Best TWAS P=5.13e-15 · Best GWAS P=2.16e-19 conditioned to NaN
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | GHR | 0.25 | 0.07 | bslmm | 382 | 0.13 | 2.6e-15 | -7.011 | 6.9 | 4.0e-12 | -0.61 | 0.02 | 0.98 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | ZNF131 | 0.07 | 0.02 | blup | 349 | 0.02 | 5.7e-04 | -0.039 | 5.5 | 5.2e-08 | -0.54 | 0.16 | 0.67 | FALSE |
| 3 | GTEx | Adipose Subcutaneous | CCDC152 | 0.09 | 0.04 | lasso | 4 | 0.02 | 6.4e-03 | 7.385 | 7.3 | 3.2e-13 | -0.56 | 0.85 | 0.04 | FALSE |
| 4 | GTEx | Adipose Visceral Omentum | CCDC152 | 0.09 | 0.06 | lasso | 9 | 0.05 | 1.9e-03 | 7.256 | 7.1 | 9.6e-13 | -0.59 | 0.16 | 0.14 | TRUE |
| 5 | GTEx | Artery Aorta | CCDC152 | 0.31 | 0.24 | lasso | 8 | 0.24 | 2.5e-13 | 7.256 | 6.2 | 6.6e-10 | -0.44 | 1.00 | 0.00 | FALSE |
| 6 | GTEx | Artery Coronary | CCDC152 | 0.20 | 0.13 | lasso | 2 | 0.12 | 7.7e-05 | 7.256 | 7.3 | 2.5e-13 | -0.58 | 0.63 | 0.11 | FALSE |
| 7 | GTEx | Artery Tibial | CCDC152 | 0.22 | 0.17 | enet | 35 | 0.18 | 1.8e-14 | 7.256 | 6.1 | 1.3e-09 | -0.46 | 1.00 | 0.00 | TRUE |
| 8 | GTEx | Cells Transformed fibroblasts | CTD-2201E18.5 | 0.06 | 0.03 | enet | 10 | 0.03 | 1.2e-03 | -5.486 | -5.3 | 1.0e-07 | 0.38 | 0.52 | 0.18 | TRUE |
| 9 | GTEx | Esophagus Muscularis | CCDC152 | 0.13 | 0.09 | lasso | 8 | 0.10 | 7.9e-07 | 6.835 | 6.4 | 1.9e-10 | -0.45 | 0.96 | 0.00 | FALSE |
| 10 | GTEx | Stomach | SERBP1P6 | 0.12 | 0.03 | enet | 16 | 0.01 | 6.7e-02 | -2.406 | 5.8 | 6.6e-09 | -0.38 | 0.08 | 0.15 | FALSE |
| 11 | GTEx | Thyroid | CCDC152 | 0.10 | 0.07 | lasso | 4 | 0.04 | 4.2e-04 | 7.227 | 7.2 | 4.1e-13 | -0.58 | 0.73 | 0.12 | FALSE |
| 12 | ROSMAP | Brain Pre-frontal Cortex | CCDC152 | 0.20 | 0.09 | lasso | 10 | 0.09 | 5.2e-12 | 2.507 | 5.6 | 2.1e-08 | -0.35 | 1.00 | 0.00 | FALSE |
| 13 | ROSMAP | Brain Pre-frontal Cortex | SEPP1 | 0.18 | 0.19 | lasso | 11 | 0.21 | 1.3e-26 | 6.742 | -7.2 | 8.5e-13 | 0.56 | 1.00 | 0.00 | FALSE |
| 14 | YFS | Blood | CCDC152 | 0.07 | 0.06 | enet | 16 | 0.06 | 2.0e-19 | 7.385 | 7.8 | 5.9e-15 | -0.62 | 1.00 | 0.00 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | SEPP1 | 0.01 | 0.00 | enet | 7 | 0.01 | 1.5e-03 | 7.119 | -6.0 | 1.7e-09 | 0.65 | 0.04 | 0.12 | TRUE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | CCDC152 | 0.06 | 0.06 | blup | 40 | 0.07 | 1.6e-08 | 6.768 | -7.8 | 5.1e-15 | 0.73 | 0.71 | 0.29 | TRUE |
| 17 | The Cancer Genome Atlas | Prostate Adenocarcinoma | CCDC152 | 0.15 | 0.12 | lasso | 6 | 0.12 | 1.0e-12 | 7.119 | -7.2 | 4.8e-13 | 0.58 | 1.00 | 0.00 | FALSE |
| 18 | The Cancer Genome Atlas | Prostate Adenocarcinoma | SEPP1 | 0.06 | 0.02 | blup | 38 | 0.04 | 5.2e-05 | 6.835 | -7.7 | 1.2e-14 | 0.76 | 0.22 | 0.70 | TRUE |