TWAS hub - S1PR2

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0680	0.0230	0.00057	0.018	0.031	0.029	0.034	0.028	0.0022	0.00011	0.00017	5.2e-05	0.00018
2	GTEx	Adipose Visceral Omentum	0.2330	0.0670	0.00023	0.010	NA	-0.002	NA	0.009	0.0910	NA	0.44000	NA	0.11000
3	TCGA	Breast Invasive Carcinoma	0.0182	0.0115	0.00960	0.005	0.006	0.003	NA	0.005	0.0320	0.01400	0.05700	NA	0.03300

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Birth weight	8.8	19.2	22.4	4.7	4.1	4.3
Standing height	6.5	64.6	71.6	7.8	7.8	8.5
Trunk predicted mass	6.1	35.1	39.9	6.3	5.1	6.3
Health satisfaction	6.1	8.0	12.5	1.6	3.0	3.5
Trunk fat-free mass	6.0	34.3	39.7	6.3	5.0	6.2
Commuting to job workplace: Public transport	6.0	7.2	13.8	2.4	1.4	3.7
Arm fat-free mass (left)	5.6	28.4	33.3	5.6	4.5	5.8
Arm predicted mass (left)	5.5	28.0	32.4	5.6	4.5	5.7
Systolic Blood Pressure	5.4	26.9	49.7	-7.0	-5.2	-2.1
Whole body fat-free mass	5.3	30.3	34.1	5.7	5.0	5.8
Whole body water mass	5.3	30.0	33.2	5.7	5.0	5.8
Arm fat-free mass (right)	5.2	26.5	31.7	5.6	4.2	5.5
Blood White Count	4.9	36.2	43.4	-6.2	-6.6	-5.1
Birth weight of first child	4.9	8.8	9.6	3.1	3.1	2.7
Basal metabolic rate	4.9	27.0	30.1	5.3	4.8	5.5
Height	4.8	93.3	108.2	9.6	8.9	10.4
Systolic blood pressure, automated reading	4.8	13.8	26.1	-5.1	-3.7	-1.3
Arm predicted mass (right)	4.7	24.0	29.4	5.3	3.9	5.4
Comparative height size at age 10	4.5	24.8	27.6	5.1	4.5	5.3
Forced expiratory volume in 1-second (FEV1), Best measure	4.4	14.0	19.3	4.4	3.2	3.6
Commuting to job workplace: Car/motor vehicle	4.4	5.1	14.1	-0.5	-0.9	-3.8
Leg fat-free mass (left)	4.1	21.6	22.6	4.5	4.8	4.7
Sitting height	4.1	29.4	31.8	5.6	5.1	5.5
Leg predicted mass (left)	4.0	21.2	21.9	4.5	4.7	4.7
Forced expiratory volume in 1-second (FEV1), predicted	4.0	8.3	13.3	2.4	3.7	2.5
Family relationship satisfaction	3.8	4.7	6.4	1.8	2.5	2.1
Leg predicted mass (right)	3.8	20.3	21.5	4.3	4.5	4.6
Leg fat-free mass (right)	3.7	19.9	20.7	4.3	4.5	4.6
High blood pressure	3.6	10.0	18.9	-4.3	-3.2	-0.8
Medication: Atenolol	3.5	4.4	7.3	-2.4	-2.7	-0.2
Medication: Ibuprofen (e.g. Nurofen)	3.5	4.4	8.0	1.7	1.6	2.8
Friendships satisfaction	3.5	4.3	7.4	2.7	2.1	1.1
Medication: Amlodipine	3.4	4.8	9.7	-3.1	-1.6	-1.5
Hypertension (Self-reported)	3.3	9.1	17.5	-4.2	-3.0	-0.8
Medication: Blood pressure	3.3	6.3	13.5	-3.7	-1.8	-1.5
Forced expiratory volume in 1-second (FEV1)	3.2	10.9	15.0	3.9	3.2	2.8
Medication: Allopurinol	3.2	4.3	6.5	-2.5	-2.1	-1.5
Vascular/heart problems diagnosed by doctor	3.2	8.8	17.6	4.2	3.0	0.1
Hearing difficulty/problems with background noise	3.0	4.7	7.6	2.8	1.5	2.1
Forced vital capacity (FVC), Best measure	3.0	10.8	13.8	3.7	3.1	3.0
Lung FEV1/FVC ratio	2.9	14.9	20.2	4.5	3.1	3.9
Weight	2.9	14.5	16.0	3.9	3.5	4.0
Medication: Bendroflumethiazide	2.9	4.4	6.8	-2.4	-2.6	-0.9
Chronic bronchitis/emphysema (father)	2.8	3.2	4.8	-1.4	-1.7	-2.2
Happiness	2.8	3.3	4.8	1.6	2.2	1.6
Breast cancer (self-reported)	2.8	3.3	5.8	2.0	2.4	0.3
Osteoporosis (self-reported)	2.8	3.4	4.9	-1.6	-2.2	-1.7
Prostate Cancer	2.7	3.8	4.8	2.2	2.1	1.4
Qualifications: None of the above	2.6	5.5	11.3	-1.4	-1.8	-3.4
Average weekly fortified wine intake	2.5	2.9	6.1	-1.2	-2.5	1.1
Medication: Ibuprofen	2.5	3.0	5.0	1.7	1.0	2.2
Number of full sisters	2.5	3.0	7.1	1.3	2.7	0.5
Illnesses of father: None of the above (group 1)	2.5	3.1	7.5	2.7	1.3	0.2
Rheumatoid Arthritis	2.4	3.3	5.5	-1.2	-2.3	-1.8
Medication for cholesterol, blood pressure or diabetes	2.4	4.0	7.4	2.7	1.8	-1.0
Major Depression (MDD)	2.3	2.7	8.0	0.5	2.8	0.0
Qualifications: CSEs or equivalent	2.3	3.1	6.4	0.9	2.5	-1.4
Cardiovascular Disease	2.2	7.4	14.2	-3.8	-2.7	-0.7
Noisy workplace	2.2	2.8	4.7	1.9	2.2	-0.2
Medication: Blood pressure	2.2	3.8	5.7	-2.4	-2.4	0.4
Number of self-reported non-cancer illnesses	2.2	3.9	5.9	-2.2	-2.4	-0.8
Forced vital capacity (FVC)	2.1	8.2	9.5	3.1	2.9	2.6
Qualifications: O levels/GCSEs or equivalent	2.1	3.4	8.8	3.0	1.1	0.4
Peak expiratory flow (PEF)	2.0	4.6	6.2	2.5	2.1	1.8
Knee pain experienced in last month	2.0	3.1	5.7	2.4	1.4	-1.2
Mean Putamen Volume	1.9	2.2	4.7	2.2	1.3	-0.5
LDL Cholesterol	1.9	3.0	6.5	-0.9	1.3	2.5
Severe depression (siblings)	1.9	2.1	3.5	0.4	1.6	1.9
Medication: Cholesterol lowering	1.9	2.9	3.7	-1.9	-1.2	1.9
High blood pressure (siblings)	1.9	2.8	6.5	-2.5	-1.2	-0.5
Chest pain or discomfort	1.9	2.8	3.8	1.8	1.9	1.2
Crohns Disease (2017)	1.8	3.9	7.2	-2.7	1.9	0.9
Number of children fathered	1.8	2.0	2.6	1.4	1.2	1.6
Irritable Bowel Disease (IBD)	1.7	4.0	7.9	-2.8	0.9	1.9
Ulcerative Colitis	1.7	2.5	4.5	-1.6	-0.7	2.1
Medication: Co-codamol	1.7	1.9	2.7	1.6	0.7	1.6
Financial difficulties in last 2 years	1.7	2.3	5.5	2.3	1.1	-0.4
Mouth/teeth dental problems: Loose teeth	1.7	2.0	2.6	1.1	1.4	-1.6
Pain type(s) experienced in last month: Hip pain	1.7	2.1	3.3	-1.7	-0.5	-1.8
Heart disease (siblings)	1.7	2.1	4.5	-2.1	-1.3	-0.4
Ever used hormone-replacement therapy (HRT)	1.6	2.0	4.6	-2.1	-1.1	0.5
Qualifications: A levels/AS levels or equivalent	1.6	3.6	6.8	1.8	0.9	2.6
Gout (self-reported)	1.6	2.2	3.5	-1.0	-1.5	-1.9
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.1	2.8	-1.7	-1.1	-1.5
Qualifications: nursing, teaching	1.6	2.4	4.5	2.1	1.1	1.3
Medication for cholesterol	1.6	2.5	4.6	2.1	1.2	1.2
Angina	1.5	1.9	5.4	-2.3	0.3	0.5
Medication: Metformin	1.5	2.1	5.9	-0.7	-2.4	-0.2
Glaucoma (self-reported)	1.5	1.8	4.6	0.8	2.1	0.5
Leg pain on walking	1.5	1.9	4.5	1.1	2.1	0.3
Number of treatments/medications taken	1.4	2.6	4.2	-1.9	-2.0	-0.0
Length of working week for main job	1.4	1.6	4.4	-0.6	-0.1	-2.1
Number of full brothers	1.4	1.7	2.6	0.9	1.6	-1.3
Osteoarthritis (self-reported)	1.4	1.8	2.4	1.0	-1.5	-1.4
Ovarian Cancer	1.3	1.8	2.9	-1.7	-1.0	-1.2
Crohns Disease (2012)	1.3	2.1	4.5	-2.1	1.1	0.7
Diabetes (father)	1.3	1.7	3.0	-1.1	-0.8	-1.7
Maternal smoking around birth	1.3	1.9	5.5	0.2	0.3	2.4
Hair/balding pattern: Pattern 2	1.3	1.6	4.3	-0.1	0.7	2.1
Illnesses of mother	1.3	1.6	2.5	1.4	1.6	-0.4
Qualifications: College or University degree	1.3	4.1	7.4	0.8	-2.1	2.7
Eye problems/disorders: Glaucoma	1.3	1.5	4.1	0.3	2.0	0.4
High cholesterol (Self-reported)	1.3	2.4	3.4	-1.6	-1.8	1.1
Schizophrenia vs Biploar Disorder	1.2	1.6	3.5	1.9	-1.2	0.0
Ulcerative Colitis (UC)	1.2	2.2	4.0	-1.6	-0.3	2.0
Fasting Glucose	1.2	1.5	3.2	1.1	1.8	-0.4
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	4.3	0.0	2.1	0.0
High blood pressure (mother)	1.2	1.7	5.0	-2.2	0.0	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.2	1.9	2.8	1.2	1.7	-1.2
Medication: Simvastatin	1.2	1.7	3.2	-1.8	-1.2	0.7
Illnesses of siblings	1.2	1.7	3.5	1.9	1.3	0.3
Hip circumference	1.2	5.2	8.6	2.9	2.1	1.5
Blood clot in the leg (DVT)	1.2	1.5	2.4	-1.3	1.6	-0.6
Qualifications: NVQ or HND or HNC or equivalent	1.2	1.4	3.8	-0.4	1.9	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.4	-0.6	0.7	1.9
Illnesses of father: Heart disease	1.2	1.7	2.9	-1.7	-1.5	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.2	1.4	1.9	1.4	1.3	0.8
Ever taken oral contraceptive pill	1.2	1.3	2.9	-1.7	0.3	-1.0
Coronary Artery Disease (CAD)	1.1	1.3	3.1	-1.8	0.9	0.0
Hearing difficulty/problems: Yes	1.1	1.7	3.6	1.9	1.2	0.4
Hand grip strength (right)	1.1	2.9	4.0	0.9	2.0	2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.1	1.5	4.4	0.3	-0.1	-2.1
Alcohol usually taken with meals	1.1	1.8	3.1	1.8	0.8	1.3
Mouth/teeth dental problems	1.1	1.6	4.2	0.3	-0.7	2.1
Pain all over the body in last month	1.1	1.2	3.0	1.7	-0.3	0.7
Ever highly irritable/argumentative for 2 days	1.1	1.3	2.3	0.5	1.5	1.2
Worry too long after embarrassment	1.1	1.9	5.2	0.2	0.7	2.3
Emphysema/chronic bronchitis	1.1	1.3	3.8	-2.0	-0.1	-0.0
Angina (self-reported)	1.1	1.4	4.1	-2.0	0.1	0.3
Smoking status: Previous	1.1	1.7	3.3	1.1	1.8	0.7
Eye problems/disorders: Cataract	1.1	1.3	3.3	-0.3	0.7	1.8
Medication: Gliclazide	1.1	1.2	2.7	1.6	-0.1	0.9
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.4	-1.2	1.6	-0.6
Respiratory disease	1.0	2.3	4.6	-1.3	-0.7	-2.1
Chronotype (morning person)	1.0	2.3	4.8	-1.2	0.8	2.2
Fed-up feelings	1.0	1.9	3.1	1.6	1.8	-0.2
Trunk fat mass	1.0	4.3	6.5	1.6	2.0	2.5
Age at first live birth	1.0	1.8	3.9	0.6	1.0	2.0
Eye problems/disorders: None of the above	1.0	1.1	2.4	-0.6	-1.5	-0.8
Heart disease (mother)	1.0	1.2	1.7	-1.3	-1.3	-0.4
Alcohol intake frequency.	1.0	2.2	3.3	-1.8	-0.6	-1.7
Supplements: Vitamin C	1.0	1.2	1.6	-1.3	-0.9	-1.1
Long-standing illness, disability or infirmity	1.0	1.5	2.0	-1.3	-0.9	-1.4
Medication: Omeprazole (e.g. Zanprol)	1.0	1.2	2.1	1.2	1.5	0.4
Pack years adult smoking proportion	0.9	1.3	3.4	0.7	1.8	0.4
Supplements: Glucosamine	0.9	1.1	1.2	1.0	1.0	1.1
Had menopause	0.9	1.1	2.9	0.6	-0.4	1.7
Ever unenthusiastic/disinterested for a whole week	0.9	1.1	3.3	0.2	1.8	-0.0
Worrier / anxious feelings	0.9	1.8	3.6	-1.3	0.1	1.9
Exposure to tobacco smoke outside home	0.9	1.2	2.4	-0.9	-0.4	-1.6
Medication: Aspirin	0.9	1.1	2.5	-0.3	-0.9	1.6
Handedness (chirality/laterality): Left-handed	0.9	1.1	1.5	-0.8	-1.2	-1.0
Medication: Atorvastatin	0.9	1.1	1.8	-0.9	-1.4	0.7
Diastolic blood pressure, automated reading	0.9	2.8	3.4	-1.9	-1.7	1.4
Lupus	0.8	1.1	2.8	-1.7	-0.5	-0.6
Relative age voice broke	0.8	1.2	2.5	-1.0	0.5	1.6
Depression (self-reported)	0.8	0.9	1.4	-1.1	0.0	-1.2
Tense / ‘highly strung’	0.8	1.3	2.9	-0.4	1.7	0.9
Headache pain in last month	0.8	1.3	3.2	-0.8	-1.8	-0.0
Medication: Ventolin 100micrograms inhaler	0.8	1.0	2.5	-0.7	-0.1	-1.6
Reason for reducing amount of alcohol drunk: Health precaution	0.8	0.9	1.5	-0.9	-0.7	1.2
Whole body fat mass	0.8	3.3	5.6	1.3	1.6	2.4
Ever had bowel cancer screening	0.8	0.9	1.8	-1.3	-0.4	-0.9
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.5	-0.5	1.6	0.1
Arm fat mass (left)	0.8	3.3	4.3	1.6	1.8	2.1
Wears glasses or contact lenses	0.8	1.0	2.0	0.6	-0.7	1.4
Financial situation satisfaction	0.8	0.9	1.2	1.1	1.1	0.7
Fractured/broken bones in last 5 years	0.8	1.0	2.7	1.6	-0.6	-0.1
Unable to work because of sickness or disability	0.8	1.0	2.3	0.8	1.5	-0.1
Triglycerides	0.7	1.1	2.2	-1.0	-1.5	0.3
Smoking Status	0.7	1.8	3.0	1.5	1.7	0.2
Average weekly spirits intake	0.7	0.9	1.4	1.2	1.2	0.1
Serious illness, injury or assault to yourself	0.7	0.9	1.4	-0.5	1.2	-1.0
Number of incorrect matches in round	0.7	1.1	1.8	0.3	1.3	1.2
Medication: Lansoprazole	0.7	0.7	1.0	0.7	0.9	1.0
Hair/balding pattern: Pattern 4	0.7	1.7	4.1	-0.2	-0.9	-2.0
Medication: Seretide 50 evohaler	0.7	0.8	1.1	-1.0	1.1	-0.3
Leg fat mass (right)	0.7	2.8	3.5	1.8	1.3	1.9
Illness, injury, bereavement, stress in last 2 years	0.7	0.9	2.0	-0.4	-0.7	1.4
Diabetes diagnosed by doctor	0.7	1.2	2.5	0.7	-1.6	0.7
Mouth/teeth dental problems: Mouth ulcers	0.7	1.0	1.3	1.0	1.2	-0.9
Tinnitus: Yes, now most or all of the time	0.7	0.8	1.3	1.0	1.2	0.4
Bipolar Disorder (2018)	0.6	1.0	1.1	-1.1	0.9	1.0
Alzheimer’s Disease (in mother)	0.6	0.8	1.2	-0.8	-1.1	0.6
Breast Cancer	0.6	1.4	2.9	-1.0	-1.7	0.6
Neuroticism (2016)	0.6	0.9	2.6	-0.3	-0.2	1.6
Schizophrenia (2014)	0.6	1.3	2.7	0.7	-0.8	-1.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.7	1.6	0.0	-1.3	-0.8
Diabetes (mother)	0.6	0.8	1.6	1.3	-0.3	0.8
Past tobacco smoking	0.6	1.1	2.6	-0.7	-1.6	-0.3
Hayfever/allergic rhinitis (self-reported)	0.6	0.7	1.1	-0.8	-1.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	1.8	0.5	1.3	0.9
Mouth/teeth dental problems: Bleeding gums	0.6	0.7	1.5	-0.5	1.2	-0.7
Medication: Aspirin	0.6	0.8	1.3	-0.5	-1.2	0.8
Alcohol drinker status: Never	0.6	0.8	1.9	-0.6	0.3	-1.4
Ever smoked	0.6	1.1	2.1	0.7	1.4	0.8
Risk taking	0.6	0.9	2.1	0.6	-0.2	1.5
Commuting to job workplace: Cycle	0.6	0.7	2.0	0.3	-1.4	-0.3
Heart attack/myocardial infarction (self-reported)	0.6	0.7	1.5	-1.2	-0.6	0.5
Pack years of smoking	0.6	0.9	2.7	0.3	1.6	0.1
Reaction Time	0.5	0.9	1.2	-0.9	0.7	-1.1
HbA1C	0.5	0.6	1.6	-0.2	-0.1	-1.3
Allergy or Eczema	0.5	1.4	2.1	-1.4	-1.5	0.3
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	0.6	0.7	0.7	-0.8
Medication for hormone replacement therapy	0.5	0.6	1.1	-0.8	-0.2	-1.0
Taking other prescription medications	0.5	0.8	1.3	-1.2	-1.0	-0.2
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.1	-1.1	-1.5	0.1
Heart attack	0.5	0.6	1.3	-1.2	-0.4	0.7
Allergy	0.5	1.2	2.2	1.5	1.2	0.1
Diabetes (self-reported)	0.5	0.7	1.8	0.4	-1.4	0.4
Frequency of tiredness / lethargy in last 2 weeks	0.5	0.9	2.1	0.2	0.6	-1.5
Pulse wave Arterial Stiffness index	0.5	0.6	1.3	-0.6	0.0	1.2
Arm fat mass (right)	0.5	2.1	2.9	1.0	1.5	1.7
Exposure to tobacco smoke at home	0.5	0.6	1.1	1.1	0.7	-0.4
Breastfed as a baby	0.5	0.6	1.1	0.6	1.0	0.6
Pulse wave reflection index	0.5	0.6	1.2	-0.2	0.8	1.1
Pulse wave peak to peak time	0.5	0.6	1.3	1.1	0.5	-0.6
Shortness of breath walking on level ground	0.5	0.7	1.8	0.3	-0.3	1.3
Medication for pain relief, constipation, heartburn	0.5	0.9	2.6	-0.1	-0.1	-1.6
Neck or shoulder pain in last month	0.5	0.7	1.1	0.8	1.0	-0.6
Age at last live birth	0.5	0.8	2.2	0.2	0.4	1.5
Smoking status: Current	0.5	0.8	1.5	0.8	1.2	-0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.1	1.4	0.9	0.4
Number of operations (self-reported)	0.5	0.7	1.5	0.9	1.2	0.0
Leg fat mass (left)	0.5	2.0	2.8	1.5	1.0	1.7
Depressed Affect (Nagel 2018)	0.4	0.9	2.2	0.7	1.5	0.1
Depression (Nagel 2018)	0.4	0.6	1.9	-0.1	-0.1	-1.4
Intelligence (Savage-Jansen 2018)	0.4	1.1	1.8	0.8	0.9	1.3
HDL Cholesterol	0.4	0.7	1.6	0.6	0.3	-1.3
Primary Biliary Cirrhosis	0.4	0.5	0.5	-0.7	-0.7	-0.7
Frequency of depressed mood in last 2 weeks	0.4	0.5	1.2	0.1	-0.6	-1.1
Waist circumference	0.4	1.6	2.2	1.5	0.8	1.4
Nervous feelings	0.4	0.8	1.4	-0.9	-1.2	-0.3
Had other major operations	0.4	0.5	1.2	0.2	-0.4	-1.1
Impedance of arm (right)	0.4	2.1	4.8	-2.2	0.6	-1.0
Hair/balding pattern: Pattern 3	0.4	0.6	1.6	-0.5	-0.1	-1.3
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.5	1.0	-0.5	0.5	1.0
Impedance of arm (left)	0.4	1.7	3.8	-2.0	0.3	-1.1
Medication: Omeprazole	0.4	0.5	1.1	0.5	1.1	-0.2
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.4	0.5	1.5	-0.1	-1.2	0.1
Illnesses of siblings: Diabetes	0.4	0.5	0.9	-0.3	-1.0	0.7
Loneliness, isolation	0.4	0.6	1.1	0.1	0.8	-1.1
Asthma (self-reported)	0.4	0.9	2.1	-0.7	-0.1	-1.5
Miserableness	0.4	0.7	1.5	-0.1	1.2	-0.9
Irritability	0.4	0.6	0.8	0.8	0.9	-0.7
Ever had prostate specific antigen (PSA) test	0.4	0.4	0.8	0.1	-0.9	0.7
Neuroticism (Nagel 2018)	0.3	0.7	1.4	0.0	1.2	0.8
Worry (Nagel 2018)	0.3	0.6	1.2	-0.5	0.5	1.1
Alzheimer’s Disease (including proxy)	0.3	0.5	0.9	-0.7	-0.9	0.3
Body Mass Index (BMI) (2010)	0.3	0.4	0.6	-0.8	-0.7	0.1
Type 2 Diabetes (T2D) (2012)	0.3	0.3	0.5	-0.5	-0.5	-0.7
Heel T-Score	0.3	2.5	3.6	-0.8	-1.8	-1.9
Waist Hip Ratio (WHR)	0.3	1.2	2.3	-0.9	-1.5	0.6
Hypothyroidism (self reported)	0.3	0.7	1.8	-0.3	-0.4	1.4
Tanning	0.3	4.2	7.6	2.1	2.8	0.8
Hand grip strength (left)	0.3	0.7	1.0	-0.5	1.0	0.9
Current tobacco smoking	0.3	0.5	1.1	0.5	1.0	-0.2
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.7	1.3	1.1	0.5	-0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.0	0.4	-1.0	-0.2
Medication: Levothyroxine sodium	0.3	0.5	1.3	-1.1	-0.3	0.1
Neuroticism score	0.3	0.5	1.4	-0.4	1.2	-0.0
Alcohol intake versus 10 years previously	0.3	0.4	1.0	0.5	0.2	-1.0
Number of live births	0.3	0.4	1.0	-0.2	-0.5	-1.0
Pulse rate	0.3	0.4	1.1	-1.0	-0.1	-0.5
Asthma	0.3	0.5	1.2	-0.6	-0.1	-1.1
Prospective memory result	0.3	0.3	0.9	0.9	-0.2	0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.5	1.5	0.2	-0.0	1.2
Migraine (self-reported)	0.3	0.4	0.9	1.0	0.3	0.3
Overall health rating	0.3	0.7	1.4	0.6	1.2	-0.5
Commuting to job workplace: Walk	0.3	0.3	0.8	-0.9	-0.4	0.2
Cholesterol lowering medication	0.3	0.4	0.9	-0.1	-1.0	0.6
Basal cell carcinoma (self-reported)	0.3	0.3	0.7	0.8	0.3	0.4
Schizophrenia (2018)	0.2	0.4	0.7	0.8	0.4	-0.6
Verbal and Numeric Reasoning (VNR)	0.2	0.6	0.9	1.0	0.4	0.8
BMI	0.2	1.2	1.4	1.2	0.9	1.2
Type 2 Diabetes (T2D) (2018)	0.2	0.3	1.0	0.2	-1.0	0.0
Relative age of first facial hair	0.2	0.5	0.9	-0.5	0.5	1.0
Ever had hysterectomy (womb removed)	0.2	0.3	0.5	-0.0	0.7	-0.6
Supplements: Zinc	0.2	0.2	0.5	-0.0	-0.3	-0.7
Trunk fat percentage	0.2	0.7	1.1	-0.3	0.9	1.1
Age when periods started (menarche)	0.2	0.5	1.0	-0.6	0.3	-1.0
Tinnitus: Yes, but not now, but have in the past	0.2	0.3	0.3	-0.4	0.6	0.5
Stomach or abdominal pain in last month	0.2	0.2	0.3	0.6	0.4	-0.3
Medication: Ramipril	0.2	0.3	0.5	0.3	-0.6	0.7
Fluid intelligence score	0.2	0.5	1.0	0.2	1.0	0.7
Chronic bronchitis/emphysema (mother)	0.2	0.2	0.3	-0.6	0.6	-0.0
Wheeze or whistling in the chest in last year	0.2	0.4	0.5	0.4	0.7	-0.6
Pulse rate, automated reading	0.2	0.6	1.2	-0.7	-0.1	1.1
Average weekly champagne plus white wine intake	0.2	0.3	1.0	-0.2	1.0	0.1
Mother’s age at death	0.2	0.2	0.3	-0.2	-0.5	0.6
Medication: Paracetamol	0.2	0.2	0.4	-0.2	0.5	-0.7
Medication: Lisinopril	0.2	0.3	0.6	-0.8	0.1	-0.5
Illnesses of father: High blood pressure	0.2	0.3	0.6	-0.2	0.5	0.8
Myopia	0.2	0.4	0.8	0.1	-0.5	0.9
Pain experienced in last month	0.2	0.4	0.8	-0.6	-0.3	0.9
Supplements: Calcium	0.2	0.2	0.7	0.2	-0.8	-0.0
Alcohol drinker status: Previous	0.2	0.2	0.5	-0.2	0.2	-0.7
Impedance of whole body	0.2	1.2	2.9	-1.7	0.0	-0.8
Bipolar Disorder or Schizophrenia	0.1	0.2	0.5	-0.0	0.7	0.1
Blood Eosinophil Count	0.1	0.4	1.0	-0.5	0.2	-1.0
Blood Red Count	0.1	0.5	0.8	0.2	-0.8	0.9
Neuroticism	0.1	0.4	0.4	-0.5	0.6	0.7
Hair Pigment	0.1	1.6	3.8	-2.0	0.5	-0.8
Sensitivity / hurt feelings	0.1	0.2	0.3	-0.0	0.5	-0.5
Vitamin and mineral supplements	0.1	0.2	0.5	0.0	-0.0	0.7
Townsend deprivation index at recruitment	0.1	0.1	0.1	0.4	0.2	0.3
Multivitamins +/- minerals	0.1	0.2	0.2	0.3	0.5	-0.4
Impedance of leg (left)	0.1	0.5	0.7	-0.8	-0.8	-0.5
Heel bone mineral density (BMD) T-score, automated (right)	0.1	0.1	0.4	-0.2	0.1	-0.6
Arm fat percentage (right)	0.1	0.2	0.3	-0.5	0.5	0.3
Time employed in main current job	0.1	0.2	0.5	-0.1	0.7	-0.0
Father’s age at death	0.1	0.1	0.2	0.2	0.4	0.4
Falls in the last year	0.1	0.1	0.3	0.0	0.1	-0.5
Mouth/teeth dental problems: Dentures	0.1	0.1	0.3	-0.1	-0.4	0.5
Lung cancer (father)	0.1	0.1	0.2	0.1	-0.4	-0.3
Loud music exposure frequency	0.1	0.1	0.2	0.5	0.5	0.0
Medication: Paracetamol	0.1	0.2	0.3	-0.5	0.5	-0.2
Body fat percentage	0.1	0.3	0.5	-0.3	0.4	0.7
Mean time to correctly identify matches	0.1	0.2	0.3	-0.5	0.3	-0.5
Had major operations	0.1	0.1	0.1	-0.1	0.2	-0.4
Average weekly red wine intake	0.1	0.2	0.3	0.5	-0.5	0.1
Mood swings	0.1	0.2	0.4	-0.1	0.4	-0.6
Back pain experienced in last month	0.1	0.1	0.1	-0.1	-0.4	-0.4
Mineral and other dietary supplements	0.1	0.1	0.2	-0.3	0.4	0.2
Guilty feelings	0.1	0.2	0.3	-0.3	0.6	0.2
Supplements: Fish oil (including cod liver oil)	0.1	0.1	0.3	0.1	-0.5	-0.0
Average weekly beer plus cider intake	0.1	0.2	0.5	0.2	0.1	0.7
Age started oral contraceptive pill	0.1	0.1	0.3	-0.1	-0.1	-0.6
Alzheimer’s Disease (in father)	0.0	0.1	0.1	0.2	0.2	-0.2
Age at First Birth	0.0	0.1	0.1	0.2	-0.3	0.2
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0
Blood Platelet Count	0.0	0.5	0.8	0.5	-0.7	0.9
Lung FVC	0.0	0.2	0.4	0.7	-0.3	-0.2
Impedance of leg (right)	0.0	0.1	0.3	-0.5	-0.4	-0.2
Body mass index (BMI)	0.0	0.1	0.2	0.3	0.0	0.4
Leg fat percentage (right)	0.0	0.1	0.1	0.1	-0.3	0.3
Comparative body size at age 10	0.0	0.0	0.1	0.1	-0.0	-0.3
Suffer from ‘nerves’	0.0	0.1	0.1	-0.3	0.4	-0.0
Arm fat percentage (left)	0.0	0.1	0.3	-0.5	0.3	0.1
Hearing aid user	0.0	0.0	0.0	0.0	-0.1	-0.1
Leg fat percentage (left)	0.0	0.2	0.4	-0.3	-0.6	0.0
Ever depressed for a whole week	0.0	0.0	0.0	0.1	-0.2	-0.2

Hub : Genes

S1PR2

Models

Trait associations