[Hub]/) : Traits : Birth weight :

chr2:8,850,817-10,394,558

Best TWAS P=1.05e-16 · Best GWAS P=1.43e-18 conditioned to 0.000319

Associated models

# Study Tissue Gene h2 eQTL R2 model # weights model R2 model R2 P eQTL GWAS Z TWAS Z TWAS P Top SNP corr PP3 PP4 joint
1 CommonMind Brain Pre-frontal Cortex ADAM17 0.14 0.08 enet 17 0.13 2.2e-15 -7.8 6.7 1.6e-11 0.34 0.78 0.22 FALSE
2 GTEx Brain Frontal Cortex BA9 ADAM17 0.20 0.14 lasso 5 0.15 7.8e-05 -7.8 7.8 9.2e-15 0.68 0.41 0.22 FALSE
3 GTEx Cells Transformed fibroblasts IAH1 0.09 0.10 lasso 4 0.07 3.7e-06 -7.3 -7.5 7.9e-14 -0.60 0.28 0.70 FALSE
4 GTEx Esophagus Muscularis RP11-400L8.2 0.10 0.04 lasso 6 0.02 1.6e-02 -6.6 6.5 1.2e-10 0.64 0.04 0.82 FALSE
5 GTEx Muscle Skeletal ADAM17 0.07 0.07 enet 5 0.05 4.5e-06 -7.9 -7.4 1.8e-13 -0.56 0.71 0.28 FALSE
6 GTEx Muscle Skeletal RP11-400L8.2 0.11 0.11 lasso 7 0.11 7.9e-11 -7.3 7.3 2.8e-13 0.58 1.00 0.00 FALSE
7 GTEx Nerve Tibial ADAM17 0.10 0.02 enet 8 0.01 3.9e-02 -7.3 7.5 7.6e-14 0.58 0.60 0.06 FALSE
8 GTEx Skin Sun Exposed Lower leg CPSF3 0.09 0.07 lasso 3 0.06 7.2e-06 -6.3 -6.4 1.4e-10 -0.54 0.94 0.06 FALSE
9 GTEx Testis ITGB1BP1 0.27 0.22 lasso 3 0.21 7.5e-10 -6.3 -6.5 8.0e-11 -0.56 0.93 0.06 FALSE
10 GTEx Testis CPSF3 0.17 0.03 enet 11 0.05 4.2e-03 -6.6 -6.9 5.7e-12 -0.71 0.05 0.85 FALSE
11 GTEx Testis IAH1 0.30 0.07 lasso 6 0.09 5.8e-05 -7.2 -7.3 2.1e-13 -0.63 0.10 0.84 FALSE
12 NTR Blood ADAM17 0.03 0.03 lasso 8 0.03 2.1e-09 -7.2 7.2 7.1e-13 0.57 1.00 0.00 FALSE
13 NTR Blood IAH1 0.03 0.03 lasso 10 0.04 8.8e-12 -7.4 7.5 8.0e-14 0.62 0.99 0.01 FALSE
14 ROSMAP Brain Pre-frontal Cortex IAH1 0.08 0.07 lasso 5 0.07 8.8e-09 -7.3 -6.2 4.6e-10 -0.50 1.00 0.00 FALSE
15 The Cancer Genome Atlas Breast Invasive Carcinoma ADAM17 0.03 0.02 blup 41 0.03 1.8e-06 -7.0 -7.7 1.2e-14 -0.73 0.06 0.93 FALSE
16 The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma IAH1 0.03 0.01 blup 35 0.02 1.7e-03 -7.3 -8.3 1.1e-16 -0.80 0.04 0.68 TRUE
17 The Cancer Genome Atlas Lung Adenocarcinoma ADAM17 0.03 0.01 blup 41 0.02 4.7e-03 -7.2 -5.8 5.5e-09 -0.41 0.09 0.06 FALSE
18 The Cancer Genome Atlas Pheochromocytoma and Paraganglioma ITGB1BP1 0.17 -0.01 blup 32 0.09 1.9e-04 -2.5 -6.9 4.0e-12 -0.81 0.01 0.27 FALSE
19 The Cancer Genome Atlas Testicular Germ Cell Tumors ADAM17 0.10 0.14 lasso 2 0.13 3.2e-05 -7.8 -7.9 3.0e-15 -0.54 0.42 0.25 FALSE