Best TWAS P=9.7e-08 · Best GWAS P=2.48e-07 conditioned to 0.5
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Adipose Subcutaneous | GGNBP2 | 0.10 | 0.11 | enet | 9 | 0.11 | 3.5e-09 | -4.8 | 5.1 | 2.7e-07 | 0.92 | 0.04 | 0.96 | FALSE |
2 | GTEx | Artery Tibial | GGNBP2 | 0.12 | 0.12 | enet | 15 | 0.12 | 1.2e-09 | 5.0 | 5.1 | 2.7e-07 | 0.95 | 0.02 | 0.98 | FALSE |
3 | GTEx | Brain Hypothalamus | DHRS11 | 0.24 | 0.12 | lasso | 2 | 0.12 | 1.1e-03 | 5.2 | -5.2 | 1.9e-07 | -1.00 | 0.02 | 0.92 | FALSE |
4 | GTEx | Cells EBV-transformed lymphocytes | GGNBP2 | 0.13 | 0.15 | lasso | 2 | 0.13 | 5.5e-05 | 5.1 | 5.2 | 2.5e-07 | 1.00 | 0.02 | 0.95 | FALSE |
5 | GTEx | Cells EBV-transformed lymphocytes | DHRS11 | 0.14 | 0.08 | enet | 3 | 0.07 | 3.2e-03 | 5.1 | -5.1 | 2.7e-07 | -1.00 | 0.02 | 0.90 | FALSE |
6 | GTEx | Esophagus Mucosa | DHRS11 | 0.12 | 0.08 | lasso | 2 | 0.06 | 5.1e-05 | -4.9 | -5.2 | 2.4e-07 | -0.92 | 0.02 | 0.98 | FALSE |
7 | GTEx | Esophagus Muscularis | DHRS11 | 0.14 | 0.08 | lasso | 5 | 0.08 | 8.2e-06 | 5.0 | -5.1 | 2.7e-07 | -0.96 | 0.02 | 0.98 | FALSE |
8 | GTEx | Heart Left Ventricle | MYO19 | 0.10 | 0.06 | lasso | 3 | 0.04 | 5.4e-03 | -4.9 | -5.1 | 2.7e-07 | -0.93 | 0.02 | 0.94 | FALSE |
9 | GTEx | Lung | GGNBP2 | 0.08 | 0.01 | enet | 8 | 0.01 | 3.3e-02 | -4.9 | 5.3 | 9.7e-08 | 0.92 | 0.02 | 0.97 | TRUE |
10 | GTEx | Thyroid | GGNBP2 | 0.07 | 0.06 | lasso | 2 | 0.04 | 2.8e-04 | 5.0 | 5.1 | 2.8e-07 | 0.93 | 0.02 | 0.97 | FALSE |
11 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | ZNHIT3 | 0.05 | 0.03 | enet | 4 | 0.04 | 4.7e-05 | -4.9 | -5.2 | 1.9e-07 | -0.92 | 0.01 | 0.99 | FALSE |
12 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | GGNBP2 | 0.04 | 0.04 | enet | 3 | 0.04 | 6.3e-05 | -4.8 | 5.2 | 1.8e-07 | 0.93 | 0.01 | 0.98 | FALSE |
13 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZNHIT3 | 0.03 | 0.03 | enet | 4 | 0.03 | 1.8e-04 | 5.0 | -5.1 | 3.0e-07 | -0.92 | 0.01 | 0.94 | FALSE |