Best TWAS P=1.41e-09 · Best GWAS P=3.85e-10 conditioned to 0.000102
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Brain Frontal Cortex BA9 | ATP6V1E2 | 0.40 | -0.01 | enet | 35 | 0.06 | 1.4e-02 | 3.8 | -5.4 | 5.5e-08 | -0.28 | 0.10 | 0.16 | FALSE |
| 2 | GTEx | Brain Nucleus accumbens basal ganglia | CRIPT | 0.27 | -0.01 | enet | 8 | 0.02 | 1.2e-01 | 4.8 | 5.5 | 4.1e-08 | 0.72 | 0.06 | 0.55 | FALSE |
| 3 | GTEx | Colon Sigmoid | ATP6V1E2 | 0.25 | 0.08 | enet | 17 | 0.13 | 3.3e-05 | 4.3 | -5.3 | 1.3e-07 | -0.81 | 0.13 | 0.81 | FALSE |
| 4 | GTEx | Esophagus Gastroesophageal Junction | AC016722.2 | 0.30 | 0.07 | lasso | 4 | 0.11 | 7.7e-05 | 4.6 | -6.0 | 2.0e-09 | -0.84 | 0.09 | 0.64 | FALSE |
| 5 | GTEx | Skin Not Sun Exposed Suprapubic | PIGF | 0.14 | 0.08 | lasso | 4 | 0.07 | 1.7e-04 | 5.8 | -6.0 | 1.4e-09 | -0.47 | 0.06 | 0.89 | TRUE |
| 6 | GTEx | Testis | SOCS5 | 0.17 | 0.01 | lasso | 3 | 0.03 | 1.2e-02 | -4.0 | -5.5 | 4.4e-08 | -0.31 | 0.11 | 0.44 | FALSE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | ATP6V1E2 | 0.11 | 0.04 | blup | 75 | 0.06 | 2.0e-04 | 3.8 | -5.5 | 3.7e-08 | -0.77 | 0.06 | 0.91 | FALSE |
| 8 | The Cancer Genome Atlas | Prostate Adenocarcinoma | ATP6V1E2 | 0.04 | 0.02 | lasso | 3 | 0.02 | 4.6e-03 | 5.8 | -5.6 | 1.8e-08 | -0.89 | 0.01 | 0.97 | FALSE |
| 9 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | CRIPT | 0.13 | 0.09 | blup | 66 | 0.06 | 5.1e-03 | 5.8 | 5.6 | 2.6e-08 | 0.58 | 0.01 | 0.94 | FALSE |