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chr4:121,892,436-124,352,460

Best TWAS P=1.47e-11 · Best GWAS P=1.5e-11 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	ANXA5	0.48	0.37	lasso	5	0.46	7.4e-63	6.1	-6.0	1.9e-09	-0.87	0.08	0.92	FALSE
2	CommonMind	Brain Pre-frontal Cortex	BBS7	0.19	0.21	bslmm	423	0.23	1.8e-27	-5.8	-5.8	5.2e-09	-0.14	0.39	0.61	FALSE
3	CommonMind	Brain Pre-frontal Cortex	KIAA1109	0.09	0.08	bslmm	390	0.08	8.9e-10	4.3	-5.9	4.2e-09	-0.12	0.97	0.03	TRUE
4	GTEx	Adipose Subcutaneous	ANXA5	0.25	0.16	lasso	5	0.19	9.9e-16	6.1	-5.6	2.2e-08	-0.90	0.08	0.92	FALSE
5	GTEx	Adrenal Gland	ANXA5	0.23	0.16	lasso	4	0.15	5.3e-06	5.2	-5.9	3.7e-09	-0.92	0.02	0.97	FALSE
6	GTEx	Artery Aorta	ANXA5	0.23	0.21	lasso	3	0.21	1.3e-11	6.1	-6.5	6.9e-11	-0.97	0.02	0.98	FALSE
7	GTEx	Artery Tibial	ANXA5	0.32	0.22	lasso	8	0.20	1.2e-15	6.1	-6.3	3.2e-10	-0.95	0.07	0.93	FALSE
8	GTEx	Brain Nucleus accumbens basal ganglia	ANXA5	0.46	0.26	lasso	7	0.23	9.9e-07	6.1	-6.5	1.0e-10	-0.97	0.01	0.99	FALSE
9	GTEx	Cells EBV-transformed lymphocytes	EXOSC9	0.29	0.17	lasso	7	0.16	6.6e-06	4.5	5.4	7.7e-08	0.09	0.87	0.02	FALSE
10	GTEx	Cells Transformed fibroblasts	BBS7	0.16	0.09	lasso	7	0.16	2.9e-12	-5.9	-5.9	2.9e-09	-0.14	0.46	0.54	FALSE
11	GTEx	Colon Transverse	BBS12	0.12	0.05	enet	29	0.12	3.2e-06	-1.6	5.4	5.7e-08	0.01	0.03	0.52	FALSE
12	GTEx	Muscle Skeletal	ANXA5	0.20	0.18	enet	5	0.20	3.1e-19	6.7	-6.4	1.3e-10	-0.96	0.00	1.00	FALSE
13	GTEx	Pituitary	ANXA5	0.35	0.36	lasso	4	0.27	1.7e-07	6.1	-6.1	8.7e-10	-0.94	0.03	0.97	FALSE
14	GTEx	Spleen	ANXA5	0.42	0.28	lasso	6	0.23	1.7e-06	6.1	-5.9	3.2e-09	-0.90	0.04	0.91	FALSE
15	GTEx	Testis	EXOSC9	0.17	0.07	lasso	8	0.10	2.5e-05	-4.3	5.6	2.5e-08	0.14	0.58	0.22	FALSE
16	GTEx	Testis	ANXA5	0.43	0.33	lasso	3	0.32	6.3e-15	6.1	-6.2	7.1e-10	-0.93	0.08	0.92	FALSE
17	GTEx	Thyroid	ANXA5	0.29	0.18	lasso	7	0.18	1.6e-13	6.1	-6.1	9.1e-10	-0.93	0.08	0.92	FALSE
18	METSIM	Adipose	ANXA5	0.15	0.14	enet	25	0.15	4.7e-22	6.1	-5.2	1.9e-07	-0.82	0.03	0.97	FALSE
19	ROSMAP	Brain Pre-frontal Cortex	ANXA5	0.48	0.47	lasso	9	0.49	5.3e-72	6.1	-6.1	9.5e-10	-0.92	0.09	0.91	FALSE
20	The Cancer Genome Atlas	Breast Invasive Carcinoma	EXOSC9	0.03	0.04	enet	9	0.04	2.8e-08	4.5	5.5	3.1e-08	0.08	0.59	0.40	FALSE
21	The Cancer Genome Atlas	Glioblastoma Multiforme	ANXA5	0.29	0.07	blup	73	0.12	1.4e-04	6.1	-5.7	9.8e-09	-0.83	0.01	0.92	FALSE
22	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	CCNA2	0.03	0.01	blup	34	0.02	1.5e-03	-5.7	6.3	2.2e-10	0.12	0.00	0.97	TRUE
23	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	BBS7	0.04	0.04	lasso	2	0.03	6.1e-04	-5.8	-5.8	6.5e-09	-0.12	0.00	1.00	FALSE
24	The Cancer Genome Atlas	Brain Lower Grade Glioma	ANXA5	0.22	0.29	lasso	7	0.30	3.9e-34	6.1	-5.6	2.5e-08	-0.88	0.08	0.92	FALSE
25	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EXOSC9	0.03	0.02	lasso	2	0.02	1.0e-03	5.0	5.5	3.9e-08	0.06	0.08	0.35	FALSE
26	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	ANXA5	0.08	0.06	lasso	3	0.06	7.8e-05	6.1	-6.1	1.1e-09	-0.91	0.02	0.94	FALSE
27	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ANXA5	0.23	0.24	lasso	7	0.22	2.7e-09	6.7	-6.8	1.5e-11	-0.99	0.00	1.00	TRUE
28	The Cancer Genome Atlas	Prostate Adenocarcinoma	ANXA5	0.05	0.03	enet	7	0.04	3.3e-05	5.2	-6.1	1.2e-09	-0.88	0.06	0.93	FALSE
29	The Cancer Genome Atlas	Soft Tissue Sarcoma	ANXA5	0.06	0.03	lasso	3	0.03	9.8e-03	6.1	-6.0	1.6e-09	-0.93	0.02	0.81	FALSE
30	The Cancer Genome Atlas	Thyroid Carcinoma	ANXA5	0.14	0.12	lasso	4	0.14	5.6e-14	6.1	-6.2	5.4e-10	-0.89	0.00	1.00	FALSE
31	The Cancer Genome Atlas	Thyroid Carcinoma	EXOSC9	0.04	0.05	lasso	2	0.04	7.1e-05	4.5	5.4	7.1e-08	0.10	0.04	0.94	FALSE