Hub : Genes

COL12A1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 CommonMind Brain Pre-frontal Cortex 0.0590 0.0200 3.5e-05 0.022 0.043 0.020 0.040 0.018 0.00097 5.7e-06 0.0015 1.2e-05 0.0028
2 GTEx Testis 0.4570 0.1010 9.7e-05 -0.004 NA -0.005 NA 0.003 0.54000 NA 0.6700 NA 0.2300
3 METSIM Adipose 0.0366 0.0159 1.6e-03 0.006 0.020 0.010 0.017 0.003 0.03900 5.1e-04 0.0110 1.3e-03 0.0960
4 ROSMAP Brain Pre-frontal Cortex 0.0644 0.0284 3.4e-03 0.023 0.008 0.003 0.012 0.006 0.00048 2.5e-02 0.1000 8.5e-03 0.0460
5 TCGA Kidney Renal Clear Cell Carcinoma 0.0792 0.0352 7.7e-03 0.000 0.004 0.002 NA 0.001 0.29000 1.0e-01 0.1700 NA 0.2400
6 TCGA Uterine Corpus Endometrial Carcinoma 0.2220 0.0940 4.4e-03 0.038 -0.011 -0.010 NA 0.033 0.03200 9.5e-01 0.7800 NA 0.0420

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6
Bipolar Disorder (2018) 0.7 1.0 2.4 -0.9 -0.8 -0.8 -0.6 -1.6 -1.1
Bipolar Disorder or Schizophrenia 0.3 0.7 1.8 -0.3 0.3 1.0 0.0 -1.1 -1.4
Depressed Affect (Nagel 2018) 0.6 1.3 2.8 -1.7 0.5 1.6 -0.3 -0.9 -1.1
Depression (Nagel 2018) 0.7 1.1 2.4 -1.6 0.8 -0.2 -1.5 -0.9 0.4
Intelligence (Savage-Jansen 2018) 0.5 1.7 4.0 1.5 -0.8 -2.0 -1.7 0.2 -0.3
Neuroticism (Nagel 2018) 0.4 1.0 3.6 -1.4 0.5 1.9 -0.5 -0.2 0.1
Schizophrenia (2018) 0.4 0.9 3.6 0.4 1.1 1.9 0.5 -0.2 0.0
Schizophrenia vs Biploar Disorder 0.2 0.2 0.5 0.4 0.6 0.7 -0.2 0.4 -0.1
Worry (Nagel 2018) 1.0 2.1 8.2 0.3 0.3 2.9 0.5 1.2 1.5
Alzheimer’s Disease (in mother) 0.3 0.3 0.9 -0.6 -0.2 0.0 -0.3 0.9 0.6
Alzheimer’s Disease (in father) 0.7 0.8 4.0 -0.2 0.3 0.4 0.7 -0.3 -2.0
Alzheimer’s Disease (including proxy) 0.3 0.4 1.4 -0.6 -0.2 -0.1 0.3 1.2 -0.6
Crohns Disease (2017) 0.2 0.5 1.7 -0.8 -0.8 0.4 -0.3 -1.3 -0.1
Irritable Bowel Disease (IBD) 0.2 0.5 1.6 0.6 -0.1 0.4 0.3 -1.3 -0.9
Ulcerative Colitis (UC) 0.3 0.6 1.7 1.3 1.1 0.4 0.4 -0.2 -0.6
Major Depression (MDD) 0.4 0.5 1.7 -0.1 0.7 0.3 -0.0 -0.8 1.3
Reaction Time 0.5 0.9 1.6 -1.0 1.3 0.3 -0.9 -1.1 -0.8
Verbal and Numeric Reasoning (VNR) 0.8 1.8 6.1 0.9 -1.2 -1.3 -2.5 0.8 0.6
Breast Cancer 0.6 1.4 5.7 -1.0 0.2 -0.0 -2.4 1.3 -0.3
Ovarian Cancer 1.1 1.4 3.6 -0.8 -1.9 -1.0 -0.9 -0.5 -1.4
Prostate Cancer 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0 0.0
Age at First Birth 1.2 1.8 5.1 -1.8 -0.8 -2.2 0.2 -0.8 -0.9
Bipolar Disorder (2011) 1.3 1.2 3.8 -1.6 0.0 -2.0 -1.0 0.0 0.0
Body Mass Index (BMI) (2010) 1.0 1.4 3.6 1.0 1.0 1.9 1.2 -1.2 0.0
Coronary Artery Disease (CAD) 0.6 0.7 1.9 0.2 1.4 -0.6 -0.5 0.6 -1.1
Crohns Disease (2012) 0.5 0.9 2.5 -1.4 -0.8 0.1 0.0 -1.6 -0.3
Mean Putamen Volume 1.4 1.6 2.8 1.6 1.3 1.7 1.3 0.9 -0.5
Fasting Glucose 1.3 1.6 3.0 1.7 1.2 1.4 1.1 -1.2 0.6
HbA1C 1.1 1.2 3.6 0.4 -1.9 -1.0 0.2 -1.6 0.3
HDL Cholesterol 0.5 0.8 2.8 0.2 0.7 1.0 -0.3 0.8 -1.7
LDL Cholesterol 0.7 1.1 5.3 0.0 0.8 2.3 -0.4 -0.2 0.5
Lupus 0.9 1.3 4.3 0.1 1.8 0.4 -0.1 -2.1 0.0
Neuroticism (2016) 0.5 0.7 2.3 -0.7 -0.6 -1.0 1.5 -0.3 0.0
Primary Biliary Cirrhosis 0.2 0.3 0.7 0.7 -0.2 0.8 0.8 0.1 0.0
Rheumatoid Arthritis 1.5 2.1 5.5 -0.7 0.9 0.4 1.2 -2.0 -2.3
Schizophrenia (2014) 0.3 0.6 2.5 -0.1 0.7 1.6 -0.0 0.3 -0.7
Triglycerides 0.4 0.6 1.4 1.2 0.3 0.3 1.1 -0.7 0.5
Type 2 Diabetes (T2D) (2012) 0.6 0.6 1.1 0.8 1.1 0.8 0.7 -0.9 0.4
Ulcerative Colitis 0.4 0.6 2.4 1.6 0.3 0.6 0.8 0.0 -0.2
Blood Eosinophil Count 0.5 3.5 9.1 -2.5 1.1 -1.6 -3.0 -0.9 0.9
Blood Platelet Count 0.3 3.3 8.8 -0.4 0.8 -0.3 -2.8 1.4 3.0
Blood Red Count 0.2 1.6 3.2 -1.4 1.8 -1.6 -0.0 -0.9 0.8
Blood White Count 0.4 2.8 9.2 -0.8 -0.2 -1.7 -1.1 -1.5 3.0
Heel T-Score 0.0 0.1 0.5 -0.3 -0.7 -0.2 -0.0 -0.2 0.4
BMI 0.4 2.4 6.2 -2.1 1.2 -0.2 1.0 -2.5 -1.1
Height 0.9 16.4 89.3 0.1 -2.5 -9.4 -0.6 1.0 1.3
Waist Hip Ratio (WHR) 0.6 2.8 7.8 -1.4 -1.5 -2.8 -1.6 -1.4 0.5
Systolic Blood Pressure 0.3 1.5 3.2 -1.8 -1.8 -1.2 0.7 -0.3 -0.5
Smoking Status 0.1 0.2 0.3 -0.4 -0.5 -0.2 -0.5 -0.5 -0.6
Allergy or Eczema 0.2 0.5 1.5 0.1 0.9 0.7 0.4 1.2 0.4
Cardiovascular Disease 0.4 1.5 3.6 -0.1 -1.6 -1.9 1.5 0.0 0.6
Hypothyroidism (self reported) 0.2 0.5 1.2 0.3 -1.1 -0.2 0.2 -0.7 -0.9
Respiratory disease 0.4 0.9 1.7 -0.9 1.3 0.1 -0.9 -0.9 1.2
Type 2 Diabetes (T2D) (2018) 2.0 3.8 7.6 -2.7 0.1 -2.8 -1.9 -1.8 -1.2
Lung FEV1/FVC ratio 0.1 0.8 3.1 -1.8 -0.4 0.1 -0.1 1.1 0.3
Lung FVC 0.1 0.5 1.6 1.1 0.1 0.6 -1.3 0.2 0.3
Neuroticism 0.5 1.1 4.6 -0.4 1.4 2.1 0.3 0.1 0.2
Chronotype (morning person) 0.6 1.3 2.9 -1.2 -1.7 0.6 -0.2 1.0 1.5
Hair Pigment 0.1 1.8 6.6 0.7 0.3 -1.3 2.6 1.3 -0.5
Tanning 0.2 2.6 4.8 -2.1 -2.2 -0.8 -1.5 -1.8 0.2
Hand grip strength (left) 0.4 1.1 6.1 2.5 -0.5 -0.2 -0.2 0.0 -0.6
Number of treatments/medications taken 0.3 0.5 1.6 0.2 1.2 -0.2 1.1 -0.3 -0.5
Average weekly spirits intake 1.0 1.2 2.7 0.6 1.5 -1.6 0.5 0.2 -1.2
Sensitivity / hurt feelings 0.3 0.5 1.9 -1.4 0.4 0.6 -0.5 -0.7 0.2
Frequency of depressed mood in last 2 weeks 0.6 0.9 2.5 -0.8 1.3 0.4 -0.4 -1.6 0.4
Hearing difficulty/problems: Yes 0.5 0.8 2.1 -0.9 0.6 1.1 0.3 -1.5 -0.2
Relative age of first facial hair 1.0 2.1 5.4 2.3 0.5 1.4 0.1 2.0 1.0
Other serious medical condition/disability diagnosed by doctor 0.9 1.2 3.7 -0.1 0.1 0.7 -1.2 -1.9 1.2
Ever used hormone-replacement therapy (HRT) 0.9 1.2 2.7 -0.1 1.2 0.8 1.4 -0.3 -1.6
Ever had hysterectomy (womb removed) 0.7 0.7 1.6 -0.7 1.3 -0.6 0.6 0.7 -1.1
Systolic blood pressure, automated reading 0.3 0.8 3.8 -1.9 0.6 0.7 -0.3 -0.6 0.1
Eye problems/disorders: Diabetes related eye disease 0.7 0.7 2.9 -0.6 0.6 -0.7 0.2 -1.7 0.3
Angina 0.4 0.5 1.3 -0.3 0.7 0.2 0.5 1.2 0.9
Medication for hormone replacement therapy 1.8 2.0 4.0 0.5 1.2 1.6 1.8 -0.2 -2.0
Vitamin and mineral supplements 0.1 0.2 0.3 -0.6 -0.3 0.0 -0.5 -0.1 -0.6
Supplements: Zinc 0.5 0.5 1.6 0.3 -1.3 -0.5 0.8 0.5 0.6
Medication: Co-codamol 0.7 0.8 3.3 1.0 1.8 -0.1 0.5 0.4 -0.2
Medication: Metformin 1.7 2.3 5.3 -2.3 1.5 -1.3 -1.4 -1.6 -0.7
Diabetes (father) 0.2 0.3 0.8 0.3 0.8 0.4 0.1 0.4 -0.9
Diabetes (mother) 0.7 0.9 3.4 0.3 1.8 0.4 0.5 0.1 -1.2
Severe depression (siblings) 0.8 0.9 4.1 0.0 -2.0 -0.6 0.2 -0.3 0.8
Pack years adult smoking proportion 0.4 0.6 1.9 0.9 0.1 1.4 0.2 -0.5 0.8
Impedance of leg (right) 0.5 2.5 6.5 2.4 0.6 0.0 2.5 1.4 0.5
Leg fat-free mass (left) 0.7 3.8 19.1 -1.6 -0.0 -4.4 -1.0 0.1 -0.2
Trunk fat percentage 0.3 1.1 4.4 -0.9 2.1 0.1 1.0 -0.3 -0.6
Hand grip strength (right) 0.9 2.5 10.7 3.3 -1.8 -0.2 -0.2 1.0 -0.1
Townsend deprivation index at recruitment 1.0 1.4 3.4 1.1 1.9 1.6 0.6 -0.7 0.6
Current tobacco smoking 0.4 0.6 1.7 0.4 -0.4 -0.0 1.2 -1.3 0.2
Average weekly fortified wine intake 0.6 0.6 1.8 0.2 1.3 0.9 0.4 0.1 1.0
Maternal smoking around birth 1.2 1.7 4.1 1.7 0.0 1.8 2.0 0.5 0.5
Fed-up feelings 1.2 2.1 4.4 -0.1 2.1 1.8 1.5 -0.5 -1.7
Frequency of unenthusiasm / disinterest in last 2 weeks 0.7 0.9 2.2 -1.4 0.4 -0.3 -0.0 -1.5 0.9
Relative age voice broke 0.5 0.8 2.9 0.6 0.6 -0.6 -0.9 1.7 0.3
Taking other prescription medications 0.9 1.4 7.3 0.3 2.7 0.3 0.7 -0.8 0.2
Age when periods started (menarche) 0.7 1.6 4.5 1.8 0.4 2.1 -0.9 0.6 -0.8
Bilateral oophorectomy (both ovaries removed) 1.2 1.4 4.1 -1.1 2.0 1.2 -0.8 0.8 0.5
Heel bone mineral density (BMD) T-score, automated (left) 0.4 0.8 1.4 -1.0 0.5 -1.2 -1.2 -0.8 0.4
Tinnitus: Yes, but not now, but have in the past 2.3 2.5 9.1 -0.6 1.5 -0.0 -1.5 3.0 -0.9
Qualifications: CSEs or equivalent 0.4 0.6 1.3 -0.3 0.7 0.4 -1.1 0.4 -1.1
Serious illness, injury or assault to yourself 0.9 1.1 2.8 1.7 -0.6 -0.5 0.7 0.1 -1.7
High blood pressure 0.3 0.9 1.8 -1.4 -0.1 -1.1 0.4 1.3 0.5
Hayfever, allergic rhinitis or eczema 0.5 1.1 2.1 0.9 0.9 1.5 1.4 0.4 -0.6
Multivitamins +/- minerals 1.2 1.5 7.0 1.0 0.4 -0.5 0.6 0.2 2.6
Stomach or abdominal pain in last month 0.7 0.9 3.9 -0.7 2.0 0.6 0.3 -0.5 0.3
Supplements: Glucosamine 0.7 0.9 3.3 -0.2 0.3 -1.1 -1.8 0.3 -0.7
Diverticular disease/diverticulitis (self-reported) 0.3 0.4 1.7 0.0 -1.3 0.3 0.3 -0.4 0.3
Medication: Atenolol 1.4 1.8 4.6 -0.9 -2.1 -1.5 1.3 0.8 0.8
Medication: Levothyroxine sodium 0.1 0.2 0.4 0.6 0.4 -0.1 0.4 0.4 -0.4
Sitting height 1.0 7.0 37.0 -1.4 -0.5 -6.1 -0.7 1.6 0.3
Chronic bronchitis/emphysema (father) 1.1 1.2 3.7 -0.2 1.8 -0.7 -1.9 0.2 -0.0
High blood pressure (mother) 0.5 0.7 1.3 -0.4 -1.1 -0.6 -0.4 0.8 -1.1
Body mass index (BMI) 0.5 2.0 5.2 -2.3 1.6 -0.2 -0.3 -1.1 -1.8
Impedance of leg (left) 0.6 3.1 8.0 2.7 0.5 0.2 2.8 1.8 -0.0
Leg predicted mass (left) 0.7 3.6 18.3 -1.5 0.0 -4.3 -1.0 0.2 -0.3
Trunk fat mass 0.3 1.3 2.5 -1.5 1.5 -1.6 0.6 -0.2 -0.5
Waist circumference 0.7 2.5 5.6 -1.9 1.4 -2.4 0.2 -0.9 -1.7
Number of incorrect matches in round 0.7 1.1 3.3 -0.5 1.0 1.8 0.7 1.2 -0.0
Past tobacco smoking 0.4 0.8 2.5 0.1 -0.0 0.3 0.5 1.6 1.3
Alcohol usually taken with meals 0.0 0.1 0.3 -0.1 -0.5 -0.1 0.0 -0.1 0.2
Nervous feelings 0.5 1.0 2.9 -0.5 0.2 1.2 -0.0 1.1 1.7
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.7 1.9 0.5 0.6 1.4 0.6 -0.6 0.8
Hearing difficulty/problems with background noise 0.3 0.5 1.2 -0.8 -0.3 0.7 -0.1 -0.7 1.1
Hair/balding pattern: Pattern 2 0.5 0.7 2.7 -1.0 -0.0 0.5 0.3 -0.1 -1.6
Had menopause 0.2 0.3 0.7 0.8 0.8 0.3 0.5 0.3 0.0
Had other major operations 0.8 0.9 4.5 0.6 0.7 2.1 0.5 0.2 -0.2
Forced vital capacity (FVC) 1.0 4.0 11.6 2.8 0.7 -3.4 -0.2 1.8 -0.9
Heel bone mineral density (BMD) T-score, automated (right) 0.3 0.6 2.4 -0.4 0.8 -1.5 -0.2 -0.5 0.2
Ever unenthusiastic/disinterested for a whole week 0.5 0.7 2.4 -0.1 1.6 1.0 0.5 -0.3 0.4
Qualifications: None of the above 1.0 2.1 4.7 -2.2 1.7 1.4 -1.1 1.0 -1.0
Financial difficulties in last 2 years 0.8 1.1 2.3 -0.8 0.6 -1.2 -1.5 0.7 1.3
Mouth/teeth dental problems 0.3 0.4 1.1 -0.6 -0.3 1.1 -0.9 -0.5 -0.1
Heart attack 0.4 0.5 1.3 -0.5 0.1 0.6 1.1 -1.0 -0.5
Allergy 0.3 0.6 2.1 -0.5 -1.4 -0.5 -1.0 -0.4 0.2
Pain all over the body in last month 1.1 1.2 2.7 1.5 1.6 -0.8 0.4 0.5 1.1
Diabetes (self-reported) 1.5 2.3 5.8 -2.4 0.7 -2.0 -1.5 -0.9 -0.6
Hayfever/allergic rhinitis (self-reported) 0.9 1.2 4.1 0.6 2.0 1.4 -0.1 -0.2 0.9
Medication: Ramipril 1.5 1.9 4.8 -1.7 -1.5 -2.2 -1.1 -0.0 0.1
Medication: Simvastatin 0.3 0.5 1.4 -1.2 0.5 -0.5 -0.8 -0.3 0.5
Fluid intelligence score 0.6 1.3 3.6 1.4 -0.7 -1.9 -1.2 -0.3 -0.4
Illnesses of siblings 0.7 1.0 2.5 1.6 -0.2 1.5 -0.1 -0.5 -1.0
Neuroticism score 0.5 1.1 3.5 -0.3 1.3 1.9 0.8 -0.3 0.7
Weight 0.7 3.4 15.1 -1.9 0.6 -3.9 -0.3 0.0 -1.2
Impedance of arm (right) 0.4 1.8 6.8 2.6 -0.5 0.6 1.7 0.1 0.7
Arm fat percentage (right) 0.4 1.7 3.8 -1.2 1.9 0.6 0.8 -1.3 -1.5
Trunk fat-free mass 1.0 5.9 32.4 -1.3 -0.8 -5.7 -0.5 0.6 -0.7
Hip circumference 0.5 2.2 6.2 -1.2 1.0 -2.5 0.9 -0.5 -1.8
Time employed in main current job 0.4 0.5 1.1 -0.7 1.1 0.6 -0.7 -0.4 0.4
Alcohol intake versus 10 years previously 0.4 0.7 1.4 -0.4 0.8 -1.2 -0.6 1.1 0.5
Father’s age at death 0.9 1.2 4.6 -0.3 0.3 1.1 0.2 -2.1 -1.0
Worrier / anxious feelings 0.5 1.0 4.5 0.2 -0.5 2.1 0.5 0.0 0.8
Frequency of tiredness / lethargy in last 2 weeks 0.9 1.4 4.7 -0.2 2.2 -0.9 -0.1 -1.6 -0.4
Falls in the last year 0.3 0.4 0.9 -0.1 0.9 0.9 0.2 -0.7 -0.5
Hair/balding pattern: Pattern 3 0.4 0.5 1.8 -0.6 -0.2 0.4 -1.4 -0.0 0.9
Number of live births 0.4 0.6 2.2 -0.4 -1.1 0.2 -0.1 1.5 0.2
Forced expiratory volume in 1-second (FEV1) 1.0 3.3 7.6 2.5 0.1 -2.8 -0.0 2.3 -0.8
Pulse rate 0.3 0.5 2.7 -0.1 1.6 -0.1 -0.1 -0.4 -0.1
Happiness 0.3 0.4 0.8 0.2 0.5 0.9 0.9 -0.3 -0.6
Noisy workplace 0.8 1.0 2.3 -0.9 0.9 1.1 -0.5 -0.8 -1.5
Qualifications: A levels/AS levels or equivalent 0.3 0.7 2.2 1.5 -0.8 -0.3 -0.8 -0.1 0.6
Serious illness, injury or assault of a close relative in last 2 years 0.4 0.4 0.8 0.9 0.2 -0.4 0.7 0.5 -0.7
Mouth/teeth dental problems: Dentures 0.7 1.2 2.0 -1.2 1.3 -0.7 -1.4 -1.1 -0.3
Asthma 0.1 0.1 0.3 -0.3 0.5 0.0 0.2 -0.2 0.5
Medication: Ibuprofen (e.g. Nurofen) 0.7 0.9 2.6 0.5 0.9 1.3 1.6 -0.3 -0.2
Medication: Cholesterol lowering 0.6 1.0 3.2 0.4 0.4 -1.4 -0.1 -1.8 0.0
Depression (self-reported) 1.1 1.3 3.3 0.9 0.4 1.8 1.8 0.4 -0.7
Medication: Lansoprazole 0.8 0.9 3.8 -0.4 -0.7 1.9 0.7 -0.2 -0.4
Prospective memory result 0.7 0.9 3.1 -1.8 -0.6 -0.3 0.5 0.8 0.9
Lung cancer (father) 2.1 2.4 5.7 1.8 0.2 1.4 1.9 -0.0 -2.4
Illnesses of mother 0.3 0.4 1.5 0.0 0.1 -0.1 -1.2 -0.7 0.7
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.6 12.2 1.0 -0.0 -3.5 -0.8 1.2 -0.6
Pulse wave Arterial Stiffness index 0.8 0.9 1.7 -0.5 -0.3 -1.3 1.1 -0.5 -1.3
Impedance of arm (left) 0.4 1.7 5.7 2.4 0.1 0.8 1.4 0.2 1.4
Arm fat mass (right) 0.4 1.6 3.6 -1.8 1.9 -1.1 0.1 -0.3 -1.3
Trunk predicted mass 1.0 5.8 31.6 -1.2 -0.7 -5.6 -0.5 0.6 -0.7
Standing height 1.3 13.1 67.4 0.8 -2.1 -8.2 0.3 2.3 0.9
Length of working week for main job 0.4 0.5 1.8 -0.1 0.5 1.3 -0.5 -0.8 -0.2
Exposure to tobacco smoke at home 0.5 0.5 1.4 -0.3 -0.7 0.3 1.2 0.8 -0.7
Breastfed as a baby 0.9 1.2 2.6 -1.6 -0.1 -1.2 -0.5 -1.6 -0.4
Tense / ‘highly strung’ 0.2 0.4 0.9 -1.0 -0.4 -0.0 0.7 0.4 0.8
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.4 1.3 -0.4 -0.3 1.1 -0.8 0.1 -0.0
Hair/balding pattern: Pattern 4 0.4 1.0 2.9 0.2 1.2 1.1 0.8 -1.7 0.3
Birth weight of first child 0.3 0.6 1.5 1.2 -0.5 -0.3 -1.0 0.2 -0.8
Peak expiratory flow (PEF) 1.1 2.6 5.5 1.4 -2.0 -2.3 1.0 1.4 -1.2
Pulse wave reflection index 0.9 1.1 1.8 1.1 0.7 1.2 1.2 -0.3 -1.4
Ever highly irritable/argumentative for 2 days 0.7 0.8 2.2 -0.9 1.5 -0.4 0.2 -0.9 0.9
Loud music exposure frequency 0.2 0.2 1.0 0.1 -0.2 -0.3 -0.4 0.3 1.0
Qualifications: O levels/GCSEs or equivalent 0.9 1.5 4.0 2.0 -1.2 -1.7 0.6 -0.2 0.4
Mouth/teeth dental problems: Bleeding gums 1.9 2.4 4.8 2.2 -0.6 0.5 2.2 1.9 -0.9
Blood clot in the leg (DVT) 0.5 0.6 1.9 -0.7 0.5 -1.4 -0.7 0.9 -0.0
Medication: Paracetamol 0.4 0.7 2.5 -0.6 1.6 -0.2 -0.9 -0.0 -0.8
Headache pain in last month 0.5 0.9 2.1 0.9 1.1 0.0 -0.6 1.5 -0.9
Medication for cholesterol, blood pressure or diabetes 0.3 0.5 1.2 -0.1 0.1 0.6 -0.8 1.0 -1.1
Glaucoma (self-reported) 1.6 1.9 4.0 1.0 -1.6 -0.1 1.7 -0.8 -2.0
Gout (self-reported) 0.6 0.9 2.8 -0.5 -1.0 -0.7 1.7 0.6 0.6
Hypothyroidism/myxoedema (self-reported) 0.2 0.4 1.2 1.1 -0.5 0.3 0.5 0.6 -0.7
Medication: Amlodipine 0.1 0.1 0.5 -0.5 0.0 0.3 -0.2 -0.7 0.2
Medication: Ventolin 100micrograms inhaler 1.4 1.8 4.1 -1.5 -0.8 -2.0 -1.1 -0.9 1.4
Birth weight 0.4 0.8 1.4 0.9 0.6 -1.2 1.0 1.0 -0.6
Chronic bronchitis/emphysema (mother) 0.7 0.8 2.5 0.2 0.3 0.5 1.6 -0.9 -1.1
High blood pressure (siblings) 0.6 0.8 1.9 -1.0 -1.4 -1.3 -0.2 0.5 -0.1
Forced vital capacity (FVC), Best measure 0.9 3.4 16.2 1.6 -0.2 -4.0 -0.8 0.9 0.0
Body fat percentage 0.4 1.5 5.2 -1.2 2.3 0.3 0.8 -0.5 -1.1
Leg fat percentage (right) 0.6 2.3 6.1 -1.4 2.5 0.4 1.4 -0.8 -1.6
Arm fat-free mass (right) 0.9 4.7 22.7 -1.9 0.3 -4.8 -0.6 1.0 -0.8
Exposure to tobacco smoke outside home 0.8 1.1 2.1 -0.7 1.2 -1.3 -0.9 -0.6 1.5
Comparative body size at age 10 0.3 0.9 2.0 -0.8 0.2 0.5 -1.3 -0.8 -1.4
Number of full brothers 0.3 0.3 0.9 0.1 -0.4 0.5 -0.5 1.0 0.6
Worry too long after embarrassment 0.8 1.4 2.6 -1.3 1.2 1.4 -1.6 0.2 -0.8
Seen a psychiatrist for nerves, anxiety, tension or depression 0.4 0.5 2.1 0.5 0.6 1.5 0.3 0.7 -0.1
Wheeze or whistling in the chest in last year 0.8 1.4 3.2 -1.3 0.7 1.8 -1.2 -1.2 -0.3
Number of children fathered 0.9 1.0 5.0 0.1 -0.3 2.2 -0.4 0.6 -0.7
Reason for reducing amount of alcohol drunk: Health precaution 1.1 1.3 4.9 0.3 2.2 1.7 -0.2 -0.1 0.2
Age at first live birth 1.0 1.9 3.6 -1.0 -1.9 -1.9 -1.4 -0.1 1.1
Pulse wave peak to peak time 0.6 0.7 1.6 0.8 0.0 0.9 -1.0 0.6 1.3
Health satisfaction 0.8 1.0 3.0 -0.6 1.4 -0.9 1.7 -0.1 0.4
Shortness of breath walking on level ground 0.7 0.8 3.8 0.3 -0.7 -0.6 2.0 -0.2 0.2
Qualifications: College or University degree 0.4 1.4 5.8 2.4 -1.1 -0.0 -1.0 -0.5 -0.5
Eye problems/disorders: None of the above 1.1 1.3 3.8 -1.1 -0.4 -0.7 -1.0 2.0 -1.0
Mouth/teeth dental problems: Loose teeth 1.0 1.2 3.9 -0.6 -0.1 -0.2 1.4 -0.7 2.0
Emphysema/chronic bronchitis 1.0 1.2 3.0 1.1 1.2 -0.1 1.1 1.7 0.5
Medication for pain relief, constipation, heartburn 0.3 0.4 1.5 1.0 -1.2 0.1 0.0 0.3 -0.1
Neck or shoulder pain in last month 0.4 0.6 1.5 -0.2 0.5 0.4 0.7 1.2 -1.0
Medication: Blood pressure 0.3 0.6 2.6 -0.7 0.3 -0.5 -0.2 0.3 1.6
Angina (self-reported) 0.3 0.4 1.0 -0.2 0.7 0.3 0.5 1.0 0.8
Migraine (self-reported) 1.4 1.7 4.5 -0.7 0.8 -0.3 -2.1 0.2 -2.1
Medication: Ibuprofen 0.2 0.2 0.6 -0.0 0.7 0.2 0.8 0.4 -0.2
Medication: Allopurinol 0.7 0.9 2.6 -0.2 -0.6 -1.1 1.0 0.7 1.6
Medication: Omeprazole 0.6 0.7 2.4 0.1 -0.3 -0.6 0.5 -1.1 1.5
Medication: Seretide 50 evohaler 0.1 0.2 0.4 -0.6 -0.0 0.0 -0.5 0.2 0.4
Mean time to correctly identify matches 0.8 1.6 3.8 -1.9 1.3 1.2 -1.2 -1.0 -0.3
Heart disease (mother) 0.7 0.8 2.1 1.1 -0.6 0.0 1.5 0.8 0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 1.2 1.5 3.2 1.4 -0.5 1.8 1.4 0.1 1.2
Whole body fat mass 0.4 1.6 3.6 -1.8 1.9 -1.4 0.3 -0.1 -0.8
Leg fat mass (right) 0.5 1.8 3.5 -1.9 1.8 -1.4 0.6 -0.3 -1.3
Arm predicted mass (right) 1.0 4.9 23.8 -1.7 0.4 -4.9 -0.6 1.3 -0.9
Pulse rate, automated reading 0.4 1.1 2.3 1.5 1.4 0.9 -0.1 -1.0 0.7
Alcohol intake frequency. 2.1 4.8 11.0 -3.3 0.6 -1.7 -2.3 1.9 -2.4
Comparative height size at age 10 1.6 8.8 44.9 -0.3 -1.7 -6.7 1.8 0.1 1.3
Number of full sisters 1.5 1.8 4.2 0.7 1.8 2.0 -1.5 0.7 0.5
Suffer from ‘nerves’ 1.3 2.0 6.3 0.7 1.4 2.5 0.6 0.3 1.6
Overall health rating 0.3 0.7 1.8 -0.8 -0.2 -0.2 1.3 -1.1 0.9
Chest pain or discomfort 0.6 0.9 2.7 -1.2 -0.4 -0.5 0.9 -0.3 1.6
Had major operations 1.4 1.6 3.6 1.9 1.4 1.4 0.8 -0.5 1.1
Age at last live birth 2.5 3.7 7.5 -2.2 -0.5 -2.7 -2.4 0.2 1.9
Family relationship satisfaction 0.6 0.7 2.2 0.1 0.2 0.3 0.8 -1.2 1.5
Leg pain on walking 1.2 1.5 6.0 0.2 2.4 -0.3 -0.9 0.8 -1.1
Qualifications: NVQ or HND or HNC or equivalent 0.2 0.2 0.9 0.3 0.4 0.6 -0.1 -0.9 0.2
Commuting to job workplace: Car/motor vehicle 1.0 1.2 3.0 -0.7 -1.7 -0.9 -0.6 -0.1 -1.5
Illness, injury, bereavement, stress in last 2 years 0.8 1.0 2.8 -1.0 -1.7 -1.1 0.3 -0.6 0.6
Medication: Aspirin 1.1 1.5 3.8 -1.9 -1.3 -1.7 -0.5 0.3 0.3
Supplements: Vitamin C 0.5 0.6 1.7 -0.3 -0.9 0.8 -0.5 0.6 -1.3
Knee pain experienced in last month 0.8 1.3 2.7 -1.2 1.6 -1.3 -1.0 -0.6 -0.6
Hypertension (Self-reported) 0.3 0.9 2.4 -0.7 -0.1 -1.1 0.9 1.5 0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.5 0.6 1.6 -0.4 0.7 1.2 0.3 0.3 -1.0
Illnesses of father: Heart disease 0.1 0.2 0.9 -0.0 -0.4 -0.2 0.9 -0.1 -0.4
Illnesses of siblings: Diabetes 0.8 1.0 3.4 -0.5 1.2 -1.8 -0.5 0.2 0.9
Smoking status: Previous 0.6 0.8 3.2 0.2 0.2 -0.1 -0.5 -1.8 -1.2
Forced expiratory volume in 1-second (FEV1), predicted 1.8 3.8 12.9 1.5 -2.6 -3.6 -0.6 0.2 0.5
Whole body fat-free mass 0.9 5.0 26.4 -1.4 -0.3 -5.1 -0.7 0.4 -0.7
Leg fat-free mass (right) 0.6 3.4 17.2 -1.3 -0.4 -4.2 -0.9 0.4 -0.4
Arm fat percentage (left) 0.5 1.9 5.4 -1.6 2.3 0.5 0.5 -1.1 -1.3
Average weekly red wine intake 1.2 1.8 6.4 2.5 -0.8 -0.1 1.5 0.4 -1.1
Handedness (chirality/laterality): Left-handed 1.1 1.3 3.0 -0.6 1.0 -1.3 -1.7 1.1 0.7
Mood swings 0.8 1.4 3.6 -0.4 0.5 1.9 1.9 -1.0 -0.2
Loneliness, isolation 0.6 0.9 1.6 -1.1 0.6 1.0 -0.9 -0.6 1.2
Long-standing illness, disability or infirmity 0.4 0.6 0.8 -0.4 0.9 -0.9 0.9 -0.6 -0.9
Ever had bowel cancer screening 1.1 1.2 4.2 -0.4 -0.8 -0.9 -2.0 1.1 0.5
Diabetes diagnosed by doctor 1.6 2.7 5.8 -2.4 1.1 -1.9 -1.3 -1.8 -0.7
Ever had stillbirth, spontaneous miscarriage or termination 0.5 0.6 1.2 -0.0 -0.3 -1.0 -0.9 1.1 -0.6
Friendships satisfaction 0.7 0.9 3.1 -0.0 -0.0 1.2 -0.9 -0.2 1.8
Qualifications: nursing, teaching 0.7 1.1 1.7 0.8 1.1 -1.3 -1.2 -0.8 -1.0
Commuting to job workplace: Walk 0.9 0.9 2.8 -0.2 1.0 -0.3 -0.8 -1.1 1.7
Eye problems/disorders: Cataract 0.3 0.3 1.0 0.3 1.0 0.4 -0.7 -0.2 0.0
Mouth/teeth dental problems: Mouth ulcers 0.3 0.5 1.9 1.4 0.6 -0.0 0.2 -0.7 0.2
Medication for cholesterol 1.4 2.1 6.7 0.6 -0.5 -0.8 -2.0 0.9 2.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.1 1.3 3.3 1.8 1.3 1.5 0.5 -0.5 0.4
Back pain experienced in last month 1.2 1.7 3.5 1.8 1.5 -0.9 0.7 1.9 -0.5
Mineral and other dietary supplements 0.6 0.7 3.6 -1.9 -0.0 0.0 -0.2 -0.9 -0.1
Breast cancer (self-reported) 2.8 3.4 13.8 3.7 -1.1 1.4 1.7 0.3 -0.6
Asthma (self-reported) 0.1 0.2 0.5 -0.2 0.7 0.4 0.4 0.0 0.7
Osteoporosis (self-reported) 0.6 0.8 1.9 -0.7 0.9 0.9 -1.4 0.9 0.1
Osteoarthritis (self-reported) 1.5 1.9 5.5 0.5 2.2 -0.6 0.4 -0.1 -2.3
Medication: Aspirin 0.7 0.9 2.1 -1.4 -1.2 -1.3 -0.3 0.4 0.5
Medication: Gliclazide 1.0 1.1 2.9 -1.7 0.6 -0.5 -1.5 -0.1 1.0
Illnesses of father: None of the above (group 1) 0.2 0.2 0.9 0.4 -0.1 0.2 0.2 0.1 0.9
Smoking status: Current 0.2 0.4 1.3 0.1 -0.6 -0.1 1.1 -0.8 0.3
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.6 1.4 3.4 1.5 0.9 1.0 0.8 1.8 -0.4
Whole body water mass 0.9 5.1 27.1 -1.5 -0.2 -5.2 -0.8 0.5 -0.7
Leg predicted mass (right) 0.6 3.4 17.4 -1.3 -0.3 -4.2 -0.9 0.4 -0.4
Arm fat mass (left) 0.4 1.8 3.5 -1.9 1.7 -1.4 0.3 -0.4 -1.5
Number of self-reported non-cancer illnesses 0.3 0.5 2.0 -0.3 1.4 -0.9 -0.4 -0.2 0.2
Average weekly champagne plus white wine intake 0.6 0.8 1.5 1.1 -1.2 -1.0 0.2 -0.1 0.9
Miserableness 1.0 1.8 4.5 -0.5 2.1 0.7 0.3 -1.9 -1.4
Guilty feelings 0.7 1.0 3.8 -0.4 1.9 1.2 0.2 -0.2 0.8
Wears glasses or contact lenses 0.9 1.1 3.0 0.1 -1.1 1.7 -0.3 -1.1 -1.0
Ever taken oral contraceptive pill 0.9 0.9 1.9 0.4 -1.4 -0.5 -0.5 -1.3 1.1
Hearing aid user 0.7 0.8 2.7 -1.6 1.1 -0.6 0.0 -0.3 -0.7
Mother’s age at death 0.2 0.3 0.7 -0.5 0.5 0.1 -0.1 -0.5 0.8
Financial situation satisfaction 0.8 1.0 3.4 0.0 0.4 0.7 1.3 1.8 0.3
Tinnitus: Yes, now most or all of the time 0.1 0.1 0.2 0.5 0.1 0.2 0.2 -0.1 0.4
Commuting to job workplace: Public transport 1.5 1.8 3.7 1.5 1.4 0.8 1.4 -0.7 1.9
Eye problems/disorders: Glaucoma 1.1 1.3 2.8 1.1 -0.6 0.6 1.2 -1.4 -1.7
Medication: Blood pressure 0.5 0.9 2.8 -0.8 -0.3 0.2 1.3 -0.4 -1.7
Pain type(s) experienced in last month: Hip pain 0.7 0.9 3.6 0.5 0.5 0.3 1.1 -0.2 -1.9
Supplements: Fish oil (including cod liver oil) 1.6 2.1 8.5 2.9 0.6 0.5 1.6 0.1 1.0
High cholesterol (Self-reported) 0.3 0.6 1.5 0.1 -0.1 0.3 0.9 -1.0 1.2
Medication: Bendroflumethiazide 0.2 0.3 0.8 -0.6 0.7 0.9 -0.3 -0.4 -0.3
Medication: Paracetamol 0.5 0.7 2.1 -0.5 1.5 -0.1 -1.1 0.3 -0.8
Medication: Lisinopril 0.4 0.6 1.1 -1.0 0.8 -1.0 0.6 0.6 -0.1
Medication: Atorvastatin 0.5 0.6 1.7 0.5 0.4 1.1 1.3 -0.4 -0.3
Illnesses of father: High blood pressure 1.0 1.2 3.8 -0.1 -0.6 -0.2 -1.1 1.4 -1.9
Alcohol drinker status: Never 1.1 1.3 4.2 -0.4 1.9 0.1 0.2 2.0 -0.2
Ever smoked 0.5 1.0 3.4 -0.2 -0.7 -1.0 -0.0 -1.8 -0.9
Basal metabolic rate 0.8 4.7 24.7 -1.5 0.1 -5.0 -0.6 0.5 -0.7
Leg fat percentage (left) 0.6 2.3 6.0 -1.3 2.4 0.4 1.5 -0.6 -1.9
Arm fat-free mass (left) 0.8 4.1 20.6 -1.5 0.3 -4.5 -0.3 0.9 -0.9
Number of operations (self-reported) 1.8 2.7 7.9 2.1 1.3 2.8 1.3 0.1 -0.5
Average weekly beer plus cider intake 0.4 0.6 1.6 -0.3 0.3 -1.1 1.3 0.2 -0.5
Irritability 1.2 2.0 4.0 0.7 2.0 1.8 1.8 -0.6 0.7
Risk taking 0.4 0.6 1.3 0.8 0.9 0.2 -0.3 -0.7 -1.1
Ever had prostate specific antigen (PSA) test 0.6 0.7 1.3 1.0 -1.1 -0.7 0.8 0.4 0.8
Fractured/broken bones in last 5 years 0.4 0.6 1.6 -0.1 0.7 0.8 -1.3 0.8 0.3
Age started oral contraceptive pill 1.2 1.5 5.3 -2.3 0.6 -1.0 -1.5 -0.5 0.2
Diastolic blood pressure, automated reading 0.8 2.5 7.6 -2.8 2.1 -0.2 -1.0 -1.2 0.9
Ever depressed for a whole week 1.0 1.2 3.1 -0.4 1.3 1.8 -0.9 0.1 1.2
Unable to work because of sickness or disability 0.5 0.6 1.7 0.1 -1.0 0.1 1.3 -0.3 0.9
Commuting to job workplace: Cycle 0.5 0.6 1.8 1.4 0.4 -0.2 -0.1 -0.3 -1.2
Myopia 0.5 0.7 2.0 -0.7 -0.7 -0.0 -1.4 1.1 -0.4
Vascular/heart problems diagnosed by doctor 0.4 1.1 2.2 1.4 0.3 0.8 -0.8 -1.5 -0.9
Cholesterol lowering medication 0.2 0.3 0.8 -0.9 -0.4 0.0 0.7 -0.1 0.2
Medication: Omeprazole (e.g. Zanprol) 0.7 0.8 2.5 -0.4 -0.2 -0.6 0.4 -1.4 1.6
Pain experienced in last month 1.0 1.7 7.0 -0.9 -2.6 0.6 0.5 -1.0 0.9
Supplements: Calcium 1.2 1.3 2.9 1.7 1.0 0.0 1.3 1.4 -0.6
Basal cell carcinoma (self-reported) 0.4 0.4 0.8 -0.7 0.0 -0.2 -0.9 -0.8 0.7
Heart attack/myocardial infarction (self-reported) 0.3 0.3 0.8 -0.4 0.2 0.5 0.9 -0.7 -0.6
Deep venous thrombosis (DVT) (self-reported) 0.6 0.7 1.5 -0.9 0.5 -0.9 -0.7 1.2 0.6
Heart disease (siblings) 1.3 1.6 4.4 -2.1 -1.3 -1.8 0.2 0.1 -0.3
Alcohol drinker status: Previous 0.8 0.9 2.6 -1.6 0.6 0.9 -0.3 0.4 -1.1
Pack years of smoking 0.4 0.5 2.1 0.2 0.4 1.4 -0.1 -0.7 0.7
Impedance of whole body 0.5 2.7 8.1 2.9 -0.1 1.0 2.3 1.1 0.8
Leg fat mass (left) 0.5 1.8 3.6 -1.8 1.9 -1.3 0.5 -0.1 -1.5
Arm predicted mass (left) 0.8 4.3 21.1 -1.6 0.2 -4.6 -0.2 0.8 -1.2