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chr22:42,264,269-44,107,669

Best TWAS P=8.4e-11 · Best GWAS P=1.49e-12 conditioned to 1.13e-13

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	PACSIN2	0.07	0.05	lasso	3	0.04	7.7e-06	5.4	-5.7	1.2e-08	-0.07	0.08	0.92	FALSE
2	GTEx	Adipose Subcutaneous	ARFGAP3	0.07	0.07	enet	7	0.05	3.5e-05	-5.9	-6.0	1.5e-09	-0.06	0.06	0.94	FALSE
3	GTEx	Adipose Visceral Omentum	ARFGAP3	0.12	0.11	enet	18	0.09	1.4e-05	-5.9	-5.4	8.2e-08	-0.08	0.06	0.94	FALSE
4	GTEx	Artery Aorta	PACSIN2	0.10	0.07	lasso	1	0.04	1.7e-03	-5.1	-5.1	3.1e-07	-0.08	0.08	0.91	FALSE
5	GTEx	Artery Tibial	ARFGAP3	0.07	0.05	enet	11	0.04	2.2e-04	-5.9	-5.1	2.8e-07	-0.04	0.03	0.96	FALSE
6	GTEx	Breast Mammary Tissue	ARFGAP3	0.15	0.12	lasso	2	0.08	9.7e-05	-5.2	-5.2	2.3e-07	-0.08	0.21	0.78	FALSE
7	GTEx	Breast Mammary Tissue (Female)	ARFGAP3	0.18	0.11	lasso	6	0.05	1.2e-02	-5.1	-5.4	5.7e-08	-0.09	0.06	0.60	FALSE
8	GTEx	Colon Sigmoid	ARFGAP3	0.16	-0.01	lasso	5	0.00	3.9e-01	5.6	-6.4	1.3e-10	-0.10	0.08	0.52	FALSE
9	GTEx	Esophagus Mucosa	ARFGAP3	0.12	0.10	lasso	4	0.07	1.2e-05	-5.1	-5.1	2.9e-07	-0.08	0.35	0.64	FALSE
10	GTEx	Ovary	PACSIN2	0.25	0.16	lasso	7	0.11	1.2e-03	-5.9	-6.5	8.4e-11	-0.05	0.09	0.49	TRUE
11	GTEx	Prostate	RN7SKP80	0.19	0.22	lasso	4	0.23	2.1e-06	5.6	5.9	2.8e-09	0.04	0.07	0.61	FALSE
12	GTEx	Spleen	PACSIN2	0.37	0.11	lasso	13	0.11	9.0e-04	5.8	5.4	8.2e-08	0.08	0.05	0.82	FALSE
13	GTEx	Thyroid	ARFGAP3	0.20	0.21	lasso	5	0.22	1.1e-16	-5.1	-5.4	5.4e-08	-0.08	0.23	0.77	FALSE
14	GTEx	Whole Blood	ARFGAP3	0.07	0.10	enet	6	0.09	4.7e-09	-6.0	6.0	2.1e-09	0.06	0.03	0.97	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	A4GALT	0.03	0.01	enet	12	0.03	2.8e-06	-4.4	5.8	5.6e-09	0.06	0.03	0.46	FALSE
16	The Cancer Genome Atlas	Breast Invasive Carcinoma	ARFGAP3	0.05	0.05	lasso	5	0.06	6.5e-12	-5.9	-6.1	1.2e-09	-0.08	0.03	0.97	FALSE
17	The Cancer Genome Atlas	Colon Adenocarcinoma	A4GALT	0.10	0.00	blup	66	0.06	1.6e-04	-3.0	5.3	9.1e-08	0.00	0.02	0.74	TRUE
18	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	ARFGAP3	0.06	0.04	lasso	4	0.04	7.1e-06	-5.3	-5.3	1.1e-07	-0.07	0.10	0.89	FALSE
19	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ARFGAP3	0.12	0.09	lasso	5	0.05	8.7e-03	-6.0	-5.8	5.2e-09	-0.06	0.02	0.82	FALSE
20	The Cancer Genome Atlas	Thyroid Carcinoma	ARFGAP3	0.12	0.12	lasso	3	0.12	2.5e-11	-5.3	-5.5	4.4e-08	-0.07	0.16	0.84	FALSE