Best TWAS P=6.62e-18 · Best GWAS P=6.94e-11 conditioned to 0.347
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Esophagus Muscularis | MARCH2 | 0.34 | 0.30 | enet | 22 | 0.32 | 6.9e-20 | 4.4 | 5.3 | 9.7e-08 | -0.19 | 0.97 | 0.03 | FALSE |
| 2 | GTEx | Esophagus Muscularis | ZNF414 | 0.18 | 0.09 | lasso | 3 | 0.07 | 3.2e-05 | -4.7 | -5.3 | 1.3e-07 | 0.69 | 0.07 | 0.92 | FALSE |
| 3 | GTEx | Skin Not Sun Exposed Suprapubic | MARCH2 | 0.42 | 0.33 | enet | 27 | 0.35 | 5.6e-20 | 4.8 | 5.3 | 1.3e-07 | -0.15 | 0.95 | 0.05 | FALSE |
| 4 | NTR | Blood | PRAM1 | 0.04 | 0.02 | bslmm | 351 | 0.02 | 1.1e-06 | 4.6 | -5.1 | 2.8e-07 | 0.21 | 0.97 | 0.02 | FALSE |
| 5 | ROSMAP | Brain Pre-frontal Cortex | PRAM1 | 0.04 | 0.00 | enet | 15 | 0.01 | 4.5e-02 | 3.9 | -5.4 | 6.2e-08 | 0.05 | 0.16 | 0.03 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MYO1F | 0.05 | 0.01 | blup | 42 | 0.03 | 2.2e-04 | -6.5 | -8.6 | 6.6e-18 | 0.68 | 0.00 | 0.94 | TRUE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | PRAM1 | 0.03 | 0.01 | blup | 44 | 0.01 | 7.3e-02 | 4.6 | -5.8 | 6.3e-09 | 0.49 | 0.03 | 0.26 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ZNF414 | 0.04 | 0.01 | blup | 39 | 0.02 | 1.9e-03 | -4.8 | -5.5 | 3.9e-08 | 0.70 | 0.18 | 0.50 | FALSE |
| 9 | The Cancer Genome Atlas | Stomach Adenocarcinoma | PRAM1 | 0.05 | 0.02 | blup | 44 | 0.01 | 3.4e-02 | -4.8 | -6.3 | 2.3e-10 | 0.70 | 0.01 | 0.74 | FALSE |
| 10 | The Cancer Genome Atlas | Thyroid Carcinoma | MARCH2 | 0.19 | 0.09 | blup | 42 | 0.14 | 9.3e-14 | 4.7 | 5.1 | 2.9e-07 | -0.19 | 0.00 | 0.98 | FALSE |