Best TWAS P=1.4e-10 · Best GWAS P=2.13e-11 conditioned to 0.00611
# | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
1 | GTEx | Artery Aorta | RP11-173M1.8 | 0.58 | 0.18 | enet | 19 | 0.39 | 1.5e-22 | 2.2 | 5.2 | 2.3e-07 | 0.66 | 0.87 | 0.13 | FALSE |
2 | GTEx | Artery Coronary | RP11-173M1.8 | 0.34 | 0.08 | enet | 17 | 0.21 | 1.1e-07 | 6.7 | 6.4 | 1.6e-10 | 0.73 | 0.01 | 0.98 | FALSE |
3 | GTEx | Cells Transformed fibroblasts | RP11-173M1.8 | 0.33 | 0.10 | lasso | 6 | 0.26 | 1.6e-19 | 2.2 | 5.5 | 3.5e-08 | 0.71 | 0.08 | 0.92 | FALSE |
4 | GTEx | Esophagus Gastroesophageal Junction | RP11-173M1.8 | 0.68 | 0.40 | enet | 8 | 0.43 | 6.6e-17 | 2.2 | 5.7 | 1.2e-08 | 0.66 | 0.98 | 0.02 | FALSE |
5 | GTEx | Esophagus Mucosa | RP11-173M1.8 | 0.35 | 0.07 | enet | 17 | 0.19 | 7.8e-13 | 2.2 | 5.2 | 2.3e-07 | 0.67 | 0.07 | 0.92 | FALSE |
6 | GTEx | Esophagus Muscularis | RP11-173M1.8 | 0.41 | 0.12 | lasso | 6 | 0.28 | 4.0e-17 | 2.2 | 5.9 | 3.5e-09 | 0.74 | 0.03 | 0.97 | FALSE |
7 | GTEx | Nerve Tibial | RP11-173M1.8 | 0.45 | 0.11 | enet | 10 | 0.25 | 4.7e-18 | 2.2 | 5.3 | 9.3e-08 | 0.72 | 0.01 | 0.99 | FALSE |
8 | GTEx | Prostate | RP11-173M1.8 | 0.27 | 0.23 | enet | 14 | 0.19 | 1.6e-05 | 6.3 | 6.4 | 1.4e-10 | 0.77 | 0.03 | 0.93 | TRUE |
9 | GTEx | Stomach | RP11-173M1.8 | 0.32 | 0.09 | enet | 12 | 0.25 | 4.0e-12 | 6.7 | 5.8 | 7.4e-09 | 0.81 | 0.01 | 0.99 | FALSE |
10 | GTEx | Thyroid | WSB1 | 0.07 | 0.00 | enet | 14 | 0.00 | 3.2e-01 | 6.3 | -5.3 | 9.2e-08 | -0.70 | 0.02 | 0.79 | FALSE |
11 | NTR | Blood | WSB1 | 0.06 | 0.01 | lasso | 5 | 0.03 | 6.1e-11 | -1.9 | -5.5 | 4.7e-08 | -0.67 | 0.14 | 0.86 | FALSE |
12 | The Cancer Genome Atlas | Thyroid Carcinoma | WSB1 | 0.05 | 0.05 | enet | 4 | 0.04 | 8.9e-05 | 6.5 | 6.2 | 5.7e-10 | 0.81 | 0.03 | 0.96 | FALSE |