Hub : Genes

GHR

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.2510	0.0540	5.8e-13	0.073	0.102	0.127	0.128	0.123	3.1e-09	2.0e-12	3.1e-15	2.6e-15	8.9e-15
2	GTEx	Brain Frontal Cortex BA9	0.1442	0.0606	1.3e-03	0.020	NA	0.029	NA	0.062	9.5e-02	NA	5.9e-02	NA	9.9e-03
3	GTEx	Thyroid	0.0760	0.0420	7.8e-03	0.039	NA	0.044	NA	0.040	5.7e-04	NA	2.5e-04	NA	4.9e-04
4	ROSMAP	Brain Pre-frontal Cortex	0.0376	0.0169	5.1e-04	0.024	0.032	0.010	0.028	0.024	4.4e-04	5.4e-05	1.6e-02	1.4e-04	4.4e-04
5	TCGA	Prostate Adenocarcinoma	0.1155	0.0433	1.0e-10	0.111	0.111	0.128	NA	0.122	1.3e-11	1.3e-11	2.5e-13	NA	1.1e-12

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Bipolar Disorder (2018)	0.6	0.9	3.2	0.3	-1.8	0.0	-0.1	-1.1
Bipolar Disorder or Schizophrenia	0.3	0.8	2.0	0.3	-1.3	0.2	-0.5	-1.4
Depressed Affect (Nagel 2018)	0.6	1.2	3.2	-1.1	-0.5	-1.8	-1.1	-0.1
Depression (Nagel 2018)	1.2	1.9	4.8	-0.3	-2.2	0.6	-1.0	-1.7
Intelligence (Savage-Jansen 2018)	2.2	6.7	11.4	2.3	3.1	-1.0	3.4	2.5
Neuroticism (Nagel 2018)	0.4	0.9	3.4	0.1	-0.0	-1.8	-0.8	-0.5
Schizophrenia (2018)	0.1	0.3	0.9	0.1	-0.2	0.2	-0.6	-0.9
Schizophrenia vs Biploar Disorder	0.4	0.6	0.8	0.9	0.5	-0.9	0.6	0.9
Worry (Nagel 2018)	0.3	0.5	0.9	0.6	0.7	-0.7	-0.9	-0.6
Alzheimer’s Disease (in mother)	0.3	0.4	0.7	-0.8	0.9	0.1	-0.4	-0.7
Alzheimer’s Disease (in father)	3.0	3.3	8.4	-0.9	-2.9	1.1	-2.2	-1.1
Alzheimer’s Disease (including proxy)	0.7	1.0	2.2	-1.5	-0.5	0.2	-1.4	-0.8
Crohns Disease (2017)	0.5	1.0	2.1	-1.0	-0.4	0.9	-1.1	-1.4
Irritable Bowel Disease (IBD)	0.2	0.5	2.1	-1.4	0.2	0.1	-0.7	0.0
Ulcerative Colitis (UC)	0.8	1.5	2.9	-1.5	1.3	-0.9	0.4	1.7
Major Depression (MDD)	6.5	7.8	11.1	3.1	-3.3	2.5	-2.2	-2.7
Reaction Time	0.1	0.3	0.7	0.0	-0.8	0.6	-0.3	-0.4
Verbal and Numeric Reasoning (VNR)	3.2	7.6	15.0	2.9	3.0	0.6	3.9	2.3
Breast Cancer	1.6	3.8	9.6	0.7	1.3	-0.0	2.7	3.1
Ovarian Cancer	1.3	1.7	6.8	-2.6	-0.3	0.9	-0.5	-0.7
Prostate Cancer	0.2	0.2	0.9	0.0	-0.3	0.1	-1.0	0.5
Age at First Birth	2.8	4.0	6.3	0.5	2.4	-2.5	2.4	1.5
Bipolar Disorder (2011)	0.5	0.5	1.0	-0.5	-1.0	0.2	-0.5	-0.9
Body Mass Index (BMI) (2010)	0.8	1.1	2.4	-0.0	-0.1	1.1	-1.3	-1.6
Coronary Artery Disease (CAD)	0.8	1.0	1.8	-1.4	0.9	-1.3	0.2	0.7
Crohns Disease (2012)	1.1	1.7	4.3	-0.2	-0.7	1.8	-0.5	-2.1
Mean Putamen Volume	0.4	0.5	0.9	-0.8	-0.7	-0.4	-0.9	0.4
Fasting Glucose	1.7	2.1	3.9	-2.0	-0.7	-1.7	-1.5	0.9
HbA1C	1.7	1.9	4.0	-0.1	2.0	-1.8	-0.0	1.4
HDL Cholesterol	0.2	0.3	0.8	0.4	-0.4	-0.5	0.2	0.9
LDL Cholesterol	0.2	0.3	0.8	-0.4	-0.8	0.3	-0.9	0.0
Lupus	1.4	2.1	5.6	-2.4	-0.6	1.0	-1.8	-0.3
Neuroticism (2016)	0.7	0.9	2.1	0.4	-0.5	-1.0	-1.0	1.4
Primary Biliary Cirrhosis	0.6	0.9	2.5	1.2	0.6	-0.2	1.6	-0.5
Rheumatoid Arthritis	0.1	0.2	0.6	-0.1	0.8	-0.0	0.6	0.0
Schizophrenia (2014)	0.2	0.4	0.9	1.0	-0.2	0.5	0.5	-0.5
Triglycerides	0.9	1.5	3.4	-1.9	1.4	-0.7	-0.0	1.3
Type 2 Diabetes (T2D) (2012)	0.1	0.1	0.4	0.0	0.4	-0.6	-0.1	0.4
Ulcerative Colitis	0.7	1.0	2.2	-0.4	1.5	-1.1	1.0	0.8
Blood Eosinophil Count	0.3	2.1	3.9	0.4	-1.5	1.5	-1.4	-2.0
Blood Platelet Count	0.1	1.5	2.8	-0.8	-0.4	1.7	-1.1	-1.7
Blood Red Count	0.4	3.5	5.9	-1.6	1.2	-2.4	1.4	2.3
Blood White Count	0.0	0.4	0.8	-0.7	-0.7	-0.2	-0.9	-0.3
Heel T-Score	7.5	59.6	106.1	0.4	9.4	-6.2	8.0	10.3
BMI	1.1	6.1	11.2	1.4	-3.2	3.3	-2.0	-1.7
Height	2.5	47.3	121.5	11.0	-2.1	2.7	3.0	-9.7
Waist Hip Ratio (WHR)	0.3	1.4	4.4	-2.1	-0.3	-0.3	-0.4	1.5
Systolic Blood Pressure	0.9	4.3	8.7	-0.9	-1.4	1.9	-3.0	-2.5
Smoking Status	0.6	1.5	3.3	0.3	-1.4	-0.6	-1.8	-1.3
Allergy or Eczema	0.4	0.9	2.5	0.9	0.5	0.9	0.5	-1.6
Cardiovascular Disease	0.9	3.1	6.3	-0.5	-1.9	1.2	-2.0	-2.5
Hypothyroidism (self reported)	0.7	1.6	4.8	-0.2	-1.5	2.2	-0.2	-1.0
Respiratory disease	1.9	4.3	7.5	-1.6	-1.9	0.9	-2.6	-2.7
Type 2 Diabetes (T2D) (2018)	0.2	0.4	0.9	0.5	-0.5	1.0	0.7	0.1
Lung FEV1/FVC ratio	1.3	6.7	18.8	-2.3	1.3	-4.3	-0.1	2.8
Lung FVC	0.5	2.5	6.6	1.0	1.3	-1.8	2.6	0.3
Neuroticism	0.4	0.9	3.9	-0.1	0.4	-2.0	-0.2	-0.6
Chronotype (morning person)	1.3	3.1	5.5	-2.1	1.1	-2.3	-0.1	2.0
Hair Pigment	0.1	2.3	3.2	1.2	1.8	-1.3	1.6	1.7
Tanning	0.1	1.2	2.0	1.4	0.6	-0.3	1.3	1.3
Hand grip strength (left)	2.0	5.1	9.4	1.0	-2.4	2.2	-2.2	-3.1
Number of treatments/medications taken	1.0	1.8	3.4	0.1	-1.7	0.5	-1.6	-1.8
Average weekly spirits intake	1.3	1.7	3.2	1.5	-1.8	0.6	-0.9	-1.3
Sensitivity / hurt feelings	0.2	0.3	0.9	0.1	-0.5	-0.7	-0.1	0.9
Frequency of depressed mood in last 2 weeks	0.7	1.0	2.3	-0.4	-0.6	-1.2	-0.9	-1.5
Hearing difficulty/problems: Yes	2.1	3.2	12.2	0.5	1.7	-0.2	3.5	0.9
Relative age of first facial hair	1.0	2.0	4.6	-1.2	0.8	-0.5	-2.1	1.7
Other serious medical condition/disability diagnosed by doctor	0.4	0.6	1.5	-0.2	-0.4	0.2	-1.0	-1.2
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.9	0.5	1.7	-0.2	1.5	0.8
Ever had hysterectomy (womb removed)	1.0	1.1	2.8	1.5	0.4	-0.4	0.3	-1.7
Systolic blood pressure, automated reading	1.0	2.9	5.6	-0.7	-1.8	2.0	-2.4	-1.2
Eye problems/disorders: Diabetes related eye disease	0.6	0.7	2.1	-0.1	1.4	-0.8	0.7	-0.1
Angina	0.3	0.3	0.7	0.6	-0.6	-0.3	0.4	-0.8
Medication for hormone replacement therapy	0.5	0.6	1.3	-0.4	0.9	-1.1	0.5	0.5
Vitamin and mineral supplements	0.5	0.7	2.8	-0.4	0.2	-0.3	0.6	1.7
Supplements: Zinc	0.1	0.2	0.7	0.2	-0.0	0.1	0.9	-0.1
Medication: Co-codamol	0.5	0.6	1.7	-0.5	-0.4	0.0	-0.9	-1.3
Medication: Metformin	0.4	0.6	2.4	0.8	-0.1	0.1	1.6	-0.2
Diabetes (father)	1.4	1.7	4.9	-2.2	-0.2	-1.8	0.3	0.5
Diabetes (mother)	1.0	1.3	4.2	0.4	-1.3	2.0	-0.6	-0.1
Severe depression (siblings)	4.7	5.3	10.1	-0.5	-2.2	1.2	-3.2	-3.1
Pack years adult smoking proportion	0.8	1.2	4.9	-0.4	-0.7	0.5	0.1	2.2
Impedance of leg (right)	2.5	12.0	20.2	-3.1	3.9	-3.4	2.0	4.5
Leg fat-free mass (left)	5.4	28.4	54.8	5.9	-5.1	4.7	-2.2	-7.4
Trunk fat percentage	0.2	0.8	1.8	-0.4	-0.7	0.6	-1.4	1.1
Hand grip strength (right)	2.1	5.6	12.0	0.8	-2.7	1.6	-2.4	-3.5
Townsend deprivation index at recruitment	0.2	0.3	0.6	0.6	-0.8	0.1	-0.8	0.1
Current tobacco smoking	0.4	0.6	2.2	0.2	-1.5	-0.3	-0.6	0.3
Average weekly fortified wine intake	0.3	0.4	1.0	1.0	0.4	-0.1	0.3	-0.9
Maternal smoking around birth	1.1	1.6	2.6	-1.6	1.1	-1.6	-1.2	0.3
Fed-up feelings	0.5	1.0	3.0	-0.9	0.1	-1.7	-1.1	-0.1
Frequency of unenthusiasm / disinterest in last 2 weeks	0.8	1.0	2.2	-0.8	-1.2	-0.0	-0.9	-1.5
Relative age voice broke	0.5	0.7	2.1	0.4	-0.8	0.6	-1.4	0.4
Taking other prescription medications	0.5	0.8	1.6	-1.3	-0.6	-0.1	-0.7	-1.3
Age when periods started (menarche)	0.7	1.7	3.8	-0.8	1.9	-1.0	1.6	0.8
Bilateral oophorectomy (both ovaries removed)	0.3	0.4	1.6	1.3	-0.2	0.2	0.3	0.2
Heel bone mineral density (BMD) T-score, automated (left)	5.5	12.5	24.7	0.8	3.1	-1.9	5.0	4.8
Tinnitus: Yes, but not now, but have in the past	1.0	1.1	2.7	-0.9	-0.9	0.6	-1.6	0.7
Qualifications: CSEs or equivalent	0.5	0.6	1.6	-0.1	1.0	-1.2	-0.4	0.7
Serious illness, injury or assault to yourself	0.7	0.9	3.1	-1.8	-0.5	0.5	-0.3	-0.9
High blood pressure	1.8	5.1	11.0	-0.3	-2.4	2.0	-3.3	-2.1
Hayfever, allergic rhinitis or eczema	0.6	1.4	3.6	1.9	0.1	0.7	0.1	-1.7
Multivitamins +/- minerals	0.7	0.9	2.2	0.4	1.5	-0.3	1.3	-0.0
Stomach or abdominal pain in last month	0.7	0.8	1.9	-0.0	1.0	1.4	1.1	-0.3
Supplements: Glucosamine	2.9	3.8	8.5	0.0	2.9	-0.4	2.0	2.5
Diverticular disease/diverticulitis (self-reported)	0.8	1.0	2.1	-0.1	1.4	0.6	0.7	1.4
Medication: Atenolol	0.2	0.3	0.5	0.7	-0.5	0.4	0.2	0.7
Medication: Levothyroxine sodium	1.8	3.1	4.6	-2.0	-2.1	2.0	-1.2	-1.2
Sitting height	1.9	13.7	48.2	6.9	0.6	2.3	3.1	-2.2
Chronic bronchitis/emphysema (father)	0.9	1.1	3.0	-0.1	0.3	-0.2	1.7	1.5
High blood pressure (mother)	3.8	5.4	9.9	-1.2	-2.8	1.7	-3.1	-2.2
Body mass index (BMI)	1.4	5.8	13.5	0.6	-3.7	2.3	-2.7	-1.6
Impedance of leg (left)	2.4	11.7	16.8	-3.4	4.0	-3.2	2.0	4.1
Leg predicted mass (left)	5.3	28.0	54.6	5.9	-5.0	4.6	-2.1	-7.4
Trunk fat mass	0.7	2.8	4.4	1.6	-2.1	1.9	-1.4	-1.2
Waist circumference	0.7	2.6	5.4	0.7	-2.3	1.7	-1.4	-1.5
Number of incorrect matches in round	1.1	1.8	4.4	-1.5	-0.6	-1.4	-2.1	-0.1
Past tobacco smoking	1.0	1.9	2.8	-0.9	1.4	1.4	1.7	1.3
Alcohol usually taken with meals	0.6	1.0	3.0	-0.5	0.9	0.8	1.7	-0.4
Nervous feelings	0.9	1.7	5.3	0.1	2.3	-1.7	-0.7	-0.3
Frequency of tenseness / restlessness in last 2 weeks	1.6	2.5	4.9	-1.6	-1.3	-0.9	-1.7	-2.2
Hearing difficulty/problems with background noise	0.9	1.4	4.0	0.4	1.6	-0.6	2.0	-0.4
Hair/balding pattern: Pattern 2	1.0	1.3	2.8	-1.2	1.7	-1.4	-0.1	0.7
Had menopause	1.4	1.8	5.2	-1.3	1.2	0.7	2.3	0.4
Had other major operations	1.3	1.6	3.7	0.8	-1.9	1.4	-1.0	-0.8
Forced vital capacity (FVC)	1.5	5.7	12.8	3.6	-0.8	0.3	1.4	-3.6
Heel bone mineral density (BMD) T-score, automated (right)	5.8	13.3	31.7	0.3	3.4	-1.7	4.5	5.6
Ever unenthusiastic/disinterested for a whole week	0.5	0.6	2.0	-0.4	0.4	-0.6	-0.5	-1.4
Qualifications: None of the above	0.4	0.8	1.1	-1.0	-0.9	-0.5	-0.9	-1.0
Financial difficulties in last 2 years	1.4	1.9	5.7	-1.2	-1.2	-0.0	-2.4	-0.8
Mouth/teeth dental problems	0.2	0.3	1.0	0.2	1.0	-0.1	-0.5	-0.5
Heart attack	2.8	3.6	9.8	0.6	2.2	-3.1	1.7	0.7
Allergy	0.3	0.7	1.8	-1.1	-0.1	-0.0	0.6	1.4
Pain all over the body in last month	0.3	0.3	0.9	0.5	0.1	0.6	0.2	1.0
Diabetes (self-reported)	0.2	0.3	0.6	0.8	-0.6	0.1	0.8	0.4
Hayfever/allergic rhinitis (self-reported)	0.6	0.8	2.5	0.6	-0.8	0.4	0.3	-1.6
Medication: Ramipril	0.4	0.5	1.8	0.4	-0.2	0.8	-1.3	-0.3
Medication: Simvastatin	0.2	0.3	0.9	-0.4	-0.3	-0.4	-1.0	-0.6
Fluid intelligence score	0.9	1.8	3.2	0.8	1.1	1.8	1.5	1.2
Illnesses of siblings	1.9	2.7	5.6	-1.2	1.4	0.4	2.1	2.4
Neuroticism score	0.2	0.5	1.8	0.2	0.3	-1.3	-0.6	-0.3
Weight	3.1	15.4	24.3	3.9	-4.5	3.8	-1.8	-4.9
Impedance of arm (right)	3.7	17.4	32.9	-2.2	5.7	-3.8	2.2	5.5
Arm fat percentage (right)	0.4	1.5	3.3	-0.0	-1.5	1.1	-1.8	0.9
Trunk fat-free mass	6.6	37.8	76.5	7.3	-5.7	5.1	-1.3	-8.7
Hip circumference	1.2	5.4	10.0	3.0	-1.9	1.8	-0.8	-3.2
Time employed in main current job	0.3	0.3	0.7	-0.1	-0.8	0.3	0.4	-0.8
Alcohol intake versus 10 years previously	2.3	3.5	7.8	-1.1	1.9	-2.8	1.4	1.7
Father’s age at death	1.5	2.0	3.2	0.7	1.8	-1.6	1.8	0.9
Worrier / anxious feelings	0.2	0.4	1.2	-0.8	-0.5	-0.1	-1.1	-0.4
Frequency of tiredness / lethargy in last 2 weeks	1.4	2.3	5.8	-0.3	-2.4	0.5	-1.3	-1.9
Falls in the last year	1.5	2.0	4.0	1.1	-1.8	2.0	-0.7	-1.1
Hair/balding pattern: Pattern 3	2.9	4.3	8.2	-0.7	-2.6	2.9	-1.4	-2.0
Number of live births	0.3	0.4	1.4	-0.6	-1.2	0.3	-0.5	0.2
Forced expiratory volume in 1-second (FEV1)	0.9	3.2	7.3	2.5	-0.5	-0.8	1.2	-2.7
Pulse rate	0.2	0.4	1.2	-0.7	-0.0	1.1	-0.5	-0.0
Happiness	1.1	1.3	3.4	1.1	-0.7	0.4	-1.0	-1.8
Noisy workplace	1.1	1.4	3.9	-0.6	-0.4	-2.0	-0.6	-1.5
Qualifications: A levels/AS levels or equivalent	1.1	2.5	3.7	1.9	1.9	1.4	1.8	-0.2
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.7	-0.0	-0.4	0.6	0.0	-0.8
Mouth/teeth dental problems: Dentures	0.7	1.2	3.8	-2.0	-1.2	0.0	0.4	0.7
Asthma	0.4	0.7	1.7	-0.5	-0.5	0.4	-1.3	-1.1
Medication: Ibuprofen (e.g. Nurofen)	1.8	2.3	3.8	0.8	-1.9	0.9	-1.9	-1.7
Medication: Cholesterol lowering	0.6	0.9	3.3	-0.9	0.2	-1.8	-0.1	0.5
Depression (self-reported)	0.4	0.5	1.0	0.7	0.8	-1.0	-0.3	-0.4
Medication: Lansoprazole	0.5	0.5	2.3	-0.4	0.3	-1.5	0.2	-0.1
Prospective memory result	0.4	0.5	1.8	0.2	0.6	-0.5	-0.4	-1.3
Lung cancer (father)	0.2	0.3	1.0	0.3	-0.0	-1.0	0.2	0.5
Illnesses of mother	1.4	1.8	3.5	0.7	1.9	-1.3	1.6	0.8
Forced expiratory volume in 1-second (FEV1), Best measure	0.7	2.3	6.8	1.9	-0.6	0.1	0.9	-2.6
Pulse wave Arterial Stiffness index	0.4	0.5	1.8	-0.5	0.1	0.3	0.7	1.3
Impedance of arm (left)	4.1	19.1	34.3	-2.7	5.9	-3.9	2.4	5.8
Arm fat mass (right)	1.1	4.7	8.3	1.8	-2.9	2.4	-1.8	-1.7
Trunk predicted mass	6.6	37.8	76.2	7.3	-5.7	5.1	-1.2	-8.7
Standing height	2.8	27.7	60.5	7.8	-2.1	3.3	1.7	-7.7
Length of working week for main job	2.2	2.4	4.8	-0.4	-2.1	2.2	-0.6	-1.4
Exposure to tobacco smoke at home	0.5	0.6	1.2	0.4	-1.0	0.6	-1.1	-0.0
Breastfed as a baby	1.0	1.2	3.8	-0.2	1.9	0.3	1.5	0.2
Tense / ‘highly strung’	0.5	0.8	1.9	0.9	1.0	-1.4	0.6	-0.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.1	0.3	0.5	-0.2	0.2	-1.1
Hair/balding pattern: Pattern 4	0.6	1.5	2.6	0.6	-1.4	1.0	-1.2	-1.6
Birth weight of first child	1.6	3.0	7.3	1.9	-1.8	0.8	0.1	-2.7
Peak expiratory flow (PEF)	0.7	1.6	4.7	0.4	-1.8	0.3	-0.2	-2.2
Pulse wave reflection index	0.5	0.6	1.5	-0.9	0.3	0.4	0.6	1.2
Ever highly irritable/argumentative for 2 days	1.6	1.9	3.8	-0.5	-1.6	-0.2	-2.0	-1.7
Loud music exposure frequency	0.4	0.4	1.4	0.2	0.8	0.4	-0.1	-1.2
Qualifications: O levels/GCSEs or equivalent	1.4	2.2	5.2	1.8	1.5	0.6	2.3	0.5
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	1.4	-0.8	0.8	-1.2	0.9	1.0
Blood clot in the leg (DVT)	1.2	1.5	4.9	-1.4	0.1	-0.7	0.5	2.2
Medication: Paracetamol	1.4	2.4	4.5	-0.8	-2.0	1.1	-2.1	-1.1
Headache pain in last month	0.7	1.1	2.9	-0.9	-1.1	0.7	-0.6	-1.7
Medication for cholesterol, blood pressure or diabetes	0.9	1.5	4.6	0.2	1.4	-0.2	2.1	0.9
Glaucoma (self-reported)	0.5	0.6	1.2	-1.1	1.0	-0.2	1.0	-0.2
Gout (self-reported)	0.3	0.5	1.5	0.2	0.5	-0.1	-1.2	0.8
Hypothyroidism/myxoedema (self-reported)	0.8	1.5	2.4	-1.2	-1.6	1.2	-1.0	-1.1
Medication: Amlodipine	1.9	2.7	5.8	0.3	-2.4	1.3	-1.2	-2.1
Medication: Ventolin 100micrograms inhaler	0.1	0.2	0.6	-0.3	-0.1	0.0	-0.8	-0.4
Birth weight	0.3	0.8	1.5	1.0	-0.2	0.2	1.1	-1.2
Chronic bronchitis/emphysema (mother)	1.2	1.4	3.3	-1.1	-0.2	-1.5	-1.8	0.2
High blood pressure (siblings)	3.2	4.6	8.5	1.3	-1.7	1.8	-2.5	-2.9
Forced vital capacity (FVC), Best measure	1.2	4.3	9.4	2.9	-0.2	0.6	1.8	-3.1
Body fat percentage	0.3	1.2	2.8	-0.8	-1.2	0.8	-1.7	0.9
Leg fat percentage (right)	0.7	2.4	5.4	-1.2	-2.3	1.0	-1.9	0.5
Arm fat-free mass (right)	6.7	34.3	69.7	6.2	-6.0	5.0	-1.6	-8.3
Exposure to tobacco smoke outside home	1.2	1.6	5.9	-0.9	-2.4	0.8	-0.7	0.2
Comparative body size at age 10	0.2	0.6	2.3	0.7	-0.0	1.5	-0.4	-0.1
Number of full brothers	0.8	1.0	3.3	1.1	-0.6	-0.4	-0.1	-1.8
Worry too long after embarrassment	0.3	0.5	2.0	0.5	0.5	-0.1	0.4	1.4
Seen a psychiatrist for nerves, anxiety, tension or depression	0.7	1.0	2.2	-0.4	-0.4	0.7	-1.5	-1.4
Wheeze or whistling in the chest in last year	0.4	0.8	3.4	0.6	0.5	-1.8	-0.0	-0.1
Number of children fathered	0.4	0.5	1.0	-0.7	0.4	-0.8	1.0	0.1
Reason for reducing amount of alcohol drunk: Health precaution	1.5	1.7	3.7	1.1	-0.9	1.9	-0.0	-1.7
Age at first live birth	1.1	2.0	5.8	0.5	2.4	-0.9	1.6	-0.7
Pulse wave peak to peak time	0.8	0.9	3.0	1.1	-0.3	0.1	-0.5	-1.7
Health satisfaction	0.3	0.4	0.9	-0.5	0.4	-0.6	-0.6	1.0
Shortness of breath walking on level ground	0.9	1.1	1.7	1.3	-0.9	0.4	-1.2	-1.1
Qualifications: College or University degree	0.8	2.5	7.2	2.7	0.4	1.4	0.1	-1.8
Eye problems/disorders: None of the above	0.2	0.3	1.2	-0.2	-0.1	-0.4	-1.1	-0.2
Mouth/teeth dental problems: Loose teeth	0.2	0.2	0.4	0.6	-0.4	-0.3	0.5	-0.2
Emphysema/chronic bronchitis	2.5	2.8	8.5	-1.9	0.5	-2.9	-1.2	-0.2
Medication for pain relief, constipation, heartburn	2.5	4.3	9.0	0.6	2.8	-0.7	3.0	2.0
Neck or shoulder pain in last month	1.0	1.4	3.2	1.8	-0.3	-1.5	-0.2	-1.2
Medication: Blood pressure	1.4	2.5	4.9	0.9	-2.2	1.7	-1.8	-0.6
Angina (self-reported)	0.3	0.4	0.8	0.4	-0.8	-0.5	0.3	-0.9
Migraine (self-reported)	0.6	0.8	2.3	-1.5	-0.1	0.9	-0.9	-0.2
Medication: Ibuprofen	1.5	1.8	2.9	0.5	-1.3	1.1	-1.7	-1.7
Medication: Allopurinol	0.3	0.4	1.0	0.8	0.2	-1.0	-0.2	0.6
Medication: Omeprazole	0.7	0.9	1.9	-1.1	-0.6	1.4	-0.6	-0.8
Medication: Seretide 50 evohaler	1.2	1.4	2.5	-0.1	-1.5	0.1	-1.6	-1.5
Mean time to correctly identify matches	0.2	0.4	0.8	-0.6	-0.8	0.9	-0.5	-0.4
Heart disease (mother)	2.1	2.5	6.4	-1.5	-1.8	0.6	-2.5	-0.5
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.7	0.8	1.9	0.6	-0.8	0.5	-1.4	1.0
Whole body fat mass	0.9	3.8	6.8	1.6	-2.6	2.1	-1.7	-1.5
Leg fat mass (right)	1.5	5.8	10.8	1.4	-3.3	2.6	-1.9	-2.4
Arm predicted mass (right)	6.7	34.2	68.2	5.8	-6.2	5.3	-1.8	-8.3
Pulse rate, automated reading	0.4	1.3	3.0	-1.2	-1.7	1.3	0.4	0.3
Alcohol intake frequency.	0.9	2.1	6.2	-1.5	-0.4	-2.5	-1.3	0.2
Comparative height size at age 10	2.4	13.0	27.7	5.3	-2.7	2.4	0.8	-4.8
Number of full sisters	0.5	0.6	1.9	1.4	0.1	-0.8	0.5	-0.3
Suffer from ‘nerves’	0.4	0.6	1.6	0.2	0.5	-0.8	-1.3	-0.7
Overall health rating	1.4	3.1	6.6	0.6	-2.6	0.6	-2.4	-1.5
Chest pain or discomfort	0.6	0.9	2.3	1.5	-1.0	0.7	-0.7	-0.8
Had major operations	0.3	0.4	1.2	-0.8	-0.3	0.0	-0.3	1.1
Age at last live birth	0.9	1.3	4.5	0.6	0.8	-0.8	0.5	-2.1
Family relationship satisfaction	1.4	1.7	5.2	-1.0	0.2	1.5	-0.3	-2.3
Leg pain on walking	0.9	1.2	2.3	-0.7	1.2	-0.4	1.5	1.2
Qualifications: NVQ or HND or HNC or equivalent	0.8	0.9	3.1	-0.2	-0.4	-1.1	0.0	1.8
Commuting to job workplace: Car/motor vehicle	1.2	1.4	2.5	-1.6	-0.8	1.5	-0.8	-0.8
Illness, injury, bereavement, stress in last 2 years	0.6	0.8	2.3	1.2	0.1	1.5	-0.1	-0.2
Medication: Aspirin	0.2	0.3	0.9	0.8	-0.9	0.2	-0.2	0.0
Supplements: Vitamin C	0.3	0.4	0.8	0.3	-0.7	0.9	-0.5	-0.3
Knee pain experienced in last month	0.9	1.4	2.4	-1.5	-0.7	1.3	-0.7	1.5
Hypertension (Self-reported)	1.7	4.8	8.0	-0.2	-2.5	2.3	-2.8	-2.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	2.2	-1.5	0.1	-0.3	-0.2	0.9
Illnesses of father: Heart disease	0.5	0.7	2.0	-0.7	-0.3	0.3	-0.9	-1.4
Illnesses of siblings: Diabetes	0.5	0.6	1.7	-0.3	-0.8	-1.3	-0.7	-0.3
Smoking status: Previous	1.1	1.6	3.5	0.1	-0.6	-1.9	-1.6	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	2.4	4.9	14.6	2.4	-1.5	0.9	-1.1	-3.8
Whole body fat-free mass	6.5	37.4	75.5	6.9	-5.8	5.2	-1.7	-8.7
Leg fat-free mass (right)	5.5	29.6	59.4	5.8	-5.2	4.8	-2.1	-7.7
Arm fat percentage (left)	0.4	1.6	3.1	-0.4	-1.6	1.2	-1.8	0.9
Average weekly red wine intake	0.7	1.1	3.1	1.8	-0.1	0.6	0.6	-1.2
Handedness (chirality/laterality): Left-handed	1.4	1.7	5.9	-0.5	1.5	-2.4	0.4	-0.3
Mood swings	0.4	0.8	3.3	0.2	-0.2	-0.8	-1.8	0.3
Loneliness, isolation	2.7	3.7	6.2	-2.5	-1.0	-2.2	-2.0	-1.5
Long-standing illness, disability or infirmity	0.5	0.7	1.7	0.4	-0.5	1.3	0.1	-1.2
Ever had bowel cancer screening	0.8	0.9	1.6	-1.3	-0.9	0.2	-1.0	-1.0
Diabetes diagnosed by doctor	0.3	0.5	0.6	0.8	-0.8	0.5	0.7	0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.2	0.3	0.4	0.0	0.7	0.6	0.7	0.3
Friendships satisfaction	0.6	0.7	1.7	-1.3	0.8	0.7	-0.6	0.5
Qualifications: nursing, teaching	0.8	1.3	4.7	-0.4	-0.6	2.2	-0.9	-0.7
Commuting to job workplace: Walk	0.4	0.4	1.1	0.4	-0.2	-1.1	0.4	0.7
Eye problems/disorders: Cataract	1.1	1.2	3.4	1.1	-1.8	1.0	-0.3	0.7
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.6	-0.2	-0.6	1.3	0.2	0.6
Medication for cholesterol	0.2	0.2	0.5	-0.7	0.2	0.3	-0.4	-0.7
Medication: Laxatives (e.g. Dulcolax, Senokot)	0.6	0.7	2.7	0.2	-1.6	0.0	-0.4	-0.8
Back pain experienced in last month	0.6	0.8	1.5	0.9	0.9	-1.2	0.6	-0.8
Mineral and other dietary supplements	2.3	3.2	6.3	0.1	-2.5	0.0	-2.3	-2.1
Breast cancer (self-reported)	0.9	1.1	2.5	-1.2	-0.6	1.6	-0.3	-1.0
Asthma (self-reported)	0.5	1.0	2.2	-0.4	-0.6	0.8	-1.5	-1.2
Osteoporosis (self-reported)	0.2	0.3	1.4	-0.3	1.2	0.0	-0.2	0.1
Osteoarthritis (self-reported)	2.8	3.6	8.1	-0.9	2.8	-0.1	1.6	2.5
Medication: Aspirin	0.3	0.4	1.1	1.1	-0.4	0.3	0.5	0.6
Medication: Gliclazide	0.2	0.3	0.5	-0.3	-0.7	0.6	0.3	-0.5
Illnesses of father: None of the above (group 1)	0.5	0.6	1.2	0.4	1.1	0.7	0.9	0.6
Smoking status: Current	0.3	0.5	2.0	0.5	-1.4	-0.4	-0.5	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.3	0.6	1.4	-0.9	0.5	-1.2	0.6	0.3
Whole body water mass	6.5	36.9	73.6	6.9	-5.8	5.2	-1.7	-8.6
Leg predicted mass (right)	5.5	29.4	59.0	5.9	-5.1	4.8	-2.0	-7.7
Arm fat mass (left)	1.3	5.3	10.2	2.0	-3.2	2.4	-1.9	-1.7
Number of self-reported non-cancer illnesses	0.2	0.4	1.7	-0.4	1.3	0.3	-0.1	0.2
Average weekly champagne plus white wine intake	1.1	1.5	2.9	1.4	0.8	1.0	1.7	-1.0
Miserableness	0.4	0.7	2.1	0.1	0.5	-0.8	-0.5	-1.4
Guilty feelings	1.0	1.5	5.0	2.2	0.3	-1.2	0.1	-1.2
Wears glasses or contact lenses	0.2	0.2	0.5	0.1	-0.2	-0.6	0.7	-0.2
Ever taken oral contraceptive pill	0.7	0.7	1.6	-1.2	-0.1	-1.3	-0.6	-0.5
Hearing aid user	1.4	1.6	2.6	-1.4	1.6	0.2	0.8	1.6
Mother’s age at death	1.4	1.7	5.1	1.5	0.7	-0.1	2.3	-0.9
Financial situation satisfaction	0.4	0.5	1.2	-1.1	0.5	-0.5	-0.7	-0.5
Tinnitus: Yes, now most or all of the time	0.3	0.3	0.9	-0.5	-0.3	0.5	0.4	-0.9
Commuting to job workplace: Public transport	0.5	0.6	1.1	-0.6	0.6	-0.4	1.1	1.0
Eye problems/disorders: Glaucoma	0.8	1.0	1.8	-1.2	1.3	-0.6	1.1	0.3
Medication: Blood pressure	0.6	1.1	2.9	0.4	-1.7	1.0	-0.8	-0.9
Pain type(s) experienced in last month: Hip pain	0.1	0.2	0.6	-0.2	0.8	-0.2	-0.0	-0.5
Supplements: Fish oil (including cod liver oil)	1.4	1.8	3.7	-0.3	1.5	-0.4	1.7	1.9
High cholesterol (Self-reported)	0.8	1.5	3.1	-1.3	-0.5	-1.5	-0.3	1.8
Medication: Bendroflumethiazide	1.8	2.7	5.3	-0.3	-2.3	1.5	-2.3	-0.8
Medication: Paracetamol	1.6	2.5	4.2	-1.2	-2.0	1.2	-1.8	-1.4
Medication: Lisinopril	0.7	0.9	2.1	0.7	-0.6	-0.5	-1.4	-1.1
Medication: Atorvastatin	3.6	4.5	10.5	0.0	1.7	-0.2	3.2	3.0
Illnesses of father: High blood pressure	0.6	0.8	2.1	1.3	1.4	0.1	-0.3	-0.3
Alcohol drinker status: Never	1.4	1.7	4.3	0.1	-2.1	1.5	-1.3	-0.6
Ever smoked	0.7	1.3	3.0	1.7	-1.4	-0.6	-0.8	-0.8
Basal metabolic rate	5.9	32.6	61.6	6.4	-5.7	5.0	-1.9	-7.8
Leg fat percentage (left)	0.6	2.3	5.2	-1.3	-2.3	1.0	-1.9	0.2
Arm fat-free mass (left)	6.5	32.8	61.2	6.2	-5.8	5.2	-1.7	-7.8
Number of operations (self-reported)	1.7	2.5	6.1	-1.0	-2.5	0.9	-1.9	-1.0
Average weekly beer plus cider intake	0.2	0.2	0.6	0.8	-0.6	0.1	-0.3	0.2
Irritability	0.2	0.3	0.6	-0.8	-0.4	-0.4	-0.5	-0.8
Risk taking	0.7	1.1	3.2	-0.6	-1.8	0.1	-0.8	-1.0
Ever had prostate specific antigen (PSA) test	1.4	1.6	2.8	-1.5	-0.5	1.6	-1.7	0.5
Fractured/broken bones in last 5 years	1.8	2.3	3.9	0.3	-1.8	1.9	-2.0	-0.9
Age started oral contraceptive pill	1.6	1.9	5.3	-0.8	2.3	-0.9	1.4	0.9
Diastolic blood pressure, automated reading	0.7	2.3	5.6	-0.9	-1.5	2.4	-1.2	-1.1
Ever depressed for a whole week	0.8	1.0	3.9	0.9	-0.4	0.3	-0.4	-2.0
Unable to work because of sickness or disability	1.2	1.5	4.1	-0.1	-1.7	-0.6	-2.0	-0.5
Commuting to job workplace: Cycle	1.9	2.3	6.5	-1.8	-0.0	-0.0	-1.3	-2.5
Myopia	0.3	0.4	1.3	1.1	0.3	0.2	0.3	-0.8
Vascular/heart problems diagnosed by doctor	1.3	3.6	8.0	0.4	2.0	-1.3	2.8	2.0
Cholesterol lowering medication	0.8	1.1	2.8	1.2	0.6	-0.6	1.7	0.9
Medication: Omeprazole (e.g. Zanprol)	1.7	2.1	7.4	-0.5	-0.9	2.7	-1.0	-1.0
Pain experienced in last month	0.2	0.3	0.8	-0.3	0.0	0.9	0.7	0.4
Supplements: Calcium	1.5	1.7	4.4	1.6	1.2	-0.1	2.1	0.1
Basal cell carcinoma (self-reported)	0.3	0.4	1.3	-0.0	0.2	0.1	-0.7	-1.1
Heart attack/myocardial infarction (self-reported)	3.2	4.1	11.4	0.7	2.3	-3.4	1.7	0.8
Deep venous thrombosis (DVT) (self-reported)	1.3	1.7	5.5	-1.5	0.2	-0.6	0.6	2.4
Heart disease (siblings)	1.2	1.4	3.6	0.8	-1.5	0.4	-1.9	-0.6
Alcohol drinker status: Previous	1.6	1.8	5.4	-1.0	-0.3	-2.3	-1.5	-0.5
Pack years of smoking	0.9	1.3	5.0	-0.5	-0.6	1.0	0.3	2.2
Impedance of whole body	3.9	19.8	32.7	-3.2	5.7	-4.1	2.7	5.7
Leg fat mass (left)	1.4	5.3	9.5	1.4	-3.1	2.4	-1.9	-2.4
Arm predicted mass (left)	6.3	32.2	58.5	6.3	-5.8	5.2	-1.5	-7.7