Best TWAS P=4.16e-12 · Best GWAS P=4.78e-12 conditioned to 0.144
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Artery Tibial | SENP6 | 0.08 | 0.00 | enet | 5 | 0.00 | 8.2e-01 | 6.5 | 5.7 | 1.4e-08 | 0.76 | 0.03 | 0.61 | FALSE |
| 2 | GTEx | Heart Left Ventricle | MYO6 | 0.09 | 0.00 | lasso | 7 | 0.00 | 5.6e-01 | -5.5 | 5.1 | 3.0e-07 | 0.13 | 0.15 | 0.04 | FALSE |
| 3 | METSIM | Adipose | COL12A1 | 0.04 | 0.01 | blup | 309 | 0.02 | 5.1e-04 | -2.2 | -6.1 | 1.2e-09 | -0.48 | 0.12 | 0.51 | TRUE |
| 4 | ROSMAP | Brain Pre-frontal Cortex | SENP6 | 0.17 | 0.14 | blup | 355 | 0.17 | 2.5e-21 | -5.0 | -6.9 | 4.2e-12 | -0.41 | 0.97 | 0.03 | TRUE |