[Hub]/) : Traits : Sitting height :

chr2:26,592,429-28,607,344

Best TWAS P=4.74e-25 · Best GWAS P=5.04e-24 conditioned to 1

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex GTF3C2 0.06 0.09 lasso 8 0.08 7.2e-10 5.3 -6.8 1.3e-11 0.72 0.28 0.72 FALSE
2 CommonMind Brain Pre-frontal Cortex IFT172 0.06 0.09 enet 16 0.09 3.9e-11 5.2 6.9 7.0e-12 -0.75 0.48 0.52 FALSE
3 GTEx Adipose Subcutaneous AC074117.10 0.06 0.04 lasso 5 0.02 4.8e-03 6.0 -6.2 7.7e-10 0.65 0.45 0.27 FALSE
4 GTEx Adipose Visceral Omentum NRBP1 0.05 0.05 lasso 4 0.04 2.5e-03 5.3 -5.4 7.3e-08 0.61 0.34 0.07 FALSE
5 GTEx Adipose Visceral Omentum PPM1G 0.06 0.01 lasso 5 0.01 1.1e-01 5.3 -5.7 1.1e-08 0.64 0.11 0.28 FALSE
6 GTEx Adipose Visceral Omentum KRTCAP3 0.10 0.07 lasso 4 0.06 5.2e-04 5.3 5.3 9.5e-08 -0.61 0.68 0.10 FALSE
7 GTEx Adipose Visceral Omentum AC074117.10 0.14 0.09 lasso 3 0.08 5.0e-05 5.6 -5.6 2.6e-08 0.60 0.85 0.08 FALSE
8 GTEx Adrenal Gland KRTCAP3 0.11 0.16 lasso 4 0.15 4.9e-06 5.3 5.2 2.0e-07 -0.60 0.54 0.38 FALSE
9 GTEx Artery Aorta AC074117.10 0.06 0.04 lasso 3 0.03 6.8e-03 5.6 -5.5 3.2e-08 0.58 0.24 0.14 FALSE
10 GTEx Artery Tibial PPM1G 0.06 0.02 lasso 4 0.03 2.3e-03 5.3 -6.2 7.8e-10 0.66 0.29 0.12 FALSE
11 GTEx Artery Tibial AC074117.10 0.13 0.14 lasso 5 0.13 1.1e-10 5.6 -5.9 4.0e-09 0.62 0.99 0.00 FALSE
12 GTEx Brain Cerebellum AC074117.10 0.13 0.08 enet 6 0.07 4.4e-03 5.5 5.5 3.2e-08 -0.60 0.09 0.48 FALSE
13 GTEx Brain Cortex KRTCAP3 0.19 0.10 lasso 2 0.12 3.7e-04 4.7 5.2 2.6e-07 -0.54 0.24 0.35 FALSE
14 GTEx Cells EBV-transformed lymphocytes NRBP1 0.11 0.13 enet 13 0.15 1.2e-05 5.3 -6.0 2.3e-09 0.62 0.57 0.10 FALSE
15 GTEx Cells Transformed fibroblasts NRBP1 0.09 0.08 lasso 3 0.08 7.8e-07 5.6 -5.3 1.3e-07 0.61 0.95 0.04 FALSE
16 GTEx Cells Transformed fibroblasts AC074117.10 0.21 0.19 enet 23 0.18 1.6e-13 6.0 -5.7 1.3e-08 0.66 0.87 0.13 FALSE
17 GTEx Colon Sigmoid AC074117.10 0.13 0.18 lasso 3 0.14 1.1e-05 5.6 -5.6 2.2e-08 0.60 0.85 0.08 FALSE
18 GTEx Colon Transverse NRBP1 0.08 0.03 enet 14 0.00 2.0e-01 5.6 -5.5 3.7e-08 0.59 0.16 0.14 FALSE
19 GTEx Esophagus Gastroesophageal Junction NRBP1 0.11 0.01 enet 23 0.02 7.7e-02 2.9 -5.2 2.2e-07 0.53 0.12 0.24 FALSE
20 GTEx Esophagus Gastroesophageal Junction AC074117.10 0.12 0.13 enet 9 0.09 4.9e-04 5.5 -5.4 5.9e-08 0.64 0.43 0.30 FALSE
21 GTEx Esophagus Mucosa AC074117.10 0.12 0.14 lasso 8 0.14 2.1e-09 6.0 -7.0 1.9e-12 0.74 0.94 0.06 FALSE
22 GTEx Esophagus Muscularis NRBP1 0.07 0.04 lasso 6 0.04 1.3e-03 6.0 -8.0 1.2e-15 0.82 0.01 0.97 FALSE
23 GTEx Esophagus Muscularis AC074117.10 0.17 0.14 enet 5 0.09 6.6e-06 6.0 -6.2 5.5e-10 0.65 0.73 0.26 FALSE
24 GTEx Lung NRBP1 0.05 0.05 enet 9 0.05 1.7e-04 5.3 -5.2 1.9e-07 0.61 0.75 0.16 FALSE
25 GTEx Lung AC074117.10 0.07 0.06 lasso 6 0.05 6.6e-05 5.3 -5.5 4.6e-08 0.63 0.75 0.25 FALSE
26 GTEx Muscle Skeletal SNX17 0.18 0.24 lasso 6 0.26 6.2e-26 5.5 -5.5 2.8e-08 0.61 1.00 0.00 FALSE
27 GTEx Muscle Skeletal KRTCAP3 0.08 0.06 lasso 4 0.04 3.1e-05 5.3 5.3 9.3e-08 -0.59 1.00 0.00 FALSE
28 GTEx Ovary AC074117.10 0.16 0.04 enet 9 0.05 2.0e-02 5.3 -7.2 8.3e-13 0.77 0.04 0.80 FALSE
29 GTEx Pituitary AC074117.10 0.23 0.23 lasso 8 0.29 5.6e-08 4.4 -5.7 1.4e-08 0.66 0.34 0.57 FALSE
30 GTEx Skin Sun Exposed Lower leg NRBP1 0.10 0.08 lasso 6 0.08 3.6e-07 5.5 -5.3 1.5e-07 0.58 1.00 0.00 FALSE
31 GTEx Skin Sun Exposed Lower leg SLC4A1AP 0.04 0.01 lasso 3 0.02 1.7e-02 5.3 5.6 2.3e-08 -0.60 0.21 0.11 FALSE
32 GTEx Testis NRBP1 0.16 0.09 lasso 3 0.06 1.8e-03 6.0 -7.4 1.6e-13 0.80 0.03 0.96 FALSE
33 GTEx Testis AC074117.10 0.14 0.08 lasso 6 0.12 4.5e-06 5.3 -8.0 1.4e-15 0.85 0.05 0.94 FALSE
34 GTEx Testis RP11-195B17.1 0.13 0.00 lasso 4 0.02 4.5e-02 5.3 -5.3 1.3e-07 0.58 0.04 0.15 FALSE
35 GTEx Thyroid FNDC4 0.24 0.10 enet 23 0.16 2.2e-12 4.8 7.8 4.7e-15 -0.69 0.67 0.33 FALSE
36 GTEx Thyroid PPM1G 0.06 0.06 lasso 3 0.06 2.2e-05 5.3 -5.3 1.2e-07 0.60 0.92 0.01 FALSE
37 GTEx Thyroid AC074117.10 0.17 0.14 lasso 4 0.15 2.7e-11 5.5 -5.6 2.2e-08 0.61 1.00 0.00 FALSE
38 GTEx Vagina AC074117.10 0.14 0.04 enet 13 0.06 1.4e-02 4.7 -6.5 6.7e-11 0.72 0.08 0.57 FALSE
39 METSIM Adipose NRBP1 0.06 0.09 lasso 3 0.08 1.6e-12 6.0 -6.3 3.7e-10 0.67 1.00 0.00 FALSE
40 METSIM Adipose SLC5A6 0.03 0.02 bslmm 298 0.01 3.9e-03 3.6 -5.1 3.0e-07 0.43 0.25 0.04 FALSE
41 ROSMAP Brain Pre-frontal Cortex SNX17 0.27 0.35 lasso 10 0.34 7.9e-46 5.3 5.3 8.7e-08 -0.60 1.00 0.00 FALSE
42 ROSMAP Brain Pre-frontal Cortex IFT172 0.07 0.02 blup 287 0.03 5.8e-05 5.6 6.3 2.5e-10 -0.63 0.43 0.49 FALSE
43 ROSMAP Brain Pre-frontal Cortex FTH1P3 0.04 0.01 bslmm 280 0.02 2.8e-03 6.0 -5.9 3.4e-09 0.65 0.04 0.70 FALSE
44 YFS Blood KRTCAP3 0.12 0.18 bslmm 286 0.18 1.0e-55 5.2 5.1 2.7e-07 -0.59 1.00 0.00 FALSE
45 YFS Blood NRBP1 0.01 0.01 lasso 6 0.01 9.1e-06 5.3 -5.9 3.3e-09 0.61 0.99 0.00 FALSE
46 The Cancer Genome Atlas Bladder Urothelial Carcinoma NRBP1 0.05 0.06 lasso 2 0.05 6.0e-05 5.4 -5.3 8.7e-08 0.60 0.82 0.02 FALSE
47 The Cancer Genome Atlas Bladder Urothelial Carcinoma PPM1G 0.03 0.02 blup 31 0.02 8.8e-03 5.5 -6.0 1.5e-09 0.66 0.03 0.51 FALSE
48 The Cancer Genome Atlas Breast Invasive Carcinoma GPN1 0.06 0.02 lasso 6 0.02 7.2e-05 -7.2 -6.5 1.1e-10 0.54 0.00 0.98 FALSE
49 The Cancer Genome Atlas Breast Invasive Carcinoma SNX17 0.08 0.01 blup 25 0.02 6.6e-05 1.9 5.2 2.2e-07 -0.55 0.02 0.34 FALSE
50 The Cancer Genome Atlas Colon Adenocarcinoma NRBP1 0.03 0.04 lasso 1 0.03 5.2e-03 5.3 -5.3 1.1e-07 0.59 0.04 0.11 FALSE
51 The Cancer Genome Atlas Glioblastoma Multiforme NRBP1 0.15 0.10 lasso 2 0.10 5.8e-04 6.0 -6.0 1.4e-09 0.67 0.02 0.09 FALSE
52 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma IFT172 0.02 0.01 blup 43 0.02 2.7e-03 4.8 -5.2 2.0e-07 0.60 0.10 0.10 FALSE
53 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma KRTCAP3 0.02 0.01 blup 28 0.01 2.9e-02 5.2 5.2 2.4e-07 -0.57 0.08 0.05 FALSE
54 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma NRBP1 0.06 0.07 lasso 2 0.07 1.1e-08 5.2 -5.2 1.8e-07 0.60 1.00 0.00 FALSE
55 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SNX17 0.02 0.01 blup 26 0.01 2.1e-02 5.4 5.5 4.3e-08 -0.62 0.13 0.18 FALSE
56 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma SUPT7L 0.05 0.02 blup 28 0.04 5.2e-05 4.7 6.2 4.4e-10 -0.40 0.19 0.14 FALSE
57 The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma FNDC4 0.13 0.06 lasso 2 0.05 1.1e-03 -10.1 10.3 4.7e-25 -0.99 0.00 0.96 TRUE
58 The Cancer Genome Atlas Lung Adenocarcinoma NRBP1 0.03 0.05 blup 30 0.05 3.7e-06 5.2 -5.2 2.4e-07 0.59 0.97 0.01 FALSE
59 The Cancer Genome Atlas Prostate Adenocarcinoma NRBP1 0.03 0.03 blup 30 0.03 2.2e-04 4.7 -5.9 4.1e-09 0.64 0.67 0.09 FALSE
60 The Cancer Genome Atlas Prostate Adenocarcinoma PPM1G 0.03 0.02 blup 32 0.02 2.4e-03 5.5 -5.5 3.5e-08 0.61 0.16 0.05 FALSE
61 The Cancer Genome Atlas Thyroid Carcinoma FNDC4 0.24 0.09 enet 9 0.17 1.9e-16 5.0 8.0 1.2e-15 -0.70 0.41 0.59 FALSE
62 The Cancer Genome Atlas Thyroid Carcinoma GCKR 0.18 0.08 enet 5 0.13 1.7e-12 4.8 7.2 6.8e-13 -0.64 0.91 0.09 FALSE
63 The Cancer Genome Atlas Thyroid Carcinoma IFT172 0.08 0.01 blup 43 0.02 6.1e-03 6.1 6.1 1.0e-09 -0.54 0.02 0.27 FALSE
64 The Cancer Genome Atlas Thyroid Carcinoma NRBP1 0.03 0.01 blup 30 0.02 5.3e-03 6.0 -5.6 2.2e-08 0.62 0.32 0.05 FALSE