TWAS hub - ADAM15

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.5000	0.0570	2.8e-15	0.143	0.120	0.254	0.211	0.253	4.9e-17	2.4e-14	9.1e-31	3.4e-25	1.3e-30
2	GTEx	Brain Cortex	0.4260	0.1260	8.4e-04	0.031	NA	0.102	NA	0.112	4.9e-02	NA	9.4e-04	NA	5.3e-04
3	GTEx	Cells EBV-transformed lymphocytes	0.1820	0.0760	2.0e-03	-0.003	NA	-0.008	NA	-0.008	4.1e-01	NA	8.0e-01	NA	7.4e-01
4	GTEx	Cells Transformed fibroblasts	0.1440	0.0530	5.5e-05	0.014	NA	0.014	NA	0.021	2.8e-02	NA	2.8e-02	NA	9.3e-03
5	GTEx	Esophagus Mucosa	0.1110	0.0440	4.8e-04	0.024	NA	0.037	NA	0.035	9.5e-03	NA	1.5e-03	NA	2.1e-03
6	GTEx	Skin Sun Exposed Lower leg	0.1390	0.0480	7.7e-04	0.093	NA	0.067	NA	0.077	4.0e-08	NA	3.1e-06	NA	6.1e-07
7	GTEx	Whole Blood	0.1020	0.0410	1.5e-04	0.002	NA	0.001	NA	0.003	2.1e-01	NA	2.4e-01	NA	1.5e-01
8	METSIM	Adipose	0.0736	0.0308	3.5e-04	0.026	0.021	0.036	0.035	0.021	6.6e-05	3.2e-04	3.9e-06	4.4e-06	3.1e-04
9	YFS	Blood	0.5831	0.0373	0.0e+00	0.147	0.326	0.402	0.404	0.400	7.6e-46	3.5e-110	4.8e-143	3.7e-144	2.9e-142
10	TCGA	Colon Adenocarcinoma	0.1500	0.0580	2.7e-04	0.018	0.084	0.059	NA	0.046	3.2e-02	1.4e-05	2.6e-04	NA	1.1e-03
11	TCGA	Kidney Renal Clear Cell Carcinoma	0.1766	0.0587	4.3e-06	0.038	0.060	0.051	NA	0.028	3.5e-05	2.4e-07	2.1e-06	NA	3.8e-04
12	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0850	0.0490	9.2e-03	-0.005	0.017	-0.003	NA	-0.005	1.0e+00	3.6e-02	5.5e-01	NA	8.5e-01
13	TCGA	Brain Lower Grade Glioma	0.0721	0.0374	5.2e-04	-0.002	0.014	0.035	NA	0.001	6.3e-01	9.5e-03	6.1e-05	NA	2.6e-01

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10	11	12	13
Irritable Bowel Disease (IBD)	9.2	21.8	43.3	-4.5	-0.6	-5.1	-6.5	-3.6	-2.7	-4.3	-3.5	-6.6	-4.1	-5.0	-4.9	-5.7
Crohns Disease (2012)	9.2	14.9	34.9	-3.2	-0.5	-4.9	-5.9	-3.2	-1.4	-3.9	-2.6	-5.4	-3.2	-4.2	-3.6	-4.5
Crohns Disease (2017)	7.6	16.7	44.6	-3.8	-0.4	-5.3	-6.7	-2.7	-1.8	-3.7	-2.2	-6.3	-2.6	-4.5	-3.5	-4.7
Impedance of arm (right)	6.3	29.3	99.8	-0.6	4.6	2.8	2.8	5.0	10.0	5.9	1.1	2.5	7.8	4.3	8.2	5.4
Past tobacco smoking	5.6	10.3	21.6	4.0	0.5	1.3	2.3	0.2	-0.6	2.0	4.3	4.7	3.3	4.5	3.8	4.6
Ulcerative Colitis (UC)	5.5	10.3	17.6	-3.2	-0.3	-2.5	-3.5	-2.9	-2.3	-2.7	-3.2	-3.8	-3.8	-3.5	-4.2	-4.0
Prostate Cancer	5.4	7.7	21.2	0.5	2.7	0.3	0.4	3.3	4.6	3.3	0.6	1.6	4.1	0.8	4.3	3.2
Impedance of arm (left)	5.3	24.6	85.6	-0.6	3.9	2.3	2.4	4.5	9.2	4.9	0.7	2.6	7.2	4.5	7.5	5.2
Arm predicted mass (right)	5.2	26.7	151.3	2.0	-3.8	-1.3	-0.5	-6.2	-12.3	-5.3	-0.5	0.1	-7.0	0.4	-6.8	-3.6
Mouth/teeth dental problems	5.1	7.8	18.7	1.8	0.6	1.2	2.7	-0.1	-1.7	3.4	3.9	3.5	2.7	4.3	3.4	3.0
Ever smoked	5.1	8.9	23.1	-4.0	-0.5	-1.3	-1.6	-0.9	0.7	-1.6	-3.2	-4.2	-3.5	-4.2	-3.2	-4.8
Arm fat-free mass (right)	5.0	25.5	146.4	2.2	-3.8	-1.3	-0.5	-6.1	-12.1	-5.1	-0.6	0.1	-6.7	0.2	-6.6	-3.5
Impedance of whole body	5.0	25.3	153.8	-2.1	4.0	0.7	0.2	5.2	12.4	5.1	-1.1	0.8	6.3	1.2	6.6	3.8
Impedance of leg (right)	4.9	23.5	179.6	-3.7	3.3	-1.3	-2.4	4.5	13.4	4.2	-2.8	-2.0	4.1	-3.2	4.0	1.3
Smoking status: Previous	4.9	7.3	15.1	-2.6	-0.9	-1.4	-2.4	0.2	0.5	-2.0	-3.7	-3.9	-2.8	-3.7	-3.5	-3.6
Arm predicted mass (left)	4.9	25.1	148.8	1.8	-3.0	-0.7	0.1	-6.3	-12.2	-4.7	-0.3	-0.0	-6.9	0.3	-6.6	-3.6
High blood pressure (mother)	4.8	6.7	12.2	2.3	0.4	2.7	2.6	1.0	0.1	1.6	2.9	3.4	3.3	3.1	3.4	3.5
Impedance of leg (left)	4.8	23.3	176.9	-3.5	3.1	-1.5	-2.7	4.7	13.3	4.0	-2.7	-1.7	4.3	-2.7	4.3	1.7
Nervous feelings	4.8	8.9	13.7	1.7	2.7	2.6	3.5	2.9	1.8	2.6	2.1	3.6	3.5	3.3	3.7	3.7
Birth weight	4.8	10.4	57.9	0.5	-1.8	2.2	1.6	-2.5	-7.6	-3.8	-2.9	-0.2	-3.5	1.4	-4.5	-1.7
Arm fat-free mass (left)	4.8	24.5	144.0	1.8	-3.2	-0.5	0.2	-6.2	-12.0	-4.6	-0.2	0.2	-6.9	0.4	-6.5	-3.5
Whole body water mass	4.7	26.8	185.0	2.5	-3.4	0.2	1.3	-6.2	-13.6	-4.5	0.8	1.2	-6.2	2.1	-5.7	-2.8
Whole body fat-free mass	4.6	26.1	182.2	2.5	-3.3	0.2	1.3	-6.1	-13.5	-4.4	0.8	1.3	-6.1	2.1	-5.6	-2.7
Leg fat-free mass (right)	4.6	24.4	179.6	3.3	-2.5	1.0	2.2	-5.7	-13.4	-4.0	1.6	2.3	-4.6	3.9	-4.3	-1.4
Leg predicted mass (right)	4.5	24.3	179.6	3.4	-2.6	1.1	2.2	-5.6	-13.4	-4.1	1.5	2.3	-4.5	4.0	-4.2	-1.4
Leg fat-free mass (left)	4.4	23.3	171.6	3.1	-2.5	1.0	2.1	-5.7	-13.1	-3.9	1.3	2.0	-4.7	3.6	-4.4	-1.7
Leg predicted mass (left)	4.4	23.2	171.6	3.1	-2.5	1.0	2.2	-5.6	-13.1	-3.8	1.3	1.9	-4.6	3.6	-4.4	-1.7
Trunk fat-free mass	4.4	25.1	166.4	1.9	-3.5	-0.1	0.9	-6.0	-12.9	-4.3	0.5	0.9	-6.5	1.1	-5.8	-3.2
Trunk predicted mass	4.4	25.1	166.4	1.9	-3.4	-0.1	0.9	-6.0	-12.9	-4.3	0.5	0.8	-6.5	1.0	-5.9	-3.2
Migraine (self-reported)	4.3	5.3	11.3	0.0	2.8	1.7	2.1	3.2	1.2	3.4	2.0	1.1	3.2	1.7	2.9	1.9
Basal metabolic rate	4.3	23.9	166.4	2.4	-2.9	0.2	1.4	-6.1	-12.9	-4.2	0.7	1.3	-5.7	2.4	-5.2	-2.5
Medication: Allopurinol	4.1	5.4	23.0	0.7	-2.9	-1.2	0.4	-3.8	-4.8	-2.3	-0.7	-0.2	-2.3	0.7	-2.4	-2.2
Pain type(s) experienced in last month: Hip pain	4.1	5.2	12.5	-0.6	-1.5	-1.5	-0.8	-2.3	-2.4	-2.5	-0.9	-2.8	-3.3	-1.9	-3.5	-3.0
Chest pain or discomfort	4.0	5.8	11.4	-1.6	-0.3	-1.9	-2.6	-2.2	-0.8	-2.4	-2.4	-2.9	-2.8	-3.2	-3.4	-2.9
Mouth/teeth dental problems: Dentures	3.9	6.7	15.2	-0.6	-1.1	-2.0	-3.2	0.2	2.1	-3.2	-3.4	-3.4	-2.0	-3.9	-3.1	-1.9
Wheeze or whistling in the chest in last year	3.7	6.5	14.4	-2.6	0.1	-1.9	-2.2	-1.9	-1.0	-0.6	-3.1	-2.7	-3.4	-3.8	-3.6	-2.9
Ulcerative Colitis	3.6	5.3	10.6	-2.4	-0.1	-1.4	-2.2	-2.0	0.0	-2.1	-3.2	-2.1	-3.1	-2.0	-3.1	-3.3
Worry (Nagel 2018)	3.5	7.5	13.6	0.7	2.7	2.5	3.0	3.1	1.6	2.7	1.5	3.2	3.2	2.9	3.7	3.2
Number of full sisters	3.5	4.2	14.4	-0.6	1.3	-1.9	-0.9	-3.8	-1.5	-3.0	-0.4	-1.3	-2.6	-1.6	-2.6	-2.2
Allergy or Eczema	3.4	8.9	26.5	-4.1	0.3	-3.1	-2.8	0.2	5.2	1.4	-2.5	-4.2	0.2	-4.7	0.1	-2.7
Qualifications: College or University degree	3.4	10.7	21.1	1.5	0.4	3.1	2.9	4.5	2.8	4.6	2.7	2.8	3.7	2.7	4.3	3.8
Smoking Status	3.2	7.6	15.0	-3.9	-0.5	-2.5	-2.7	-1.9	0.5	-2.1	-3.3	-3.5	-2.8	-3.2	-2.7	-3.6
Reproduciblity of spirometry measurement using ERS/ATS criteria	3.2	3.9	12.4	-0.6	-2.1	-3.4	-3.5	-1.7	-1.5	-1.5	-1.4	-1.9	-1.2	-1.5	-1.8	-1.4
Mean Putamen Volume	3.1	3.5	6.4	-0.7	0.1	-2.2	-2.0	-2.5	-0.9	-1.4	-1.4	-2.5	-2.0	-2.2	-2.4	-2.1
Hand grip strength (left)	3.1	8.1	24.8	-2.2	-2.7	-1.6	-0.5	-3.3	-1.8	-1.8	-2.8	-1.3	-5.0	-2.3	-4.1	-4.1
Hayfever, allergic rhinitis or eczema	3.1	6.7	16.3	-3.7	-0.1	-3.0	-2.5	0.3	4.0	0.9	-2.3	-4.0	0.4	-3.5	0.4	-2.8
Gout (self-reported)	3.1	4.2	21.2	0.5	-2.8	-1.0	1.0	-3.3	-4.6	-1.1	0.3	0.2	-1.9	1.0	-1.9	-1.9
Emphysema/chronic bronchitis	3.1	3.4	10.0	-1.7	0.4	-0.6	-1.6	-0.6	0.5	-1.8	-1.8	-2.3	-2.2	-3.2	-2.9	-1.8
Worrier / anxious feelings	2.9	5.5	11.6	0.4	2.6	3.4	2.6	3.1	2.2	2.2	0.3	2.0	2.6	1.4	2.5	2.7
Weight	2.8	13.9	89.1	1.7	-2.1	-0.3	1.3	-5.5	-9.4	-2.9	0.0	1.1	-4.2	2.7	-3.8	-2.0
Qualifications: NVQ or HND or HNC or equivalent	2.8	3.3	12.0	0.4	-1.9	-2.3	-2.0	-1.0	-2.7	-3.5	-1.4	-1.4	-0.7	-0.7	-1.5	-1.6
Allergy	2.7	6.2	15.4	3.4	-0.6	2.9	2.7	0.0	-3.1	-0.8	2.7	3.9	0.4	3.2	0.7	2.9
Hip circumference	2.7	11.8	87.2	1.8	-1.7	-0.4	0.3	-4.6	-9.3	-2.5	0.2	0.5	-3.3	2.5	-3.5	-1.7
Peak expiratory flow (PEF)	2.7	6.2	15.9	1.6	1.8	0.5	1.8	2.5	2.9	2.5	3.4	2.3	3.0	2.0	4.0	2.2
Current tobacco smoking	2.4	3.9	10.8	-1.4	0.3	-2.5	-2.3	-3.3	-1.9	-1.7	-1.5	-1.6	-1.9	-1.9	-2.0	-1.8
Qualifications: O levels/GCSEs or equivalent	2.4	3.9	8.9	0.7	1.6	1.6	1.3	2.0	1.2	2.3	0.7	2.0	2.7	2.1	3.0	2.5
Age at first live birth	2.4	4.2	8.8	1.7	-1.5	1.8	1.9	3.0	2.5	1.5	1.8	1.7	2.7	1.4	2.4	2.1
Osteoarthritis (self-reported)	2.4	3.1	10.2	-1.5	-1.2	0.3	0.1	-0.7	-1.8	-1.1	0.2	-2.4	-2.5	-1.9	-2.2	-3.2
Diastolic blood pressure, automated reading	2.4	7.3	19.2	2.0	0.2	2.4	2.8	1.9	0.6	3.4	1.7	4.4	2.1	3.8	3.0	3.4
Breast Cancer	2.3	5.6	17.8	2.7	-0.3	4.2	4.1	0.6	-2.6	1.0	2.5	3.0	-0.2	2.0	0.2	1.8
Waist Hip Ratio (WHR)	2.3	10.5	97.4	-3.9	0.7	-0.5	0.1	2.7	9.9	1.2	-1.5	-0.9	0.9	-2.1	2.4	-0.2
Alcohol drinker status: Previous	2.3	2.6	7.5	-1.3	-0.5	-2.2	-2.0	-1.7	-1.8	-2.7	-0.0	-1.9	-1.0	-1.0	-1.2	-1.5
Medication: Lansoprazole	2.2	2.6	6.2	0.4	-0.9	-1.1	-1.8	-0.4	-0.7	-2.5	-1.1	-2.0	-1.6	-1.5	-2.3	-2.4
Hand grip strength (right)	2.1	5.7	17.5	-1.4	-2.8	-1.1	-0.3	-3.0	-2.0	-1.1	-2.0	-0.8	-4.2	-1.6	-3.4	-3.6
Noisy workplace	2.1	2.6	8.4	-1.3	-1.7	-0.2	-0.9	-1.0	-0.7	-0.1	-2.9	-1.7	-1.9	-1.8	-2.3	-2.0
Medication: Atorvastatin	2.1	2.6	8.2	-0.8	-0.9	-1.9	-2.9	-0.9	0.5	-2.1	-1.0	-2.1	-1.1	-2.1	-1.5	-1.1
Deep venous thrombosis (DVT) (self-reported)	2.1	2.7	6.4	-0.0	2.5	-0.5	-2.4	-1.4	-1.3	-0.9	-1.0	-2.1	-1.4	-2.1	-2.3	-0.8
Other serious medical condition/disability diagnosed by doctor	2.0	2.6	7.8	-2.1	-0.4	-0.9	-1.5	-1.4	0.1	-2.0	-0.6	-2.8	-1.3	-1.9	-1.9	-1.8
Qualifications: A levels/AS levels or equivalent	2.0	4.5	8.6	0.6	1.7	2.7	1.5	2.4	2.8	2.9	1.2	2.4	1.5	2.1	2.5	2.1
Medication: Ibuprofen (e.g. Nurofen)	2.0	2.6	10.1	-0.4	-0.5	3.2	2.4	2.2	-0.2	2.2	0.5	1.2	1.3	0.9	1.3	1.3
Mouth/teeth dental problems: Bleeding gums	2.0	2.6	10.6	0.0	0.1	-0.4	-1.1	-0.8	-1.7	-3.3	-2.7	-0.8	-1.5	-0.9	-2.2	-1.5
Blood clot in the leg (DVT)	2.0	2.5	7.1	0.2	2.7	-0.5	-2.3	-1.5	-1.6	-0.8	-1.2	-1.8	-1.3	-1.7	-2.3	-0.6
Leg pain on walking	2.0	2.5	7.2	-1.8	-0.1	0.6	0.2	-1.1	-1.7	-0.5	-0.1	-2.4	-1.9	-1.8	-2.1	-2.7
Ever had stillbirth, spontaneous miscarriage or termination	2.0	2.1	8.5	-1.8	0.1	-1.0	-1.5	1.4	1.5	0.4	-0.2	-2.9	0.8	-2.5	0.2	-1.3
Medication: Omeprazole (e.g. Zanprol)	2.0	2.4	6.2	-2.1	-1.4	-0.4	0.2	0.3	0.1	-1.8	-2.1	-2.3	-1.5	-1.4	-1.3	-2.5
Lupus	1.9	2.8	11.7	-1.5	-0.8	-0.8	-0.8	-0.8	-0.5	-0.5	-0.2	-3.4	-1.4	-2.9	-1.7	-2.5
Sensitivity / hurt feelings	1.9	3.2	12.0	-0.9	3.5	1.0	0.2	2.4	3.0	1.9	0.3	0.1	1.9	0.0	2.0	1.4
Number of full brothers	1.9	2.4	7.4	-0.9	-0.1	-2.7	-2.2	-2.1	-1.4	-1.8	-1.1	-1.2	-1.1	-0.8	-1.2	-1.4
Suffer from ‘nerves’	1.9	2.9	6.2	0.7	2.5	1.4	1.4	1.9	0.7	1.2	1.1	2.4	1.6	1.8	2.1	2.0
Illnesses of father: Heart disease	1.9	2.6	8.2	2.3	-0.5	-0.3	1.7	-2.4	-1.2	0.1	0.8	2.9	0.5	2.5	0.7	1.5
Long-standing illness, disability or infirmity	1.9	2.9	8.8	-0.9	0.2	-1.5	-1.2	-2.2	0.1	-3.0	-1.2	-1.9	-1.9	-1.4	-2.0	-2.1
Commuting to job workplace: Public transport	1.9	2.3	7.6	0.6	2.8	1.7	1.6	0.5	-1.4	1.7	1.1	1.6	1.3	1.3	1.4	1.6
Hypothyroidism (self reported)	1.8	4.0	10.4	-2.0	-1.4	-0.9	-0.4	-1.6	-3.2	-2.2	-0.7	-2.2	-2.3	-0.6	-2.6	-3.1
Medication: Ibuprofen	1.8	2.1	8.4	-1.5	-0.6	2.9	1.9	2.4	0.8	2.1	0.3	0.4	0.8	0.3	1.1	0.4
Qualifications: nursing, teaching	1.8	2.8	7.4	0.3	0.1	0.5	0.7	2.2	2.0	2.5	2.7	0.9	1.8	0.9	2.3	1.3
Eye problems/disorders: Cataract	1.8	2.1	4.2	-0.1	-0.7	-1.4	-2.0	-1.1	-0.4	-1.2	-1.8	-1.4	-1.5	-2.0	-1.9	-1.4
HDL Cholesterol	1.7	2.9	6.9	1.5	1.1	1.5	2.3	1.3	0.0	1.7	0.4	2.6	1.3	1.9	1.9	2.6
Rheumatoid Arthritis	1.7	2.3	6.5	-0.5	0.1	0.5	-0.5	-0.1	-1.8	-1.9	-1.9	-2.0	-1.9	-1.0	-2.5	-2.0
Tinnitus: Yes, but not now, but have in the past	1.7	1.8	7.8	0.1	0.2	2.2	1.5	2.8	1.5	1.9	0.8	0.2	0.8	-0.0	0.8	0.7
Time employed in main current job	1.7	1.9	4.2	2.0	0.7	2.0	1.6	1.0	0.8	0.4	2.1	1.7	0.4	1.1	0.6	1.7
Loud music exposure frequency	1.7	1.8	3.8	-0.7	0.5	1.5	1.7	1.9	1.2	1.6	0.7	1.2	1.6	1.1	1.8	1.1
Depression (Nagel 2018)	1.6	2.4	5.7	-1.4	2.4	-2.1	-2.4	-1.4	-0.1	-0.4	-1.2	-1.3	-1.0	-1.9	-1.8	-0.8
Blood Eosinophil Count	1.6	12.6	28.0	1.0	1.4	2.8	2.7	4.8	5.2	5.3	1.1	3.5	3.5	2.5	4.5	3.8
Respiratory disease	1.6	3.6	9.4	-3.1	1.1	-2.3	-2.6	-0.6	2.7	0.9	-0.9	-2.0	-1.1	-2.3	-0.7	-2.0
Frequency of unenthusiasm / disinterest in last 2 weeks	1.6	2.2	4.0	-1.3	2.0	-1.3	-2.0	-0.7	-1.1	-1.9	-1.3	-1.7	-0.9	-1.4	-1.7	-1.2
Medication: Levothyroxine sodium	1.6	2.8	7.8	-2.3	-2.4	-0.2	-0.0	-0.7	-1.3	-1.6	-0.9	-2.0	-1.7	-0.9	-2.0	-2.8
Chronic bronchitis/emphysema (father)	1.6	1.9	5.3	-0.2	0.6	0.5	-0.1	-1.9	-0.9	-0.2	-1.4	-1.3	-2.1	-2.1	-2.3	-1.3
Had menopause	1.6	2.0	5.6	-0.7	0.4	0.6	-0.2	-1.2	-0.9	-0.4	-1.1	-2.3	-1.9	-2.0	-2.4	-1.8
Qualifications: None of the above	1.6	3.4	9.6	-1.4	0.1	0.0	0.4	-2.1	-1.4	-1.9	-0.7	-1.8	-3.1	-1.6	-2.8	-3.0
Hair/balding pattern: Pattern 3	1.6	2.4	4.8	0.3	0.8	2.0	1.4	2.2	1.5	1.7	-0.2	1.6	1.8	1.3	1.6	2.1
Happiness	1.6	1.9	7.6	0.2	1.8	0.3	0.1	1.3	2.8	0.4	-0.5	1.0	2.0	0.3	1.2	2.2
Medication: Omeprazole	1.6	2.0	5.0	-2.0	-1.4	-0.4	0.1	0.6	0.5	-1.0	-2.2	-1.9	-1.3	-1.6	-1.1	-1.9
Medication: Seretide 50 evohaler	1.6	1.8	4.3	0.4	-1.4	-0.7	-1.2	-1.5	-2.1	-1.1	-1.7	-0.7	-1.8	-0.5	-1.8	-1.2
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	7.9	0.0	1.5	1.7	1.8	1.6	0.9	2.8	1.5	-0.3	1.0	0.0	1.2	-0.0
Ever taken oral contraceptive pill	1.6	1.7	5.5	-2.4	0.2	-0.9	-0.3	2.2	1.7	1.7	-0.7	-0.4	1.3	-0.3	1.8	-0.3
Financial situation satisfaction	1.6	2.0	4.0	-0.5	-0.4	-1.8	-2.0	-1.4	0.3	-1.9	-1.2	-1.9	-1.1	-1.6	-1.6	-1.2
Bipolar Disorder (2018)	1.5	2.3	5.7	-1.5	1.4	-2.1	-2.4	-1.5	1.9	1.0	-1.5	-1.1	0.1	-2.1	-0.4	0.1
Hearing difficulty/problems with background noise	1.5	2.3	6.0	-2.3	0.6	-0.2	0.6	2.4	1.9	1.6	-0.5	-2.0	-0.1	-2.1	0.0	-1.9
Medication: Ramipril	1.5	1.9	9.7	-0.2	0.9	-3.1	-2.6	-1.9	0.3	-1.6	0.5	0.7	-0.6	0.3	-0.2	0.5
Frequency of tiredness / lethargy in last 2 weeks	1.5	2.5	4.6	-1.2	2.1	-1.4	-1.4	-1.1	-0.6	-1.6	-0.0	-2.0	-1.6	-2.1	-2.1	-1.8
Number of live births	1.5	2.1	6.7	-1.9	0.6	-0.6	-0.9	-0.7	0.6	-0.4	-0.7	-2.2	-1.5	-2.6	-1.8	-1.6
Birth weight of first child	1.5	2.7	15.9	0.4	-2.1	-0.2	0.4	-2.0	-4.0	-1.7	-0.9	-0.8	-1.0	0.8	-1.9	-0.8
Medication for cholesterol, blood pressure or diabetes	1.5	2.4	7.3	-0.1	0.1	2.7	2.6	1.5	-0.1	2.2	1.8	0.3	1.4	1.1	1.9	0.4
Comparative height size at age 10	1.5	8.1	49.1	1.4	-1.8	0.3	1.7	-3.0	-7.0	-2.4	0.4	2.4	-3.5	3.3	-2.1	-0.7
Friendships satisfaction	1.5	1.9	4.4	0.3	1.9	0.3	0.1	1.1	2.1	1.9	1.3	0.6	1.9	0.2	1.8	1.7
Smoking status: Current	1.5	2.4	7.3	-1.4	0.5	-1.8	-1.5	-2.7	-1.5	-1.3	-1.7	-1.1	-1.5	-1.3	-1.5	-1.4
Average weekly beer plus cider intake	1.5	2.2	6.5	-1.9	-0.2	0.8	0.7	-0.2	-2.5	0.3	-1.1	-0.9	-2.4	-0.7	-2.0	-2.3
Ever had prostate specific antigen (PSA) test	1.5	1.7	4.8	-2.2	1.3	0.4	2.0	1.1	1.7	2.1	-0.1	0.8	0.5	-0.4	1.4	0.1
Triglycerides	1.4	2.3	6.2	-1.9	0.2	-0.5	-0.9	-0.4	0.0	-1.7	-0.5	-1.9	-2.5	-1.1	-2.2	-2.5
Diabetes (father)	1.4	1.7	5.8	-0.2	-0.6	-0.7	-0.5	-2.4	-1.6	-1.9	-0.2	-0.1	-2.1	-0.0	-1.7	-1.5
Body mass index (BMI)	1.4	6.2	36.7	1.1	-1.6	-0.2	0.9	-3.7	-6.1	-2.0	-0.0	0.1	-2.8	1.3	-2.9	-1.7
Waist circumference	1.4	5.1	17.9	-0.5	-1.4	-1.1	0.2	-3.7	-4.2	-2.3	-1.0	-0.2	-3.4	1.0	-2.9	-2.1
Illnesses of mother	1.4	1.8	5.0	-1.7	-0.1	-1.0	-1.3	0.8	0.5	0.3	-1.0	-2.2	-1.3	-2.2	-0.9	-1.8
Hypothyroidism/myxoedema (self-reported)	1.4	2.8	5.9	-1.6	-1.9	0.2	0.3	-1.0	-2.4	-2.2	-0.4	-1.6	-2.0	-0.3	-2.2	-2.4
Chronic bronchitis/emphysema (mother)	1.4	1.6	3.5	-0.8	1.8	-0.6	-0.9	-1.3	-0.7	-1.0	-0.6	-1.3	-1.4	-1.6	-1.9	-1.5
Forced expiratory volume in 1-second (FEV1), predicted percentage	1.4	2.9	8.5	1.4	-0.6	0.1	1.2	2.1	1.2	1.2	2.9	1.7	2.4	0.9	2.5	1.6
Arm fat mass (left)	1.4	5.8	33.4	1.1	-0.7	0.4	1.8	-3.9	-5.8	-1.5	-0.1	1.0	-2.4	2.7	-2.2	-1.1
Wears glasses or contact lenses	1.4	1.6	9.0	-0.6	-0.1	-0.3	0.3	1.3	3.0	1.1	0.5	0.2	1.6	0.5	2.1	1.1
Fasting Glucose	1.3	1.6	4.8	-1.1	-0.1	-0.9	-1.1	-0.5	0.0	-1.8	-0.7	-0.9	-2.2	-1.1	-1.5	-2.0
BMI	1.3	7.3	41.0	2.3	-2.4	-0.4	1.0	-3.5	-6.4	-3.3	-0.4	0.6	-2.0	2.6	-2.6	-1.0
Lung FEV1/FVC ratio	1.3	6.5	21.3	-0.1	-0.1	1.4	1.9	3.8	4.6	1.4	0.6	1.7	4.2	0.7	4.1	1.6
Relative age of first facial hair	1.3	2.6	6.4	-1.7	-0.2	-1.5	-1.0	-2.1	-0.7	-1.6	-0.9	-1.7	-1.6	-2.5	-1.8	-2.2
Ever had hysterectomy (womb removed)	1.3	1.5	7.5	0.2	0.7	0.9	0.1	-0.3	-2.7	-0.7	1.8	0.7	-0.4	2.3	-0.2	0.5
Qualifications: CSEs or equivalent	1.3	1.8	5.7	-0.5	0.4	-1.9	-1.2	-2.3	-2.4	-2.4	-0.3	-0.5	-0.0	0.3	-0.5	-0.3
Hayfever/allergic rhinitis (self-reported)	1.3	1.7	4.0	-1.1	-2.0	-1.9	-1.3	-0.3	1.6	0.4	-1.1	-1.4	-0.7	-1.5	-0.4	-1.5
Arm fat mass (right)	1.3	5.2	31.1	1.1	-0.7	0.7	2.0	-3.5	-5.6	-1.2	-0.1	1.0	-2.1	2.7	-1.9	-1.0
Breastfed as a baby	1.3	1.6	5.4	-0.3	-2.1	-2.3	-1.7	-1.8	0.3	-1.6	-1.0	-0.5	-0.8	-0.5	-0.5	-0.2
Shortness of breath walking on level ground	1.3	1.5	3.6	-1.6	-0.6	0.8	1.5	0.6	-0.9	-0.6	-1.7	-0.0	-1.9	0.1	-1.5	-1.9
Leg fat mass (right)	1.3	4.9	18.2	0.6	-1.0	-1.2	-0.2	-3.8	-4.3	-1.9	-1.4	-0.5	-2.9	0.5	-3.0	-2.1
Handedness (chirality/laterality): Left-handed	1.3	1.6	4.5	-1.8	-0.6	-0.1	0.4	-1.0	-0.1	-0.3	-1.3	-1.8	-1.0	-2.1	-1.1	-2.0
Illnesses of father: None of the above (group 1)	1.3	1.6	4.3	-1.9	-0.3	-1.8	-1.8	1.0	1.2	0.2	0.7	-2.1	0.2	-1.2	0.6	-1.2
Ever depressed for a whole week	1.3	1.6	8.5	-0.5	1.9	-0.4	-0.8	0.4	2.9	1.2	1.1	-0.4	0.9	-1.6	1.0	0.1
Unable to work because of sickness or disability	1.3	1.7	4.0	-1.5	-0.1	-0.5	-0.4	-1.9	-0.7	-0.8	-0.2	-1.7	-1.9	-1.0	-2.0	-1.9
Basal cell carcinoma (self-reported)	1.3	1.5	3.9	0.6	-1.2	0.7	1.3	1.4	-0.4	1.0	-0.1	0.5	1.9	2.0	1.7	1.1
Leg fat mass (left)	1.3	5.2	20.8	0.7	-1.2	-1.2	-0.2	-3.9	-4.6	-2.2	-1.3	-0.3	-2.9	0.8	-3.0	-1.9
Bipolar Disorder or Schizophrenia	1.2	2.9	7.9	-2.8	2.5	-1.7	-1.7	-0.9	2.6	2.1	-1.0	0.4	0.3	-2.0	0.6	0.4
Diabetes (mother)	1.2	1.6	3.8	-0.9	-0.2	-0.6	-0.6	-1.8	-0.3	-1.9	-1.4	-1.1	-1.3	-1.3	-1.7	-1.5
Fed-up feelings	1.2	2.2	11.2	-0.7	2.3	-0.3	-1.8	-0.1	0.3	-0.9	-3.4	-0.8	-0.8	-1.8	-1.5	-0.6
Alcohol usually taken with meals	1.2	2.0	6.2	0.5	1.3	-0.0	0.4	2.3	2.5	-0.3	1.0	1.2	1.8	1.1	1.9	1.4
Worry too long after embarrassment	1.2	1.9	8.2	-0.3	2.3	0.8	-0.1	1.7	2.9	1.8	0.2	0.2	1.1	-1.2	1.1	1.1
Eye problems/disorders: None of the above	1.2	1.3	6.1	-0.6	1.4	1.2	2.5	-0.3	-1.3	0.7	1.0	1.5	-0.3	1.3	0.5	-0.0
Supplements: Vitamin C	1.2	1.4	4.7	0.4	0.3	1.3	0.9	2.2	1.9	1.3	1.0	1.8	0.4	0.4	0.8	0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	1.2	1.4	3.1	-0.1	-1.7	-1.3	-0.9	-0.1	-0.2	-1.4	-1.3	-0.6	-1.8	-1.1	-1.4	-1.7
Medication for cholesterol	1.2	1.8	5.9	-0.1	0.5	0.6	0.2	-0.9	-2.2	-0.5	-2.4	0.2	-2.1	-1.1	-2.1	-0.8
Eye problems/disorders: Glaucoma	1.2	1.4	3.5	0.8	-1.7	-0.5	-0.1	0.9	1.7	0.2	1.4	-0.1	1.9	1.0	1.8	1.4
Risk taking	1.2	1.7	5.6	-1.6	-0.3	-1.8	-2.4	0.8	1.1	-0.6	-1.5	-1.7	-0.8	-0.4	-0.3	-1.7
Pain experienced in last month	1.2	1.9	7.6	1.1	-1.3	-2.5	-2.8	-1.3	0.8	-1.6	-1.6	0.3	-0.4	-0.5	-0.6	0.1
Neuroticism (Nagel 2018)	1.1	2.5	9.4	0.0	3.1	0.7	-0.3	1.6	2.0	1.5	-0.4	1.1	2.1	0.4	1.7	2.2
Primary Biliary Cirrhosis	1.1	1.6	4.9	-1.8	0.2	-0.2	-1.3	-1.0	-0.2	-0.3	0.5	-1.2	-2.2	-1.4	-1.2	-2.2
Blood Platelet Count	1.1	13.0	40.3	-3.0	1.5	-1.2	-4.0	2.9	6.3	-0.3	-4.4	-5.5	0.2	-5.9	-1.6	-2.2
Height	1.1	22.0	151.3	1.7	-0.7	-0.8	0.8	-7.3	-12.3	-3.7	1.9	2.5	-4.9	4.2	-3.4	-1.1
Tanning	1.1	13.5	67.6	-3.9	-1.1	-5.3	-3.7	-0.6	8.2	1.4	0.3	-2.8	-0.4	-5.9	1.1	-1.8
Frequency of depressed mood in last 2 weeks	1.1	1.6	4.9	-0.7	2.2	-1.4	-2.1	-0.5	1.3	-0.7	-1.4	-0.2	-0.6	-1.6	-1.1	-0.1
Age when periods started (menarche)	1.1	2.7	6.5	-1.2	0.3	-1.5	-1.3	-2.3	1.5	-1.1	-1.0	-2.2	-1.5	-2.6	-2.0	-1.7
Bilateral oophorectomy (both ovaries removed)	1.1	1.2	2.5	-1.4	0.3	-0.0	-0.4	-1.3	-1.4	-1.4	1.5	-1.0	-1.2	-0.0	-0.9	-1.6
Supplements: Glucosamine	1.1	1.5	6.9	-1.3	-0.4	0.3	1.1	1.2	0.9	2.6	1.7	0.3	0.4	0.1	1.8	0.2
Sitting height	1.1	7.9	48.0	2.2	-1.4	0.6	0.8	-3.2	-6.9	-1.9	-2.0	2.2	-2.9	3.0	-2.7	0.1
Had other major operations	1.1	1.4	5.1	0.6	-0.6	-1.3	-0.9	-2.3	-1.6	-1.6	0.6	-0.8	-0.8	-0.1	-1.3	-1.1
Neuroticism score	1.1	2.2	14.8	-0.5	3.8	1.0	0.1	1.7	2.1	0.7	-0.9	0.7	1.1	-0.1	1.1	1.3
Falls in the last year	1.1	1.5	4.4	-1.9	-0.0	-0.9	-0.9	-1.8	-0.2	-0.8	-0.6	-2.1	-1.0	-1.5	-1.0	-1.3
Seen a psychiatrist for nerves, anxiety, tension or depression	1.1	1.4	6.1	0.0	0.4	-1.3	-2.5	-0.8	0.1	-1.1	-0.6	-1.6	-0.4	-2.0	-1.1	-0.5
Heart disease (mother)	1.1	1.3	5.3	2.3	-1.5	1.5	1.3	0.3	-0.2	-1.0	0.0	1.2	1.0	0.6	0.3	1.4
Asthma (self-reported)	1.1	2.2	6.3	-1.7	1.2	-2.5	-2.3	0.0	2.1	1.5	-0.9	-1.5	0.1	-1.5	0.3	-0.9
High cholesterol (Self-reported)	1.1	2.0	7.6	-0.5	-0.4	-1.5	-2.7	0.1	0.7	-0.9	-0.4	-2.1	-0.3	-2.8	-1.1	-1.1
HbA1C	1.0	1.1	5.3	-0.2	1.3	0.4	-0.7	0.4	0.0	0.4	-0.8	-1.2	-0.9	-2.3	-1.0	-1.4
Hearing difficulty/problems: Yes	1.0	1.5	7.0	-1.4	2.1	-0.3	0.5	1.3	2.6	1.5	0.2	-0.0	-0.3	-1.0	0.3	-0.6
Taking other prescription medications	1.0	1.6	3.9	-1.2	-0.3	-0.8	-0.5	-1.5	-1.1	-1.4	-0.6	-2.0	-1.1	-1.1	-1.6	-1.9
Hair/balding pattern: Pattern 2	1.0	1.3	5.8	-0.6	-0.4	-2.1	-2.4	-1.5	-0.1	-1.6	-0.6	-0.3	-0.5	-0.6	-0.7	-0.2
Asthma	1.0	2.0	5.2	-1.5	1.3	-2.3	-2.1	0.1	2.2	1.7	-0.7	-1.4	-0.0	-1.6	0.2	-0.8
Standing height	1.0	9.5	57.3	1.8	-1.3	0.0	1.2	-4.4	-7.6	-2.0	0.0	2.7	-3.5	3.4	-2.2	-0.4
Medication: Ventolin 100micrograms inhaler	1.0	1.3	7.2	-1.1	-0.3	-0.5	-0.8	-0.6	-0.3	0.1	-2.7	-1.2	-1.0	-0.8	-1.4	-1.4
Comparative body size at age 10	1.0	2.8	8.5	2.9	-0.7	1.9	1.5	1.9	-1.8	0.6	1.4	1.6	1.5	1.6	0.9	1.9
Knee pain experienced in last month	1.0	1.5	5.4	-1.5	-1.9	0.2	0.6	-1.2	-2.3	-0.5	0.2	-0.8	-1.5	-0.2	-0.9	-1.4
Forced expiratory volume in 1-second (FEV1), predicted	1.0	2.0	12.7	1.2	0.1	0.4	0.4	-1.7	-3.6	-1.0	-0.3	1.4	-1.6	1.3	-1.3	-0.1
Number of self-reported non-cancer illnesses	1.0	1.7	4.2	-1.6	-0.3	-2.0	-1.8	-0.7	0.9	-0.9	-0.5	-1.8	-0.8	-1.3	-1.0	-1.5
Average weekly champagne plus white wine intake	1.0	1.4	3.9	-1.0	-0.7	1.3	1.4	1.7	0.8	2.0	1.3	0.6	0.8	0.7	1.5	0.1
Guilty feelings	1.0	1.5	5.9	-1.7	2.0	-1.3	-0.5	-2.4	-1.0	0.3	-1.0	0.5	-1.4	-0.8	-0.6	-0.5
Medication: Paracetamol	1.0	1.5	5.0	-2.0	0.6	2.2	1.2	0.7	1.0	0.2	-1.1	-0.8	-1.0	-1.3	-1.0	-1.0
Illnesses of father: High blood pressure	1.0	1.2	3.0	0.5	0.5	1.7	0.6	1.7	-0.1	1.5	-0.6	1.2	1.4	0.2	0.8	1.4
Coronary Artery Disease (CAD)	0.9	1.1	4.6	0.0	0.9	1.4	1.1	1.6	0.0	1.6	0.5	2.1	0.0	0.0	0.0	0.0
LDL Cholesterol	0.9	1.4	2.8	-0.7	0.6	-1.6	-1.7	-0.7	0.0	-1.0	-1.6	-1.6	-0.8	-1.3	-1.2	-1.2
Schizophrenia (2014)	0.9	1.9	5.4	-1.8	1.8	-1.1	-0.9	-0.9	0.0	2.3	0.0	2.3	0.6	0.2	1.7	1.4
Neuroticism	0.9	2.3	6.9	-0.3	2.6	1.0	0.3	2.0	2.6	1.4	-0.7	0.9	1.5	0.2	1.4	1.8
Ever used hormone-replacement therapy (HRT)	0.9	1.1	3.4	-1.8	-0.2	0.7	1.1	-0.8	-1.2	0.3	-0.6	-1.2	-1.3	-0.4	-1.0	-1.6
Stomach or abdominal pain in last month	0.9	1.2	6.4	0.5	1.6	0.9	0.5	1.6	2.5	0.1	0.1	0.5	0.8	-0.7	0.6	0.8
Lung cancer (father)	0.9	1.0	2.8	-0.9	-1.0	-1.0	-1.6	-0.1	-0.3	-1.2	-0.1	-1.7	-0.4	-1.0	-0.8	-1.1
Headache pain in last month	0.9	1.5	4.3	-0.9	1.9	0.7	0.3	2.0	0.9	1.3	0.8	-0.7	2.1	0.1	1.5	0.5
Number of children fathered	0.9	1.0	2.9	-0.9	-1.3	-1.5	-0.0	-1.7	-0.9	0.0	0.3	-0.0	-1.4	-0.3	-0.4	-1.4
Whole body fat mass	0.9	3.9	18.6	0.8	-0.5	-0.3	1.1	-3.7	-4.3	-1.4	-0.8	0.5	-2.1	2.1	-1.9	-1.2
Age at last live birth	0.9	1.3	5.6	-0.2	-1.1	1.4	1.1	1.7	2.4	1.1	0.1	0.2	1.1	-0.9	0.7	0.5
Breast cancer (self-reported)	0.9	1.0	4.0	-0.3	-1.2	-2.0	-1.6	-1.9	0.5	-0.6	-0.0	0.1	-0.7	-0.4	-0.3	0.3
Medication: Gliclazide	0.9	1.0	3.4	-1.0	1.3	-0.7	-1.2	-0.6	0.9	-1.0	-1.9	-0.4	-0.7	-0.4	-1.2	-0.4
Miserableness	0.9	1.5	5.7	-0.8	2.2	-1.0	-2.4	0.4	0.9	-1.0	-1.8	-0.8	-0.0	-1.2	-0.5	0.1
Intelligence (Savage-Jansen 2018)	0.8	2.4	6.4	2.5	1.2	1.1	0.8	0.2	-0.3	1.1	2.0	2.0	1.0	1.9	1.1	2.5
Schizophrenia (2018)	0.8	1.7	6.0	-2.4	2.1	-0.5	-0.3	0.0	1.9	1.9	-0.0	1.4	0.3	-0.9	1.1	0.4
Average weekly spirits intake	0.8	1.0	3.8	0.9	-0.3	-0.5	0.2	-0.9	1.6	-0.3	1.3	1.9	-0.0	0.8	0.8	1.3
Eye problems/disorders: Diabetes related eye disease	0.8	0.8	2.7	1.6	-0.2	0.9	0.6	0.5	0.4	1.6	0.9	1.0	0.5	0.6	0.5	1.1
Trunk fat mass	0.8	3.3	13.6	1.0	-0.3	-0.0	1.4	-3.4	-3.7	-0.9	-0.7	1.1	-1.4	3.0	-1.2	-0.5
Fluid intelligence score	0.8	1.7	4.8	2.2	1.1	0.8	0.9	0.5	-0.7	1.3	1.4	2.1	0.3	1.8	0.8	1.4
Forced expiratory volume in 1-second (FEV1)	0.8	2.7	7.8	1.5	-0.4	1.1	2.3	1.2	-0.3	1.7	2.8	2.3	1.3	1.3	2.1	1.1
Medication: Cholesterol lowering	0.8	1.2	2.4	-0.0	-1.0	-1.5	-1.4	-0.5	0.7	-1.6	-1.4	-0.4	-1.0	-1.4	-1.5	-0.4
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.6	4.9	1.7	-0.9	1.3	2.0	1.4	-1.0	1.2	2.2	2.2	1.7	1.4	1.9	1.2
Pulse wave reflection index	0.8	0.9	6.1	0.0	-1.1	-1.7	-2.5	-0.0	0.1	-0.9	0.1	-0.5	0.3	-0.5	0.1	0.6
Ever highly irritable/argumentative for 2 days	0.8	0.9	5.2	-1.4	2.3	-0.2	-0.1	-0.8	-0.7	-0.2	0.2	0.4	-1.5	-0.2	-0.8	-0.8
Mouth/teeth dental problems: Loose teeth	0.8	1.0	3.1	-0.7	-0.1	-0.8	-1.6	0.3	-0.2	-0.4	-1.7	-1.6	0.1	-1.8	-0.5	-0.5
Medication: Blood pressure	0.8	1.4	5.8	-0.3	0.5	-2.4	-2.3	-1.0	0.5	-1.7	-1.2	-0.0	-0.8	-0.4	-0.9	-0.1
Commuting to job workplace: Car/motor vehicle	0.8	0.9	3.0	-0.3	-0.1	-0.3	-0.4	-0.6	1.3	-1.1	-0.2	-1.6	-0.7	-1.7	-0.8	-1.5
Mood swings	0.8	1.5	11.8	0.8	3.4	0.9	-1.2	1.1	0.9	-0.3	-1.0	-0.2	0.1	-0.7	-0.5	0.9
Commuting to job workplace: Walk	0.8	0.9	3.2	0.8	0.5	1.2	1.0	-0.3	0.3	-0.5	-0.7	1.8	0.2	1.5	0.7	0.9
Back pain experienced in last month	0.8	1.2	2.8	-0.8	0.4	0.6	1.6	-0.2	-1.1	0.3	1.5	0.7	1.4	1.5	1.7	0.7
Tinnitus: Yes, now most or all of the time	0.8	0.9	2.0	0.7	-1.0	-0.8	0.6	1.2	1.1	1.1	0.7	0.3	1.4	0.9	1.4	0.4
Commuting to job workplace: Cycle	0.8	0.9	2.7	0.4	-0.7	-0.4	-0.4	0.9	1.4	0.6	0.4	1.4	1.0	1.1	1.1	1.6
Heart disease (siblings)	0.8	1.0	3.0	0.2	-0.8	-0.0	1.0	-0.9	-1.0	-1.7	-1.5	0.7	-1.2	-0.0	-1.1	-0.8
Depressed Affect (Nagel 2018)	0.7	1.6	7.0	-0.0	1.9	-1.1	-2.6	-0.0	0.5	-0.8	-2.1	-1.1	0.0	-1.2	-0.9	0.1
Schizophrenia vs Biploar Disorder	0.7	0.9	3.7	0.7	0.1	0.7	0.8	0.5	0.0	0.3	0.8	1.9	0.9	1.4	1.3	1.0
Alzheimer’s Disease (in mother)	0.7	0.8	1.7	-0.9	-0.9	-0.8	-0.8	-0.2	-0.9	-0.9	-1.0	-0.4	-1.2	0.1	-1.1	-1.3
Alzheimer’s Disease (in father)	0.7	0.7	2.5	0.1	0.8	1.1	0.7	-0.2	-0.6	0.6	1.6	0.6	0.7	1.2	0.9	0.9
Neuroticism (2016)	0.7	1.1	3.0	-0.4	1.7	0.4	-0.3	1.6	0.6	0.7	1.3	-0.4	1.7	-0.7	1.0	0.8
Blood Red Count	0.7	6.5	42.0	-0.4	-0.3	-0.6	-1.6	6.5	5.5	-2.1	-1.6	-0.7	0.2	-1.3	0.9	0.3
Systolic Blood Pressure	0.7	3.7	13.5	1.1	-1.2	-1.0	-0.7	1.7	3.7	1.9	1.6	0.2	2.9	1.3	3.1	1.5
Supplements: Zinc	0.7	0.7	2.8	-1.0	0.5	0.7	0.0	0.7	-0.2	0.4	-0.2	-0.9	-1.2	-0.9	-1.0	-1.7
Townsend deprivation index at recruitment	0.7	0.9	2.2	-0.8	1.3	-0.9	-0.8	-0.0	0.1	-1.3	-0.9	-0.3	-1.5	-0.8	-1.1	-1.4
Maternal smoking around birth	0.7	1.1	4.2	-0.5	-1.2	-2.0	-0.5	-1.8	-0.7	0.1	-1.7	0.1	-0.7	0.1	-0.4	-0.4
Relative age voice broke	0.7	1.1	3.8	-0.6	1.7	-1.2	-1.4	-0.8	0.2	0.5	-0.4	-0.9	-0.6	-1.9	-0.7	-1.0
Heel bone mineral density (BMD) T-score, automated (left)	0.7	1.7	6.3	1.8	0.5	-1.1	0.4	-2.3	-0.9	-0.8	2.5	1.4	-0.5	0.9	0.0	0.8
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	6.5	-0.9	2.5	-0.2	-0.7	-0.9	0.5	-0.7	-0.9	-0.0	-1.2	-1.1	-1.1	-0.2
Heel bone mineral density (BMD) T-score, automated (right)	0.7	1.6	6.2	1.5	1.2	-1.5	-0.2	-2.2	-1.2	-0.7	2.5	0.5	-0.8	0.2	-0.4	0.1
Medication: Paracetamol	0.7	1.1	4.6	-1.5	0.8	2.1	1.2	0.8	-0.1	0.3	-1.2	-0.7	-0.8	-0.9	-0.9	-0.9
Neck or shoulder pain in last month	0.7	1.1	3.0	-1.5	1.0	1.1	0.2	0.2	0.2	1.0	0.2	-1.5	-0.6	-1.7	-1.0	-1.2
Medication: Aspirin	0.7	0.9	4.0	0.5	-1.4	-1.1	-0.2	-0.2	2.0	-0.9	-1.1	1.0	0.2	0.2	0.2	1.2
Loneliness, isolation	0.7	1.0	3.5	1.0	1.4	-0.8	-1.9	-0.4	-0.4	-1.6	-1.0	-0.7	0.5	-0.3	-0.5	0.7
Ever had bowel cancer screening	0.7	0.8	3.7	-0.2	0.3	-0.7	-0.6	-0.4	-1.9	-1.5	-0.8	-0.8	-0.6	-0.2	-0.7	-1.0
Medication: Aspirin	0.7	0.9	4.3	0.4	-1.1	-1.3	-0.5	-0.4	2.1	-1.4	-1.1	0.4	-0.3	-0.4	-0.3	0.8
Hearing aid user	0.7	0.7	2.7	-1.0	-0.2	0.2	0.7	-0.2	-0.1	-0.2	-0.2	-0.5	-1.6	-1.1	-1.2	-1.6
Medication: Blood pressure	0.7	1.3	4.1	1.2	-0.4	-1.0	-0.8	-0.0	0.2	0.3	1.9	0.4	1.6	2.0	1.3	1.2
Irritability	0.7	1.2	5.8	0.5	2.4	0.9	-0.9	1.4	1.9	-0.5	-0.6	0.1	0.5	-1.2	0.2	0.8
Age started oral contraceptive pill	0.7	0.9	3.0	0.8	-1.7	1.6	0.8	0.9	0.2	-0.1	-0.5	0.5	1.0	1.0	0.7	1.1
Pack years of smoking	0.7	1.1	2.4	0.0	-0.9	0.1	0.3	-1.5	-1.5	-1.3	-1.6	0.5	-1.2	0.5	-1.5	-0.3
Age at First Birth	0.6	0.9	5.0	0.3	-0.6	-0.1	0.5	-1.2	0.0	-0.7	0.5	1.1	0.4	2.2	0.8	1.0
Lung FVC	0.6	3.1	10.4	1.4	-1.6	2.0	3.2	1.7	-0.4	2.2	2.9	1.7	0.8	-0.1	1.3	0.5
Hair Pigment	0.6	15.9	63.8	1.0	-1.0	-5.0	-8.0	-2.5	-3.4	-4.3	-3.1	-4.8	-2.1	-4.2	-4.6	-1.7
Number of incorrect matches in round	0.6	0.9	3.4	0.1	-0.6	-0.4	0.2	-0.8	-1.5	-1.4	1.5	1.9	-0.8	0.8	-0.1	0.2
Diabetes (self-reported)	0.6	0.9	7.7	0.2	0.2	-0.6	-0.9	0.3	2.8	-0.6	-1.0	0.2	0.6	0.2	0.3	0.9
Illnesses of siblings	0.6	0.9	4.2	0.7	1.1	0.8	-0.1	2.0	1.0	0.5	0.5	-0.1	1.4	0.2	1.1	0.8
Alcohol intake versus 10 years previously	0.6	0.9	3.7	-0.0	0.9	-0.5	-0.8	-0.9	-1.9	-1.0	-0.9	-0.6	-1.1	-0.1	-1.4	-0.9
Father’s age at death	0.6	0.9	2.1	-0.5	1.1	1.2	1.4	0.7	0.4	1.4	-0.9	0.2	-1.2	-0.8	-0.7	-0.4
Pulse wave Arterial Stiffness index	0.6	0.7	3.0	-0.4	-0.3	-1.7	-1.5	0.0	1.0	-0.3	-0.5	-0.1	0.7	0.7	0.6	0.5
Length of working week for main job	0.6	0.7	2.6	0.7	-1.1	0.1	-0.9	-0.8	-0.7	-1.6	-0.2	-0.8	-0.4	-0.7	-0.9	-0.1
Hair/balding pattern: Pattern 4	0.6	1.5	5.4	0.9	-0.9	1.1	2.3	-0.5	-0.6	1.7	2.3	1.2	-0.4	0.5	-0.0	0.4
Glaucoma (self-reported)	0.6	0.7	1.9	-0.3	-1.4	-0.7	-0.4	0.5	1.3	-0.2	1.2	-1.2	0.8	-0.1	0.9	0.0
Leg fat percentage (right)	0.6	2.3	5.7	-1.3	-0.2	-1.7	-0.9	-2.1	0.2	-0.4	-1.7	-1.8	-1.9	-1.1	-1.9	-2.4
Reason for reducing amount of alcohol drunk: Health precaution	0.6	0.7	2.5	0.7	-0.4	-0.6	0.3	-0.4	-0.7	0.6	0.2	1.6	0.6	1.5	1.1	0.8
Pulse wave peak to peak time	0.6	0.7	3.3	0.6	0.3	1.8	1.6	-0.2	-1.4	0.3	0.5	0.5	-0.6	-0.3	-0.5	-0.3
Pulse rate, automated reading	0.6	1.8	6.1	-0.5	0.8	2.0	2.0	1.3	1.7	2.5	-0.4	0.8	1.0	0.7	0.9	1.0
Overall health rating	0.6	1.3	3.9	-0.9	1.6	0.8	0.8	-0.8	-0.1	-1.3	-1.4	-0.8	-1.3	-0.9	-2.0	-1.2
Family relationship satisfaction	0.6	0.7	1.7	0.8	1.3	-0.9	-1.1	0.2	1.1	-0.6	0.7	0.3	0.9	0.2	0.6	1.3
Mother’s age at death	0.6	0.7	4.7	-0.9	0.7	0.3	0.7	0.5	2.2	0.9	-0.4	0.9	-0.2	-0.1	0.6	0.6
Medication: Lisinopril	0.6	0.8	2.5	1.1	0.5	0.4	0.3	1.0	0.9	-0.7	0.7	0.9	1.1	0.7	0.8	1.6
Number of operations (self-reported)	0.6	0.9	2.9	0.2	-1.5	-0.5	-1.1	-0.5	-1.0	-1.0	0.1	-1.7	-0.4	-0.7	-1.1	-0.9
Major Depression (MDD)	0.5	0.6	2.1	0.9	1.4	-0.6	-1.1	-0.4	1.0	-0.7	0.3	-0.2	1.1	-0.1	-0.0	0.8
Verbal and Numeric Reasoning (VNR)	0.5	1.2	2.6	1.4	1.3	1.5	1.1	0.5	-0.6	1.2	1.6	1.1	0.2	1.3	0.5	1.0
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.8	0.0	-0.2	-0.7	-1.2	-1.3	0.0	-1.1	-0.9	-0.9	-0.3	-0.6	-0.8	-0.4
Blood White Count	0.5	3.4	11.9	0.5	0.2	-1.8	-3.5	-1.7	0.6	-2.4	-1.4	-1.9	-1.0	-2.3	-2.6	-0.9
Cardiovascular Disease	0.5	1.6	8.2	0.4	-0.7	-2.9	-2.5	-0.1	1.1	-1.6	0.7	-0.3	1.0	0.2	0.7	0.2
Number of treatments/medications taken	0.5	0.9	2.5	-1.6	-0.2	-1.1	-0.7	-1.0	1.1	-0.1	-0.5	-0.9	-1.0	-1.1	-1.0	-0.9
Medication for hormone replacement therapy	0.5	0.6	1.8	-0.8	-0.6	0.0	0.6	-1.2	-0.4	-0.4	0.9	-1.0	-0.7	-0.2	-0.5	-1.3
Vitamin and mineral supplements	0.5	0.6	2.2	1.1	0.6	-0.1	-0.9	0.1	-0.2	-0.6	-1.5	-1.2	-0.5	-0.9	-0.7	-0.1
Severe depression (siblings)	0.5	0.6	2.8	-0.1	1.7	-1.0	-0.1	-0.2	1.3	-0.1	-0.4	1.0	-0.1	-0.2	0.5	0.4
Pack years adult smoking proportion	0.5	0.8	2.0	0.1	-0.5	0.2	0.5	-1.3	-1.4	-1.3	-1.0	0.9	-0.9	0.8	-1.0	0.1
Average weekly fortified wine intake	0.5	0.6	1.5	-0.7	-0.5	-0.0	1.1	-1.1	0.1	0.8	-0.9	1.2	-1.0	0.3	-0.5	0.3
Multivitamins +/- minerals	0.5	0.6	2.3	-0.7	-1.0	-0.0	1.1	-0.3	-1.5	0.4	0.8	0.5	0.3	1.1	0.5	-0.3
Forced vital capacity (FVC)	0.5	2.0	6.3	1.5	-0.7	1.2	2.0	-0.2	-2.2	1.2	2.5	2.1	-0.6	0.8	0.2	0.4
Pain all over the body in last month	0.5	0.5	2.7	0.5	0.5	1.6	1.4	0.4	-0.2	-0.6	-0.3	0.2	-0.5	0.2	-0.8	-0.2
Arm fat percentage (right)	0.5	2.0	10.0	0.6	0.5	1.4	2.4	-1.5	-1.4	0.8	0.2	1.2	0.6	3.2	0.6	0.5
Tense / ‘highly strung’	0.5	0.8	4.7	-0.0	1.8	-0.2	-0.8	0.7	2.2	-0.2	-0.5	0.5	0.6	-0.2	0.6	0.7
Medication: Amlodipine	0.5	0.8	2.3	0.8	-0.5	0.1	-0.4	1.0	1.5	-0.7	0.1	0.6	1.4	0.4	0.7	1.5
Medication for pain relief, constipation, heartburn	0.5	0.9	2.8	1.7	0.3	-1.0	-1.4	-1.3	-1.2	-0.8	1.1	-0.1	0.4	1.0	0.2	0.3
Mean time to correctly identify matches	0.5	0.9	3.4	0.2	1.9	-1.0	-1.2	-1.6	0.7	-0.2	-1.0	-0.2	0.4	-0.9	-0.3	1.0
Alcohol intake frequency.	0.5	1.1	3.1	1.8	1.3	1.3	-0.1	0.2	-1.1	-1.3	1.1	0.3	1.1	0.4	0.0	1.3
Had major operations	0.5	0.5	1.9	-0.8	-0.9	-0.3	-0.7	1.4	1.1	0.1	-0.1	-1.0	0.1	-0.9	0.1	-0.1
Illnesses of siblings: Diabetes	0.5	0.7	4.0	-0.3	-0.3	0.6	-0.2	-0.8	-2.0	0.1	0.1	-0.1	-1.5	0.2	-0.7	-0.6
Arm fat percentage (left)	0.5	2.0	10.9	0.6	0.2	1.0	2.1	-1.8	-1.9	0.3	0.1	1.2	0.3	3.3	0.4	0.4
Mouth/teeth dental problems: Mouth ulcers	0.5	0.8	2.9	-1.6	-0.8	-0.0	-0.4	-0.1	0.4	-0.4	0.3	-1.2	-0.5	-1.2	-0.4	-1.7
Mineral and other dietary supplements	0.5	0.7	4.0	1.2	0.7	0.6	-0.4	0.1	-0.0	-2.0	-0.8	-0.7	0.2	-0.7	-0.7	0.2
Supplements: Fish oil (including cod liver oil)	0.5	0.7	2.3	-0.6	0.1	-0.3	0.6	-0.5	0.2	1.3	0.7	1.5	0.1	1.5	0.8	0.6
Leg fat percentage (left)	0.5	2.0	4.6	-0.9	-0.5	-1.7	-1.0	-2.1	-0.1	-0.7	-1.7	-1.5	-1.8	-0.7	-1.8	-2.0
Cholesterol lowering medication	0.5	0.7	3.4	0.0	0.2	-0.3	-1.1	1.3	1.8	-0.1	1.0	-0.1	1.0	-0.3	0.8	0.7
Ovarian Cancer	0.4	0.6	1.7	-0.7	0.6	-1.1	-0.3	-0.3	-0.3	1.3	-0.7	-1.3	0.2	-0.9	0.0	-0.6
Body Mass Index (BMI) (2010)	0.4	0.5	2.2	0.8	-1.0	0.7	1.5	0.4	0.0	0.7	1.3	-0.1	0.2	0.6	0.4	-0.1
Heel T-Score	0.4	3.5	14.9	2.2	1.0	-2.5	0.2	-2.4	0.7	1.6	3.9	1.2	1.2	0.6	1.8	1.6
Type 2 Diabetes (T2D) (2018)	0.4	0.7	4.7	0.2	0.1	-0.3	-1.2	0.5	2.2	0.1	-1.3	-0.3	0.5	-0.4	0.1	0.5
Angina	0.4	0.5	2.3	0.6	-1.5	-0.0	-0.2	-0.2	1.0	-1.2	0.3	0.2	-0.5	-0.8	-0.7	0.3
Medication: Atenolol	0.4	0.5	2.1	1.0	-0.3	-0.7	-0.0	-1.1	1.4	-0.1	1.1	0.5	0.5	0.0	0.5	0.6
Heart attack	0.4	0.5	1.4	1.2	-0.1	-0.6	-0.7	-0.8	-0.0	-1.0	0.9	0.6	0.1	0.1	-0.6	1.0
Prospective memory result	0.4	0.4	1.8	-0.7	-0.4	0.0	0.8	-0.9	-1.4	-0.2	0.4	0.9	-0.4	0.6	0.3	-0.3
Exposure to tobacco smoke at home	0.4	0.5	2.1	-1.1	-0.4	1.4	0.7	0.7	-0.5	0.6	-0.6	0.1	-0.4	0.3	-0.1	-0.7
Seen doctor (GP) for nerves, anxiety, tension or depression	0.4	0.6	3.8	0.9	0.9	-0.4	-0.5	0.0	-0.2	0.2	1.9	0.8	0.4	0.2	0.7	0.2
Forced vital capacity (FVC), Best measure	0.4	1.6	4.2	1.4	-1.3	0.9	1.7	0.5	-2.0	0.9	2.0	1.8	0.1	0.8	0.5	0.4
Health satisfaction	0.4	0.5	2.7	-0.9	0.1	1.2	1.6	0.7	0.6	0.1	0.2	0.4	-0.3	-0.3	-0.4	0.2
Angina (self-reported)	0.4	0.5	1.6	0.6	-1.3	0.2	-0.1	-0.1	0.9	-1.1	0.5	0.0	-0.6	-1.0	-0.7	0.2
Illness, injury, bereavement, stress in last 2 years	0.4	0.5	1.9	-0.9	0.2	0.6	0.7	1.0	0.3	1.4	0.3	-0.2	0.9	0.3	0.7	-0.0
Hypertension (Self-reported)	0.4	1.0	5.4	-0.1	0.2	-2.3	-2.1	-0.8	0.4	-1.1	0.3	-0.3	0.6	-0.1	0.1	0.4
Average weekly red wine intake	0.4	0.5	1.4	-0.9	-0.8	-0.6	-0.4	0.6	1.2	-0.9	0.2	-0.9	0.9	-0.2	0.8	-0.2
Diabetes diagnosed by doctor	0.4	0.6	4.5	0.1	-0.2	-0.4	-0.9	0.1	2.1	-1.0	-0.9	-0.2	-0.2	-0.4	-0.4	0.1
Myopia	0.4	0.5	2.9	-1.1	1.0	-1.7	-0.7	-0.7	0.4	0.2	-0.5	0.2	-0.2	0.3	0.4	-0.1
Vascular/heart problems diagnosed by doctor	0.4	1.1	4.1	-1.0	0.3	2.0	1.7	0.8	-0.1	1.3	-0.7	-0.5	-0.9	-0.9	-0.4	-1.2
Supplements: Calcium	0.4	0.5	1.3	0.3	-0.2	-0.9	-1.0	0.5	0.9	-0.4	-0.3	-1.0	1.1	0.5	0.5	-0.3
Reaction Time	0.3	0.6	1.8	0.5	0.9	-0.8	-1.0	-1.1	0.3	0.5	-0.1	0.2	1.4	0.0	0.8	1.3
Medication: Metformin	0.3	0.5	3.8	0.2	-0.7	-0.1	-0.4	0.9	1.9	0.1	-0.5	0.0	0.5	-0.0	0.4	0.5
Trunk fat percentage	0.3	1.3	8.6	0.4	0.6	0.2	1.4	-1.9	-0.2	0.4	-0.9	1.0	0.4	2.9	0.4	0.4
Serious illness, injury or assault to yourself	0.3	0.4	1.6	0.1	-0.3	-0.3	-0.6	0.5	0.6	-0.2	0.4	-0.1	0.9	1.3	1.0	0.7
High blood pressure	0.3	0.7	3.1	0.2	0.2	-1.8	-1.6	-0.5	0.3	-0.9	0.8	0.2	0.9	0.6	0.5	0.8
Diverticular disease/diverticulitis (self-reported)	0.3	0.4	1.7	0.1	0.1	1.0	0.4	-0.2	0.4	0.6	-0.4	-1.1	0.6	-1.3	-0.1	-0.2
Financial difficulties in last 2 years	0.3	0.4	1.8	0.6	0.7	0.3	-0.0	0.5	0.1	0.2	0.4	-0.8	-0.2	-1.4	-0.5	-0.7
Medication: Simvastatin	0.3	0.4	1.5	1.2	-0.3	-0.7	-0.2	0.2	0.9	-0.3	0.7	0.9	0.4	0.0	0.1	0.9
Pulse rate	0.3	0.5	1.2	-1.1	0.7	-0.0	0.3	0.3	0.5	1.1	-0.9	-0.3	-0.8	0.3	-0.4	-1.0
Exposure to tobacco smoke outside home	0.3	0.5	2.0	-0.6	0.1	0.1	-0.5	1.4	0.6	0.9	1.3	-0.3	0.1	-0.5	0.5	-0.1
Medication: Bendroflumethiazide	0.3	0.5	1.9	0.3	0.5	-0.4	-1.0	0.1	0.7	0.3	0.2	0.6	0.6	1.0	0.5	1.4
Fractured/broken bones in last 5 years	0.3	0.4	1.7	0.9	1.3	-0.3	-1.0	-1.0	0.1	-0.1	-0.5	0.1	-0.2	-0.2	-0.6	0.6
Heart attack/myocardial infarction (self-reported)	0.3	0.4	1.0	1.0	-0.2	-0.6	-0.6	-0.9	-0.2	-0.9	0.9	0.4	-0.2	-0.0	-0.8	0.7
Alzheimer’s Disease (including proxy)	0.2	0.4	2.3	-0.5	-0.3	0.0	0.1	0.0	-1.0	-0.3	0.6	0.5	0.0	1.5	0.3	-0.3
Chronotype (morning person)	0.2	0.5	2.7	-0.4	0.1	-0.3	-0.5	0.8	-0.4	-0.7	-0.2	-1.6	-0.2	-0.6	-0.3	-1.2
Systolic blood pressure, automated reading	0.2	0.7	2.9	0.5	-1.1	-0.5	0.2	-0.5	0.7	1.4	1.7	0.3	0.5	0.4	0.8	0.4
Medication: Co-codamol	0.2	0.2	1.1	0.1	-0.1	0.6	0.5	-0.4	-0.2	1.0	0.6	0.2	-0.1	-0.0	-0.4	0.0
Ever unenthusiastic/disinterested for a whole week	0.2	0.2	1.1	-0.5	0.9	0.3	-0.1	0.3	1.0	-0.3	0.2	0.4	-0.0	-0.4	-0.0	-0.0
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.2	0.8	0.4	-0.3	-0.4	-0.7	0.5	0.2	-0.9	-0.0	0.8	0.2	0.1	0.4	0.4
Depression (self-reported)	0.2	0.3	1.4	0.1	1.2	-0.4	-0.7	-0.4	0.7	-0.3	0.8	-0.0	0.1	0.4	0.1	0.1
High blood pressure (siblings)	0.2	0.3	1.2	-0.7	0.3	0.4	0.4	-1.1	-0.1	1.0	-0.2	-0.0	-0.0	-0.3	-0.1	-0.0
Body fat percentage	0.2	0.7	3.8	0.1	0.3	-0.2	0.9	-1.7	0.1	0.4	-1.0	0.3	0.1	2.0	0.1	-0.2
Osteoporosis (self-reported)	0.2	0.2	0.9	1.0	0.2	0.4	-0.5	0.4	0.0	-0.4	-0.2	0.3	0.2	0.7	-0.1	0.6
Alcohol drinker status: Never	0.2	0.3	1.9	-0.3	0.2	1.0	0.2	0.5	0.3	-0.0	1.4	0.3	0.1	0.0	0.3	0.4
Bipolar Disorder (2011)	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0

Hub : Genes

ADAM15

Models

Trait associations