TWAS hub - SUPV3L1

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Adipose Subcutaneous	0.0880	0.0350	7.2e-03	0.010	NA	0.012	NA	0.022	4.5e-02	NA	3.2e-02	NA	5.9e-03
2	METSIM	Adipose	0.0363	0.0140	2.5e-03	0.007	0.026	0.019	0.022	0.015	2.7e-02	8.3e-05	5.4e-04	2.1e-04	1.8e-03
3	YFS	Blood	0.0529	0.0115	7.3e-14	0.039	0.049	0.045	0.046	0.045	9.9e-13	1.2e-15	1.4e-14	8.1e-15	1.4e-14
4	TCGA	Esophageal Carcinoma	0.2800	0.1050	1.6e-03	0.023	0.114	0.023	NA	0.035	6.4e-02	1.9e-04	6.0e-02	NA	2.9e-02
5	TCGA	Thyroid Carcinoma	0.0310	0.0160	8.1e-03	0.013	0.018	0.003	NA	0.008	1.9e-02	6.3e-03	1.4e-01	NA	4.9e-02

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5
Birth weight	9.7	21.0	45.0	0.3	-4.3	-5.1	-4.0	-6.7
Birth weight of first child	7.7	14.0	31.3	0.9	-4.0	-4.5	-1.4	-5.6
Comparative body size at age 10	5.1	14.2	30.7	-0.4	-3.3	-4.4	-3.2	-5.5
Illnesses of father: None of the above (group 1)	5.0	6.2	12.2	-1.1	2.7	1.9	3.5	2.5
Ever highly irritable/argumentative for 2 days	4.7	5.6	11.7	-0.4	2.1	3.4	1.7	3.0
Chronotype (morning person)	3.7	8.6	16.5	1.5	-3.7	-4.1	-0.8	-3.1
Major Depression (MDD)	3.3	4.0	6.5	-0.1	-2.1	-2.3	-2.1	-2.6
Illnesses of father: Heart disease	3.3	4.6	6.2	1.2	-2.3	-2.4	-2.2	-2.5
Age started oral contraceptive pill	3.0	3.7	5.8	1.2	-2.4	-1.5	-2.0	-2.2
Fasting Glucose	2.9	3.5	6.3	-0.3	2.4	2.2	0.6	2.5
Serious illness, injury or assault to yourself	2.8	3.4	5.3	2.1	1.2	2.3	1.6	1.8
Alzheimer’s Disease (in father)	2.7	2.9	4.5	-0.4	-1.4	-2.1	-2.1	-1.9
Eye problems/disorders: None of the above	2.6	3.0	6.7	2.6	1.6	1.6	-0.2	1.8
Hearing aid user	2.6	2.9	5.8	0.1	-2.4	-2.1	-0.7	-1.9
Age at last live birth	2.4	3.4	7.7	-0.5	1.0	1.6	2.8	2.4
Illnesses of mother	2.3	2.9	4.2	-0.1	1.9	1.8	1.8	2.0
Financial situation satisfaction	2.3	2.9	5.6	-0.2	1.3	1.8	2.4	1.9
Medication for hormone replacement therapy	2.2	2.5	4.3	-0.6	2.1	2.0	1.0	1.6
Diabetes (mother)	2.2	2.7	3.7	1.7	-1.6	-1.1	-1.8	-1.9
Neck or shoulder pain in last month	2.2	3.2	6.3	-2.5	-1.0	-1.6	-0.9	-2.3
Supplements: Vitamin C	2.2	2.6	3.6	-1.2	-1.9	-1.9	-1.2	-1.8
Alcohol drinker status: Never	2.2	2.6	4.6	1.8	-1.1	-1.7	-1.1	-2.2
Alcohol intake versus 10 years previously	2.1	3.2	5.9	0.8	1.9	2.2	0.9	2.4
Medication: Ventolin 100micrograms inhaler	2.1	2.6	4.8	0.0	-2.2	-2.1	-0.0	-2.0
Reaction Time	2.0	3.8	4.8	1.8	-1.9	-1.9	-2.0	-2.2
Mean Putamen Volume	2.0	2.3	6.6	-2.6	1.1	1.7	-0.5	0.7
Chronic bronchitis/emphysema (mother)	1.9	2.2	4.3	0.3	-1.3	-1.7	-2.1	-1.5
Wheeze or whistling in the chest in last year	1.9	3.3	3.6	-1.8	-1.8	-1.9	-1.8	-1.9
Supplements: Fish oil (including cod liver oil)	1.9	2.4	7.5	0.4	-1.1	-1.3	-2.7	-1.2
Alzheimer’s Disease (including proxy)	1.8	2.6	5.8	-0.6	-1.3	-1.6	-2.4	-1.6
Allergy or Eczema	1.8	4.7	9.5	-1.0	-1.9	-3.1	-1.8	-2.5
Mouth/teeth dental problems: Dentures	1.8	3.0	3.6	-1.3	1.9	1.8	1.7	1.8
Supplements: Zinc	1.7	1.8	3.8	-1.9	-1.3	-1.2	-0.6	-1.4
Hayfever, allergic rhinitis or eczema	1.7	3.6	6.0	-0.6	-1.7	-2.4	-2.0	-2.1
Allergy	1.7	3.8	4.8	1.2	2.0	2.2	2.2	2.0
Blood White Count	1.6	12.0	21.0	-0.1	3.3	3.8	3.6	4.6
Lung FVC	1.6	8.3	22.5	1.0	2.2	2.5	2.7	4.7
Prospective memory result	1.6	1.9	3.3	-1.5	-1.8	-0.4	-1.8	-0.9
Mean time to correctly identify matches	1.6	3.0	4.0	2.0	-1.6	-1.5	-1.6	-1.9
Asthma (self-reported)	1.6	3.2	5.3	-1.4	-2.3	-1.6	-1.8	-1.7
Hearing difficulty/problems: Yes	1.5	2.3	3.5	-0.2	-1.6	-1.9	-1.5	-1.7
Alcohol usually taken with meals	1.5	2.5	5.1	-0.3	-1.8	-2.3	-0.4	-1.9
Smoking status: Current	1.5	2.4	7.8	-0.1	2.8	1.4	-0.1	1.5
Ovarian Cancer	1.4	1.8	3.7	-1.9	-1.8	-0.8	-0.3	-1.1
Blood Platelet Count	1.4	16.1	30.9	-2.0	3.4	3.7	4.5	5.6
Eye problems/disorders: Diabetes related eye disease	1.4	1.6	2.5	-1.1	-1.0	-1.3	-1.1	-1.6
Falls in the last year	1.4	1.9	3.2	0.1	1.7	1.8	0.9	1.6
Heart disease (mother)	1.4	1.7	3.5	1.5	-1.9	-1.0	-0.9	-1.1
Eye problems/disorders: Glaucoma	1.4	1.7	3.1	-0.5	-1.7	-1.2	-0.9	-1.8
Supplements: Calcium	1.4	1.5	2.6	-1.1	-1.6	-1.2	-1.0	-1.2
Coronary Artery Disease (CAD)	1.3	1.6	2.6	-1.6	-1.6	-1.1	-0.4	-1.2
Lupus	1.3	1.9	2.6	1.2	1.3	1.3	1.6	1.5
Ever used hormone-replacement therapy (HRT)	1.3	1.7	3.2	1.6	1.8	1.4	-0.4	0.7
Hearing difficulty/problems with background noise	1.3	2.1	3.8	-2.0	-1.2	-1.4	-1.6	-1.1
Time employed in main current job	1.3	1.5	6.6	2.6	-0.1	0.3	0.8	0.1
Angina (self-reported)	1.3	1.7	8.2	2.9	0.0	-0.4	0.0	0.2
Medication: Gliclazide	1.3	1.5	5.5	-0.2	2.3	1.3	-0.0	0.6
Current tobacco smoking	1.2	2.0	6.9	-0.1	2.6	1.3	-0.1	1.2
Hair/balding pattern: Pattern 2	1.2	1.6	4.1	0.7	1.1	0.6	2.0	1.3
Mouth/teeth dental problems	1.2	1.9	5.7	2.4	-0.7	-1.4	-0.5	-1.1
Father’s age at death	1.2	1.7	3.9	-0.8	-2.0	-0.9	-1.7	-0.3
Asthma	1.2	2.5	4.4	-1.5	-2.1	-1.2	-1.6	-1.3
Blood clot in the leg (DVT)	1.2	1.6	2.9	-1.7	1.4	0.8	0.7	1.4
Mouth/teeth dental problems: Loose teeth	1.2	1.5	2.9	0.0	0.9	1.4	1.3	1.7
Family relationship satisfaction	1.2	1.5	5.1	0.8	-2.3	-0.7	-1.0	-0.4
Osteoarthritis (self-reported)	1.2	1.5	2.2	0.1	1.3	1.3	1.5	1.4
Unable to work because of sickness or disability	1.2	1.6	3.6	-0.8	1.4	1.0	1.9	1.0
Respiratory disease	1.1	2.4	3.8	-1.6	-1.9	-1.4	-1.0	-1.7
Relative age of first facial hair	1.1	2.3	3.9	1.5	1.2	1.9	0.6	2.0
Townsend deprivation index at recruitment	1.1	1.5	2.9	-1.7	0.9	1.6	-0.0	1.0
Past tobacco smoking	1.1	2.1	3.9	1.9	2.0	1.0	1.2	0.7
Medication: Lansoprazole	1.1	1.2	2.3	1.2	0.2	0.9	1.5	1.2
Impedance of arm (left)	1.1	5.2	8.6	-1.7	2.2	2.1	2.2	2.9
Comparative height size at age 10	1.1	6.1	19.8	1.6	-1.6	-1.8	-1.6	-4.5
Medication: Aspirin	1.1	1.5	2.7	1.6	-1.1	-1.4	-0.5	-1.1
Smoking status: Previous	1.1	1.7	4.0	-1.9	-2.0	-0.4	-0.6	-0.2
Average weekly champagne plus white wine intake	1.1	1.5	2.6	1.4	0.2	-1.6	-0.8	-1.5
Average weekly beer plus cider intake	1.1	1.6	3.2	1.8	0.9	1.0	-0.5	1.7
Deep venous thrombosis (DVT) (self-reported)	1.1	1.5	2.7	-1.7	1.4	0.8	0.4	1.3
Hypothyroidism (self reported)	1.0	2.2	3.1	-1.1	1.7	1.8	1.0	1.7
Angina	1.0	1.4	6.5	2.5	0.2	-0.2	0.3	0.4
Diverticular disease/diverticulitis (self-reported)	1.0	1.2	2.5	-0.4	1.2	1.6	1.2	0.4
Medication: Simvastatin	1.0	1.4	5.4	2.3	-0.8	-0.9	-0.2	-0.5
Pulse wave reflection index	1.0	1.2	3.8	-1.2	-0.9	-0.1	-2.0	-0.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	1.0	1.1	5.2	-2.3	0.3	-0.4	0.4	0.4
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.0	1.1	2.5	1.6	-0.7	-0.9	-1.1	-0.9
Mother’s age at death	1.0	1.2	2.4	1.1	-0.7	-0.6	-1.2	-1.5
High cholesterol (Self-reported)	1.0	1.8	6.0	2.4	1.1	0.0	1.0	0.8
Fractured/broken bones in last 5 years	1.0	1.3	4.6	2.1	-0.9	-0.4	-0.8	-0.6
Systolic Blood Pressure	0.9	4.7	8.2	-1.2	1.8	2.4	2.1	2.9
Diabetes (father)	0.9	1.1	2.6	-1.6	-0.8	-0.7	-1.0	-0.8
Impedance of leg (right)	0.9	4.5	8.2	-1.4	2.0	1.9	2.2	2.9
Trunk fat percentage	0.9	3.5	7.2	0.8	2.7	2.2	1.7	1.3
Heel bone mineral density (BMD) T-score, automated (right)	0.9	2.0	4.3	2.1	0.8	-1.0	-2.0	-0.4
Hayfever/allergic rhinitis (self-reported)	0.9	1.2	2.4	-0.2	-1.6	-1.5	-0.1	-1.1
Hair/balding pattern: Pattern 3	0.9	1.3	2.6	-1.5	-1.1	-0.5	-1.6	-0.4
Medication: Cholesterol lowering	0.9	1.4	4.3	2.1	0.1	-1.1	-0.3	-1.2
Headache pain in last month	0.9	1.5	3.3	-1.8	-1.2	-1.2	0.6	-1.1
Leg fat percentage (right)	0.9	3.4	6.8	0.4	2.6	2.1	1.7	1.6
Alcohol intake frequency.	0.9	2.1	3.9	-0.3	-1.6	-1.3	-2.0	-1.5
Number of full sisters	0.9	1.1	2.2	-1.5	-1.4	-0.8	-0.5	-0.6
Commuting to job workplace: Car/motor vehicle	0.9	1.0	3.8	2.0	1.0	0.4	0.2	0.4
Eye problems/disorders: Cataract	0.9	1.0	2.7	-1.6	0.2	0.7	1.2	0.4
Back pain experienced in last month	0.9	1.3	3.1	-0.9	1.5	1.8	0.3	0.8
Mineral and other dietary supplements	0.9	1.2	4.4	0.3	0.5	1.0	2.1	0.3
Wears glasses or contact lenses	0.9	1.1	2.0	0.8	-0.6	-0.6	-1.4	-1.4
Ever taken oral contraceptive pill	0.9	1.0	1.7	-0.9	-1.0	-1.1	-0.3	-1.3
Cholesterol lowering medication	0.9	1.3	5.6	2.4	-0.1	0.3	0.7	0.5
Blood Eosinophil Count	0.8	5.9	16.6	-1.4	-4.1	-2.5	-1.5	-1.4
Tinnitus: Yes, but not now, but have in the past	0.8	0.8	3.6	-1.9	0.3	0.1	0.7	-0.2
Stomach or abdominal pain in last month	0.8	1.0	2.0	-1.4	0.2	1.2	1.1	0.8
Impedance of leg (left)	0.8	3.7	7.5	-1.5	1.7	1.6	1.8	2.7
Number of incorrect matches in round	0.8	1.4	5.2	-2.3	-0.4	-0.1	-0.8	-0.9
Financial difficulties in last 2 years	0.8	1.1	2.4	0.1	1.6	1.2	0.9	0.9
Exposure to tobacco smoke at home	0.8	1.0	2.0	1.2	-0.9	-0.1	-1.4	-0.7
Forced vital capacity (FVC), Best measure	0.8	3.0	4.0	1.9	1.7	1.6	1.3	2.0
Body fat percentage	0.8	3.1	6.5	0.6	2.5	2.1	1.6	1.3
Medication: Ibuprofen	0.8	0.9	2.4	-0.9	0.5	0.8	-0.6	1.6
Chest pain or discomfort	0.8	1.2	2.4	-0.6	-1.4	-1.0	-0.4	-1.6
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.8	1.7	3.6	0.6	0.7	1.3	1.5	1.9
Medication: Paracetamol	0.8	1.2	3.2	-1.8	-0.0	0.6	1.4	0.7
Leg fat percentage (left)	0.8	2.7	5.8	0.2	2.4	1.9	1.4	1.5
Risk taking	0.8	1.1	3.3	0.3	1.8	1.2	0.1	0.9
Impedance of whole body	0.8	4.3	7.2	-1.8	1.9	1.8	2.1	2.7
Verbal and Numeric Reasoning (VNR)	0.7	1.7	7.9	2.8	-0.4	-0.5	0.5	-0.3
Crohns Disease (2012)	0.7	1.2	2.9	0.5	0.4	1.7	0.7	1.5
Triglycerides	0.7	1.2	2.8	-0.7	1.1	1.2	0.2	1.7
Other serious medical condition/disability diagnosed by doctor	0.7	0.9	2.9	1.7	0.7	0.8	-0.5	0.4
Frequency of tenseness / restlessness in last 2 weeks	0.7	1.1	3.3	-1.8	0.7	1.1	-0.1	0.7
Pain all over the body in last month	0.7	0.8	2.1	-0.1	0.6	1.4	0.2	1.2
Fluid intelligence score	0.7	1.4	5.1	2.3	-0.4	-1.1	0.3	-0.5
Impedance of arm (right)	0.7	3.4	5.0	-1.9	1.8	1.6	1.7	2.2
Hip circumference	0.7	2.8	7.8	1.0	2.8	1.9	0.9	0.8
Serious illness, injury or assault of a close relative in last 2 years	0.7	0.8	1.5	0.1	-0.8	-1.2	-0.7	-1.0
Depression (self-reported)	0.7	0.9	1.7	1.1	-1.3	-0.8	-0.8	-0.6
Arm fat-free mass (right)	0.7	3.4	6.8	2.5	-0.2	-0.7	-1.8	-2.6
Had major operations	0.7	0.8	2.8	0.3	-0.3	0.9	1.7	0.6
Illness, injury, bereavement, stress in last 2 years	0.7	0.8	1.6	-0.0	-1.3	-1.3	-0.0	-1.0
Arm fat percentage (left)	0.7	2.7	5.9	0.6	2.4	1.9	1.4	1.4
Mood swings	0.7	1.4	3.3	-1.2	0.3	1.8	0.1	1.4
Diabetes diagnosed by doctor	0.7	1.2	2.8	0.9	-0.6	-0.8	-1.2	-1.7
Medication: Aspirin	0.7	1.0	4.2	2.1	-0.5	-0.4	-0.1	-0.4
Arm fat-free mass (left)	0.7	3.7	8.0	2.8	-0.1	-0.6	-1.8	-2.7
Arm predicted mass (left)	0.7	3.5	7.1	2.7	-0.1	-0.8	-1.7	-2.6
Schizophrenia (2018)	0.6	1.3	2.5	1.0	-0.2	-1.6	-0.9	-1.5
Schizophrenia vs Biploar Disorder	0.6	0.8	2.1	1.4	-0.2	-0.1	-1.0	-0.9
Smoking Status	0.6	1.3	4.2	-2.0	0.5	0.8	-1.0	0.8
Systolic blood pressure, automated reading	0.6	1.7	4.3	-0.1	1.0	1.5	2.1	1.0
Maternal smoking around birth	0.6	0.8	2.4	-1.5	0.5	0.3	0.9	0.8
High blood pressure (mother)	0.6	0.8	2.0	-0.7	-1.4	-1.0	-0.5	-0.7
Waist circumference	0.6	2.1	4.0	0.7	1.8	2.0	1.1	1.1
Arm fat percentage (right)	0.6	2.2	5.3	0.5	2.3	1.6	1.1	1.1
Trunk fat-free mass	0.6	3.6	7.2	2.5	-0.1	-0.8	-1.9	-2.7
Forced expiratory volume in 1-second (FEV1), Best measure	0.6	1.9	3.3	1.8	1.4	0.9	1.1	1.4
Trunk predicted mass	0.6	3.6	7.1	2.6	-0.1	-0.9	-1.9	-2.7
Tense / ‘highly strung’	0.6	0.9	1.4	-0.1	-1.2	-1.0	-1.1	-1.0
Seen doctor (GP) for nerves, anxiety, tension or depression	0.6	0.9	2.1	-0.5	0.5	1.4	-0.1	1.4
Peak expiratory flow (PEF)	0.6	1.3	2.2	-0.1	1.5	0.8	1.4	1.3
Worry too long after embarrassment	0.6	1.1	3.0	0.9	-0.5	-0.9	-1.7	-0.7
Qualifications: College or University degree	0.6	2.0	3.4	1.0	-1.6	-1.8	0.0	-1.7
Arm predicted mass (right)	0.6	3.3	6.8	2.6	-0.1	-0.6	-1.8	-2.4
Knee pain experienced in last month	0.6	0.9	2.5	-1.6	1.2	0.6	0.1	0.2
Whole body fat-free mass	0.6	3.6	7.2	2.7	-0.0	-0.7	-1.9	-2.6
Qualifications: nursing, teaching	0.6	0.9	1.5	1.2	-0.9	-1.2	-0.1	-1.0
Whole body water mass	0.6	3.6	7.2	2.7	-0.1	-0.7	-1.9	-2.6
Miserableness	0.6	1.0	3.1	-0.4	0.8	1.8	0.1	1.2
Guilty feelings	0.6	0.9	1.4	-0.9	-0.9	-1.1	-0.4	-1.2
Pack years of smoking	0.6	0.9	1.6	0.9	0.4	1.3	1.1	0.7
Prostate Cancer	0.5	0.7	2.2	0.7	0.1	-0.6	0.5	-1.5
Type 2 Diabetes (T2D) (2018)	0.5	1.0	2.1	0.1	-0.8	-0.9	-1.4	-1.2
Ever had hysterectomy (womb removed)	0.5	0.5	1.4	0.4	-0.4	-0.6	-1.2	-0.7
Vitamin and mineral supplements	0.5	0.6	1.0	0.9	1.0	0.8	0.4	0.8
Pack years adult smoking proportion	0.5	0.8	1.7	0.8	0.5	1.3	1.0	0.7
Heel bone mineral density (BMD) T-score, automated (left)	0.5	1.1	2.5	0.3	0.1	-1.5	-1.6	-0.7
Trunk fat mass	0.5	2.2	5.2	1.3	2.3	1.8	0.9	0.4
Had other major operations	0.5	0.6	1.2	-0.4	0.5	0.7	1.0	1.1
Forced vital capacity (FVC)	0.5	2.1	3.1	1.7	1.4	1.5	0.6	1.8
Pulse rate	0.5	0.8	3.1	-0.5	0.4	0.6	1.8	-0.0
Mouth/teeth dental problems: Bleeding gums	0.5	0.7	1.4	-0.3	-1.2	-0.7	-0.5	-1.0
Medication: Paracetamol	0.5	0.8	2.7	-1.6	-0.2	0.5	1.0	0.5
Medication for cholesterol, blood pressure or diabetes	0.5	0.9	3.6	-1.9	0.3	0.7	0.3	0.5
Glaucoma (self-reported)	0.5	0.6	1.5	-0.4	-1.2	-0.6	-0.5	-0.9
Overall health rating	0.5	1.1	1.8	-1.2	0.8	1.3	-0.7	1.0
Illnesses of siblings: Diabetes	0.5	0.7	1.4	-1.0	-0.8	0.0	-1.2	-0.5
Leg fat-free mass (right)	0.5	2.7	5.4	2.3	-0.0	-0.5	-1.6	-2.3
Ever had bowel cancer screening	0.5	0.5	1.2	0.6	0.1	1.1	0.5	0.9
Friendships satisfaction	0.5	0.6	0.8	0.9	0.5	0.8	0.9	0.9
Medication for cholesterol	0.5	0.7	1.4	-1.2	-0.5	-1.0	-0.6	-0.9
Leg predicted mass (right)	0.5	2.6	5.6	2.4	-0.0	-0.5	-1.5	-2.2
Medication: Atorvastatin	0.5	0.6	1.0	0.2	0.9	0.6	0.9	1.0
Basal metabolic rate	0.5	2.7	6.8	2.6	0.4	-0.3	-1.3	-2.2
Myopia	0.5	0.7	2.0	1.4	-1.1	-0.4	-0.5	0.3
Basal cell carcinoma (self-reported)	0.5	0.6	1.5	-0.3	-0.4	-1.2	0.4	-0.9
Bipolar Disorder or Schizophrenia	0.4	1.0	1.7	1.2	-0.2	-1.3	-1.1	-0.9
Bipolar Disorder (2011)	0.4	0.4	0.8	-0.5	0.7	0.5	0.9	0.0
Body Mass Index (BMI) (2010)	0.4	0.5	2.1	1.5	0.0	0.2	0.7	-0.1
Schizophrenia (2014)	0.4	0.9	1.6	1.3	0.1	-1.1	-0.7	-1.1
Ulcerative Colitis	0.4	0.5	2.0	-1.4	-0.7	-0.1	0.4	0.2
Medication: Metformin	0.4	0.5	1.2	1.0	1.1	0.3	-0.4	-0.5
Leg fat-free mass (left)	0.4	2.3	5.7	2.4	0.4	-0.1	-1.3	-2.0
Hand grip strength (right)	0.4	1.0	3.0	0.6	1.7	0.8	0.8	0.5
Bilateral oophorectomy (both ovaries removed)	0.4	0.5	1.8	-0.2	0.4	0.6	-1.3	-0.1
Supplements: Glucosamine	0.4	0.5	1.2	-0.2	-0.4	-0.9	-1.1	-0.5
Leg predicted mass (left)	0.4	2.2	5.3	2.3	0.4	-0.1	-1.3	-2.0
Ever unenthusiastic/disinterested for a whole week	0.4	0.5	1.0	0.3	-0.3	1.0	0.3	1.0
Heart attack	0.4	0.5	0.7	-0.9	0.6	0.7	0.7	0.5
Forced expiratory volume in 1-second (FEV1)	0.4	1.4	2.3	1.5	1.2	1.0	0.5	1.3
Qualifications: A levels/AS levels or equivalent	0.4	0.9	2.7	0.1	-0.9	-1.6	0.3	-0.9
Medication: Ibuprofen (e.g. Nurofen)	0.4	0.6	1.9	-0.3	0.1	0.5	-0.7	1.4
Lung cancer (father)	0.4	0.4	0.8	-0.9	-0.7	-0.3	0.3	-0.8
Pulse wave Arterial Stiffness index	0.4	0.5	1.7	-0.5	0.4	1.3	-0.5	-0.0
High blood pressure (siblings)	0.4	0.6	1.7	0.1	-1.3	-0.7	-0.1	-0.8
Age at first live birth	0.4	0.6	1.5	0.7	-0.8	-0.8	1.2	0.1
Pulse wave peak to peak time	0.4	0.5	1.6	0.7	-0.3	-1.3	0.6	0.0
Whole body fat mass	0.4	1.6	4.1	1.2	2.0	1.3	0.6	0.1
Leg fat mass (right)	0.4	1.7	4.4	1.1	2.1	1.5	0.8	0.6
Pulse rate, automated reading	0.4	1.4	3.7	-0.1	0.9	1.1	1.9	1.1
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.4	0.5	2.0	-0.3	0.4	-0.1	1.4	0.3
Commuting to job workplace: Walk	0.4	0.4	0.9	0.4	-0.8	-1.0	0.5	-0.3
Number of self-reported non-cancer illnesses	0.4	0.6	1.2	0.3	0.5	1.0	0.7	1.1
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.3	1.1	0.7	0.3	0.8	0.0
Illnesses of father: High blood pressure	0.4	0.5	1.3	0.8	-0.9	-0.0	-1.1	-0.1
Ever had prostate specific antigen (PSA) test	0.4	0.5	1.2	1.1	-0.0	0.1	1.1	-0.0
Ever depressed for a whole week	0.4	0.5	2.0	1.4	-0.4	-0.4	0.1	-0.1
Leg fat mass (left)	0.4	1.5	3.9	1.1	2.0	1.4	0.5	0.5
Depressed Affect (Nagel 2018)	0.3	0.6	1.8	-0.4	0.2	1.4	0.4	0.7
Worry (Nagel 2018)	0.3	0.6	1.6	0.7	-1.3	-0.4	-0.9	-0.3
Crohns Disease (2017)	0.3	0.6	1.2	0.4	0.3	1.1	0.8	0.9
Irritable Bowel Disease (IBD)	0.3	0.6	1.4	-0.1	0.1	1.0	0.9	1.2
Rheumatoid Arthritis	0.3	0.4	1.3	-1.1	-0.3	0.1	0.5	0.5
Height	0.3	5.8	16.3	4.0	2.8	0.7	-0.7	-1.9
Average weekly spirits intake	0.3	0.3	0.8	-0.6	0.6	0.9	0.2	0.1
Frequency of depressed mood in last 2 weeks	0.3	0.5	2.2	-1.5	0.1	-0.1	-0.2	-0.3
Medication: Co-codamol	0.3	0.3	0.7	0.3	-0.0	-0.5	-0.9	-0.6
Frequency of unenthusiasm / disinterest in last 2 weeks	0.3	0.4	1.0	-1.0	0.7	0.2	-0.4	-0.2
Taking other prescription medications	0.3	0.5	1.4	0.7	-0.5	0.4	-1.2	-0.0
Age when periods started (menarche)	0.3	0.8	2.6	1.6	-1.0	-0.2	0.4	0.1
High blood pressure	0.3	0.8	1.3	-1.1	-0.8	0.3	1.0	1.0
Nervous feelings	0.3	0.5	1.6	0.3	-0.9	-0.2	-1.3	-0.0
Qualifications: None of the above	0.3	0.6	2.1	-0.1	0.4	1.5	0.0	0.7
Medication: Ramipril	0.3	0.4	0.8	0.7	-0.9	0.2	0.8	0.4
Illnesses of siblings	0.3	0.4	0.9	0.6	0.8	0.1	0.3	0.9
Weight	0.3	1.6	4.4	2.1	1.2	0.3	-0.5	-1.3
Worrier / anxious feelings	0.3	0.5	1.1	0.6	-0.2	0.7	0.7	1.1
Frequency of tiredness / lethargy in last 2 weeks	0.3	0.5	0.8	-0.9	0.9	0.6	0.2	0.7
Happiness	0.3	0.4	1.9	-0.3	-1.4	-0.1	-0.2	-0.2
Arm fat mass (right)	0.3	1.1	2.8	1.3	1.7	1.0	0.4	0.1
Standing height	0.3	2.9	6.6	2.6	0.7	-0.2	-1.3	-2.3
Breastfed as a baby	0.3	0.3	1.0	-0.1	1.0	0.3	0.6	0.5
Qualifications: O levels/GCSEs or equivalent	0.3	0.4	0.9	0.2	1.0	0.2	0.8	0.7
Number of full brothers	0.3	0.3	0.7	-0.2	0.6	0.8	0.2	0.8
Number of children fathered	0.3	0.3	0.7	0.6	0.9	0.5	0.2	0.5
Emphysema/chronic bronchitis	0.3	0.3	0.7	-0.8	-0.1	-0.2	-0.5	-0.8
Qualifications: NVQ or HND or HNC or equivalent	0.3	0.4	1.1	-1.0	0.3	0.1	0.7	0.5
Hypertension (Self-reported)	0.3	0.9	1.4	-0.9	-0.6	0.6	1.2	1.2
Average weekly red wine intake	0.3	0.4	1.2	-1.1	0.3	-0.4	0.4	-0.7
Loneliness, isolation	0.3	0.4	1.0	-1.0	0.8	0.6	-0.1	0.2
Long-standing illness, disability or infirmity	0.3	0.5	1.1	0.1	0.1	1.0	0.5	1.1
Ever had stillbirth, spontaneous miscarriage or termination	0.3	0.3	0.6	-0.8	0.8	0.1	-0.4	0.5
Breast cancer (self-reported)	0.3	0.3	0.9	0.9	-0.6	-0.5	0.0	0.3
Osteoporosis (self-reported)	0.3	0.4	1.2	-0.2	-1.1	-0.1	-0.9	0.1
Arm fat mass (left)	0.3	1.2	2.7	1.4	1.6	0.9	0.4	-0.0
Tinnitus: Yes, now most or all of the time	0.3	0.4	1.4	0.5	0.3	0.2	-1.2	0.3
Medication: Lisinopril	0.3	0.4	1.5	-0.3	1.2	0.3	-0.1	0.6
Irritability	0.3	0.4	1.0	-0.9	0.0	1.0	-0.6	-0.1
Commuting to job workplace: Cycle	0.3	0.3	0.6	-0.7	-0.8	-0.6	0.1	-0.1
Pain experienced in last month	0.3	0.4	1.6	1.3	-0.6	-0.4	0.0	-0.2
Intelligence (Savage-Jansen 2018)	0.2	0.6	2.2	1.5	-0.5	-0.8	0.1	-0.1
Alzheimer’s Disease (in mother)	0.2	0.2	0.7	-0.5	0.1	0.2	-0.8	0.1
Ulcerative Colitis (UC)	0.2	0.3	0.7	-0.9	0.1	0.4	0.4	0.7
HDL Cholesterol	0.2	0.3	0.9	0.1	0.6	0.1	1.0	0.2
Primary Biliary Cirrhosis	0.2	0.3	1.1	-0.1	0.8	-0.1	-1.0	0.1
Type 2 Diabetes (T2D) (2012)	0.2	0.3	1.0	-1.0	0.2	-0.3	0.2	-0.6
Blood Red Count	0.2	1.8	6.1	0.3	-0.6	1.2	2.5	-0.9
BMI	0.2	1.1	4.2	2.0	-0.1	-0.6	-0.4	-0.9
Waist Hip Ratio (WHR)	0.2	0.9	2.1	-0.2	-1.0	1.0	0.7	1.4
Cardiovascular Disease	0.2	0.8	2.5	0.1	0.0	0.9	0.9	1.6
Neuroticism	0.2	0.4	0.9	-0.6	-0.6	0.1	-0.9	-0.4
Sensitivity / hurt feelings	0.2	0.3	0.6	0.0	0.5	0.6	-0.5	0.8
Average weekly fortified wine intake	0.2	0.2	0.3	0.5	-0.5	-0.3	-0.5	-0.3
Relative age voice broke	0.2	0.3	1.2	1.1	-0.2	-0.5	0.0	-0.1
Multivitamins +/- minerals	0.2	0.2	0.5	-0.5	-0.2	-0.7	-0.5	-0.2
Medication: Atenolol	0.2	0.2	0.7	0.9	-0.5	-0.1	0.1	0.3
Medication: Levothyroxine sodium	0.2	0.3	1.0	-1.0	-0.2	-0.4	-0.4	0.0
Diabetes (self-reported)	0.2	0.3	0.5	0.2	-0.5	-0.1	-0.7	-0.7
Neuroticism score	0.2	0.3	0.7	-0.7	-0.7	0.3	-0.8	-0.1
Number of live births	0.2	0.3	1.0	0.1	-0.6	-0.0	0.2	-1.0
Length of working week for main job	0.2	0.2	0.5	0.5	-0.0	-0.5	0.1	-0.7
Hair/balding pattern: Pattern 4	0.2	0.4	0.9	0.1	-0.6	-0.4	-0.9	-0.9
Medication: Amlodipine	0.2	0.3	0.5	-0.7	0.2	-0.6	-0.6	-0.1
Seen a psychiatrist for nerves, anxiety, tension or depression	0.2	0.2	0.7	-0.1	-0.3	0.6	0.2	0.8
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	0.4	0.4	0.6	0.7	0.0	0.5
Medication: Allopurinol	0.2	0.2	0.4	0.1	0.5	0.2	0.7	0.6
Medication: Omeprazole	0.2	0.2	0.9	-0.9	0.2	0.1	-0.2	0.1
Leg pain on walking	0.2	0.2	0.4	-0.6	0.6	0.1	-0.5	-0.3
Handedness (chirality/laterality): Left-handed	0.2	0.3	1.1	1.1	-0.2	-0.3	-0.3	-0.1
Ever smoked	0.2	0.4	0.9	-1.0	-0.6	-0.1	-0.8	-0.3
Number of operations (self-reported)	0.2	0.3	0.8	-0.1	0.1	0.9	0.3	0.7
Vascular/heart problems diagnosed by doctor	0.2	0.6	1.3	0.3	0.5	-0.5	-1.1	-1.1
Heart attack/myocardial infarction (self-reported)	0.2	0.3	0.7	-0.8	0.4	0.4	0.6	0.3
Alcohol drinker status: Previous	0.2	0.2	0.3	-0.5	-0.6	0.2	0.5	0.3
Bipolar Disorder (2018)	0.1	0.2	0.5	0.6	-0.1	-0.1	-0.7	0.4
Depression (Nagel 2018)	0.1	0.2	0.7	-0.8	-0.1	0.3	0.1	0.2
Neuroticism (Nagel 2018)	0.1	0.3	1.0	0.0	0.1	1.0	-0.3	0.5
Breast Cancer	0.1	0.3	0.9	0.9	0.5	0.2	0.4	0.3
Age at First Birth	0.1	0.1	0.4	-0.3	-0.3	-0.6	-0.1	0.0
HbA1C	0.1	0.2	0.5	-0.1	-0.1	-0.7	-0.3	-0.4
LDL Cholesterol	0.1	0.2	0.5	0.3	-0.5	-0.7	0.2	0.3
Neuroticism (2016)	0.1	0.2	0.4	0.6	0.6	0.1	-0.3	0.2
Heel T-Score	0.1	0.8	2.3	1.5	0.8	0.2	0.3	1.0
Lung FEV1/FVC ratio	0.1	0.7	1.3	0.8	-0.2	-1.2	-0.6	-1.1
Hair Pigment	0.1	4.0	6.9	-1.9	1.7	2.6	0.6	2.6
Tanning	0.1	0.9	2.9	0.2	-0.8	-0.8	-0.2	-1.7
Hand grip strength (left)	0.1	0.4	1.1	0.2	1.1	0.4	0.7	0.4
Number of treatments/medications taken	0.1	0.1	0.5	-0.1	-0.7	0.1	0.1	-0.1
Severe depression (siblings)	0.1	0.1	0.3	-0.1	0.1	0.2	0.0	0.5
Fed-up feelings	0.1	0.2	0.3	-0.4	-0.5	0.3	-0.5	-0.2
Sitting height	0.1	0.9	3.2	0.5	0.6	-0.2	-0.6	-1.8
Chronic bronchitis/emphysema (father)	0.1	0.2	0.6	0.4	0.0	0.8	-0.3	0.2
Body mass index (BMI)	0.1	0.5	1.1	1.1	1.0	0.5	0.2	-0.2
Had menopause	0.1	0.1	0.2	0.4	-0.2	0.5	-0.5	-0.2
Noisy workplace	0.1	0.1	0.1	0.2	0.2	-0.3	-0.3	-0.3
Loud music exposure frequency	0.1	0.2	0.4	-0.6	-0.0	0.2	0.2	0.6
Gout (self-reported)	0.1	0.2	0.7	0.8	0.5	-0.1	0.3	0.1
Hypothyroidism/myxoedema (self-reported)	0.1	0.2	0.6	-0.3	0.5	0.3	-0.0	0.8
Exposure to tobacco smoke outside home	0.1	0.2	0.5	0.7	0.3	0.4	0.2	0.0
Health satisfaction	0.1	0.1	0.2	-0.2	0.0	-0.1	-0.3	-0.5
Shortness of breath walking on level ground	0.1	0.1	0.4	-0.7	0.1	0.0	-0.5	-0.1
Medication for pain relief, constipation, heartburn	0.1	0.1	0.3	0.1	0.6	-0.3	-0.1	-0.6
Medication: Blood pressure	0.1	0.1	0.3	0.1	-0.5	-0.1	0.0	0.5
Migraine (self-reported)	0.1	0.1	0.5	0.3	0.3	0.0	-0.0	0.7
Medication: Seretide 50 evohaler	0.1	0.1	0.4	-0.1	0.3	-0.2	-0.1	0.6
Suffer from ‘nerves’	0.1	0.2	0.3	0.6	-0.5	-0.3	-0.5	0.2
Forced expiratory volume in 1-second (FEV1), predicted	0.1	0.3	0.6	0.4	0.7	0.8	-0.4	0.0
Medication: Blood pressure	0.1	0.1	0.4	0.5	-0.6	-0.1	0.2	-0.2
Medication: Bendroflumethiazide	0.1	0.1	0.2	-0.4	0.1	0.0	0.1	0.5
Diastolic blood pressure, automated reading	0.1	0.4	1.3	-0.4	-0.4	0.3	1.1	-0.2
Medication: Omeprazole (e.g. Zanprol)	0.1	0.1	0.3	-0.5	-0.4	0.2	-0.1	0.1
Heart disease (siblings)	0.1	0.1	0.2	0.2	0.3	0.4	0.1	-0.1
Qualifications: CSEs or equivalent	0.0	0.1	0.3	-0.5	-0.0	-0.2	0.1	-0.1
Mouth/teeth dental problems: Mouth ulcers	0.0	0.1	0.3	-0.2	0.5	0.2	-0.1	0.0
Commuting to job workplace: Public transport	0.0	0.1	0.2	-0.1	-0.1	0.3	0.4	-0.1

Hub : Genes

SUPV3L1

Models

Trait associations