TWAS hub - FANCI

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Testis	0.188	0.082	0.0040	0.038	NA	0.085	NA	0.055	0.0087	NA	0.00013	NA	0.0018
2	TCGA	Bladder Urothelial Carcinoma	0.076	0.042	0.0035	0.000	0.022	0.004	NA	0.000	0.3400	0.0052	0.13000	NA	0.3300

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Ever had bowel cancer screening	6.1	7.1	12.5	-3.5	1.4
Emphysema/chronic bronchitis	5.0	5.7	6.1	-2.3	2.5
Ever used hormone-replacement therapy (HRT)	4.7	5.9	10.7	1.1	-3.3
Height	4.5	87.4	163.8	-12.8	3.3
Birth weight of first child	4.4	7.9	8.1	-2.8	2.8
Bilateral oophorectomy (both ovaries removed)	4.3	5.0	6.9	-2.6	1.8
Ever depressed for a whole week	4.3	5.3	5.4	-2.3	2.3
Headache pain in last month	4.2	7.2	9.0	3.0	-2.3
Eye problems/disorders: Diabetes related eye disease	4.1	4.5	6.4	-1.6	2.5
Qualifications: CSEs or equivalent	4.0	5.3	7.2	2.7	-1.9
Standing height	4.0	39.3	72.1	-8.5	2.5
Comparative body size at age 10	3.9	10.7	21.1	4.6	-0.5
Medication: Lansoprazole	3.8	4.4	5.9	1.7	-2.4
Ever smoked	3.8	6.6	7.1	-2.7	2.5
Serious illness, injury or assault to yourself	3.6	4.4	6.4	-1.6	2.5
Pack years of smoking	3.6	5.3	7.5	2.7	-1.8
Past tobacco smoking	3.5	6.5	8.0	2.8	-2.2
Breastfed as a baby	3.5	4.4	5.9	-2.4	1.7
Sitting height	3.4	24.1	45.8	-6.8	1.5
Comparative height size at age 10	3.2	17.4	31.5	-5.6	1.8
Smoking Status	3.1	7.3	9.8	-3.1	2.2
Pack years adult smoking proportion	3.1	4.8	7.3	2.7	-1.5
Had menopause	3.0	3.8	5.6	1.4	-2.4
Ovarian Cancer	2.9	3.9	7.2	0.8	-2.7
Number of full sisters	2.9	3.5	6.7	-2.6	0.5
Medication: Omeprazole (e.g. Zanprol)	2.8	3.4	5.4	1.2	-2.3
Supplements: Zinc	2.7	2.9	5.6	-2.4	0.5
Health satisfaction	2.7	3.5	4.3	2.1	-1.6
Medication: Ibuprofen	2.6	3.1	6.2	2.5	-0.4
Medication: Ibuprofen (e.g. Nurofen)	2.4	3.1	6.1	2.5	-0.2
Handedness (chirality/laterality): Left-handed	2.4	2.8	4.8	-0.9	2.2
Age started oral contraceptive pill	2.4	2.9	5.8	-2.4	-0.3
Smoking status: Previous	2.3	3.4	3.5	-1.9	1.8
Medication: Simvastatin	2.2	3.2	6.2	0.5	-2.5
Number of children fathered	2.1	2.4	2.4	-1.5	1.5
Illnesses of father: High blood pressure	2.1	2.6	2.9	1.7	-1.5
Alzheimer’s Disease (including proxy)	2.0	2.9	4.5	-1.2	2.1
Frequency of depressed mood in last 2 weeks	2.0	2.8	5.5	2.4	-0.3
Trunk predicted mass	2.0	11.4	12.8	-3.6	3.2
Mean time to correctly identify matches	2.0	3.8	5.0	-1.6	2.2
Qualifications: NVQ or HND or HNC or equivalent	2.0	2.5	3.2	1.8	-1.3
Medication for cholesterol	2.0	3.1	3.8	-1.5	2.0
High blood pressure (mother)	1.9	2.6	3.5	1.9	-1.3
Trunk fat-free mass	1.9	11.2	12.8	-3.6	3.1
Alcohol intake versus 10 years previously	1.8	2.7	4.0	-2.0	1.2
Hair/balding pattern: Pattern 3	1.8	2.7	5.1	2.3	-0.6
Number of live births	1.8	2.6	3.3	1.8	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.8	2.4	4.5	2.1	0.5
Eye problems/disorders: Cataract	1.8	2.1	3.7	1.9	-0.8
Relative age voice broke	1.7	2.6	4.2	-1.0	2.0
Medication for pain relief, constipation, heartburn	1.7	2.9	3.0	-1.7	1.7
Medication: Omeprazole	1.7	2.0	3.3	0.9	-1.8
Mouth/teeth dental problems	1.6	2.5	3.6	1.2	-1.9
Had major operations	1.6	1.8	3.2	0.7	-1.8
Supplements: Vitamin C	1.6	1.9	3.5	-1.9	0.5
Hearing difficulty/problems with background noise	1.5	2.3	3.2	-1.8	1.2
Length of working week for main job	1.5	1.6	1.8	1.2	1.3
Illnesses of father: None of the above (group 1)	1.5	1.8	3.6	-1.9	0.2
Pulse rate	1.4	2.3	4.2	-0.6	2.1
Worry too long after embarrassment	1.4	2.4	4.8	2.2	-0.1
Loneliness, isolation	1.4	1.9	3.8	1.9	0.0
Financial situation satisfaction	1.4	1.8	2.9	1.7	-0.8
Pain type(s) experienced in last month: Hip pain	1.4	1.8	2.8	-1.7	0.9
Alzheimer’s Disease (in father)	1.3	1.4	2.0	-0.9	1.4
Whole body fat-free mass	1.3	7.7	8.1	-2.7	2.8
Qualifications: nursing, teaching	1.3	1.9	3.4	1.8	-0.7
Whole body water mass	1.3	7.5	8.1	-2.6	2.9
Wears glasses or contact lenses	1.3	1.5	2.7	-1.7	0.5
Alzheimer’s Disease (in mother)	1.2	1.4	2.4	-0.6	1.6
Major Depression (MDD)	1.2	1.4	2.8	0.1	-1.7
Rheumatoid Arthritis	1.2	1.7	3.1	0.5	-1.8
Medication: Cholesterol lowering	1.2	1.8	2.4	1.1	-1.6
Prospective memory result	1.2	1.4	2.8	0.3	-1.7
Suffer from ‘nerves’	1.2	1.8	3.5	1.9	-0.3
Medication: Blood pressure	1.2	2.3	4.1	0.7	-2.0
Medication: Lisinopril	1.2	1.5	3.0	0.3	-1.7
Arm predicted mass (left)	1.2	5.9	6.8	-2.2	2.6
Blood Platelet Count	1.1	12.3	16.6	2.8	-4.1
Medication: Seretide 50 evohaler	1.1	1.2	2.0	0.7	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.1	2.4	3.6	-1.1	1.9
Medication: Paracetamol	1.1	1.8	3.1	1.8	-0.7
Basal metabolic rate	1.1	6.1	6.3	-2.4	2.5
Arm fat-free mass (left)	1.1	5.6	6.6	-2.1	2.6
Number of operations (self-reported)	1.1	1.6	3.2	-1.8	-0.0
Supplements: Calcium	1.1	1.2	2.5	-1.6	-0.0
Impedance of leg (right)	1.0	4.7	8.3	-2.9	-1.1
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.3	-1.5	-0.3
Mouth/teeth dental problems: Dentures	1.0	1.6	1.9	-1.4	1.2
Medication: Paracetamol	1.0	1.6	1.6	1.3	-1.3
Average weekly red wine intake	1.0	1.5	1.6	-1.3	1.2
Ever taken oral contraceptive pill	1.0	1.1	1.6	0.7	-1.3
Myopia	1.0	1.5	3.0	-1.7	-0.0
Reaction Time	0.9	1.7	2.7	-0.9	1.6
Fasting Glucose	0.9	1.1	1.3	0.9	-1.2
Lung FVC	0.9	4.6	5.6	1.9	-2.4
Maternal smoking around birth	0.9	1.3	2.4	-0.4	-1.6
Impedance of leg (left)	0.9	4.2	6.0	-2.5	-1.5
Ever unenthusiastic/disinterested for a whole week	0.9	1.0	1.9	-1.4	0.4
Tense / ‘highly strung’	0.9	1.5	1.8	1.1	-1.3
Shortness of breath walking on level ground	0.9	1.0	1.3	0.9	-1.1
Mouth/teeth dental problems: Loose teeth	0.9	1.1	2.2	1.5	-0.0
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.9	1.1	1.9	1.4	-0.5
Chest pain or discomfort	0.9	1.3	2.5	-1.6	0.2
Impedance of whole body	0.9	4.7	6.5	-2.5	-1.7
Neuroticism (Nagel 2018)	0.8	2.0	2.6	1.6	-1.2
Body Mass Index (BMI) (2010)	0.8	1.1	2.1	1.5	-0.2
Leg fat-free mass (left)	0.8	4.0	5.3	-1.6	2.3
Heel bone mineral density (BMD) T-score, automated (left)	0.8	1.9	3.6	0.5	1.9
Body mass index (BMI)	0.8	3.3	6.3	2.5	0.6
Impedance of arm (right)	0.8	3.5	6.5	-2.5	-0.7
Father’s age at death	0.8	1.1	1.2	-1.0	1.1
Impedance of arm (left)	0.8	3.6	5.4	-2.3	-1.3
High blood pressure (siblings)	0.8	1.2	2.3	0.2	-1.5
Arm fat-free mass (right)	0.8	4.2	4.8	-1.9	2.2
Medication: Allopurinol	0.8	1.1	1.4	0.9	-1.2
Arm predicted mass (right)	0.8	4.3	5.1	-1.9	2.3
Family relationship satisfaction	0.8	1.0	1.5	1.2	0.7
Commuting to job workplace: Car/motor vehicle	0.8	0.9	1.8	-1.3	0.0
Mouth/teeth dental problems: Mouth ulcers	0.8	1.3	1.8	-0.9	1.3
Medication: Aspirin	0.8	1.1	1.3	-0.9	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	2.2	1.5	-1.1
Alcohol drinker status: Never	0.8	0.9	1.8	-1.3	0.4
Unable to work because of sickness or disability	0.8	1.0	1.2	0.9	1.1
Depression (Nagel 2018)	0.7	1.0	1.3	1.1	-0.9
Schizophrenia (2018)	0.7	1.4	1.6	-1.3	-1.1
Lupus	0.7	1.1	2.1	-0.3	-1.5
Medication for hormone replacement therapy	0.7	0.8	1.6	1.2	-0.3
Leg predicted mass (left)	0.7	3.9	5.3	-1.6	2.3
Nervous feelings	0.7	1.4	2.3	1.5	-0.7
Hair/balding pattern: Pattern 2	0.7	0.9	1.8	-1.4	-0.1
Forced expiratory volume in 1-second (FEV1)	0.7	2.4	3.6	1.1	-1.9
Pulse wave Arterial Stiffness index	0.7	0.8	1.4	-1.2	0.5
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.7	1.3	0.2
Neck or shoulder pain in last month	0.7	1.0	1.9	1.4	-0.4
Medication: Aspirin	0.7	1.0	1.3	-0.8	-1.2
Illnesses of siblings: Diabetes	0.7	0.8	1.4	0.4	-1.2
Commuting to job workplace: Cycle	0.7	0.9	1.8	-0.0	1.3
Type 2 Diabetes (T2D) (2018)	0.6	1.1	1.2	-1.1	1.0
Fed-up feelings	0.6	1.1	1.8	1.4	-0.6
Heart attack	0.6	0.8	1.2	1.1	-0.7
Medication: Ramipril	0.6	0.7	1.5	0.1	-1.2
Asthma	0.6	1.2	1.5	-1.2	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	0.9	-1.0	0.9
Pulse rate, automated reading	0.6	1.9	3.4	-0.6	1.8
Illnesses of father: Heart disease	0.6	0.8	1.3	1.1	0.6
Ever had stillbirth, spontaneous miscarriage or termination	0.6	0.6	1.0	-1.0	0.5
Osteoporosis (self-reported)	0.6	0.7	1.0	-1.0	-0.7
Smoking status: Current	0.6	1.0	1.1	-1.0	1.0
Leg predicted mass (right)	0.6	3.1	4.3	-1.4	2.1
Medication: Bendroflumethiazide	0.6	1.0	1.3	0.8	-1.1
Risk taking	0.6	0.9	1.5	1.2	-0.6
Fractured/broken bones in last 5 years	0.6	0.7	0.9	0.7	-0.9
Pain experienced in last month	0.6	1.0	1.6	-1.2	0.6
Primary Biliary Cirrhosis	0.5	0.8	0.8	0.9	-0.9
Medication: Metformin	0.5	0.7	0.8	-0.9	0.7
Diabetes (father)	0.5	0.7	0.9	1.0	-0.6
Medication: Levothyroxine sodium	0.5	0.9	1.6	0.5	1.2
Diabetes (self-reported)	0.5	0.8	1.0	-0.8	1.0
Illnesses of siblings	0.5	0.7	1.1	-0.5	1.0
Depression (self-reported)	0.5	0.6	0.7	0.8	0.7
Loud music exposure frequency	0.5	0.5	0.7	0.5	-0.9
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.0	0.4	-1.0
Qualifications: College or University degree	0.5	1.7	2.1	-1.1	1.4
Age at last live birth	0.5	0.7	1.2	-1.1	0.4
Leg fat-free mass (right)	0.5	2.9	3.8	-1.4	2.0
Diabetes diagnosed by doctor	0.5	0.8	0.9	-0.8	1.0
Back pain experienced in last month	0.5	0.8	0.8	0.9	-0.9
Breast cancer (self-reported)	0.5	0.6	0.8	0.9	-0.6
Asthma (self-reported)	0.5	1.1	1.1	-1.0	1.0
Osteoarthritis (self-reported)	0.5	0.6	1.2	0.1	-1.1
Commuting to job workplace: Public transport	0.5	0.6	1.2	1.1	0.2
Eye problems/disorders: Glaucoma	0.5	0.7	1.0	-1.0	0.6
Diastolic blood pressure, automated reading	0.5	1.6	2.6	-0.8	1.6
Heart attack/myocardial infarction (self-reported)	0.5	0.6	1.0	1.0	-0.5
Prostate Cancer	0.4	0.5	0.9	0.9	0.4
Age at First Birth	0.4	0.6	1.2	-1.1	0.2
Bipolar Disorder (2011)	0.4	0.4	0.9	0.9	0.0
HbA1C	0.4	0.5	0.9	0.1	-1.0
HDL Cholesterol	0.4	0.6	1.2	1.1	-0.1
Type 2 Diabetes (T2D) (2012)	0.4	0.4	0.8	0.9	0.2
Blood Red Count	0.4	4.3	8.4	-0.4	2.9
Lung FEV1/FVC ratio	0.4	2.0	3.5	1.9	0.7
Average weekly spirits intake	0.4	0.4	0.7	-0.5	0.8
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.5	0.6	0.8	0.7
Age when periods started (menarche)	0.4	1.0	2.0	-0.0	-1.4
Medication: Atenolol	0.4	0.5	0.9	0.0	-1.0
Number of incorrect matches in round	0.4	0.6	0.9	0.6	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.4	1.0	1.6	1.3	0.6
Qualifications: None of the above	0.4	0.8	1.2	-1.1	0.6
Pain all over the body in last month	0.4	0.4	0.5	0.7	-0.5
Weight	0.4	2.0	2.3	-1.3	1.5
Time employed in main current job	0.4	0.5	0.7	-0.5	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.4	0.7	1.3	1.2	-0.2
Lung cancer (father)	0.4	0.4	0.6	0.8	0.5
Forced expiratory volume in 1-second (FEV1), Best measure	0.4	1.3	1.4	1.2	-1.1
Peak expiratory flow (PEF)	0.4	1.0	1.6	0.6	-1.3
Ever highly irritable/argumentative for 2 days	0.4	0.5	0.8	0.9	0.5
Gout (self-reported)	0.4	0.6	1.0	0.3	-1.0
Number of full brothers	0.4	0.5	0.6	0.6	-0.8
Mood swings	0.4	0.8	1.4	1.2	0.4
Number of self-reported non-cancer illnesses	0.4	0.6	1.0	-1.0	0.6
Hearing aid user	0.4	0.4	0.7	0.3	0.9
Cholesterol lowering medication	0.4	0.6	0.8	-0.9	-0.6
Bipolar Disorder (2018)	0.3	0.6	1.0	0.2	1.0
Depressed Affect (Nagel 2018)	0.3	0.6	0.6	0.8	-0.7
Intelligence (Savage-Jansen 2018)	0.3	0.9	1.6	-1.3	0.5
Schizophrenia (2014)	0.3	0.7	1.3	-1.1	-0.2
Ulcerative Colitis	0.3	0.4	0.6	-0.4	-0.8
BMI	0.3	1.9	2.1	1.4	1.3
Number of treatments/medications taken	0.3	0.5	1.0	1.0	-0.3
Other serious medical condition/disability diagnosed by doctor	0.3	0.4	0.7	0.3	0.9
Systolic blood pressure, automated reading	0.3	0.9	1.6	-1.3	0.5
Severe depression (siblings)	0.3	0.4	0.7	-0.8	0.0
Hand grip strength (right)	0.3	0.7	1.3	1.1	-0.4
Townsend deprivation index at recruitment	0.3	0.4	0.7	0.8	-0.3
Current tobacco smoking	0.3	0.4	0.6	-0.5	0.8
Average weekly fortified wine intake	0.3	0.4	0.7	-0.8	-0.2
Taking other prescription medications	0.3	0.4	0.7	0.4	-0.8
Tinnitus: Yes, but not now, but have in the past	0.3	0.3	0.6	0.8	0.3
Supplements: Glucosamine	0.3	0.4	0.7	0.8	-0.5
Alcohol usually taken with meals	0.3	0.5	0.6	-0.8	0.6
Forced vital capacity (FVC)	0.3	1.1	2.2	-0.2	-1.5
Fluid intelligence score	0.3	0.6	1.1	-0.3	-1.1
Falls in the last year	0.3	0.4	0.8	-0.0	0.9
Illnesses of mother	0.3	0.4	0.6	-0.3	0.8
Hair/balding pattern: Pattern 4	0.3	0.6	1.3	-0.1	1.1
Birth weight	0.3	0.7	1.3	0.2	1.2
Migraine (self-reported)	0.3	0.3	0.6	0.2	0.8
Heart disease (mother)	0.3	0.3	0.7	0.1	-0.8
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.3	0.4	0.5	-0.6	-0.7
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.6	-0.7	0.2
Medication: Atorvastatin	0.3	0.3	0.5	0.3	0.7
Average weekly beer plus cider intake	0.3	0.4	0.4	0.6	-0.7
Irritability	0.3	0.4	0.9	-0.1	-0.9
Basal cell carcinoma (self-reported)	0.3	0.3	0.6	0.3	-0.8
Alcohol drinker status: Previous	0.3	0.4	0.8	-0.1	-0.9
Schizophrenia vs Biploar Disorder	0.2	0.2	0.3	-0.3	-0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.5	0.7	-0.9	-0.5
Breast Cancer	0.2	0.5	0.9	0.2	1.0
Neuroticism (2016)	0.2	0.3	0.4	0.6	-0.4
Triglycerides	0.2	0.3	0.5	0.4	0.7
Hypothyroidism (self reported)	0.2	0.5	0.8	0.9	0.4
Neuroticism	0.2	0.6	1.0	1.0	-0.3
Chronotype (morning person)	0.2	0.5	0.9	0.9	-0.5
Relative age of first facial hair	0.2	0.3	0.6	0.8	0.3
Medication: Co-codamol	0.2	0.3	0.5	0.1	-0.7
Multivitamins +/- minerals	0.2	0.3	0.6	-0.8	0.1
Chronic bronchitis/emphysema (father)	0.2	0.3	0.5	0.7	-0.2
Trunk fat mass	0.2	0.8	0.8	-0.9	0.8
Financial difficulties in last 2 years	0.2	0.3	0.5	-0.7	-0.4
Arm fat percentage (right)	0.2	0.7	1.1	1.1	0.5
Qualifications: O levels/GCSEs or equivalent	0.2	0.4	0.7	0.4	0.8
Glaucoma (self-reported)	0.2	0.2	0.4	-0.1	0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	0.7	0.3	0.9
Chronic bronchitis/emphysema (mother)	0.2	0.3	0.4	-0.3	0.7
Age at first live birth	0.2	0.4	0.5	-0.7	0.6
Eye problems/disorders: None of the above	0.2	0.2	0.3	-0.3	-0.5
Angina (self-reported)	0.2	0.2	0.3	-0.4	-0.6
Whole body fat mass	0.2	0.6	1.0	-0.6	1.0
Alcohol intake frequency.	0.2	0.5	0.7	0.5	-0.8
Overall health rating	0.2	0.5	1.0	0.3	-1.0
Illness, injury, bereavement, stress in last 2 years	0.2	0.3	0.5	0.0	-0.7
Knee pain experienced in last month	0.2	0.3	0.4	-0.5	-0.6
Hypertension (Self-reported)	0.2	0.5	0.7	0.8	-0.6
Arm fat percentage (left)	0.2	0.9	1.8	1.3	0.1
Long-standing illness, disability or infirmity	0.2	0.3	0.5	0.4	-0.7
Mineral and other dietary supplements	0.2	0.3	0.4	0.6	0.4
Medication: Gliclazide	0.2	0.2	0.4	-0.7	-0.2
Arm fat mass (left)	0.2	0.7	1.2	0.4	1.1
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.3	-0.6	0.3
Leg fat percentage (left)	0.2	0.8	1.3	1.1	-0.5
Ever had prostate specific antigen (PSA) test	0.2	0.2	0.5	-0.7	-0.1
Vascular/heart problems diagnosed by doctor	0.2	0.4	0.8	-0.9	0.2
Bipolar Disorder or Schizophrenia	0.1	0.3	0.5	-0.7	-0.2
Worry (Nagel 2018)	0.1	0.3	0.3	0.5	-0.5
Crohns Disease (2017)	0.1	0.1	0.1	0.3	-0.4
Ulcerative Colitis (UC)	0.1	0.3	0.6	-0.7	0.1
Coronary Artery Disease (CAD)	0.1	0.1	0.1	-0.4	0.3
Crohns Disease (2012)	0.1	0.2	0.3	-0.5	0.3
Blood Eosinophil Count	0.1	1.1	2.2	-1.5	-0.2
Heel T-Score	0.1	1.0	1.4	1.2	0.8
Systolic Blood Pressure	0.1	0.6	1.3	-1.1	0.1
Allergy or Eczema	0.1	0.2	0.2	0.5	-0.5
Respiratory disease	0.1	0.3	0.5	-0.2	0.7
Hair Pigment	0.1	1.9	1.9	-1.4	1.4
Hand grip strength (left)	0.1	0.2	0.4	0.1	0.6
Ever had hysterectomy (womb removed)	0.1	0.1	0.1	-0.4	0.2
Angina	0.1	0.1	0.2	-0.2	-0.4
Vitamin and mineral supplements	0.1	0.2	0.4	0.6	0.1
Diabetes (mother)	0.1	0.1	0.1	-0.4	0.3
Stomach or abdominal pain in last month	0.1	0.1	0.1	-0.3	-0.3
Waist circumference	0.1	0.3	0.3	0.6	0.5
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.3	0.4	-0.5
Allergy	0.1	0.1	0.2	0.5	0.2
Hayfever/allergic rhinitis (self-reported)	0.1	0.1	0.2	-0.4	0.3
Neuroticism score	0.1	0.2	0.4	0.6	0.1
Worrier / anxious feelings	0.1	0.2	0.2	0.4	-0.4
Noisy workplace	0.1	0.1	0.2	-0.5	-0.3
Qualifications: A levels/AS levels or equivalent	0.1	0.2	0.2	-0.3	0.5
Arm fat mass (right)	0.1	0.5	0.8	0.4	0.9
Exposure to tobacco smoke at home	0.1	0.1	0.2	-0.5	0.1
Pulse wave reflection index	0.1	0.1	0.2	0.4	-0.3
Medication: Amlodipine	0.1	0.2	0.4	-0.6	-0.1
Medication: Ventolin 100micrograms inhaler	0.1	0.1	0.1	0.3	0.3
Forced vital capacity (FVC), Best measure	0.1	0.4	0.8	-0.1	-0.9
Leg fat percentage (right)	0.1	0.3	0.5	0.7	-0.2
Exposure to tobacco smoke outside home	0.1	0.1	0.3	0.5	-0.0
Wheeze or whistling in the chest in last year	0.1	0.1	0.2	0.4	-0.1
Pulse wave peak to peak time	0.1	0.1	0.2	0.4	-0.3
Medication: Blood pressure	0.1	0.2	0.2	-0.5	0.3
Leg fat mass (right)	0.1	0.3	0.6	0.2	0.8
Leg pain on walking	0.1	0.1	0.1	0.3	0.4
Average weekly champagne plus white wine intake	0.1	0.2	0.3	-0.3	0.6
Miserableness	0.1	0.3	0.5	-0.7	-0.2
Mother’s age at death	0.1	0.2	0.4	0.6	0.1
Leg fat mass (left)	0.1	0.4	0.4	0.6	0.6
Irritable Bowel Disease (IBD)	0.0	0.0	0.1	-0.1	-0.3
Mean Putamen Volume	0.0	0.0	0.0	0.2	0.1
LDL Cholesterol	0.0	0.1	0.1	-0.4	-0.0
Blood White Count	0.0	0.2	0.3	-0.6	0.0
Waist Hip Ratio (WHR)	0.0	0.2	0.3	-0.6	-0.2
Cardiovascular Disease	0.0	0.0	0.1	0.3	0.1
Tanning	0.0	0.4	0.7	0.2	-0.9
Sensitivity / hurt feelings	0.0	0.0	0.0	-0.0	0.1
Hearing difficulty/problems: Yes	0.0	0.0	0.0	0.2	0.2
Trunk fat percentage	0.0	0.0	0.0	-0.1	0.0
High blood pressure	0.0	0.1	0.2	0.4	0.0
Hayfever, allergic rhinitis or eczema	0.0	0.0	0.0	0.1	-0.1
Had other major operations	0.0	0.0	0.0	0.2	0.2
Hip circumference	0.0	0.1	0.1	0.2	0.3
Happiness	0.0	0.0	0.0	-0.1	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.0	0.0	0.0	0.2	0.2
Blood clot in the leg (DVT)	0.0	0.0	0.0	-0.2	0.0
Medication for cholesterol, blood pressure or diabetes	0.0	0.1	0.1	-0.1	-0.3
Body fat percentage	0.0	0.1	0.1	0.4	-0.0
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.0	0.0	0.1	0.2	-0.2
Friendships satisfaction	0.0	0.0	0.0	-0.0	0.1
Commuting to job workplace: Walk	0.0	0.0	0.0	0.1	0.2
Guilty feelings	0.0	0.0	0.0	0.2	-0.2
High cholesterol (Self-reported)	0.0	0.1	0.1	0.3	-0.3
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	-0.3	-0.1
Heart disease (siblings)	0.0	0.0	0.1	-0.0	-0.3

Hub : Genes

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Trait associations