Hub : Genes

RP11-563N4.1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells EBV-transformed lymphocytes	0.1550	0.0800	0.00340	-0.003	NA	0.011	NA	0.001	4.1e-01	NA	1.4e-01	NA	2.9e-01
2	GTEx	Cells Transformed fibroblasts	0.0590	0.0320	0.00088	0.050	NA	0.039	NA	0.051	1.2e-04	NA	6.2e-04	NA	1.1e-04
3	GTEx	Esophagus Gastroesophageal Junction	0.3460	0.1040	0.00077	-0.008	NA	0.067	NA	0.024	8.6e-01	NA	2.0e-03	NA	4.7e-02
4	GTEx	Esophagus Muscularis	0.0480	0.0280	0.00410	0.019	NA	0.005	NA	0.015	2.5e-02	NA	1.5e-01	NA	4.2e-02
5	GTEx	Muscle Skeletal	0.0499	0.0305	0.00560	0.049	NA	0.025	NA	0.030	1.3e-05	NA	1.6e-03	NA	5.6e-04
6	GTEx	Nerve Tibial	0.1129	0.0502	0.00072	0.021	NA	0.016	NA	0.013	1.1e-02	NA	2.6e-02	NA	4.0e-02
7	GTEx	Spleen	0.2890	0.1370	0.00160	0.100	NA	0.178	NA	0.207	1.6e-03	NA	2.6e-05	NA	5.0e-06
8	GTEx	Testis	0.0790	0.0470	0.00260	0.060	NA	0.037	NA	0.024	1.2e-03	NA	9.6e-03	NA	3.1e-02
9	METSIM	Adipose	0.0409	0.0291	0.00049	0.016	0.024	0.040	0.029	0.021	1.5e-03	0.00012	1.2e-06	3.2e-05	3.8e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9
Bipolar Disorder (2018)	1.5	2.4	6.3	-2.5	-1.9	-1.6	-0.3	-2.2	0.8	-1.6	-1.0	0.0
Bipolar Disorder or Schizophrenia	1.2	2.9	5.9	-2.4	-2.1	-1.8	-0.2	-2.2	-0.9	-2.2	-1.2	-0.6
Depressed Affect (Nagel 2018)	0.5	1.1	4.2	-2.0	-1.2	1.0	-0.2	-0.3	-1.7	0.0	-0.3	-0.4
Depression (Nagel 2018)	0.5	0.8	3.3	-1.8	-0.7	0.7	0.2	0.1	-1.6	-0.2	-0.1	0.1
Intelligence (Savage-Jansen 2018)	4.2	12.8	21.5	4.6	3.9	1.3	4.4	3.6	2.1	3.6	3.7	3.8
Neuroticism (Nagel 2018)	0.4	1.0	3.5	-1.9	-0.6	0.7	0.5	-0.1	-1.8	0.8	-0.0	-0.5
Schizophrenia (2018)	0.8	1.6	3.5	-1.3	-1.4	-1.0	0.1	-1.5	-1.9	-1.7	-0.7	-0.6
Schizophrenia vs Biploar Disorder	0.9	1.2	3.8	1.8	1.1	0.1	1.2	0.7	-1.9	0.7	0.2	0.3
Worry (Nagel 2018)	0.3	0.6	2.2	-1.4	-0.2	0.4	0.2	0.1	-1.5	0.2	-0.3	-0.7
Alzheimer’s Disease (in mother)	0.4	0.5	1.5	-0.7	-0.3	-0.2	-0.4	-0.1	-1.2	-1.2	-0.7	-0.1
Alzheimer’s Disease (in father)	1.2	1.3	2.8	1.4	1.6	-0.3	0.9	1.3	-0.0	1.3	-0.4	1.7
Alzheimer’s Disease (including proxy)	0.3	0.4	1.5	0.3	0.8	-0.4	0.7	0.5	-1.2	-0.0	-0.3	0.9
Crohns Disease (2017)	0.4	0.8	3.1	0.7	0.7	-1.8	1.1	-0.5	0.0	0.4	1.2	0.5
Irritable Bowel Disease (IBD)	0.9	2.1	5.8	1.5	1.4	-1.4	1.9	0.0	0.5	1.2	2.4	1.1
Ulcerative Colitis (UC)	1.0	1.8	5.5	1.6	1.1	-0.7	1.7	0.6	0.7	1.3	2.3	1.0
Major Depression (MDD)	1.7	2.0	5.8	-1.0	-1.0	-0.8	-1.8	0.0	-2.4	-1.6	-1.4	-1.4
Reaction Time	2.1	3.9	9.4	-3.1	-2.8	0.8	0.0	-3.0	-1.8	-2.2	-0.8	0.3
Verbal and Numeric Reasoning (VNR)	2.5	6.1	14.3	3.8	3.2	0.7	3.1	2.7	0.1	1.8	2.2	2.1
Breast Cancer	0.5	1.2	3.6	1.5	1.0	1.6	0.3	0.9	1.9	0.5	0.3	-0.1
Ovarian Cancer	0.3	0.4	1.1	0.8	0.5	0.4	0.8	0.3	0.9	0.1	0.3	1.1
Prostate Cancer	0.5	0.7	2.2	-0.7	-0.4	0.9	0.2	0.4	1.5	0.3	1.3	0.4
Age at First Birth	1.4	2.1	5.1	2.3	1.9	-0.0	0.0	1.6	1.2	1.4	1.8	0.6
Bipolar Disorder (2011)	1.5	1.5	5.3	-2.0	0.0	-1.1	0.5	-1.0	1.2	0.0	-0.4	2.3
Body Mass Index (BMI) (2010)	1.4	1.9	5.1	0.6	1.4	2.3	2.1	0.6	-0.7	1.2	1.3	1.1
Coronary Artery Disease (CAD)	0.2	0.3	1.3	0.2	0.4	0.2	1.1	0.3	-0.3	0.2	0.7	0.6
Crohns Disease (2012)	0.4	0.6	1.6	0.1	0.0	-0.8	1.2	-0.8	0.8	0.5	1.2	0.5
Mean Putamen Volume	2.3	2.6	5.6	2.4	2.1	0.9	2.0	1.3	1.2	1.5	1.8	-0.1
Fasting Glucose	0.5	0.6	2.4	0.3	-0.0	0.3	1.0	-0.4	-0.9	0.6	0.9	1.6
HbA1C	0.3	0.4	0.7	-0.7	-0.1	0.6	-0.4	-0.1	-0.8	-0.7	-0.7	-0.8
HDL Cholesterol	0.6	1.1	2.6	1.5	1.6	-1.6	0.7	1.2	0.1	0.2	-0.6	-0.3
LDL Cholesterol	0.8	1.3	5.9	-0.9	-0.4	1.7	0.4	-0.7	-2.4	-0.3	-1.0	-0.2
Lupus	0.2	0.2	0.5	-0.6	-0.5	-0.2	0.7	-0.4	-0.5	0.0	0.3	0.6
Neuroticism (2016)	0.7	1.1	3.1	-1.1	-0.7	1.8	1.2	-1.2	-0.3	-0.2	0.8	1.1
Primary Biliary Cirrhosis	1.7	2.4	7.8	0.8	2.0	0.2	2.6	1.2	0.4	1.0	0.5	2.8
Rheumatoid Arthritis	0.3	0.4	1.4	0.2	0.2	0.6	-1.2	-0.3	0.0	-0.8	-0.8	-0.5
Schizophrenia (2014)	0.8	1.8	3.8	-1.5	-1.9	-1.1	0.2	-1.8	-1.6	-1.6	-0.9	-0.1
Triglycerides	0.5	0.8	2.3	-1.2	-1.5	1.0	-0.0	-1.4	0.2	-0.2	0.2	0.8
Type 2 Diabetes (T2D) (2012)	0.6	0.7	2.3	-0.9	-0.9	0.7	0.1	-1.5	-0.6	-1.3	-0.3	0.0
Ulcerative Colitis	0.9	1.3	5.3	0.7	0.3	-1.4	1.4	-0.9	0.9	0.4	2.3	0.5
Blood Eosinophil Count	0.1	0.7	2.2	0.4	-0.4	-0.4	-1.5	-0.4	1.2	-1.0	-0.6	-0.8
Blood Platelet Count	1.0	11.8	24.9	-4.0	-3.7	-0.5	-3.1	-2.3	-2.6	-5.0	-4.2	-3.5
Blood Red Count	0.1	0.8	3.4	-0.3	-0.6	0.7	0.1	0.0	1.8	0.2	1.6	0.1
Blood White Count	0.9	6.3	16.6	-2.7	-2.7	-0.9	-2.6	-1.3	-1.3	-4.1	-3.2	-2.1
Heel T-Score	0.3	2.5	6.1	-1.8	-0.6	2.5	1.7	0.3	-0.5	1.5	2.2	1.6
BMI	0.2	1.1	7.8	-0.6	-0.3	1.1	-0.1	-0.0	-2.8	-0.3	-0.6	0.5
Height	0.6	11.3	39.8	6.3	5.0	-2.0	1.1	3.7	2.9	2.9	1.2	-0.5
Waist Hip Ratio (WHR)	1.1	5.0	17.1	-4.1	-3.2	0.2	-2.5	-1.5	1.0	-2.5	-1.0	-0.8
Systolic Blood Pressure	0.6	2.8	7.9	-2.6	-2.8	-0.8	-0.8	-1.8	1.1	-1.8	-0.5	-0.8
Smoking Status	3.9	9.3	20.6	-4.5	-3.9	0.3	-3.7	-2.3	-2.2	-3.2	-2.9	-2.1
Allergy or Eczema	0.4	1.0	3.7	0.2	0.3	1.7	0.9	0.7	-0.5	0.4	1.0	1.9
Cardiovascular Disease	1.4	4.7	12.4	-3.4	-3.5	-0.5	-1.8	-2.6	-0.4	-2.4	-0.9	-0.9
Hypothyroidism (self reported)	1.2	2.8	4.6	-1.2	-1.7	-1.4	-2.0	-2.1	-0.8	-1.8	-1.4	-2.1
Respiratory disease	0.6	1.4	3.3	-1.8	-1.6	-0.1	-1.6	-0.5	0.7	-1.2	-1.0	-0.9
Type 2 Diabetes (T2D) (2018)	0.8	1.6	4.3	-2.1	-1.4	0.2	-0.5	-1.3	-0.1	-1.8	-0.8	-1.4
Lung FEV1/FVC ratio	0.2	1.0	3.8	-0.2	-0.4	0.5	-1.2	0.0	-1.6	-2.0	-0.9	0.2
Lung FVC	0.1	0.4	1.3	0.7	-0.1	0.5	0.6	0.3	-0.3	1.1	0.9	0.6
Neuroticism	0.6	1.4	5.1	-1.9	-0.7	1.0	-0.7	0.5	-2.3	0.3	-0.5	-1.1
Chronotype (morning person)	0.9	2.2	8.9	3.0	2.0	-0.3	0.0	1.1	-0.8	0.0	-1.2	-1.8
Hair Pigment	0.0	1.2	2.3	-0.0	-0.7	-1.3	-1.5	-0.8	0.3	-1.0	-1.5	-1.5
Tanning	0.1	0.9	2.4	-1.6	0.1	1.4	1.2	0.4	-0.7	-0.6	-0.6	1.0
Hand grip strength (left)	1.4	3.6	5.5	2.3	2.3	0.9	2.3	1.6	1.9	2.4	1.4	1.6
Number of treatments/medications taken	1.6	2.9	6.7	-2.6	-2.6	-0.4	-1.8	-1.3	-1.2	-1.8	-1.3	-1.1
Average weekly spirits intake	0.6	0.7	2.0	0.6	1.1	0.6	0.4	1.4	1.4	0.4	-0.1	0.2
Sensitivity / hurt feelings	0.4	0.6	2.2	-0.4	0.2	-1.5	0.5	0.3	0.3	1.5	0.5	0.2
Frequency of depressed mood in last 2 weeks	2.0	2.9	6.5	-2.4	-2.1	0.8	-1.2	-1.4	-2.5	-1.4	-0.7	-1.6
Hearing difficulty/problems: Yes	0.9	1.3	4.9	-0.1	0.4	1.2	1.0	1.2	0.7	1.2	1.1	2.2
Relative age of first facial hair	3.3	6.9	18.0	2.7	2.3	0.5	2.3	1.7	4.1	4.2	2.4	0.5
Other serious medical condition/disability diagnosed by doctor	1.2	1.6	4.9	-1.3	-0.9	-2.2	-1.3	-0.7	-0.7	-1.2	-1.3	0.8
Ever used hormone-replacement therapy (HRT)	4.1	5.2	12.0	-3.5	-2.9	-0.2	-1.9	-1.8	-1.8	-3.0	-2.5	-0.9
Ever had hysterectomy (womb removed)	0.6	0.7	2.1	-0.0	0.2	1.4	1.2	-0.2	-0.7	0.1	1.4	0.1
Systolic blood pressure, automated reading	0.5	1.4	4.4	-2.1	-2.0	-0.5	-1.1	-1.0	0.6	-1.2	-0.4	0.4
Eye problems/disorders: Diabetes related eye disease	0.5	0.5	1.7	-0.8	-0.6	0.2	-0.3	-0.1	-1.3	-0.4	-0.9	-0.9
Angina	1.1	1.4	3.5	-1.8	-1.9	1.8	0.6	-1.0	0.7	-0.5	-0.2	0.6
Medication for hormone replacement therapy	4.5	5.1	10.2	-2.5	-2.4	-0.8	-2.5	-2.0	-1.7	-2.9	-3.2	-1.2
Vitamin and mineral supplements	1.2	1.7	4.7	1.2	1.2	-0.3	2.2	0.6	1.3	1.4	1.1	1.5
Supplements: Zinc	0.3	0.4	1.0	-1.0	-0.6	0.4	-0.3	-0.1	-0.7	-0.8	0.0	-0.6
Medication: Co-codamol	0.3	0.3	0.8	-0.9	-0.6	-0.2	-0.2	-0.5	0.2	-0.9	-0.7	0.3
Medication: Metformin	0.3	0.4	1.7	-0.7	0.4	1.3	0.3	0.8	-0.7	0.5	-0.1	-0.3
Diabetes (father)	1.1	1.3	3.2	-0.0	0.3	1.8	1.4	0.7	-1.5	0.6	1.7	0.7
Diabetes (mother)	0.8	1.0	2.2	-0.1	-0.3	-1.5	-1.2	0.1	0.3	-0.7	-1.5	-1.5
Severe depression (siblings)	1.9	2.2	5.2	-2.3	-1.1	-1.6	-0.9	-0.9	-1.2	-1.5	-1.5	-1.7
Pack years adult smoking proportion	1.8	2.7	5.9	-2.4	-2.1	1.5	-1.9	-1.5	-1.3	-1.3	-1.1	-1.1
Impedance of leg (right)	0.1	0.5	1.5	-0.8	-0.8	-0.9	-0.7	-0.3	-0.4	-0.6	-1.2	-0.1
Leg fat-free mass (left)	0.3	1.5	3.8	1.9	1.9	-0.0	0.4	1.4	0.6	1.6	1.1	-0.1
Trunk fat percentage	0.6	2.5	9.1	-2.3	-1.3	1.4	-0.8	-0.7	-3.0	-1.4	-0.8	0.8
Hand grip strength (right)	1.1	3.1	6.6	2.6	2.4	0.3	2.0	1.4	1.8	2.0	0.9	1.3
Townsend deprivation index at recruitment	4.6	6.5	13.7	-3.6	-3.7	0.0	-2.8	-2.9	-2.0	-2.6	-1.4	-1.6
Current tobacco smoking	5.5	9.0	18.5	-4.3	-4.0	0.9	-3.5	-2.4	-2.3	-3.0	-3.2	-2.0
Average weekly fortified wine intake	0.3	0.3	1.8	0.3	0.4	0.1	-0.1	-0.4	-0.5	0.1	1.4	0.3
Maternal smoking around birth	4.2	6.1	11.2	-3.0	-2.9	0.2	-2.9	-1.7	-1.8	-2.2	-2.7	-3.4
Fed-up feelings	2.8	5.1	11.7	-3.4	-3.1	0.2	-2.6	-2.0	-2.5	-1.9	-1.2	-1.3
Frequency of unenthusiasm / disinterest in last 2 weeks	2.2	3.0	10.2	-3.2	-1.9	0.7	-1.4	-0.6	-2.5	-1.2	-1.1	-1.0
Relative age voice broke	1.3	2.0	6.4	1.5	0.8	0.2	1.5	0.8	1.8	2.5	1.8	-0.5
Taking other prescription medications	0.7	1.2	2.0	-1.4	-1.3	0.3	-1.4	-0.7	-1.2	-1.3	-1.0	-0.5
Age when periods started (menarche)	0.2	0.6	1.6	1.3	0.9	-0.7	0.2	0.7	-0.4	0.6	-1.0	-0.6
Bilateral oophorectomy (both ovaries removed)	0.3	0.3	1.7	-0.5	0.4	0.6	-0.1	0.5	-1.3	-0.1	-0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.1	0.3	2.2	0.1	-0.3	0.5	0.1	-0.1	0.1	0.0	1.5	0.7
Tinnitus: Yes, but not now, but have in the past	1.7	1.9	4.3	-1.3	-1.1	-1.1	-1.9	-1.0	-1.2	-1.4	-2.1	-0.7
Qualifications: CSEs or equivalent	0.6	0.8	2.8	-0.4	-0.1	-0.2	-1.2	1.2	-0.7	0.3	-1.7	-1.0
Serious illness, injury or assault to yourself	0.6	0.7	5.0	0.7	0.6	-2.2	0.2	0.7	0.5	0.1	-0.3	0.0
High blood pressure	0.3	0.9	3.6	-1.9	-1.5	-0.7	-0.8	-0.6	0.3	-0.8	0.2	0.6
Hayfever, allergic rhinitis or eczema	0.5	1.2	2.9	0.6	0.9	1.7	0.5	1.3	0.1	0.8	1.1	1.7
Multivitamins +/- minerals	2.0	2.5	4.5	-1.9	-1.6	0.5	-1.7	-1.3	-1.9	-2.1	-1.0	-1.6
Stomach or abdominal pain in last month	0.5	0.6	2.6	-0.4	-0.6	-0.6	-0.6	-0.2	-1.6	-0.6	-1.0	-0.3
Supplements: Glucosamine	1.4	1.8	4.6	-1.0	-2.1	0.7	-0.6	-1.5	-1.4	-1.5	-1.5	-0.8
Diverticular disease/diverticulitis (self-reported)	1.3	1.6	4.9	0.2	0.6	1.1	1.7	1.2	0.0	1.6	2.2	0.7
Medication: Atenolol	0.6	0.7	1.5	0.4	0.1	-1.0	1.1	-0.2	1.2	0.7	1.2	0.8
Medication: Levothyroxine sodium	0.9	1.5	4.5	-0.8	-1.1	-2.1	-1.0	-1.5	0.3	-1.1	-0.6	-1.5
Sitting height	1.3	9.1	29.5	5.4	3.8	-1.4	1.4	2.4	2.8	3.3	2.9	-0.7
Chronic bronchitis/emphysema (father)	1.4	1.6	4.3	-2.0	-1.2	-0.1	-1.0	-0.9	-2.1	-0.8	-1.5	-0.4
High blood pressure (mother)	0.9	1.3	3.9	-1.9	-2.0	-0.6	-1.0	-0.8	1.0	0.1	1.2	-0.2
Body mass index (BMI)	0.4	1.7	6.2	-1.7	-1.1	1.6	-1.0	-0.6	-2.5	-0.7	-0.9	0.3
Impedance of leg (left)	0.3	1.6	3.6	-1.9	-1.7	-0.4	-1.2	-1.0	-1.0	-1.4	-1.5	-0.4
Leg predicted mass (left)	0.3	1.6	3.9	2.0	1.9	-0.0	0.5	1.4	0.7	1.6	1.2	0.0
Trunk fat mass	0.3	1.4	7.2	-1.3	-0.6	1.3	-0.7	-0.3	-2.7	-0.8	-0.6	0.6
Waist circumference	0.3	1.2	3.4	-1.8	-1.0	1.1	-0.9	-0.3	-1.8	-0.7	-0.5	0.8
Number of incorrect matches in round	0.6	1.0	3.2	-1.8	-1.6	-0.6	-1.1	-0.7	-0.9	-0.2	-0.4	-0.7
Past tobacco smoking	0.8	1.5	4.2	2.0	1.4	-0.3	1.0	1.2	1.5	1.0	1.0	0.5
Alcohol usually taken with meals	0.4	0.7	2.7	0.5	0.2	-0.7	0.8	-0.8	1.6	0.3	0.4	-1.3
Nervous feelings	0.4	0.7	2.1	1.0	1.4	-0.1	0.6	1.2	0.0	0.9	0.1	1.0
Frequency of tenseness / restlessness in last 2 weeks	1.3	2.0	7.3	-2.7	-1.9	1.1	-1.1	-0.5	-1.9	-0.7	-0.4	-0.6
Hearing difficulty/problems with background noise	1.2	1.9	5.7	0.7	1.2	0.5	1.3	1.9	0.9	1.5	0.6	2.4
Hair/balding pattern: Pattern 2	3.3	4.2	8.2	-2.2	-2.1	-0.9	-2.3	-2.2	-0.2	-2.9	-2.1	-2.2
Had menopause	0.4	0.5	2.0	-1.0	-0.7	0.2	-0.4	0.2	-0.3	-1.4	-0.4	1.0
Had other major operations	0.2	0.2	0.8	-0.9	-0.2	0.1	-0.0	-0.3	0.3	0.1	-0.3	0.8
Forced vital capacity (FVC)	0.3	1.0	4.1	2.0	1.3	0.1	0.5	0.8	0.6	1.2	0.6	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.1	0.2	-0.1	1.1	-0.0	0.7	-0.8	-0.1	0.8	0.8
Ever unenthusiastic/disinterested for a whole week	1.1	1.4	6.0	-2.4	-1.5	1.4	-0.3	-0.2	-1.2	-0.4	-0.1	-0.7
Qualifications: None of the above	1.6	3.4	7.0	-2.6	-2.6	1.2	-1.6	-1.8	-2.0	-2.0	-1.4	0.5
Financial difficulties in last 2 years	2.3	3.1	5.4	-1.9	-2.0	-0.2	-2.3	-1.7	-1.1	-1.8	-1.5	-2.3
Mouth/teeth dental problems	2.6	3.9	11.2	3.3	2.0	-1.3	2.1	0.6	2.4	1.8	2.2	0.4
Heart attack	0.8	1.1	3.5	-1.5	-1.9	0.4	0.3	-1.4	0.9	-0.6	0.4	0.6
Allergy	0.2	0.4	2.2	0.4	-0.2	-1.5	0.1	-0.4	-0.0	-0.2	-0.1	-1.1
Pain all over the body in last month	0.9	1.0	1.8	-1.3	-0.7	-1.0	-1.1	-0.3	-1.1	-0.5	-0.9	-1.3
Diabetes (self-reported)	0.1	0.1	0.7	-0.9	-0.3	0.1	0.3	-0.2	0.1	-0.1	-0.3	-0.4
Hayfever/allergic rhinitis (self-reported)	1.2	1.6	3.1	1.4	1.8	0.4	1.2	1.3	1.4	0.7	0.9	1.6
Medication: Ramipril	0.2	0.3	0.6	-0.8	-0.6	0.8	0.7	0.3	-0.2	-0.2	0.4	0.6
Medication: Simvastatin	1.0	1.5	5.0	-2.2	-2.0	1.3	-0.2	-1.3	-0.1	-1.0	0.6	0.4
Fluid intelligence score	2.5	5.2	12.6	3.5	3.0	1.1	2.7	2.0	0.3	1.3	2.1	2.5
Illnesses of siblings	0.6	0.9	2.7	0.3	0.3	-1.6	-1.6	0.5	-0.9	0.6	-1.0	-0.2
Neuroticism score	0.5	1.0	3.9	-1.5	-0.4	0.3	-0.9	0.9	-2.0	0.5	-0.4	-0.8
Weight	0.1	0.3	1.5	0.0	0.4	0.8	-0.2	0.4	-1.2	0.4	0.0	0.4
Impedance of arm (right)	0.1	0.3	1.1	-1.1	-0.2	-0.2	0.4	-0.5	-0.2	-1.0	-0.4	0.3
Arm fat percentage (right)	0.9	3.4	10.0	-2.6	-1.5	1.9	-1.2	-0.8	-3.2	-1.8	-1.4	0.2
Trunk fat-free mass	0.5	2.6	7.8	2.8	2.4	0.1	0.6	1.9	0.8	2.2	1.0	-0.1
Hip circumference	0.2	0.8	3.0	0.4	0.9	0.6	0.6	0.7	-1.7	0.7	0.3	1.0
Time employed in main current job	1.4	1.6	4.3	1.6	1.7	-0.1	0.0	2.1	-0.5	-0.5	-0.2	1.9
Alcohol intake versus 10 years previously	1.6	2.4	8.4	-1.4	-1.6	2.5	0.4	-2.9	-0.6	-1.4	0.0	0.5
Father’s age at death	0.8	1.1	3.0	1.6	1.1	0.9	1.7	0.2	0.4	0.7	1.1	0.4
Worrier / anxious feelings	0.3	0.5	1.0	-0.9	-0.6	0.8	0.5	-0.7	-1.0	-0.1	-0.1	-1.0
Frequency of tiredness / lethargy in last 2 weeks	1.6	2.5	9.1	-2.7	-1.6	0.8	-0.4	-0.1	-3.0	-1.3	-1.0	-0.6
Falls in the last year	2.3	3.1	6.7	-2.3	-2.0	-0.6	-1.6	-1.4	-1.1	-2.6	-2.5	-0.5
Hair/balding pattern: Pattern 3	2.0	3.0	9.5	-1.1	0.2	2.4	3.1	0.7	-2.0	0.1	1.4	1.9
Number of live births	0.4	0.6	2.0	-0.8	0.0	1.0	0.4	0.7	0.5	1.4	0.8	0.8
Forced expiratory volume in 1-second (FEV1)	0.2	0.8	4.1	2.0	1.1	0.0	-0.2	0.6	0.2	0.6	0.2	-1.0
Pulse rate	0.6	1.0	2.2	-0.3	-0.6	-1.4	-1.5	-0.4	0.3	-0.8	-1.1	-1.5
Happiness	1.3	1.6	6.6	-2.6	-1.6	0.9	0.2	-0.8	-1.1	-1.5	-0.0	0.2
Noisy workplace	1.9	2.4	4.6	-1.9	-2.1	0.3	-1.6	-1.7	-1.1	-0.9	-1.1	-2.1
Qualifications: A levels/AS levels or equivalent	0.8	1.7	3.8	1.0	0.7	-0.1	2.0	-0.1	1.8	1.6	1.8	0.9
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	2.6	0.3	0.3	0.7	0.7	-0.7	1.6	0.9	1.2	-0.6
Mouth/teeth dental problems: Dentures	1.0	1.6	4.8	-2.2	-2.2	1.1	-1.3	-1.1	-0.3	-0.8	0.5	-0.3
Asthma	0.5	1.0	4.3	-2.1	-1.3	0.1	-0.6	-0.5	0.4	-0.5	-1.2	0.7
Medication: Ibuprofen (e.g. Nurofen)	1.1	1.4	4.5	-1.2	-0.2	1.0	-1.7	0.5	-2.1	0.1	-1.3	-0.9
Medication: Cholesterol lowering	0.3	0.5	1.2	-1.1	-0.8	0.7	0.5	-0.0	0.5	-0.2	0.8	1.0
Depression (self-reported)	0.2	0.2	1.8	-0.3	-0.3	-0.0	-0.1	-0.0	0.3	0.0	-0.4	-1.3
Medication: Lansoprazole	0.4	0.4	1.5	0.9	0.4	0.5	-0.4	0.5	0.9	0.5	1.2	-0.2
Prospective memory result	1.0	1.2	3.4	-0.8	-0.8	-0.1	-0.9	-1.3	0.1	-0.9	-1.7	-1.8
Lung cancer (father)	0.3	0.3	1.0	0.4	0.9	0.4	-0.3	0.7	-0.2	0.5	0.2	-1.0
Illnesses of mother	0.4	0.5	1.4	1.2	1.2	-0.6	0.7	0.8	-0.3	0.5	-0.2	0.3
Forced expiratory volume in 1-second (FEV1), Best measure	0.3	0.9	4.4	2.1	1.0	-0.1	-0.6	0.6	-0.2	0.2	-0.0	-1.3
Pulse wave Arterial Stiffness index	1.0	1.2	5.0	-0.5	-1.5	0.5	-0.7	-2.2	0.5	-0.8	0.6	-0.9
Impedance of arm (left)	0.1	0.4	1.3	-0.7	0.1	-0.3	1.1	-0.5	-0.1	-1.0	-0.1	0.9
Arm fat mass (right)	0.4	1.8	7.0	-1.6	-0.9	1.5	-0.9	-0.4	-2.6	-1.0	-1.1	0.0
Trunk predicted mass	0.4	2.6	7.6	2.8	2.3	0.1	0.6	1.9	0.8	2.1	0.9	-0.1
Standing height	0.6	6.0	14.8	3.9	3.3	-1.3	1.7	2.5	2.5	2.6	2.0	0.3
Length of working week for main job	0.3	0.4	1.0	-0.8	-0.6	1.0	-0.3	-0.9	0.0	-0.0	0.5	0.3
Exposure to tobacco smoke at home	0.2	0.2	0.5	-0.3	-0.3	-0.3	-0.4	-0.4	-0.3	-0.7	-0.3	0.5
Breastfed as a baby	0.8	1.0	2.7	0.8	1.3	-0.2	1.4	1.0	0.8	0.1	0.9	1.6
Tense / ‘highly strung’	1.1	1.8	5.3	-2.3	-1.5	0.2	-1.8	-0.0	-1.6	-0.4	-0.9	-1.4
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.4	1.2	-1.0	-0.3	-1.1	0.1	1.0	0.0	0.3	-0.1	-0.4
Hair/balding pattern: Pattern 4	2.6	6.3	35.2	-2.7	-1.7	0.6	-0.3	-1.2	-5.9	-2.5	-1.5	1.1
Birth weight of first child	1.4	2.5	4.7	2.0	2.2	0.7	1.9	1.2	-1.9	1.3	1.3	1.0
Peak expiratory flow (PEF)	0.5	1.2	3.2	1.8	1.3	-0.9	-1.0	0.2	0.3	-0.1	-1.6	-1.2
Pulse wave reflection index	1.2	1.5	4.0	1.2	-0.1	1.2	0.8	-0.8	1.9	1.0	2.0	0.5
Ever highly irritable/argumentative for 2 days	1.4	1.7	4.1	-1.6	-1.6	-0.3	-1.1	-1.0	-0.9	-1.3	-2.0	-1.3
Loud music exposure frequency	1.2	1.3	3.9	-2.0	-1.3	1.7	-0.1	-0.7	-1.3	-0.9	-0.6	-0.4
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	4.6	1.7	1.4	1.0	2.1	1.3	0.8	1.7	2.1	0.0
Mouth/teeth dental problems: Bleeding gums	1.4	1.7	4.9	-1.9	-1.2	-1.1	-2.2	-0.4	-0.7	-1.1	-1.6	-0.5
Blood clot in the leg (DVT)	1.3	1.7	4.5	0.7	1.5	2.1	1.5	0.9	0.9	1.1	0.8	1.4
Medication: Paracetamol	3.4	5.7	8.0	-2.8	-2.7	0.1	-2.3	-2.5	-2.7	-2.4	-2.1	-2.7
Headache pain in last month	1.3	2.2	4.8	-2.2	-1.8	0.1	-1.1	-1.6	-2.0	-1.5	-1.1	-0.5
Medication for cholesterol, blood pressure or diabetes	0.3	0.4	1.5	1.1	0.6	0.2	-0.6	-0.1	0.5	0.2	-0.0	-1.2
Glaucoma (self-reported)	0.5	0.6	1.7	0.6	0.8	-0.3	0.1	1.3	1.1	0.6	0.5	0.6
Gout (self-reported)	3.3	4.5	7.3	-2.7	-2.7	-2.3	-1.2	-2.5	-1.9	-2.3	-1.5	-1.3
Hypothyroidism/myxoedema (self-reported)	1.1	2.2	3.5	-1.4	-1.9	-1.4	-1.7	-1.9	-0.4	-1.7	-0.9	-1.5
Medication: Amlodipine	0.3	0.4	0.9	-0.6	-0.7	-0.9	-0.4	0.8	0.9	0.3	-0.3	-0.5
Medication: Ventolin 100micrograms inhaler	0.5	0.6	1.7	0.1	0.5	-1.2	-0.3	0.9	0.9	0.3	-0.6	1.3
Birth weight	0.5	1.2	5.2	1.3	0.7	0.2	-1.0	-0.0	-1.4	-0.1	-0.5	-2.3
Chronic bronchitis/emphysema (mother)	2.4	2.8	5.2	-2.3	-2.1	-0.4	-1.8	-1.9	-0.7	-1.5	-1.4	-2.1
High blood pressure (siblings)	0.4	0.5	2.0	0.0	-0.3	1.1	-0.2	0.3	1.4	-0.2	1.0	-0.5
Forced vital capacity (FVC), Best measure	0.3	1.2	6.4	2.5	1.5	-0.3	0.1	1.0	0.2	0.7	0.4	-0.8
Body fat percentage	0.8	3.2	10.2	-2.6	-1.6	1.6	-1.2	-0.9	-3.2	-1.6	-1.2	0.6
Leg fat percentage (right)	0.9	3.4	10.0	-2.6	-1.9	1.7	-1.6	-1.1	-3.2	-1.4	-1.3	0.4
Arm fat-free mass (right)	0.2	1.3	4.2	2.0	1.5	0.0	0.4	1.2	0.3	1.6	1.0	0.0
Exposure to tobacco smoke outside home	1.1	1.4	2.5	-1.0	-1.4	-1.0	-1.6	-0.8	1.6	-0.8	-0.9	-1.2
Comparative body size at age 10	0.6	1.8	5.6	0.1	0.9	2.4	2.0	0.7	-0.4	1.5	1.6	0.5
Number of full brothers	2.9	3.7	7.3	-2.4	-2.7	-0.6	-2.2	-2.1	-1.2	-2.3	-1.1	-1.5
Worry too long after embarrassment	3.8	6.4	15.2	2.1	3.1	0.9	2.9	2.8	-0.2	3.9	2.4	2.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	0.9	2.8	-1.3	-1.7	-0.5	-1.0	-0.6	-1.1	-0.7	-0.5	-0.5
Wheeze or whistling in the chest in last year	2.1	3.8	11.4	-3.4	-2.6	0.6	-2.2	-0.8	-1.5	-1.3	-1.7	-1.8
Number of children fathered	0.7	0.8	4.4	0.7	-0.7	0.3	-0.6	-0.6	-2.1	-0.4	-0.7	-0.3
Reason for reducing amount of alcohol drunk: Health precaution	1.2	1.4	4.5	1.0	1.7	-1.5	0.1	2.1	-0.4	0.5	-0.8	-0.7
Age at first live birth	3.0	5.3	11.6	3.4	2.6	0.5	2.9	1.6	1.9	2.2	2.8	1.3
Pulse wave peak to peak time	1.0	1.2	5.2	0.4	1.5	-0.7	0.6	2.3	-0.4	0.7	-0.7	0.9
Health satisfaction	1.6	2.1	7.8	-2.8	-1.3	0.2	-0.1	-0.0	-1.7	-1.7	-1.0	-1.8
Shortness of breath walking on level ground	0.8	1.0	4.5	-0.3	-0.2	0.3	-1.6	0.5	-0.5	-0.1	-1.0	-2.1
Qualifications: College or University degree	2.1	6.6	13.9	3.0	3.3	0.2	3.7	2.3	1.6	2.3	2.4	2.6
Eye problems/disorders: None of the above	0.3	0.3	0.7	-0.5	-0.2	-0.1	0.1	-0.7	-0.9	-0.7	-0.5	-0.9
Mouth/teeth dental problems: Loose teeth	0.5	0.6	2.0	0.5	0.8	-1.4	-0.9	0.4	0.3	0.9	-0.3	-0.6
Emphysema/chronic bronchitis	4.1	4.6	9.1	-2.5	-2.1	0.8	-1.9	-2.0	-2.2	-3.0	-2.0	-2.4
Medication for pain relief, constipation, heartburn	3.6	6.2	10.3	3.2	3.0	-1.8	2.4	1.9	2.6	2.4	1.7	2.9
Neck or shoulder pain in last month	0.9	1.3	3.2	-1.8	-1.5	-0.3	-0.9	-1.3	-0.1	-1.2	-1.5	0.5
Medication: Blood pressure	0.3	0.5	2.0	-1.4	-1.1	-0.4	-0.2	-0.2	-0.6	-0.4	-0.5	0.1
Angina (self-reported)	1.0	1.3	3.2	-1.6	-1.8	1.8	0.7	-0.8	0.9	-0.4	-0.0	0.8
Migraine (self-reported)	0.1	0.1	0.4	0.4	-0.1	-0.6	0.4	-0.3	0.1	0.1	0.2	0.6
Medication: Ibuprofen	0.7	0.9	2.2	-1.2	-0.6	0.2	-1.5	-0.1	-1.3	-0.3	-1.2	-0.8
Medication: Allopurinol	4.2	5.6	11.5	-3.3	-3.4	-1.1	-1.7	-3.1	-1.8	-2.8	-1.4	-1.4
Medication: Omeprazole	1.8	2.1	6.7	-2.6	-1.7	1.5	-1.2	0.1	-1.1	-1.5	-1.6	0.0
Medication: Seretide 50 evohaler	0.8	1.0	4.0	-0.2	-0.8	-0.9	-0.1	-0.8	2.0	0.8	0.9	1.1
Mean time to correctly identify matches	1.4	2.6	6.2	-2.5	-2.2	0.8	0.6	-2.3	-1.4	-1.6	0.2	1.4
Heart disease (mother)	1.3	1.5	3.8	-1.5	-1.6	0.9	-1.0	-1.1	-0.6	-1.9	-1.2	-0.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.8	6.6	-1.6	-2.3	-0.7	-1.7	-2.6	0.1	-2.0	-1.6	-0.8
Whole body fat mass	0.4	1.6	7.1	-1.4	-0.8	1.4	-0.9	-0.4	-2.7	-0.8	-0.8	0.5
Leg fat mass (right)	0.4	1.5	6.0	-1.5	-1.0	1.1	-1.2	-0.4	-2.5	-0.9	-0.9	0.4
Arm predicted mass (right)	0.2	0.8	3.0	1.7	1.4	-0.0	0.2	1.0	0.1	1.2	0.6	-0.1
Pulse rate, automated reading	0.7	2.2	4.5	-1.1	-1.5	-2.1	-1.6	-1.1	-0.1	-1.8	-1.9	-1.1
Alcohol intake frequency.	0.6	1.5	4.6	-1.6	-1.8	0.3	0.0	-2.1	-0.9	-0.8	0.3	1.2
Comparative height size at age 10	0.8	4.7	10.0	1.9	1.7	-0.3	1.9	1.5	3.1	2.5	3.2	1.8
Number of full sisters	2.5	3.1	9.1	-2.0	-1.2	-1.0	-1.9	-0.6	-1.2	-1.2	-2.4	-3.0
Suffer from ‘nerves’	0.2	0.4	0.9	-0.9	-0.0	-0.3	-0.3	0.4	-0.9	0.9	-0.1	-0.7
Overall health rating	2.4	5.1	14.7	-3.8	-2.6	1.8	-1.3	-0.1	-3.8	-1.5	-1.6	-0.3
Chest pain or discomfort	1.8	2.5	4.9	-2.2	-2.2	0.7	-1.5	-0.6	-2.2	-1.8	-1.5	-0.5
Had major operations	0.6	0.7	3.0	-0.2	-0.5	0.2	-0.7	0.7	-1.7	-0.2	-1.2	-0.7
Age at last live birth	2.0	3.0	5.1	1.7	1.9	0.3	2.1	1.6	1.8	2.3	1.9	1.2
Family relationship satisfaction	1.7	2.1	4.5	-2.1	-1.9	1.0	-1.1	-1.3	-0.4	-1.1	-1.3	-1.7
Leg pain on walking	1.2	1.4	5.0	-1.2	-0.5	1.0	-0.6	0.5	-2.2	0.2	-1.1	-1.9
Qualifications: NVQ or HND or HNC or equivalent	0.5	0.6	1.7	-1.3	-0.9	0.4	-0.8	-1.1	0.5	-0.4	0.0	-0.6
Commuting to job workplace: Car/motor vehicle	0.4	0.5	1.5	-0.5	-0.7	-0.4	-0.0	-0.9	1.2	-0.9	-0.1	-0.6
Illness, injury, bereavement, stress in last 2 years	0.3	0.4	1.4	0.5	-0.0	-0.1	1.0	-0.4	-0.3	-0.7	0.1	1.2
Medication: Aspirin	2.8	3.7	10.4	-2.9	-3.2	1.2	-1.2	-2.4	-0.5	-1.8	-0.8	-1.4
Supplements: Vitamin C	0.4	0.4	1.4	-0.4	-0.4	-0.0	-1.0	-0.0	0.3	-1.2	-0.6	-1.0
Knee pain experienced in last month	1.3	2.0	4.1	-1.9	-1.2	1.1	-1.3	-0.3	-2.0	-1.3	-1.8	-1.1
Hypertension (Self-reported)	0.3	0.9	4.0	-2.0	-1.5	-0.5	-0.8	-0.5	-0.2	-0.9	-0.1	0.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.8	0.9	2.0	-1.3	-0.9	0.8	-1.2	0.9	0.3	-1.4	-0.8	0.7
Illnesses of father: Heart disease	0.3	0.4	1.0	-0.5	-1.0	0.6	0.7	-0.6	0.2	-0.2	0.5	0.8
Illnesses of siblings: Diabetes	1.0	1.2	3.5	-1.6	-1.9	0.6	-0.2	-1.6	-0.2	-0.8	0.7	-0.4
Smoking status: Previous	0.2	0.3	1.1	-0.9	-0.2	0.3	-0.2	-0.2	-1.1	-0.2	-0.3	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.7	1.4	3.6	-0.9	-1.3	-1.2	-1.7	-0.9	-0.5	-0.4	-0.6	-1.9
Whole body fat-free mass	0.4	2.1	6.0	2.5	2.2	0.1	0.6	1.7	0.7	1.9	1.1	-0.0
Leg fat-free mass (right)	0.3	1.4	3.4	1.8	1.9	0.2	0.6	1.3	0.6	1.5	1.3	0.1
Arm fat percentage (left)	0.8	3.1	10.1	-2.4	-1.4	1.8	-0.9	-0.9	-3.2	-1.7	-1.4	0.5
Average weekly red wine intake	0.7	1.0	3.1	0.4	0.9	0.5	0.5	1.4	1.2	1.8	0.9	-0.2
Handedness (chirality/laterality): Left-handed	0.6	0.8	1.7	1.0	1.3	-0.4	0.4	1.0	-0.5	1.1	-0.4	1.1
Mood swings	0.4	0.8	3.3	-1.8	-1.2	1.3	-0.2	0.2	-0.8	0.3	0.3	0.0
Loneliness, isolation	4.5	6.2	12.4	-3.5	-2.9	-0.4	-2.7	-2.1	-2.9	-2.5	-2.2	-1.9
Long-standing illness, disability or infirmity	0.7	1.1	3.2	-1.6	-0.4	1.8	0.8	-0.0	-0.3	-1.2	-0.4	1.2
Ever had bowel cancer screening	0.5	0.5	2.2	-0.7	-0.5	-0.4	1.5	-0.6	-0.3	0.4	0.5	0.9
Diabetes diagnosed by doctor	1.0	1.6	5.1	-2.3	-1.8	-0.0	-0.8	-1.5	-0.3	-1.0	-0.8	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.2	1.3	4.5	-2.1	-1.8	-1.3	-0.4	-0.9	0.6	-0.7	0.4	-0.4
Friendships satisfaction	1.9	2.3	4.6	-2.2	-1.4	1.5	-0.4	-0.7	-2.1	-1.8	-1.1	-1.4
Qualifications: nursing, teaching	1.4	2.2	6.2	1.3	1.6	0.5	2.5	0.5	1.3	0.9	1.6	2.0
Commuting to job workplace: Walk	0.3	0.3	1.0	-0.2	-0.0	0.4	0.8	-0.4	-0.7	0.2	0.7	1.0
Eye problems/disorders: Cataract	0.6	0.7	2.4	1.1	0.6	1.6	0.4	0.4	0.3	0.5	0.6	1.2
Mouth/teeth dental problems: Mouth ulcers	1.8	2.8	7.7	-2.8	-1.2	0.9	-1.9	0.1	-2.1	-1.0	-2.5	-0.8
Medication for cholesterol	1.9	2.9	5.1	2.3	2.2	1.2	2.1	1.5	-0.4	2.0	1.9	0.9
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.2	2.1	-0.8	-1.1	-0.9	-1.4	-1.2	-1.0	-0.7	-1.1	-1.4
Back pain experienced in last month	0.5	0.7	1.7	-1.1	-1.2	1.0	-1.3	-0.7	-0.4	-0.5	-0.2	0.5
Mineral and other dietary supplements	0.7	0.9	3.1	0.8	1.8	-0.7	-0.4	1.7	0.3	0.8	-0.1	-0.3
Breast cancer (self-reported)	0.6	0.7	1.4	1.0	1.0	1.2	0.5	0.6	0.9	0.8	0.9	0.4
Asthma (self-reported)	0.4	0.7	3.2	-1.8	-1.1	0.1	-0.5	-0.2	0.6	-0.2	-0.9	0.9
Osteoporosis (self-reported)	0.9	1.1	3.1	-1.3	-1.4	-0.3	-0.7	-0.5	-1.8	-1.2	0.5	-0.7
Osteoarthritis (self-reported)	0.5	0.7	2.5	0.4	0.7	1.0	1.6	0.4	0.6	0.0	1.0	0.5
Medication: Aspirin	3.1	4.1	12.1	-3.1	-3.5	0.6	-1.2	-2.6	-0.5	-1.9	-0.7	-1.5
Medication: Gliclazide	1.0	1.1	3.2	-0.7	-0.4	1.3	-0.2	0.1	-1.2	-1.8	-0.9	-1.4
Illnesses of father: None of the above (group 1)	2.2	2.7	9.3	-0.6	-1.1	-0.6	-2.5	-1.1	-1.0	-1.5	-1.5	-3.0
Smoking status: Current	5.1	8.1	16.3	-4.0	-3.9	0.7	-3.4	-2.4	-2.0	-2.7	-2.9	-2.0
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.4	0.8	4.8	0.8	0.0	0.4	0.7	0.0	-2.2	-0.7	0.7	-0.0
Whole body water mass	0.3	1.9	5.4	2.3	2.0	0.1	0.5	1.6	0.5	1.8	1.0	-0.1
Leg predicted mass (right)	0.3	1.6	3.6	1.8	1.9	0.3	0.7	1.3	0.6	1.6	1.4	0.2
Arm fat mass (left)	0.4	1.5	6.4	-1.4	-0.6	1.7	-0.6	-0.3	-2.5	-0.8	-0.8	0.5
Number of self-reported non-cancer illnesses	0.6	1.0	3.9	-2.0	-1.2	0.5	0.2	-0.2	0.1	-0.1	0.8	1.7
Average weekly champagne plus white wine intake	0.9	1.2	7.0	1.1	0.2	-2.6	-0.4	-1.2	0.6	0.5	0.5	-0.7
Miserableness	0.2	0.4	1.2	-0.3	0.0	-0.1	-0.3	1.1	-0.9	1.0	-0.0	-0.8
Guilty feelings	1.1	1.7	7.7	-1.5	0.1	0.7	-0.7	1.4	-2.8	0.3	-1.0	-1.1
Wears glasses or contact lenses	1.6	1.8	4.2	1.2	1.0	0.5	1.4	0.8	2.0	1.0	1.8	1.5
Ever taken oral contraceptive pill	0.1	0.1	0.4	-0.4	-0.3	0.4	0.2	0.2	0.3	0.1	0.6	-0.1
Hearing aid user	1.7	1.9	3.5	1.2	1.9	0.4	1.7	1.6	1.8	0.9	0.6	1.6
Mother’s age at death	0.4	0.5	1.8	0.4	0.7	-1.3	-0.6	1.1	-0.1	-0.4	-0.5	-0.6
Financial situation satisfaction	4.2	5.2	13.9	-3.7	-2.9	1.0	-1.9	-1.8	-2.6	-2.0	-1.8	-1.4
Tinnitus: Yes, now most or all of the time	0.2	0.3	1.2	0.3	0.5	-0.8	0.5	1.1	0.4	-0.0	0.1	-0.0
Commuting to job workplace: Public transport	0.3	0.3	1.4	-0.0	0.0	0.3	-0.9	0.1	1.2	0.9	-0.1	-0.2
Eye problems/disorders: Glaucoma	0.1	0.1	0.6	-0.2	0.1	-0.0	-0.3	0.8	0.3	0.5	-0.2	0.1
Medication: Blood pressure	1.0	1.9	3.8	-1.3	-1.8	-1.9	-1.4	-1.1	0.9	-1.9	-0.5	-0.6
Pain type(s) experienced in last month: Hip pain	0.5	0.7	2.0	-0.7	-0.4	0.5	-1.4	0.4	-1.0	0.9	-0.0	-1.0
Supplements: Fish oil (including cod liver oil)	0.8	1.0	2.8	-0.5	-0.7	1.2	1.7	-0.5	0.1	0.3	0.9	1.7
High cholesterol (Self-reported)	0.6	1.1	3.1	-1.1	-1.8	1.0	-0.7	-1.1	1.6	-0.7	0.6	0.3
Medication: Bendroflumethiazide	0.3	0.5	1.6	0.2	0.5	-0.5	0.1	1.0	1.1	0.2	0.3	1.2
Medication: Paracetamol	2.6	4.1	7.0	-1.9	-2.2	-0.6	-2.1	-1.8	-1.9	-2.3	-2.1	-2.6
Medication: Lisinopril	1.2	1.6	4.2	-1.0	-1.3	-2.0	0.1	-1.7	1.7	-1.0	-0.0	-0.7
Medication: Atorvastatin	0.2	0.3	1.2	-0.4	-0.2	0.1	1.1	-0.1	-0.1	-0.5	-0.6	0.8
Illnesses of father: High blood pressure	0.6	0.7	1.3	0.2	0.8	1.0	0.8	1.1	0.6	1.0	0.5	1.2
Alcohol drinker status: Never	0.2	0.3	0.8	0.2	-0.6	-0.9	-0.9	-0.3	-0.6	-0.4	-0.1	-0.1
Ever smoked	1.1	1.9	4.0	-2.0	-1.4	0.6	-1.1	-1.0	-1.9	-1.2	-1.6	-0.7
Basal metabolic rate	0.2	1.2	3.1	1.8	1.7	0.3	0.3	1.4	0.0	1.5	0.7	-0.1
Leg fat percentage (left)	1.3	4.8	12.9	-3.2	-2.4	2.0	-1.9	-1.4	-3.6	-1.7	-1.5	0.2
Arm fat-free mass (left)	0.1	0.7	2.1	1.4	1.2	0.3	-0.1	1.2	0.1	1.1	0.4	-0.3
Number of operations (self-reported)	0.3	0.5	2.6	-0.3	-0.2	-0.3	-0.8	0.7	-1.6	0.6	0.2	0.4
Average weekly beer plus cider intake	1.0	1.5	4.8	0.0	-0.6	-2.2	-2.0	-0.4	0.9	-1.0	-1.1	-0.8
Irritability	3.9	6.6	21.7	-4.7	-3.7	-0.7	-2.5	-2.3	-1.6	-2.0	-1.8	-1.6
Risk taking	1.4	2.1	8.6	-1.1	-0.5	-1.4	-0.9	-0.1	-2.0	-1.4	-2.9	-0.0
Ever had prostate specific antigen (PSA) test	1.0	1.2	3.9	-0.6	-0.8	-1.2	-1.3	0.3	-1.0	-1.1	-0.7	-2.0
Fractured/broken bones in last 5 years	0.4	0.6	1.5	-1.2	-1.1	1.1	0.9	-0.6	-0.0	0.3	0.1	0.4
Age started oral contraceptive pill	4.2	5.3	11.4	2.9	2.3	1.2	2.8	1.9	1.1	1.6	2.4	3.4
Diastolic blood pressure, automated reading	0.1	0.4	1.1	-1.0	-1.0	0.5	-0.5	-0.6	0.3	-0.3	0.1	-0.3
Ever depressed for a whole week	0.4	0.5	1.7	-0.7	-1.0	0.0	-0.7	0.1	0.1	0.7	0.1	-1.3
Unable to work because of sickness or disability	0.9	1.2	3.1	-1.6	-1.4	-0.4	-1.2	-0.9	-0.5	-0.3	-0.5	-1.8
Commuting to job workplace: Cycle	0.2	0.3	0.8	-0.1	-0.1	-0.4	-0.5	-0.5	-0.9	-0.8	-0.7	0.1
Myopia	1.3	1.9	3.8	1.1	1.4	-0.8	0.7	1.3	1.8	1.9	1.9	0.4
Vascular/heart problems diagnosed by doctor	0.4	1.0	3.8	1.9	1.4	0.2	0.3	0.7	-0.2	0.9	-0.2	-1.4
Cholesterol lowering medication	1.5	2.2	6.6	-2.1	-2.6	0.2	-1.3	-1.9	-0.1	-1.6	-0.8	-0.7
Medication: Omeprazole (e.g. Zanprol)	1.5	1.9	6.3	-2.5	-1.6	1.3	-1.0	0.4	-0.8	-1.4	-1.4	-0.5
Pain experienced in last month	1.2	2.0	5.4	2.3	1.9	-0.7	1.4	0.8	2.0	0.8	1.2	0.4
Supplements: Calcium	0.2	0.2	0.7	-0.3	-0.4	0.4	0.2	0.3	-0.8	-0.5	-0.1	0.3
Basal cell carcinoma (self-reported)	2.7	3.2	6.1	-2.2	-2.1	-0.6	-2.5	-1.1	-2.3	-1.6	-1.0	-1.9
Heart attack/myocardial infarction (self-reported)	0.8	1.0	3.1	-1.3	-1.8	0.3	0.3	-1.3	1.0	-0.6	0.4	0.9
Deep venous thrombosis (DVT) (self-reported)	0.9	1.2	3.3	0.5	1.3	1.8	1.3	0.6	0.9	0.8	0.6	1.1
Heart disease (siblings)	0.3	0.3	0.9	-0.2	-0.1	-0.4	0.9	-0.5	0.5	-0.5	-0.7	-0.9
Alcohol drinker status: Previous	0.3	0.3	0.9	-0.7	-0.2	-0.8	-0.6	0.1	-0.3	-0.4	-0.2	-1.0
Pack years of smoking	1.5	2.2	4.1	-2.0	-1.8	1.5	-1.7	-1.1	-1.4	-1.3	-1.2	-1.0
Impedance of whole body	0.1	0.6	1.5	-1.2	-0.7	-0.7	0.0	-0.7	-0.4	-1.2	-0.7	0.1
Leg fat mass (left)	0.5	2.0	7.2	-1.8	-1.2	1.5	-1.3	-0.6	-2.7	-1.0	-0.9	0.4
Arm predicted mass (left)	0.1	0.8	2.3	1.5	1.1	0.2	-0.2	1.1	-0.1	1.3	0.4	-0.4