-2.2	-1.1	-0.5
Birth weight of first child	0.5	1.0	3.2	0.5	-1.4	1.2	-1.8	-0.8	0.5	0.2	0.3	0.6	1.2	1.1
Peak expiratory flow (PEF)	0.5	1.1	3.5	0.7	0.4	0.7	1.9	-0.8	-1.8	-1.1	-1.5	0.5	0.4	-0.3
Pulse wave reflection index	0.9	1.1	5.6	2.4	-0.8	-0.2	-0.6	0.9	0.4	-0.6	-0.2	2.0	0.3	-0.1
Ever highly irritable/argumentative for 2 days	0.6	0.7	2.4	1.0	-0.4	0.4	1.0	0.4	-0.8	-0.5	-0.5	1.5	1.2	0.8
Loud music exposure frequency	0.4	0.4	2.2	1.5	-0.7	-1.1	-0.0	0.1	-0.3	0.4	0.1	0.6	0.3	-0.0
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.9	0.7	-0.8	-0.2	-0.9	-0.9	0.2	-0.7	-0.6	0.7	0.7	0.1
Mouth/teeth dental problems: Bleeding gums	0.5	0.6	2.4	-1.4	0.4	-0.7	-0.3	-0.3	-0.5	0.2	-0.3	-1.6	-0.8	-0.9
Blood clot in the leg (DVT)	0.4	0.5	1.8	-0.1	1.0	-1.2	0.7	0.5	0.1	0.1	0.1	-1.3	-0.9	-0.1
Medication: Paracetamol	0.5	0.8	4.2	0.0	1.4	-2.0	0.8	-0.7	0.2	0.8	0.7	0.3	0.0	0.4
Headache pain in last month	2.0	3.4	10.9	-0.6	3.3	-1.9	1.2	-0.1	1.3	2.3	2.3	1.2	1.5	2.3
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	1.9	0.5	-0.5	-0.5	-1.0	1.2	1.3	1.1	1.3	0.4	1.4	0.2
Glaucoma (self-reported)	0.3	0.3	1.2	0.9	-0.0	-0.6	-0.4	-1.1	0.7	0.1	0.0	0.1	-0.2	-0.8
Gout (self-reported)	0.8	1.1	4.8	0.7	2.2	-0.7	1.8	1.1	-0.2	0.1	-0.0	1.0	0.6	0.5
Hypothyroidism/myxoedema (self-reported)	0.4	0.8	4.4	0.5	0.7	-0.3	0.9	2.1	-0.0	-0.8	-0.7	1.0	0.3	-0.3
Medication: Amlodipine	0.6	0.8	2.1	-1.4	-0.8	1.1	-1.4	-0.8	-0.2	-0.4	-0.6	-0.3	-0.8	-1.0
Medication: Ventolin 100micrograms inhaler	0.5	0.7	2.8	-1.7	0.6	-1.1	0.4	-1.1	0.3	0.2	0.2	-1.3	0.2	0.1
Birth weight	0.2	0.3	1.5	1.0	-0.2	-1.2	-0.4	-0.4	-0.4	-0.4	-0.4	-0.0	-0.0	-0.4
Chronic bronchitis/emphysema (mother)	1.2	1.3	3.0	1.0	1.0	0.3	1.0	0.3	1.4	0.5	1.1	1.6	1.7	1.5
High blood pressure (siblings)	0.5	0.7	2.5	-0.7	0.3	1.1	0.0	0.4	0.6	1.1	0.5	-1.6	-0.9	-1.0
Forced vital capacity (FVC), Best measure	0.5	1.7	4.0	2.0	1.8	-0.2	2.0	-0.6	0.1	0.4	0.0	1.8	1.8	0.8
Body fat percentage	0.3	1.1	4.8	0.8	1.4	-1.1	2.2	0.2	0.0	0.2	0.4	0.9	0.6	1.6
Leg fat percentage (right)	0.2	0.8	2.9	0.1	0.8	-0.1	1.4	1.7	-0.1	0.2	0.5	0.8	0.4	1.6
Arm fat-free mass (right)	0.8	4.3	8.2	1.8	1.3	-0.3	2.5	-2.8	2.9	1.9	1.9	1.4	2.4	2.3
Exposure to tobacco smoke outside home	0.4	0.5	2.3	-0.3	-0.8	-0.7	-0.4	-1.5	0.1	0.7	0.7	-0.6	-0.7	0.7
Comparative body size at age 10	0.3	0.8	4.6	-0.0	0.5	-1.1	-0.0	2.1	0.1	0.6	0.8	0.6	0.7	0.8
Number of full brothers	1.3	1.6	5.0	2.0	1.8	0.2	2.2	0.0	0.8	0.4	0.5	1.4	1.4	0.8
Worry too long after embarrassment	0.7	1.2	3.6	-1.6	0.7	-0.5	0.3	-1.9	0.5	1.4	0.9	-1.8	-0.4	0.2
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.6	1.7	1.0	0.1	-1.0	0.7	0.1	0.5	-0.1	0.2	1.1	1.3	0.8
Wheeze or whistling in the chest in last year	1.1	2.0	4.3	-1.2	0.8	0.2	1.0	1.2	-1.7	-2.1	-2.0	-1.9	-1.1	-1.2
Number of children fathered	0.7	0.8	5.6	0.6	-0.6	-2.4	0.6	0.0	0.1	-0.9	-0.5	0.2	0.4	0.6
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.3	0.9	0.9	-0.5	0.3	0.0	0.5	0.3	0.8	0.9	0.5	-0.3	0.0
Age at first live birth	1.4	2.5	5.1	-1.6	-0.6	-0.7	-0.0	-1.6	-2.0	-1.8	-2.2	-2.3	-1.4	-1.7
Pulse wave peak to peak time	0.8	1.0	3.4	-1.4	-1.1	0.6	-0.4	0.4	0.1	-0.6	-0.4	-1.8	-0.9	-1.5
Health satisfaction	0.8	1.0	2.2	0.5	-0.2	-1.4	0.4	-1.0	1.1	1.4	1.5	0.8	0.8	1.1
Shortness of breath walking on level ground	0.3	0.3	1.2	-0.8	-0.7	-0.2	-0.2	-1.1	0.1	0.5	0.5	-0.4	0.0	0.9
Qualifications: College or University degree	0.5	1.6	7.3	1.0	0.3	-0.0	-0.7	-0.8	1.7	2.7	2.2	-0.5	0.6	0.1
Eye problems/disorders: None of the above	0.5	0.6	1.6	1.3	-0.8	-1.0	-1.1	-0.4	0.6	-0.3	-0.2	1.1	0.7	-0.0
Mouth/teeth dental problems: Loose teeth	0.5	0.6	1.8	-0.8	1.4	-0.8	0.6	0.1	-0.2	0.2	-0.0	-1.1	-0.9	-1.1
Emphysema/chronic bronchitis	0.6	0.7	2.5	-0.6	1.3	-0.7	1.1	-1.6	-0.9	0.3	0.1	-0.1	0.4	0.7
Medication for pain relief, constipation, heartburn	0.6	1.0	3.2	-1.7	-1.6	0.5	-1.8	0.6	0.1	-1.0	-0.6	-0.6	-0.0	0.2
Neck or shoulder pain in last month	0.9	1.2	4.1	-0.4	1.3	0.8	2.0	0.4	-0.9	-1.6	-1.6	-0.8	-0.3	-0.4
Medication: Blood pressure	0.7	1.3	4.2	-0.3	-0.1	-0.3	0.3	-1.1	-1.6	-1.4	-1.6	-1.0	-2.1	-0.8
Angina (self-reported)	0.3	0.4	1.3	0.1	0.7	0.7	-0.0	0.4	-0.1	0.0	-0.2	-0.5	-1.2	-1.1
Migraine (self-reported)	0.8	1.0	3.0	-0.6	1.7	0.3	1.1	-0.1	-1.6	-1.2	-1.3	0.9	0.3	-0.2
Medication: Ibuprofen	0.8	0.9	3.5	1.3	-0.2	-0.6	-0.1	-1.9	0.1	1.3	0.8	0.2	-1.0	-1.1
Medication: Allopurinol	0.4	0.5	1.6	-0.0	1.0	-1.2	0.4	0.7	-0.0	-0.2	-0.3	1.3	0.7	0.3
Medication: Omeprazole	2.6	3.1	6.3	2.1	0.7	0.2	2.2	0.2	1.7	1.7	1.7	2.2	2.5	2.3
Medication: Seretide 50 evohaler	0.4	0.5	1.8	0.0	0.7	-1.3	1.1	-0.9	0.0	0.5	0.4	0.3	0.1	0.5
Mean time to correctly identify matches	0.3	0.6	3.3	-0.2	-1.4	0.3	-1.8	1.0	0.5	0.3	0.2	-0.1	-0.1	-0.5
Heart disease (mother)	0.8	0.9	5.2	0.4	0.1	0.1	-0.7	0.1	0.7	2.3	1.6	-1.1	-0.0	0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.8	0.9	3.0	1.7	0.3	1.4	0.4	1.3	1.1	0.6	0.7	1.0	0.2	0.1
Whole body fat mass	0.4	1.8	6.8	1.1	1.7	-1.4	2.6	-0.5	0.7	0.4	0.7	0.9	1.1	1.9
Leg fat mass (right)	0.4	1.5	5.8	0.8	1.4	-0.9	2.4	0.5	0.5	0.4	0.8	1.1	0.9	2.0
Arm predicted mass (right)	0.9	4.4	8.4	1.9	1.1	-0.5	2.4	-2.5	2.9	1.9	1.9	1.5	2.5	2.5
Pulse rate, automated reading	0.6	2.1	7.8	-1.1	2.1	-1.6	2.8	-1.9	-0.1	1.0	0.7	-1.1	-0.5	0.4
Alcohol intake frequency.	0.3	0.8	2.3	0.2	1.5	-0.5	0.4	1.4	-0.4	-0.4	-0.5	-0.7	-1.1	-1.4
Comparative height size at age 10	0.5	3.0	9.9	2.0	0.5	1.2	0.5	-2.2	3.1	1.3	1.9	1.2	1.4	1.9
Number of full sisters	1.5	1.9	4.7	-0.5	-0.4	-0.5	-2.0	0.4	-2.1	-2.2	-2.0	1.2	0.9	0.7
Suffer from ‘nerves’	0.3	0.5	2.1	0.4	-1.5	-0.7	-1.1	-0.7	-0.2	0.6	0.4	-0.9	0.3	0.5
Overall health rating	0.5	1.1	3.5	0.7	1.9	-0.0	1.8	-0.4	-0.9	-0.3	-0.3	0.3	-1.6	-0.8
Chest pain or discomfort	0.5	0.8	3.9	0.5	1.3	1.4	2.0	-0.6	-0.0	-0.0	0.1	-0.3	0.2	0.5
Had major operations	0.4	0.5	1.6	-0.3	0.8	-1.3	1.2	-0.1	-0.3	-0.0	-0.1	-0.6	-1.1	-0.6
Age at last live birth	0.4	0.6	2.7	-0.3	0.5	0.9	0.3	-1.0	-1.6	-0.7	-1.1	-0.3	-0.1	-0.4
Family relationship satisfaction	0.9	1.1	10.4	0.2	-0.9	-3.2	0.2	-0.8	-0.2	-0.2	-0.5	-0.3	0.5	0.1
Leg pain on walking	1.1	1.4	4.1	-2.0	0.6	-0.8	0.9	-1.3	0.6	1.2	1.3	-1.7	-1.3	0.0
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.3	1.4	0.3	-0.8	-1.0	0.4	-1.2	-0.0	-0.0	-0.1	-0.3	-0.1	-0.1
Commuting to job workplace: Car/motor vehicle	0.3	0.3	0.9	-0.5	-0.9	0.1	-0.4	-0.8	-0.5	-0.8	-0.5	-0.3	0.1	0.7
Illness, injury, bereavement, stress in last 2 years	1.9	2.3	9.2	-1.1	2.1	0.4	3.0	-1.0	0.0	0.4	0.1	-2.4	-1.5	-1.2
Medication: Aspirin	0.9	1.2	2.1	1.3	1.2	0.9	1.5	0.4	1.1	1.1	1.3	1.1	0.8	1.1
Supplements: Vitamin C	0.4	0.5	1.6	-0.1	0.2	-0.8	-0.9	-0.2	-1.3	-0.8	-1.1	-0.6	-0.4	-0.6
Knee pain experienced in last month	0.3	0.4	1.7	0.8	-0.6	-0.3	0.5	-1.3	-0.5	0.1	-0.1	-0.8	-0.9	-0.4
Hypertension (Self-reported)	0.9	2.5	14.7	-0.4	3.0	-0.4	3.8	-0.8	0.0	0.6	0.6	0.0	-1.3	-0.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.0	2.4	9.0	0.9	1.1	0.4	1.4	0.2	0.5	0.8	0.9	2.1	3.0	2.5
Illnesses of father: Heart disease	0.6	0.9	2.9	-0.1	1.7	0.6	-0.0	1.0	1.0	1.2	1.2	-1.0	-0.5	-0.6
Illnesses of siblings: Diabetes	1.9	2.3	6.3	-0.6	-0.2	-0.5	-2.5	1.5	1.9	1.0	1.6	1.0	2.0	2.1
Smoking status: Previous	0.8	1.2	4.8	-1.9	-0.5	-1.6	-2.2	-0.4	-0.5	-0.1	0.1	-0.7	-0.8	1.0
Forced expiratory volume in 1-second (FEV1), predicted	0.8	1.7	7.2	1.3	1.3	-1.4	1.1	-2.7	1.3	0.5	0.3	1.0	1.2	0.5
Whole body fat-free mass	0.6	3.2	6.9	1.9	1.1	-1.2	2.0	-2.6	2.6	1.4	1.4	0.9	1.8	1.7
Leg fat-free mass (right)	0.7	3.5	6.6	2.3	1.5	-1.7	2.6	-2.4	2.4	1.4	1.4	0.8	1.6	1.5
Arm fat percentage (left)	0.2	0.9	3.2	0.7	1.2	-1.5	1.8	0.5	-0.3	-0.1	0.0	0.6	0.3	1.1
Average weekly red wine intake	0.7	1.0	3.3	0.5	0.3	-0.4	-1.8	1.2	1.0	0.8	0.8	1.2	1.3	0.6
Handedness (chirality/laterality): Left-handed	0.4	0.5	1.4	-0.6	0.3	-0.8	-0.2	-0.7	1.2	0.8	0.7	-0.9	-0.3	-0.8
Mood swings	0.4	0.7	2.9	1.3	1.7	-0.5	1.0	-0.2	0.6	0.9	0.5	0.2	0.1	-0.4
Loneliness, isolation	0.3	0.3	0.8	0.5	-0.7	0.3	-0.4	-0.9	0.2	0.9	0.6	-0.6	0.6	0.5
Long-standing illness, disability or infirmity	0.4	0.7	2.6	1.6	0.7	0.4	0.6	1.0	1.4	-0.6	-0.0	0.3	-0.3	-0.6
Ever had bowel cancer screening	2.4	2.8	9.3	-0.9	-1.0	0.5	-0.2	-0.7	-0.9	-1.3	-1.3	-2.6	-3.0	-2.9
Diabetes diagnosed by doctor	0.5	0.9	1.8	1.3	-1.3	-0.9	-1.0	0.8	0.8	0.4	0.5	1.4	0.9	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.7	0.8	3.8	0.7	-0.0	-0.1	0.8	-0.5	-2.0	-0.9	-1.4	-0.2	0.8	-0.2
Friendships satisfaction	1.2	1.4	5.2	0.0	-0.2	-1.2	0.0	-0.2	1.7	2.3	2.2	0.2	0.6	1.1
Qualifications: nursing, teaching	0.4	0.6	1.8	0.2	1.3	0.7	1.1	0.2	-0.8	-1.1	-1.0	0.7	0.5	-0.1
Commuting to job workplace: Walk	1.6	1.8	3.1	1.5	1.2	-1.7	0.1	1.1	1.0	1.6	1.3	1.6	1.8	0.8
Eye problems/disorders: Cataract	2.1	2.4	4.8	-1.2	2.1	1.6	2.2	2.1	1.1	1.8	2.0	-0.1	-0.6	0.2
Mouth/teeth dental problems: Mouth ulcers	0.6	0.9	3.8	-1.9	0.7	0.2	0.0	-0.3	-1.4	-0.8	-1.0	-1.2	-0.8	-0.1
Medication for cholesterol	1.2	1.9	10.4	-0.3	-2.3	0.1	-3.2	-1.5	0.2	0.4	0.2	-0.4	0.9	1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	1.2	0.8	1.1	0.5	0.4	0.1	-0.4	-0.7	-0.4	0.9	-0.1	-0.3
Back pain experienced in last month	1.4	2.0	12.5	0.4	0.8	-1.9	1.5	-3.5	0.0	1.3	1.0	-0.1	-0.2	0.6
Mineral and other dietary supplements	0.2	0.3	1.7	-0.1	-0.4	-1.3	0.6	0.4	0.6	-0.3	-0.1	0.2	0.9	0.4
Breast cancer (self-reported)	1.8	2.1	4.8	0.9	-0.3	1.4	-1.1	2.2	1.7	1.4	1.9	1.1	1.3	1.6
Asthma (self-reported)	0.3	0.5	2.2	-0.6	0.7	-1.5	0.2	1.4	0.1	-0.3	-0.2	-0.9	0.3	0.2
Osteoporosis (self-reported)	0.4	0.5	2.9	-0.4	0.9	0.2	1.7	-1.3	-0.0	0.2	-0.1	0.0	0.1	-0.5
Osteoarthritis (self-reported)	0.5	0.7	2.5	1.6	-0.2	-1.1	0.2	0.6	0.9	0.4	0.7	1.0	0.4	0.6
Medication: Aspirin	1.2	1.6	2.8	1.2	1.3	1.1	1.4	0.7	1.4	1.5	1.7	1.2	0.6	1.2
Medication: Gliclazide	2.0	2.2	7.2	2.0	0.1	-0.6	-0.2	-0.5	1.6	2.7	2.2	1.1	1.6	1.4
Illnesses of father: None of the above (group 1)	1.9	2.3	9.1	0.6	-3.0	-1.2	-2.6	-0.4	-1.6	-1.4	-1.7	0.2	-0.2	-0.4
Smoking status: Current	0.5	0.8	2.3	1.0	0.1	-0.4	1.4	-0.8	1.5	0.1	0.3	0.9	1.1	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.9	-0.2	0.5	1.0	1.2	1.4	-1.0	0.0	-0.3	0.0	-0.1	0.3
Whole body water mass	0.6	3.3	7.2	2.0	1.1	-1.1	2.0	-2.6	2.7	1.4	1.5	1.0	1.9	1.9
Leg predicted mass (right)	0.7	3.6	6.8	2.3	1.5	-1.7	2.6	-2.5	2.5	1.4	1.5	0.9	1.6	1.6
Arm fat mass (left)	0.4	1.5	4.9	1.5	1.2	-1.2	2.2	0.1	0.8	0.2	0.6	1.1	1.1	1.7
Number of self-reported non-cancer illnesses	0.7	1.1	3.2	-0.3	1.8	0.6	1.7	1.1	0.2	-0.1	-0.2	-0.9	-1.3	-1.4
Average weekly champagne plus white wine intake	0.4	0.6	1.8	1.4	-0.3	-0.6	-0.9	-0.9	0.2	-0.6	-0.4	1.2	0.5	-0.4
Miserableness	0.5	0.9	4.1	0.6	0.5	0.3	0.1	0.5	0.9	2.0	1.6	-1.0	-0.3	-0.3
Guilty feelings	0.3	0.5	1.5	-0.4	0.9	-1.2	0.0	-1.1	-0.4	0.9	0.3	-0.8	0.2	-0.0
Wears glasses or contact lenses	0.4	0.4	1.5	-1.2	-0.3	1.0	0.2	1.1	0.2	-0.4	-0.1	-0.7	-0.1	0.4
Ever taken oral contraceptive pill	1.0	1.2	4.5	-0.3	-1.4	-2.1	-1.1	-1.3	-1.0	-1.1	-1.1	-0.3	-0.0	-0.0
Hearing aid user	0.7	0.8	3.2	-0.1	0.1	-0.9	1.0	-0.8	-1.8	-0.8	-1.1	0.2	0.1	0.9
Mother’s age at death	2.3	2.8	9.6	-1.1	-2.5	2.9	-3.1	-0.1	-0.9	-0.3	-0.5	-1.6	-1.3	-0.4
Financial situation satisfaction	1.2	1.4	3.3	0.7	0.3	-1.4	1.0	0.6	0.4	0.9	1.0	1.8	1.8	1.8
Tinnitus: Yes, now most or all of the time	2.1	2.5	6.7	0.1	-1.9	-2.1	-0.9	-1.9	-0.6	-2.6	-2.3	-1.0	-0.8	-0.9
Commuting to job workplace: Public transport	0.5	0.6	1.7	-1.1	0.7	-0.8	-0.3	0.1	-0.4	0.7	0.1	-1.0	-1.3	-1.0
Eye problems/disorders: Glaucoma	0.2	0.3	1.5	0.6	-0.0	-0.3	-0.3	-1.2	-0.4	-0.4	-0.4	0.5	0.3	-0.3
Medication: Blood pressure	1.8	3.3	21.5	0.2	3.1	0.1	4.6	0.8	1.1	1.3	1.3	0.7	0.3	0.1
Pain type(s) experienced in last month: Hip pain	0.3	0.3	1.0	-0.0	-0.7	-0.7	-0.7	-0.9	0.2	-0.1	0.0	0.2	0.7	1.0
Supplements: Fish oil (including cod liver oil)	0.4	0.5	3.2	0.4	0.3	1.8	-1.0	0.3	-0.5	-0.4	-0.4	0.4	-0.4	-0.2
High cholesterol (Self-reported)	0.4	0.7	4.0	-0.9	0.9	2.0	0.4	-0.2	0.1	0.3	0.0	-0.7	-0.7	-1.1
Medication: Bendroflumethiazide	0.8	1.2	5.7	-1.0	0.7	0.5	2.4	1.8	0.5	-0.6	-0.5	-0.9	-0.7	0.2
Medication: Paracetamol	0.7	1.1	5.4	0.7	1.1	-2.3	0.8	-0.9	0.2	1.3	1.1	0.9	0.3	0.6
Medication: Lisinopril	0.5	0.6	1.7	1.1	0.7	0.2	1.3	1.3	-0.5	-0.3	-0.5	1.1	0.6	0.0
Medication: Atorvastatin	0.2	0.3	1.3	-0.7	-0.3	0.3	0.4	0.4	-0.0	0.5	0.4	-0.1	0.5	1.1
Illnesses of father: High blood pressure	0.9	1.1	4.5	0.4	2.1	0.6	1.8	-0.4	0.8	1.0	1.0	0.6	0.6	0.6
Alcohol drinker status: Never	1.2	1.4	2.7	1.6	-1.0	-1.1	-1.5	1.3	1.4	1.3	1.5	0.7	0.5	0.9
Ever smoked	0.6	1.0	5.0	-0.1	-0.8	-2.0	-2.2	-0.7	0.8	-0.3	-0.0	0.2	0.2	0.4
Basal metabolic rate	0.6	3.4	6.7	2.1	1.2	-1.3	2.1	-2.2	2.6	1.4	1.5	1.2	2.0	2.0
Leg fat percentage (left)	0.2	0.8	2.8	-0.3	0.9	0.1	1.5	1.4	-0.1	0.2	0.5	0.5	0.3	1.7
Arm fat-free mass (left)	0.7	3.6	8.2	1.8	1.0	-0.3	2.2	-1.9	2.9	1.6	1.8	1.3	2.3	2.5
Number of operations (self-reported)	0.5	0.7	2.1	1.4	0.2	-0.1	0.8	-0.2	-1.4	-1.1	-1.1	-0.2	-0.6	-0.3
Average weekly beer plus cider intake	1.0	1.4	4.0	-0.9	1.2	-0.8	2.0	1.0	-1.5	-1.2	-1.3	-1.2	-0.8	-0.4
Irritability	0.3	0.5	1.8	1.1	0.3	0.6	0.3	-0.2	0.8	1.4	0.9	0.4	0.5	-0.3
Risk taking	1.5	2.1	10.7	0.0	1.3	-3.3	1.3	-2.6	-0.6	-1.0	-0.9	0.7	0.2	0.3
Ever had prostate specific antigen (PSA) test	0.6	0.7	2.5	0.6	-0.3	0.3	-1.5	0.1	0.1	1.6	1.0	-1.1	0.2	0.6
Fractured/broken bones in last 5 years	1.1	1.4	2.9	1.7	1.4	1.3	1.4	-0.8	0.9	0.9	1.1	1.2	1.1	1.1
Age started oral contraceptive pill	0.8	1.0	3.6	-1.9	0.6	0.6	1.0	-1.0	0.6	1.0	0.8	-1.4	0.0	1.0
Diastolic blood pressure, automated reading	0.4	1.2	5.0	1.1	0.9	2.2	1.4	1.1	-0.6	-0.2	-0.1	1.1	0.7	0.9
Ever depressed for a whole week	1.4	1.7	7.4	1.2	-2.7	-0.6	-1.9	2.1	0.0	0.5	0.3	-1.1	-0.3	-0.3
Unable to work because of sickness or disability	1.0	1.3	2.9	1.7	1.0	-0.9	0.6	1.3	1.5	1.6	1.5	0.1	-0.4	-0.1
Commuting to job workplace: Cycle	0.9	1.0	4.1	0.3	2.0	-0.8	1.4	0.5	1.3	0.4	0.6	1.1	0.9	0.5
Myopia	0.3	0.4	1.1	0.2	0.1	-0.2	1.0	-0.8	0.1	-0.9	-0.9	-0.4	-0.4	-0.9
Vascular/heart problems diagnosed by doctor	0.9	2.4	14.4	-0.8	-2.6	-0.9	-3.8	0.8	-0.1	-0.4	-0.3	-0.0	1.6	0.7
Cholesterol lowering medication	0.6	0.9	5.0	0.2	0.6	2.2	0.7	1.3	0.6	0.2	0.3	0.0	-0.6	-1.2
Medication: Omeprazole (e.g. Zanprol)	1.5	1.8	3.8	1.5	1.0	-0.0	1.6	-0.3	1.2	1.1	1.4	1.6	1.6	1.9
Pain experienced in last month	0.8	1.3	5.4	0.5	-0.3	1.3	-0.1	2.3	0.8	0.2	0.5	1.5	1.7	0.6
Supplements: Calcium	1.5	1.6	8.0	-0.4	-1.3	-1.5	-1.3	-2.8	-0.7	-0.7	-0.7	-0.6	-1.2	-0.9
Basal cell carcinoma (self-reported)	1.9	2.3	4.7	1.9	-0.7	-0.8	-0.5	1.0	2.2	1.8	2.1	1.7	1.8	0.9
Heart attack/myocardial infarction (self-reported)	1.6	2.1	5.4	2.3	0.0	1.0	1.9	-1.6	-1.1	-0.8	-1.3	-0.8	-1.7	-1.9
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	2.2	-0.1	1.0	-1.1	0.6	0.5	0.4	0.5	0.5	-1.5	-0.9	-0.1
Heart disease (siblings)	0.7	0.8	2.9	0.5	-0.3	1.6	-1.4	1.7	-0.3	-0.5	-0.6	0.5	-0.0	-0.7
Alcohol drinker status: Previous	0.8	0.9	5.6	0.8	2.4	-1.0	0.8	-0.7	0.7	0.8	0.6	0.3	0.5	-0.1
Pack years of smoking	0.8	1.1	4.2	1.3	1.0	-1.0	0.1	-2.1	0.5	1.0	0.8	1.1	0.8	1.0
Impedance of whole body	0.1	0.5	1.1	-0.8	-0.2	-0.3	-0.6	-0.6	-1.1	-0.9	-0.7	0.2	-0.7	-1.0
Leg fat mass (left)	0.3	1.4	5.7	0.6	1.4	-0.8	2.4	0.3	0.5	0.4	0.7	1.0	0.8	1.9
Arm predicted mass (left)	0.7	3.6	8.2	1.8	1.1	-0.5	2.3	-2.1	2.9	1.5	1.7	1.3	2.3	2.3