Hub : Genes

WSB1

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Pituitary 0.2110 0.0940 4.0e-03 -0.012 NA 0.050 NA 0.026 9.2e-01 NA 2.2e-02 NA 7.4e-02
2 GTEx Thyroid 0.0670 0.0300 7.1e-03 -0.004 NA 0.000 NA -0.002 9.4e-01 NA 3.2e-01 NA 5.8e-01
3 METSIM Adipose 0.0677 0.0335 2.3e-03 -0.002 0.016 0.017 0.019 0.000 9.8e-01 1.6e-03 1.0e-03 6.4e-04 3.6e-01
4 NTR Blood 0.0555 0.0175 8.7e-08 0.014 0.017 0.028 0.026 0.033 2.2e-05 2.2e-06 1.4e-09 8.2e-09 6.1e-11
5 YFS Blood 0.0605 0.0169 6.2e-11 0.033 0.036 0.040 0.036 0.040 6.3e-11 7.1e-12 3.9e-13 5.5e-12 5.5e-13
6 TCGA Testicular Germ Cell Tumors 0.2380 0.1040 1.2e-03 -0.007 0.033 0.042 NA 0.017 7.1e-01 2.5e-02 1.3e-02 NA 7.9e-02
7 TCGA Thyroid Carcinoma 0.0470 0.0260 3.7e-04 0.045 0.036 0.040 NA 0.038 3.1e-05 2.0e-04 8.9e-05 NA 1.2e-04

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5 6 7
Bipolar Disorder (2018) 0.5 0.9 1.9 -0.3 0.5 0.8 1.4 1.4 0.3 -1.1
Bipolar Disorder or Schizophrenia 0.1 0.2 0.3 0.3 -0.6 -0.4 -0.5 -0.2 -0.5 -0.3
Depressed Affect (Nagel 2018) 0.3 0.6 1.4 0.8 -0.8 -1.2 -0.4 -0.5 0.8 0.3
Depression (Nagel 2018) 0.4 0.6 1.7 0.3 -1.3 -0.6 0.9 0.2 0.9 -0.6
Intelligence (Savage-Jansen 2018) 0.4 1.2 2.2 -0.4 -0.4 -1.4 -1.5 -1.2 0.9 1.3
Neuroticism (Nagel 2018) 0.2 0.4 0.8 0.9 0.0 -0.8 0.2 -0.3 0.9 -0.6
Schizophrenia (2018) 0.6 1.3 3.1 0.7 -1.2 -1.1 -1.8 -1.4 -1.0 0.5
Schizophrenia vs Biploar Disorder 3.6 4.7 10.7 -3.3 -2.2 -2.8 -1.9 -2.2 -0.2 0.9
Worry (Nagel 2018) 0.3 0.7 1.5 0.9 1.1 0.5 0.3 0.4 1.0 -1.2
Alzheimer’s Disease (in mother) 0.6 0.7 3.2 -0.5 0.3 0.9 -0.0 0.6 1.8 -0.4
Alzheimer’s Disease (in father) 1.2 1.3 2.9 1.2 -0.2 0.1 -1.7 -1.4 1.0 1.3
Alzheimer’s Disease (including proxy) 0.6 0.9 2.4 0.4 0.3 0.8 -1.5 -0.5 1.6 0.7
Crohns Disease (2017) 0.6 1.3 3.3 -0.1 1.6 -0.7 -1.5 -0.5 -1.8 -0.2
Irritable Bowel Disease (IBD) 0.1 0.3 0.9 -0.6 1.0 -0.1 -0.3 -0.7 0.1 -0.0
Ulcerative Colitis (UC) 0.3 0.6 2.1 -0.9 -0.2 0.4 0.9 -0.5 1.4 0.1
Major Depression (MDD) 0.8 1.0 2.3 1.5 0.5 0.7 -0.4 0.4 1.3 -1.3
Reaction Time 0.1 0.3 1.0 0.1 0.1 0.2 -0.7 -1.0 -0.5 0.4
Verbal and Numeric Reasoning (VNR) 0.1 0.2 0.5 0.0 -0.4 -0.5 -0.5 -0.1 0.3 0.7
Breast Cancer 0.7 1.6 4.9 1.5 -1.5 2.2 0.6 0.7 0.8 0.6
Ovarian Cancer 0.4 0.5 1.5 1.1 -1.2 0.5 0.8 0.3 -0.0 -0.2
Prostate Cancer 0.4 0.6 1.6 -0.8 -1.3 -0.3 1.2 -0.1 0.5 0.1
Age at First Birth 2.2 3.2 7.3 0.1 -1.1 -1.8 -2.7 -1.6 -1.9 2.1
Bipolar Disorder (2011) 0.9 0.9 1.9 1.0 0.1 0.8 1.4 1.1 0.8 -0.8
Body Mass Index (BMI) (2010) 2.1 2.9 5.2 2.0 1.6 0.7 1.5 2.3 1.3 -2.1
Coronary Artery Disease (CAD) 1.1 1.3 3.9 -1.5 -0.5 -2.0 -0.8 -0.8 -0.2 1.1
Crohns Disease (2012) 0.6 1.0 3.5 0.3 0.7 -0.2 -1.5 -0.1 -1.9 -0.8
Mean Putamen Volume 1.5 1.7 3.3 -1.0 -1.6 -0.8 -0.2 -1.4 1.5 1.8
Fasting Glucose 0.1 0.1 0.3 0.3 0.5 0.4 -0.4 -0.1 -0.5 -0.0
HbA1C 1.1 1.2 2.4 0.7 -1.3 -1.2 -0.9 -1.1 -0.7 1.6
HDL Cholesterol 1.9 3.1 4.5 1.3 1.7 1.9 2.1 1.8 1.6 -1.8
LDL Cholesterol 1.7 2.6 7.6 0.6 1.6 0.7 2.8 1.9 -0.5 -1.9
Lupus 0.4 0.6 1.0 0.9 0.8 -0.9 -1.0 -0.1 0.4 -0.8
Neuroticism (2016) 0.9 1.3 3.1 0.6 1.3 0.5 0.9 1.2 1.3 -1.8
Primary Biliary Cirrhosis 1.1 1.6 5.7 -0.7 -0.4 -0.5 -2.4 -0.2 -1.8 1.1
Rheumatoid Arthritis 0.3 0.4 2.0 -0.6 -0.2 -0.1 -1.4 -0.0 -0.0 0.4
Schizophrenia (2014) 0.7 1.5 3.3 -0.6 -1.3 -1.5 -1.4 -1.8 -0.9 0.2
Triglycerides 0.2 0.4 0.9 -0.4 -0.6 -0.9 0.9 -0.1 -0.2 -0.6
Type 2 Diabetes (T2D) (2012) 0.5 0.6 1.5 -1.2 0.7 0.4 0.0 0.5 0.8 -1.0
Ulcerative Colitis 0.6 0.9 3.1 -1.2 -0.0 1.0 0.5 -0.3 1.8 0.3
Blood Eosinophil Count 0.5 3.8 10.6 3.3 -2.0 2.4 1.0 -0.3 2.2 0.8
Blood Platelet Count 0.1 1.6 3.5 -1.1 -0.3 -1.5 -1.5 -1.9 -0.8 1.2
Blood Red Count 0.2 2.0 6.7 -0.6 -1.0 1.2 -1.5 -0.3 -1.2 2.6
Blood White Count 0.6 4.6 11.5 2.3 -0.1 2.4 3.4 1.2 2.7 -1.0
Heel T-Score 1.9 15.4 25.5 1.6 4.3 3.3 4.3 4.1 3.7 -5.0
BMI 0.2 1.1 4.2 0.3 1.4 -0.9 -0.4 -0.2 0.3 -2.1
Height 0.7 12.7 36.5 0.0 -4.4 -0.7 -4.4 -3.5 -1.1 6.0
Waist Hip Ratio (WHR) 1.1 4.7 11.2 -0.7 -1.0 -3.4 -2.2 -3.0 -1.7 2.0
Systolic Blood Pressure 0.1 0.5 1.1 0.4 0.6 -1.0 -0.6 -0.6 0.2 -0.9
Smoking Status 0.4 0.9 3.9 -0.3 0.7 -0.1 0.5 0.1 1.2 -2.0
Allergy or Eczema 1.4 3.6 8.0 -0.7 -1.9 -1.7 -1.9 -2.8 -1.4 2.2
Cardiovascular Disease 0.4 1.2 6.7 2.6 0.3 -0.8 -0.0 -0.5 0.6 -0.8
Hypothyroidism (self reported) 0.4 0.8 1.5 0.2 1.2 0.6 0.8 0.9 0.9 -1.2
Respiratory disease 1.8 4.0 8.7 -0.2 1.5 0.5 3.0 1.2 2.8 -2.7
Type 2 Diabetes (T2D) (2018) 0.2 0.4 1.2 -0.6 0.5 -1.1 0.6 -0.0 0.7 -0.2
Lung FEV1/FVC ratio 3.0 15.1 20.9 -1.4 -3.7 -4.0 -4.5 -4.6 -4.1 4.1
Lung FVC 0.5 2.6 8.8 3.0 1.2 1.9 1.2 1.5 1.0 -0.2
Neuroticism 0.2 0.5 1.7 1.3 -0.1 -0.1 0.5 0.5 0.8 -0.8
Chronotype (morning person) 1.5 3.5 6.0 0.4 2.3 1.5 2.2 2.4 1.1 -2.3
Hair Pigment 0.1 2.2 7.0 -2.6 1.1 -2.4 -0.1 -1.1 0.3 0.2
Tanning 0.0 0.6 1.1 -0.6 -0.5 0.5 -0.9 0.6 -1.0 0.9
Hand grip strength (left) 0.2 0.6 1.4 0.3 -0.9 1.1 0.2 0.4 1.2 0.4
Number of treatments/medications taken 0.3 0.5 2.1 0.2 -0.1 -0.8 -0.6 -1.4 -0.1 0.7
Average weekly spirits intake 0.2 0.3 1.6 -1.3 0.1 0.2 -0.3 0.1 -0.2 -0.2
Sensitivity / hurt feelings 0.7 1.2 2.0 -0.8 -1.1 -1.4 -1.4 -1.1 -1.0 0.5
Frequency of depressed mood in last 2 weeks 0.2 0.3 0.8 -0.4 -0.3 0.1 0.2 0.4 -0.9 -0.7
Hearing difficulty/problems: Yes 0.9 1.3 3.0 -0.1 1.6 0.8 0.3 1.7 -0.2 -1.7
Relative age of first facial hair 0.1 0.2 0.7 -0.5 -0.1 0.0 -0.8 -0.2 -0.6 0.5
Other serious medical condition/disability diagnosed by doctor 0.4 0.5 1.9 -0.5 0.1 1.4 0.3 0.6 0.8 -0.3
Ever used hormone-replacement therapy (HRT) 0.6 0.8 1.9 1.4 -0.0 -1.2 1.3 -0.1 0.1 -0.0
Ever had hysterectomy (womb removed) 0.5 0.6 1.5 0.7 0.9 -1.2 -0.2 0.1 -1.2 -0.1
Systolic blood pressure, automated reading 0.1 0.2 0.6 0.4 -0.3 0.1 -0.3 -0.5 0.8 0.2
Eye problems/disorders: Diabetes related eye disease 0.7 0.8 2.0 1.1 -0.2 1.1 0.6 1.4 0.6 -0.2
Angina 0.9 1.2 2.3 0.8 1.0 1.5 1.1 1.5 0.8 -0.4
Medication for hormone replacement therapy 1.6 1.8 6.1 -0.4 2.5 0.2 0.9 1.0 0.4 -2.0
Vitamin and mineral supplements 0.3 0.5 2.2 0.9 -0.1 -0.3 -0.0 -0.2 -1.5 -0.1
Supplements: Zinc 1.0 1.0 3.8 -0.4 0.4 -1.9 -1.0 -1.3 0.4 -0.2
Medication: Co-codamol 0.7 0.8 2.4 0.3 0.9 0.1 0.9 0.6 1.0 -1.6
Medication: Metformin 0.2 0.3 0.6 -0.4 0.3 -0.8 0.1 -0.6 -0.4 -0.7
Diabetes (father) 2.4 3.0 6.5 1.5 1.8 2.6 0.8 1.8 1.6 -1.5
Diabetes (mother) 0.7 0.9 2.8 1.7 -0.4 -0.6 -0.8 -0.9 -0.6 1.0
Severe depression (siblings) 0.8 0.9 2.1 -1.0 0.9 0.5 0.8 1.0 1.4 -0.8
Pack years adult smoking proportion 0.6 0.8 2.4 0.8 1.3 0.4 0.3 0.5 -0.8 -1.6
Impedance of leg (right) 0.4 1.7 6.2 0.1 0.3 1.6 1.7 2.5 -0.4 -0.3
Leg fat-free mass (left) 0.4 2.0 5.7 -0.5 -1.0 -1.5 -2.4 -2.1 0.5 0.8
Trunk fat percentage 0.2 0.7 1.0 -0.8 0.8 -1.0 -0.7 -1.0 -0.5 -1.0
Hand grip strength (right) 0.4 1.0 1.9 -0.4 -1.4 1.1 0.9 0.8 1.4 0.2
Townsend deprivation index at recruitment 0.6 0.9 2.4 0.1 1.5 -0.4 0.8 -0.3 0.6 -1.6
Current tobacco smoking 0.5 0.8 1.9 -0.7 0.4 -0.8 -1.2 -0.7 -1.4 -0.7
Average weekly fortified wine intake 1.5 1.8 3.1 -1.5 -1.7 -1.7 -0.7 -1.4 -1.4 0.0
Maternal smoking around birth 1.8 2.6 5.1 0.3 1.3 1.8 2.3 1.8 1.6 -1.4
Fed-up feelings 0.3 0.6 1.8 -0.1 -1.1 -1.4 -0.4 -0.8 -0.0 0.3
Frequency of unenthusiasm / disinterest in last 2 weeks 0.4 0.6 1.2 1.1 -1.1 -0.9 0.7 0.3 -0.0 -0.4
Relative age voice broke 0.7 1.1 5.2 0.5 -0.4 -0.5 -2.3 -0.7 -1.1 0.6
Taking other prescription medications 0.5 0.7 2.2 0.8 0.2 0.4 1.4 -0.0 1.5 -0.0
Age when periods started (menarche) 0.3 0.8 2.8 -0.2 -0.6 -0.4 -1.7 -0.8 -1.2 0.3
Bilateral oophorectomy (both ovaries removed) 0.1 0.1 0.4 0.4 0.1 -0.3 0.1 0.1 -0.6 0.1
Heel bone mineral density (BMD) T-score, automated (left) 0.3 0.8 2.4 -1.3 0.1 0.1 1.0 0.4 1.6 -0.3
Tinnitus: Yes, but not now, but have in the past 1.8 1.9 4.6 -2.1 -0.5 -0.9 -2.1 -1.1 -0.0 1.4
Qualifications: CSEs or equivalent 1.0 1.4 7.8 -0.4 -0.8 0.0 -2.8 -0.7 -0.5 0.5
Serious illness, injury or assault to yourself 0.7 0.8 2.4 -0.3 1.4 0.6 0.2 1.5 -1.0 -0.1
High blood pressure 0.3 0.9 5.4 2.3 0.2 -0.0 0.1 0.1 0.8 -0.5
Hayfever, allergic rhinitis or eczema 1.7 3.7 8.7 -0.6 -1.4 -1.8 -2.0 -3.0 -1.8 2.1
Multivitamins +/- minerals 0.4 0.5 1.2 -0.8 -0.1 -0.6 -1.1 -0.4 0.7 0.6
Stomach or abdominal pain in last month 0.4 0.5 0.8 -0.9 0.6 0.3 0.9 0.9 -0.5 -0.5
Supplements: Glucosamine 2.3 2.9 10.4 3.2 -0.7 -0.9 -1.1 -1.9 0.5 1.9
Diverticular disease/diverticulitis (self-reported) 0.3 0.3 1.5 0.3 1.2 -0.4 -0.6 -0.1 -0.0 -0.3
Medication: Atenolol 0.3 0.4 1.0 -1.0 0.9 0.3 0.0 0.4 -0.1 -0.8
Medication: Levothyroxine sodium 1.1 1.9 3.7 0.6 1.2 1.2 1.1 1.8 1.3 -1.9
Sitting height 0.1 0.6 2.1 -0.3 -1.1 -0.3 -0.7 0.2 0.1 1.5
Chronic bronchitis/emphysema (father) 1.7 2.0 4.7 1.2 1.1 1.1 1.9 1.1 2.2 -0.9
High blood pressure (mother) 0.7 1.0 1.5 -0.2 -1.1 -1.1 -1.2 -1.1 -1.2 0.5
Body mass index (BMI) 0.2 0.8 2.0 -0.1 1.0 -1.1 -0.4 -0.9 0.4 -1.4
Impedance of leg (left) 0.4 2.0 6.7 -0.3 1.0 1.6 1.6 2.6 -0.9 -0.4
Leg predicted mass (left) 0.4 2.0 5.3 -0.6 -1.0 -1.4 -2.3 -2.0 0.5 0.8
Trunk fat mass 0.2 0.9 2.2 -0.8 0.3 -1.3 -1.3 -1.5 -0.3 -0.4
Waist circumference 0.5 1.9 4.9 -0.4 0.4 -2.2 -1.7 -2.2 -0.6 0.2
Number of incorrect matches in round 0.2 0.4 0.8 0.1 0.5 0.2 0.6 0.8 0.9 -0.9
Past tobacco smoking 1.3 2.5 8.6 -0.6 -1.4 -0.5 -1.5 -0.8 -1.8 2.9
Alcohol usually taken with meals 0.4 0.7 3.2 -0.6 0.7 1.8 0.3 0.2 0.6 0.3
Nervous feelings 0.4 0.7 2.1 1.4 0.6 0.8 -0.6 0.8 0.3 -0.9
Frequency of tenseness / restlessness in last 2 weeks 0.4 0.5 2.2 -0.0 0.7 0.5 0.1 1.5 -0.0 -0.9
Hearing difficulty/problems with background noise 0.7 1.2 3.1 -1.0 1.5 -0.3 -1.2 0.5 -0.3 -1.8
Hair/balding pattern: Pattern 2 0.2 0.2 0.6 0.1 -0.6 -0.4 -0.1 -0.2 -0.4 0.8
Had menopause 0.2 0.2 1.0 1.0 0.2 0.0 0.6 0.1 -0.4 0.1
Had other major operations 0.2 0.3 0.9 -0.3 1.0 -0.1 0.3 0.9 0.0 -0.4
Forced vital capacity (FVC) 0.2 0.6 2.0 1.0 -0.7 0.2 -0.5 0.0 0.5 1.4
Heel bone mineral density (BMD) T-score, automated (right) 0.2 0.4 1.2 -1.1 0.2 0.8 0.5 0.3 0.8 -0.1
Ever unenthusiastic/disinterested for a whole week 1.0 1.2 4.3 -0.1 -0.6 -2.1 -1.3 -1.1 -0.9 0.0
Qualifications: None of the above 0.8 1.8 3.3 1.6 1.6 0.1 1.8 0.3 1.5 -1.3
Financial difficulties in last 2 years 2.9 3.9 8.1 0.3 2.7 0.9 1.8 2.3 1.6 -2.8
Mouth/teeth dental problems 0.2 0.4 1.6 -0.3 0.6 -0.5 -0.5 -0.2 -1.3 0.1
Heart attack 0.9 1.1 2.6 -1.2 1.1 -0.5 1.6 0.9 -0.2 -1.2
Allergy 0.2 0.5 2.2 0.2 -0.1 0.9 0.2 1.5 0.1 -0.2
Pain all over the body in last month 1.1 1.2 3.0 0.4 1.4 0.6 0.8 1.0 1.2 -1.7
Diabetes (self-reported) 0.2 0.2 0.6 -0.3 -0.4 -0.7 -0.2 -0.8 -0.4 0.3
Hayfever/allergic rhinitis (self-reported) 0.7 0.9 3.4 -1.4 -0.0 0.6 0.4 -0.6 1.8 -0.1
Medication: Ramipril 0.5 0.7 2.4 0.9 0.6 -0.1 1.5 0.7 -0.1 -0.9
Medication: Simvastatin 1.0 1.5 2.6 -0.1 -1.6 -1.4 -1.2 -1.3 -1.4 1.0
Fluid intelligence score 0.1 0.1 0.6 0.0 -0.0 -0.0 -0.8 -0.4 0.4 -0.1
Illnesses of siblings 6.6 9.3 16.7 -2.3 -2.5 -2.4 -4.1 -2.8 -3.4 3.4
Neuroticism score 0.1 0.3 1.0 0.6 -0.7 -0.3 -0.1 0.3 0.4 -1.0
Weight 0.2 0.9 2.7 -0.4 -0.0 -1.2 -1.6 -1.5 0.4 0.1
Impedance of arm (right) 0.2 1.1 2.6 -0.9 -1.3 -0.5 -0.9 -0.6 -1.6 1.1
Arm fat percentage (right) 0.3 1.3 2.4 -1.0 0.5 -1.4 -1.2 -1.6 -0.6 -1.3
Trunk fat-free mass 0.3 1.6 5.0 0.2 -1.0 -1.0 -2.2 -1.6 0.7 1.0
Hip circumference 0.0 0.2 0.6 -0.0 0.2 -0.3 -0.8 -0.7 0.4 0.1
Time employed in main current job 0.3 0.3 0.6 -0.8 0.5 0.6 -0.1 0.7 0.5 -0.7
Alcohol intake versus 10 years previously 1.2 1.8 7.2 -0.9 -1.2 -2.7 0.4 -1.4 -0.4 0.9
Father’s age at death 0.7 1.0 2.4 -0.2 -0.6 1.2 1.1 1.5 -1.2 -0.1
Worrier / anxious feelings 0.1 0.2 1.0 0.2 0.0 -0.3 -0.2 -0.3 0.4 -1.0
Frequency of tiredness / lethargy in last 2 weeks 0.1 0.2 0.4 -0.3 -0.6 0.2 0.5 0.5 -0.5 -0.1
Falls in the last year 1.5 2.0 4.8 0.5 1.5 1.0 1.1 1.9 1.1 -2.2
Hair/balding pattern: Pattern 3 1.1 1.6 2.9 -0.2 1.4 1.2 1.7 1.1 1.5 -1.2
Number of live births 0.5 0.7 2.6 0.3 1.2 -0.1 0.1 0.2 1.6 -0.7
Forced expiratory volume in 1-second (FEV1) 0.6 2.1 4.7 1.2 -1.2 -0.9 -1.9 -1.2 -1.0 2.2
Pulse rate 0.4 0.6 1.7 -1.3 -0.1 -0.9 -1.0 -0.2 -0.6 -0.7
Happiness 0.8 1.0 1.7 -1.3 -1.2 -0.0 -1.3 -0.9 -0.7 1.0
Noisy workplace 0.3 0.4 0.9 0.7 0.2 0.4 1.0 0.6 0.2 -0.8
Qualifications: A levels/AS levels or equivalent 1.0 2.1 4.2 -1.9 -1.1 0.9 -1.1 -0.5 -2.0 1.9
Serious illness, injury or assault of a close relative in last 2 years 1.2 1.4 5.1 1.2 -0.1 0.9 2.3 1.1 0.9 -0.4
Mouth/teeth dental problems: Dentures 0.2 0.3 1.4 -0.1 -1.2 -0.1 0.5 0.2 0.5 -0.1
Asthma 1.5 2.9 5.7 0.7 1.4 1.2 2.1 1.1 2.4 -2.2
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.3 0.5 0.6 -0.6 0.5 0.3 -0.6 0.7 0.3
Medication: Cholesterol lowering 2.5 3.8 7.0 -0.1 -0.9 -2.3 -2.4 -2.6 -2.6 1.2
Depression (self-reported) 0.8 0.9 2.7 0.4 1.6 0.8 0.8 0.4 -0.0 -1.5
Medication: Lansoprazole 1.6 1.8 9.1 3.0 0.6 0.3 0.9 0.4 1.4 -0.1
Prospective memory result 0.3 0.4 1.4 -0.6 -0.9 -0.3 -0.1 -0.2 0.4 1.2
Lung cancer (father) 0.4 0.5 1.2 -0.1 0.6 1.1 0.9 0.6 0.8 -0.3
Illnesses of mother 0.6 0.7 3.2 -0.5 0.7 -0.4 -1.0 0.0 -1.8 0.1
Forced expiratory volume in 1-second (FEV1), Best measure 0.8 2.5 6.7 0.4 -2.3 -0.8 -1.4 -1.3 -1.1 2.6
Pulse wave Arterial Stiffness index 2.1 2.5 5.9 0.1 -1.5 -0.8 -2.4 -1.9 -1.3 1.9
Impedance of arm (left) 0.1 0.6 1.3 -0.8 -0.4 0.7 0.5 0.8 -1.1 0.8
Arm fat mass (right) 0.3 1.2 2.7 -0.9 0.1 -1.4 -1.5 -1.6 -0.1 -0.8
Trunk predicted mass 0.3 1.6 5.1 0.1 -1.0 -1.0 -2.3 -1.6 0.7 1.1
Standing height 0.3 3.1 8.6 -0.6 -2.1 -0.2 -2.6 -1.1 0.3 2.9
Length of working week for main job 1.0 1.2 7.1 -2.7 -0.6 -0.2 0.5 -0.3 0.5 -0.1
Exposure to tobacco smoke at home 0.2 0.2 0.7 0.4 -0.8 0.5 0.4 0.5 -0.1 0.1
Breastfed as a baby 1.5 1.8 5.6 1.7 -2.4 0.7 0.9 0.2 0.6 1.6
Tense / ‘highly strung’ 0.8 1.3 2.3 1.0 0.5 1.5 1.2 1.3 1.0 -1.2
Seen doctor (GP) for nerves, anxiety, tension or depression 0.2 0.3 1.2 -0.4 0.6 -0.4 -0.6 -0.1 -0.2 -1.1
Hair/balding pattern: Pattern 4 0.2 0.5 2.1 0.0 -0.3 0.3 -0.7 0.1 -1.4 -0.8
Birth weight of first child 1.7 3.2 5.0 -2.2 -1.9 -1.3 -2.2 -2.0 -1.3 1.1
Peak expiratory flow (PEF) 1.2 2.9 7.2 1.0 -1.5 -1.0 -2.1 -1.5 -1.5 2.7
Pulse wave reflection index 0.3 0.4 1.6 1.3 0.2 0.8 -0.5 -0.2 -0.4 -0.3
Ever highly irritable/argumentative for 2 days 1.0 1.2 2.7 -1.6 -0.9 -1.6 -0.9 -1.0 0.7 0.4
Loud music exposure frequency 0.1 0.1 0.4 0.6 -0.6 -0.1 0.3 0.4 -0.1 0.1
Qualifications: O levels/GCSEs or equivalent 1.0 1.6 3.8 -1.4 -1.4 -0.5 -0.8 -0.8 -1.2 2.0
Mouth/teeth dental problems: Bleeding gums 0.3 0.4 1.4 0.0 -0.2 -0.5 0.8 0.0 0.8 -1.2
Blood clot in the leg (DVT) 0.4 0.5 1.5 -1.2 0.0 0.5 -0.1 -0.8 0.1 0.9
Medication: Paracetamol 2.5 4.2 8.1 -0.5 -1.8 -2.8 -2.5 -2.9 -1.2 1.5
Headache pain in last month 0.4 0.7 2.0 0.3 0.3 0.8 1.4 0.4 1.2 -0.6
Medication for cholesterol, blood pressure or diabetes 0.1 0.2 0.5 0.0 -0.6 0.3 0.3 0.5 0.7 0.4
Glaucoma (self-reported) 0.2 0.2 0.7 0.8 0.2 0.1 -0.8 -0.2 0.4 -0.1
Gout (self-reported) 1.7 2.3 9.4 -0.6 -0.0 0.2 2.1 0.6 3.1 -1.3
Hypothyroidism/myxoedema (self-reported) 0.5 1.0 2.1 -0.1 0.8 1.3 1.0 0.8 1.5 -0.8
Medication: Amlodipine 0.4 0.5 1.6 0.3 -1.0 -0.3 0.4 -0.1 1.3 -0.7
Medication: Ventolin 100micrograms inhaler 0.2 0.3 0.8 0.2 0.8 0.4 0.4 -0.4 0.9 -0.4
Birth weight 9.2 20.0 38.4 -1.0 -5.3 -3.0 -5.5 -5.1 -2.6 6.2
Chronic bronchitis/emphysema (mother) 3.9 4.6 7.3 0.3 2.7 2.0 2.6 1.7 1.9 -2.7
High blood pressure (siblings) 4.1 5.9 13.2 1.7 1.9 1.6 3.6 2.5 2.7 -2.3
Forced vital capacity (FVC), Best measure 0.2 0.7 2.1 0.8 -1.2 0.5 -0.4 0.2 0.1 1.5
Body fat percentage 0.2 0.6 1.3 -0.7 0.8 -0.9 -0.4 -0.8 -0.4 -1.1
Leg fat percentage (right) 0.2 0.6 2.2 -0.0 1.1 -0.6 0.5 0.1 -0.0 -1.5
Arm fat-free mass (right) 0.1 0.5 1.8 0.2 -0.1 -0.5 -1.3 -0.6 1.0 0.5
Exposure to tobacco smoke outside home 0.3 0.4 1.0 -0.5 0.7 -0.3 -1.0 0.3 -0.1 -0.8
Comparative body size at age 10 1.3 3.6 9.2 -0.6 -0.7 -1.0 -3.0 -1.9 -2.9 1.4
Number of full brothers 0.3 0.3 1.0 -0.6 0.4 -0.5 -0.4 -0.4 1.0 -0.2
Worry too long after embarrassment 0.3 0.6 1.3 0.3 -1.1 -0.6 0.2 -0.9 -1.1 0.4
Seen a psychiatrist for nerves, anxiety, tension or depression 1.0 1.3 2.4 -1.6 1.3 -0.3 -1.5 -0.7 -1.4 -0.1
Wheeze or whistling in the chest in last year 1.4 2.5 4.5 -2.0 1.0 -0.9 1.9 0.4 1.9 -2.1
Number of children fathered 0.8 0.9 2.7 1.7 0.4 -0.0 1.4 0.6 1.0 -0.5
Reason for reducing amount of alcohol drunk: Health precaution 0.5 0.6 1.7 1.3 0.7 1.2 0.4 0.8 -0.1 0.1
Age at first live birth 0.4 0.7 2.8 0.6 -0.3 0.8 -1.0 0.2 -1.7 0.3
Pulse wave peak to peak time 1.8 2.2 5.1 -0.3 1.3 0.8 2.3 1.8 1.2 -1.7
Health satisfaction 0.3 0.4 1.0 -1.0 -0.4 -0.2 -0.2 -0.5 -0.0 1.0
Shortness of breath walking on level ground 1.1 1.3 3.3 -1.6 -0.3 -1.8 -0.4 -0.8 0.2 -1.4
Qualifications: College or University degree 0.7 2.2 7.9 -0.0 -0.2 2.8 1.4 1.3 2.0 0.5
Eye problems/disorders: None of the above 1.3 1.5 3.2 0.2 1.8 1.0 1.6 1.1 0.1 -1.5
Mouth/teeth dental problems: Loose teeth 0.7 0.8 1.9 0.3 1.4 -0.2 1.4 -0.5 1.0 -0.9
Emphysema/chronic bronchitis 0.3 0.3 1.4 -0.3 -0.1 -0.1 0.1 0.8 0.3 -1.2
Medication for pain relief, constipation, heartburn 0.2 0.4 1.3 -1.1 0.6 0.7 0.1 0.8 -0.3 -0.1
Neck or shoulder pain in last month 0.2 0.2 0.9 -0.2 -0.5 -0.9 -0.0 -0.6 -0.0 0.2
Medication: Blood pressure 0.3 0.5 1.2 -0.1 1.0 -0.2 0.9 0.4 -0.0 -1.1
Angina (self-reported) 0.6 0.7 1.6 0.5 1.0 1.2 0.8 1.3 0.5 -0.3
Migraine (self-reported) 0.4 0.5 2.0 0.0 -0.3 0.3 0.8 -0.1 -1.4 0.9
Medication: Ibuprofen 0.2 0.2 0.5 -0.1 -0.7 0.2 0.1 -0.7 0.3 0.7
Medication: Allopurinol 1.5 2.0 6.1 0.1 0.3 0.9 2.5 1.0 2.0 -1.5
Medication: Omeprazole 0.2 0.3 1.5 -1.2 -0.4 0.1 0.1 0.2 0.5 -0.1
Medication: Seretide 50 evohaler 0.5 0.6 2.0 0.1 -0.8 1.0 0.1 -0.5 1.4 0.2
Mean time to correctly identify matches 0.2 0.3 1.1 0.5 0.2 0.3 -0.6 -1.1 -0.1 0.3
Heart disease (mother) 2.0 2.4 5.1 -1.4 -1.4 -2.3 -1.4 -1.5 -1.3 1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.5 0.6 1.3 1.1 0.5 -0.7 0.8 0.5 -0.6 -0.9
Whole body fat mass 0.2 0.8 1.8 -0.9 0.3 -1.2 -1.2 -1.3 -0.3 -0.5
Leg fat mass (right) 0.1 0.5 1.2 -0.6 0.3 -1.1 -0.7 -0.9 0.1 -0.7
Arm predicted mass (right) 0.1 0.6 1.8 0.5 -0.1 -0.3 -1.3 -0.6 1.2 0.5
Pulse rate, automated reading 0.5 1.5 4.8 -1.0 -0.4 -2.2 -1.3 -1.6 -0.8 0.5
Alcohol intake frequency. 0.9 2.1 5.8 0.9 1.9 0.3 1.1 1.1 1.4 -2.4
Comparative height size at age 10 0.2 1.0 4.3 0.2 -2.1 -0.4 -0.4 -0.9 -0.1 1.2
Number of full sisters 0.3 0.4 1.1 0.7 1.1 -0.4 -0.3 -0.5 -0.1 -0.8
Suffer from ‘nerves’ 0.2 0.3 0.8 0.9 0.5 -0.0 0.2 0.7 -0.1 -0.9
Overall health rating 0.4 1.0 2.8 0.2 1.0 -0.7 1.7 0.8 -0.0 -1.3
Chest pain or discomfort 1.3 1.8 4.4 -0.5 1.9 -0.1 1.6 0.7 1.2 -2.1
Had major operations 1.1 1.3 6.0 0.5 -0.1 0.9 1.0 0.8 2.4 0.1
Age at last live birth 0.3 0.4 1.7 0.2 -0.3 1.3 -0.3 0.6 -0.0 0.6
Family relationship satisfaction 0.5 0.6 1.5 -0.1 -0.7 -1.2 -0.8 -0.9 0.7 0.7
Leg pain on walking 1.0 1.3 2.4 1.1 0.8 -0.7 1.5 0.3 1.5 -1.4
Qualifications: NVQ or HND or HNC or equivalent 1.6 1.9 7.3 -0.7 -0.3 -1.2 -1.8 -0.6 -2.7 -0.3
Commuting to job workplace: Car/motor vehicle 2.3 2.6 5.9 1.5 1.3 0.6 1.5 1.7 2.4 -1.6
Illness, injury, bereavement, stress in last 2 years 2.7 3.3 6.6 -0.9 -2.6 -0.5 -2.2 -2.0 -0.8 2.4
Medication: Aspirin 0.2 0.2 0.8 0.4 0.0 0.3 0.5 0.4 -0.9 0.0
Supplements: Vitamin C 0.7 0.9 2.2 -1.5 0.7 -0.5 -0.3 -0.9 1.2 -0.9
Knee pain experienced in last month 1.6 2.5 7.5 -0.0 1.1 -2.7 1.3 -0.8 2.2 -1.3
Hypertension (Self-reported) 0.4 1.1 5.9 2.4 0.4 -0.0 0.5 0.2 0.9 -0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.1 0.1 0.3 -0.1 0.1 -0.2 -0.3 -0.1 -0.6 -0.4
Illnesses of father: Heart disease 1.0 1.4 2.7 0.7 -1.4 -0.9 -1.6 -1.5 -0.6 1.1
Illnesses of siblings: Diabetes 3.0 3.7 6.4 2.0 2.1 2.1 2.1 1.5 0.7 -2.5
Smoking status: Previous 1.5 2.2 5.2 0.6 0.8 0.4 2.1 0.9 2.1 -2.3
Forced expiratory volume in 1-second (FEV1), predicted 0.4 0.9 3.8 1.2 0.2 1.0 0.4 2.0 0.3 0.1
Whole body fat-free mass 0.3 1.6 5.3 -0.1 -0.9 -1.1 -2.3 -1.7 0.6 0.8
Leg fat-free mass (right) 0.4 2.0 5.9 -0.6 -0.7 -1.6 -2.4 -2.0 0.3 0.7
Arm fat percentage (left) 0.2 0.7 1.6 -1.0 0.8 -0.9 -0.5 -0.9 -0.4 -1.3
Average weekly red wine intake 0.5 0.7 4.4 -2.1 0.1 0.3 -0.6 -0.3 0.2 -0.1
Handedness (chirality/laterality): Left-handed 0.8 1.0 3.8 -0.8 1.0 -0.3 -0.1 0.4 1.1 -1.9
Mood swings 0.2 0.4 0.9 1.0 0.6 0.1 0.4 0.9 0.1 -0.3
Loneliness, isolation 0.1 0.1 0.2 0.1 0.5 -0.2 -0.2 -0.5 -0.1 -0.0
Long-standing illness, disability or infirmity 0.5 0.8 2.6 0.0 1.0 -0.3 1.6 0.4 0.9 -0.9
Ever had bowel cancer screening 1.0 1.1 2.4 -0.5 -1.1 -1.6 -0.4 -1.3 -0.8 1.3
Diabetes diagnosed by doctor 0.1 0.1 0.2 -0.5 0.2 -0.4 0.1 -0.3 -0.2 -0.4
Ever had stillbirth, spontaneous miscarriage or termination 0.9 1.0 3.1 -0.5 1.8 -1.3 -0.8 -0.5 0.6 -0.7
Friendships satisfaction 0.3 0.4 1.0 -0.8 -0.1 -1.0 -0.5 -0.7 -0.6 -0.1
Qualifications: nursing, teaching 0.6 0.9 4.3 -2.1 -1.0 -0.2 -0.6 -0.3 -0.2 0.8
Commuting to job workplace: Walk 2.0 2.1 4.6 -0.5 -1.4 -0.4 -1.5 -1.8 -1.6 2.1
Eye problems/disorders: Cataract 1.0 1.2 2.3 -0.2 -1.4 -1.5 -1.1 -0.9 -0.9 0.9
Mouth/teeth dental problems: Mouth ulcers 0.1 0.2 0.8 -0.1 0.3 -0.1 -0.9 -0.4 -0.0 0.3
Medication for cholesterol 0.5 0.8 2.6 -1.1 -0.7 0.4 -0.3 -0.8 -0.1 1.6
Medication: Laxatives (e.g. Dulcolax, Senokot) 1.6 1.9 6.0 1.2 -2.4 -1.3 -0.6 -1.2 -0.3 1.4
Back pain experienced in last month 0.5 0.7 2.4 0.4 -0.2 -1.4 -0.1 -0.2 -1.5 0.3
Mineral and other dietary supplements 2.5 3.4 9.2 -0.2 1.5 2.1 0.7 2.5 -1.0 -3.0
Breast cancer (self-reported) 0.7 0.9 2.6 -1.6 -0.5 -0.6 0.3 -0.3 -1.4 0.9
Asthma (self-reported) 1.6 3.2 6.5 0.6 1.4 1.2 2.5 1.2 2.5 -2.2
Osteoporosis (self-reported) 1.0 1.3 5.0 -0.7 -0.4 1.1 2.2 1.2 0.4 0.4
Osteoarthritis (self-reported) 0.8 1.0 4.6 0.5 0.3 0.5 1.3 0.1 2.1 -0.5
Medication: Aspirin 0.2 0.2 0.5 0.6 -0.1 0.7 0.6 0.6 -0.0 0.2
Medication: Gliclazide 2.3 2.6 4.9 0.9 -0.7 -1.5 -2.0 -2.2 -1.7 1.6
Illnesses of father: None of the above (group 1) 0.5 0.6 2.0 -1.4 0.1 0.1 1.0 0.7 -0.9 -0.5
Smoking status: Current 0.5 0.7 1.4 -0.5 0.8 -0.5 -1.2 -0.6 -1.0 -1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage 0.5 1.0 2.3 0.8 -1.5 1.2 -0.3 0.1 0.6 1.5
Whole body water mass 0.3 1.5 4.9 0.0 -0.9 -1.0 -2.2 -1.6 0.8 0.7
Leg predicted mass (right) 0.4 2.1 6.3 -0.7 -0.8 -1.6 -2.5 -2.1 0.3 0.8
Arm fat mass (left) 0.2 0.7 1.2 -0.7 0.6 -0.9 -0.9 -1.1 0.1 -1.0
Number of self-reported non-cancer illnesses 0.5 0.9 3.1 -0.0 -0.5 0.3 1.3 -0.9 1.8 0.6
Average weekly champagne plus white wine intake 1.0 1.3 4.4 -0.1 -0.6 2.1 -1.7 0.4 0.6 1.2
Miserableness 0.4 0.7 2.1 -0.5 -0.6 -1.4 -1.0 -0.5 -0.7 0.1
Guilty feelings 0.3 0.5 1.2 -0.2 -1.1 -1.0 -0.1 -0.9 0.2 -0.1
Wears glasses or contact lenses 0.6 0.6 1.8 -1.3 -0.4 0.1 -0.3 -0.8 0.0 1.3
Ever taken oral contraceptive pill 1.2 1.3 3.6 0.5 -0.6 -1.8 -1.3 -1.9 0.2 0.2
Hearing aid user 0.5 0.5 1.8 -0.4 0.5 -0.4 -1.4 -0.5 0.1 1.1
Mother’s age at death 0.4 0.5 1.1 -0.0 -1.1 -0.9 0.6 -0.7 0.7 0.1
Financial situation satisfaction 0.5 0.6 1.8 1.1 -0.3 0.7 0.6 0.6 1.3 0.2
Tinnitus: Yes, now most or all of the time 1.5 1.7 5.6 0.4 0.3 -1.2 -1.9 -1.0 -2.4 -0.1
Commuting to job workplace: Public transport 1.0 1.2 3.4 1.0 -1.8 0.8 -0.8 -0.1 0.0 1.6
Eye problems/disorders: Glaucoma 0.2 0.3 1.2 -0.1 0.5 1.1 -0.3 0.4 0.6 -0.3
Medication: Blood pressure 0.4 0.8 3.0 1.7 0.4 -0.2 0.6 0.6 0.8 -1.1
Pain type(s) experienced in last month: Hip pain 0.6 0.7 2.5 0.8 0.7 -1.6 0.6 -0.8 -0.3 -0.3
Supplements: Fish oil (including cod liver oil) 1.1 1.4 4.4 0.2 -0.2 -1.4 -0.7 -1.5 0.6 2.1
High cholesterol (Self-reported) 0.3 0.5 1.1 -0.7 -0.4 -0.9 -0.9 -1.1 -0.4 0.2
Medication: Bendroflumethiazide 0.6 1.0 3.2 0.6 0.6 -1.8 0.7 -0.5 -0.1 -1.4
Medication: Paracetamol 2.0 3.0 6.0 -0.6 -1.6 -2.2 -2.3 -2.5 -0.9 1.2
Medication: Lisinopril 0.4 0.5 1.5 1.2 0.2 -0.7 0.2 0.1 -1.1 -0.5
Medication: Atorvastatin 0.1 0.2 0.4 -0.0 -0.1 -0.4 -0.6 -0.3 0.3 0.6
Illnesses of father: High blood pressure 0.6 0.8 1.5 0.9 -0.7 1.2 0.9 1.1 0.8 -0.0
Alcohol drinker status: Never 2.0 2.4 5.2 1.3 2.2 2.3 0.9 1.2 0.4 -1.7
Ever smoked 0.4 0.6 3.4 -0.2 0.5 -0.1 0.6 -0.2 0.5 -1.8
Basal metabolic rate 0.2 1.3 4.5 -0.2 -0.7 -1.1 -2.1 -1.6 0.7 0.5
Leg fat percentage (left) 0.3 1.0 3.1 -0.1 1.7 -0.6 0.6 0.3 -0.3 -1.7
Arm fat-free mass (left) 0.2 0.9 2.9 0.4 -0.1 -0.7 -1.7 -1.0 1.2 0.1
Number of operations (self-reported) 0.2 0.4 0.8 0.3 0.9 0.7 0.6 0.9 -0.2 0.0
Average weekly beer plus cider intake 0.3 0.5 2.0 -0.6 -1.4 -0.5 -0.5 -0.4 0.4 0.5
Irritability 0.4 0.7 3.1 -0.1 -0.7 -1.8 -0.1 -0.8 -0.4 -0.6
Risk taking 2.7 3.9 10.8 0.2 1.9 1.9 1.3 1.4 3.3 -2.3
Ever had prostate specific antigen (PSA) test 0.3 0.4 1.4 -1.2 -0.2 -0.7 -0.5 -0.5 0.3 -0.0
Fractured/broken bones in last 5 years 1.5 1.9 3.0 0.2 -1.7 -1.0 -1.6 -0.9 -1.7 1.7
Age started oral contraceptive pill 0.3 0.4 1.1 0.7 -1.0 0.9 -0.3 0.2 0.0 0.3
Diastolic blood pressure, automated reading 0.3 0.9 3.1 -0.4 0.0 -0.6 -1.8 -0.7 -1.1 0.9
Ever depressed for a whole week 4.2 5.2 9.8 -1.0 -1.2 -3.1 -3.0 -2.8 -2.2 1.5
Unable to work because of sickness or disability 1.6 2.0 4.8 1.2 1.6 0.2 0.8 1.1 1.9 -2.2
Commuting to job workplace: Cycle 0.8 1.0 5.6 -2.4 -0.4 -0.4 0.6 -0.1 -0.1 -0.8
Myopia 0.1 0.1 0.4 0.1 -0.3 -0.4 -0.2 -0.6 -0.4 -0.1
Vascular/heart problems diagnosed by doctor 0.3 0.7 4.4 -2.1 -0.0 0.3 -0.4 -0.1 -0.4 0.5
Cholesterol lowering medication 0.3 0.4 1.8 0.1 -1.4 -0.8 -0.3 -0.2 0.2 0.4
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.9 -0.4 -0.5 -0.3 0.2 0.1 1.0 0.0
Pain experienced in last month 1.0 1.7 5.2 -1.1 -1.6 1.1 -2.3 -0.6 -0.4 1.1
Supplements: Calcium 0.4 0.5 1.5 0.5 -0.5 -0.4 -0.4 -0.5 0.9 1.2
Basal cell carcinoma (self-reported) 0.3 0.4 0.8 0.4 0.9 -0.4 0.8 0.5 0.6 -0.4
Heart attack/myocardial infarction (self-reported) 0.8 1.0 2.3 -1.5 0.9 -0.3 1.5 0.9 -0.1 -1.0
Deep venous thrombosis (DVT) (self-reported) 0.4 0.6 1.7 -1.3 -0.1 0.2 -0.2 -1.0 -0.1 1.1
Heart disease (siblings) 2.9 3.6 6.2 0.7 1.4 1.3 2.2 2.2 2.1 -2.5
Alcohol drinker status: Previous 0.3 0.3 0.8 0.6 -0.3 0.4 0.6 0.4 0.2 -0.9
Pack years of smoking 0.6 0.9 2.3 1.0 1.5 0.3 0.3 0.4 -0.7 -1.5
Impedance of whole body 0.2 1.0 2.7 -0.6 0.1 1.2 1.1 1.7 -0.8 0.3
Leg fat mass (left) 0.1 0.6 1.4 -0.6 0.7 -1.2 -0.7 -0.8 -0.1 -0.8
Arm predicted mass (left) 0.2 1.1 4.3 0.2 -0.3 -1.0 -2.1 -1.3 0.9 0.3