TWAS hub - ACSM3

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	TCGA	Prostate Adenocarcinoma	0.0594	0.0326	1.3e-05	0.057	0.05	0.048	NA	0.053	1.3e-06	5.9e-06	9.4e-06	NA	2.8e-06
2	TCGA	Thyroid Carcinoma	0.0590	0.0420	4.7e-04	0.035	0.03	0.025	NA	0.019	2.1e-04	5.9e-04	1.6e-03	NA	5.7e-03

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2
Sitting height	6.5	45.8	45.8	6.8	6.8
Arm predicted mass (left)	5.3	27.0	27.6	5.1	5.2
Comparative height size at age 10	5.2	28.6	28.7	5.3	5.4
Arm fat-free mass (left)	5.2	26.6	27.1	5.1	5.2
Trunk fat-free mass	5.1	29.3	30.4	5.3	5.5
Trunk predicted mass	5.1	29.1	30.1	5.3	5.5
Arm fat-free mass (right)	4.6	23.5	23.9	4.8	4.9
Arm predicted mass (right)	4.6	23.3	23.4	4.8	4.8
Whole body fat-free mass	4.2	24.2	24.8	4.9	5.0
Whole body water mass	4.2	24.0	24.5	4.8	5.0
Maternal smoking around birth	4.0	5.7	6.5	2.2	2.5
Basal metabolic rate	3.7	20.3	20.6	4.5	4.5
Coronary Artery Disease (CAD)	3.6	4.3	4.9	-2.2	-1.9
Standing height	3.4	33.6	34.0	5.8	5.8
Ever smoked	3.3	5.7	5.9	2.4	2.4
Systolic Blood Pressure	3.2	16.1	20.2	-3.5	-4.5
Age when periods started (menarche)	3.2	7.6	8.5	-2.9	-2.6
Forced vital capacity (FVC)	3.2	12.3	14.3	3.8	3.2
Smoking Status	3.1	7.5	7.6	2.7	2.7
Had major operations	3.0	3.5	3.6	1.9	1.9
Past tobacco smoking	2.8	5.2	5.3	-2.2	-2.3
Pain all over the body in last month	2.8	3.0	3.4	1.6	1.8
Forced vital capacity (FVC), Best measure	2.7	10.0	12.2	3.5	2.8
Diabetes diagnosed by doctor	2.7	4.5	4.9	-2.2	-2.0
Fractured/broken bones in last 5 years	2.7	3.5	3.6	-1.9	-1.8
Height	2.6	51.1	51.3	7.1	7.2
Respiratory disease	2.6	5.8	6.0	2.4	2.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.6	3.1	3.3	-1.8	-1.7
Type 2 Diabetes (T2D) (2018)	2.5	4.7	4.9	-2.2	-2.1
Medication for cholesterol, blood pressure or diabetes	2.5	4.1	4.6	1.9	2.1
Leg fat-free mass (right)	2.5	13.3	13.5	3.6	3.7
Leg predicted mass (right)	2.5	13.3	13.5	3.6	3.7
Average weekly champagne plus white wine intake	2.5	3.4	4.3	-2.1	-1.6
Heart disease (siblings)	2.4	2.9	3.1	-1.7	-1.8
Leg fat-free mass (left)	2.3	12.4	12.9	3.5	3.6
High blood pressure	2.3	6.4	8.3	-2.1	-2.9
Medication: Atenolol	2.3	2.9	3.6	-1.9	-1.5
Leg predicted mass (left)	2.3	12.2	12.7	3.4	3.6
Hypertension (Self-reported)	2.3	6.5	8.1	-2.2	-2.8
Cardiovascular Disease	2.2	7.2	8.6	-2.4	-2.9
Other serious medical condition/disability diagnosed by doctor	2.2	2.8	3.8	1.4	1.9
Current tobacco smoking	2.2	3.6	4.3	1.7	2.1
Glaucoma (self-reported)	2.2	2.6	3.3	1.4	1.8
Smoking status: Previous	2.2	3.3	3.6	1.9	1.7
Average weekly red wine intake	2.2	3.3	3.5	1.7	1.9
Smoking status: Current	2.2	3.5	4.0	1.7	2.0
Alzheimer’s Disease (including proxy)	2.1	3.1	3.2	1.7	1.8
Eye problems/disorders: Diabetes related eye disease	2.1	2.3	3.2	-1.8	-1.1
High blood pressure (mother)	2.1	3.0	3.8	-1.4	-2.0
Impedance of arm (left)	2.1	9.7	10.1	-3.0	-3.2
Diastolic blood pressure, automated reading	2.1	6.5	8.2	-2.2	-2.9
Pulse wave reflection index	2.0	2.5	3.1	-1.8	-1.4
Asthma (self-reported)	2.0	4.0	4.7	2.2	1.8
Alzheimer’s Disease (in mother)	1.9	2.2	2.3	1.4	1.5
Crohns Disease (2012)	1.9	3.1	3.1	1.8	1.8
Birth weight of first child	1.9	3.4	3.8	-1.8	-1.9
Medication: Ventolin 100micrograms inhaler	1.9	2.4	3.4	1.8	1.2
Supplements: Vitamin C	1.9	2.2	2.3	1.5	1.5
Medication for cholesterol	1.9	2.9	3.2	1.8	1.6
Medication: Lisinopril	1.8	2.3	2.4	-1.5	-1.5
Vascular/heart problems diagnosed by doctor	1.8	4.8	6.2	1.9	2.5
Mean Putamen Volume	1.7	1.9	2.3	-1.5	-1.2
Forced expiratory volume in 1-second (FEV1)	1.7	5.7	6.8	2.6	2.1
Forced expiratory volume in 1-second (FEV1), predicted	1.7	3.4	4.3	2.1	1.6
Emphysema/chronic bronchitis	1.6	1.8	2.3	1.2	1.5
Hair/balding pattern: Pattern 3	1.5	2.2	2.7	1.3	1.6
Illnesses of mother	1.5	1.9	2.8	1.0	1.7
Exposure to tobacco smoke at home	1.5	1.7	2.1	1.1	1.5
Medication: Blood pressure	1.5	2.6	3.3	-1.4	-1.8
Medication: Gliclazide	1.5	1.7	1.8	-1.4	-1.3
Basal cell carcinoma (self-reported)	1.5	1.7	3.0	1.7	0.7
Schizophrenia vs Biploar Disorder	1.4	1.8	2.2	-1.2	-1.5
Number of incorrect matches in round	1.4	2.3	2.4	-1.4	-1.6
Financial difficulties in last 2 years	1.4	1.9	2.2	1.5	1.3
Diabetes (self-reported)	1.4	2.2	2.4	-1.5	-1.4
Hayfever/allergic rhinitis (self-reported)	1.4	1.8	2.1	-1.2	-1.5
Weight	1.4	6.9	7.0	2.6	2.6
Lung cancer (father)	1.4	1.6	1.8	1.2	1.3
Blood clot in the leg (DVT)	1.4	1.8	2.7	-0.9	-1.6
Medication: Amlodipine	1.4	1.9	2.3	-1.2	-1.5
Medication: Bendroflumethiazide	1.4	2.1	2.2	-1.4	-1.5
Verbal and Numeric Reasoning (VNR)	1.3	3.2	4.7	1.3	2.2
Number of treatments/medications taken	1.3	2.3	2.5	-1.5	-1.6
Diverticular disease/diverticulitis (self-reported)	1.3	1.5	2.3	0.9	1.5
Medication: Simvastatin	1.3	2.0	2.2	-1.5	-1.3
Falls in the last year	1.3	1.7	2.1	1.4	1.2
Forced expiratory volume in 1-second (FEV1), Best measure	1.3	4.2	5.9	2.4	1.6
Breastfed as a baby	1.3	1.6	1.8	-1.2	-1.4
Hearing aid user	1.3	1.5	2.2	0.9	1.5
Medication: Atorvastatin	1.3	1.6	2.0	-1.4	-1.1
Medication: Metformin	1.2	1.7	2.4	-1.6	-1.0
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	1.7	-1.3	-1.0
Impedance of arm (right)	1.2	5.4	5.5	-2.4	-2.3
Birth weight	1.2	2.6	2.7	1.6	1.6
Angina (self-reported)	1.2	1.5	2.2	-1.5	-0.9
Heart disease (mother)	1.2	1.4	1.9	-1.0	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	1.5	-1.1	-1.2
Financial situation satisfaction	1.2	1.5	2.1	1.0	1.4
Risk taking	1.2	1.8	2.8	1.7	0.9
Deep venous thrombosis (DVT) (self-reported)	1.2	1.6	2.4	-0.8	-1.6
HDL Cholesterol	1.1	1.9	2.1	-1.3	-1.4
Chronic bronchitis/emphysema (father)	1.1	1.3	2.1	1.5	0.7
Noisy workplace	1.1	1.4	1.5	1.1	1.2
Asthma	1.1	2.2	2.8	1.7	1.3
Medication: Cholesterol lowering	1.1	1.7	1.9	-1.2	-1.4
Medication: Seretide 50 evohaler	1.1	1.3	1.4	1.1	1.2
Tinnitus: Yes, now most or all of the time	1.1	1.3	1.7	1.3	1.0
Reaction Time	1.0	1.9	2.2	-1.3	-1.5
Supplements: Zinc	1.0	1.1	1.3	-0.9	-1.2
Medication: Co-codamol	1.0	1.1	1.6	1.3	0.8
Gout (self-reported)	1.0	1.4	1.5	1.2	1.1
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	1.5	1.2	0.9
Breast cancer (self-reported)	1.0	1.2	1.3	-1.1	-1.1
Wears glasses or contact lenses	1.0	1.2	1.4	1.2	1.0
Average weekly beer plus cider intake	1.0	1.4	1.5	1.2	1.1
Crohns Disease (2017)	0.9	1.9	2.0	1.3	1.4
Breast Cancer	0.9	2.1	2.6	1.3	1.6
Angina	0.9	1.2	1.8	-1.3	-0.8
Severe depression (siblings)	0.9	1.0	1.6	-0.7	-1.3
High blood pressure (siblings)	0.9	1.3	1.5	-1.0	-1.2
Bipolar Disorder (2011)	0.8	0.8	1.2	0.6	1.1
Waist Hip Ratio (WHR)	0.8	3.8	5.4	1.5	2.3
Lung FVC	0.8	4.3	5.2	2.3	1.9
Diabetes (mother)	0.8	1.1	1.3	-0.9	-1.1
Medication: Lansoprazole	0.8	0.9	1.0	1.0	0.9
Mouth/teeth dental problems: Mouth ulcers	0.8	1.2	1.6	1.2	1.0
Impedance of whole body	0.8	4.2	4.3	-2.0	-2.1
Blood Red Count	0.7	7.2	9.4	2.2	3.1
Heel T-Score	0.7	5.3	6.9	-1.9	-2.6
Medication: Levothyroxine sodium	0.7	1.2	1.5	-1.2	-0.9
Hearing difficulty/problems with background noise	0.7	1.2	1.7	-0.8	-1.3
Illnesses of siblings	0.7	1.1	1.5	0.8	1.2
Alcohol intake versus 10 years previously	0.7	1.0	1.2	0.9	1.1
Ever highly irritable/argumentative for 2 days	0.7	0.9	1.0	1.0	0.9
Number of full brothers	0.7	0.9	1.0	1.0	0.9
Knee pain experienced in last month	0.7	1.1	1.3	-1.0	-1.1
Age started oral contraceptive pill	0.7	0.9	1.2	-0.8	-1.1
Pulse rate	0.6	1.1	1.2	1.1	1.0
Length of working week for main job	0.6	0.6	0.8	0.7	0.9
Loud music exposure frequency	0.6	0.7	0.8	0.9	0.8
Number of children fathered	0.6	0.6	0.8	0.9	0.7
Mean time to correctly identify matches	0.6	1.2	1.4	-1.0	-1.2
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	1.4	0.5	1.2
Illnesses of siblings: Diabetes	0.6	0.7	0.9	-0.8	-0.9
Eye problems/disorders: Cataract	0.6	0.7	0.7	-0.8	-0.9
Medication: Blood pressure	0.6	1.1	1.2	-0.9	-1.1
Pain type(s) experienced in last month: Hip pain	0.6	0.8	1.1	1.0	0.7
Schizophrenia (2018)	0.5	0.9	1.8	-0.3	-1.3
Fasting Glucose	0.5	0.6	0.8	0.6	0.9
HbA1C	0.5	0.6	0.8	0.9	0.6
Neuroticism	0.5	1.2	1.2	-1.1	-1.1
Sensitivity / hurt feelings	0.5	0.9	0.9	-1.0	-1.0
Systolic blood pressure, automated reading	0.5	1.5	2.2	-0.8	-1.5
Townsend deprivation index at recruitment	0.5	0.7	0.8	0.7	0.9
Nervous feelings	0.5	0.9	1.5	-1.2	-0.6
Allergy	0.5	1.2	1.7	-1.3	-0.9
Shortness of breath walking on level ground	0.5	0.6	0.6	0.8	0.8
Number of full sisters	0.5	0.6	0.8	-0.6	-0.9
Arm fat percentage (left)	0.5	2.1	2.3	-1.4	-1.5
Handedness (chirality/laterality): Left-handed	0.5	0.6	0.7	-0.7	-0.8
Number of self-reported non-cancer illnesses	0.5	0.9	1.1	-1.1	-0.8
Eye problems/disorders: Glaucoma	0.5	0.6	0.9	0.6	1.0
Ulcerative Colitis (UC)	0.4	0.7	1.1	0.6	1.0
Body Mass Index (BMI) (2010)	0.4	0.5	1.0	0.1	-1.0
Lupus	0.4	0.6	0.7	0.7	0.9
Hypothyroidism (self reported)	0.4	0.9	1.0	-1.0	-0.9
Relative age of first facial hair	0.4	0.9	1.1	-0.8	-1.1
Ever used hormone-replacement therapy (HRT)	0.4	0.4	0.5	-0.7	-0.6
Ever had hysterectomy (womb removed)	0.4	0.5	0.6	0.6	0.8
Had other major operations	0.4	0.5	0.6	0.6	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.8	-0.3	-0.9
Hair/balding pattern: Pattern 4	0.4	0.9	1.0	-0.8	-1.0
Exposure to tobacco smoke outside home	0.4	0.5	0.6	-0.8	-0.6
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	0.5	0.7	0.7
Pulse wave peak to peak time	0.4	0.5	0.6	0.8	0.6
Eye problems/disorders: None of the above	0.4	0.4	0.5	-0.7	-0.7
Neck or shoulder pain in last month	0.4	0.6	0.6	0.7	0.8
Family relationship satisfaction	0.4	0.5	0.6	-0.6	-0.7
Leg pain on walking	0.4	0.5	0.6	-0.8	-0.6
Ever had bowel cancer screening	0.4	0.4	0.4	-0.7	-0.7
Guilty feelings	0.4	0.6	0.8	-0.6	-0.9
Mother’s age at death	0.4	0.5	0.5	0.7	0.7
Bipolar Disorder (2018)	0.3	0.5	0.7	0.8	0.6
Irritable Bowel Disease (IBD)	0.3	0.7	1.0	0.6	1.0
Prostate Cancer	0.3	0.4	0.6	0.4	0.8
Age at First Birth	0.3	0.4	0.4	0.6	0.6
Schizophrenia (2014)	0.3	0.6	1.1	-0.3	-1.1
Diabetes (father)	0.3	0.4	0.6	-0.8	-0.5
Impedance of leg (right)	0.3	1.4	1.5	-1.2	-1.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	0.6	0.5	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.1	1.1	0.3
Serious illness, injury or assault to yourself	0.3	0.3	0.4	-0.6	-0.5
Supplements: Glucosamine	0.3	0.3	0.6	0.3	0.8
Waist circumference	0.3	1.2	1.5	1.0	1.2
Ever unenthusiastic/disinterested for a whole week	0.3	0.4	0.6	-0.4	-0.8
Fluid intelligence score	0.3	0.7	1.1	0.5	1.1
Neuroticism score	0.3	0.6	0.7	-0.8	-0.7
Qualifications: O levels/GCSEs or equivalent	0.3	0.5	0.5	-0.7	-0.7
Medication: Paracetamol	0.3	0.5	0.6	-0.7	-0.7
Headache pain in last month	0.3	0.5	0.6	-0.6	-0.7
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	0.7	-0.8	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.6	-0.3	-0.8
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.3	0.3	0.5	0.7	0.4
Commuting to job workplace: Public transport	0.3	0.4	0.6	-0.4	-0.8
Medication: Paracetamol	0.3	0.5	0.5	-0.7	-0.7
Illnesses of father: High blood pressure	0.3	0.4	0.5	0.7	0.5
Ever had prostate specific antigen (PSA) test	0.3	0.4	0.6	0.8	0.3
Depressed Affect (Nagel 2018)	0.2	0.4	0.4	-0.6	-0.6
Intelligence (Savage-Jansen 2018)	0.2	0.6	1.0	0.3	1.0
Worry (Nagel 2018)	0.2	0.5	0.9	-0.9	-0.3
Primary Biliary Cirrhosis	0.2	0.3	0.6	-0.8	-0.1
Ulcerative Colitis	0.2	0.4	0.6	-0.8	-0.3
Blood White Count	0.2	1.1	1.2	-1.1	-1.0
Average weekly spirits intake	0.2	0.2	0.2	0.5	0.4
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.4	0.5	0.6
Hearing difficulty/problems: Yes	0.2	0.4	0.5	-0.7	-0.4
Medication for hormone replacement therapy	0.2	0.2	0.3	0.3	0.5
Pack years adult smoking proportion	0.2	0.4	0.7	-0.8	-0.2
Average weekly fortified wine intake	0.2	0.2	0.4	-0.7	0.0
Stomach or abdominal pain in last month	0.2	0.3	0.6	-0.2	-0.7
Trunk fat mass	0.2	1.1	1.2	1.1	1.0
Alcohol usually taken with meals	0.2	0.3	0.6	-0.8	-0.1
Mouth/teeth dental problems	0.2	0.3	0.5	-0.7	-0.4
Arm fat percentage (right)	0.2	0.8	0.9	-0.9	-0.9
Time employed in main current job	0.2	0.2	0.3	-0.6	-0.4
Father’s age at death	0.2	0.3	0.4	0.6	0.4
Depression (self-reported)	0.2	0.2	0.3	0.4	0.5
Prospective memory result	0.2	0.2	0.2	-0.5	-0.4
Pulse wave Arterial Stiffness index	0.2	0.2	0.3	-0.6	-0.3
Arm fat mass (right)	0.2	0.7	0.8	0.9	0.8
Leg fat percentage (right)	0.2	0.6	0.6	-0.8	-0.8
Wheeze or whistling in the chest in last year	0.2	0.4	0.7	0.8	0.4
Age at first live birth	0.2	0.4	0.7	-0.9	-0.3
Medication: Ibuprofen	0.2	0.2	0.3	0.5	0.4
Medication: Omeprazole	0.2	0.2	0.3	-0.6	-0.3
Whole body fat mass	0.2	0.8	0.9	0.9	0.9
Leg fat mass (right)	0.2	0.7	0.7	0.8	0.8
Suffer from ‘nerves’	0.2	0.3	0.4	0.5	0.6
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.4	0.7	0.4
Medication: Aspirin	0.2	0.3	0.4	-0.3	-0.7
Osteoporosis (self-reported)	0.2	0.2	0.3	0.5	0.4
Medication: Aspirin	0.2	0.2	0.4	-0.3	-0.6
Supplements: Fish oil (including cod liver oil)	0.2	0.2	0.2	0.5	0.5
Irritability	0.2	0.3	0.4	0.4	0.6
Cholesterol lowering medication	0.2	0.3	0.5	-0.7	-0.1
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.2	0.5	0.5
Pain experienced in last month	0.2	0.4	0.4	0.7	0.6
Supplements: Calcium	0.2	0.2	0.4	-0.1	-0.6
Pack years of smoking	0.2	0.3	0.6	-0.8	-0.1
Leg fat mass (left)	0.2	0.9	0.9	0.9	1.0
Bipolar Disorder or Schizophrenia	0.1	0.2	0.4	0.3	-0.6
Depression (Nagel 2018)	0.1	0.2	0.4	-0.6	-0.3
Neuroticism (Nagel 2018)	0.1	0.3	0.3	-0.5	-0.5
Major Depression (MDD)	0.1	0.1	0.2	0.4	0.1
Rheumatoid Arthritis	0.1	0.1	0.1	-0.3	0.2
Triglycerides	0.1	0.1	0.1	-0.3	0.3
Blood Eosinophil Count	0.1	0.8	1.5	-1.2	0.1
Blood Platelet Count	0.1	0.9	1.7	-0.2	-1.3
BMI	0.1	0.5	0.5	0.7	0.7
Allergy or Eczema	0.1	0.2	0.3	0.6	0.2
Tanning	0.1	0.8	0.8	0.8	0.9
Vitamin and mineral supplements	0.1	0.1	0.1	0.3	-0.3
Hand grip strength (right)	0.1	0.2	0.2	-0.3	-0.4
Fed-up feelings	0.1	0.2	0.3	0.4	0.5
Taking other prescription medications	0.1	0.1	0.1	-0.1	-0.4
Hayfever, allergic rhinitis or eczema	0.1	0.2	0.3	0.5	0.1
Multivitamins +/- minerals	0.1	0.1	0.1	-0.4	-0.2
Impedance of leg (left)	0.1	0.5	0.5	-0.7	-0.7
Frequency of tenseness / restlessness in last 2 weeks	0.1	0.2	0.2	0.5	0.5
Had menopause	0.1	0.1	0.1	-0.4	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.3	0.6	0.8	-0.2
Qualifications: None of the above	0.1	0.3	0.3	0.5	0.6
Heart attack	0.1	0.1	0.2	-0.5	-0.1
Medication: Ramipril	0.1	0.1	0.3	-0.5	-0.1
Hip circumference	0.1	0.6	0.7	0.8	0.8
Worrier / anxious feelings	0.1	0.2	0.4	-0.6	-0.2
Happiness	0.1	0.2	0.2	-0.4	-0.4
Qualifications: A levels/AS levels or equivalent	0.1	0.1	0.2	0.5	0.2
Medication: Ibuprofen (e.g. Nurofen)	0.1	0.2	0.2	0.5	0.3
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.2	-0.2	-0.4
Peak expiratory flow (PEF)	0.1	0.2	0.4	0.6	0.1
Body fat percentage	0.1	0.3	0.3	-0.5	-0.6
Worry too long after embarrassment	0.1	0.1	0.2	-0.3	-0.4
Mouth/teeth dental problems: Loose teeth	0.1	0.1	0.2	-0.4	-0.2
Medication for pain relief, constipation, heartburn	0.1	0.2	0.4	0.3	0.6
Migraine (self-reported)	0.1	0.2	0.2	-0.5	-0.3
Chest pain or discomfort	0.1	0.1	0.2	-0.2	-0.5
Age at last live birth	0.1	0.1	0.1	-0.3	0.3
Long-standing illness, disability or infirmity	0.1	0.2	0.4	-0.6	-0.1
Ever had stillbirth, spontaneous miscarriage or termination	0.1	0.1	0.2	0.4	0.2
Back pain experienced in last month	0.1	0.1	0.2	-0.4	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.1	0.2	0.3	0.6	0.0
High cholesterol (Self-reported)	0.1	0.2	0.2	-0.4	-0.5
Alcohol drinker status: Never	0.1	0.1	0.2	-0.4	-0.2
Leg fat percentage (left)	0.1	0.2	0.2	-0.4	-0.5
Number of operations (self-reported)	0.1	0.2	0.2	0.5	0.4
Ever depressed for a whole week	0.1	0.2	0.3	-0.1	-0.6
Commuting to job workplace: Cycle	0.1	0.2	0.3	-0.6	-0.1
Myopia	0.1	0.1	0.2	-0.4	-0.3
Alcohol drinker status: Previous	0.1	0.1	0.2	0.4	0.3
Alzheimer’s Disease (in father)	0.0	0.0	0.1	-0.0	-0.2
Ovarian Cancer	0.0	0.1	0.1	-0.1	-0.3
LDL Cholesterol	0.0	0.0	0.0	-0.0	0.1
Neuroticism (2016)	0.0	0.0	0.0	-0.2	0.0
Type 2 Diabetes (T2D) (2012)	0.0	0.0	0.1	-0.2	0.1
Lung FEV1/FVC ratio	0.0	0.0	0.1	0.0	-0.2
Chronotype (morning person)	0.0	0.0	0.0	0.2	0.2
Hair Pigment	0.0	0.1	0.2	0.5	0.2
Hand grip strength (left)	0.0	0.0	0.0	-0.1	-0.1
Trunk fat percentage	0.0	0.0	0.0	-0.0	-0.2
Relative age voice broke	0.0	0.0	0.1	0.1	-0.2
Tinnitus: Yes, but not now, but have in the past	0.0	0.0	0.0	-0.1	0.1
Qualifications: CSEs or equivalent	0.0	0.1	0.1	0.3	0.1
Body mass index (BMI)	0.0	0.0	0.0	0.1	0.0
Hair/balding pattern: Pattern 2	0.0	0.0	0.0	0.1	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.0	0.0	0.0	-0.0	-0.1
Number of live births	0.0	0.0	0.0	0.0	-0.2
Mouth/teeth dental problems: Dentures	0.0	0.1	0.1	0.3	-0.2
Tense / ‘highly strung’	0.0	0.0	0.0	0.0	0.1
Mouth/teeth dental problems: Bleeding gums	0.0	0.0	0.1	-0.3	-0.1
Chronic bronchitis/emphysema (mother)	0.0	0.0	0.0	-0.1	-0.1
Comparative body size at age 10	0.0	0.1	0.1	0.3	0.3
Health satisfaction	0.0	0.0	0.0	-0.2	0.1
Qualifications: College or University degree	0.0	0.1	0.1	0.2	-0.3
Medication: Allopurinol	0.0	0.0	0.0	-0.2	-0.1
Pulse rate, automated reading	0.0	0.1	0.1	0.3	0.2
Alcohol intake frequency.	0.0	0.1	0.2	-0.5	-0.1
Overall health rating	0.0	0.0	0.1	-0.2	0.2
Illnesses of father: Heart disease	0.0	0.0	0.0	-0.2	-0.2
Mood swings	0.0	0.0	0.0	0.1	0.0
Loneliness, isolation	0.0	0.1	0.1	0.1	0.3
Friendships satisfaction	0.0	0.0	0.0	0.0	0.0
Qualifications: nursing, teaching	0.0	0.0	0.1	0.0	-0.3
Commuting to job workplace: Walk	0.0	0.0	0.0	-0.0	-0.0
Mineral and other dietary supplements	0.0	0.0	0.1	0.1	0.3
Osteoarthritis (self-reported)	0.0	0.0	0.0	-0.2	0.1
Illnesses of father: None of the above (group 1)	0.0	0.0	0.0	-0.1	0.2
Arm fat mass (left)	0.0	0.1	0.2	0.4	0.3
Miserableness	0.0	0.0	0.0	0.1	-0.1
Ever taken oral contraceptive pill	0.0	0.0	0.1	-0.3	0.0
Unable to work because of sickness or disability	0.0	0.1	0.1	0.0	0.3
Heart attack/myocardial infarction (self-reported)	0.0	0.1	0.1	-0.3	0.1

Hub : Genes

ACSM3

Models

Trait associations