Hub : Genes

ARF4

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Cells Transformed fibroblasts	0.184	0.0530	3.5e-09	0.167	NA	0.128	NA	0.156	1.6e-12	NA	8.1e-10	NA	9.1e-12
2	GTEx	Colon Transverse	0.204	0.0650	1.1e-05	0.101	NA	0.107	NA	0.124	1.5e-05	NA	9.0e-06	NA	1.7e-06
3	ROSMAP	Brain Pre-frontal Cortex	0.120	0.0305	2.8e-16	0.148	0.14	0.146	0.145	0.156	1.6e-18	1.5e-17	2.5e-18	3.7e-18	1.4e-19

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3
Bipolar Disorder (2018)	0.5	0.7	1.1	0.9	0.5	-1.1
Bipolar Disorder or Schizophrenia	0.9	2.2	2.3	1.4	1.5	-1.5
Depressed Affect (Nagel 2018)	2.1	4.5	5.6	-2.3	-1.6	2.4
Depression (Nagel 2018)	2.7	4.1	5.1	-2.3	-1.6	2.2
Intelligence (Savage-Jansen 2018)	1.0	3.1	3.9	-1.7	-1.6	2.0
Neuroticism (Nagel 2018)	1.4	3.3	4.1	-2.0	-1.3	2.0
Schizophrenia (2018)	0.8	1.6	2.3	1.1	1.5	-1.1
Schizophrenia vs Biploar Disorder	0.4	0.5	1.1	0.6	1.0	-0.2
Worry (Nagel 2018)	0.2	0.4	0.4	-0.6	-0.6	0.6
Alzheimer’s Disease (in mother)	1.5	1.7	2.3	-1.5	-1.3	1.1
Alzheimer’s Disease (in father)	0.4	0.5	0.7	-0.8	-0.6	0.6
Alzheimer’s Disease (including proxy)	1.4	2.0	2.9	-1.7	-1.1	1.4
Crohns Disease (2017)	0.9	1.9	4.0	-0.9	-2.0	0.9
Irritable Bowel Disease (IBD)	2.3	5.6	8.6	-2.1	-2.9	1.9
Ulcerative Colitis (UC)	2.0	3.8	5.3	-1.9	-2.3	1.6
Major Depression (MDD)	0.1	0.1	0.4	-0.2	0.6	-0.1
Reaction Time	8.3	15.7	18.3	4.2	3.4	-4.3
Verbal and Numeric Reasoning (VNR)	2.5	6.0	6.7	-2.2	-2.6	2.5
Breast Cancer	0.2	0.4	0.7	-0.6	-0.8	0.5
Ovarian Cancer	0.4	0.5	0.9	-0.8	-0.0	0.9
Prostate Cancer	2.8	3.9	5.3	1.9	2.3	-1.7
Age at First Birth	0.6	0.9	1.1	-1.1	-0.9	0.9
Bipolar Disorder (2011)	0.8	0.8	1.0	-1.0	-1.0	0.7
Body Mass Index (BMI) (2010)	1.7	2.4	3.1	1.7	1.6	-1.3
Coronary Artery Disease (CAD)	1.2	1.4	2.1	1.2	0.9	-1.4
Crohns Disease (2012)	0.3	0.5	0.7	0.5	-0.8	-0.8
Mean Putamen Volume	0.1	0.2	0.4	0.1	-0.6	-0.3
Fasting Glucose	1.2	1.5	1.9	1.4	1.0	-1.3
HbA1C	0.7	0.8	1.0	1.0	0.9	-0.7
HDL Cholesterol	1.4	2.4	3.1	-1.4	-1.5	1.8
LDL Cholesterol	0.2	0.3	0.6	0.6	0.3	-0.8
Lupus	2.2	3.3	4.2	-2.0	-1.5	1.9
Neuroticism (2016)	0.7	1.0	1.5	-1.1	-0.7	1.2
Primary Biliary Cirrhosis	0.1	0.1	0.3	-0.1	0.2	-0.5
Rheumatoid Arthritis	0.7	0.9	2.0	0.7	1.4	-0.5
Schizophrenia (2014)	0.3	0.6	1.2	0.7	1.1	-0.5
Triglycerides	2.8	4.7	5.4	2.1	2.3	-2.1
Type 2 Diabetes (T2D) (2012)	2.7	3.1	3.7	-1.6	-1.9	1.7
Ulcerative Colitis	2.2	3.2	3.7	-1.9	-1.8	1.6
Blood Eosinophil Count	0.5	3.8	6.5	-2.5	-1.3	1.8
Blood Platelet Count	0.1	1.7	3.1	-1.2	1.8	0.7
Blood Red Count	0.1	0.5	1.0	0.7	0.2	-1.0
Blood White Count	2.4	18.0	20.5	-4.5	-3.7	4.4
Heel T-Score	6.9	54.8	59.1	7.7	7.0	-7.5
BMI	0.1	0.6	0.9	0.9	0.7	-0.7
Height	3.7	70.9	84.8	-8.1	-7.8	9.2
Waist Hip Ratio (WHR)	0.2	0.8	1.5	-0.9	-1.2	0.1
Systolic Blood Pressure	1.1	5.7	7.3	2.1	2.7	-2.3
Smoking Status	0.2	0.5	1.0	-0.6	0.2	1.0
Allergy or Eczema	0.3	0.7	0.9	-0.7	-0.9	0.9
Cardiovascular Disease	0.7	2.4	2.7	1.4	1.7	-1.5
Hypothyroidism (self reported)	0.3	0.7	1.3	0.5	1.2	-0.7
Respiratory disease	0.7	1.5	1.7	-1.3	-1.0	1.3
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.5	0.6	0.7	-0.4
Lung FEV1/FVC ratio	4.2	21.2	32.3	5.0	2.6	-5.7
Lung FVC	2.8	14.1	17.1	4.1	3.1	-4.0
Neuroticism	0.7	1.7	2.3	-1.5	-0.8	1.4
Chronotype (morning person)	0.4	0.9	1.4	-0.8	-1.2	0.8
Hair Pigment	0.0	0.5	0.8	-0.8	-0.9	-0.3
Tanning	0.0	0.2	0.4	-0.5	-0.3	0.7
Hand grip strength (left)	0.4	1.0	2.9	-0.1	-1.7	0.2
Number of treatments/medications taken	0.1	0.2	0.2	-0.2	0.4	0.5
Average weekly spirits intake	0.0	0.0	0.0	0.2	0.1	0.1
Sensitivity / hurt feelings	0.0	0.1	0.1	0.1	0.3	0.4
Frequency of depressed mood in last 2 weeks	2.4	3.4	4.7	-1.9	-1.4	2.2
Hearing difficulty/problems: Yes	0.3	0.5	0.9	0.6	0.9	-0.5
Relative age of first facial hair	0.1	0.1	0.3	-0.3	-0.1	0.5
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	2.4	0.8	1.5	-0.7
Ever used hormone-replacement therapy (HRT)	0.9	1.1	2.3	0.7	1.5	-0.8
Ever had hysterectomy (womb removed)	0.1	0.1	0.2	0.1	0.4	-0.0
Systolic blood pressure, automated reading	1.5	4.3	7.8	1.6	2.8	-1.6
Eye problems/disorders: Diabetes related eye disease	0.3	0.3	0.4	0.6	0.5	-0.4
Angina	1.0	1.3	1.8	1.3	0.6	-1.3
Medication for hormone replacement therapy	0.6	0.7	0.8	0.7	0.9	-0.9
Vitamin and mineral supplements	0.3	0.4	0.5	-0.7	-0.6	0.5
Supplements: Zinc	0.3	0.3	0.6	0.5	0.4	-0.8
Medication: Co-codamol	1.6	1.9	2.7	1.2	1.6	-1.2
Medication: Metformin	1.3	1.8	2.2	1.5	1.4	-1.1
Diabetes (father)	0.1	0.2	0.3	-0.1	0.5	0.4
Diabetes (mother)	0.2	0.3	0.6	0.3	-0.2	-0.8
Severe depression (siblings)	0.4	0.5	0.7	0.7	0.8	-0.6
Pack years adult smoking proportion	0.0	0.1	0.1	0.3	0.2	-0.3
Impedance of leg (right)	0.6	3.0	3.8	-1.9	-1.5	1.7
Leg fat-free mass (left)	0.3	1.4	1.8	-0.7	-1.3	1.3
Trunk fat percentage	0.4	1.8	2.2	-1.2	-1.3	1.5
Hand grip strength (right)	0.1	0.2	0.4	0.6	-0.0	-0.5
Townsend deprivation index at recruitment	2.0	2.8	3.7	1.5	1.9	-1.6
Current tobacco smoking	0.2	0.3	0.7	0.2	0.8	-0.1
Average weekly fortified wine intake	1.2	1.4	1.5	-1.1	-1.2	1.2
Maternal smoking around birth	0.0	0.1	0.2	0.1	0.4	0.0
Fed-up feelings	0.5	0.9	1.0	-0.9	-1.0	0.9
Frequency of unenthusiasm / disinterest in last 2 weeks	2.3	3.1	3.6	-1.9	-1.6	1.8
Relative age voice broke	0.1	0.1	0.2	-0.3	-0.2	0.4
Taking other prescription medications	0.0	0.0	0.0	-0.0	-0.0	0.0
Age when periods started (menarche)	0.2	0.6	0.9	0.9	0.3	-1.0
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.2	0.4	0.2	-0.4
Heel bone mineral density (BMD) T-score, automated (left)	2.8	6.4	7.1	2.6	2.3	-2.7
Tinnitus: Yes, but not now, but have in the past	0.2	0.2	0.4	0.2	0.6	-0.3
Qualifications: CSEs or equivalent	2.8	3.7	3.8	-1.9	-1.8	1.9
Serious illness, injury or assault to yourself	0.1	0.1	0.2	0.3	0.1	-0.5
High blood pressure	1.2	3.5	5.6	1.6	2.4	-1.5
Hayfever, allergic rhinitis or eczema	0.0	0.1	0.1	-0.1	-0.2	0.4
Multivitamins +/- minerals	0.7	0.8	1.1	1.1	0.6	-1.0
Stomach or abdominal pain in last month	0.2	0.2	0.3	0.2	0.6	-0.5
Supplements: Glucosamine	1.1	1.4	2.3	-1.0	-0.9	1.5
Diverticular disease/diverticulitis (self-reported)	0.0	0.0	0.0	0.2	0.1	-0.1
Medication: Atenolol	0.3	0.4	0.6	0.6	0.7	-0.6
Medication: Levothyroxine sodium	0.1	0.1	0.2	0.3	0.4	-0.0
Sitting height	3.3	23.7	33.3	-4.0	-4.7	5.8
Chronic bronchitis/emphysema (father)	2.4	2.8	4.2	1.4	2.0	-1.5
High blood pressure (mother)	2.7	3.8	4.9	2.2	1.8	-1.8
Body mass index (BMI)	0.4	1.8	2.1	1.4	1.2	-1.4
Impedance of leg (left)	0.6	3.0	3.7	-1.9	-1.6	1.7
Leg predicted mass (left)	0.3	1.4	2.0	-0.7	-1.4	1.3
Trunk fat mass	0.5	2.2	2.7	-1.2	-1.5	1.6
Waist circumference	0.1	0.4	0.7	-0.4	-0.8	0.4
Number of incorrect matches in round	0.2	0.4	0.7	0.4	0.9	-0.5
Past tobacco smoking	0.1	0.3	0.5	0.5	0.3	-0.7
Alcohol usually taken with meals	0.7	1.1	1.2	1.0	1.0	-1.1
Nervous feelings	2.6	4.9	5.5	-2.3	-2.0	2.3
Frequency of tenseness / restlessness in last 2 weeks	2.7	4.2	5.2	-2.2	-1.6	2.3
Hearing difficulty/problems with background noise	0.6	1.0	1.8	-1.1	-0.2	1.4
Hair/balding pattern: Pattern 2	0.3	0.4	1.0	-0.1	-1.0	-0.3
Had menopause	0.0	0.0	0.1	0.1	0.3	0.1
Had other major operations	0.7	0.9	1.1	0.8	1.1	-1.0
Forced vital capacity (FVC)	0.2	0.7	1.7	1.3	0.3	-0.6
Heel bone mineral density (BMD) T-score, automated (right)	0.8	1.8	2.1	1.4	1.1	-1.5
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.2	-1.1	-0.3	0.4
Qualifications: None of the above	0.3	0.7	1.8	0.3	1.4	-0.2
Financial difficulties in last 2 years	1.4	1.9	2.6	-1.6	-0.8	1.5
Mouth/teeth dental problems	0.1	0.2	0.4	0.3	-0.7	-0.2
Heart attack	0.0	0.1	0.1	0.3	-0.1	-0.2
Allergy	0.1	0.2	0.4	0.4	0.4	-0.6
Pain all over the body in last month	0.2	0.2	0.5	-0.1	0.7	-0.1
Diabetes (self-reported)	0.0	0.1	0.2	0.4	0.2	-0.1
Hayfever/allergic rhinitis (self-reported)	0.2	0.2	0.5	-0.2	-0.7	0.3
Medication: Ramipril	0.3	0.3	0.4	0.6	0.5	-0.7
Medication: Simvastatin	0.6	0.9	1.4	0.8	1.2	-0.8
Fluid intelligence score	3.3	6.8	8.5	-2.4	-2.9	2.4
Illnesses of siblings	1.4	2.0	2.3	-1.4	-1.5	1.2
Neuroticism score	1.0	2.2	3.0	-1.6	-0.9	1.7
Weight	0.2	1.1	1.5	-0.7	-1.1	1.2
Impedance of arm (right)	2.0	9.3	10.8	-3.1	-2.6	3.3
Arm fat percentage (right)	0.0	0.0	0.0	0.0	-0.1	0.1
Trunk fat-free mass	0.1	0.6	1.1	-0.2	-1.1	0.8
Hip circumference	0.3	1.3	2.1	-0.8	-1.1	1.4
Time employed in main current job	5.1	5.9	7.0	-2.6	-2.0	2.7
Alcohol intake versus 10 years previously	0.7	1.0	1.2	1.0	1.1	-0.9
Father’s age at death	0.9	1.2	1.8	-1.0	-1.3	0.9
Worrier / anxious feelings	0.0	0.0	0.0	0.1	0.2	0.2
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	0.9	-0.8	-0.3	0.9
Falls in the last year	0.3	0.4	0.6	-0.8	-0.3	0.8
Hair/balding pattern: Pattern 3	0.8	1.2	2.3	-0.9	-0.7	1.5
Number of live births	0.4	0.5	0.8	-0.8	-0.5	0.9
Forced expiratory volume in 1-second (FEV1)	1.3	4.2	6.9	2.6	0.8	-2.2
Pulse rate	0.3	0.5	0.8	-0.7	-0.9	0.5
Happiness	1.9	2.3	3.1	-1.6	-1.1	1.8
Noisy workplace	0.5	0.6	0.7	-0.8	-0.7	0.8
Qualifications: A levels/AS levels or equivalent	0.8	1.9	2.6	-1.3	-1.6	1.2
Serious illness, injury or assault of a close relative in last 2 years	1.7	1.9	2.7	-1.6	-0.8	1.6
Mouth/teeth dental problems: Dentures	1.1	1.9	2.9	1.2	1.7	-1.2
Asthma	1.8	3.6	4.0	-2.0	-1.8	1.8
Medication: Ibuprofen (e.g. Nurofen)	0.9	1.2	1.9	1.0	1.4	-0.8
Medication: Cholesterol lowering	3.0	4.7	5.7	2.1	2.0	-2.4
Depression (self-reported)	2.5	3.0	3.4	-1.7	-1.7	1.9
Medication: Lansoprazole	0.0	0.0	0.1	-0.0	-0.2	-0.1
Prospective memory result	10.2	12.6	13.7	3.4	3.7	-3.5
Lung cancer (father)	1.1	1.2	1.6	-1.3	-0.8	1.2
Illnesses of mother	0.4	0.4	0.8	-0.9	-0.4	0.6
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.3	7.1	2.7	1.0	-2.2
Pulse wave Arterial Stiffness index	0.1	0.2	0.4	0.2	-0.3	-0.6
Impedance of arm (left)	2.2	10.4	12.1	-3.3	-2.8	3.5
Arm fat mass (right)	0.0	0.0	0.1	0.1	-0.2	0.2
Trunk predicted mass	0.1	0.7	1.2	-0.3	-1.1	0.9
Standing height	2.7	26.8	32.8	-4.7	-5.1	5.7
Length of working week for main job	0.5	0.6	0.8	0.6	0.9	-0.7
Exposure to tobacco smoke at home	0.6	0.6	0.7	-0.8	-0.9	0.8
Breastfed as a baby	0.1	0.2	0.5	-0.1	-0.7	0.1
Tense / ‘highly strung’	0.6	0.9	1.1	-1.0	-0.9	1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.2	0.3	-0.4	-0.0	0.6
Hair/balding pattern: Pattern 4	0.7	1.7	2.0	1.4	1.4	-1.2
Birth weight of first child	2.2	4.0	5.5	-1.8	-2.3	1.9
Peak expiratory flow (PEF)	1.6	3.7	5.2	2.3	1.3	-2.0
Pulse wave reflection index	0.0	0.0	0.0	0.1	-0.2	-0.2
Ever highly irritable/argumentative for 2 days	0.4	0.5	1.0	0.6	1.0	-0.3
Loud music exposure frequency	0.1	0.1	0.2	-0.4	-0.3	0.3
Qualifications: O levels/GCSEs or equivalent	0.7	1.1	2.5	-0.8	-1.6	0.4
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	2.8	-1.7	-1.4	1.6
Blood clot in the leg (DVT)	0.1	0.1	0.2	-0.4	-0.0	0.3
Medication: Paracetamol	0.2	0.3	0.6	-0.6	-0.1	0.8
Headache pain in last month	0.3	0.6	1.2	0.5	1.1	-0.5
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	1.7	-1.1	-1.2	1.3
Glaucoma (self-reported)	0.2	0.2	0.3	0.4	0.2	-0.5
Gout (self-reported)	0.1	0.2	0.5	-0.1	-0.7	0.1
Hypothyroidism/myxoedema (self-reported)	0.3	0.6	1.0	0.7	1.0	-0.7
Medication: Amlodipine	0.9	1.3	2.3	0.8	1.5	-1.0
Medication: Ventolin 100micrograms inhaler	0.4	0.5	1.0	-0.5	-1.0	0.6
Birth weight	0.2	0.5	0.7	0.7	0.6	-0.9
Chronic bronchitis/emphysema (mother)	1.1	1.3	1.5	-1.0	-1.2	1.2
High blood pressure (siblings)	1.3	1.8	3.3	1.1	1.8	-1.0
Forced vital capacity (FVC), Best measure	0.4	1.5	2.7	1.7	0.8	-1.0
Body fat percentage	0.1	0.4	0.6	-0.6	-0.6	0.8
Leg fat percentage (right)	0.2	0.7	0.7	0.8	0.8	-0.8
Arm fat-free mass (right)	0.1	0.5	0.9	-0.2	-1.0	0.7
Exposure to tobacco smoke outside home	1.1	1.5	2.3	1.1	1.5	-1.1
Comparative body size at age 10	0.6	1.6	1.8	1.3	1.4	-1.1
Number of full brothers	0.3	0.3	0.7	0.8	-0.0	-0.6
Worry too long after embarrassment	1.5	2.6	2.9	-1.6	-1.5	1.7
Seen a psychiatrist for nerves, anxiety, tension or depression	1.6	2.0	2.5	-1.4	-1.6	1.3
Wheeze or whistling in the chest in last year	0.3	0.6	1.2	-0.8	0.2	1.1
Number of children fathered	0.3	0.3	0.6	-0.6	-0.1	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.3	0.4	0.5	-0.6	-0.7	0.5
Age at first live birth	1.8	3.2	4.0	-1.7	-1.7	2.0
Pulse wave peak to peak time	0.3	0.3	0.8	-0.4	-0.0	0.9
Health satisfaction	3.9	5.1	6.2	-2.5	-1.8	2.4
Shortness of breath walking on level ground	0.8	1.0	1.8	-1.1	-0.3	1.3
Qualifications: College or University degree	1.1	3.3	4.5	1.8	2.1	-1.6
Eye problems/disorders: None of the above	0.5	0.6	1.2	0.7	0.4	-1.1
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.3	-0.5	-0.1	0.5
Emphysema/chronic bronchitis	0.2	0.3	0.7	-0.1	0.9	0.1
Medication for pain relief, constipation, heartburn	0.7	1.2	2.8	-0.7	-1.7	0.7
Neck or shoulder pain in last month	1.2	1.8	2.4	1.1	1.5	-1.3
Medication: Blood pressure	1.0	1.8	2.3	1.2	1.5	-1.3
Angina (self-reported)	0.7	1.0	1.4	1.1	0.5	-1.2
Migraine (self-reported)	0.8	1.0	1.5	0.9	0.8	-1.2
Medication: Ibuprofen	3.9	4.6	5.2	2.1	2.3	-2.0
Medication: Allopurinol	0.1	0.1	0.3	0.3	-0.5	-0.2
Medication: Omeprazole	0.1	0.1	0.2	0.1	0.3	-0.5
Medication: Seretide 50 evohaler	9.4	10.9	12.5	-3.5	-2.8	3.5
Mean time to correctly identify matches	5.4	10.4	13.2	3.3	2.6	-3.6
Heart disease (mother)	4.0	4.9	6.0	2.4	2.1	-2.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.6	0.7	1.0	-0.9	-0.7	1.0
Whole body fat mass	0.2	0.8	1.1	-0.7	-0.8	1.1
Leg fat mass (right)	0.0	0.0	0.1	-0.0	-0.3	0.3
Arm predicted mass (right)	0.1	0.5	0.9	-0.2	-1.0	0.7
Pulse rate, automated reading	1.1	3.6	4.1	-1.9	-1.7	2.0
Alcohol intake frequency.	0.4	1.0	1.1	1.0	0.9	-1.1
Comparative height size at age 10	2.3	12.7	14.3	-3.2	-3.8	3.7
Number of full sisters	5.0	6.1	6.5	2.5	2.5	-2.3
Suffer from ‘nerves’	1.4	2.2	2.4	-1.5	-1.4	1.6
Overall health rating	0.1	0.3	0.3	-0.5	0.6	0.4
Chest pain or discomfort	0.2	0.2	0.5	-0.7	-0.0	0.4
Had major operations	0.3	0.3	0.7	-0.9	-0.2	0.5
Age at last live birth	0.8	1.1	1.5	-1.0	-0.9	1.2
Family relationship satisfaction	0.1	0.1	0.2	-0.4	-0.3	-0.1
Leg pain on walking	2.1	2.7	3.3	-1.7	-1.4	1.8
Qualifications: NVQ or HND or HNC or equivalent	0.0	0.0	0.1	0.1	-0.2	-0.3
Commuting to job workplace: Car/motor vehicle	0.2	0.3	0.4	-0.6	-0.5	0.4
Illness, injury, bereavement, stress in last 2 years	0.9	1.1	1.6	1.1	0.6	-1.3
Medication: Aspirin	0.2	0.3	0.6	0.3	0.8	-0.5
Supplements: Vitamin C	0.3	0.4	0.7	-0.5	-0.4	0.8
Knee pain experienced in last month	0.5	0.7	1.1	0.9	1.0	-0.7
Hypertension (Self-reported)	1.0	2.9	4.9	1.4	2.2	-1.3
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	2.8	3.3	4.2	1.8	1.6	-2.1
Illnesses of father: Heart disease	1.4	1.9	3.7	1.2	0.7	-1.9
Illnesses of siblings: Diabetes	0.4	0.4	0.6	-0.7	-0.8	0.5
Smoking status: Previous	0.3	0.5	0.8	-0.7	-0.4	0.9
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.8	1.3	-0.8	-0.7	1.1
Whole body fat-free mass	0.1	0.8	1.3	-0.4	-1.2	1.0
Leg fat-free mass (right)	0.3	1.4	2.1	-0.7	-1.4	1.3
Arm fat percentage (left)	0.0	0.0	0.0	0.1	-0.1	0.1
Average weekly red wine intake	0.1	0.2	0.4	0.6	0.2	-0.2
Handedness (chirality/laterality): Left-handed	0.3	0.4	0.6	0.8	-0.1	-0.8
Mood swings	1.2	2.2	3.1	-1.7	-0.9	1.8
Loneliness, isolation	4.2	5.8	6.7	-2.6	-2.2	2.4
Long-standing illness, disability or infirmity	0.4	0.7	1.8	0.4	1.3	-0.2
Ever had bowel cancer screening	2.7	3.2	3.4	1.8	1.7	-1.8
Diabetes diagnosed by doctor	0.2	0.3	0.4	0.6	0.6	-0.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.0	1.6	1.3	0.6	-1.1
Friendships satisfaction	0.1	0.2	0.2	0.3	0.5	-0.5
Qualifications: nursing, teaching	0.7	1.0	1.7	1.1	0.5	-1.3
Commuting to job workplace: Walk	0.7	0.8	1.0	0.9	0.6	-1.0
Eye problems/disorders: Cataract	0.3	0.4	0.8	0.2	0.9	0.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.7	1.7	0.7	1.3	-0.2
Medication for cholesterol	1.6	2.5	4.1	-1.3	-2.0	1.3
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.5	0.6	0.9	-1.0	-0.5	0.8
Back pain experienced in last month	0.1	0.1	0.2	-0.1	0.1	0.5
Mineral and other dietary supplements	0.2	0.3	0.9	0.2	-0.1	-0.9
Breast cancer (self-reported)	0.0	0.0	0.0	-0.2	0.1	0.1
Asthma (self-reported)	1.6	3.3	3.6	-1.9	-1.8	1.7
Osteoporosis (self-reported)	0.5	0.6	0.9	-0.9	-0.7	0.7
Osteoarthritis (self-reported)	0.9	1.1	1.4	1.2	1.1	-0.9
Medication: Aspirin	0.1	0.1	0.2	-0.0	0.5	-0.2
Medication: Gliclazide	0.4	0.4	0.5	-0.6	-0.7	0.7
Illnesses of father: None of the above (group 1)	5.0	6.2	8.0	-2.2	-2.4	2.8
Smoking status: Current	0.2	0.3	0.7	0.3	0.8	-0.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	6.9	14.6	16.2	4.0	3.5	-4.0
Whole body water mass	0.1	0.6	1.0	-0.3	-1.0	0.8
Leg predicted mass (right)	0.3	1.6	2.3	-0.8	-1.5	1.4
Arm fat mass (left)	0.0	0.1	0.2	0.0	-0.4	0.3
Number of self-reported non-cancer illnesses	0.4	0.6	0.8	0.8	0.7	-0.9
Average weekly champagne plus white wine intake	0.7	1.0	2.0	-0.7	-1.4	0.8
Miserableness	2.1	3.7	5.1	-2.0	-1.4	2.3
Guilty feelings	2.5	3.7	4.7	-2.0	-1.6	2.2
Wears glasses or contact lenses	0.1	0.1	0.2	0.2	0.4	-0.1
Ever taken oral contraceptive pill	0.2	0.2	0.3	0.5	0.5	-0.3
Hearing aid user	0.4	0.4	0.5	0.7	0.4	-0.7
Mother’s age at death	0.5	0.7	1.4	-0.6	-1.2	0.4
Financial situation satisfaction	2.7	3.3	3.5	-1.8	-1.8	1.9
Tinnitus: Yes, now most or all of the time	0.2	0.3	0.5	0.5	-0.0	-0.7
Commuting to job workplace: Public transport	0.4	0.5	1.0	0.7	-0.2	-1.0
Eye problems/disorders: Glaucoma	0.2	0.2	0.4	-0.3	-0.6	0.3
Medication: Blood pressure	0.7	1.4	1.7	1.1	1.3	-1.1
Pain type(s) experienced in last month: Hip pain	0.8	1.0	1.6	1.2	1.0	-0.7
Supplements: Fish oil (including cod liver oil)	0.1	0.2	0.3	0.1	0.6	0.4
High cholesterol (Self-reported)	1.7	3.0	3.6	1.7	1.5	-1.9
Medication: Bendroflumethiazide	0.4	0.7	1.7	0.4	1.3	-0.4
Medication: Paracetamol	0.1	0.1	0.3	0.3	0.6	0.0
Medication: Lisinopril	0.1	0.1	0.2	-0.2	0.3	0.4
Medication: Atorvastatin	1.8	2.2	2.8	1.5	1.2	-1.7
Illnesses of father: High blood pressure	1.3	1.6	1.8	1.2	1.3	-1.3
Alcohol drinker status: Never	1.6	2.0	2.9	1.3	1.7	-1.2
Ever smoked	0.2	0.3	0.4	-0.6	-0.5	0.6
Basal metabolic rate	0.1	0.5	0.9	-0.2	-0.9	0.8
Leg fat percentage (left)	0.4	1.3	1.4	1.2	1.1	-1.2
Arm fat-free mass (left)	0.1	0.3	0.6	-0.1	-0.8	0.5
Number of operations (self-reported)	0.9	1.3	2.3	0.8	1.5	-1.0
Average weekly beer plus cider intake	0.7	1.0	1.7	0.6	1.3	-1.0
Irritability	0.3	0.5	1.0	-1.0	-0.2	0.8
Risk taking	6.2	9.1	9.8	3.1	3.1	-2.8
Ever had prostate specific antigen (PSA) test	0.1	0.1	0.3	-0.4	0.0	0.5
Fractured/broken bones in last 5 years	0.2	0.2	0.3	-0.5	-0.2	0.6
Age started oral contraceptive pill	1.2	1.6	1.6	-1.3	-1.2	1.2
Diastolic blood pressure, automated reading	3.1	9.8	10.3	3.2	3.1	-3.1
Ever depressed for a whole week	0.1	0.1	0.3	-0.1	0.2	-0.5
Unable to work because of sickness or disability	0.7	0.9	1.0	-1.0	-0.9	1.0
Commuting to job workplace: Cycle	1.8	2.1	2.9	-1.5	-1.1	1.7
Myopia	2.0	2.9	3.6	1.7	1.5	-1.9
Vascular/heart problems diagnosed by doctor	1.4	3.8	5.3	-1.7	-2.3	1.8
Cholesterol lowering medication	0.5	0.7	1.6	0.6	1.2	-0.4
Medication: Omeprazole (e.g. Zanprol)	0.3	0.3	0.7	0.4	0.4	-0.8
Pain experienced in last month	0.1	0.2	0.5	-0.0	-0.7	-0.1
Supplements: Calcium	0.1	0.1	0.1	-0.3	-0.0	0.3
Basal cell carcinoma (self-reported)	0.3	0.3	0.5	-0.6	-0.7	0.3
Heart attack/myocardial infarction (self-reported)	0.0	0.0	0.1	0.3	-0.1	-0.2
Deep venous thrombosis (DVT) (self-reported)	0.0	0.0	0.1	-0.2	-0.1	0.2
Heart disease (siblings)	0.9	1.1	1.4	1.2	0.8	-1.1
Alcohol drinker status: Previous	3.2	3.6	4.2	2.0	1.6	-2.0
Pack years of smoking	0.0	0.0	0.1	0.2	0.2	-0.3
Impedance of whole body	1.9	9.7	10.7	-3.3	-2.8	3.3
Leg fat mass (left)	0.0	0.0	0.1	0.2	-0.0	0.0
Arm predicted mass (left)	0.1	0.4	0.9	-0.2	-0.9	0.6