Best TWAS P=9.55e-13 · Best GWAS P=3.01e-14 conditioned to 0.00214
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | PPA2 | 0.08 | 0.03 | bslmm | 429 | 0.04 | 2.2e-05 | -6.5 | -6.6 | 3.2e-11 | 0.61 | 0.07 | 0.90 | FALSE |
| 2 | GTEx | Brain Cortex | PPA2 | 0.14 | 0.09 | lasso | 9 | 0.09 | 1.6e-03 | -6.7 | -6.9 | 6.1e-12 | 0.79 | 0.05 | 0.63 | FALSE |
| 3 | GTEx | Esophagus Gastroesophageal Junction | PPA2 | 0.29 | 0.15 | lasso | 5 | 0.14 | 8.8e-06 | -7.3 | -7.1 | 9.6e-13 | 0.81 | 0.04 | 0.94 | TRUE |
| 4 | GTEx | Heart Atrial Appendage | PPA2 | 0.15 | 0.05 | lasso | 7 | 0.06 | 7.4e-04 | -6.9 | -6.3 | 3.3e-10 | 0.70 | 0.21 | 0.45 | FALSE |
| 5 | GTEx | Muscle Skeletal | PPA2 | 0.19 | 0.06 | enet | 28 | 0.11 | 8.7e-11 | -7.2 | -5.8 | 7.6e-09 | 0.67 | 0.12 | 0.88 | FALSE |
| 6 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | PPA2 | 0.11 | 0.03 | blup | 84 | 0.03 | 4.7e-04 | -6.4 | -6.1 | 9.5e-10 | 0.49 | 0.08 | 0.86 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | PPA2 | 0.04 | 0.02 | blup | 84 | 0.04 | 6.1e-05 | -7.2 | -6.7 | 2.4e-11 | 0.74 | 0.01 | 0.97 | FALSE |