Hub : Genes

ARF4

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Cells Transformed fibroblasts 0.184 0.0530 3.5e-09 0.167 NA 0.128 NA 0.156 1.6e-12 NA 8.1e-10 NA 9.1e-12
2 GTEx Colon Transverse 0.204 0.0650 1.1e-05 0.101 NA 0.107 NA 0.124 1.5e-05 NA 9.0e-06 NA 1.7e-06
3 ROSMAP Brain Pre-frontal Cortex 0.120 0.0305 2.8e-16 0.148 0.14 0.146 0.145 0.156 1.6e-18 1.5e-17 2.5e-18 3.7e-18 1.4e-19

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3
Bipolar Disorder (2018) 0.5 0.7 1.1 0.9 0.5 -1.1
Bipolar Disorder or Schizophrenia 0.9 2.2 2.3 1.4 1.5 -1.5
Depressed Affect (Nagel 2018) 2.1 4.5 5.6 -2.3 -1.6 2.4
Depression (Nagel 2018) 2.7 4.1 5.1 -2.3 -1.6 2.2
Intelligence (Savage-Jansen 2018) 1.0 3.1 3.9 -1.7 -1.6 2.0
Neuroticism (Nagel 2018) 1.4 3.3 4.1 -2.0 -1.3 2.0
Schizophrenia (2018) 0.8 1.6 2.3 1.1 1.5 -1.1
Schizophrenia vs Biploar Disorder 0.4 0.5 1.1 0.6 1.0 -0.2
Worry (Nagel 2018) 0.2 0.4 0.4 -0.6 -0.6 0.6
Alzheimer’s Disease (in mother) 1.5 1.7 2.3 -1.5 -1.3 1.1
Alzheimer’s Disease (in father) 0.4 0.5 0.7 -0.8 -0.6 0.6
Alzheimer’s Disease (including proxy) 1.4 2.0 2.9 -1.7 -1.1 1.4
Crohns Disease (2017) 0.9 1.9 4.0 -0.9 -2.0 0.9
Irritable Bowel Disease (IBD) 2.3 5.6 8.6 -2.1 -2.9 1.9
Ulcerative Colitis (UC) 2.0 3.8 5.3 -1.9 -2.3 1.6
Major Depression (MDD) 0.1 0.1 0.4 -0.2 0.6 -0.1
Reaction Time 8.3 15.7 18.3 4.2 3.4 -4.3
Verbal and Numeric Reasoning (VNR) 2.5 6.0 6.7 -2.2 -2.6 2.5
Breast Cancer 0.2 0.4 0.7 -0.6 -0.8 0.5
Ovarian Cancer 0.4 0.5 0.9 -0.8 -0.0 0.9
Prostate Cancer 2.8 3.9 5.3 1.9 2.3 -1.7
Age at First Birth 0.6 0.9 1.1 -1.1 -0.9 0.9
Bipolar Disorder (2011) 0.8 0.8 1.0 -1.0 -1.0 0.7
Body Mass Index (BMI) (2010) 1.7 2.4 3.1 1.7 1.6 -1.3
Coronary Artery Disease (CAD) 1.2 1.4 2.1 1.2 0.9 -1.4
Crohns Disease (2012) 0.3 0.5 0.7 0.5 -0.8 -0.8
Mean Putamen Volume 0.1 0.2 0.4 0.1 -0.6 -0.3
Fasting Glucose 1.2 1.5 1.9 1.4 1.0 -1.3
HbA1C 0.7 0.8 1.0 1.0 0.9 -0.7
HDL Cholesterol 1.4 2.4 3.1 -1.4 -1.5 1.8
LDL Cholesterol 0.2 0.3 0.6 0.6 0.3 -0.8
Lupus 2.2 3.3 4.2 -2.0 -1.5 1.9
Neuroticism (2016) 0.7 1.0 1.5 -1.1 -0.7 1.2
Primary Biliary Cirrhosis 0.1 0.1 0.3 -0.1 0.2 -0.5
Rheumatoid Arthritis 0.7 0.9 2.0 0.7 1.4 -0.5
Schizophrenia (2014) 0.3 0.6 1.2 0.7 1.1 -0.5
Triglycerides 2.8 4.7 5.4 2.1 2.3 -2.1
Type 2 Diabetes (T2D) (2012) 2.7 3.1 3.7 -1.6 -1.9 1.7
Ulcerative Colitis 2.2 3.2 3.7 -1.9 -1.8 1.6
Blood Eosinophil Count 0.5 3.8 6.5 -2.5 -1.3 1.8
Blood Platelet Count 0.1 1.7 3.1 -1.2 1.8 0.7
Blood Red Count 0.1 0.5 1.0 0.7 0.2 -1.0
Blood White Count 2.4 18.0 20.5 -4.5 -3.7 4.4
Heel T-Score 6.9 54.8 59.1 7.7 7.0 -7.5
BMI 0.1 0.6 0.9 0.9 0.7 -0.7
Height 3.7 70.9 84.8 -8.1 -7.8 9.2
Waist Hip Ratio (WHR) 0.2 0.8 1.5 -0.9 -1.2 0.1
Systolic Blood Pressure 1.1 5.7 7.3 2.1 2.7 -2.3
Smoking Status 0.2 0.5 1.0 -0.6 0.2 1.0
Allergy or Eczema 0.3 0.7 0.9 -0.7 -0.9 0.9
Cardiovascular Disease 0.7 2.4 2.7 1.4 1.7 -1.5
Hypothyroidism (self reported) 0.3 0.7 1.3 0.5 1.2 -0.7
Respiratory disease 0.7 1.5 1.7 -1.3 -1.0 1.3
Type 2 Diabetes (T2D) (2018) 0.2 0.4 0.5 0.6 0.7 -0.4
Lung FEV1/FVC ratio 4.2 21.2 32.3 5.0 2.6 -5.7
Lung FVC 2.8 14.1 17.1 4.1 3.1 -4.0
Neuroticism 0.7 1.7 2.3 -1.5 -0.8 1.4
Chronotype (morning person) 0.4 0.9 1.4 -0.8 -1.2 0.8
Hair Pigment 0.0 0.5 0.8 -0.8 -0.9 -0.3
Tanning 0.0 0.2 0.4 -0.5 -0.3 0.7
Hand grip strength (left) 0.4 1.0 2.9 -0.1 -1.7 0.2
Number of treatments/medications taken 0.1 0.2 0.2 -0.2 0.4 0.5
Average weekly spirits intake 0.0 0.0 0.0 0.2 0.1 0.1
Sensitivity / hurt feelings 0.0 0.1 0.1 0.1 0.3 0.4
Frequency of depressed mood in last 2 weeks 2.4 3.4 4.7 -1.9 -1.4 2.2
Hearing difficulty/problems: Yes 0.3 0.5 0.9 0.6 0.9 -0.5
Relative age of first facial hair 0.1 0.1 0.3 -0.3 -0.1 0.5
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 2.4 0.8 1.5 -0.7
Ever used hormone-replacement therapy (HRT) 0.9 1.1 2.3 0.7 1.5 -0.8
Ever had hysterectomy (womb removed) 0.1 0.1 0.2 0.1 0.4 -0.0
Systolic blood pressure, automated reading 1.5 4.3 7.8 1.6 2.8 -1.6
Eye problems/disorders: Diabetes related eye disease 0.3 0.3 0.4 0.6 0.5 -0.4
Angina 1.0 1.3 1.8 1.3 0.6 -1.3
Medication for hormone replacement therapy 0.6 0.7 0.8 0.7 0.9 -0.9
Vitamin and mineral supplements 0.3 0.4 0.5 -0.7 -0.6 0.5
Supplements: Zinc 0.3 0.3 0.6 0.5 0.4 -0.8
Medication: Co-codamol 1.6 1.9 2.7 1.2 1.6 -1.2
Medication: Metformin 1.3 1.8 2.2 1.5 1.4 -1.1
Diabetes (father) 0.1 0.2 0.3 -0.1 0.5 0.4
Diabetes (mother) 0.2 0.3 0.6 0.3 -0.2 -0.8
Severe depression (siblings) 0.4 0.5 0.7 0.7 0.8 -0.6
Pack years adult smoking proportion 0.0 0.1 0.1 0.3 0.2 -0.3
Impedance of leg (right) 0.6 3.0 3.8 -1.9 -1.5 1.7
Leg fat-free mass (left) 0.3 1.4 1.8 -0.7 -1.3 1.3
Trunk fat percentage 0.4 1.8 2.2 -1.2 -1.3 1.5
Hand grip strength (right) 0.1 0.2 0.4 0.6 -0.0 -0.5
Townsend deprivation index at recruitment 2.0 2.8 3.7 1.5 1.9 -1.6
Current tobacco smoking 0.2 0.3 0.7 0.2 0.8 -0.1
Average weekly fortified wine intake 1.2 1.4 1.5 -1.1 -1.2 1.2
Maternal smoking around birth 0.0 0.1 0.2 0.1 0.4 0.0
Fed-up feelings 0.5 0.9 1.0 -0.9 -1.0 0.9
Frequency of unenthusiasm / disinterest in last 2 weeks 2.3 3.1 3.6 -1.9 -1.6 1.8
Relative age voice broke 0.1 0.1 0.2 -0.3 -0.2 0.4
Taking other prescription medications 0.0 0.0 0.0 -0.0 -0.0 0.0
Age when periods started (menarche) 0.2 0.6 0.9 0.9 0.3 -1.0
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.2 0.4 0.2 -0.4
Heel bone mineral density (BMD) T-score, automated (left) 2.8 6.4 7.1 2.6 2.3 -2.7
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.4 0.2 0.6 -0.3
Qualifications: CSEs or equivalent 2.8 3.7 3.8 -1.9 -1.8 1.9
Serious illness, injury or assault to yourself 0.1 0.1 0.2 0.3 0.1 -0.5
High blood pressure 1.2 3.5 5.6 1.6 2.4 -1.5
Hayfever, allergic rhinitis or eczema 0.0 0.1 0.1 -0.1 -0.2 0.4
Multivitamins +/- minerals 0.7 0.8 1.1 1.1 0.6 -1.0
Stomach or abdominal pain in last month 0.2 0.2 0.3 0.2 0.6 -0.5
Supplements: Glucosamine 1.1 1.4 2.3 -1.0 -0.9 1.5
Diverticular disease/diverticulitis (self-reported) 0.0 0.0 0.0 0.2 0.1 -0.1
Medication: Atenolol 0.3 0.4 0.6 0.6 0.7 -0.6
Medication: Levothyroxine sodium 0.1 0.1 0.2 0.3 0.4 -0.0
Sitting height 3.3 23.7 33.3 -4.0 -4.7 5.8
Chronic bronchitis/emphysema (father) 2.4 2.8 4.2 1.4 2.0 -1.5
High blood pressure (mother) 2.7 3.8 4.9 2.2 1.8 -1.8
Body mass index (BMI) 0.4 1.8 2.1 1.4 1.2 -1.4
Impedance of leg (left) 0.6 3.0 3.7 -1.9 -1.6 1.7
Leg predicted mass (left) 0.3 1.4 2.0 -0.7 -1.4 1.3
Trunk fat mass 0.5 2.2 2.7 -1.2 -1.5 1.6
Waist circumference 0.1 0.4 0.7 -0.4 -0.8 0.4
Number of incorrect matches in round 0.2 0.4 0.7 0.4 0.9 -0.5
Past tobacco smoking 0.1 0.3 0.5 0.5 0.3 -0.7
Alcohol usually taken with meals 0.7 1.1 1.2 1.0 1.0 -1.1
Nervous feelings 2.6 4.9 5.5 -2.3 -2.0 2.3
Frequency of tenseness / restlessness in last 2 weeks 2.7 4.2 5.2 -2.2 -1.6 2.3
Hearing difficulty/problems with background noise 0.6 1.0 1.8 -1.1 -0.2 1.4
Hair/balding pattern: Pattern 2 0.3 0.4 1.0 -0.1 -1.0 -0.3
Had menopause 0.0 0.0 0.1 0.1 0.3 0.1
Had other major operations 0.7 0.9 1.1 0.8 1.1 -1.0
Forced vital capacity (FVC) 0.2 0.7 1.7 1.3 0.3 -0.6
Heel bone mineral density (BMD) T-score, automated (right) 0.8 1.8 2.1 1.4 1.1 -1.5
Ever unenthusiastic/disinterested for a whole week 0.4 0.5 1.2 -1.1 -0.3 0.4
Qualifications: None of the above 0.3 0.7 1.8 0.3 1.4 -0.2
Financial difficulties in last 2 years 1.4 1.9 2.6 -1.6 -0.8 1.5
Mouth/teeth dental problems 0.1 0.2 0.4 0.3 -0.7 -0.2
Heart attack 0.0 0.1 0.1 0.3 -0.1 -0.2
Allergy 0.1 0.2 0.4 0.4 0.4 -0.6
Pain all over the body in last month 0.2 0.2 0.5 -0.1 0.7 -0.1
Diabetes (self-reported) 0.0 0.1 0.2 0.4 0.2 -0.1
Hayfever/allergic rhinitis (self-reported) 0.2 0.2 0.5 -0.2 -0.7 0.3
Medication: Ramipril 0.3 0.3 0.4 0.6 0.5 -0.7
Medication: Simvastatin 0.6 0.9 1.4 0.8 1.2 -0.8
Fluid intelligence score 3.3 6.8 8.5 -2.4 -2.9 2.4
Illnesses of siblings 1.4 2.0 2.3 -1.4 -1.5 1.2
Neuroticism score 1.0 2.2 3.0 -1.6 -0.9 1.7
Weight 0.2 1.1 1.5 -0.7 -1.1 1.2
Impedance of arm (right) 2.0 9.3 10.8 -3.1 -2.6 3.3
Arm fat percentage (right) 0.0 0.0 0.0 0.0 -0.1 0.1
Trunk fat-free mass 0.1 0.6 1.1 -0.2 -1.1 0.8
Hip circumference 0.3 1.3 2.1 -0.8 -1.1 1.4
Time employed in main current job 5.1 5.9 7.0 -2.6 -2.0 2.7
Alcohol intake versus 10 years previously 0.7 1.0 1.2 1.0 1.1 -0.9
Father’s age at death 0.9 1.2 1.8 -1.0 -1.3 0.9
Worrier / anxious feelings 0.0 0.0 0.0 0.1 0.2 0.2
Frequency of tiredness / lethargy in last 2 weeks 0.3 0.6 0.9 -0.8 -0.3 0.9
Falls in the last year 0.3 0.4 0.6 -0.8 -0.3 0.8
Hair/balding pattern: Pattern 3 0.8 1.2 2.3 -0.9 -0.7 1.5
Number of live births 0.4 0.5 0.8 -0.8 -0.5 0.9
Forced expiratory volume in 1-second (FEV1) 1.3 4.2 6.9 2.6 0.8 -2.2
Pulse rate 0.3 0.5 0.8 -0.7 -0.9 0.5
Happiness 1.9 2.3 3.1 -1.6 -1.1 1.8
Noisy workplace 0.5 0.6 0.7 -0.8 -0.7 0.8
Qualifications: A levels/AS levels or equivalent 0.8 1.9 2.6 -1.3 -1.6 1.2
Serious illness, injury or assault of a close relative in last 2 years 1.7 1.9 2.7 -1.6 -0.8 1.6
Mouth/teeth dental problems: Dentures 1.1 1.9 2.9 1.2 1.7 -1.2
Asthma 1.8 3.6 4.0 -2.0 -1.8 1.8
Medication: Ibuprofen (e.g. Nurofen) 0.9 1.2 1.9 1.0 1.4 -0.8
Medication: Cholesterol lowering 3.0 4.7 5.7 2.1 2.0 -2.4
Depression (self-reported) 2.5 3.0 3.4 -1.7 -1.7 1.9
Medication: Lansoprazole 0.0 0.0 0.1 -0.0 -0.2 -0.1
Prospective memory result 10.2 12.6 13.7 3.4 3.7 -3.5
Lung cancer (father) 1.1 1.2 1.6 -1.3 -0.8 1.2
Illnesses of mother 0.4 0.4 0.8 -0.9 -0.4 0.6
Forced expiratory volume in 1-second (FEV1), Best measure 1.4 4.3 7.1 2.7 1.0 -2.2
Pulse wave Arterial Stiffness index 0.1 0.2 0.4 0.2 -0.3 -0.6
Impedance of arm (left) 2.2 10.4 12.1 -3.3 -2.8 3.5
Arm fat mass (right) 0.0 0.0 0.1 0.1 -0.2 0.2
Trunk predicted mass 0.1 0.7 1.2 -0.3 -1.1 0.9
Standing height 2.7 26.8 32.8 -4.7 -5.1 5.7
Length of working week for main job 0.5 0.6 0.8 0.6 0.9 -0.7
Exposure to tobacco smoke at home 0.6 0.6 0.7 -0.8 -0.9 0.8
Breastfed as a baby 0.1 0.2 0.5 -0.1 -0.7 0.1
Tense / ‘highly strung’ 0.6 0.9 1.1 -1.0 -0.9 1.0
Seen doctor (GP) for nerves, anxiety, tension or depression 0.1 0.2 0.3 -0.4 -0.0 0.6
Hair/balding pattern: Pattern 4 0.7 1.7 2.0 1.4 1.4 -1.2
Birth weight of first child 2.2 4.0 5.5 -1.8 -2.3 1.9
Peak expiratory flow (PEF) 1.6 3.7 5.2 2.3 1.3 -2.0
Pulse wave reflection index 0.0 0.0 0.0 0.1 -0.2 -0.2
Ever highly irritable/argumentative for 2 days 0.4 0.5 1.0 0.6 1.0 -0.3
Loud music exposure frequency 0.1 0.1 0.2 -0.4 -0.3 0.3
Qualifications: O levels/GCSEs or equivalent 0.7 1.1 2.5 -0.8 -1.6 0.4
Mouth/teeth dental problems: Bleeding gums 1.9 2.4 2.8 -1.7 -1.4 1.6
Blood clot in the leg (DVT) 0.1 0.1 0.2 -0.4 -0.0 0.3
Medication: Paracetamol 0.2 0.3 0.6 -0.6 -0.1 0.8
Headache pain in last month 0.3 0.6 1.2 0.5 1.1 -0.5
Medication for cholesterol, blood pressure or diabetes 0.9 1.5 1.7 -1.1 -1.2 1.3
Glaucoma (self-reported) 0.2 0.2 0.3 0.4 0.2 -0.5
Gout (self-reported) 0.1 0.2 0.5 -0.1 -0.7 0.1
Hypothyroidism/myxoedema (self-reported) 0.3 0.6 1.0 0.7 1.0 -0.7
Medication: Amlodipine 0.9 1.3 2.3 0.8 1.5 -1.0
Medication: Ventolin 100micrograms inhaler 0.4 0.5 1.0 -0.5 -1.0 0.6
Birth weight 0.2 0.5 0.7 0.7 0.6 -0.9
Chronic bronchitis/emphysema (mother) 1.1 1.3 1.5 -1.0 -1.2 1.2
High blood pressure (siblings) 1.3 1.8 3.3 1.1 1.8 -1.0
Forced vital capacity (FVC), Best measure 0.4 1.5 2.7 1.7 0.8 -1.0
Body fat percentage 0.1 0.4 0.6 -0.6 -0.6 0.8
Leg fat percentage (right) 0.2 0.7 0.7 0.8 0.8 -0.8
Arm fat-free mass (right) 0.1 0.5 0.9 -0.2 -1.0 0.7
Exposure to tobacco smoke outside home 1.1 1.5 2.3 1.1 1.5 -1.1
Comparative body size at age 10 0.6 1.6 1.8 1.3 1.4 -1.1
Number of full brothers 0.3 0.3 0.7 0.8 -0.0 -0.6
Worry too long after embarrassment 1.5 2.6 2.9 -1.6 -1.5 1.7
Seen a psychiatrist for nerves, anxiety, tension or depression 1.6 2.0 2.5 -1.4 -1.6 1.3
Wheeze or whistling in the chest in last year 0.3 0.6 1.2 -0.8 0.2 1.1
Number of children fathered 0.3 0.3 0.6 -0.6 -0.1 0.8
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.5 -0.6 -0.7 0.5
Age at first live birth 1.8 3.2 4.0 -1.7 -1.7 2.0
Pulse wave peak to peak time 0.3 0.3 0.8 -0.4 -0.0 0.9
Health satisfaction 3.9 5.1 6.2 -2.5 -1.8 2.4
Shortness of breath walking on level ground 0.8 1.0 1.8 -1.1 -0.3 1.3
Qualifications: College or University degree 1.1 3.3 4.5 1.8 2.1 -1.6
Eye problems/disorders: None of the above 0.5 0.6 1.2 0.7 0.4 -1.1
Mouth/teeth dental problems: Loose teeth 0.2 0.2 0.3 -0.5 -0.1 0.5
Emphysema/chronic bronchitis 0.2 0.3 0.7 -0.1 0.9 0.1
Medication for pain relief, constipation, heartburn 0.7 1.2 2.8 -0.7 -1.7 0.7
Neck or shoulder pain in last month 1.2 1.8 2.4 1.1 1.5 -1.3
Medication: Blood pressure 1.0 1.8 2.3 1.2 1.5 -1.3
Angina (self-reported) 0.7 1.0 1.4 1.1 0.5 -1.2
Migraine (self-reported) 0.8 1.0 1.5 0.9 0.8 -1.2
Medication: Ibuprofen 3.9 4.6 5.2 2.1 2.3 -2.0
Medication: Allopurinol 0.1 0.1 0.3 0.3 -0.5 -0.2
Medication: Omeprazole 0.1 0.1 0.2 0.1 0.3 -0.5
Medication: Seretide 50 evohaler 9.4 10.9 12.5 -3.5 -2.8 3.5
Mean time to correctly identify matches 5.4 10.4 13.2 3.3 2.6 -3.6
Heart disease (mother) 4.0 4.9 6.0 2.4 2.1 -2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.6 0.7 1.0 -0.9 -0.7 1.0
Whole body fat mass 0.2 0.8 1.1 -0.7 -0.8 1.1
Leg fat mass (right) 0.0 0.0 0.1 -0.0 -0.3 0.3
Arm predicted mass (right) 0.1 0.5 0.9 -0.2 -1.0 0.7
Pulse rate, automated reading 1.1 3.6 4.1 -1.9 -1.7 2.0
Alcohol intake frequency. 0.4 1.0 1.1 1.0 0.9 -1.1
Comparative height size at age 10 2.3 12.7 14.3 -3.2 -3.8 3.7
Number of full sisters 5.0 6.1 6.5 2.5 2.5 -2.3
Suffer from ‘nerves’ 1.4 2.2 2.4 -1.5 -1.4 1.6
Overall health rating 0.1 0.3 0.3 -0.5 0.6 0.4
Chest pain or discomfort 0.2 0.2 0.5 -0.7 -0.0 0.4
Had major operations 0.3 0.3 0.7 -0.9 -0.2 0.5
Age at last live birth 0.8 1.1 1.5 -1.0 -0.9 1.2
Family relationship satisfaction 0.1 0.1 0.2 -0.4 -0.3 -0.1
Leg pain on walking 2.1 2.7 3.3 -1.7 -1.4 1.8
Qualifications: NVQ or HND or HNC or equivalent 0.0 0.0 0.1 0.1 -0.2 -0.3
Commuting to job workplace: Car/motor vehicle 0.2 0.3 0.4 -0.6 -0.5 0.4
Illness, injury, bereavement, stress in last 2 years 0.9 1.1 1.6 1.1 0.6 -1.3
Medication: Aspirin 0.2 0.3 0.6 0.3 0.8 -0.5
Supplements: Vitamin C 0.3 0.4 0.7 -0.5 -0.4 0.8
Knee pain experienced in last month 0.5 0.7 1.1 0.9 1.0 -0.7
Hypertension (Self-reported) 1.0 2.9 4.9 1.4 2.2 -1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 2.8 3.3 4.2 1.8 1.6 -2.1
Illnesses of father: Heart disease 1.4 1.9 3.7 1.2 0.7 -1.9
Illnesses of siblings: Diabetes 0.4 0.4 0.6 -0.7 -0.8 0.5
Smoking status: Previous 0.3 0.5 0.8 -0.7 -0.4 0.9
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.8 1.3 -0.8 -0.7 1.1
Whole body fat-free mass 0.1 0.8 1.3 -0.4 -1.2 1.0
Leg fat-free mass (right) 0.3 1.4 2.1 -0.7 -1.4 1.3
Arm fat percentage (left) 0.0 0.0 0.0 0.1 -0.1 0.1
Average weekly red wine intake 0.1 0.2 0.4 0.6 0.2 -0.2
Handedness (chirality/laterality): Left-handed 0.3 0.4 0.6 0.8 -0.1 -0.8
Mood swings 1.2 2.2 3.1 -1.7 -0.9 1.8
Loneliness, isolation 4.2 5.8 6.7 -2.6 -2.2 2.4
Long-standing illness, disability or infirmity 0.4 0.7 1.8 0.4 1.3 -0.2
Ever had bowel cancer screening 2.7 3.2 3.4 1.8 1.7 -1.8
Diabetes diagnosed by doctor 0.2 0.3 0.4 0.6 0.6 -0.3
Ever had stillbirth, spontaneous miscarriage or termination 1.0 1.0 1.6 1.3 0.6 -1.1
Friendships satisfaction 0.1 0.2 0.2 0.3 0.5 -0.5
Qualifications: nursing, teaching 0.7 1.0 1.7 1.1 0.5 -1.3
Commuting to job workplace: Walk 0.7 0.8 1.0 0.9 0.6 -1.0
Eye problems/disorders: Cataract 0.3 0.4 0.8 0.2 0.9 0.4
Mouth/teeth dental problems: Mouth ulcers 0.5 0.7 1.7 0.7 1.3 -0.2
Medication for cholesterol 1.6 2.5 4.1 -1.3 -2.0 1.3
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.5 0.6 0.9 -1.0 -0.5 0.8
Back pain experienced in last month 0.1 0.1 0.2 -0.1 0.1 0.5
Mineral and other dietary supplements 0.2 0.3 0.9 0.2 -0.1 -0.9
Breast cancer (self-reported) 0.0 0.0 0.0 -0.2 0.1 0.1
Asthma (self-reported) 1.6 3.3 3.6 -1.9 -1.8 1.7
Osteoporosis (self-reported) 0.5 0.6 0.9 -0.9 -0.7 0.7
Osteoarthritis (self-reported) 0.9 1.1 1.4 1.2 1.1 -0.9
Medication: Aspirin 0.1 0.1 0.2 -0.0 0.5 -0.2
Medication: Gliclazide 0.4 0.4 0.5 -0.6 -0.7 0.7
Illnesses of father: None of the above (group 1) 5.0 6.2 8.0 -2.2 -2.4 2.8
Smoking status: Current 0.2 0.3 0.7 0.3 0.8 -0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage 6.9 14.6 16.2 4.0 3.5 -4.0
Whole body water mass 0.1 0.6 1.0 -0.3 -1.0 0.8
Leg predicted mass (right) 0.3 1.6 2.3 -0.8 -1.5 1.4
Arm fat mass (left) 0.0 0.1 0.2 0.0 -0.4 0.3
Number of self-reported non-cancer illnesses 0.4 0.6 0.8 0.8 0.7 -0.9
Average weekly champagne plus white wine intake 0.7 1.0 2.0 -0.7 -1.4 0.8
Miserableness 2.1 3.7 5.1 -2.0 -1.4 2.3
Guilty feelings 2.5 3.7 4.7 -2.0 -1.6 2.2
Wears glasses or contact lenses 0.1 0.1 0.2 0.2 0.4 -0.1
Ever taken oral contraceptive pill 0.2 0.2 0.3 0.5 0.5 -0.3
Hearing aid user 0.4 0.4 0.5 0.7 0.4 -0.7
Mother’s age at death 0.5 0.7 1.4 -0.6 -1.2 0.4
Financial situation satisfaction 2.7 3.3 3.5 -1.8 -1.8 1.9
Tinnitus: Yes, now most or all of the time 0.2 0.3 0.5 0.5 -0.0 -0.7
Commuting to job workplace: Public transport 0.4 0.5 1.0 0.7 -0.2 -1.0
Eye problems/disorders: Glaucoma 0.2 0.2 0.4 -0.3 -0.6 0.3
Medication: Blood pressure 0.7 1.4 1.7 1.1 1.3 -1.1
Pain type(s) experienced in last month: Hip pain 0.8 1.0 1.6 1.2 1.0 -0.7
Supplements: Fish oil (including cod liver oil) 0.1 0.2 0.3 0.1 0.6 0.4
High cholesterol (Self-reported) 1.7 3.0 3.6 1.7 1.5 -1.9
Medication: Bendroflumethiazide 0.4 0.7 1.7 0.4 1.3 -0.4
Medication: Paracetamol 0.1 0.1 0.3 0.3 0.6 0.0
Medication: Lisinopril 0.1 0.1 0.2 -0.2 0.3 0.4
Medication: Atorvastatin 1.8 2.2 2.8 1.5 1.2 -1.7
Illnesses of father: High blood pressure 1.3 1.6 1.8 1.2 1.3 -1.3
Alcohol drinker status: Never 1.6 2.0 2.9 1.3 1.7 -1.2
Ever smoked 0.2 0.3 0.4 -0.6 -0.5 0.6
Basal metabolic rate 0.1 0.5 0.9 -0.2 -0.9 0.8
Leg fat percentage (left) 0.4 1.3 1.4 1.2 1.1 -1.2
Arm fat-free mass (left) 0.1 0.3 0.6 -0.1 -0.8 0.5
Number of operations (self-reported) 0.9 1.3 2.3 0.8 1.5 -1.0
Average weekly beer plus cider intake 0.7 1.0 1.7 0.6 1.3 -1.0
Irritability 0.3 0.5 1.0 -1.0 -0.2 0.8
Risk taking 6.2 9.1 9.8 3.1 3.1 -2.8
Ever had prostate specific antigen (PSA) test 0.1 0.1 0.3 -0.4 0.0 0.5
Fractured/broken bones in last 5 years 0.2 0.2 0.3 -0.5 -0.2 0.6
Age started oral contraceptive pill 1.2 1.6 1.6 -1.3 -1.2 1.2
Diastolic blood pressure, automated reading 3.1 9.8 10.3 3.2 3.1 -3.1
Ever depressed for a whole week 0.1 0.1 0.3 -0.1 0.2 -0.5
Unable to work because of sickness or disability 0.7 0.9 1.0 -1.0 -0.9 1.0
Commuting to job workplace: Cycle 1.8 2.1 2.9 -1.5 -1.1 1.7
Myopia 2.0 2.9 3.6 1.7 1.5 -1.9
Vascular/heart problems diagnosed by doctor 1.4 3.8 5.3 -1.7 -2.3 1.8
Cholesterol lowering medication 0.5 0.7 1.6 0.6 1.2 -0.4
Medication: Omeprazole (e.g. Zanprol) 0.3 0.3 0.7 0.4 0.4 -0.8
Pain experienced in last month 0.1 0.2 0.5 -0.0 -0.7 -0.1
Supplements: Calcium 0.1 0.1 0.1 -0.3 -0.0 0.3
Basal cell carcinoma (self-reported) 0.3 0.3 0.5 -0.6 -0.7 0.3
Heart attack/myocardial infarction (self-reported) 0.0 0.0 0.1 0.3 -0.1 -0.2
Deep venous thrombosis (DVT) (self-reported) 0.0 0.0 0.1 -0.2 -0.1 0.2
Heart disease (siblings) 0.9 1.1 1.4 1.2 0.8 -1.1
Alcohol drinker status: Previous 3.2 3.6 4.2 2.0 1.6 -2.0
Pack years of smoking 0.0 0.0 0.1 0.2 0.2 -0.3
Impedance of whole body 1.9 9.7 10.7 -3.3 -2.8 3.3
Leg fat mass (left) 0.0 0.0 0.1 0.2 -0.0 0.0
Arm predicted mass (left) 0.1 0.4 0.9 -0.2 -0.9 0.6