Hub : Genes

ZBTB7B

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0600	0.0260	0.00270	0.010	0.020	-0.002	0.022	0.002	1.8e-02	0.00150	7.2e-01	0.00100	1.5e-01
2	NTR	Blood	0.0168	0.0070	0.00160	0.020	0.010	0.007	0.010	0.012	2.7e-07	0.00031	1.5e-03	0.00026	5.4e-05
3	TCGA	Lung Squamous Cell Carcinoma	0.0477	0.0302	0.00460	0.055	0.016	0.046	NA	0.051	6.6e-07	0.00530	4.9e-06	NA	1.8e-06
4	TCGA	Pheochromocytoma and Paraganglioma	0.2910	0.1120	0.00082	0.134	0.055	0.061	NA	0.106	5.6e-06	0.00310	2.0e-03	NA	5.5e-05

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4
Bipolar Disorder (2018)	2.0	3.2	6.2	2.5	-1.7	2.0	0.1
Bipolar Disorder or Schizophrenia	3.0	7.2	10.5	3.2	-2.4	3.2	1.7
Depressed Affect (Nagel 2018)	0.7	1.4	3.0	-0.3	-1.6	0.3	-1.7
Depression (Nagel 2018)	0.1	0.1	0.3	0.3	-0.1	-0.0	-0.6
Intelligence (Savage-Jansen 2018)	0.6	1.8	3.9	0.1	-1.8	-0.6	-2.0
Neuroticism (Nagel 2018)	2.3	5.3	11.5	1.9	-3.4	2.3	-1.1
Schizophrenia (2018)	2.2	4.5	6.2	2.2	-1.6	2.5	2.1
Schizophrenia vs Biploar Disorder	0.6	0.8	2.1	-1.5	-0.9	0.0	-0.4
Worry (Nagel 2018)	1.8	3.8	5.5	2.3	-2.3	2.1	-0.0
Alzheimer’s Disease (in mother)	1.2	1.3	2.3	-1.2	1.2	-0.4	1.5
Alzheimer’s Disease (in father)	0.2	0.2	0.4	0.3	-0.6	-0.6	0.2
Alzheimer’s Disease (including proxy)	0.8	1.1	3.3	-0.7	0.5	-0.6	1.8
Crohns Disease (2017)	1.6	3.5	5.1	-2.3	1.9	-1.9	-1.2
Irritable Bowel Disease (IBD)	2.0	4.7	7.8	-2.8	2.1	-2.6	-0.0
Ulcerative Colitis (UC)	1.1	2.2	4.1	-1.5	1.1	-2.0	1.1
Major Depression (MDD)	1.0	1.3	3.6	-1.2	-0.1	0.3	-1.9
Reaction Time	0.4	0.8	1.7	1.3	-1.1	-0.0	-0.7
Verbal and Numeric Reasoning (VNR)	0.2	0.6	1.2	1.1	-0.8	-0.5	-0.5
Breast Cancer	1.0	2.5	9.0	0.5	0.8	-3.0	-0.0
Ovarian Cancer	0.1	0.2	0.6	-0.1	-0.8	-0.4	-0.1
Prostate Cancer	9.6	13.5	23.5	4.8	-3.7	4.0	-0.8
Age at First Birth	0.4	0.5	1.3	-0.3	1.1	-0.4	0.8
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.9	1.3	2.9	-1.7	0.3	-1.4	-0.0
Coronary Artery Disease (CAD)	0.8	0.9	2.6	1.6	-1.1	0.0	0.0
Crohns Disease (2012)	2.5	4.1	7.9	-2.8	2.4	-1.4	-0.7
Mean Putamen Volume	0.7	0.8	1.6	-0.9	1.3	-0.8	0.5
Fasting Glucose	1.2	1.4	5.3	-2.3	0.0	0.0	0.6
HbA1C	0.9	1.0	1.9	1.3	-0.6	1.4	0.4
HDL Cholesterol	1.6	2.7	4.6	1.5	-2.0	2.2	0.2
LDL Cholesterol	0.2	0.4	1.3	-1.1	0.0	0.2	-0.3
Lupus	0.6	0.8	2.8	-1.7	0.1	-0.3	-0.7
Neuroticism (2016)	0.9	1.3	2.5	1.6	-1.3	0.6	-0.9
Primary Biliary Cirrhosis	0.6	0.9	2.3	-0.9	-0.5	0.6	1.5
Rheumatoid Arthritis	1.3	1.8	3.7	0.5	1.7	-1.9	-0.4
Schizophrenia (2014)	2.1	4.7	6.2	2.1	-2.5	2.2	1.8
Triglycerides	1.3	2.1	3.5	-1.9	1.8	-0.8	1.1
Type 2 Diabetes (T2D) (2012)	0.2	0.3	0.7	0.7	0.8	0.0	0.0
Ulcerative Colitis	1.6	2.3	2.5	-1.6	1.6	-1.5	1.5
Blood Eosinophil Count	2.4	18.4	28.8	4.2	-5.4	5.2	0.3
Blood Platelet Count	1.1	12.2	34.9	0.2	-2.9	5.9	-2.3
Blood Red Count	0.9	8.3	24.5	1.4	-0.6	5.0	-2.5
Blood White Count	0.2	1.8	3.0	-1.2	1.6	0.1	-1.7
Heel T-Score	0.0	0.3	0.8	0.9	0.3	0.6	-0.3
BMI	3.8	22.2	45.2	-3.0	5.2	-6.7	2.8
Height	2.2	43.3	125.4	-1.3	6.4	-11.2	2.3
Waist Hip Ratio (WHR)	8.7	39.3	118.8	1.8	-5.5	10.9	2.1
Systolic Blood Pressure	1.1	5.5	11.7	-0.6	-3.0	3.4	-0.9
Smoking Status	0.9	2.1	3.3	-1.5	1.5	1.0	1.8
Allergy or Eczema	3.6	9.5	32.3	0.8	-2.1	5.7	0.8
Cardiovascular Disease	0.4	1.3	3.9	-2.0	0.1	1.0	-0.3
Hypothyroidism (self reported)	3.5	8.0	13.3	-2.3	3.6	-3.1	1.9
Respiratory disease	2.8	6.3	11.8	0.5	-3.0	3.4	2.0
Type 2 Diabetes (T2D) (2018)	1.3	2.4	5.6	0.1	-2.4	2.0	-0.0
Lung FEV1/FVC ratio	1.2	6.3	18.7	1.9	1.3	4.3	1.0
Lung FVC	0.0	0.1	0.3	-0.5	-0.2	-0.2	0.3
Neuroticism	2.4	5.8	10.8	1.8	-3.3	2.8	-1.0
Chronotype (morning person)	0.1	0.3	0.6	0.5	0.8	-0.7	-0.1
Hair Pigment	0.7	20.2	48.2	-2.3	2.6	-4.5	-6.9
Tanning	2.2	26.4	75.3	-0.1	-5.5	8.7	-0.2
Hand grip strength (left)	2.3	6.1	12.7	-2.9	1.5	-1.1	3.6
Number of treatments/medications taken	0.9	1.6	2.9	-1.7	-0.2	1.3	1.2
Average weekly spirits intake	0.7	0.9	2.8	0.1	-0.7	1.7	0.3
Sensitivity / hurt feelings	5.3	9.1	14.3	3.3	-3.8	3.3	-0.2
Frequency of depressed mood in last 2 weeks	0.5	0.8	2.1	0.9	-0.3	1.4	-0.2
Hearing difficulty/problems: Yes	2.9	4.4	9.0	1.4	-1.9	3.0	1.7
Relative age of first facial hair	1.1	2.2	3.6	-1.6	1.9	-0.3	1.6
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.4	-1.2	0.8	-0.0	-0.3
Ever used hormone-replacement therapy (HRT)	2.0	2.6	5.6	-1.9	0.8	-0.8	2.4
Ever had hysterectomy (womb removed)	1.8	2.0	7.2	-0.4	0.9	-2.7	0.1
Systolic blood pressure, automated reading	0.2	0.5	1.1	-0.7	-1.0	0.6	0.4
Eye problems/disorders: Diabetes related eye disease	1.1	1.2	3.1	1.3	-1.8	0.4	-0.1
Angina	0.3	0.4	0.7	-0.6	0.3	0.8	-0.6
Medication for hormone replacement therapy	0.8	0.9	3.3	-0.4	0.2	-0.2	1.8
Vitamin and mineral supplements	0.5	0.7	1.6	1.3	0.5	-0.5	-0.7
Supplements: Zinc	0.2	0.2	0.8	-0.2	0.0	-0.1	0.9
Medication: Co-codamol	0.4	0.5	1.0	0.6	-0.6	-0.4	1.0
Medication: Metformin	1.4	1.9	4.0	-0.2	-2.0	1.9	0.1
Diabetes (father)	1.3	1.6	1.8	-1.2	1.1	-1.4	1.3
Diabetes (mother)	0.5	0.7	1.6	-1.3	0.9	-0.2	0.5
Severe depression (siblings)	0.8	0.9	2.5	0.7	-0.5	1.6	0.4
Pack years adult smoking proportion	1.1	1.7	4.7	-0.3	2.2	-1.3	0.7
Impedance of leg (right)	13.3	64.2	182.2	3.5	-7.8	13.5	-1.2
Leg fat-free mass (left)	10.8	57.3	158.8	-3.1	7.3	-12.6	2.9
Trunk fat percentage	0.8	3.1	11.2	-0.5	1.0	0.2	3.3
Hand grip strength (right)	1.9	5.2	14.1	-2.0	1.2	-1.2	3.8
Townsend deprivation index at recruitment	0.9	1.2	2.4	-1.4	-0.7	0.5	1.6
Current tobacco smoking	1.5	2.4	5.2	-0.9	2.3	-1.8	0.6
Average weekly fortified wine intake	0.4	0.4	1.6	0.0	0.0	0.4	1.3
Maternal smoking around birth	0.7	1.1	2.7	-1.2	-0.1	-0.3	1.6
Fed-up feelings	0.1	0.2	0.4	-0.3	-0.6	0.5	-0.2
Frequency of unenthusiasm / disinterest in last 2 weeks	0.6	0.8	1.9	-0.5	1.4	-0.9	-0.3
Relative age voice broke	0.1	0.2	0.4	-0.3	0.1	0.5	0.6
Taking other prescription medications	2.2	3.4	9.1	-3.0	1.6	-0.9	1.1
Age when periods started (menarche)	0.3	0.7	2.3	-0.1	-0.3	1.5	0.6
Bilateral oophorectomy (both ovaries removed)	1.3	1.5	2.4	-1.6	1.0	-1.3	0.8
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.6	1.0	-0.4	1.0	-1.0	-0.4
Tinnitus: Yes, but not now, but have in the past	1.5	1.6	3.2	1.0	-1.8	1.5	0.0
Qualifications: CSEs or equivalent	1.5	2.0	4.2	-0.5	1.6	-2.0	0.9
Serious illness, injury or assault to yourself	1.1	1.4	2.2	-1.5	-1.0	0.6	-1.4
High blood pressure	0.2	0.4	1.1	-1.1	-0.1	0.1	-0.8
Hayfever, allergic rhinitis or eczema	3.2	6.8	22.0	-0.2	-2.0	4.7	1.1
Multivitamins +/- minerals	1.1	1.4	2.1	-1.4	1.0	-1.2	1.1
Stomach or abdominal pain in last month	1.5	1.9	5.1	1.4	-0.5	2.3	-0.6
Supplements: Glucosamine	1.9	2.4	6.5	0.8	-2.6	1.5	0.6
Diverticular disease/diverticulitis (self-reported)	0.6	0.7	2.2	1.5	0.8	0.2	0.2
Medication: Atenolol	0.7	0.9	2.0	-1.2	-0.3	1.4	0.2
Medication: Levothyroxine sodium	2.8	4.8	8.0	-2.8	2.6	-1.0	1.9
Sitting height	2.2	15.4	45.3	-0.8	3.9	-6.7	0.7
Chronic bronchitis/emphysema (father)	0.2	0.2	0.5	-0.1	0.3	-0.7	0.5
High blood pressure (mother)	0.7	1.0	1.8	1.3	-0.9	-0.4	-1.1
Body mass index (BMI)	4.0	16.9	35.0	-2.3	4.0	-5.9	3.4
Impedance of leg (left)	12.7	61.8	176.9	3.5	-7.5	13.3	-1.6
Leg predicted mass (left)	10.8	57.5	158.8	-3.1	7.3	-12.6	2.9
Trunk fat mass	2.0	8.6	14.3	-1.5	2.7	-3.2	3.8
Waist circumference	2.9	10.5	15.6	-2.2	2.9	-3.7	4.0
Number of incorrect matches in round	1.2	2.0	3.5	1.3	1.9	-1.0	1.4
Past tobacco smoking	1.1	2.0	3.8	2.0	-0.9	-0.9	-1.6
Alcohol usually taken with meals	1.2	2.0	6.3	-0.1	-1.0	2.5	-0.8
Nervous feelings	1.7	3.1	6.2	1.4	-2.5	2.0	-0.4
Frequency of tenseness / restlessness in last 2 weeks	0.3	0.5	1.1	0.6	0.1	1.0	0.7
Hearing difficulty/problems with background noise	2.2	3.5	5.8	1.1	-2.1	2.4	1.6
Hair/balding pattern: Pattern 2	0.4	0.5	1.2	-1.1	0.6	-0.3	-0.5
Had menopause	0.7	0.8	2.4	-1.6	-0.1	-0.9	-0.2
Had other major operations	2.5	3.0	5.2	-2.0	2.3	-1.7	0.1
Forced vital capacity (FVC)	0.3	1.0	3.1	0.8	0.3	-1.8	0.3
Heel bone mineral density (BMD) T-score, automated (right)	0.3	0.7	1.3	-0.5	0.9	-1.1	-0.6
Ever unenthusiastic/disinterested for a whole week	0.2	0.3	0.6	-0.4	-0.6	0.8	-0.1
Qualifications: None of the above	1.9	4.1	8.6	-1.8	2.0	-0.8	2.9
Financial difficulties in last 2 years	0.7	0.9	1.9	1.4	-0.9	0.3	0.8
Mouth/teeth dental problems	0.8	1.3	2.2	1.0	-0.6	-1.5	1.3
Heart attack	0.3	0.4	1.0	-0.7	0.1	-0.4	-1.0
Allergy	2.6	6.0	15.7	-0.1	2.2	-4.0	-1.8
Pain all over the body in last month	0.1	0.1	0.2	-0.4	0.1	-0.3	0.4
Diabetes (self-reported)	1.4	2.1	6.4	-0.3	-1.4	2.5	-0.1
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	2.5	-0.3	-0.9	1.6	0.5
Medication: Ramipril	0.3	0.4	1.5	-1.2	-0.0	0.4	-0.3
Medication: Simvastatin	0.4	0.5	0.9	-1.0	-0.6	0.8	-0.4
Fluid intelligence score	0.4	0.8	1.5	1.1	-1.2	-0.5	0.1
Illnesses of siblings	0.4	0.6	1.3	0.9	-0.0	0.6	-1.1
Neuroticism score	2.0	4.2	5.8	2.3	-2.4	2.4	-0.3
Weight	6.7	33.2	78.3	-2.8	5.4	-8.8	4.1
Impedance of arm (right)	8.6	40.3	102.0	4.8	-6.0	10.1	-1.0
Arm fat percentage (right)	0.9	3.7	11.7	0.3	1.2	-1.2	3.4
Trunk fat-free mass	9.2	52.8	151.3	-2.9	6.6	-12.3	2.9
Hip circumference	7.3	31.4	85.0	-2.7	5.2	-9.2	2.6
Time employed in main current job	0.9	1.0	2.4	0.9	-0.4	0.8	-1.6
Alcohol intake versus 10 years previously	0.8	1.2	2.8	-0.5	1.1	-1.7	0.6
Father’s age at death	0.8	1.1	1.4	1.0	-1.2	0.9	1.1
Worrier / anxious feelings	2.7	5.1	11.8	3.4	-1.8	2.1	-0.9
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.6	1.2	-1.1	0.4	-0.4	0.8
Falls in the last year	0.2	0.3	1.2	-1.1	-0.0	-0.1	0.3
Hair/balding pattern: Pattern 3	1.1	1.7	2.4	1.3	-1.6	1.3	-0.9
Number of live births	0.2	0.3	0.8	-0.9	-0.2	0.6	-0.2
Forced expiratory volume in 1-second (FEV1)	0.1	0.5	1.8	1.3	0.2	-0.1	0.3
Pulse rate	0.7	1.2	3.1	0.5	-0.9	0.8	1.7
Happiness	2.8	3.3	4.5	1.2	-1.8	2.1	-2.0
Noisy workplace	0.7	0.9	1.8	-0.7	1.3	-0.5	1.0
Qualifications: A levels/AS levels or equivalent	3.0	6.6	13.5	2.4	-3.7	2.7	-0.4
Serious illness, injury or assault of a close relative in last 2 years	0.5	0.6	1.4	0.3	1.0	-0.1	-1.2
Mouth/teeth dental problems: Dentures	1.6	2.7	6.9	-1.2	0.3	1.5	-2.6
Asthma	2.3	4.5	9.8	0.8	-3.1	2.6	0.7
Medication: Ibuprofen (e.g. Nurofen)	1.0	1.3	4.6	2.1	-0.3	-0.0	0.7
Medication: Cholesterol lowering	0.7	1.0	2.8	-1.7	0.9	0.5	-0.5
Depression (self-reported)	0.4	0.4	0.9	-1.0	-0.2	0.9	-0.2
Medication: Lansoprazole	3.5	4.0	10.0	-3.2	2.1	-1.1	-0.5
Prospective memory result	0.9	1.1	2.3	-0.5	1.1	-0.8	1.5
Lung cancer (father)	0.8	1.0	2.1	-1.4	1.1	-0.5	-0.7
Illnesses of mother	0.3	0.4	0.8	0.3	-0.9	0.7	0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.2	0.7	1.3	1.1	0.6	-1.0	-0.2
Pulse wave Arterial Stiffness index	0.3	0.4	0.7	-0.6	-0.4	0.5	-0.8
Impedance of arm (left)	7.1	32.7	87.4	4.2	-5.0	9.3	-0.8
Arm fat mass (right)	3.5	14.3	26.3	-1.3	3.6	-5.1	4.1
Trunk predicted mass	9.1	51.9	148.8	-2.9	6.6	-12.2	2.8
Standing height	1.5	15.3	44.0	-1.1	3.5	-6.6	1.9
Length of working week for main job	0.9	1.0	1.5	-0.2	1.0	-1.2	-1.2
Exposure to tobacco smoke at home	0.2	0.3	0.8	-0.4	-0.2	-0.2	0.9
Breastfed as a baby	0.6	0.7	2.8	-1.7	0.1	0.3	0.1
Tense / ‘highly strung’	1.1	1.9	5.5	0.5	-1.2	2.3	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.1	0.1	0.3	0.5	-0.3	-0.0	-0.1
Hair/balding pattern: Pattern 4	0.3	0.6	1.3	0.9	0.1	-0.5	1.2
Birth weight of first child	4.7	8.5	16.5	-1.8	3.8	-4.1	0.2
Peak expiratory flow (PEF)	1.9	4.5	8.0	2.4	-2.0	2.8	0.1
Pulse wave reflection index	1.5	1.9	6.9	-0.5	-0.2	-0.6	-2.6
Ever highly irritable/argumentative for 2 days	0.9	1.1	3.5	0.5	0.8	-0.3	1.9
Loud music exposure frequency	1.0	1.1	1.6	1.3	-0.9	1.2	0.8
Qualifications: O levels/GCSEs or equivalent	2.7	4.3	11.3	3.4	-2.0	1.0	-0.9
Mouth/teeth dental problems: Bleeding gums	2.2	2.9	6.6	-1.3	2.6	-1.7	-0.2
Blood clot in the leg (DVT)	1.4	1.8	3.5	1.6	-0.1	-1.9	-1.1
Medication: Paracetamol	0.2	0.4	1.5	0.0	0.2	-0.1	1.2
Headache pain in last month	0.6	1.1	3.8	1.9	-0.2	0.7	-0.4
Medication for cholesterol, blood pressure or diabetes	1.1	1.8	5.1	2.2	-1.2	0.1	0.7
Glaucoma (self-reported)	0.6	0.7	1.4	-0.8	-0.3	0.9	-1.2
Gout (self-reported)	7.5	10.3	15.4	-2.9	3.4	-3.9	2.4
Hypothyroidism/myxoedema (self-reported)	3.5	6.9	10.4	-3.1	3.2	-2.2	1.6
Medication: Amlodipine	0.9	1.3	4.0	-0.6	-0.1	1.0	-2.0
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.6	-0.3	-0.7	-0.1	0.7
Birth weight	11.7	25.3	57.6	-1.4	6.3	-7.6	1.6
Chronic bronchitis/emphysema (mother)	0.4	0.4	0.9	-0.4	1.0	-0.8	0.2
High blood pressure (siblings)	0.2	0.4	1.2	1.1	-0.2	0.2	0.4
Forced vital capacity (FVC), Best measure	0.2	0.9	3.0	0.5	0.6	-1.7	0.1
Body fat percentage	0.8	3.2	11.4	-0.8	0.7	0.4	3.4
Leg fat percentage (right)	1.2	4.3	13.4	-1.7	0.5	0.7	3.7
Arm fat-free mass (right)	9.9	50.9	136.9	-3.9	6.7	-11.7	2.4
Exposure to tobacco smoke outside home	1.1	1.4	4.3	2.1	-0.7	0.8	0.4
Comparative body size at age 10	0.6	1.7	4.8	0.7	0.5	-2.2	-1.0
Number of full brothers	1.7	2.1	3.4	-1.8	1.6	-1.4	0.9
Worry too long after embarrassment	4.2	7.1	10.1	3.2	-3.1	2.7	-1.2
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	5.1	0.2	0.1	-0.1	-2.2
Wheeze or whistling in the chest in last year	0.5	0.9	3.4	0.1	-0.5	-0.3	1.8
Number of children fathered	0.8	0.8	1.5	-1.2	0.6	-0.4	1.1
Reason for reducing amount of alcohol drunk: Health precaution	0.4	0.5	1.7	0.3	-0.1	-0.2	1.3
Age at first live birth	1.4	2.5	4.8	0.1	-1.6	2.2	-1.6
Pulse wave peak to peak time	0.5	0.6	0.7	0.7	0.5	-0.8	0.9
Health satisfaction	0.6	0.8	2.4	-1.5	0.2	0.5	0.9
Shortness of breath walking on level ground	2.7	3.2	6.6	-2.3	0.9	-0.3	2.6
Qualifications: College or University degree	3.0	9.3	16.1	3.5	-4.0	2.4	-1.8
Eye problems/disorders: None of the above	2.3	2.6	7.5	1.4	-0.8	-0.6	2.7
Mouth/teeth dental problems: Loose teeth	0.2	0.3	0.8	0.5	0.2	-0.3	-0.9
Emphysema/chronic bronchitis	0.1	0.1	0.3	-0.1	0.1	0.5	0.3
Medication for pain relief, constipation, heartburn	0.7	1.2	2.7	-0.0	0.3	-1.4	-1.6
Neck or shoulder pain in last month	0.2	0.3	0.9	-0.4	-0.9	0.2	0.3
Medication: Blood pressure	0.5	0.9	3.2	-1.8	0.2	0.6	-0.3
Angina (self-reported)	0.3	0.4	0.6	-0.6	0.2	0.8	-0.7
Migraine (self-reported)	1.5	1.9	4.1	2.0	-1.4	1.2	-0.1
Medication: Ibuprofen	1.0	1.1	1.7	1.3	-0.8	1.1	1.1
Medication: Allopurinol	10.1	13.4	18.0	-3.6	4.1	-4.2	2.4
Medication: Omeprazole	0.8	1.0	2.6	-1.6	0.5	0.7	0.9
Medication: Seretide 50 evohaler	1.1	1.3	4.4	-0.7	0.6	-2.1	-0.2
Mean time to correctly identify matches	0.5	0.9	2.1	1.4	-0.6	0.2	-1.0
Heart disease (mother)	0.7	0.8	1.6	0.1	1.2	-0.7	-1.3
Reproduciblity of spirometry measurement using ERS/ATS criteria	2.3	2.8	6.4	-2.5	1.3	-1.6	-0.6
Whole body fat mass	2.6	11.0	15.5	-1.8	3.2	-3.8	3.9
Leg fat mass (right)	2.7	10.6	15.1	-2.4	3.1	-3.9	3.5
Arm predicted mass (right)	10.3	52.7	139.2	-4.2	6.8	-11.8	2.6
Pulse rate, automated reading	0.8	2.7	4.7	2.2	-1.6	1.8	0.8
Alcohol intake frequency.	1.0	2.3	3.3	1.0	1.4	-1.7	-1.8
Comparative height size at age 10	2.7	14.8	37.5	-2.6	3.5	-6.1	1.7
Number of full sisters	2.9	3.6	4.7	-1.9	2.0	-1.4	2.2
Suffer from ‘nerves’	1.0	1.5	2.6	1.6	-1.4	1.2	0.1
Overall health rating	0.7	1.5	5.2	-0.6	0.6	-0.0	2.3
Chest pain or discomfort	0.8	1.2	2.7	-1.6	0.9	-0.5	0.9
Had major operations	1.0	1.2	1.7	0.2	-1.2	1.2	-1.3
Age at last live birth	2.0	2.8	7.5	0.9	-1.7	2.7	-0.3
Family relationship satisfaction	1.5	1.8	4.0	-0.5	-1.6	0.7	-2.0
Leg pain on walking	1.4	1.7	2.6	-1.5	0.5	-1.6	1.2
Qualifications: NVQ or HND or HNC or equivalent	4.2	5.0	7.7	-2.1	2.8	-2.8	0.3
Commuting to job workplace: Car/motor vehicle	0.7	0.8	1.7	-1.1	0.2	1.3	-0.3
Illness, injury, bereavement, stress in last 2 years	0.1	0.2	0.3	-0.6	0.3	0.3	0.4
Medication: Aspirin	0.9	1.2	3.4	-1.1	-0.3	1.8	-0.6
Supplements: Vitamin C	2.3	2.7	6.4	0.6	-2.5	2.0	-0.3
Knee pain experienced in last month	1.8	2.8	4.2	-1.0	2.0	-2.1	1.4
Hypertension (Self-reported)	0.3	0.7	2.0	-1.4	-0.1	0.3	-0.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.9	2.3	5.6	-2.4	1.4	-0.1	1.3
Illnesses of father: Heart disease	0.5	0.6	1.4	-0.2	0.3	-1.0	1.2
Illnesses of siblings: Diabetes	0.8	1.0	2.5	-0.2	-1.0	-1.6	0.8
Smoking status: Previous	0.8	1.2	3.7	-1.9	0.6	0.6	0.4
Forced expiratory volume in 1-second (FEV1), predicted	1.8	3.7	12.5	0.2	1.4	-3.5	0.6
Whole body fat-free mass	10.3	59.0	166.4	-3.2	7.2	-12.9	2.8
Leg fat-free mass (right)	11.4	60.7	169.0	-3.1	7.5	-13.0	2.6
Arm fat percentage (left)	1.1	4.5	12.1	-0.3	1.8	-1.6	3.5
Average weekly red wine intake	0.4	0.7	1.8	-0.6	-0.2	1.3	-0.7
Handedness (chirality/laterality): Left-handed	0.2	0.2	0.4	-0.6	0.6	0.0	0.4
Mood swings	1.1	2.0	3.4	1.9	-1.4	0.8	-1.4
Loneliness, isolation	1.3	1.8	6.2	-0.3	0.3	-0.8	-2.5
Long-standing illness, disability or infirmity	1.2	1.9	5.7	-2.4	1.2	0.2	0.4
Ever had bowel cancer screening	1.7	2.0	3.7	-1.0	1.8	-1.9	0.3
Diabetes diagnosed by doctor	1.0	1.6	3.9	-0.7	-1.4	2.0	0.2
Ever had stillbirth, spontaneous miscarriage or termination	0.8	0.9	2.1	-0.3	-0.5	1.5	-1.0
Friendships satisfaction	2.6	3.2	7.0	0.7	-2.7	2.1	-0.9
Qualifications: nursing, teaching	2.0	3.1	7.1	0.8	-2.7	1.6	-1.4
Commuting to job workplace: Walk	0.6	0.6	1.8	-0.4	-0.3	0.6	1.4
Eye problems/disorders: Cataract	2.1	2.5	7.0	-2.6	1.5	-0.3	-0.7
Mouth/teeth dental problems: Mouth ulcers	0.4	0.6	1.9	-0.0	-0.4	0.5	1.4
Medication for cholesterol	1.2	1.9	3.7	0.5	1.9	-1.9	0.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.3	1.5	2.6	1.4	-1.6	0.9	0.8
Back pain experienced in last month	0.5	0.8	1.4	-0.0	1.2	-1.1	0.8
Mineral and other dietary supplements	1.3	1.7	4.7	0.6	2.2	-0.5	-1.2
Breast cancer (self-reported)	0.3	0.4	0.8	-0.3	-0.9	0.5	-0.6
Asthma (self-reported)	2.0	4.0	8.2	0.8	-2.9	2.6	0.8
Osteoporosis (self-reported)	0.3	0.3	0.8	-0.9	-0.4	0.0	-0.6
Osteoarthritis (self-reported)	2.4	3.1	4.1	-2.0	1.9	-1.7	1.5
Medication: Aspirin	1.1	1.4	3.3	-1.2	-0.3	1.8	-1.0
Medication: Gliclazide	0.7	0.8	1.5	-0.6	-1.2	1.1	0.4
Illnesses of father: None of the above (group 1)	0.4	0.5	1.2	-0.4	-0.4	1.1	-0.7
Smoking status: Current	1.1	1.8	4.3	-0.3	2.1	-1.3	1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.2	0.5	1.1	-0.1	0.2	1.1	-0.8
Whole body water mass	10.6	60.3	169.0	-3.3	7.3	-13.0	2.9
Leg predicted mass (right)	11.5	61.5	171.6	-3.2	7.6	-13.1	2.6
Arm fat mass (left)	3.8	15.7	28.4	-1.5	3.9	-5.3	4.1
Number of self-reported non-cancer illnesses	0.7	1.2	2.8	-1.7	0.5	1.0	0.9
Average weekly champagne plus white wine intake	1.0	1.4	2.9	0.6	-0.8	1.3	1.7
Miserableness	0.4	0.7	1.3	-0.1	-1.1	0.9	-0.8
Guilty feelings	1.4	2.2	4.6	1.9	-0.7	-0.3	2.1
Wears glasses or contact lenses	2.9	3.4	8.9	-0.2	-2.0	3.0	-0.7
Ever taken oral contraceptive pill	1.6	1.7	2.8	1.3	-1.1	1.7	1.2
Hearing aid user	0.4	0.5	1.8	-0.0	0.1	0.4	1.4
Mother’s age at death	1.5	1.9	5.0	0.8	-1.4	2.2	0.2
Financial situation satisfaction	0.6	0.7	2.3	-1.5	0.2	0.0	-0.6
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.0	0.4	-0.9	1.4	0.8
Commuting to job workplace: Public transport	0.9	1.1	3.1	1.8	-0.5	-0.9	0.4
Eye problems/disorders: Glaucoma	1.2	1.4	4.1	-0.3	-0.7	1.0	-2.0
Medication: Blood pressure	0.2	0.4	0.8	-0.7	-0.9	-0.2	-0.6
Pain type(s) experienced in last month: Hip pain	3.7	4.7	8.1	-2.4	2.9	-2.1	0.8
Supplements: Fish oil (including cod liver oil)	0.6	0.8	2.4	-0.7	-1.6	0.3	0.5
High cholesterol (Self-reported)	0.1	0.2	0.3	0.0	-0.2	0.6	-0.6
Medication: Bendroflumethiazide	0.6	0.9	2.8	0.1	-1.7	0.4	-0.7
Medication: Paracetamol	0.4	0.6	0.9	-0.8	-0.2	0.9	0.9
Medication: Lisinopril	0.4	0.5	1.6	-0.1	-0.5	0.4	-1.3
Medication: Atorvastatin	0.8	0.9	3.6	-0.3	0.1	0.0	-1.9
Illnesses of father: High blood pressure	1.2	1.5	5.3	2.3	-0.7	-0.3	-0.4
Alcohol drinker status: Never	0.1	0.1	0.3	-0.2	-0.4	0.3	-0.5
Ever smoked	1.5	2.7	5.7	-1.9	0.6	1.2	2.4
Basal metabolic rate	10.0	55.1	151.3	-3.1	7.0	-12.3	3.3
Leg fat percentage (left)	1.0	3.8	11.0	-1.8	0.8	0.2	3.3
Arm fat-free mass (left)	9.6	48.5	132.2	-3.0	6.5	-11.5	3.1
Number of operations (self-reported)	0.7	1.1	2.5	-1.6	0.4	-1.1	-0.5
Average weekly beer plus cider intake	1.9	2.8	6.7	-0.1	1.0	-1.8	2.6
Irritability	1.1	1.9	4.1	0.6	-1.3	2.0	-1.3
Risk taking	0.5	0.7	1.7	-0.2	0.3	1.3	1.1
Ever had prostate specific antigen (PSA) test	2.3	2.6	4.2	0.0	-1.5	2.0	2.0
Fractured/broken bones in last 5 years	0.1	0.1	0.2	0.3	-0.5	-0.0	-0.4
Age started oral contraceptive pill	0.6	0.7	1.9	-0.9	-0.4	-0.0	-1.4
Diastolic blood pressure, automated reading	0.8	2.6	5.7	1.7	-2.4	0.8	1.1
Ever depressed for a whole week	2.5	3.1	7.4	1.1	-1.9	2.7	-0.3
Unable to work because of sickness or disability	1.0	1.3	2.8	-1.5	-0.0	-0.4	1.7
Commuting to job workplace: Cycle	0.7	0.9	2.6	-0.0	-0.7	0.7	-1.6
Myopia	0.5	0.7	1.8	-0.0	-0.6	0.7	1.3
Vascular/heart problems diagnosed by doctor	0.4	1.0	2.6	1.6	-0.1	0.2	1.1
Cholesterol lowering medication	1.0	1.4	2.5	0.0	-1.5	1.6	-0.9
Medication: Omeprazole (e.g. Zanprol)	2.4	2.9	6.8	-2.6	1.6	0.3	1.4
Pain experienced in last month	0.7	1.1	2.3	-1.5	-0.5	0.6	-1.2
Supplements: Calcium	1.0	1.1	1.9	-1.0	-1.4	0.7	-0.9
Basal cell carcinoma (self-reported)	0.2	0.2	0.5	-0.2	0.4	-0.7	-0.4
Heart attack/myocardial infarction (self-reported)	0.3	0.4	0.8	-0.9	0.2	-0.5	-0.7
Deep venous thrombosis (DVT) (self-reported)	1.1	1.4	2.5	1.6	-0.2	-1.5	-1.0
Heart disease (siblings)	1.2	1.5	2.8	-0.4	1.5	-1.0	1.7
Alcohol drinker status: Previous	3.0	3.4	5.7	-2.4	2.1	-1.8	-0.5
Pack years of smoking	1.3	1.9	4.7	-0.6	2.2	-1.3	0.9
Impedance of whole body	11.2	56.8	158.8	4.2	-7.1	12.6	-1.1
Leg fat mass (left)	3.0	11.6	17.9	-2.4	3.4	-4.2	3.4
Arm predicted mass (left)	9.7	49.3	134.6	-3.2	6.5	-11.6	3.1