Hub : Genes

HKDC1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	CommonMind	Brain Pre-frontal Cortex	0.0670	0.0280	9.1e-03	0.039	0.010	0.018	0.022	0.022	1.3e-05	1.7e-02	2.6e-03	9.1e-04	9.8e-04
2	NTR	Blood	0.0477	0.0120	3.5e-07	0.007	0.024	0.030	0.026	0.025	2.3e-03	2.0e-08	3.7e-10	7.4e-09	1.4e-08
3	TCGA	Breast Invasive Carcinoma	0.0209	0.0085	4.7e-04	0.019	0.019	0.020	NA	0.018	8.1e-05	7.5e-05	3.9e-05	NA	1.1e-04
4	TCGA	Kidney Renal Clear Cell Carcinoma	0.0568	0.0196	4.3e-06	0.019	0.039	0.026	NA	0.019	3.0e-03	3.0e-05	5.9e-04	NA	2.7e-03
5	TCGA	Kidney Renal Papillary Cell Carcinoma	0.0970	0.0410	2.3e-03	-0.002	0.048	0.030	NA	0.007	4.2e-01	9.9e-04	7.4e-03	NA	1.2e-01
6	TCGA	Lung Adenocarcinoma	0.0381	0.0170	2.8e-03	0.025	0.012	0.011	NA	0.008	6.3e-04	1.2e-02	1.7e-02	NA	3.1e-02
7	TCGA	Lung Squamous Cell Carcinoma	0.0531	0.0216	3.6e-04	0.006	0.031	0.025	NA	0.014	6.2e-02	1.7e-04	6.6e-04	NA	8.5e-03
8	TCGA	Pancreatic Adenocarcinoma	0.1690	0.0750	1.3e-03	0.039	0.054	0.058	NA	0.072	9.3e-03	2.7e-03	1.9e-03	NA	5.9e-04
9	TCGA	Prostate Adenocarcinoma	0.1803	0.0448	4.3e-14	0.141	0.123	0.159	NA	0.161	1.6e-14	7.6e-13	2.3e-16	NA	1.7e-16
10	TCGA	Thyroid Carcinoma	0.1410	0.0370	4.2e-10	0.114	0.087	0.141	NA	0.143	3.3e-11	7.8e-09	1.2e-13	NA	8.2e-14

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7	8	9	10
Bipolar Disorder (2018)	0.7	1.1	3.1	0.2	0.7	-0.8	-1.1	-1.8	-1.1	-1.4	-1.0	-1.3	-0.3
Bipolar Disorder or Schizophrenia	0.4	1.0	2.6	0.5	1.6	-1.5	-1.2	-1.0	-0.7	-0.5	-0.8	0.2	-1.1
Depressed Affect (Nagel 2018)	0.8	1.6	4.3	-1.1	-1.5	-0.4	0.0	-1.4	-1.5	-1.8	-0.9	-2.1	-0.2
Depression (Nagel 2018)	0.7	1.0	2.4	-1.5	-0.1	-0.8	-0.1	-1.2	-1.3	-1.1	-0.9	-1.1	-0.7
Intelligence (Savage-Jansen 2018)	1.7	5.2	9.7	0.4	1.9	2.3	2.6	3.1	2.8	3.1	2.0	1.3	1.9
Neuroticism (Nagel 2018)	0.8	1.8	5.1	-1.3	-0.5	-0.7	-0.4	-1.8	-1.7	-1.5	-0.8	-2.3	-1.1
Schizophrenia (2018)	0.4	0.8	2.6	0.4	1.6	-1.3	-0.7	0.1	-0.0	0.5	-0.3	1.3	-1.1
Schizophrenia vs Biploar Disorder	0.7	1.0	3.6	-0.5	-0.1	-1.3	-1.4	-1.1	-0.8	0.1	0.0	-0.3	-1.9
Worry (Nagel 2018)	0.7	1.5	3.2	-1.2	-0.4	-1.8	-1.1	-1.3	-1.7	-0.3	-1.1	-1.6	-0.7
Alzheimer’s Disease (in mother)	0.9	1.1	2.2	-1.5	1.4	0.3	0.8	0.5	0.8	-0.9	1.4	1.5	0.2
Alzheimer’s Disease (in father)	0.8	0.9	2.1	0.4	1.2	-1.4	-0.5	0.7	0.7	1.3	-0.8	0.9	0.9
Alzheimer’s Disease (including proxy)	0.9	1.3	3.6	-0.3	1.9	-0.9	0.1	1.1	1.4	0.9	0.4	1.9	1.0
Crohns Disease (2017)	0.3	0.7	3.0	0.7	-0.6	-0.3	-0.9	-1.1	-0.7	-0.5	-0.2	-1.7	0.6
Irritable Bowel Disease (IBD)	0.3	0.6	2.6	-1.1	0.2	-0.0	0.1	-1.0	-0.7	-0.7	0.3	-1.6	-0.0
Ulcerative Colitis (UC)	0.3	0.5	2.2	-1.5	0.6	0.0	0.8	-0.3	-0.6	-0.8	0.2	-0.8	-0.3
Major Depression (MDD)	0.8	1.0	2.8	1.7	0.5	-1.2	-0.5	0.8	0.8	0.8	-0.9	1.2	-1.1
Reaction Time	0.5	1.0	4.6	0.3	-0.2	-2.1	-1.2	1.0	-0.1	1.5	-0.7	0.5	0.5
Verbal and Numeric Reasoning (VNR)	0.9	2.1	6.0	0.7	-0.5	1.3	1.5	2.4	1.5	2.3	1.1	1.3	0.4
Breast Cancer	0.3	0.8	2.5	0.3	0.9	1.2	1.6	0.7	0.7	0.8	0.8	0.9	-0.4
Ovarian Cancer	1.1	1.4	3.3	1.1	-1.4	-1.3	-1.6	-1.1	-0.3	-0.1	-1.4	-1.8	0.4
Prostate Cancer	6.8	9.5	20.8	0.6	-4.0	-3.3	-3.1	-2.2	-4.6	-2.0	-3.5	-2.8	-3.0
Age at First Birth	0.3	0.5	1.2	0.2	-1.0	-0.3	0.0	-1.0	-0.5	-0.6	-1.1	-0.7	-0.7
Bipolar Disorder (2011)	0.2	0.2	1.3	-0.5	-1.1	0.0	0.0	0.0	0.0	0.0	0.0	0.0	0.0
Body Mass Index (BMI) (2010)	0.5	0.7	2.9	-1.7	0.2	0.1	0.9	0.8	-0.9	-0.5	-0.2	-1.0	-0.3
Coronary Artery Disease (CAD)	1.4	1.7	4.8	0.9	-0.9	-1.1	-1.7	-1.0	-1.3	-1.2	-1.5	-0.0	-2.2
Crohns Disease (2012)	0.4	0.7	2.4	0.5	-0.6	0.4	0.4	-0.3	-1.1	-1.3	-0.1	-1.6	0.8
Mean Putamen Volume	0.4	0.4	1.4	-0.1	-1.2	0.1	-0.5	-0.4	-1.0	-0.3	-0.5	-1.0	-0.4
Fasting Glucose	5.4	6.4	17.2	-1.5	3.1	1.9	1.9	1.8	2.2	1.9	4.1	1.9	3.6
HbA1C	0.8	0.9	4.1	-2.0	0.2	-1.6	-0.0	-0.4	-1.1	0.3	-0.0	0.4	-1.0
HDL Cholesterol	0.3	0.4	1.5	-0.8	-0.2	-0.5	-0.0	-1.1	-0.4	-0.4	-0.0	-1.2	-0.4
LDL Cholesterol	0.3	0.5	1.8	-1.3	0.8	0.2	-0.2	0.1	0.6	0.6	0.9	-0.1	0.9
Lupus	3.2	4.8	12.9	-1.6	0.4	-0.9	-1.5	-3.5	-2.3	-3.6	-0.9	-3.2	-0.8
Neuroticism (2016)	0.3	0.4	1.2	0.4	-1.1	-0.1	0.4	0.1	-0.5	-0.3	-0.7	-0.6	0.9
Primary Biliary Cirrhosis	0.1	0.2	0.5	0.7	0.7	-0.1	0.1	-0.4	-0.2	-0.4	0.1	0.7	-0.1
Rheumatoid Arthritis	0.4	0.5	1.3	1.2	-0.5	0.6	0.5	-0.2	-0.4	-1.1	-0.8	-0.8	0.2
Schizophrenia (2014)	0.3	0.7	2.5	0.3	1.5	-1.6	-1.2	-0.2	-0.6	0.3	-0.1	0.6	-0.4
Triglycerides	1.0	1.7	4.9	-0.9	1.4	1.3	0.9	1.3	0.8	0.7	2.2	1.4	1.5
Type 2 Diabetes (T2D) (2012)	0.2	0.2	0.9	0.5	0.2	-0.3	0.0	-0.5	0.1	-0.7	-0.5	0.3	-0.9
Ulcerative Colitis	0.4	0.6	1.7	-1.3	0.4	-0.5	-0.2	-0.5	-0.9	-0.7	-0.5	-1.2	-0.6
Blood Eosinophil Count	0.3	2.7	8.6	2.9	0.5	0.3	-0.3	1.4	2.2	2.0	-1.5	1.6	1.3
Blood Platelet Count	0.9	10.3	34.6	-3.7	2.2	3.8	3.7	1.6	1.5	-0.2	4.1	0.1	5.9
Blood Red Count	0.9	8.3	15.6	2.2	-3.2	-2.0	-3.5	-2.0	-3.0	-2.3	-3.3	-4.0	-2.5
Blood White Count	0.9	6.7	17.9	-1.7	2.9	4.2	3.7	1.1	1.4	-0.9	3.1	-0.8	3.1
Heel T-Score	0.2	1.9	6.5	0.6	0.1	1.6	1.4	0.3	2.1	0.8	1.2	0.1	2.5
BMI	0.1	0.7	1.6	-1.0	0.0	-1.1	-0.9	0.2	-1.0	0.4	-1.1	-0.0	-1.2
Height	0.2	4.4	10.0	2.5	-3.2	-2.4	-2.1	-1.1	-2.0	-0.3	-2.5	-2.3	1.0
Waist Hip Ratio (WHR)	0.2	0.7	2.4	-0.1	-0.1	0.8	1.2	0.6	0.4	0.7	1.1	-0.2	1.5
Systolic Blood Pressure	0.6	2.9	9.9	-3.1	1.9	1.6	1.7	0.2	0.1	-1.1	2.1	-1.0	1.9
Smoking Status	0.2	0.6	2.0	1.0	0.6	0.4	-0.3	-0.2	0.8	-0.5	0.7	1.4	0.9
Allergy or Eczema	0.1	0.3	1.1	0.2	0.3	-0.7	0.2	-0.2	0.8	0.4	-1.1	0.6	-0.5
Cardiovascular Disease	0.3	0.9	2.4	-0.6	1.6	1.1	1.5	0.2	0.1	-0.4	1.2	-0.5	1.0
Hypothyroidism (self reported)	0.3	0.6	2.0	-0.2	-0.9	1.2	0.3	0.1	0.8	-0.1	1.4	0.5	1.0
Respiratory disease	0.2	0.4	0.8	0.8	0.4	-0.7	-0.9	0.6	0.6	0.5	-0.0	0.7	-0.8
Type 2 Diabetes (T2D) (2018)	0.7	1.3	6.9	2.6	-0.8	0.3	0.7	0.7	1.2	0.4	-0.1	1.7	-0.7
Lung FEV1/FVC ratio	0.4	2.1	6.9	1.6	0.7	0.3	0.7	2.4	1.6	2.6	-0.2	1.1	0.9
Lung FVC	3.0	15.3	38.3	-0.9	2.5	4.7	4.7	2.9	3.8	1.7	6.2	2.9	5.4
Neuroticism	0.1	0.3	0.6	0.3	0.6	-0.8	-0.5	-0.7	-0.4	0.2	0.4	-0.5	-0.8
Chronotype (morning person)	0.6	1.4	5.2	1.3	-0.0	-1.7	-1.3	-0.0	-0.1	1.0	-2.3	-0.3	-1.4
Hair Pigment	0.0	0.8	2.6	0.1	0.7	1.6	0.4	-0.7	0.2	-0.5	1.5	-0.5	1.4
Tanning	0.1	1.8	4.5	-0.3	-1.9	-1.6	-1.1	-0.9	-1.2	-0.6	-2.1	-0.7	-1.5
Hand grip strength (left)	0.5	1.4	3.0	-0.8	1.2	1.7	1.5	0.7	1.6	0.4	1.2	1.4	0.3
Number of treatments/medications taken	0.1	0.2	1.0	1.0	-0.3	-0.0	0.3	0.8	-0.1	0.4	-0.3	-0.1	0.5
Average weekly spirits intake	1.7	2.1	6.1	0.7	-2.5	-0.7	-0.9	-1.8	-1.9	-1.9	-0.7	-1.2	-0.5
Sensitivity / hurt feelings	0.7	1.2	3.9	-0.6	2.0	0.8	1.0	-0.3	1.0	-0.1	2.0	-0.0	1.1
Frequency of depressed mood in last 2 weeks	0.5	0.7	2.0	-0.1	0.3	-1.1	-0.3	-0.8	-1.3	-1.4	-1.1	-0.5	-0.4
Hearing difficulty/problems: Yes	0.4	0.6	1.8	0.4	0.8	-0.7	-0.6	0.7	0.9	1.3	-0.2	1.3	-0.1
Relative age of first facial hair	0.4	0.9	2.7	-1.6	0.2	1.6	0.8	-0.4	0.1	-0.9	1.0	-1.0	0.6
Other serious medical condition/disability diagnosed by doctor	0.6	0.8	1.3	0.8	-0.6	1.1	0.9	0.9	1.1	0.9	-0.9	0.3	1.1
Ever used hormone-replacement therapy (HRT)	0.7	0.9	2.0	1.1	-0.5	-0.3	-1.2	-0.7	-1.3	-1.3	-0.2	-0.3	-1.4
Ever had hysterectomy (womb removed)	0.3	0.3	1.1	0.8	0.4	0.4	0.2	0.5	0.3	0.1	-0.1	0.9	-1.1
Systolic blood pressure, automated reading	0.3	0.9	4.7	-2.2	-0.2	-0.5	-0.3	-0.3	-1.4	-0.6	0.1	-1.3	-0.1
Eye problems/disorders: Diabetes related eye disease	1.8	2.0	10.9	3.3	-1.2	-0.7	-1.6	0.9	0.3	0.9	-0.8	1.4	-0.4
Angina	0.2	0.3	2.4	-0.2	-0.2	0.3	0.1	0.2	0.5	0.0	0.4	-0.3	1.6
Medication for hormone replacement therapy	0.4	0.4	2.1	-0.2	0.4	0.4	0.2	-0.0	-0.5	-0.8	1.5	0.7	-0.1
Vitamin and mineral supplements	0.1	0.2	0.4	-0.5	0.3	0.6	0.7	0.1	-0.3	-0.4	0.6	-0.4	0.3
Supplements: Zinc	0.5	0.6	3.4	0.3	0.2	-1.0	-0.8	0.3	-0.1	0.1	-1.8	-0.3	-0.5
Medication: Co-codamol	2.2	2.6	6.0	2.5	-0.8	0.6	1.1	2.0	1.6	1.6	0.1	2.1	1.9
Medication: Metformin	0.6	0.9	4.4	1.1	-2.1	-0.5	0.2	0.4	-0.5	-0.4	-0.1	1.6	-0.2
Diabetes (father)	0.6	0.7	3.5	-0.3	0.3	-0.9	-1.0	-0.4	-0.5	-0.8	-0.4	0.4	-1.9
Diabetes (mother)	1.4	1.8	5.5	2.3	-1.4	-1.9	-1.4	-0.3	-1.2	0.3	-1.4	-0.3	-1.1
Severe depression (siblings)	0.6	0.6	3.7	-0.4	-0.2	0.1	-0.4	-0.9	-0.7	-0.7	-0.8	-1.9	0.1
Pack years adult smoking proportion	0.6	0.8	2.8	-0.6	-0.1	1.1	1.7	1.2	0.1	-0.6	1.4	0.3	0.5
Impedance of leg (right)	0.4	2.1	4.7	-2.2	1.5	1.1	0.5	-1.4	-0.4	-1.7	1.7	-1.5	1.6
Leg fat-free mass (left)	0.3	1.4	4.2	2.0	-1.9	-1.6	-1.0	0.7	-0.4	1.0	-1.2	0.4	-0.5
Trunk fat percentage	0.2	0.6	1.7	-0.1	-0.1	-0.6	-1.2	-1.3	-1.2	-1.0	0.3	-0.5	-0.1
Hand grip strength (right)	0.5	1.3	2.8	-1.6	1.5	1.7	1.6	0.1	1.3	-0.1	1.2	0.3	-0.2
Townsend deprivation index at recruitment	0.2	0.2	1.3	0.3	-0.3	0.1	-0.3	-0.5	-0.6	-1.1	-0.1	-0.3	0.1
Current tobacco smoking	0.5	0.9	3.5	-0.6	0.4	-0.4	-0.4	-1.6	-0.8	-1.9	0.8	-0.2	0.8
Average weekly fortified wine intake	0.4	0.5	1.8	1.0	0.1	-1.3	-1.1	0.1	-0.5	-0.3	0.4	0.8	0.2
Maternal smoking around birth	0.4	0.5	2.6	1.0	-0.1	0.6	-0.0	-0.7	-0.2	-1.6	-0.5	-0.2	0.7
Fed-up feelings	0.0	0.1	0.3	0.0	-0.2	-0.2	-0.1	0.5	0.1	0.3	0.2	-0.5	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.1	0.1	0.3	-0.2	0.1	-0.4	0.4	0.2	0.0	0.0	-0.1	0.0	0.5
Relative age voice broke	0.4	0.6	1.8	-1.1	1.1	0.9	1.3	0.3	0.8	-0.1	0.0	-0.1	-0.1
Taking other prescription medications	0.9	1.4	3.3	0.7	-0.3	0.7	0.9	1.8	1.4	1.6	0.9	1.5	1.2
Age when periods started (menarche)	1.2	3.0	10.7	0.5	3.3	1.4	1.1	1.2	2.3	1.4	1.1	0.4	2.3
Bilateral oophorectomy (both ovaries removed)	0.6	0.7	3.1	0.6	0.5	-1.0	-1.8	0.0	-1.3	0.7	-0.5	0.2	-0.5
Heel bone mineral density (BMD) T-score, automated (left)	1.3	3.0	6.2	1.4	1.6	1.2	1.9	1.9	2.4	1.5	1.4	2.5	0.6
Tinnitus: Yes, but not now, but have in the past	0.3	0.4	1.7	-0.7	0.4	-0.4	0.1	0.1	-0.6	-1.3	-0.6	0.4	-0.3
Qualifications: CSEs or equivalent	0.4	0.6	4.0	-2.0	0.5	0.7	0.6	-0.2	0.4	-0.3	0.3	0.6	-0.4
Serious illness, injury or assault to yourself	1.0	1.3	3.5	-1.9	0.1	0.9	1.9	0.0	-1.0	-1.5	0.6	-1.0	-0.3
High blood pressure	0.9	2.4	6.2	-0.3	2.5	1.2	2.3	1.6	1.2	0.8	1.8	0.5	1.8
Hayfever, allergic rhinitis or eczema	0.2	0.4	1.8	-0.0	0.2	-0.4	0.4	-0.9	0.8	-0.1	-0.9	0.3	-1.3
Multivitamins +/- minerals	0.1	0.1	0.4	0.1	0.1	-0.1	-0.6	-0.4	0.2	0.4	-0.1	0.2	-0.6
Stomach or abdominal pain in last month	0.5	0.7	2.7	-1.6	-0.0	0.6	1.3	-0.1	-0.2	-1.1	0.6	-0.4	-0.3
Supplements: Glucosamine	1.9	2.5	5.2	-0.2	-0.4	-1.7	-2.3	-2.3	-1.5	-1.2	-1.6	-0.9	-2.1
Diverticular disease/diverticulitis (self-reported)	1.7	2.0	3.8	0.9	-1.9	-1.0	-1.9	-1.5	-1.8	-1.3	-1.2	-1.0	-1.1
Medication: Atenolol	0.3	0.3	2.1	-0.1	0.4	-0.2	-0.2	-0.5	0.4	-0.1	-0.6	-0.6	1.4
Medication: Levothyroxine sodium	0.5	0.8	3.0	0.2	-0.3	0.2	0.0	1.1	0.9	0.9	1.0	1.7	0.8
Sitting height	0.2	1.3	5.5	1.6	-2.4	-1.6	-0.6	0.2	-0.5	0.5	-0.8	-0.8	0.2
Chronic bronchitis/emphysema (father)	0.9	1.1	2.7	0.2	-0.5	-0.8	-1.6	-1.6	-1.0	-1.1	-0.8	-0.5	-1.3
High blood pressure (mother)	0.6	0.8	2.6	0.9	-1.0	-0.6	-0.9	-0.1	-0.9	0.0	-1.6	-1.1	-0.6
Body mass index (BMI)	0.1	0.5	2.1	0.2	-0.5	-0.6	-0.6	0.7	-0.5	0.6	0.1	1.4	-0.6
Impedance of leg (left)	0.4	2.1	4.9	-1.9	2.1	1.2	0.6	-1.3	0.1	-1.5	2.2	-0.7	1.4
Leg predicted mass (left)	0.3	1.5	4.0	2.0	-1.9	-1.6	-1.0	0.7	-0.4	1.0	-1.2	0.4	-0.5
Trunk fat mass	0.1	0.4	1.4	0.5	-0.6	-0.9	-1.2	-0.5	-1.0	-0.4	0.2	0.2	0.0
Waist circumference	0.1	0.4	1.3	-0.1	-0.2	0.1	0.1	0.6	0.0	0.5	1.1	0.7	1.1
Number of incorrect matches in round	1.4	2.3	4.8	0.9	-1.0	-1.7	-1.6	-1.3	-1.9	-1.4	-2.2	-1.3	-1.6
Past tobacco smoking	0.5	0.9	2.3	-0.6	-0.5	-0.8	-0.6	-1.2	-1.5	-1.3	-0.2	-1.4	-0.1
Alcohol usually taken with meals	0.3	0.6	2.6	1.2	-0.4	-0.8	-0.4	-0.0	0.3	0.4	-1.6	0.3	-0.5
Nervous feelings	0.3	0.6	1.7	-0.3	-0.0	-1.3	-0.7	-1.0	-1.0	-1.0	-0.6	-0.1	-0.2
Frequency of tenseness / restlessness in last 2 weeks	1.1	1.7	6.0	-1.1	0.4	-1.1	-0.6	-1.7	-1.9	-2.5	-0.5	-1.1	-0.6
Hearing difficulty/problems with background noise	0.4	0.6	2.2	-1.0	-0.2	-1.5	-1.1	-0.5	-0.5	-0.1	-0.8	0.5	-0.8
Hair/balding pattern: Pattern 2	0.3	0.4	1.7	0.1	0.4	0.8	0.7	-0.1	-0.9	-0.3	-0.0	-1.3	0.6
Had menopause	2.6	3.3	10.4	0.6	-2.4	-2.2	-3.2	-1.4	-2.2	-1.0	-1.7	-0.4	-0.6
Had other major operations	0.3	0.4	1.2	0.4	-0.1	0.4	0.2	0.7	0.0	1.0	0.8	0.2	1.1
Forced vital capacity (FVC)	0.9	3.3	12.3	0.7	-0.2	1.8	1.7	1.5	1.8	1.6	2.2	1.1	3.5
Heel bone mineral density (BMD) T-score, automated (right)	1.4	3.2	7.0	0.8	2.6	1.1	1.7	1.6	2.5	1.4	1.9	2.4	0.8
Ever unenthusiastic/disinterested for a whole week	0.8	0.9	3.4	-1.8	0.6	0.7	1.1	-0.1	0.5	-0.8	1.1	-0.4	1.2
Qualifications: None of the above	0.1	0.2	0.8	-0.1	0.1	-0.4	-0.4	0.4	-0.2	0.1	0.9	-0.1	0.7
Financial difficulties in last 2 years	0.7	1.0	2.3	-0.2	-0.4	1.0	1.5	-0.7	1.0	-1.0	0.5	1.2	1.4
Mouth/teeth dental problems	1.5	2.3	8.3	1.0	-0.1	0.3	0.7	2.2	1.2	2.9	0.9	2.4	0.2
Heart attack	0.7	0.9	2.4	0.0	-1.5	-0.2	-1.0	-1.3	-0.8	-1.4	-0.4	-1.1	-0.5
Allergy	0.3	0.6	2.7	-0.5	-0.2	0.8	0.4	0.8	-0.2	0.5	1.0	-0.4	1.6
Pain all over the body in last month	1.2	1.3	3.0	1.5	0.1	1.5	-0.1	0.7	1.6	1.0	1.0	0.4	1.7
Diabetes (self-reported)	0.8	1.2	5.2	1.9	-2.3	-0.0	-0.2	0.4	0.1	-0.1	-0.7	0.9	-1.2
Hayfever/allergic rhinitis (self-reported)	0.2	0.3	1.5	0.2	0.6	0.3	0.5	-0.0	1.2	0.8	0.0	-0.6	-0.0
Medication: Ramipril	0.7	1.0	2.6	-0.5	1.6	0.7	1.3	0.7	0.8	0.6	0.9	0.2	1.4
Medication: Simvastatin	0.3	0.5	1.2	1.1	-1.0	-0.7	-0.5	-0.6	-0.4	-0.4	-1.0	0.3	-0.4
Fluid intelligence score	1.7	3.5	8.5	1.3	0.5	1.7	1.8	2.8	2.3	2.9	1.4	1.7	0.9
Illnesses of siblings	2.0	2.8	6.8	-0.7	2.2	2.4	2.6	0.8	2.2	0.9	1.9	0.4	0.6
Neuroticism score	0.1	0.1	0.4	0.3	0.0	-0.6	-0.2	-0.5	-0.1	0.1	0.5	-0.4	0.1
Weight	0.2	1.0	2.7	1.3	-1.3	-1.6	-1.2	0.6	-0.7	0.9	-0.6	0.8	-0.2
Impedance of arm (right)	0.3	1.6	4.9	-0.7	1.3	1.1	-0.0	-2.1	-0.5	-1.4	0.8	-2.2	0.8
Arm fat percentage (right)	0.0	0.2	0.6	-0.1	-0.1	-0.0	-0.6	-0.4	-0.6	-0.4	0.8	0.6	0.1
Trunk fat-free mass	0.4	2.3	5.5	2.3	-2.1	-2.1	-1.2	1.4	-0.1	1.5	-1.1	1.3	-0.1
Hip circumference	0.1	0.4	0.9	0.7	-0.2	0.2	-0.3	0.9	0.0	0.8	0.9	0.8	0.8
Time employed in main current job	0.3	0.3	1.9	0.2	1.4	-0.2	-0.3	0.7	-0.5	0.7	-0.1	-0.4	-0.1
Alcohol intake versus 10 years previously	1.3	2.0	6.2	-1.1	0.2	2.2	1.9	0.3	0.8	0.4	2.5	0.7	1.7
Father’s age at death	0.7	0.9	2.1	0.8	1.3	-0.2	-1.3	1.4	0.4	1.1	-0.4	0.5	1.0
Worrier / anxious feelings	0.2	0.4	2.4	-0.7	0.5	-0.1	0.0	-0.5	-0.5	0.1	0.1	-1.5	0.9
Frequency of tiredness / lethargy in last 2 weeks	1.0	1.7	4.8	0.8	-1.7	-0.9	-1.5	-2.2	-1.4	-1.6	-0.7	-0.5	-0.3
Falls in the last year	0.4	0.6	2.1	-0.6	0.9	0.7	0.5	-0.1	-0.6	-0.8	0.4	-0.8	1.5
Hair/balding pattern: Pattern 3	0.3	0.5	1.6	-0.2	-0.4	0.4	0.2	0.7	1.1	1.0	-0.2	0.2	1.3
Number of live births	1.9	2.7	11.3	0.8	-3.4	-1.8	-1.3	-0.9	-2.0	-0.3	-1.6	-1.3	-1.1
Forced expiratory volume in 1-second (FEV1)	1.1	3.6	9.4	0.2	0.6	1.9	2.0	1.9	2.2	1.9	2.3	1.2	3.1
Pulse rate	0.4	0.6	2.7	-0.5	-1.2	-0.4	-0.1	0.5	-0.8	0.2	-0.8	-1.6	0.5
Happiness	0.8	1.0	3.4	-0.2	-0.8	0.6	1.2	1.8	0.6	1.1	-0.1	0.4	1.6
Noisy workplace	0.9	1.1	2.9	-0.2	1.1	0.7	0.4	1.4	1.4	1.1	0.9	1.7	0.7
Qualifications: A levels/AS levels or equivalent	0.5	1.0	2.4	0.0	0.8	1.1	1.6	1.1	1.5	1.0	0.4	0.1	-1.1
Serious illness, injury or assault of a close relative in last 2 years	0.2	0.3	1.2	0.6	-0.6	-0.4	-0.1	0.2	0.1	0.6	-1.1	-0.2	-0.3
Mouth/teeth dental problems: Dentures	0.5	0.9	3.2	-0.3	0.0	0.6	0.1	-0.8	-0.6	-1.6	0.0	-1.2	1.8
Asthma	0.4	0.7	1.4	0.8	1.1	-0.9	-1.1	0.3	0.4	0.1	0.8	1.2	-1.0
Medication: Ibuprofen (e.g. Nurofen)	2.2	2.8	6.0	-0.4	1.7	2.5	2.4	1.4	1.6	1.3	2.2	0.7	1.0
Medication: Cholesterol lowering	0.6	0.9	2.4	0.9	-1.5	-1.2	0.2	-0.8	-0.8	-1.1	-1.1	0.7	-0.8
Depression (self-reported)	0.2	0.2	0.6	0.3	-0.4	0.2	0.8	0.4	0.6	0.6	-0.5	0.0	0.4
Medication: Lansoprazole	0.3	0.4	1.3	0.3	0.5	1.0	0.3	-0.1	0.1	-0.1	0.9	-0.1	1.1
Prospective memory result	0.7	0.9	3.0	-0.5	1.7	-0.9	-1.0	0.2	1.1	0.6	0.6	1.2	0.8
Lung cancer (father)	1.1	1.3	3.5	-0.6	-1.2	-0.3	-0.1	-0.9	-0.8	-1.5	-1.3	-1.4	-1.9
Illnesses of mother	2.7	3.4	8.3	-0.6	1.2	2.3	2.6	1.7	1.7	0.7	2.9	1.2	2.0
Forced expiratory volume in 1-second (FEV1), Best measure	1.4	4.5	10.1	-0.1	0.9	2.3	2.7	2.3	2.3	2.1	2.3	0.7	3.2
Pulse wave Arterial Stiffness index	1.9	2.3	6.8	2.1	-1.2	-1.7	-2.6	-1.4	-1.4	-1.2	-1.0	-0.6	-0.5
Impedance of arm (left)	0.5	2.2	6.7	-1.1	1.4	1.8	0.6	-1.7	-0.2	-1.4	1.2	-2.6	1.3
Arm fat mass (right)	0.1	0.3	0.8	0.6	-0.7	-0.7	-0.9	-0.0	-0.6	0.2	0.0	0.7	-0.1
Trunk predicted mass	0.4	2.3	5.8	2.4	-2.1	-2.1	-1.2	1.4	-0.2	1.5	-1.1	1.3	-0.2
Standing height	0.2	2.4	6.9	2.6	-1.8	-2.2	-1.6	-0.2	-0.6	0.6	-1.7	-1.4	0.8
Length of working week for main job	0.7	0.8	2.1	1.1	-1.2	-0.5	-0.3	-1.4	-0.4	-1.1	-0.9	-0.0	-0.8
Exposure to tobacco smoke at home	2.0	2.3	8.3	0.6	1.2	1.5	1.5	1.8	2.9	1.1	0.8	1.4	1.1
Breastfed as a baby	0.7	0.9	2.6	0.9	-0.3	-0.3	-0.6	-1.3	-0.9	-1.6	-0.3	-1.4	0.5
Tense / ‘highly strung’	0.9	1.5	5.5	-0.5	0.2	-2.3	-1.4	-1.2	-1.8	-0.5	-1.0	-0.5	-1.1
Seen doctor (GP) for nerves, anxiety, tension or depression	0.3	0.5	3.2	-1.8	-0.4	0.3	0.7	-0.5	-0.4	-0.2	0.7	0.3	0.3
Hair/balding pattern: Pattern 4	0.5	1.1	3.3	0.8	-1.8	-1.4	-1.6	-0.6	-0.7	-0.2	-0.7	0.7	-0.9
Birth weight of first child	6.7	12.2	27.1	0.5	-4.1	-5.2	-3.0	-2.0	-3.4	-0.0	-5.1	-1.7	-5.0
Peak expiratory flow (PEF)	0.6	1.4	3.9	0.3	-0.7	2.0	1.5	1.5	1.0	1.0	1.2	0.2	1.0
Pulse wave reflection index	0.9	1.1	5.7	2.4	0.7	-0.6	-1.2	-0.7	-0.2	-1.2	-0.2	0.9	-0.7
Ever highly irritable/argumentative for 2 days	1.3	1.5	6.0	-1.5	1.2	1.8	0.9	0.2	0.5	-0.0	2.4	-0.2	1.0
Loud music exposure frequency	0.1	0.1	0.7	-0.1	-0.0	0.3	-0.2	-0.3	0.5	-0.3	0.4	-0.2	0.8
Qualifications: O levels/GCSEs or equivalent	0.3	0.6	1.9	-1.0	0.0	1.0	1.4	0.2	0.1	0.3	1.2	0.0	-0.3
Mouth/teeth dental problems: Bleeding gums	0.7	0.9	2.0	-0.5	0.3	-0.8	-0.6	-1.1	-0.2	-1.2	-0.9	-1.3	-1.4
Blood clot in the leg (DVT)	0.5	0.7	2.2	0.2	0.9	0.4	-0.4	-1.0	-0.9	-1.2	-0.2	-1.5	0.4
Medication: Paracetamol	0.2	0.3	0.9	-0.1	-0.4	0.0	-0.6	-0.1	-1.0	0.0	-0.2	-0.9	-0.6
Headache pain in last month	0.3	0.6	1.7	-1.2	-1.3	-1.0	0.1	0.1	-0.7	-0.3	-0.2	-0.2	-1.1
Medication for cholesterol, blood pressure or diabetes	0.6	1.0	3.1	-1.7	0.4	-0.4	-1.8	-0.6	-0.9	0.3	0.2	-1.1	-1.0
Glaucoma (self-reported)	1.1	1.3	4.0	2.0	-0.4	-1.6	-1.7	-0.3	-1.2	-0.1	-1.4	-0.1	-0.8
Gout (self-reported)	0.3	0.4	1.7	-0.2	-0.3	-0.7	-1.3	-0.1	-1.0	-0.4	-0.5	-0.7	-0.1
Hypothyroidism/myxoedema (self-reported)	0.6	1.1	2.7	-0.1	-0.1	1.2	0.6	0.8	1.6	0.7	1.5	1.5	1.0
Medication: Amlodipine	0.4	0.5	1.2	-0.3	1.1	0.5	1.1	0.7	0.8	0.3	0.4	1.1	0.4
Medication: Ventolin 100micrograms inhaler	0.3	0.4	1.7	-0.3	-0.2	-1.3	-0.1	-0.2	-0.5	-0.6	-0.8	0.1	-0.8
Birth weight	13.8	30.0	64.5	1.4	-4.0	-8.0	-7.2	-4.4	-5.7	-2.1	-6.9	-2.6	-7.4
Chronic bronchitis/emphysema (mother)	0.5	0.6	1.5	0.7	0.3	-0.8	-1.1	0.1	0.3	1.2	-1.1	0.5	-0.6
High blood pressure (siblings)	0.5	0.7	2.4	0.6	-0.8	-1.5	-1.5	0.4	-1.0	0.4	-0.5	0.0	0.1
Forced vital capacity (FVC), Best measure	1.2	4.3	11.8	-0.1	0.4	2.6	2.8	1.9	2.1	1.6	2.5	0.3	3.4
Body fat percentage	0.1	0.3	0.8	-0.1	-0.1	-0.3	-0.8	-0.8	-0.9	-0.8	0.7	0.1	-0.0
Leg fat percentage (right)	0.2	0.6	1.6	-1.0	-0.3	-0.4	-0.7	-0.5	-1.3	-0.9	1.1	0.5	0.2
Arm fat-free mass (right)	0.3	1.7	4.3	1.6	-1.9	-2.1	-0.9	1.1	-0.2	1.1	-1.1	1.3	-0.5
Exposure to tobacco smoke outside home	0.3	0.5	1.3	-1.0	0.1	0.5	0.4	1.1	0.6	1.1	0.2	0.3	0.4
Comparative body size at age 10	2.8	7.6	19.8	2.5	-2.3	-4.5	-3.1	-0.1	-1.7	0.7	-4.0	1.6	-3.6
Number of full brothers	0.9	1.2	3.6	1.9	0.5	1.6	1.3	0.3	1.0	-0.9	0.9	0.9	0.3
Worry too long after embarrassment	0.4	0.7	3.3	-0.9	1.8	0.1	0.1	-0.8	1.0	0.3	0.5	-0.0	-0.8
Seen a psychiatrist for nerves, anxiety, tension or depression	0.5	0.7	2.5	-1.6	-1.3	0.1	0.8	-0.6	-0.8	-0.4	-0.4	-0.9	-0.1
Wheeze or whistling in the chest in last year	0.7	1.3	5.7	2.4	0.5	-1.6	-1.1	-0.2	0.6	-0.1	-0.5	1.5	-0.5
Number of children fathered	0.4	0.4	1.8	0.1	1.3	0.3	0.5	0.1	0.1	-0.1	1.3	0.6	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.2	0.2	1.2	0.5	-0.0	0.5	0.2	0.5	-0.2	1.1	0.2	0.4	-0.0
Age at first live birth	0.1	0.2	0.5	-0.4	-0.7	0.2	0.6	0.5	-0.1	0.4	0.2	-0.0	0.3
Pulse wave peak to peak time	1.8	2.1	6.2	-2.0	1.0	1.7	2.5	1.4	1.4	1.4	0.9	0.4	0.7
Health satisfaction	0.1	0.1	0.2	-0.1	-0.3	-0.1	0.4	0.1	0.4	0.2	-0.5	0.2	0.2
Shortness of breath walking on level ground	0.1	0.1	0.7	-0.1	-0.8	-0.4	-0.1	0.1	-0.4	-0.3	-0.0	0.4	0.4
Qualifications: College or University degree	0.3	1.0	3.0	1.1	-0.8	-0.6	-0.4	-0.2	-0.5	-0.8	-1.6	-0.9	-1.7
Eye problems/disorders: None of the above	1.9	2.2	6.8	-1.3	1.8	1.6	1.6	-0.3	1.5	-0.4	2.6	0.7	1.6
Mouth/teeth dental problems: Loose teeth	1.1	1.3	3.9	-2.0	0.8	1.8	1.4	-0.2	0.2	-0.6	1.0	-1.4	0.3
Emphysema/chronic bronchitis	0.3	0.4	1.2	-0.3	-0.5	-0.2	-0.4	0.9	0.8	0.4	-0.2	1.1	0.3
Medication for pain relief, constipation, heartburn	0.2	0.4	1.0	-0.9	-0.0	-1.0	-0.4	-0.7	-0.6	-0.5	-0.6	-0.0	-0.7
Neck or shoulder pain in last month	2.8	3.9	9.7	-0.1	-2.0	-3.1	-2.4	-1.8	-2.2	-1.3	-2.1	-0.9	-2.1
Medication: Blood pressure	0.7	1.2	3.8	1.4	0.4	1.0	1.7	0.6	1.1	-0.2	0.1	0.6	1.9
Angina (self-reported)	0.3	0.4	2.8	-0.3	-0.0	0.3	0.1	0.5	0.7	0.5	0.6	0.1	1.7
Migraine (self-reported)	1.2	1.4	4.7	-1.3	-0.5	0.8	2.2	0.6	0.7	0.8	1.4	1.0	1.6
Medication: Ibuprofen	2.1	2.6	6.4	-0.7	2.0	2.5	2.1	0.8	1.5	0.8	2.5	0.5	0.4
Medication: Allopurinol	0.2	0.3	1.8	-0.2	-0.3	0.6	0.3	-0.0	-0.4	-0.8	0.0	-1.4	0.3
Medication: Omeprazole	0.2	0.2	0.9	-0.3	0.4	-0.1	-0.3	-0.3	0.1	-0.9	-0.5	-0.7	0.1
Medication: Seretide 50 evohaler	1.5	1.7	3.0	-0.7	1.7	1.5	1.5	1.0	1.7	0.8	1.2	1.2	1.4
Mean time to correctly identify matches	0.7	1.4	5.6	0.7	0.2	-2.4	-2.0	0.7	-0.4	1.5	-0.6	0.6	0.3
Heart disease (mother)	1.1	1.3	3.2	-0.4	-0.1	-1.2	-0.7	-1.6	-1.1	-0.7	-1.8	-1.6	-1.1
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.2	0.2	1.1	-1.0	0.3	0.2	-0.2	0.1	0.3	0.4	0.3	0.7	0.3
Whole body fat mass	0.1	0.5	1.4	0.4	-0.7	-1.0	-1.2	-0.4	-0.9	-0.3	-0.0	0.3	-0.3
Leg fat mass (right)	0.1	0.3	0.9	0.0	-0.7	-0.8	-0.7	-0.1	-0.9	-0.4	0.5	0.6	0.2
Arm predicted mass (right)	0.4	1.8	4.2	1.9	-2.0	-1.9	-0.9	1.2	-0.0	1.3	-1.1	1.4	-0.2
Pulse rate, automated reading	0.5	1.6	5.7	0.4	-1.3	-0.7	-0.6	-0.8	-1.4	-0.9	-0.8	-2.4	1.8
Alcohol intake frequency.	0.7	1.5	3.7	0.1	-1.4	-1.0	-0.3	1.7	0.7	1.8	-0.1	1.9	1.4
Comparative height size at age 10	3.1	16.9	31.8	1.7	-5.3	-5.3	-4.8	-3.4	-3.9	-1.8	-5.6	-3.5	-3.7
Number of full sisters	1.0	1.2	3.4	0.0	-0.5	-1.0	-0.8	-1.3	-1.0	-1.1	-1.4	-1.8	-0.8
Suffer from ‘nerves’	0.2	0.4	1.5	-0.4	0.5	-0.7	-0.4	0.2	-0.1	0.7	0.7	-0.2	1.2
Overall health rating	0.2	0.4	2.2	1.0	0.5	0.1	-0.2	0.1	0.4	0.1	0.7	0.2	1.5
Chest pain or discomfort	0.4	0.6	2.4	-0.0	0.4	-0.8	0.1	0.5	0.7	0.8	0.3	1.3	-1.6
Had major operations	0.7	0.9	2.9	0.1	-1.4	1.3	0.4	0.8	-0.5	0.6	-0.4	-1.7	-0.7
Age at last live birth	0.8	1.1	2.9	-1.6	-0.0	1.7	1.4	0.0	0.1	-0.0	1.3	-0.8	1.0
Family relationship satisfaction	1.7	2.1	4.3	0.7	2.0	0.9	1.1	1.8	1.8	1.7	0.4	0.4	2.1
Leg pain on walking	0.5	0.7	3.6	1.9	-0.3	-0.1	-0.5	0.2	0.7	0.4	0.7	1.2	0.3
Qualifications: NVQ or HND or HNC or equivalent	1.3	1.5	4.8	-0.4	2.2	1.6	1.0	0.9	1.7	0.5	1.2	1.0	0.4
Commuting to job workplace: Car/motor vehicle	0.9	1.0	1.9	-1.1	-0.0	0.6	1.1	1.3	0.8	1.0	0.9	1.4	0.9
Illness, injury, bereavement, stress in last 2 years	0.8	1.0	3.0	0.4	-0.7	-1.2	-1.7	-0.4	-0.9	0.1	-1.2	-1.3	-0.5
Medication: Aspirin	0.6	0.8	2.2	1.5	-1.3	-1.3	-1.0	-0.1	-0.2	0.0	-1.1	0.4	0.6
Supplements: Vitamin C	1.0	1.2	3.5	0.6	-0.6	-1.9	-1.6	-0.5	-0.5	0.3	-1.6	0.0	-1.3
Knee pain experienced in last month	0.6	0.9	3.8	1.5	-0.1	0.3	0.0	1.0	0.8	0.1	0.6	2.0	1.0
Hypertension (Self-reported)	1.0	2.7	6.6	0.1	2.6	1.5	2.4	1.8	1.2	0.7	1.8	0.3	1.9
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.6	0.7	2.1	0.9	1.0	1.3	0.7	0.8	1.4	0.5	0.5	0.4	-0.2
Illnesses of father: Heart disease	1.2	1.6	5.4	1.8	-0.0	-1.0	-0.6	1.4	0.4	2.3	-0.7	1.7	-0.3
Illnesses of siblings: Diabetes	1.1	1.4	4.4	1.6	-0.8	-1.7	-2.1	-0.7	-0.7	-0.4	-1.3	0.3	0.2
Smoking status: Previous	0.8	1.2	2.9	0.9	0.4	1.1	0.7	1.3	1.7	1.4	0.4	1.4	0.1
Forced expiratory volume in 1-second (FEV1), predicted	0.2	0.4	0.8	0.4	-0.9	0.4	0.7	-0.3	-0.6	-0.8	-0.1	-0.9	-0.6
Whole body fat-free mass	0.3	2.0	4.7	2.2	-2.0	-2.0	-1.1	1.2	-0.2	1.3	-1.2	1.1	-0.4
Leg fat-free mass (right)	0.3	1.5	5.5	2.4	-1.6	-1.5	-0.8	0.9	0.1	1.2	-1.1	0.8	-0.5
Arm fat percentage (left)	0.0	0.2	1.1	-0.2	0.0	0.4	-0.1	-0.2	-0.4	-0.4	1.0	0.4	0.2
Average weekly red wine intake	0.3	0.4	3.2	1.8	0.2	-0.3	-0.1	0.0	0.3	-0.5	-0.5	-0.5	-0.3
Handedness (chirality/laterality): Left-handed	0.8	1.0	4.7	0.2	0.8	-0.1	0.0	1.4	0.4	1.4	0.6	2.2	0.2
Mood swings	0.5	0.9	2.7	0.5	-1.5	0.2	-0.2	-0.9	-0.9	-1.6	-0.0	-1.3	0.6
Loneliness, isolation	0.7	0.9	3.9	-1.0	-0.2	-0.5	0.7	-0.4	-1.1	-2.0	-0.3	-1.4	-0.1
Long-standing illness, disability or infirmity	0.1	0.2	0.6	0.5	0.5	0.6	0.4	-0.1	0.6	0.1	-0.4	-0.3	0.8
Ever had bowel cancer screening	0.9	1.0	2.9	-0.2	-0.0	-0.9	-1.5	-1.3	-1.7	-1.1	-0.5	-0.9	-0.2
Diabetes diagnosed by doctor	0.8	1.3	4.7	2.2	-1.8	-0.9	-0.5	0.5	-0.0	0.3	-1.0	1.3	-1.3
Ever had stillbirth, spontaneous miscarriage or termination	1.0	1.1	3.1	-1.5	1.8	0.8	0.6	0.5	0.8	1.2	1.3	-0.0	-0.0
Friendships satisfaction	0.9	1.1	3.5	-0.9	1.2	1.0	1.2	0.7	0.9	0.3	1.1	0.0	1.9
Qualifications: nursing, teaching	0.7	1.1	2.4	-1.5	-0.5	-1.2	-0.9	-1.3	-0.9	-0.5	-0.9	-0.9	-1.2
Commuting to job workplace: Walk	0.3	0.3	1.2	-0.8	-0.2	0.3	0.6	0.5	-0.0	-0.1	-0.3	-1.1	-0.6
Eye problems/disorders: Cataract	1.4	1.6	3.5	1.1	-1.8	-0.2	-1.2	-0.5	-1.6	-0.5	-1.5	-1.9	-1.0
Mouth/teeth dental problems: Mouth ulcers	0.7	1.1	2.0	0.0	-0.7	-0.7	-1.4	-1.4	-1.0	-1.0	-1.4	-1.4	-0.6
Medication for cholesterol	0.4	0.6	2.0	0.1	-0.7	-0.6	-0.9	-1.0	-0.1	-0.3	-1.4	-0.7	-1.0
Medication: Laxatives (e.g. Dulcolax, Senokot)	2.2	2.6	8.6	1.2	0.9	1.2	1.2	1.8	2.9	2.2	0.5	1.0	1.8
Back pain experienced in last month	0.7	1.0	3.7	-0.7	-0.6	1.4	1.9	1.0	0.5	-0.4	1.0	1.0	0.1
Mineral and other dietary supplements	0.4	0.6	2.4	-1.2	-0.2	0.6	1.5	0.7	-0.1	-0.3	0.4	-0.8	0.3
Breast cancer (self-reported)	0.5	0.6	2.0	-1.4	1.4	0.1	-0.1	0.9	0.2	0.8	0.7	-0.1	0.5
Asthma (self-reported)	0.4	0.8	1.5	1.0	1.0	-1.0	-1.0	0.3	0.5	0.2	0.5	1.2	-1.2
Osteoporosis (self-reported)	0.7	0.9	2.8	0.8	-0.2	-0.2	-1.6	0.6	0.5	1.7	-0.4	0.9	1.0
Osteoarthritis (self-reported)	0.4	0.5	1.3	0.2	0.1	-0.5	-1.1	-0.4	-1.1	-0.4	0.7	-1.0	0.6
Medication: Aspirin	0.6	0.7	2.7	1.0	-1.6	-1.1	-0.9	-0.5	-0.7	-0.4	-0.8	-0.0	0.5
Medication: Gliclazide	0.8	0.9	4.7	0.4	-2.2	-0.4	0.2	-0.6	-1.1	-1.4	0.0	0.3	-0.1
Illnesses of father: None of the above (group 1)	1.2	1.5	3.9	-1.0	-0.4	1.4	1.4	-0.0	0.3	-1.2	1.8	-0.9	2.0
Smoking status: Current	0.6	1.0	3.3	-0.9	0.9	-0.0	-0.0	-1.4	-0.4	-1.8	1.2	0.1	1.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.7	1.6	4.7	-1.1	0.0	1.5	1.4	0.7	1.1	1.3	1.5	-0.5	2.2
Whole body water mass	0.3	1.9	4.7	2.2	-2.0	-1.9	-1.0	1.2	-0.1	1.4	-1.1	1.2	-0.3
Leg predicted mass (right)	0.3	1.5	5.3	2.3	-1.6	-1.5	-0.7	0.9	0.0	1.2	-1.0	0.8	-0.5
Arm fat mass (left)	0.1	0.3	0.9	0.6	-0.9	-0.7	-0.8	-0.0	-0.7	0.0	-0.1	0.5	-0.3
Number of self-reported non-cancer illnesses	0.6	1.1	2.6	0.6	1.6	1.4	1.2	0.8	1.1	0.5	1.4	0.5	0.7
Average weekly champagne plus white wine intake	0.8	1.1	3.1	0.9	1.6	-1.1	-0.4	0.5	0.6	1.5	0.4	1.8	0.2
Miserableness	0.4	0.6	2.3	0.1	-1.5	0.8	1.0	-0.3	-0.4	-1.3	0.3	-0.4	0.6
Guilty feelings	0.2	0.3	1.9	0.2	0.2	-0.3	0.6	-0.1	0.3	0.2	-0.5	-0.4	-1.4
Wears glasses or contact lenses	1.5	1.8	4.9	-0.0	-2.0	-2.2	-1.6	-1.0	-1.3	-1.2	-1.3	-0.6	-0.3
Ever taken oral contraceptive pill	0.3	0.3	1.9	0.3	-0.1	-0.3	-0.1	0.0	0.5	0.2	-0.4	0.9	-1.4
Hearing aid user	0.9	1.0	5.0	0.2	-0.0	-1.1	-1.0	1.5	0.4	2.2	-0.8	-0.0	-0.3
Mother’s age at death	2.5	3.2	6.0	-0.6	-1.1	-2.4	-1.9	-1.4	-2.5	-1.4	-2.3	-0.9	-2.2
Financial situation satisfaction	1.3	1.6	4.9	-1.7	0.8	1.4	1.8	-0.2	0.6	-0.9	0.9	-0.9	2.2
Tinnitus: Yes, now most or all of the time	1.1	1.3	4.8	-0.3	2.2	0.2	-0.2	-0.1	1.1	0.6	1.8	1.6	-0.1
Commuting to job workplace: Public transport	0.6	0.7	1.7	-0.3	-0.7	-0.5	-0.3	-1.2	-1.1	-0.8	-0.5	-1.3	-1.0
Eye problems/disorders: Glaucoma	1.5	1.8	4.4	1.8	-1.1	-2.0	-1.6	0.1	-1.1	0.5	-2.1	0.1	-1.3
Medication: Blood pressure	0.7	1.3	3.7	0.0	1.1	0.4	1.3	1.9	0.8	0.9	0.9	1.0	1.5
Pain type(s) experienced in last month: Hip pain	0.4	0.5	1.6	-0.6	-0.2	-0.9	-1.2	-1.0	-0.5	-0.2	0.8	-0.4	0.1
Supplements: Fish oil (including cod liver oil)	1.0	1.3	4.1	1.7	0.8	-1.2	-2.0	-0.1	0.1	1.0	-0.6	1.4	-0.4
High cholesterol (Self-reported)	0.9	1.5	5.0	-0.2	-1.1	-0.6	0.4	-2.2	-1.3	-1.8	-0.2	-1.6	0.8
Medication: Bendroflumethiazide	0.1	0.2	0.6	-0.2	0.7	0.2	0.8	-0.1	-0.5	-0.5	0.5	0.0	0.4
Medication: Paracetamol	0.2	0.3	1.3	-0.3	-0.0	0.5	-0.4	0.3	-0.6	0.4	0.1	-1.1	-0.7
Medication: Lisinopril	1.0	1.3	3.1	0.6	0.8	0.7	1.3	1.1	1.0	-0.5	1.1	1.6	1.8
Medication: Atorvastatin	0.2	0.3	0.7	-0.1	-0.3	-0.1	0.3	-0.8	-0.4	-0.8	0.9	0.2	0.8
Illnesses of father: High blood pressure	1.2	1.5	2.7	-0.4	0.1	-0.7	-1.3	-1.6	-1.6	-1.1	-1.3	-1.3	-1.6
Alcohol drinker status: Never	1.0	1.1	3.7	1.4	-0.4	-1.3	-0.7	1.9	0.1	1.3	-0.8	0.9	-0.4
Ever smoked	0.1	0.1	0.3	-0.0	-0.2	-0.3	-0.6	-0.2	-0.1	-0.0	-0.1	0.6	-0.4
Basal metabolic rate	0.3	1.6	3.9	2.0	-1.9	-1.8	-1.0	0.9	-0.3	1.1	-1.0	0.9	-0.4
Leg fat percentage (left)	0.2	0.6	1.9	-0.6	0.0	-0.4	-0.7	-0.4	-1.0	-0.7	1.4	1.1	0.1
Arm fat-free mass (left)	0.4	2.3	5.7	1.9	-2.4	-2.4	-1.4	1.0	-0.5	1.1	-1.3	1.2	-0.7
Number of operations (self-reported)	0.5	0.8	2.9	0.8	-0.1	1.2	0.1	1.7	0.9	0.9	0.7	0.7	0.5
Average weekly beer plus cider intake	1.7	2.5	6.9	0.2	1.1	2.6	2.1	1.5	1.7	0.7	1.3	1.3	1.9
Irritability	0.2	0.3	1.4	0.1	-1.1	-0.1	-0.4	0.1	-0.6	0.5	0.0	0.0	-1.2
Risk taking	0.7	1.0	2.5	0.7	1.5	0.8	0.5	-1.4	0.7	-1.6	0.6	-0.2	1.0
Ever had prostate specific antigen (PSA) test	1.1	1.2	3.8	0.4	-0.2	-1.5	-1.0	-0.9	-1.9	-1.0	-0.3	-1.5	-1.1
Fractured/broken bones in last 5 years	0.6	0.8	2.0	0.9	-1.4	-0.0	-0.5	0.8	-0.7	0.9	-1.3	-0.5	-1.0
Age started oral contraceptive pill	2.4	3.0	9.0	1.3	-2.0	-2.7	-3.0	-0.6	-0.9	0.8	-2.2	0.7	-1.2
Diastolic blood pressure, automated reading	0.2	0.5	2.2	-0.7	-0.3	-1.0	0.0	-0.2	-0.9	-0.6	-0.4	-1.5	0.1
Ever depressed for a whole week	0.3	0.4	1.1	-0.8	0.5	0.1	1.0	0.7	0.3	0.6	0.3	-0.0	1.0
Unable to work because of sickness or disability	0.1	0.2	0.3	-0.3	-0.4	-0.2	-0.6	-0.5	-0.5	-0.0	0.6	-0.5	0.2
Commuting to job workplace: Cycle	0.3	0.4	1.1	0.2	0.3	-0.0	-0.8	-0.5	-0.5	-0.2	-1.0	-0.8	-1.1
Myopia	0.4	0.6	1.4	0.9	1.2	1.0	0.6	0.4	1.0	0.2	0.8	0.4	-0.2
Vascular/heart problems diagnosed by doctor	0.7	2.0	4.4	0.4	-1.9	-1.1	-2.0	-1.2	-1.2	-0.4	-1.8	-0.5	-2.1
Cholesterol lowering medication	0.6	0.8	2.1	0.1	-0.6	-0.7	-0.7	-1.3	-1.2	-1.5	-0.2	-1.2	0.1
Medication: Omeprazole (e.g. Zanprol)	0.3	0.4	1.0	-0.2	-0.1	-0.2	-0.6	-0.8	-0.3	-1.0	-0.7	-0.9	-0.6
Pain experienced in last month	0.2	0.3	1.2	0.2	0.4	0.5	0.6	0.9	0.1	1.1	-0.6	-0.4	0.1
Supplements: Calcium	0.7	0.7	2.9	0.6	-0.5	-1.2	-1.7	-0.2	-0.1	0.6	-1.2	0.1	-0.8
Basal cell carcinoma (self-reported)	2.4	2.8	6.0	-0.0	2.0	1.0	2.5	1.6	2.2	0.8	1.7	2.4	0.4
Heart attack/myocardial infarction (self-reported)	0.5	0.7	2.4	0.1	-1.5	-0.1	-0.8	-1.1	-0.4	-1.1	-0.3	-0.9	-0.4
Deep venous thrombosis (DVT) (self-reported)	0.5	0.6	1.7	0.3	1.0	0.3	-0.5	-0.9	-0.8	-1.3	-0.2	-1.2	0.2
Heart disease (siblings)	1.0	1.2	3.0	0.8	-1.7	-0.7	-1.3	-1.5	-1.1	-1.1	-1.1	-0.5	-0.5
Alcohol drinker status: Previous	0.7	0.8	2.0	0.5	-1.0	1.1	0.4	1.4	1.0	1.2	0.4	0.7	0.7
Pack years of smoking	0.5	0.8	2.2	-0.7	0.3	0.9	1.3	1.2	0.2	-0.2	1.5	0.4	0.7
Impedance of whole body	0.4	2.0	3.5	-1.6	1.9	1.5	0.6	-1.5	-0.1	-1.4	1.5	-1.9	1.1
Leg fat mass (left)	0.1	0.3	0.9	0.1	-0.5	-0.8	-0.7	-0.0	-0.7	-0.2	0.7	1.0	0.2
Arm predicted mass (left)	0.5	2.3	5.8	2.0	-2.3	-2.4	-1.5	0.7	-0.5	1.0	-1.4	1.2	-0.7