[Hub]/) : Traits : Sitting height :

chr6:79,646,575-84,576,263

Best TWAS P=1.01e-67 · Best GWAS P=2.9e-86 conditioned to NaN

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex BCKDHB 0.11 0.09 bslmm 563 0.09 1.1e-10 11.33 9.4 3.6e-21 -0.32 1.00 0.00 FALSE
2 CommonMind Brain Pre-frontal Cortex TTK 0.07 0.00 bslmm 472 0.02 3.8e-03 -0.53 -5.7 1.2e-08 0.21 0.13 0.05 FALSE
3 GTEx Adipose Subcutaneous RP11-250B2.6 0.07 0.04 lasso 4 0.05 4.4e-05 10.42 -6.6 4.6e-11 0.26 0.64 0.06 FALSE
4 GTEx Adipose Visceral Omentum RP11-250B2.3 0.13 0.00 enet 13 0.01 8.2e-02 -8.43 -6.4 1.7e-10 0.23 0.06 0.12 FALSE
5 GTEx Adipose Visceral Omentum RP11-250B2.6 0.16 0.05 lasso 6 0.06 7.8e-04 16.34 -17.0 4.0e-65 0.55 0.01 0.97 FALSE
6 GTEx Artery Aorta BCKDHB 0.14 0.14 lasso 1 0.13 9.8e-08 11.36 11.4 6.4e-30 -0.28 0.99 0.00 FALSE
7 GTEx Artery Aorta ELOVL4 0.11 0.13 lasso 2 0.11 1.7e-06 9.76 9.7 5.0e-22 -0.39 0.93 0.02 TRUE
8 GTEx Artery Coronary BCKDHB 0.29 0.05 lasso 27 0.11 1.7e-04 11.33 11.8 5.6e-32 -0.23 0.40 0.06 TRUE
9 GTEx Artery Tibial BCKDHB 0.16 0.16 lasso 11 0.15 4.9e-12 11.31 10.8 2.2e-27 -0.28 1.00 0.00 FALSE
10 GTEx Artery Tibial ELOVL4 0.13 0.12 lasso 8 0.10 2.0e-08 8.88 8.6 6.1e-18 -0.40 1.00 0.00 FALSE
11 GTEx Brain Caudate basal ganglia BCKDHB 0.21 -0.01 enet 53 0.00 4.5e-01 -17.21 8.6 1.1e-17 -0.42 0.05 0.48 FALSE
12 GTEx Brain Cerebellar Hemisphere RP11-250B2.3 0.30 0.05 enet 32 0.12 5.2e-04 -17.21 -7.4 1.8e-13 0.47 0.01 0.90 FALSE
13 GTEx Brain Cerebellum RP11-250B2.5 0.43 0.11 lasso 5 0.14 4.7e-05 -17.67 -14.5 1.5e-47 0.53 0.00 0.99 FALSE
14 GTEx Breast Mammary Tissue RP11-250B2.3 0.13 0.06 lasso 4 0.04 2.6e-03 -8.43 -9.4 4.4e-21 0.34 0.03 0.83 FALSE
15 GTEx Breast Mammary Tissue RP11-250B2.5 0.13 0.11 enet 16 0.08 5.1e-05 -6.21 -5.7 1.6e-08 0.27 0.04 0.94 FALSE
16 GTEx Breast Mammary Tissue RP11-250B2.6 0.12 0.02 enet 9 0.03 1.7e-02 10.44 -6.1 8.2e-10 0.22 0.25 0.22 FALSE
17 GTEx Breast Mammary Tissue (Male) RP11-250B2.5 0.12 0.09 lasso 4 0.08 7.5e-03 -6.21 -5.3 1.4e-07 0.19 0.06 0.29 FALSE
18 GTEx Breast Mammary Tissue (Female) RP11-250B2.3 0.16 0.06 enet 11 0.04 2.4e-02 15.81 -12.0 2.3e-33 0.49 0.03 0.76 FALSE
19 GTEx Breast Mammary Tissue (Female) RP11-250B2.5 0.08 -0.01 lasso 4 -0.01 7.0e-01 -16.38 -9.2 5.0e-20 0.31 0.03 0.53 FALSE
20 GTEx Cells EBV-transformed lymphocytes BCKDHB 0.15 0.11 enet 34 0.07 3.1e-03 10.43 5.3 1.1e-07 -0.33 0.30 0.27 FALSE
21 GTEx Cells EBV-transformed lymphocytes RP11-250B2.6 0.21 0.03 enet 37 0.13 4.7e-05 11.33 -8.6 1.0e-17 0.14 0.11 0.28 FALSE
22 GTEx Cells Transformed fibroblasts BCKDHB 0.16 0.02 enet 42 0.04 3.7e-04 10.34 16.1 1.3e-58 -0.55 0.49 0.29 TRUE
23 GTEx Cells Transformed fibroblasts ELOVL4 0.09 0.05 lasso 7 0.06 2.8e-05 7.63 6.6 3.4e-11 -0.25 0.32 0.04 FALSE
24 GTEx Cells Transformed fibroblasts RP11-250B2.6 0.11 0.01 lasso 7 0.00 1.4e-01 -17.04 -13.2 6.2e-40 0.57 0.02 0.95 FALSE
25 GTEx Colon Transverse RP11-250B2.5 0.13 0.02 enet 3 0.01 6.3e-02 -8.43 -14.1 5.3e-45 0.50 0.02 0.82 TRUE
26 GTEx Colon Transverse RP11-250B2.6 0.15 0.16 lasso 2 0.13 9.8e-07 10.34 -9.7 2.3e-22 0.27 0.94 0.02 FALSE
27 GTEx Esophagus Mucosa BCKDHB 0.17 0.16 lasso 6 0.15 3.9e-10 9.25 -7.9 2.4e-15 0.37 1.00 0.00 FALSE
28 GTEx Esophagus Mucosa RP11-250B2.6 0.20 0.16 lasso 7 0.23 3.3e-15 -17.04 -17.4 1.7e-67 0.65 0.02 0.98 TRUE
29 GTEx Esophagus Muscularis BCKDHB 0.18 0.07 enet 25 0.06 2.4e-04 11.33 10.3 5.7e-25 -0.28 0.93 0.02 TRUE
30 GTEx Esophagus Muscularis ELOVL4 0.16 0.05 enet 18 0.11 3.4e-07 9.88 7.6 3.9e-14 -0.30 0.91 0.01 FALSE
31 GTEx Esophagus Muscularis RP11-250B2.5 0.16 0.00 lasso 6 0.00 4.4e-01 9.72 -7.4 1.2e-13 0.38 0.07 0.21 FALSE
32 GTEx Heart Atrial Appendage RP11-250B2.6 0.20 0.00 enet 17 0.03 2.6e-02 -6.25 -17.0 3.5e-65 0.32 0.07 0.30 TRUE
33 GTEx Heart Left Ventricle RP11-250B2.6 0.09 0.00 enet 6 0.02 2.0e-02 16.11 -16.0 1.2e-57 0.59 0.06 0.64 FALSE
34 GTEx Lung BCKDHB 0.09 0.06 enet 10 0.05 1.8e-04 11.34 11.3 8.0e-30 -0.28 0.81 0.12 FALSE
35 GTEx Lung RP11-250B2.6 0.09 0.05 enet 16 0.07 5.3e-06 10.44 -15.6 1.6e-54 0.38 0.57 0.34 FALSE
36 GTEx Muscle Skeletal RP11-250B2.6 0.07 0.04 lasso 5 0.04 4.2e-05 16.93 -17.4 1.0e-67 0.67 0.63 0.34 FALSE
37 GTEx Nerve Tibial BCKDHB 0.18 0.11 lasso 9 0.10 2.4e-07 11.33 11.3 1.6e-29 -0.28 1.00 0.00 FALSE
38 GTEx Nerve Tibial SH3BGRL2 0.18 0.02 lasso 5 0.04 1.4e-03 9.84 6.2 7.4e-10 -0.29 0.27 0.12 FALSE
39 GTEx Nerve Tibial RP11-250B2.5 0.22 0.08 lasso 6 0.08 2.6e-06 1.06 -7.5 8.4e-14 0.39 0.12 0.88 FALSE
40 GTEx Nerve Tibial RP11-250B2.6 0.13 0.09 enet 10 0.09 8.7e-07 3.62 -6.0 1.7e-09 0.31 0.99 0.00 FALSE
41 GTEx Pancreas BCKDHB 0.14 0.08 enet 6 0.05 3.8e-03 4.08 7.2 4.2e-13 -0.26 0.40 0.16 FALSE
42 GTEx Skin Not Sun Exposed Suprapubic RP11-250B2.3 0.12 0.11 lasso 4 0.15 1.1e-08 15.81 -8.2 2.3e-16 0.31 0.37 0.57 FALSE
43 GTEx Skin Not Sun Exposed Suprapubic RP11-250B2.5 0.13 0.16 lasso 4 0.17 1.1e-09 15.81 -12.0 2.5e-33 0.48 0.28 0.71 FALSE
44 GTEx Skin Not Sun Exposed Suprapubic RP11-250B2.6 0.08 0.05 lasso 4 0.01 8.1e-02 10.43 -10.2 2.0e-24 0.25 0.20 0.16 FALSE
45 GTEx Skin Sun Exposed Lower leg RP11-250B2.3 0.12 0.06 enet 29 0.07 2.5e-06 15.81 -11.5 8.7e-31 0.54 0.14 0.86 FALSE
46 GTEx Skin Sun Exposed Lower leg RP11-250B2.5 0.09 0.03 enet 34 0.06 4.6e-06 17.57 -10.5 6.1e-26 0.49 0.01 0.99 FALSE
47 GTEx Stomach RP11-250B2.3 0.12 -0.01 lasso 8 0.00 1.9e-01 1.06 -5.8 5.5e-09 0.27 0.09 0.15 FALSE
48 GTEx Stomach RP11-250B2.6 0.13 0.15 lasso 6 0.12 2.5e-06 10.34 -9.5 1.4e-21 0.25 0.79 0.16 FALSE
49 GTEx Testis ELOVL4 0.31 0.19 lasso 7 0.18 1.9e-08 -6.05 -5.2 1.7e-07 0.13 0.96 0.00 TRUE
50 GTEx Testis RP11-250B2.5 0.13 0.17 lasso 3 0.14 7.0e-07 -16.99 -16.7 9.1e-63 0.72 0.03 0.97 FALSE
51 GTEx Testis RP11-250B2.6 0.09 0.05 lasso 6 0.04 6.9e-03 10.43 -9.7 2.9e-22 0.29 0.40 0.06 FALSE
52 GTEx Thyroid BCKDHB 0.17 0.06 lasso 8 0.10 3.4e-08 10.43 14.3 1.2e-46 -0.50 0.76 0.24 TRUE
53 GTEx Thyroid RP11-250B2.6 0.11 0.10 lasso 2 0.07 3.2e-06 10.34 -10.3 4.4e-25 0.27 1.00 0.00 FALSE
54 METSIM Adipose BCKDHB 0.05 0.03 blup 558 0.05 1.1e-07 -16.99 12.1 6.3e-34 -0.54 1.00 0.00 FALSE
55 METSIM Adipose DOPEY1 0.08 0.08 lasso 10 0.07 2.4e-10 4.63 -5.2 1.6e-07 0.01 0.27 0.73 FALSE
56 METSIM Adipose ELOVL4 0.06 0.03 bslmm 500 0.04 3.2e-06 8.93 9.6 8.0e-22 -0.42 1.00 0.00 FALSE
57 METSIM Adipose RP11-250B2.6 0.04 0.04 lasso 12 0.02 1.7e-04 17.57 -16.1 1.5e-58 0.61 0.73 0.02 TRUE
58 ROSMAP Brain Pre-frontal Cortex BCKDHB 0.18 0.13 lasso 6 0.14 2.9e-17 11.33 10.0 1.8e-23 -0.31 1.00 0.00 FALSE
59 ROSMAP Brain Pre-frontal Cortex FAM46A 0.08 0.01 blup 495 0.03 2.7e-04 3.97 5.1 2.8e-07 -0.01 0.65 0.01 TRUE
60 ROSMAP Brain Pre-frontal Cortex RP11-250B2.3 0.08 0.02 blup 402 0.04 5.8e-06 4.41 -9.2 2.7e-20 0.22 0.79 0.02 FALSE
61 YFS Blood BCKDHB 0.01 0.01 blup 557 0.00 1.3e-02 10.74 8.7 5.3e-18 -0.44 0.28 0.13 FALSE
62 YFS Blood DOPEY1 0.18 0.21 lasso 9 0.21 1.4e-67 4.63 -5.2 2.1e-07 0.03 0.82 0.18 FALSE
63 The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma BCKDHB 0.12 0.06 lasso 4 0.06 4.2e-07 14.72 -12.7 6.7e-37 0.45 0.98 0.00 FALSE
64 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma DOPEY1 0.08 0.08 blup 47 0.09 2.3e-10 4.63 -5.5 4.3e-08 0.04 0.03 0.97 FALSE
65 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma ELOVL4 0.09 0.04 enet 4 0.02 1.9e-03 9.93 9.9 2.7e-23 -0.47 0.00 1.00 FALSE
66 The Cancer Genome Atlas Liver Hepatocellular Carcinoma DOPEY1 0.06 0.08 lasso 2 0.04 3.9e-03 6.19 -6.2 6.4e-10 0.01 0.00 0.94 TRUE
67 The Cancer Genome Atlas Testicular Germ Cell Tumors BCKDHB 0.19 0.02 blup 137 0.06 2.6e-03 11.30 7.2 4.1e-13 -0.13 0.03 0.05 FALSE