Best TWAS P=5.71e-14 · Best GWAS P=8.37e-26 conditioned to 3.81e-08
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | RP11-755B10.4 | 0.11 | 0.06 | lasso | 11 | 0.04 | 1.4e-02 | 6.5 | -6.5 | 8.6e-11 | -0.30 | 0.28 | 0.07 | FALSE |
| 2 | GTEx | Artery Tibial | RP11-755B10.4 | 0.11 | 0.06 | enet | 13 | 0.04 | 2.1e-04 | 6.5 | -7.1 | 1.5e-12 | -0.32 | 0.55 | 0.03 | TRUE |
| 3 | GTEx | Brain Caudate basal ganglia | FLNB | 0.17 | 0.10 | lasso | 12 | 0.12 | 2.3e-04 | -2.3 | 5.3 | 1.3e-07 | 0.12 | 0.32 | 0.04 | FALSE |
| 4 | GTEx | Brain Caudate basal ganglia | FLNB-AS1 | 0.17 | 0.04 | lasso | 7 | 0.10 | 8.7e-04 | 6.5 | 6.6 | 3.5e-11 | 0.22 | 0.28 | 0.05 | FALSE |
| 5 | GTEx | Cells EBV-transformed lymphocytes | CCDC66 | 0.45 | 0.27 | enet | 37 | 0.29 | 3.7e-10 | -6.4 | -6.0 | 2.5e-09 | -0.03 | 0.38 | 0.62 | FALSE |
| 6 | GTEx | Cells Transformed fibroblasts | FAM208A | 0.10 | 0.00 | lasso | 4 | 0.00 | 1.3e-01 | -6.6 | 5.4 | 6.1e-08 | 0.02 | 0.06 | 0.83 | FALSE |
| 7 | GTEx | Liver | PDE12 | 0.23 | 0.00 | enet | 20 | 0.03 | 6.6e-02 | 3.9 | -6.7 | 2.0e-11 | -0.61 | 0.05 | 0.40 | TRUE |
| 8 | GTEx | Pituitary | CCDC66 | 0.16 | 0.16 | enet | 31 | 0.12 | 6.8e-04 | -2.1 | 5.6 | 1.6e-08 | 0.03 | 0.05 | 0.80 | FALSE |
| 9 | ROSMAP | Brain Pre-frontal Cortex | ARF4 | 0.12 | 0.15 | lasso | 7 | 0.16 | 1.4e-19 | 3.9 | 5.8 | 8.0e-09 | 0.59 | 1.00 | 0.00 | FALSE |
| 10 | YFS | Blood | CCDC66 | 0.11 | 0.09 | lasso | 8 | 0.11 | 6.0e-34 | -6.3 | -6.6 | 4.0e-11 | -0.02 | 0.43 | 0.57 | FALSE |
| 11 | The Cancer Genome Atlas | Breast Invasive Carcinoma | CCDC66 | 0.09 | 0.03 | lasso | 8 | 0.05 | 4.2e-11 | -4.6 | -6.0 | 2.2e-09 | -0.01 | 0.31 | 0.69 | FALSE |
| 12 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | CCDC66 | 0.05 | 0.05 | blup | 56 | 0.06 | 1.0e-07 | -6.7 | -7.5 | 5.7e-14 | -0.02 | 0.01 | 0.99 | TRUE |
| 13 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | C3orf63 | 0.03 | 0.01 | enet | 4 | 0.01 | 1.3e-02 | -6.6 | 6.0 | 2.0e-09 | 0.01 | 0.01 | 0.84 | FALSE |
| 14 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC66 | 0.09 | 0.05 | blup | 56 | 0.06 | 5.3e-07 | -6.4 | -7.1 | 1.4e-12 | -0.04 | 0.13 | 0.87 | FALSE |
| 15 | The Cancer Genome Atlas | Brain Lower Grade Glioma | CCDC66 | 0.16 | 0.13 | enet | 12 | 0.16 | 3.1e-17 | -6.3 | -5.7 | 1.0e-08 | -0.01 | 0.13 | 0.87 | FALSE |
| 16 | The Cancer Genome Atlas | Lung Adenocarcinoma | CCDC66 | 0.05 | 0.06 | blup | 56 | 0.05 | 9.7e-07 | -6.7 | -7.4 | 1.1e-13 | -0.03 | 0.01 | 0.99 | FALSE |
| 17 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | CCDC66 | 0.03 | 0.03 | blup | 56 | 0.03 | 9.6e-05 | -5.1 | -6.3 | 4.0e-10 | -0.02 | 0.13 | 0.72 | FALSE |
| 18 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | CCDC66 | 0.08 | 0.01 | blup | 56 | 0.07 | 7.2e-04 | -6.3 | -5.2 | 2.2e-07 | -0.01 | 0.07 | 0.41 | FALSE |
| 19 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CCDC66 | 0.15 | 0.10 | enet | 11 | 0.13 | 7.3e-14 | -5.1 | -5.2 | 1.9e-07 | 0.00 | 0.22 | 0.78 | FALSE |
| 20 | The Cancer Genome Atlas | Rectum Adenocarcinoma | CCDC66 | 0.20 | -0.01 | lasso | 3 | 0.00 | 3.0e-01 | -5.1 | -5.3 | 1.5e-07 | -0.03 | 0.02 | 0.38 | FALSE |
| 21 | The Cancer Genome Atlas | Stomach Adenocarcinoma | CCDC66 | 0.05 | 0.01 | blup | 57 | 0.02 | 8.4e-03 | -4.6 | -5.8 | 7.7e-09 | -0.01 | 0.08 | 0.46 | FALSE |