Hub : Genes

COL12A1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0590	0.0200	3.5e-05	0.022	0.043	0.020	0.040	0.018	0.00097	5.7e-06	0.0015	1.2e-05	0.0028
2	GTEx	Testis	0.4570	0.1010	9.7e-05	-0.004	NA	-0.005	NA	0.003	0.54000	NA	0.6700	NA	0.2300
3	METSIM	Adipose	0.0366	0.0159	1.6e-03	0.006	0.020	0.010	0.017	0.003	0.03900	5.1e-04	0.0110	1.3e-03	0.0960
4	ROSMAP	Brain Pre-frontal Cortex	0.0644	0.0284	3.4e-03	0.023	0.008	0.003	0.012	0.006	0.00048	2.5e-02	0.1000	8.5e-03	0.0460
5	TCGA	Kidney Renal Clear Cell Carcinoma	0.0792	0.0352	7.7e-03	0.000	0.004	0.002	NA	0.001	0.29000	1.0e-01	0.1700	NA	0.2400
6	TCGA	Uterine Corpus Endometrial Carcinoma	0.2220	0.0940	4.4e-03	0.038	-0.011	-0.010	NA	0.033	0.03200	9.5e-01	0.7800	NA	0.0420

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6
Bipolar Disorder (2018)	0.7	1.0	2.4	-0.9	-0.8	-0.8	-0.6	-1.6	-1.1
Bipolar Disorder or Schizophrenia	0.3	0.7	1.8	-0.3	0.3	1.0	0.0	-1.1	-1.4
Depressed Affect (Nagel 2018)	0.6	1.3	2.8	-1.7	0.5	1.6	-0.3	-0.9	-1.1
Depression (Nagel 2018)	0.7	1.1	2.4	-1.6	0.8	-0.2	-1.5	-0.9	0.4
Intelligence (Savage-Jansen 2018)	0.5	1.7	4.0	1.5	-0.8	-2.0	-1.7	0.2	-0.3
Neuroticism (Nagel 2018)	0.4	1.0	3.6	-1.4	0.5	1.9	-0.5	-0.2	0.1
Schizophrenia (2018)	0.4	0.9	3.6	0.4	1.1	1.9	0.5	-0.2	0.0
Schizophrenia vs Biploar Disorder	0.2	0.2	0.5	0.4	0.6	0.7	-0.2	0.4	-0.1
Worry (Nagel 2018)	1.0	2.1	8.2	0.3	0.3	2.9	0.5	1.2	1.5
Alzheimer’s Disease (in mother)	0.3	0.3	0.9	-0.6	-0.2	0.0	-0.3	0.9	0.6
Alzheimer’s Disease (in father)	0.7	0.8	4.0	-0.2	0.3	0.4	0.7	-0.3	-2.0
Alzheimer’s Disease (including proxy)	0.3	0.4	1.4	-0.6	-0.2	-0.1	0.3	1.2	-0.6
Crohns Disease (2017)	0.2	0.5	1.7	-0.8	-0.8	0.4	-0.3	-1.3	-0.1
Irritable Bowel Disease (IBD)	0.2	0.5	1.6	0.6	-0.1	0.4	0.3	-1.3	-0.9
Ulcerative Colitis (UC)	0.3	0.6	1.7	1.3	1.1	0.4	0.4	-0.2	-0.6
Major Depression (MDD)	0.4	0.5	1.7	-0.1	0.7	0.3	-0.0	-0.8	1.3
Reaction Time	0.5	0.9	1.6	-1.0	1.3	0.3	-0.9	-1.1	-0.8
Verbal and Numeric Reasoning (VNR)	0.8	1.8	6.1	0.9	-1.2	-1.3	-2.5	0.8	0.6
Breast Cancer	0.6	1.4	5.7	-1.0	0.2	-0.0	-2.4	1.3	-0.3
Ovarian Cancer	1.1	1.4	3.6	-0.8	-1.9	-1.0	-0.9	-0.5	-1.4
Prostate Cancer	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Age at First Birth	1.2	1.8	5.1	-1.8	-0.8	-2.2	0.2	-0.8	-0.9
Bipolar Disorder (2011)	1.3	1.2	3.8	-1.6	0.0	-2.0	-1.0	0.0	0.0
Body Mass Index (BMI) (2010)	1.0	1.4	3.6	1.0	1.0	1.9	1.2	-1.2	0.0
Coronary Artery Disease (CAD)	0.6	0.7	1.9	0.2	1.4	-0.6	-0.5	0.6	-1.1
Crohns Disease (2012)	0.5	0.9	2.5	-1.4	-0.8	0.1	0.0	-1.6	-0.3
Mean Putamen Volume	1.4	1.6	2.8	1.6	1.3	1.7	1.3	0.9	-0.5
Fasting Glucose	1.3	1.6	3.0	1.7	1.2	1.4	1.1	-1.2	0.6
HbA1C	1.1	1.2	3.6	0.4	-1.9	-1.0	0.2	-1.6	0.3
HDL Cholesterol	0.5	0.8	2.8	0.2	0.7	1.0	-0.3	0.8	-1.7
LDL Cholesterol	0.7	1.1	5.3	0.0	0.8	2.3	-0.4	-0.2	0.5
Lupus	0.9	1.3	4.3	0.1	1.8	0.4	-0.1	-2.1	0.0
Neuroticism (2016)	0.5	0.7	2.3	-0.7	-0.6	-1.0	1.5	-0.3	0.0
Primary Biliary Cirrhosis	0.2	0.3	0.7	0.7	-0.2	0.8	0.8	0.1	0.0
Rheumatoid Arthritis	1.5	2.1	5.5	-0.7	0.9	0.4	1.2	-2.0	-2.3
Schizophrenia (2014)	0.3	0.6	2.5	-0.1	0.7	1.6	-0.0	0.3	-0.7
Triglycerides	0.4	0.6	1.4	1.2	0.3	0.3	1.1	-0.7	0.5
Type 2 Diabetes (T2D) (2012)	0.6	0.6	1.1	0.8	1.1	0.8	0.7	-0.9	0.4
Ulcerative Colitis	0.4	0.6	2.4	1.6	0.3	0.6	0.8	0.0	-0.2
Blood Eosinophil Count	0.5	3.5	9.1	-2.5	1.1	-1.6	-3.0	-0.9	0.9
Blood Platelet Count	0.3	3.3	8.8	-0.4	0.8	-0.3	-2.8	1.4	3.0
Blood Red Count	0.2	1.6	3.2	-1.4	1.8	-1.6	-0.0	-0.9	0.8
Blood White Count	0.4	2.8	9.2	-0.8	-0.2	-1.7	-1.1	-1.5	3.0
Heel T-Score	0.0	0.1	0.5	-0.3	-0.7	-0.2	-0.0	-0.2	0.4
BMI	0.4	2.4	6.2	-2.1	1.2	-0.2	1.0	-2.5	-1.1
Height	0.9	16.4	89.3	0.1	-2.5	-9.4	-0.6	1.0	1.3
Waist Hip Ratio (WHR)	0.6	2.8	7.8	-1.4	-1.5	-2.8	-1.6	-1.4	0.5
Systolic Blood Pressure	0.3	1.5	3.2	-1.8	-1.8	-1.2	0.7	-0.3	-0.5
Smoking Status	0.1	0.2	0.3	-0.4	-0.5	-0.2	-0.5	-0.5	-0.6
Allergy or Eczema	0.2	0.5	1.5	0.1	0.9	0.7	0.4	1.2	0.4
Cardiovascular Disease	0.4	1.5	3.6	-0.1	-1.6	-1.9	1.5	0.0	0.6
Hypothyroidism (self reported)	0.2	0.5	1.2	0.3	-1.1	-0.2	0.2	-0.7	-0.9
Respiratory disease	0.4	0.9	1.7	-0.9	1.3	0.1	-0.9	-0.9	1.2
Type 2 Diabetes (T2D) (2018)	2.0	3.8	7.6	-2.7	0.1	-2.8	-1.9	-1.8	-1.2
Lung FEV1/FVC ratio	0.1	0.8	3.1	-1.8	-0.4	0.1	-0.1	1.1	0.3
Lung FVC	0.1	0.5	1.6	1.1	0.1	0.6	-1.3	0.2	0.3
Neuroticism	0.5	1.1	4.6	-0.4	1.4	2.1	0.3	0.1	0.2
Chronotype (morning person)	0.6	1.3	2.9	-1.2	-1.7	0.6	-0.2	1.0	1.5
Hair Pigment	0.1	1.8	6.6	0.7	0.3	-1.3	2.6	1.3	-0.5
Tanning	0.2	2.6	4.8	-2.1	-2.2	-0.8	-1.5	-1.8	0.2
Hand grip strength (left)	0.4	1.1	6.1	2.5	-0.5	-0.2	-0.2	0.0	-0.6
Number of treatments/medications taken	0.3	0.5	1.6	0.2	1.2	-0.2	1.1	-0.3	-0.5
Average weekly spirits intake	1.0	1.2	2.7	0.6	1.5	-1.6	0.5	0.2	-1.2
Sensitivity / hurt feelings	0.3	0.5	1.9	-1.4	0.4	0.6	-0.5	-0.7	0.2
Frequency of depressed mood in last 2 weeks	0.6	0.9	2.5	-0.8	1.3	0.4	-0.4	-1.6	0.4
Hearing difficulty/problems: Yes	0.5	0.8	2.1	-0.9	0.6	1.1	0.3	-1.5	-0.2
Relative age of first facial hair	1.0	2.1	5.4	2.3	0.5	1.4	0.1	2.0	1.0
Other serious medical condition/disability diagnosed by doctor	0.9	1.2	3.7	-0.1	0.1	0.7	-1.2	-1.9	1.2
Ever used hormone-replacement therapy (HRT)	0.9	1.2	2.7	-0.1	1.2	0.8	1.4	-0.3	-1.6
Ever had hysterectomy (womb removed)	0.7	0.7	1.6	-0.7	1.3	-0.6	0.6	0.7	-1.1
Systolic blood pressure, automated reading	0.3	0.8	3.8	-1.9	0.6	0.7	-0.3	-0.6	0.1
Eye problems/disorders: Diabetes related eye disease	0.7	0.7	2.9	-0.6	0.6	-0.7	0.2	-1.7	0.3
Angina	0.4	0.5	1.3	-0.3	0.7	0.2	0.5	1.2	0.9
Medication for hormone replacement therapy	1.8	2.0	4.0	0.5	1.2	1.6	1.8	-0.2	-2.0
Vitamin and mineral supplements	0.1	0.2	0.3	-0.6	-0.3	0.0	-0.5	-0.1	-0.6
Supplements: Zinc	0.5	0.5	1.6	0.3	-1.3	-0.5	0.8	0.5	0.6
Medication: Co-codamol	0.7	0.8	3.3	1.0	1.8	-0.1	0.5	0.4	-0.2
Medication: Metformin	1.7	2.3	5.3	-2.3	1.5	-1.3	-1.4	-1.6	-0.7
Diabetes (father)	0.2	0.3	0.8	0.3	0.8	0.4	0.1	0.4	-0.9
Diabetes (mother)	0.7	0.9	3.4	0.3	1.8	0.4	0.5	0.1	-1.2
Severe depression (siblings)	0.8	0.9	4.1	0.0	-2.0	-0.6	0.2	-0.3	0.8
Pack years adult smoking proportion	0.4	0.6	1.9	0.9	0.1	1.4	0.2	-0.5	0.8
Impedance of leg (right)	0.5	2.5	6.5	2.4	0.6	0.0	2.5	1.4	0.5
Leg fat-free mass (left)	0.7	3.8	19.1	-1.6	-0.0	-4.4	-1.0	0.1	-0.2
Trunk fat percentage	0.3	1.1	4.4	-0.9	2.1	0.1	1.0	-0.3	-0.6
Hand grip strength (right)	0.9	2.5	10.7	3.3	-1.8	-0.2	-0.2	1.0	-0.1
Townsend deprivation index at recruitment	1.0	1.4	3.4	1.1	1.9	1.6	0.6	-0.7	0.6
Current tobacco smoking	0.4	0.6	1.7	0.4	-0.4	-0.0	1.2	-1.3	0.2
Average weekly fortified wine intake	0.6	0.6	1.8	0.2	1.3	0.9	0.4	0.1	1.0
Maternal smoking around birth	1.2	1.7	4.1	1.7	0.0	1.8	2.0	0.5	0.5
Fed-up feelings	1.2	2.1	4.4	-0.1	2.1	1.8	1.5	-0.5	-1.7
Frequency of unenthusiasm / disinterest in last 2 weeks	0.7	0.9	2.2	-1.4	0.4	-0.3	-0.0	-1.5	0.9
Relative age voice broke	0.5	0.8	2.9	0.6	0.6	-0.6	-0.9	1.7	0.3
Taking other prescription medications	0.9	1.4	7.3	0.3	2.7	0.3	0.7	-0.8	0.2
Age when periods started (menarche)	0.7	1.6	4.5	1.8	0.4	2.1	-0.9	0.6	-0.8
Bilateral oophorectomy (both ovaries removed)	1.2	1.4	4.1	-1.1	2.0	1.2	-0.8	0.8	0.5
Heel bone mineral density (BMD) T-score, automated (left)	0.4	0.8	1.4	-1.0	0.5	-1.2	-1.2	-0.8	0.4
Tinnitus: Yes, but not now, but have in the past	2.3	2.5	9.1	-0.6	1.5	-0.0	-1.5	3.0	-0.9
Qualifications: CSEs or equivalent	0.4	0.6	1.3	-0.3	0.7	0.4	-1.1	0.4	-1.1
Serious illness, injury or assault to yourself	0.9	1.1	2.8	1.7	-0.6	-0.5	0.7	0.1	-1.7
High blood pressure	0.3	0.9	1.8	-1.4	-0.1	-1.1	0.4	1.3	0.5
Hayfever, allergic rhinitis or eczema	0.5	1.1	2.1	0.9	0.9	1.5	1.4	0.4	-0.6
Multivitamins +/- minerals	1.2	1.5	7.0	1.0	0.4	-0.5	0.6	0.2	2.6
Stomach or abdominal pain in last month	0.7	0.9	3.9	-0.7	2.0	0.6	0.3	-0.5	0.3
Supplements: Glucosamine	0.7	0.9	3.3	-0.2	0.3	-1.1	-1.8	0.3	-0.7
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.7	0.0	-1.3	0.3	0.3	-0.4	0.3
Medication: Atenolol	1.4	1.8	4.6	-0.9	-2.1	-1.5	1.3	0.8	0.8
Medication: Levothyroxine sodium	0.1	0.2	0.4	0.6	0.4	-0.1	0.4	0.4	-0.4
Sitting height	1.0	7.0	37.0	-1.4	-0.5	-6.1	-0.7	1.6	0.3
Chronic bronchitis/emphysema (father)	1.1	1.2	3.7	-0.2	1.8	-0.7	-1.9	0.2	-0.0
High blood pressure (mother)	0.5	0.7	1.3	-0.4	-1.1	-0.6	-0.4	0.8	-1.1
Body mass index (BMI)	0.5	2.0	5.2	-2.3	1.6	-0.2	-0.3	-1.1	-1.8
Impedance of leg (left)	0.6	3.1	8.0	2.7	0.5	0.2	2.8	1.8	-0.0
Leg predicted mass (left)	0.7	3.6	18.3	-1.5	0.0	-4.3	-1.0	0.2	-0.3
Trunk fat mass	0.3	1.3	2.5	-1.5	1.5	-1.6	0.6	-0.2	-0.5
Waist circumference	0.7	2.5	5.6	-1.9	1.4	-2.4	0.2	-0.9	-1.7
Number of incorrect matches in round	0.7	1.1	3.3	-0.5	1.0	1.8	0.7	1.2	-0.0
Past tobacco smoking	0.4	0.8	2.5	0.1	-0.0	0.3	0.5	1.6	1.3
Alcohol usually taken with meals	0.0	0.1	0.3	-0.1	-0.5	-0.1	0.0	-0.1	0.2
Nervous feelings	0.5	1.0	2.9	-0.5	0.2	1.2	-0.0	1.1	1.7
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.7	1.9	0.5	0.6	1.4	0.6	-0.6	0.8
Hearing difficulty/problems with background noise	0.3	0.5	1.2	-0.8	-0.3	0.7	-0.1	-0.7	1.1
Hair/balding pattern: Pattern 2	0.5	0.7	2.7	-1.0	-0.0	0.5	0.3	-0.1	-1.6
Had menopause	0.2	0.3	0.7	0.8	0.8	0.3	0.5	0.3	0.0
Had other major operations	0.8	0.9	4.5	0.6	0.7	2.1	0.5	0.2	-0.2
Forced vital capacity (FVC)	1.0	4.0	11.6	2.8	0.7	-3.4	-0.2	1.8	-0.9
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.6	2.4	-0.4	0.8	-1.5	-0.2	-0.5	0.2
Ever unenthusiastic/disinterested for a whole week	0.5	0.7	2.4	-0.1	1.6	1.0	0.5	-0.3	0.4
Qualifications: None of the above	1.0	2.1	4.7	-2.2	1.7	1.4	-1.1	1.0	-1.0
Financial difficulties in last 2 years	0.8	1.1	2.3	-0.8	0.6	-1.2	-1.5	0.7	1.3
Mouth/teeth dental problems	0.3	0.4	1.1	-0.6	-0.3	1.1	-0.9	-0.5	-0.1
Heart attack	0.4	0.5	1.3	-0.5	0.1	0.6	1.1	-1.0	-0.5
Allergy	0.3	0.6	2.1	-0.5	-1.4	-0.5	-1.0	-0.4	0.2
Pain all over the body in last month	1.1	1.2	2.7	1.5	1.6	-0.8	0.4	0.5	1.1
Diabetes (self-reported)	1.5	2.3	5.8	-2.4	0.7	-2.0	-1.5	-0.9	-0.6
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	4.1	0.6	2.0	1.4	-0.1	-0.2	0.9
Medication: Ramipril	1.5	1.9	4.8	-1.7	-1.5	-2.2	-1.1	-0.0	0.1
Medication: Simvastatin	0.3	0.5	1.4	-1.2	0.5	-0.5	-0.8	-0.3	0.5
Fluid intelligence score	0.6	1.3	3.6	1.4	-0.7	-1.9	-1.2	-0.3	-0.4
Illnesses of siblings	0.7	1.0	2.5	1.6	-0.2	1.5	-0.1	-0.5	-1.0
Neuroticism score	0.5	1.1	3.5	-0.3	1.3	1.9	0.8	-0.3	0.7
Weight	0.7	3.4	15.1	-1.9	0.6	-3.9	-0.3	0.0	-1.2
Impedance of arm (right)	0.4	1.8	6.8	2.6	-0.5	0.6	1.7	0.1	0.7
Arm fat percentage (right)	0.4	1.7	3.8	-1.2	1.9	0.6	0.8	-1.3	-1.5
Trunk fat-free mass	1.0	5.9	32.4	-1.3	-0.8	-5.7	-0.5	0.6	-0.7
Hip circumference	0.5	2.2	6.2	-1.2	1.0	-2.5	0.9	-0.5	-1.8
Time employed in main current job	0.4	0.5	1.1	-0.7	1.1	0.6	-0.7	-0.4	0.4
Alcohol intake versus 10 years previously	0.4	0.7	1.4	-0.4	0.8	-1.2	-0.6	1.1	0.5
Father’s age at death	0.9	1.2	4.6	-0.3	0.3	1.1	0.2	-2.1	-1.0
Worrier / anxious feelings	0.5	1.0	4.5	0.2	-0.5	2.1	0.5	0.0	0.8
Frequency of tiredness / lethargy in last 2 weeks	0.9	1.4	4.7	-0.2	2.2	-0.9	-0.1	-1.6	-0.4
Falls in the last year	0.3	0.4	0.9	-0.1	0.9	0.9	0.2	-0.7	-0.5
Hair/balding pattern: Pattern 3	0.4	0.5	1.8	-0.6	-0.2	0.4	-1.4	-0.0	0.9
Number of live births	0.4	0.6	2.2	-0.4	-1.1	0.2	-0.1	1.5	0.2
Forced expiratory volume in 1-second (FEV1)	1.0	3.3	7.6	2.5	0.1	-2.8	-0.0	2.3	-0.8
Pulse rate	0.3	0.5	2.7	-0.1	1.6	-0.1	-0.1	-0.4	-0.1
Happiness	0.3	0.4	0.8	0.2	0.5	0.9	0.9	-0.3	-0.6
Noisy workplace	0.8	1.0	2.3	-0.9	0.9	1.1	-0.5	-0.8	-1.5
Qualifications: A levels/AS levels or equivalent	0.3	0.7	2.2	1.5	-0.8	-0.3	-0.8	-0.1	0.6
Serious illness, injury or assault of a close relative in last 2 years	0.4	0.4	0.8	0.9	0.2	-0.4	0.7	0.5	-0.7
Mouth/teeth dental problems: Dentures	0.7	1.2	2.0	-1.2	1.3	-0.7	-1.4	-1.1	-0.3
Asthma	0.1	0.1	0.3	-0.3	0.5	0.0	0.2	-0.2	0.5
Medication: Ibuprofen (e.g. Nurofen)	0.7	0.9	2.6	0.5	0.9	1.3	1.6	-0.3	-0.2
Medication: Cholesterol lowering	0.6	1.0	3.2	0.4	0.4	-1.4	-0.1	-1.8	0.0
Depression (self-reported)	1.1	1.3	3.3	0.9	0.4	1.8	1.8	0.4	-0.7
Medication: Lansoprazole	0.8	0.9	3.8	-0.4	-0.7	1.9	0.7	-0.2	-0.4
Prospective memory result	0.7	0.9	3.1	-1.8	-0.6	-0.3	0.5	0.8	0.9
Lung cancer (father)	2.1	2.4	5.7	1.8	0.2	1.4	1.9	-0.0	-2.4
Illnesses of mother	0.3	0.4	1.5	0.0	0.1	-0.1	-1.2	-0.7	0.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	12.2	1.0	-0.0	-3.5	-0.8	1.2	-0.6
Pulse wave Arterial Stiffness index	0.8	0.9	1.7	-0.5	-0.3	-1.3	1.1	-0.5	-1.3
Impedance of arm (left)	0.4	1.7	5.7	2.4	0.1	0.8	1.4	0.2	1.4
Arm fat mass (right)	0.4	1.6	3.6	-1.8	1.9	-1.1	0.1	-0.3	-1.3
Trunk predicted mass	1.0	5.8	31.6	-1.2	-0.7	-5.6	-0.5	0.6	-0.7
Standing height	1.3	13.1	67.4	0.8	-2.1	-8.2	0.3	2.3	0.9
Length of working week for main job	0.4	0.5	1.8	-0.1	0.5	1.3	-0.5	-0.8	-0.2
Exposure to tobacco smoke at home	0.5	0.5	1.4	-0.3	-0.7	0.3	1.2	0.8	-0.7
Breastfed as a baby	0.9	1.2	2.6	-1.6	-0.1	-1.2	-0.5	-1.6	-0.4
Tense / ‘highly strung’	0.2	0.4	0.9	-1.0	-0.4	-0.0	0.7	0.4	0.8
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.4	1.3	-0.4	-0.3	1.1	-0.8	0.1	-0.0
Hair/balding pattern: Pattern 4	0.4	1.0	2.9	0.2	1.2	1.1	0.8	-1.7	0.3
Birth weight of first child	0.3	0.6	1.5	1.2	-0.5	-0.3	-1.0	0.2	-0.8
Peak expiratory flow (PEF)	1.1	2.6	5.5	1.4	-2.0	-2.3	1.0	1.4	-1.2
Pulse wave reflection index	0.9	1.1	1.8	1.1	0.7	1.2	1.2	-0.3	-1.4
Ever highly irritable/argumentative for 2 days	0.7	0.8	2.2	-0.9	1.5	-0.4	0.2	-0.9	0.9
Loud music exposure frequency	0.2	0.2	1.0	0.1	-0.2	-0.3	-0.4	0.3	1.0
Qualifications: O levels/GCSEs or equivalent	0.9	1.5	4.0	2.0	-1.2	-1.7	0.6	-0.2	0.4
Mouth/teeth dental problems: Bleeding gums	1.9	2.4	4.8	2.2	-0.6	0.5	2.2	1.9	-0.9
Blood clot in the leg (DVT)	0.5	0.6	1.9	-0.7	0.5	-1.4	-0.7	0.9	-0.0
Medication: Paracetamol	0.4	0.7	2.5	-0.6	1.6	-0.2	-0.9	-0.0	-0.8
Headache pain in last month	0.5	0.9	2.1	0.9	1.1	0.0	-0.6	1.5	-0.9
Medication for cholesterol, blood pressure or diabetes	0.3	0.5	1.2	-0.1	0.1	0.6	-0.8	1.0	-1.1
Glaucoma (self-reported)	1.6	1.9	4.0	1.0	-1.6	-0.1	1.7	-0.8	-2.0
Gout (self-reported)	0.6	0.9	2.8	-0.5	-1.0	-0.7	1.7	0.6	0.6
Hypothyroidism/myxoedema (self-reported)	0.2	0.4	1.2	1.1	-0.5	0.3	0.5	0.6	-0.7
Medication: Amlodipine	0.1	0.1	0.5	-0.5	0.0	0.3	-0.2	-0.7	0.2
Medication: Ventolin 100micrograms inhaler	1.4	1.8	4.1	-1.5	-0.8	-2.0	-1.1	-0.9	1.4
Birth weight	0.4	0.8	1.4	0.9	0.6	-1.2	1.0	1.0	-0.6
Chronic bronchitis/emphysema (mother)	0.7	0.8	2.5	0.2	0.3	0.5	1.6	-0.9	-1.1
High blood pressure (siblings)	0.6	0.8	1.9	-1.0	-1.4	-1.3	-0.2	0.5	-0.1
Forced vital capacity (FVC), Best measure	0.9	3.4	16.2	1.6	-0.2	-4.0	-0.8	0.9	0.0
Body fat percentage	0.4	1.5	5.2	-1.2	2.3	0.3	0.8	-0.5	-1.1
Leg fat percentage (right)	0.6	2.3	6.1	-1.4	2.5	0.4	1.4	-0.8	-1.6
Arm fat-free mass (right)	0.9	4.7	22.7	-1.9	0.3	-4.8	-0.6	1.0	-0.8
Exposure to tobacco smoke outside home	0.8	1.1	2.1	-0.7	1.2	-1.3	-0.9	-0.6	1.5
Comparative body size at age 10	0.3	0.9	2.0	-0.8	0.2	0.5	-1.3	-0.8	-1.4
Number of full brothers	0.3	0.3	0.9	0.1	-0.4	0.5	-0.5	1.0	0.6
Worry too long after embarrassment	0.8	1.4	2.6	-1.3	1.2	1.4	-1.6	0.2	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.4	0.5	2.1	0.5	0.6	1.5	0.3	0.7	-0.1
Wheeze or whistling in the chest in last year	0.8	1.4	3.2	-1.3	0.7	1.8	-1.2	-1.2	-0.3
Number of children fathered	0.9	1.0	5.0	0.1	-0.3	2.2	-0.4	0.6	-0.7
Reason for reducing amount of alcohol drunk: Health precaution	1.1	1.3	4.9	0.3	2.2	1.7	-0.2	-0.1	0.2
Age at first live birth	1.0	1.9	3.6	-1.0	-1.9	-1.9	-1.4	-0.1	1.1
Pulse wave peak to peak time	0.6	0.7	1.6	0.8	0.0	0.9	-1.0	0.6	1.3
Health satisfaction	0.8	1.0	3.0	-0.6	1.4	-0.9	1.7	-0.1	0.4
Shortness of breath walking on level ground	0.7	0.8	3.8	0.3	-0.7	-0.6	2.0	-0.2	0.2
Qualifications: College or University degree	0.4	1.4	5.8	2.4	-1.1	-0.0	-1.0	-0.5	-0.5
Eye problems/disorders: None of the above	1.1	1.3	3.8	-1.1	-0.4	-0.7	-1.0	2.0	-1.0
Mouth/teeth dental problems: Loose teeth	1.0	1.2	3.9	-0.6	-0.1	-0.2	1.4	-0.7	2.0
Emphysema/chronic bronchitis	1.0	1.2	3.0	1.1	1.2	-0.1	1.1	1.7	0.5
Medication for pain relief, constipation, heartburn	0.3	0.4	1.5	1.0	-1.2	0.1	0.0	0.3	-0.1
Neck or shoulder pain in last month	0.4	0.6	1.5	-0.2	0.5	0.4	0.7	1.2	-1.0
Medication: Blood pressure	0.3	0.6	2.6	-0.7	0.3	-0.5	-0.2	0.3	1.6
Angina (self-reported)	0.3	0.4	1.0	-0.2	0.7	0.3	0.5	1.0	0.8
Migraine (self-reported)	1.4	1.7	4.5	-0.7	0.8	-0.3	-2.1	0.2	-2.1
Medication: Ibuprofen	0.2	0.2	0.6	-0.0	0.7	0.2	0.8	0.4	-0.2
Medication: Allopurinol	0.7	0.9	2.6	-0.2	-0.6	-1.1	1.0	0.7	1.6
Medication: Omeprazole	0.6	0.7	2.4	0.1	-0.3	-0.6	0.5	-1.1	1.5
Medication: Seretide 50 evohaler	0.1	0.2	0.4	-0.6	-0.0	0.0	-0.5	0.2	0.4
Mean time to correctly identify matches	0.8	1.6	3.8	-1.9	1.3	1.2	-1.2	-1.0	-0.3
Heart disease (mother)	0.7	0.8	2.1	1.1	-0.6	0.0	1.5	0.8	0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.2	1.5	3.2	1.4	-0.5	1.8	1.4	0.1	1.2
Whole body fat mass	0.4	1.6	3.6	-1.8	1.9	-1.4	0.3	-0.1	-0.8
Leg fat mass (right)	0.5	1.8	3.5	-1.9	1.8	-1.4	0.6	-0.3	-1.3
Arm predicted mass (right)	1.0	4.9	23.8	-1.7	0.4	-4.9	-0.6	1.3	-0.9
Pulse rate, automated reading	0.4	1.1	2.3	1.5	1.4	0.9	-0.1	-1.0	0.7
Alcohol intake frequency.	2.1	4.8	11.0	-3.3	0.6	-1.7	-2.3	1.9	-2.4
Comparative height size at age 10	1.6	8.8	44.9	-0.3	-1.7	-6.7	1.8	0.1	1.3
Number of full sisters	1.5	1.8	4.2	0.7	1.8	2.0	-1.5	0.7	0.5
Suffer from ‘nerves’	1.3	2.0	6.3	0.7	1.4	2.5	0.6	0.3	1.6
Overall health rating	0.3	0.7	1.8	-0.8	-0.2	-0.2	1.3	-1.1	0.9
Chest pain or discomfort	0.6	0.9	2.7	-1.2	-0.4	-0.5	0.9	-0.3	1.6
Had major operations	1.4	1.6	3.6	1.9	1.4	1.4	0.8	-0.5	1.1
Age at last live birth	2.5	3.7	7.5	-2.2	-0.5	-2.7	-2.4	0.2	1.9
Family relationship satisfaction	0.6	0.7	2.2	0.1	0.2	0.3	0.8	-1.2	1.5
Leg pain on walking	1.2	1.5	6.0	0.2	2.4	-0.3	-0.9	0.8	-1.1
Qualifications: NVQ or HND or HNC or equivalent	0.2	0.2	0.9	0.3	0.4	0.6	-0.1	-0.9	0.2
Commuting to job workplace: Car/motor vehicle	1.0	1.2	3.0	-0.7	-1.7	-0.9	-0.6	-0.1	-1.5
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	2.8	-1.0	-1.7	-1.1	0.3	-0.6	0.6
Medication: Aspirin	1.1	1.5	3.8	-1.9	-1.3	-1.7	-0.5	0.3	0.3
Supplements: Vitamin C	0.5	0.6	1.7	-0.3	-0.9	0.8	-0.5	0.6	-1.3
Knee pain experienced in last month	0.8	1.3	2.7	-1.2	1.6	-1.3	-1.0	-0.6	-0.6
Hypertension (Self-reported)	0.3	0.9	2.4	-0.7	-0.1	-1.1	0.9	1.5	0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.5	0.6	1.6	-0.4	0.7	1.2	0.3	0.3	-1.0
Illnesses of father: Heart disease	0.1	0.2	0.9	-0.0	-0.4	-0.2	0.9	-0.1	-0.4
Illnesses of siblings: Diabetes	0.8	1.0	3.4	-0.5	1.2	-1.8	-0.5	0.2	0.9
Smoking status: Previous	0.6	0.8	3.2	0.2	0.2	-0.1	-0.5	-1.8	-1.2
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.8	12.9	1.5	-2.6	-3.6	-0.6	0.2	0.5
Whole body fat-free mass	0.9	5.0	26.4	-1.4	-0.3	-5.1	-0.7	0.4	-0.7
Leg fat-free mass (right)	0.6	3.4	17.2	-1.3	-0.4	-4.2	-0.9	0.4	-0.4
Arm fat percentage (left)	0.5	1.9	5.4	-1.6	2.3	0.5	0.5	-1.1	-1.3
Average weekly red wine intake	1.2	1.8	6.4	2.5	-0.8	-0.1	1.5	0.4	-1.1
Handedness (chirality/laterality): Left-handed	1.1	1.3	3.0	-0.6	1.0	-1.3	-1.7	1.1	0.7
Mood swings	0.8	1.4	3.6	-0.4	0.5	1.9	1.9	-1.0	-0.2
Loneliness, isolation	0.6	0.9	1.6	-1.1	0.6	1.0	-0.9	-0.6	1.2
Long-standing illness, disability or infirmity	0.4	0.6	0.8	-0.4	0.9	-0.9	0.9	-0.6	-0.9
Ever had bowel cancer screening	1.1	1.2	4.2	-0.4	-0.8	-0.9	-2.0	1.1	0.5
Diabetes diagnosed by doctor	1.6	2.7	5.8	-2.4	1.1	-1.9	-1.3	-1.8	-0.7
Ever had stillbirth, spontaneous miscarriage or termination	0.5	0.6	1.2	-0.0	-0.3	-1.0	-0.9	1.1	-0.6
Friendships satisfaction	0.7	0.9	3.1	-0.0	-0.0	1.2	-0.9	-0.2	1.8
Qualifications: nursing, teaching	0.7	1.1	1.7	0.8	1.1	-1.3	-1.2	-0.8	-1.0
Commuting to job workplace: Walk	0.9	0.9	2.8	-0.2	1.0	-0.3	-0.8	-1.1	1.7
Eye problems/disorders: Cataract	0.3	0.3	1.0	0.3	1.0	0.4	-0.7	-0.2	0.0
Mouth/teeth dental problems: Mouth ulcers	0.3	0.5	1.9	1.4	0.6	-0.0	0.2	-0.7	0.2
Medication for cholesterol	1.4	2.1	6.7	0.6	-0.5	-0.8	-2.0	0.9	2.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.1	1.3	3.3	1.8	1.3	1.5	0.5	-0.5	0.4
Back pain experienced in last month	1.2	1.7	3.5	1.8	1.5	-0.9	0.7	1.9	-0.5
Mineral and other dietary supplements	0.6	0.7	3.6	-1.9	-0.0	0.0	-0.2	-0.9	-0.1
Breast cancer (self-reported)	2.8	3.4	13.8	3.7	-1.1	1.4	1.7	0.3	-0.6
Asthma (self-reported)	0.1	0.2	0.5	-0.2	0.7	0.4	0.4	0.0	0.7
Osteoporosis (self-reported)	0.6	0.8	1.9	-0.7	0.9	0.9	-1.4	0.9	0.1
Osteoarthritis (self-reported)	1.5	1.9	5.5	0.5	2.2	-0.6	0.4	-0.1	-2.3
Medication: Aspirin	0.7	0.9	2.1	-1.4	-1.2	-1.3	-0.3	0.4	0.5
Medication: Gliclazide	1.0	1.1	2.9	-1.7	0.6	-0.5	-1.5	-0.1	1.0
Illnesses of father: None of the above (group 1)	0.2	0.2	0.9	0.4	-0.1	0.2	0.2	0.1	0.9
Smoking status: Current	0.2	0.4	1.3	0.1	-0.6	-0.1	1.1	-0.8	0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.6	1.4	3.4	1.5	0.9	1.0	0.8	1.8	-0.4
Whole body water mass	0.9	5.1	27.1	-1.5	-0.2	-5.2	-0.8	0.5	-0.7
Leg predicted mass (right)	0.6	3.4	17.4	-1.3	-0.3	-4.2	-0.9	0.4	-0.4
Arm fat mass (left)	0.4	1.8	3.5	-1.9	1.7	-1.4	0.3	-0.4	-1.5
Number of self-reported non-cancer illnesses	0.3	0.5	2.0	-0.3	1.4	-0.9	-0.4	-0.2	0.2
Average weekly champagne plus white wine intake	0.6	0.8	1.5	1.1	-1.2	-1.0	0.2	-0.1	0.9
Miserableness	1.0	1.8	4.5	-0.5	2.1	0.7	0.3	-1.9	-1.4
Guilty feelings	0.7	1.0	3.8	-0.4	1.9	1.2	0.2	-0.2	0.8
Wears glasses or contact lenses	0.9	1.1	3.0	0.1	-1.1	1.7	-0.3	-1.1	-1.0
Ever taken oral contraceptive pill	0.9	0.9	1.9	0.4	-1.4	-0.5	-0.5	-1.3	1.1
Hearing aid user	0.7	0.8	2.7	-1.6	1.1	-0.6	0.0	-0.3	-0.7
Mother’s age at death	0.2	0.3	0.7	-0.5	0.5	0.1	-0.1	-0.5	0.8
Financial situation satisfaction	0.8	1.0	3.4	0.0	0.4	0.7	1.3	1.8	0.3
Tinnitus: Yes, now most or all of the time	0.1	0.1	0.2	0.5	0.1	0.2	0.2	-0.1	0.4
Commuting to job workplace: Public transport	1.5	1.8	3.7	1.5	1.4	0.8	1.4	-0.7	1.9
Eye problems/disorders: Glaucoma	1.1	1.3	2.8	1.1	-0.6	0.6	1.2	-1.4	-1.7
Medication: Blood pressure	0.5	0.9	2.8	-0.8	-0.3	0.2	1.3	-0.4	-1.7
Pain type(s) experienced in last month: Hip pain	0.7	0.9	3.6	0.5	0.5	0.3	1.1	-0.2	-1.9
Supplements: Fish oil (including cod liver oil)	1.6	2.1	8.5	2.9	0.6	0.5	1.6	0.1	1.0
High cholesterol (Self-reported)	0.3	0.6	1.5	0.1	-0.1	0.3	0.9	-1.0	1.2
Medication: Bendroflumethiazide	0.2	0.3	0.8	-0.6	0.7	0.9	-0.3	-0.4	-0.3
Medication: Paracetamol	0.5	0.7	2.1	-0.5	1.5	-0.1	-1.1	0.3	-0.8
Medication: Lisinopril	0.4	0.6	1.1	-1.0	0.8	-1.0	0.6	0.6	-0.1
Medication: Atorvastatin	0.5	0.6	1.7	0.5	0.4	1.1	1.3	-0.4	-0.3
Illnesses of father: High blood pressure	1.0	1.2	3.8	-0.1	-0.6	-0.2	-1.1	1.4	-1.9
Alcohol drinker status: Never	1.1	1.3	4.2	-0.4	1.9	0.1	0.2	2.0	-0.2
Ever smoked	0.5	1.0	3.4	-0.2	-0.7	-1.0	-0.0	-1.8	-0.9
Basal metabolic rate	0.8	4.7	24.7	-1.5	0.1	-5.0	-0.6	0.5	-0.7
Leg fat percentage (left)	0.6	2.3	6.0	-1.3	2.4	0.4	1.5	-0.6	-1.9
Arm fat-free mass (left)	0.8	4.1	20.6	-1.5	0.3	-4.5	-0.3	0.9	-0.9
Number of operations (self-reported)	1.8	2.7	7.9	2.1	1.3	2.8	1.3	0.1	-0.5
Average weekly beer plus cider intake	0.4	0.6	1.6	-0.3	0.3	-1.1	1.3	0.2	-0.5
Irritability	1.2	2.0	4.0	0.7	2.0	1.8	1.8	-0.6	0.7
Risk taking	0.4	0.6	1.3	0.8	0.9	0.2	-0.3	-0.7	-1.1
Ever had prostate specific antigen (PSA) test	0.6	0.7	1.3	1.0	-1.1	-0.7	0.8	0.4	0.8
Fractured/broken bones in last 5 years	0.4	0.6	1.6	-0.1	0.7	0.8	-1.3	0.8	0.3
Age started oral contraceptive pill	1.2	1.5	5.3	-2.3	0.6	-1.0	-1.5	-0.5	0.2
Diastolic blood pressure, automated reading	0.8	2.5	7.6	-2.8	2.1	-0.2	-1.0	-1.2	0.9
Ever depressed for a whole week	1.0	1.2	3.1	-0.4	1.3	1.8	-0.9	0.1	1.2
Unable to work because of sickness or disability	0.5	0.6	1.7	0.1	-1.0	0.1	1.3	-0.3	0.9
Commuting to job workplace: Cycle	0.5	0.6	1.8	1.4	0.4	-0.2	-0.1	-0.3	-1.2
Myopia	0.5	0.7	2.0	-0.7	-0.7	-0.0	-1.4	1.1	-0.4
Vascular/heart problems diagnosed by doctor	0.4	1.1	2.2	1.4	0.3	0.8	-0.8	-1.5	-0.9
Cholesterol lowering medication	0.2	0.3	0.8	-0.9	-0.4	0.0	0.7	-0.1	0.2
Medication: Omeprazole (e.g. Zanprol)	0.7	0.8	2.5	-0.4	-0.2	-0.6	0.4	-1.4	1.6
Pain experienced in last month	1.0	1.7	7.0	-0.9	-2.6	0.6	0.5	-1.0	0.9
Supplements: Calcium	1.2	1.3	2.9	1.7	1.0	0.0	1.3	1.4	-0.6
Basal cell carcinoma (self-reported)	0.4	0.4	0.8	-0.7	0.0	-0.2	-0.9	-0.8	0.7
Heart attack/myocardial infarction (self-reported)	0.3	0.3	0.8	-0.4	0.2	0.5	0.9	-0.7	-0.6
Deep venous thrombosis (DVT) (self-reported)	0.6	0.7	1.5	-0.9	0.5	-0.9	-0.7	1.2	0.6
Heart disease (siblings)	1.3	1.6	4.4	-2.1	-1.3	-1.8	0.2	0.1	-0.3
Alcohol drinker status: Previous	0.8	0.9	2.6	-1.6	0.6	0.9	-0.3	0.4	-1.1
Pack years of smoking	0.4	0.5	2.1	0.2	0.4	1.4	-0.1	-0.7	0.7
Impedance of whole body	0.5	2.7	8.1	2.9	-0.1	1.0	2.3	1.1	0.8
Leg fat mass (left)	0.5	1.8	3.6	-1.8	1.9	-1.3	0.5	-0.1	-1.5
Arm predicted mass (left)	0.8	4.3	21.1	-1.6	0.2	-4.6	-0.2	0.8	-1.2