Best TWAS P=1.54e-08 · Best GWAS P=1.95e-07 conditioned to 0.0199
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | GTEx | Adrenal Gland | NUCKS1 | 0.17 | 0.00 | enet | 11 | 0.02 | 6.7e-02 | -4.7 | 5.7 | 1.5e-08 | 0.59 | 0.03 | 0.59 | TRUE |
| 2 | GTEx | Brain Cerebellum | SLC41A1 | 0.27 | 0.09 | lasso | 4 | 0.08 | 2.1e-03 | -4.7 | -5.3 | 9.9e-08 | -0.70 | 0.03 | 0.66 | FALSE |
| 3 | GTEx | Heart Atrial Appendage | NUCKS1 | 0.12 | 0.14 | enet | 4 | 0.08 | 1.7e-04 | 5.1 | 5.3 | 1.1e-07 | 0.98 | 0.00 | 0.98 | FALSE |
| 4 | GTEx | Thyroid | NUCKS1 | 0.26 | 0.16 | lasso | 6 | 0.19 | 1.8e-14 | -4.8 | 5.2 | 1.8e-07 | 0.90 | 0.02 | 0.97 | FALSE |
| 5 | YFS | Blood | NUCKS1 | 0.15 | 0.24 | lasso | 4 | 0.25 | 1.4e-80 | -4.8 | 5.1 | 3.0e-07 | 0.89 | 0.02 | 0.97 | FALSE |
| 6 | The Cancer Genome Atlas | Brain Lower Grade Glioma | RAB7L1 | 0.09 | 0.08 | lasso | 2 | 0.07 | 1.1e-08 | 5.2 | -5.2 | 2.4e-07 | -1.00 | 0.00 | 1.00 | FALSE |
| 7 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | RAB7L1 | 0.17 | 0.13 | lasso | 2 | 0.11 | 4.4e-05 | 5.1 | -5.2 | 2.5e-07 | -1.00 | 0.00 | 0.98 | FALSE |