Best TWAS P=9.8e-16 · Best GWAS P=6.08e-18 conditioned to 0.00136
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | YFS | Blood | SUPV3L1 | 0.05 | 0.04 | blup | 531 | 0.05 | 1.2e-15 | 3.5 | -5.1 | 3.1e-07 | 0.61 | 1.00 | 0.00 | FALSE |
| 2 | The Cancer Genome Atlas | Breast Invasive Carcinoma | HKDC1 | 0.02 | 0.02 | enet | 9 | 0.02 | 3.9e-05 | -8.6 | -8.0 | 9.8e-16 | 0.91 | 0.00 | 1.00 | TRUE |
| 3 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | HKDC1 | 0.06 | 0.02 | blup | 77 | 0.04 | 3.0e-05 | -7.4 | -7.2 | 4.9e-13 | 0.76 | 0.00 | 0.99 | FALSE |
| 4 | The Cancer Genome Atlas | Lung Adenocarcinoma | HKDC1 | 0.04 | 0.02 | blup | 76 | 0.01 | 1.2e-02 | 4.7 | -5.7 | 1.4e-08 | 0.59 | 0.02 | 0.83 | FALSE |
| 5 | The Cancer Genome Atlas | Pancreatic Adenocarcinoma | HKDC1 | 0.17 | 0.04 | lasso | 5 | 0.07 | 6.0e-04 | -6.9 | -6.9 | 4.6e-12 | 0.82 | 0.07 | 0.49 | FALSE |
| 6 | The Cancer Genome Atlas | Thyroid Carcinoma | HKDC1 | 0.14 | 0.11 | lasso | 6 | 0.14 | 8.2e-14 | -3.7 | -7.4 | 1.8e-13 | 0.76 | 0.02 | 0.98 | FALSE |
| 7 | The Cancer Genome Atlas | Thyroid Carcinoma | SUPV3L1 | 0.03 | 0.01 | blup | 60 | 0.02 | 6.3e-03 | -7.1 | -6.7 | 2.0e-11 | 0.77 | 0.00 | 0.85 | FALSE |