Hub : Genes

FANCI

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Testis 0.188 0.082 0.0040 0.038 NA 0.085 NA 0.055 0.0087 NA 0.00013 NA 0.0018
2 TCGA Bladder Urothelial Carcinoma 0.076 0.042 0.0035 0.000 0.022 0.004 NA 0.000 0.3400 0.0052 0.13000 NA 0.3300

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2
Bipolar Disorder (2018) 0.3 0.6 1.0 0.2 1.0
Bipolar Disorder or Schizophrenia 0.1 0.3 0.5 -0.7 -0.2
Depressed Affect (Nagel 2018) 0.3 0.6 0.6 0.8 -0.7
Depression (Nagel 2018) 0.7 1.0 1.3 1.1 -0.9
Intelligence (Savage-Jansen 2018) 0.3 0.9 1.6 -1.3 0.5
Neuroticism (Nagel 2018) 0.8 2.0 2.6 1.6 -1.2
Schizophrenia (2018) 0.7 1.4 1.6 -1.3 -1.1
Schizophrenia vs Biploar Disorder 0.2 0.2 0.3 -0.3 -0.6
Worry (Nagel 2018) 0.1 0.3 0.3 0.5 -0.5
Alzheimer’s Disease (in mother) 1.2 1.4 2.4 -0.6 1.6
Alzheimer’s Disease (in father) 1.3 1.4 2.0 -0.9 1.4
Alzheimer’s Disease (including proxy) 2.0 2.9 4.5 -1.2 2.1
Crohns Disease (2017) 0.1 0.1 0.1 0.3 -0.4
Irritable Bowel Disease (IBD) 0.0 0.0 0.1 -0.1 -0.3
Ulcerative Colitis (UC) 0.1 0.3 0.6 -0.7 0.1
Major Depression (MDD) 1.2 1.4 2.8 0.1 -1.7
Reaction Time 0.9 1.7 2.7 -0.9 1.6
Verbal and Numeric Reasoning (VNR) 0.2 0.5 0.7 -0.9 -0.5
Breast Cancer 0.2 0.5 0.9 0.2 1.0
Ovarian Cancer 2.9 3.9 7.2 0.8 -2.7
Prostate Cancer 0.4 0.5 0.9 0.9 0.4
Age at First Birth 0.4 0.6 1.2 -1.1 0.2
Bipolar Disorder (2011) 0.4 0.4 0.9 0.9 0.0
Body Mass Index (BMI) (2010) 0.8 1.1 2.1 1.5 -0.2
Coronary Artery Disease (CAD) 0.1 0.1 0.1 -0.4 0.3
Crohns Disease (2012) 0.1 0.2 0.3 -0.5 0.3
Mean Putamen Volume 0.0 0.0 0.0 0.2 0.1
Fasting Glucose 0.9 1.1 1.3 0.9 -1.2
HbA1C 0.4 0.5 0.9 0.1 -1.0
HDL Cholesterol 0.4 0.6 1.2 1.1 -0.1
LDL Cholesterol 0.0 0.1 0.1 -0.4 -0.0
Lupus 0.7 1.1 2.1 -0.3 -1.5
Neuroticism (2016) 0.2 0.3 0.4 0.6 -0.4
Primary Biliary Cirrhosis 0.5 0.8 0.8 0.9 -0.9
Rheumatoid Arthritis 1.2 1.7 3.1 0.5 -1.8
Schizophrenia (2014) 0.3 0.7 1.3 -1.1 -0.2
Triglycerides 0.2 0.3 0.5 0.4 0.7
Type 2 Diabetes (T2D) (2012) 0.4 0.4 0.8 0.9 0.2
Ulcerative Colitis 0.3 0.4 0.6 -0.4 -0.8
Blood Eosinophil Count 0.1 1.1 2.2 -1.5 -0.2
Blood Platelet Count 1.1 12.3 16.6 2.8 -4.1
Blood Red Count 0.4 4.3 8.4 -0.4 2.9
Blood White Count 0.0 0.2 0.3 -0.6 0.0
Heel T-Score 0.1 1.0 1.4 1.2 0.8
BMI 0.3 1.9 2.1 1.4 1.3
Height 4.5 87.4 163.8 -12.8 3.3
Waist Hip Ratio (WHR) 0.0 0.2 0.3 -0.6 -0.2
Systolic Blood Pressure 0.1 0.6 1.3 -1.1 0.1
Smoking Status 3.1 7.3 9.8 -3.1 2.2
Allergy or Eczema 0.1 0.2 0.2 0.5 -0.5
Cardiovascular Disease 0.0 0.0 0.1 0.3 0.1
Hypothyroidism (self reported) 0.2 0.5 0.8 0.9 0.4
Respiratory disease 0.1 0.3 0.5 -0.2 0.7
Type 2 Diabetes (T2D) (2018) 0.6 1.1 1.2 -1.1 1.0
Lung FEV1/FVC ratio 0.4 2.0 3.5 1.9 0.7
Lung FVC 0.9 4.6 5.6 1.9 -2.4
Neuroticism 0.2 0.6 1.0 1.0 -0.3
Chronotype (morning person) 0.2 0.5 0.9 0.9 -0.5
Hair Pigment 0.1 1.9 1.9 -1.4 1.4
Tanning 0.0 0.4 0.7 0.2 -0.9
Hand grip strength (left) 0.1 0.2 0.4 0.1 0.6
Number of treatments/medications taken 0.3 0.5 1.0 1.0 -0.3
Average weekly spirits intake 0.4 0.4 0.7 -0.5 0.8
Sensitivity / hurt feelings 0.0 0.0 0.0 -0.0 0.1
Frequency of depressed mood in last 2 weeks 2.0 2.8 5.5 2.4 -0.3
Hearing difficulty/problems: Yes 0.0 0.0 0.0 0.2 0.2
Relative age of first facial hair 0.2 0.3 0.6 0.8 0.3
Other serious medical condition/disability diagnosed by doctor 0.3 0.4 0.7 0.3 0.9
Ever used hormone-replacement therapy (HRT) 4.7 5.9 10.7 1.1 -3.3
Ever had hysterectomy (womb removed) 0.1 0.1 0.1 -0.4 0.2
Systolic blood pressure, automated reading 0.3 0.9 1.6 -1.3 0.5
Eye problems/disorders: Diabetes related eye disease 4.1 4.5 6.4 -1.6 2.5
Angina 0.1 0.1 0.2 -0.2 -0.4
Medication for hormone replacement therapy 0.7 0.8 1.6 1.2 -0.3
Vitamin and mineral supplements 0.1 0.2 0.4 0.6 0.1
Supplements: Zinc 2.7 2.9 5.6 -2.4 0.5
Medication: Co-codamol 0.2 0.3 0.5 0.1 -0.7
Medication: Metformin 0.5 0.7 0.8 -0.9 0.7
Diabetes (father) 0.5 0.7 0.9 1.0 -0.6
Diabetes (mother) 0.1 0.1 0.1 -0.4 0.3
Severe depression (siblings) 0.3 0.4 0.7 -0.8 0.0
Pack years adult smoking proportion 3.1 4.8 7.3 2.7 -1.5
Impedance of leg (right) 1.0 4.7 8.3 -2.9 -1.1
Leg fat-free mass (left) 0.8 4.0 5.3 -1.6 2.3
Trunk fat percentage 0.0 0.0 0.0 -0.1 0.0
Hand grip strength (right) 0.3 0.7 1.3 1.1 -0.4
Townsend deprivation index at recruitment 0.3 0.4 0.7 0.8 -0.3
Current tobacco smoking 0.3 0.4 0.6 -0.5 0.8
Average weekly fortified wine intake 0.3 0.4 0.7 -0.8 -0.2
Maternal smoking around birth 0.9 1.3 2.4 -0.4 -1.6
Fed-up feelings 0.6 1.1 1.8 1.4 -0.6
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.5 0.6 0.8 0.7
Relative age voice broke 1.7 2.6 4.2 -1.0 2.0
Taking other prescription medications 0.3 0.4 0.7 0.4 -0.8
Age when periods started (menarche) 0.4 1.0 2.0 -0.0 -1.4
Bilateral oophorectomy (both ovaries removed) 4.3 5.0 6.9 -2.6 1.8
Heel bone mineral density (BMD) T-score, automated (left) 0.8 1.9 3.6 0.5 1.9
Tinnitus: Yes, but not now, but have in the past 0.3 0.3 0.6 0.8 0.3
Qualifications: CSEs or equivalent 4.0 5.3 7.2 2.7 -1.9
Serious illness, injury or assault to yourself 3.6 4.4 6.4 -1.6 2.5
High blood pressure 0.0 0.1 0.2 0.4 0.0
Hayfever, allergic rhinitis or eczema 0.0 0.0 0.0 0.1 -0.1
Multivitamins +/- minerals 0.2 0.3 0.6 -0.8 0.1
Stomach or abdominal pain in last month 0.1 0.1 0.1 -0.3 -0.3
Supplements: Glucosamine 0.3 0.4 0.7 0.8 -0.5
Diverticular disease/diverticulitis (self-reported) 1.0 1.2 2.3 -1.5 -0.3
Medication: Atenolol 0.4 0.5 0.9 0.0 -1.0
Medication: Levothyroxine sodium 0.5 0.9 1.6 0.5 1.2
Sitting height 3.4 24.1 45.8 -6.8 1.5
Chronic bronchitis/emphysema (father) 0.2 0.3 0.5 0.7 -0.2
High blood pressure (mother) 1.9 2.6 3.5 1.9 -1.3
Body mass index (BMI) 0.8 3.3 6.3 2.5 0.6
Impedance of leg (left) 0.9 4.2 6.0 -2.5 -1.5
Leg predicted mass (left) 0.7 3.9 5.3 -1.6 2.3
Trunk fat mass 0.2 0.8 0.8 -0.9 0.8
Waist circumference 0.1 0.3 0.3 0.6 0.5
Number of incorrect matches in round 0.4 0.6 0.9 0.6 -0.9
Past tobacco smoking 3.5 6.5 8.0 2.8 -2.2
Alcohol usually taken with meals 0.3 0.5 0.6 -0.8 0.6
Nervous feelings 0.7 1.4 2.3 1.5 -0.7
Frequency of tenseness / restlessness in last 2 weeks 0.1 0.2 0.3 0.4 -0.5
Hearing difficulty/problems with background noise 1.5 2.3 3.2 -1.8 1.2
Hair/balding pattern: Pattern 2 0.7 0.9 1.8 -1.4 -0.1
Had menopause 3.0 3.8 5.6 1.4 -2.4
Had other major operations 0.0 0.0 0.0 0.2 0.2
Forced vital capacity (FVC) 0.3 1.1 2.2 -0.2 -1.5
Heel bone mineral density (BMD) T-score, automated (right) 0.4 1.0 1.6 1.3 0.6
Ever unenthusiastic/disinterested for a whole week 0.9 1.0 1.9 -1.4 0.4
Qualifications: None of the above 0.4 0.8 1.2 -1.1 0.6
Financial difficulties in last 2 years 0.2 0.3 0.5 -0.7 -0.4
Mouth/teeth dental problems 1.6 2.5 3.6 1.2 -1.9
Heart attack 0.6 0.8 1.2 1.1 -0.7
Allergy 0.1 0.1 0.2 0.5 0.2
Pain all over the body in last month 0.4 0.4 0.5 0.7 -0.5
Diabetes (self-reported) 0.5 0.8 1.0 -0.8 1.0
Hayfever/allergic rhinitis (self-reported) 0.1 0.1 0.2 -0.4 0.3
Medication: Ramipril 0.6 0.7 1.5 0.1 -1.2
Medication: Simvastatin 2.2 3.2 6.2 0.5 -2.5
Fluid intelligence score 0.3 0.6 1.1 -0.3 -1.1
Illnesses of siblings 0.5 0.7 1.1 -0.5 1.0
Neuroticism score 0.1 0.2 0.4 0.6 0.1
Weight 0.4 2.0 2.3 -1.3 1.5
Impedance of arm (right) 0.8 3.5 6.5 -2.5 -0.7
Arm fat percentage (right) 0.2 0.7 1.1 1.1 0.5
Trunk fat-free mass 1.9 11.2 12.8 -3.6 3.1
Hip circumference 0.0 0.1 0.1 0.2 0.3
Time employed in main current job 0.4 0.5 0.7 -0.5 -0.9
Alcohol intake versus 10 years previously 1.8 2.7 4.0 -2.0 1.2
Father’s age at death 0.8 1.1 1.2 -1.0 1.1
Worrier / anxious feelings 0.1 0.2 0.2 0.4 -0.4
Frequency of tiredness / lethargy in last 2 weeks 0.4 0.7 1.3 1.2 -0.2
Falls in the last year 0.3 0.4 0.8 -0.0 0.9
Hair/balding pattern: Pattern 3 1.8 2.7 5.1 2.3 -0.6
Number of live births 1.8 2.6 3.3 1.8 -1.3
Forced expiratory volume in 1-second (FEV1) 0.7 2.4 3.6 1.1 -1.9
Pulse rate 1.4 2.3 4.2 -0.6 2.1
Happiness 0.0 0.0 0.0 -0.1 -0.0
Noisy workplace 0.1 0.1 0.2 -0.5 -0.3
Qualifications: A levels/AS levels or equivalent 0.1 0.2 0.2 -0.3 0.5
Serious illness, injury or assault of a close relative in last 2 years 0.0 0.0 0.0 0.2 0.2
Mouth/teeth dental problems: Dentures 1.0 1.6 1.9 -1.4 1.2
Asthma 0.6 1.2 1.5 -1.2 1.0
Medication: Ibuprofen (e.g. Nurofen) 2.4 3.1 6.1 2.5 -0.2
Medication: Cholesterol lowering 1.2 1.8 2.4 1.1 -1.6
Depression (self-reported) 0.5 0.6 0.7 0.8 0.7
Medication: Lansoprazole 3.8 4.4 5.9 1.7 -2.4
Prospective memory result 1.2 1.4 2.8 0.3 -1.7
Lung cancer (father) 0.4 0.4 0.6 0.8 0.5
Illnesses of mother 0.3 0.4 0.6 -0.3 0.8
Forced expiratory volume in 1-second (FEV1), Best measure 0.4 1.3 1.4 1.2 -1.1
Pulse wave Arterial Stiffness index 0.7 0.8 1.4 -1.2 0.5
Impedance of arm (left) 0.8 3.6 5.4 -2.3 -1.3
Arm fat mass (right) 0.1 0.5 0.8 0.4 0.9
Trunk predicted mass 2.0 11.4 12.8 -3.6 3.2
Standing height 4.0 39.3 72.1 -8.5 2.5
Length of working week for main job 1.5 1.6 1.8 1.2 1.3
Exposure to tobacco smoke at home 0.1 0.1 0.2 -0.5 0.1
Breastfed as a baby 3.5 4.4 5.9 -2.4 1.7
Tense / ‘highly strung’ 0.9 1.5 1.8 1.1 -1.3
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 0.9 -1.0 0.9
Hair/balding pattern: Pattern 4 0.3 0.6 1.3 -0.1 1.1
Birth weight of first child 4.4 7.9 8.1 -2.8 2.8
Peak expiratory flow (PEF) 0.4 1.0 1.6 0.6 -1.3
Pulse wave reflection index 0.1 0.1 0.2 0.4 -0.3
Ever highly irritable/argumentative for 2 days 0.4 0.5 0.8 0.9 0.5
Loud music exposure frequency 0.5 0.5 0.7 0.5 -0.9
Qualifications: O levels/GCSEs or equivalent 0.2 0.4 0.7 0.4 0.8
Mouth/teeth dental problems: Bleeding gums 0.7 0.9 1.7 1.3 0.2
Blood clot in the leg (DVT) 0.0 0.0 0.0 -0.2 0.0
Medication: Paracetamol 1.0 1.6 1.6 1.3 -1.3
Headache pain in last month 4.2 7.2 9.0 3.0 -2.3
Medication for cholesterol, blood pressure or diabetes 0.0 0.1 0.1 -0.1 -0.3
Glaucoma (self-reported) 0.2 0.2 0.4 -0.1 0.6
Gout (self-reported) 0.4 0.6 1.0 0.3 -1.0
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 0.7 0.3 0.9
Medication: Amlodipine 0.1 0.2 0.4 -0.6 -0.1
Medication: Ventolin 100micrograms inhaler 0.1 0.1 0.1 0.3 0.3
Birth weight 0.3 0.7 1.3 0.2 1.2
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.4 -0.3 0.7
High blood pressure (siblings) 0.8 1.2 2.3 0.2 -1.5
Forced vital capacity (FVC), Best measure 0.1 0.4 0.8 -0.1 -0.9
Body fat percentage 0.0 0.1 0.1 0.4 -0.0
Leg fat percentage (right) 0.1 0.3 0.5 0.7 -0.2
Arm fat-free mass (right) 0.8 4.2 4.8 -1.9 2.2
Exposure to tobacco smoke outside home 0.1 0.1 0.3 0.5 -0.0
Comparative body size at age 10 3.9 10.7 21.1 4.6 -0.5
Number of full brothers 0.4 0.5 0.6 0.6 -0.8
Worry too long after embarrassment 1.4 2.4 4.8 2.2 -0.1
Seen a psychiatrist for nerves, anxiety, tension or depression 1.8 2.4 4.5 2.1 0.5
Wheeze or whistling in the chest in last year 0.1 0.1 0.2 0.4 -0.1
Number of children fathered 2.1 2.4 2.4 -1.5 1.5
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.0 0.4 -1.0
Age at first live birth 0.2 0.4 0.5 -0.7 0.6
Pulse wave peak to peak time 0.1 0.1 0.2 0.4 -0.3
Health satisfaction 2.7 3.5 4.3 2.1 -1.6
Shortness of breath walking on level ground 0.9 1.0 1.3 0.9 -1.1
Qualifications: College or University degree 0.5 1.7 2.1 -1.1 1.4
Eye problems/disorders: None of the above 0.2 0.2 0.3 -0.3 -0.5
Mouth/teeth dental problems: Loose teeth 0.9 1.1 2.2 1.5 -0.0
Emphysema/chronic bronchitis 5.0 5.7 6.1 -2.3 2.5
Medication for pain relief, constipation, heartburn 1.7 2.9 3.0 -1.7 1.7
Neck or shoulder pain in last month 0.7 1.0 1.9 1.4 -0.4
Medication: Blood pressure 0.1 0.2 0.2 -0.5 0.3
Angina (self-reported) 0.2 0.2 0.3 -0.4 -0.6
Migraine (self-reported) 0.3 0.3 0.6 0.2 0.8
Medication: Ibuprofen 2.6 3.1 6.2 2.5 -0.4
Medication: Allopurinol 0.8 1.1 1.4 0.9 -1.2
Medication: Omeprazole 1.7 2.0 3.3 0.9 -1.8
Medication: Seretide 50 evohaler 1.1 1.2 2.0 0.7 -1.4
Mean time to correctly identify matches 2.0 3.8 5.0 -1.6 2.2
Heart disease (mother) 0.3 0.3 0.7 0.1 -0.8
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.9 1.1 1.9 1.4 -0.5
Whole body fat mass 0.2 0.6 1.0 -0.6 1.0
Leg fat mass (right) 0.1 0.3 0.6 0.2 0.8
Arm predicted mass (right) 0.8 4.3 5.1 -1.9 2.3
Pulse rate, automated reading 0.6 1.9 3.4 -0.6 1.8
Alcohol intake frequency. 0.2 0.5 0.7 0.5 -0.8
Comparative height size at age 10 3.2 17.4 31.5 -5.6 1.8
Number of full sisters 2.9 3.5 6.7 -2.6 0.5
Suffer from ‘nerves’ 1.2 1.8 3.5 1.9 -0.3
Overall health rating 0.2 0.5 1.0 0.3 -1.0
Chest pain or discomfort 0.9 1.3 2.5 -1.6 0.2
Had major operations 1.6 1.8 3.2 0.7 -1.8
Age at last live birth 0.5 0.7 1.2 -1.1 0.4
Family relationship satisfaction 0.8 1.0 1.5 1.2 0.7
Leg pain on walking 0.1 0.1 0.1 0.3 0.4
Qualifications: NVQ or HND or HNC or equivalent 2.0 2.5 3.2 1.8 -1.3
Commuting to job workplace: Car/motor vehicle 0.8 0.9 1.8 -1.3 0.0
Illness, injury, bereavement, stress in last 2 years 0.2 0.3 0.5 0.0 -0.7
Medication: Aspirin 0.7 1.0 1.3 -0.8 -1.2
Supplements: Vitamin C 1.6 1.9 3.5 -1.9 0.5
Knee pain experienced in last month 0.2 0.3 0.4 -0.5 -0.6
Hypertension (Self-reported) 0.2 0.5 0.7 0.8 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.0 0.0 0.1 0.2 -0.2
Illnesses of father: Heart disease 0.6 0.8 1.3 1.1 0.6
Illnesses of siblings: Diabetes 0.7 0.8 1.4 0.4 -1.2
Smoking status: Previous 2.3 3.4 3.5 -1.9 1.8
Forced expiratory volume in 1-second (FEV1), predicted 1.1 2.4 3.6 -1.1 1.9
Whole body fat-free mass 1.3 7.7 8.1 -2.7 2.8
Leg fat-free mass (right) 0.5 2.9 3.8 -1.4 2.0
Arm fat percentage (left) 0.2 0.9 1.8 1.3 0.1
Average weekly red wine intake 1.0 1.5 1.6 -1.3 1.2
Handedness (chirality/laterality): Left-handed 2.4 2.8 4.8 -0.9 2.2
Mood swings 0.4 0.8 1.4 1.2 0.4
Loneliness, isolation 1.4 1.9 3.8 1.9 0.0
Long-standing illness, disability or infirmity 0.2 0.3 0.5 0.4 -0.7
Ever had bowel cancer screening 6.1 7.1 12.5 -3.5 1.4
Diabetes diagnosed by doctor 0.5 0.8 0.9 -0.8 1.0
Ever had stillbirth, spontaneous miscarriage or termination 0.6 0.6 1.0 -1.0 0.5
Friendships satisfaction 0.0 0.0 0.0 -0.0 0.1
Qualifications: nursing, teaching 1.3 1.9 3.4 1.8 -0.7
Commuting to job workplace: Walk 0.0 0.0 0.0 0.1 0.2
Eye problems/disorders: Cataract 1.8 2.1 3.7 1.9 -0.8
Mouth/teeth dental problems: Mouth ulcers 0.8 1.3 1.8 -0.9 1.3
Medication for cholesterol 2.0 3.1 3.8 -1.5 2.0
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.3 0.4 0.5 -0.6 -0.7
Back pain experienced in last month 0.5 0.8 0.8 0.9 -0.9
Mineral and other dietary supplements 0.2 0.3 0.4 0.6 0.4
Breast cancer (self-reported) 0.5 0.6 0.8 0.9 -0.6
Asthma (self-reported) 0.5 1.1 1.1 -1.0 1.0
Osteoporosis (self-reported) 0.6 0.7 1.0 -1.0 -0.7
Osteoarthritis (self-reported) 0.5 0.6 1.2 0.1 -1.1
Medication: Aspirin 0.8 1.1 1.3 -0.9 -1.1
Medication: Gliclazide 0.2 0.2 0.4 -0.7 -0.2
Illnesses of father: None of the above (group 1) 1.5 1.8 3.6 -1.9 0.2
Smoking status: Current 0.6 1.0 1.1 -1.0 1.0
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.8 1.7 2.2 1.5 -1.1
Whole body water mass 1.3 7.5 8.1 -2.6 2.9
Leg predicted mass (right) 0.6 3.1 4.3 -1.4 2.1
Arm fat mass (left) 0.2 0.7 1.2 0.4 1.1
Number of self-reported non-cancer illnesses 0.4 0.6 1.0 -1.0 0.6
Average weekly champagne plus white wine intake 0.1 0.2 0.3 -0.3 0.6
Miserableness 0.1 0.3 0.5 -0.7 -0.2
Guilty feelings 0.0 0.0 0.0 0.2 -0.2
Wears glasses or contact lenses 1.3 1.5 2.7 -1.7 0.5
Ever taken oral contraceptive pill 1.0 1.1 1.6 0.7 -1.3
Hearing aid user 0.4 0.4 0.7 0.3 0.9
Mother’s age at death 0.1 0.2 0.4 0.6 0.1
Financial situation satisfaction 1.4 1.8 2.9 1.7 -0.8
Tinnitus: Yes, now most or all of the time 0.3 0.3 0.6 -0.7 0.2
Commuting to job workplace: Public transport 0.5 0.6 1.2 1.1 0.2
Eye problems/disorders: Glaucoma 0.5 0.7 1.0 -1.0 0.6
Medication: Blood pressure 1.2 2.3 4.1 0.7 -2.0
Pain type(s) experienced in last month: Hip pain 1.4 1.8 2.8 -1.7 0.9
Supplements: Fish oil (including cod liver oil) 0.2 0.2 0.3 -0.6 0.3
High cholesterol (Self-reported) 0.0 0.1 0.1 0.3 -0.3
Medication: Bendroflumethiazide 0.6 1.0 1.3 0.8 -1.1
Medication: Paracetamol 1.1 1.8 3.1 1.8 -0.7
Medication: Lisinopril 1.2 1.5 3.0 0.3 -1.7
Medication: Atorvastatin 0.3 0.3 0.5 0.3 0.7
Illnesses of father: High blood pressure 2.1 2.6 2.9 1.7 -1.5
Alcohol drinker status: Never 0.8 0.9 1.8 -1.3 0.4
Ever smoked 3.8 6.6 7.1 -2.7 2.5
Basal metabolic rate 1.1 6.1 6.3 -2.4 2.5
Leg fat percentage (left) 0.2 0.8 1.3 1.1 -0.5
Arm fat-free mass (left) 1.1 5.6 6.6 -2.1 2.6
Number of operations (self-reported) 1.1 1.6 3.2 -1.8 -0.0
Average weekly beer plus cider intake 0.3 0.4 0.4 0.6 -0.7
Irritability 0.3 0.4 0.9 -0.1 -0.9
Risk taking 0.6 0.9 1.5 1.2 -0.6
Ever had prostate specific antigen (PSA) test 0.2 0.2 0.5 -0.7 -0.1
Fractured/broken bones in last 5 years 0.6 0.7 0.9 0.7 -0.9
Age started oral contraceptive pill 2.4 2.9 5.8 -2.4 -0.3
Diastolic blood pressure, automated reading 0.5 1.6 2.6 -0.8 1.6
Ever depressed for a whole week 4.3 5.3 5.4 -2.3 2.3
Unable to work because of sickness or disability 0.8 1.0 1.2 0.9 1.1
Commuting to job workplace: Cycle 0.7 0.9 1.8 -0.0 1.3
Myopia 1.0 1.5 3.0 -1.7 -0.0
Vascular/heart problems diagnosed by doctor 0.2 0.4 0.8 -0.9 0.2
Cholesterol lowering medication 0.4 0.6 0.8 -0.9 -0.6
Medication: Omeprazole (e.g. Zanprol) 2.8 3.4 5.4 1.2 -2.3
Pain experienced in last month 0.6 1.0 1.6 -1.2 0.6
Supplements: Calcium 1.1 1.2 2.5 -1.6 -0.0
Basal cell carcinoma (self-reported) 0.3 0.3 0.6 0.3 -0.8
Heart attack/myocardial infarction (self-reported) 0.5 0.6 1.0 1.0 -0.5
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.1 -0.3 -0.1
Heart disease (siblings) 0.0 0.0 0.1 -0.0 -0.3
Alcohol drinker status: Previous 0.3 0.4 0.8 -0.1 -0.9
Pack years of smoking 3.6 5.3 7.5 2.7 -1.8
Impedance of whole body 0.9 4.7 6.5 -2.5 -1.7
Leg fat mass (left) 0.1 0.4 0.4 0.6 0.6
Arm predicted mass (left) 1.2 5.9 6.8 -2.2 2.6