Best TWAS P=7.87e-94 · Best GWAS P=4.56e-105 conditioned to 6.97e-12
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | GYPA | 0.20 | 0.06 | blup | 293 | 0.10 | 4.0e-12 | -1.5 | -5.9 | 3.0e-09 | -0.11 | 1.00 | 0.00 | TRUE |
| 2 | CommonMind | Brain Pre-frontal Cortex | GYPE | 0.28 | 0.26 | bslmm | 263 | 0.35 | 1.0e-44 | -4.8 | 5.1 | 3.0e-07 | 0.01 | 1.00 | 0.00 | TRUE |
| 3 | CommonMind | Brain Pre-frontal Cortex | OTUD4 | 0.06 | 0.04 | bslmm | 272 | 0.04 | 2.6e-05 | -12.0 | -12.0 | 2.5e-33 | -0.37 | 0.82 | 0.06 | FALSE |
| 4 | GTEx | Brain Hypothalamus | HHIP-AS1 | 0.12 | 0.02 | enet | 16 | 0.04 | 4.6e-02 | 16.1 | 13.2 | 4.6e-40 | 0.45 | 0.04 | 0.49 | TRUE |
| 5 | GTEx | Pancreas | ANAPC10 | 0.14 | 0.10 | lasso | 3 | 0.10 | 4.3e-05 | -20.0 | 20.5 | 7.9e-94 | 0.73 | 0.04 | 0.90 | TRUE |
| 6 | ROSMAP | Brain Pre-frontal Cortex | OTUD4 | 0.04 | 0.03 | lasso | 2 | 0.03 | 1.4e-04 | 16.0 | -16.3 | 7.6e-60 | -0.34 | 0.65 | 0.04 | TRUE |
| 7 | The Cancer Genome Atlas | Colon Adenocarcinoma | GYPE | 0.05 | 0.04 | blup | 18 | 0.04 | 3.3e-03 | -5.0 | -5.1 | 3.1e-07 | -0.05 | 0.01 | 0.85 | FALSE |