Best TWAS P=2.09e-14 · Best GWAS P=3.85e-18 conditioned to 1.44e-13
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | TTC27 | 0.17 | 0.00 | enet | 23 | 0.05 | 6.9e-03 | -3.1 | 7.7 | 2.1e-14 | -0.07 | 0.08 | 0.19 | TRUE |
| 2 | GTEx | Artery Aorta | YIPF4 | 0.12 | 0.00 | enet | 22 | 0.01 | 7.0e-02 | 4.6 | 5.7 | 1.3e-08 | -0.02 | 0.12 | 0.40 | FALSE |
| 3 | GTEx | Artery Tibial | LTBP1 | 0.10 | 0.04 | enet | 12 | 0.03 | 1.5e-03 | -5.0 | 5.5 | 3.8e-08 | -0.11 | 0.81 | 0.05 | FALSE |
| 4 | GTEx | Cells EBV-transformed lymphocytes | RP11-563N4.1 | 0.16 | 0.00 | enet | 17 | 0.01 | 1.4e-01 | -4.3 | 5.4 | 5.6e-08 | 0.02 | 0.06 | 0.34 | FALSE |
| 5 | GTEx | Cells Transformed fibroblasts | LTBP1 | 0.48 | 0.51 | enet | 58 | 0.51 | 2.4e-43 | -5.3 | 5.6 | 2.6e-08 | -0.07 | 1.00 | 0.00 | TRUE |
| 6 | GTEx | Thyroid | SPAST | 0.08 | 0.02 | lasso | 3 | 0.01 | 1.0e-01 | -6.6 | -6.6 | 3.5e-11 | 0.04 | 0.08 | 0.60 | FALSE |
| 7 | METSIM | Adipose | DPY30 | 0.02 | 0.00 | bslmm | 325 | 0.00 | 2.8e-01 | 3.5 | 5.3 | 1.4e-07 | -0.01 | 0.06 | 0.36 | TRUE |
| 8 | YFS | Blood | BIRC6 | 0.02 | 0.00 | blup | 458 | 0.00 | 3.0e-02 | -7.7 | 5.8 | 7.7e-09 | -0.04 | 0.01 | 0.91 | FALSE |
| 9 | The Cancer Genome Atlas | Liver Hepatocellular Carcinoma | LTBP1 | 0.21 | 0.08 | lasso | 5 | 0.08 | 1.8e-04 | 3.0 | -5.2 | 1.8e-07 | 0.07 | 0.13 | 0.22 | TRUE |