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chr4:673,778-4,082,936

Best TWAS P=8.75e-11 · Best GWAS P=2.28e-12 conditioned to NaN

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	FAM53A	0.08	0.05	lasso	6	0.03	6.9e-05	-5.9	-5.8	7.9e-09	-0.54	0.38	0.52	TRUE
2	GTEx	Brain Cortex	TACC3	0.26	0.13	lasso	4	0.17	1.7e-05	-5.0	5.8	4.8e-09	0.51	0.26	0.26	FALSE
3	GTEx	Brain Cortex	CRIPAK	0.34	0.10	lasso	6	0.18	9.5e-06	-3.8	-5.4	7.9e-08	0.03	0.20	0.06	FALSE
4	GTEx	Brain Frontal Cortex BA9	TACC3	0.43	0.22	lasso	7	0.18	2.2e-05	-5.1	5.3	1.1e-07	0.31	0.16	0.25	FALSE
5	GTEx	Brain Hippocampus	CRIPAK	0.48	0.22	lasso	4	0.23	4.0e-06	-4.1	-6.0	1.7e-09	0.00	0.18	0.12	TRUE
6	GTEx	Breast Mammary Tissue (Male)	TMEM129	0.10	0.02	lasso	4	0.04	5.4e-02	-5.1	5.3	1.1e-07	0.32	0.02	0.10	FALSE
7	GTEx	Breast Mammary Tissue (Female)	TMEM129	0.06	0.03	lasso	4	0.02	7.9e-02	-5.1	5.2	1.8e-07	0.27	0.03	0.06	TRUE
8	GTEx	Breast Mammary Tissue (Female)	CRIPAK	0.32	0.17	enet	29	0.26	2.7e-08	-3.6	-5.2	2.2e-07	0.01	0.54	0.02	FALSE
9	GTEx	Colon Transverse	TMEM129	0.23	0.05	lasso	4	0.03	1.8e-02	-5.0	6.5	1.1e-10	0.51	0.08	0.11	TRUE
10	GTEx	Lung	CRIPAK	0.61	0.22	enet	46	0.41	1.1e-33	-3.8	-5.3	1.2e-07	0.01	1.00	0.00	FALSE
11	GTEx	Nerve Tibial	TMEM129	0.31	0.24	enet	13	0.28	5.0e-20	-5.1	5.3	9.1e-08	0.38	1.00	0.00	FALSE
12	GTEx	Nerve Tibial	CRIPAK	0.50	0.11	enet	76	0.38	1.1e-28	-4.1	-5.8	8.9e-09	-0.07	1.00	0.00	FALSE
13	GTEx	Skin Sun Exposed Lower leg	TMEM129	0.22	0.16	lasso	5	0.17	5.5e-14	-5.1	5.2	1.9e-07	0.35	1.00	0.00	FALSE
14	GTEx	Skin Sun Exposed Lower leg	AC016773.1	0.10	0.07	lasso	2	0.04	2.4e-04	-5.9	-5.5	3.4e-08	-0.54	0.45	0.38	FALSE
15	GTEx	Testis	TMEM129	0.22	0.19	lasso	3	0.17	5.1e-08	-5.1	5.1	3.1e-07	0.28	0.96	0.00	FALSE
16	GTEx	Thyroid	TMEM129	0.44	0.31	lasso	7	0.34	1.2e-26	-5.1	6.0	2.2e-09	0.45	1.00	0.00	TRUE
17	GTEx	Thyroid	AC016773.1	0.11	0.07	enet	7	0.06	3.9e-05	-5.0	5.6	1.9e-08	0.52	0.67	0.04	FALSE
18	GTEx	Uterus	GRK4	0.31	0.24	enet	29	0.32	2.5e-07	3.6	-5.3	1.3e-07	-0.01	0.37	0.05	TRUE
19	NTR	Blood	CRIPAK	0.13	0.09	enet	31	0.15	1.5e-46	-3.8	-5.9	2.8e-09	0.00	1.00	0.00	FALSE
20	NTR	Blood	KIAA1530	0.19	0.04	blup	345	0.10	9.1e-32	-3.9	-5.3	1.2e-07	0.08	1.00	0.00	FALSE
21	NTR	Blood	SLBP	0.04	0.02	lasso	5	0.02	2.8e-08	-5.0	5.4	7.8e-08	0.82	0.02	0.98	FALSE
22	NTR	Blood	TACC3	0.05	0.03	lasso	9	0.04	2.7e-13	-5.0	5.5	4.5e-08	0.71	0.54	0.46	FALSE
23	ROSMAP	Brain Pre-frontal Cortex	HGFAC	0.12	0.08	lasso	6	0.07	4.4e-09	6.1	6.5	8.7e-11	0.10	0.00	1.00	TRUE
24	ROSMAP	Brain Pre-frontal Cortex	AC016773.1	0.12	0.06	lasso	3	0.10	3.0e-12	-5.0	5.9	4.0e-09	0.52	1.00	0.00	FALSE
25	YFS	Blood	CRIPAK	0.35	0.27	bslmm	301	0.33	6.0e-112	-4.1	-5.2	2.2e-07	-0.02	1.00	0.00	FALSE
26	The Cancer Genome Atlas	Breast Invasive Carcinoma	CRIPAK	0.22	0.11	blup	28	0.14	5.6e-28	-4.1	-5.2	2.5e-07	0.01	0.00	0.85	FALSE
27	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CRIPAK	0.28	0.16	blup	28	0.19	3.2e-21	-4.1	-5.4	7.9e-08	0.03	0.00	0.85	FALSE
28	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TACC3	0.09	0.08	enet	7	0.11	2.7e-05	-5.0	5.9	4.4e-09	0.52	0.13	0.23	FALSE
29	The Cancer Genome Atlas	Skin Cutaneous Melanoma	CRIPAK	0.57	0.07	enet	9	0.23	6.7e-07	-3.8	-5.3	8.7e-08	0.06	0.00	0.28	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	CRIPAK	0.38	0.22	enet	12	0.25	5.4e-24	-4.1	-5.2	1.5e-07	0.00	0.00	0.85	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	DOK7	0.22	0.10	lasso	3	0.14	9.2e-14	-6.0	-5.4	6.0e-08	-0.01	0.01	0.99	TRUE
32	The Cancer Genome Atlas	Thyroid Carcinoma	TMEM129	0.20	0.21	lasso	5	0.24	3.5e-23	-5.1	5.8	7.8e-09	0.49	1.00	0.00	FALSE