Best TWAS P=1.05e-16 · Best GWAS P=1.43e-18 conditioned to 0.000319
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | ADAM17 | 0.14 | 0.08 | enet | 17 | 0.13 | 2.2e-15 | -7.8 | 6.7 | 1.6e-11 | 0.34 | 0.78 | 0.22 | FALSE |
| 2 | GTEx | Brain Frontal Cortex BA9 | ADAM17 | 0.20 | 0.14 | lasso | 5 | 0.15 | 7.8e-05 | -7.8 | 7.8 | 9.2e-15 | 0.68 | 0.41 | 0.22 | FALSE |
| 3 | GTEx | Cells Transformed fibroblasts | IAH1 | 0.09 | 0.10 | lasso | 4 | 0.07 | 3.7e-06 | -7.3 | -7.5 | 7.9e-14 | -0.60 | 0.28 | 0.70 | FALSE |
| 4 | GTEx | Esophagus Muscularis | RP11-400L8.2 | 0.10 | 0.04 | lasso | 6 | 0.02 | 1.6e-02 | -6.6 | 6.5 | 1.2e-10 | 0.64 | 0.04 | 0.82 | FALSE |
| 5 | GTEx | Muscle Skeletal | ADAM17 | 0.07 | 0.07 | enet | 5 | 0.05 | 4.5e-06 | -7.9 | -7.4 | 1.8e-13 | -0.56 | 0.71 | 0.28 | FALSE |
| 6 | GTEx | Muscle Skeletal | RP11-400L8.2 | 0.11 | 0.11 | lasso | 7 | 0.11 | 7.9e-11 | -7.3 | 7.3 | 2.8e-13 | 0.58 | 1.00 | 0.00 | FALSE |
| 7 | GTEx | Nerve Tibial | ADAM17 | 0.10 | 0.02 | enet | 8 | 0.01 | 3.9e-02 | -7.3 | 7.5 | 7.6e-14 | 0.58 | 0.60 | 0.06 | FALSE |
| 8 | GTEx | Skin Sun Exposed Lower leg | CPSF3 | 0.09 | 0.07 | lasso | 3 | 0.06 | 7.2e-06 | -6.3 | -6.4 | 1.4e-10 | -0.54 | 0.94 | 0.06 | FALSE |
| 9 | GTEx | Testis | ITGB1BP1 | 0.27 | 0.22 | lasso | 3 | 0.21 | 7.5e-10 | -6.3 | -6.5 | 8.0e-11 | -0.56 | 0.93 | 0.06 | FALSE |
| 10 | GTEx | Testis | CPSF3 | 0.17 | 0.03 | enet | 11 | 0.05 | 4.2e-03 | -6.6 | -6.9 | 5.7e-12 | -0.71 | 0.05 | 0.85 | FALSE |
| 11 | GTEx | Testis | IAH1 | 0.30 | 0.07 | lasso | 6 | 0.09 | 5.8e-05 | -7.2 | -7.3 | 2.1e-13 | -0.63 | 0.10 | 0.84 | FALSE |
| 12 | NTR | Blood | ADAM17 | 0.03 | 0.03 | lasso | 8 | 0.03 | 2.1e-09 | -7.2 | 7.2 | 7.1e-13 | 0.57 | 1.00 | 0.00 | FALSE |
| 13 | NTR | Blood | IAH1 | 0.03 | 0.03 | lasso | 10 | 0.04 | 8.8e-12 | -7.4 | 7.5 | 8.0e-14 | 0.62 | 0.99 | 0.01 | FALSE |
| 14 | ROSMAP | Brain Pre-frontal Cortex | IAH1 | 0.08 | 0.07 | lasso | 5 | 0.07 | 8.8e-09 | -7.3 | -6.2 | 4.6e-10 | -0.50 | 1.00 | 0.00 | FALSE |
| 15 | The Cancer Genome Atlas | Breast Invasive Carcinoma | ADAM17 | 0.03 | 0.02 | blup | 41 | 0.03 | 1.8e-06 | -7.0 | -7.7 | 1.2e-14 | -0.73 | 0.06 | 0.93 | FALSE |
| 16 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | IAH1 | 0.03 | 0.01 | blup | 35 | 0.02 | 1.7e-03 | -7.3 | -8.3 | 1.1e-16 | -0.80 | 0.04 | 0.68 | TRUE |
| 17 | The Cancer Genome Atlas | Lung Adenocarcinoma | ADAM17 | 0.03 | 0.01 | blup | 41 | 0.02 | 4.7e-03 | -7.2 | -5.8 | 5.5e-09 | -0.41 | 0.09 | 0.06 | FALSE |
| 18 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | ITGB1BP1 | 0.17 | -0.01 | blup | 32 | 0.09 | 1.9e-04 | -2.5 | -6.9 | 4.0e-12 | -0.81 | 0.01 | 0.27 | FALSE |
| 19 | The Cancer Genome Atlas | Testicular Germ Cell Tumors | ADAM17 | 0.10 | 0.14 | lasso | 2 | 0.13 | 3.2e-05 | -7.8 | -7.9 | 3.0e-15 | -0.54 | 0.42 | 0.25 | FALSE |