Best TWAS P=2.8e-14 · Best GWAS P=3.62e-14 conditioned to 1
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adipose Subcutaneous | RIT1 | 0.14 | 0.06 | lasso | 5 | 0.08 | 8.8e-07 | -4.5 | 5.2 | 1.8e-07 | -0.10 | 0.04 | 0.95 | FALSE |
| 2 | GTEx | Artery Aorta | RIT1 | 0.12 | 0.13 | lasso | 7 | 0.08 | 2.9e-05 | -5.0 | 5.2 | 2.0e-07 | -0.04 | 0.02 | 0.98 | FALSE |
| 3 | GTEx | Brain Cerebellar Hemisphere | DCST2 | 0.45 | 0.10 | lasso | 6 | 0.16 | 6.6e-05 | -3.6 | 6.3 | 3.5e-10 | 0.75 | 0.01 | 0.96 | FALSE |
| 4 | GTEx | Colon Transverse | RIT1 | 0.10 | 0.00 | enet | 4 | 0.01 | 9.1e-02 | -5.2 | 5.5 | 4.3e-08 | -0.06 | 0.02 | 0.73 | TRUE |
| 5 | GTEx | Skin Sun Exposed Lower leg | ADAM15 | 0.14 | 0.09 | lasso | 4 | 0.08 | 6.1e-07 | 7.6 | -7.6 | 2.8e-14 | -0.96 | 0.00 | 1.00 | TRUE |
| 6 | NTR | Blood | ZBTB7B | 0.02 | 0.02 | lasso | 1 | 0.01 | 5.4e-05 | 6.3 | 6.3 | 3.1e-10 | 0.67 | 0.78 | 0.12 | FALSE |
| 7 | The Cancer Genome Atlas | Lung Squamous Cell Carcinoma | ZBTB7B | 0.05 | 0.06 | lasso | 2 | 0.05 | 1.8e-06 | 7.6 | -7.6 | 3.1e-14 | -1.00 | 0.00 | 1.00 | FALSE |