Best TWAS P=1.96e-21 · Best GWAS P=3.22e-19 conditioned to 0.89
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | S1PR2 | 0.07 | 0.02 | bslmm | 369 | 0.03 | 5.3e-05 | -4.7 | 5.6 | 1.7e-08 | 0.31 | 0.32 | 0.14 | TRUE |
| 2 | GTEx | Adipose Subcutaneous | ILF3-AS1 | 0.18 | 0.05 | enet | 27 | 0.12 | 1.2e-09 | -3.6 | -7.3 | 2.1e-13 | -0.49 | 0.13 | 0.76 | FALSE |
| 3 | GTEx | Adipose Visceral Omentum | S1PR2 | 0.23 | 0.01 | lasso | 5 | 0.01 | 1.1e-01 | -3.7 | 5.1 | 2.7e-07 | 0.10 | 0.06 | 0.24 | FALSE |
| 4 | GTEx | Artery Aorta | ILF3-AS1 | 0.13 | 0.05 | lasso | 6 | 0.06 | 4.5e-04 | -5.0 | -5.3 | 1.0e-07 | -0.16 | 0.37 | 0.28 | FALSE |
| 5 | GTEx | Esophagus Mucosa | SLC44A2 | 0.13 | 0.00 | lasso | 6 | 0.02 | 1.4e-02 | 4.1 | -5.7 | 1.6e-08 | -0.46 | 0.06 | 0.65 | FALSE |
| 6 | GTEx | Esophagus Mucosa | ILF3-AS1 | 0.11 | 0.00 | lasso | 4 | 0.00 | 2.5e-01 | 9.0 | -9.5 | 2.0e-21 | -0.77 | 0.01 | 0.91 | TRUE |
| 7 | GTEx | Heart Left Ventricle | ILF3-AS1 | 0.16 | 0.06 | lasso | 9 | 0.04 | 3.1e-03 | -5.0 | -5.9 | 3.9e-09 | -0.16 | 0.13 | 0.05 | FALSE |
| 8 | GTEx | Lung | ILF3-AS1 | 0.11 | 0.10 | lasso | 4 | 0.09 | 1.8e-07 | -5.0 | -6.2 | 6.5e-10 | -0.26 | 0.82 | 0.13 | FALSE |
| 9 | GTEx | Muscle Skeletal | SLC44A2 | 0.19 | 0.18 | lasso | 5 | 0.19 | 5.1e-18 | 6.7 | 7.4 | 1.8e-13 | 0.79 | 0.81 | 0.19 | FALSE |
| 10 | GTEx | Nerve Tibial | ILF3-AS1 | 0.14 | 0.04 | lasso | 3 | 0.08 | 3.8e-06 | 8.8 | -9.3 | 1.7e-20 | -0.77 | 0.01 | 0.98 | FALSE |
| 11 | GTEx | Skin Sun Exposed Lower leg | ILF3-AS1 | 0.14 | 0.08 | enet | 14 | 0.06 | 5.9e-06 | -5.0 | -6.1 | 1.1e-09 | -0.35 | 0.92 | 0.06 | FALSE |
| 12 | GTEx | Whole Blood | SLC44A2 | 0.11 | 0.01 | enet | 30 | 0.02 | 5.2e-03 | 6.6 | -5.4 | 6.5e-08 | -0.60 | 0.02 | 0.90 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | ILF3-AS1 | 0.15 | 0.04 | bslmm | 354 | 0.18 | 7.1e-22 | -3.6 | -8.1 | 5.0e-16 | -0.61 | 0.05 | 0.95 | FALSE |
| 14 | The Cancer Genome Atlas | Breast Invasive Carcinoma | S1PR2 | 0.02 | 0.00 | blup | 32 | 0.01 | 1.5e-02 | -4.7 | 5.5 | 4.7e-08 | 0.04 | 0.01 | 0.19 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | LOC147727 | 0.13 | 0.02 | blup | 28 | 0.04 | 7.2e-05 | 8.8 | -8.9 | 8.1e-19 | -0.76 | 0.01 | 0.88 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LOC147727 | 0.07 | 0.02 | lasso | 2 | 0.02 | 5.4e-03 | 9.0 | -8.9 | 5.0e-19 | -0.99 | 0.01 | 0.88 | FALSE |
| 17 | The Cancer Genome Atlas | Thyroid Carcinoma | LOC147727 | 0.24 | 0.02 | enet | 18 | 0.07 | 6.1e-07 | 6.7 | -6.1 | 9.3e-10 | -0.35 | 0.01 | 0.21 | FALSE |
| 18 | The Cancer Genome Atlas | Thyroid Carcinoma | SLC44A2 | 0.32 | 0.22 | enet | 14 | 0.25 | 3.8e-24 | 7.3 | 5.9 | 3.4e-09 | 0.85 | 1.00 | 0.00 | FALSE |