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chr2:8,850,817-10,394,558

Best TWAS P=1.05e-16 · Best GWAS P=1.43e-18 conditioned to 0.000319

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
16	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	IAH1	0.03	0.01	blup	35	0.02	1.7e-03	-7.3	-8.3	1.1e-16	-0.80	0.04	0.68	TRUE
19	The Cancer Genome Atlas	Testicular Germ Cell Tumors	ADAM17	0.10	0.14	lasso	2	0.13	3.2e-05	-7.8	-7.9	3.0e-15	-0.54	0.42	0.25	FALSE
2	GTEx	Brain Frontal Cortex BA9	ADAM17	0.20	0.14	lasso	5	0.15	7.8e-05	-7.8	7.8	9.2e-15	0.68	0.41	0.22	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	ADAM17	0.03	0.02	blup	41	0.03	1.8e-06	-7.0	-7.7	1.2e-14	-0.73	0.06	0.93	FALSE
7	GTEx	Nerve Tibial	ADAM17	0.10	0.02	enet	8	0.01	3.9e-02	-7.3	7.5	7.6e-14	0.58	0.60	0.06	FALSE
3	GTEx	Cells Transformed fibroblasts	IAH1	0.09	0.10	lasso	4	0.07	3.7e-06	-7.3	-7.5	7.9e-14	-0.60	0.28	0.70	FALSE
13	NTR	Blood	IAH1	0.03	0.03	lasso	10	0.04	8.8e-12	-7.4	7.5	8.0e-14	0.62	0.99	0.01	FALSE
5	GTEx	Muscle Skeletal	ADAM17	0.07	0.07	enet	5	0.05	4.5e-06	-7.9	-7.4	1.8e-13	-0.56	0.71	0.28	FALSE
11	GTEx	Testis	IAH1	0.30	0.07	lasso	6	0.09	5.8e-05	-7.2	-7.3	2.1e-13	-0.63	0.10	0.84	FALSE
6	GTEx	Muscle Skeletal	RP11-400L8.2	0.11	0.11	lasso	7	0.11	7.9e-11	-7.3	7.3	2.8e-13	0.58	1.00	0.00	FALSE
12	NTR	Blood	ADAM17	0.03	0.03	lasso	8	0.03	2.1e-09	-7.2	7.2	7.1e-13	0.57	1.00	0.00	FALSE
18	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	ITGB1BP1	0.17	-0.01	blup	32	0.09	1.9e-04	-2.5	-6.9	4.0e-12	-0.81	0.01	0.27	FALSE
10	GTEx	Testis	CPSF3	0.17	0.03	enet	11	0.05	4.2e-03	-6.6	-6.9	5.7e-12	-0.71	0.05	0.85	FALSE
1	CommonMind	Brain Pre-frontal Cortex	ADAM17	0.14	0.08	enet	17	0.13	2.2e-15	-7.8	6.7	1.6e-11	0.34	0.78	0.22	FALSE
9	GTEx	Testis	ITGB1BP1	0.27	0.22	lasso	3	0.21	7.5e-10	-6.3	-6.5	8.0e-11	-0.56	0.93	0.06	FALSE
4	GTEx	Esophagus Muscularis	RP11-400L8.2	0.10	0.04	lasso	6	0.02	1.6e-02	-6.6	6.5	1.2e-10	0.64	0.04	0.82	FALSE
8	GTEx	Skin Sun Exposed Lower leg	CPSF3	0.09	0.07	lasso	3	0.06	7.2e-06	-6.3	-6.4	1.4e-10	-0.54	0.94	0.06	FALSE
14	ROSMAP	Brain Pre-frontal Cortex	IAH1	0.08	0.07	lasso	5	0.07	8.8e-09	-7.3	-6.2	4.6e-10	-0.50	1.00	0.00	FALSE
17	The Cancer Genome Atlas	Lung Adenocarcinoma	ADAM17	0.03	0.01	blup	41	0.02	4.7e-03	-7.2	-5.8	5.5e-09	-0.41	0.09	0.06	FALSE