Hub : Genes

WSB1

Models

#	panel	tissue	h2	h2 se	h2 P	eQTL R2	BLUP R2	ENET R2	BSLMM R2	LASSO R2	eQTL P	BLUP P	ENET P	BSLMM P	LASSO P
1	GTEx	Pituitary	0.2110	0.0940	4.0e-03	-0.012	NA	0.050	NA	0.026	9.2e-01	NA	2.2e-02	NA	7.4e-02
2	GTEx	Thyroid	0.0670	0.0300	7.1e-03	-0.004	NA	0.000	NA	-0.002	9.4e-01	NA	3.2e-01	NA	5.8e-01
3	METSIM	Adipose	0.0677	0.0335	2.3e-03	-0.002	0.016	0.017	0.019	0.000	9.8e-01	1.6e-03	1.0e-03	6.4e-04	3.6e-01
4	NTR	Blood	0.0555	0.0175	8.7e-08	0.014	0.017	0.028	0.026	0.033	2.2e-05	2.2e-06	1.4e-09	8.2e-09	6.1e-11
5	YFS	Blood	0.0605	0.0169	6.2e-11	0.033	0.036	0.040	0.036	0.040	6.3e-11	7.1e-12	3.9e-13	5.5e-12	5.5e-13
6	TCGA	Testicular Germ Cell Tumors	0.2380	0.1040	1.2e-03	-0.007	0.033	0.042	NA	0.017	7.1e-01	2.5e-02	1.3e-02	NA	7.9e-02
7	TCGA	Thyroid Carcinoma	0.0470	0.0260	3.7e-04	0.045	0.036	0.040	NA	0.038	3.1e-05	2.0e-04	8.9e-05	NA	1.2e-04

Trait associations

Trait	Avg chi2 ratio	Avg chi2	Max chi2	1	2	3	4	5	6	7
Bipolar Disorder (2018)	0.5	0.9	1.9	-0.3	0.5	0.8	1.4	1.4	0.3	-1.1
Bipolar Disorder or Schizophrenia	0.1	0.2	0.3	0.3	-0.6	-0.4	-0.5	-0.2	-0.5	-0.3
Depressed Affect (Nagel 2018)	0.3	0.6	1.4	0.8	-0.8	-1.2	-0.4	-0.5	0.8	0.3
Depression (Nagel 2018)	0.4	0.6	1.7	0.3	-1.3	-0.6	0.9	0.2	0.9	-0.6
Intelligence (Savage-Jansen 2018)	0.4	1.2	2.2	-0.4	-0.4	-1.4	-1.5	-1.2	0.9	1.3
Neuroticism (Nagel 2018)	0.2	0.4	0.8	0.9	0.0	-0.8	0.2	-0.3	0.9	-0.6
Schizophrenia (2018)	0.6	1.3	3.1	0.7	-1.2	-1.1	-1.8	-1.4	-1.0	0.5
Schizophrenia vs Biploar Disorder	3.6	4.7	10.7	-3.3	-2.2	-2.8	-1.9	-2.2	-0.2	0.9
Worry (Nagel 2018)	0.3	0.7	1.5	0.9	1.1	0.5	0.3	0.4	1.0	-1.2
Alzheimer’s Disease (in mother)	0.6	0.7	3.2	-0.5	0.3	0.9	-0.0	0.6	1.8	-0.4
Alzheimer’s Disease (in father)	1.2	1.3	2.9	1.2	-0.2	0.1	-1.7	-1.4	1.0	1.3
Alzheimer’s Disease (including proxy)	0.6	0.9	2.4	0.4	0.3	0.8	-1.5	-0.5	1.6	0.7
Crohns Disease (2017)	0.6	1.3	3.3	-0.1	1.6	-0.7	-1.5	-0.5	-1.8	-0.2
Irritable Bowel Disease (IBD)	0.1	0.3	0.9	-0.6	1.0	-0.1	-0.3	-0.7	0.1	-0.0
Ulcerative Colitis (UC)	0.3	0.6	2.1	-0.9	-0.2	0.4	0.9	-0.5	1.4	0.1
Major Depression (MDD)	0.8	1.0	2.3	1.5	0.5	0.7	-0.4	0.4	1.3	-1.3
Reaction Time	0.1	0.3	1.0	0.1	0.1	0.2	-0.7	-1.0	-0.5	0.4
Verbal and Numeric Reasoning (VNR)	0.1	0.2	0.5	0.0	-0.4	-0.5	-0.5	-0.1	0.3	0.7
Breast Cancer	0.7	1.6	4.9	1.5	-1.5	2.2	0.6	0.7	0.8	0.6
Ovarian Cancer	0.4	0.5	1.5	1.1	-1.2	0.5	0.8	0.3	-0.0	-0.2
Prostate Cancer	0.4	0.6	1.6	-0.8	-1.3	-0.3	1.2	-0.1	0.5	0.1
Age at First Birth	2.2	3.2	7.3	0.1	-1.1	-1.8	-2.7	-1.6	-1.9	2.1
Bipolar Disorder (2011)	0.9	0.9	1.9	1.0	0.1	0.8	1.4	1.1	0.8	-0.8
Body Mass Index (BMI) (2010)	2.1	2.9	5.2	2.0	1.6	0.7	1.5	2.3	1.3	-2.1
Coronary Artery Disease (CAD)	1.1	1.3	3.9	-1.5	-0.5	-2.0	-0.8	-0.8	-0.2	1.1
Crohns Disease (2012)	0.6	1.0	3.5	0.3	0.7	-0.2	-1.5	-0.1	-1.9	-0.8
Mean Putamen Volume	1.5	1.7	3.3	-1.0	-1.6	-0.8	-0.2	-1.4	1.5	1.8
Fasting Glucose	0.1	0.1	0.3	0.3	0.5	0.4	-0.4	-0.1	-0.5	-0.0
HbA1C	1.1	1.2	2.4	0.7	-1.3	-1.2	-0.9	-1.1	-0.7	1.6
HDL Cholesterol	1.9	3.1	4.5	1.3	1.7	1.9	2.1	1.8	1.6	-1.8
LDL Cholesterol	1.7	2.6	7.6	0.6	1.6	0.7	2.8	1.9	-0.5	-1.9
Lupus	0.4	0.6	1.0	0.9	0.8	-0.9	-1.0	-0.1	0.4	-0.8
Neuroticism (2016)	0.9	1.3	3.1	0.6	1.3	0.5	0.9	1.2	1.3	-1.8
Primary Biliary Cirrhosis	1.1	1.6	5.7	-0.7	-0.4	-0.5	-2.4	-0.2	-1.8	1.1
Rheumatoid Arthritis	0.3	0.4	2.0	-0.6	-0.2	-0.1	-1.4	-0.0	-0.0	0.4
Schizophrenia (2014)	0.7	1.5	3.3	-0.6	-1.3	-1.5	-1.4	-1.8	-0.9	0.2
Triglycerides	0.2	0.4	0.9	-0.4	-0.6	-0.9	0.9	-0.1	-0.2	-0.6
Type 2 Diabetes (T2D) (2012)	0.5	0.6	1.5	-1.2	0.7	0.4	0.0	0.5	0.8	-1.0
Ulcerative Colitis	0.6	0.9	3.1	-1.2	-0.0	1.0	0.5	-0.3	1.8	0.3
Blood Eosinophil Count	0.5	3.8	10.6	3.3	-2.0	2.4	1.0	-0.3	2.2	0.8
Blood Platelet Count	0.1	1.6	3.5	-1.1	-0.3	-1.5	-1.5	-1.9	-0.8	1.2
Blood Red Count	0.2	2.0	6.7	-0.6	-1.0	1.2	-1.5	-0.3	-1.2	2.6
Blood White Count	0.6	4.6	11.5	2.3	-0.1	2.4	3.4	1.2	2.7	-1.0
Heel T-Score	1.9	15.4	25.5	1.6	4.3	3.3	4.3	4.1	3.7	-5.0
BMI	0.2	1.1	4.2	0.3	1.4	-0.9	-0.4	-0.2	0.3	-2.1
Height	0.7	12.7	36.5	0.0	-4.4	-0.7	-4.4	-3.5	-1.1	6.0
Waist Hip Ratio (WHR)	1.1	4.7	11.2	-0.7	-1.0	-3.4	-2.2	-3.0	-1.7	2.0
Systolic Blood Pressure	0.1	0.5	1.1	0.4	0.6	-1.0	-0.6	-0.6	0.2	-0.9
Smoking Status	0.4	0.9	3.9	-0.3	0.7	-0.1	0.5	0.1	1.2	-2.0
Allergy or Eczema	1.4	3.6	8.0	-0.7	-1.9	-1.7	-1.9	-2.8	-1.4	2.2
Cardiovascular Disease	0.4	1.2	6.7	2.6	0.3	-0.8	-0.0	-0.5	0.6	-0.8
Hypothyroidism (self reported)	0.4	0.8	1.5	0.2	1.2	0.6	0.8	0.9	0.9	-1.2
Respiratory disease	1.8	4.0	8.7	-0.2	1.5	0.5	3.0	1.2	2.8	-2.7
Type 2 Diabetes (T2D) (2018)	0.2	0.4	1.2	-0.6	0.5	-1.1	0.6	-0.0	0.7	-0.2
Lung FEV1/FVC ratio	3.0	15.1	20.9	-1.4	-3.7	-4.0	-4.5	-4.6	-4.1	4.1
Lung FVC	0.5	2.6	8.8	3.0	1.2	1.9	1.2	1.5	1.0	-0.2
Neuroticism	0.2	0.5	1.7	1.3	-0.1	-0.1	0.5	0.5	0.8	-0.8
Chronotype (morning person)	1.5	3.5	6.0	0.4	2.3	1.5	2.2	2.4	1.1	-2.3
Hair Pigment	0.1	2.2	7.0	-2.6	1.1	-2.4	-0.1	-1.1	0.3	0.2
Tanning	0.0	0.6	1.1	-0.6	-0.5	0.5	-0.9	0.6	-1.0	0.9
Hand grip strength (left)	0.2	0.6	1.4	0.3	-0.9	1.1	0.2	0.4	1.2	0.4
Number of treatments/medications taken	0.3	0.5	2.1	0.2	-0.1	-0.8	-0.6	-1.4	-0.1	0.7
Average weekly spirits intake	0.2	0.3	1.6	-1.3	0.1	0.2	-0.3	0.1	-0.2	-0.2
Sensitivity / hurt feelings	0.7	1.2	2.0	-0.8	-1.1	-1.4	-1.4	-1.1	-1.0	0.5
Frequency of depressed mood in last 2 weeks	0.2	0.3	0.8	-0.4	-0.3	0.1	0.2	0.4	-0.9	-0.7
Hearing difficulty/problems: Yes	0.9	1.3	3.0	-0.1	1.6	0.8	0.3	1.7	-0.2	-1.7
Relative age of first facial hair	0.1	0.2	0.7	-0.5	-0.1	0.0	-0.8	-0.2	-0.6	0.5
Other serious medical condition/disability diagnosed by doctor	0.4	0.5	1.9	-0.5	0.1	1.4	0.3	0.6	0.8	-0.3
Ever used hormone-replacement therapy (HRT)	0.6	0.8	1.9	1.4	-0.0	-1.2	1.3	-0.1	0.1	-0.0
Ever had hysterectomy (womb removed)	0.5	0.6	1.5	0.7	0.9	-1.2	-0.2	0.1	-1.2	-0.1
Systolic blood pressure, automated reading	0.1	0.2	0.6	0.4	-0.3	0.1	-0.3	-0.5	0.8	0.2
Eye problems/disorders: Diabetes related eye disease	0.7	0.8	2.0	1.1	-0.2	1.1	0.6	1.4	0.6	-0.2
Angina	0.9	1.2	2.3	0.8	1.0	1.5	1.1	1.5	0.8	-0.4
Medication for hormone replacement therapy	1.6	1.8	6.1	-0.4	2.5	0.2	0.9	1.0	0.4	-2.0
Vitamin and mineral supplements	0.3	0.5	2.2	0.9	-0.1	-0.3	-0.0	-0.2	-1.5	-0.1
Supplements: Zinc	1.0	1.0	3.8	-0.4	0.4	-1.9	-1.0	-1.3	0.4	-0.2
Medication: Co-codamol	0.7	0.8	2.4	0.3	0.9	0.1	0.9	0.6	1.0	-1.6
Medication: Metformin	0.2	0.3	0.6	-0.4	0.3	-0.8	0.1	-0.6	-0.4	-0.7
Diabetes (father)	2.4	3.0	6.5	1.5	1.8	2.6	0.8	1.8	1.6	-1.5
Diabetes (mother)	0.7	0.9	2.8	1.7	-0.4	-0.6	-0.8	-0.9	-0.6	1.0
Severe depression (siblings)	0.8	0.9	2.1	-1.0	0.9	0.5	0.8	1.0	1.4	-0.8
Pack years adult smoking proportion	0.6	0.8	2.4	0.8	1.3	0.4	0.3	0.5	-0.8	-1.6
Impedance of leg (right)	0.4	1.7	6.2	0.1	0.3	1.6	1.7	2.5	-0.4	-0.3
Leg fat-free mass (left)	0.4	2.0	5.7	-0.5	-1.0	-1.5	-2.4	-2.1	0.5	0.8
Trunk fat percentage	0.2	0.7	1.0	-0.8	0.8	-1.0	-0.7	-1.0	-0.5	-1.0
Hand grip strength (right)	0.4	1.0	1.9	-0.4	-1.4	1.1	0.9	0.8	1.4	0.2
Townsend deprivation index at recruitment	0.6	0.9	2.4	0.1	1.5	-0.4	0.8	-0.3	0.6	-1.6
Current tobacco smoking	0.5	0.8	1.9	-0.7	0.4	-0.8	-1.2	-0.7	-1.4	-0.7
Average weekly fortified wine intake	1.5	1.8	3.1	-1.5	-1.7	-1.7	-0.7	-1.4	-1.4	0.0
Maternal smoking around birth	1.8	2.6	5.1	0.3	1.3	1.8	2.3	1.8	1.6	-1.4
Fed-up feelings	0.3	0.6	1.8	-0.1	-1.1	-1.4	-0.4	-0.8	-0.0	0.3
Frequency of unenthusiasm / disinterest in last 2 weeks	0.4	0.6	1.2	1.1	-1.1	-0.9	0.7	0.3	-0.0	-0.4
Relative age voice broke	0.7	1.1	5.2	0.5	-0.4	-0.5	-2.3	-0.7	-1.1	0.6
Taking other prescription medications	0.5	0.7	2.2	0.8	0.2	0.4	1.4	-0.0	1.5	-0.0
Age when periods started (menarche)	0.3	0.8	2.8	-0.2	-0.6	-0.4	-1.7	-0.8	-1.2	0.3
Bilateral oophorectomy (both ovaries removed)	0.1	0.1	0.4	0.4	0.1	-0.3	0.1	0.1	-0.6	0.1
Heel bone mineral density (BMD) T-score, automated (left)	0.3	0.8	2.4	-1.3	0.1	0.1	1.0	0.4	1.6	-0.3
Tinnitus: Yes, but not now, but have in the past	1.8	1.9	4.6	-2.1	-0.5	-0.9	-2.1	-1.1	-0.0	1.4
Qualifications: CSEs or equivalent	1.0	1.4	7.8	-0.4	-0.8	0.0	-2.8	-0.7	-0.5	0.5
Serious illness, injury or assault to yourself	0.7	0.8	2.4	-0.3	1.4	0.6	0.2	1.5	-1.0	-0.1
High blood pressure	0.3	0.9	5.4	2.3	0.2	-0.0	0.1	0.1	0.8	-0.5
Hayfever, allergic rhinitis or eczema	1.7	3.7	8.7	-0.6	-1.4	-1.8	-2.0	-3.0	-1.8	2.1
Multivitamins +/- minerals	0.4	0.5	1.2	-0.8	-0.1	-0.6	-1.1	-0.4	0.7	0.6
Stomach or abdominal pain in last month	0.4	0.5	0.8	-0.9	0.6	0.3	0.9	0.9	-0.5	-0.5
Supplements: Glucosamine	2.3	2.9	10.4	3.2	-0.7	-0.9	-1.1	-1.9	0.5	1.9
Diverticular disease/diverticulitis (self-reported)	0.3	0.3	1.5	0.3	1.2	-0.4	-0.6	-0.1	-0.0	-0.3
Medication: Atenolol	0.3	0.4	1.0	-1.0	0.9	0.3	0.0	0.4	-0.1	-0.8
Medication: Levothyroxine sodium	1.1	1.9	3.7	0.6	1.2	1.2	1.1	1.8	1.3	-1.9
Sitting height	0.1	0.6	2.1	-0.3	-1.1	-0.3	-0.7	0.2	0.1	1.5
Chronic bronchitis/emphysema (father)	1.7	2.0	4.7	1.2	1.1	1.1	1.9	1.1	2.2	-0.9
High blood pressure (mother)	0.7	1.0	1.5	-0.2	-1.1	-1.1	-1.2	-1.1	-1.2	0.5
Body mass index (BMI)	0.2	0.8	2.0	-0.1	1.0	-1.1	-0.4	-0.9	0.4	-1.4
Impedance of leg (left)	0.4	2.0	6.7	-0.3	1.0	1.6	1.6	2.6	-0.9	-0.4
Leg predicted mass (left)	0.4	2.0	5.3	-0.6	-1.0	-1.4	-2.3	-2.0	0.5	0.8
Trunk fat mass	0.2	0.9	2.2	-0.8	0.3	-1.3	-1.3	-1.5	-0.3	-0.4
Waist circumference	0.5	1.9	4.9	-0.4	0.4	-2.2	-1.7	-2.2	-0.6	0.2
Number of incorrect matches in round	0.2	0.4	0.8	0.1	0.5	0.2	0.6	0.8	0.9	-0.9
Past tobacco smoking	1.3	2.5	8.6	-0.6	-1.4	-0.5	-1.5	-0.8	-1.8	2.9
Alcohol usually taken with meals	0.4	0.7	3.2	-0.6	0.7	1.8	0.3	0.2	0.6	0.3
Nervous feelings	0.4	0.7	2.1	1.4	0.6	0.8	-0.6	0.8	0.3	-0.9
Frequency of tenseness / restlessness in last 2 weeks	0.4	0.5	2.2	-0.0	0.7	0.5	0.1	1.5	-0.0	-0.9
Hearing difficulty/problems with background noise	0.7	1.2	3.1	-1.0	1.5	-0.3	-1.2	0.5	-0.3	-1.8
Hair/balding pattern: Pattern 2	0.2	0.2	0.6	0.1	-0.6	-0.4	-0.1	-0.2	-0.4	0.8
Had menopause	0.2	0.2	1.0	1.0	0.2	0.0	0.6	0.1	-0.4	0.1
Had other major operations	0.2	0.3	0.9	-0.3	1.0	-0.1	0.3	0.9	0.0	-0.4
Forced vital capacity (FVC)	0.2	0.6	2.0	1.0	-0.7	0.2	-0.5	0.0	0.5	1.4
Heel bone mineral density (BMD) T-score, automated (right)	0.2	0.4	1.2	-1.1	0.2	0.8	0.5	0.3	0.8	-0.1
Ever unenthusiastic/disinterested for a whole week	1.0	1.2	4.3	-0.1	-0.6	-2.1	-1.3	-1.1	-0.9	0.0
Qualifications: None of the above	0.8	1.8	3.3	1.6	1.6	0.1	1.8	0.3	1.5	-1.3
Financial difficulties in last 2 years	2.9	3.9	8.1	0.3	2.7	0.9	1.8	2.3	1.6	-2.8
Mouth/teeth dental problems	0.2	0.4	1.6	-0.3	0.6	-0.5	-0.5	-0.2	-1.3	0.1
Heart attack	0.9	1.1	2.6	-1.2	1.1	-0.5	1.6	0.9	-0.2	-1.2
Allergy	0.2	0.5	2.2	0.2	-0.1	0.9	0.2	1.5	0.1	-0.2
Pain all over the body in last month	1.1	1.2	3.0	0.4	1.4	0.6	0.8	1.0	1.2	-1.7
Diabetes (self-reported)	0.2	0.2	0.6	-0.3	-0.4	-0.7	-0.2	-0.8	-0.4	0.3
Hayfever/allergic rhinitis (self-reported)	0.7	0.9	3.4	-1.4	-0.0	0.6	0.4	-0.6	1.8	-0.1
Medication: Ramipril	0.5	0.7	2.4	0.9	0.6	-0.1	1.5	0.7	-0.1	-0.9
Medication: Simvastatin	1.0	1.5	2.6	-0.1	-1.6	-1.4	-1.2	-1.3	-1.4	1.0
Fluid intelligence score	0.1	0.1	0.6	0.0	-0.0	-0.0	-0.8	-0.4	0.4	-0.1
Illnesses of siblings	6.6	9.3	16.7	-2.3	-2.5	-2.4	-4.1	-2.8	-3.4	3.4
Neuroticism score	0.1	0.3	1.0	0.6	-0.7	-0.3	-0.1	0.3	0.4	-1.0
Weight	0.2	0.9	2.7	-0.4	-0.0	-1.2	-1.6	-1.5	0.4	0.1
Impedance of arm (right)	0.2	1.1	2.6	-0.9	-1.3	-0.5	-0.9	-0.6	-1.6	1.1
Arm fat percentage (right)	0.3	1.3	2.4	-1.0	0.5	-1.4	-1.2	-1.6	-0.6	-1.3
Trunk fat-free mass	0.3	1.6	5.0	0.2	-1.0	-1.0	-2.2	-1.6	0.7	1.0
Hip circumference	0.0	0.2	0.6	-0.0	0.2	-0.3	-0.8	-0.7	0.4	0.1
Time employed in main current job	0.3	0.3	0.6	-0.8	0.5	0.6	-0.1	0.7	0.5	-0.7
Alcohol intake versus 10 years previously	1.2	1.8	7.2	-0.9	-1.2	-2.7	0.4	-1.4	-0.4	0.9
Father’s age at death	0.7	1.0	2.4	-0.2	-0.6	1.2	1.1	1.5	-1.2	-0.1
Worrier / anxious feelings	0.1	0.2	1.0	0.2	0.0	-0.3	-0.2	-0.3	0.4	-1.0
Frequency of tiredness / lethargy in last 2 weeks	0.1	0.2	0.4	-0.3	-0.6	0.2	0.5	0.5	-0.5	-0.1
Falls in the last year	1.5	2.0	4.8	0.5	1.5	1.0	1.1	1.9	1.1	-2.2
Hair/balding pattern: Pattern 3	1.1	1.6	2.9	-0.2	1.4	1.2	1.7	1.1	1.5	-1.2
Number of live births	0.5	0.7	2.6	0.3	1.2	-0.1	0.1	0.2	1.6	-0.7
Forced expiratory volume in 1-second (FEV1)	0.6	2.1	4.7	1.2	-1.2	-0.9	-1.9	-1.2	-1.0	2.2
Pulse rate	0.4	0.6	1.7	-1.3	-0.1	-0.9	-1.0	-0.2	-0.6	-0.7
Happiness	0.8	1.0	1.7	-1.3	-1.2	-0.0	-1.3	-0.9	-0.7	1.0
Noisy workplace	0.3	0.4	0.9	0.7	0.2	0.4	1.0	0.6	0.2	-0.8
Qualifications: A levels/AS levels or equivalent	1.0	2.1	4.2	-1.9	-1.1	0.9	-1.1	-0.5	-2.0	1.9
Serious illness, injury or assault of a close relative in last 2 years	1.2	1.4	5.1	1.2	-0.1	0.9	2.3	1.1	0.9	-0.4
Mouth/teeth dental problems: Dentures	0.2	0.3	1.4	-0.1	-1.2	-0.1	0.5	0.2	0.5	-0.1
Asthma	1.5	2.9	5.7	0.7	1.4	1.2	2.1	1.1	2.4	-2.2
Medication: Ibuprofen (e.g. Nurofen)	0.2	0.3	0.5	0.6	-0.6	0.5	0.3	-0.6	0.7	0.3
Medication: Cholesterol lowering	2.5	3.8	7.0	-0.1	-0.9	-2.3	-2.4	-2.6	-2.6	1.2
Depression (self-reported)	0.8	0.9	2.7	0.4	1.6	0.8	0.8	0.4	-0.0	-1.5
Medication: Lansoprazole	1.6	1.8	9.1	3.0	0.6	0.3	0.9	0.4	1.4	-0.1
Prospective memory result	0.3	0.4	1.4	-0.6	-0.9	-0.3	-0.1	-0.2	0.4	1.2
Lung cancer (father)	0.4	0.5	1.2	-0.1	0.6	1.1	0.9	0.6	0.8	-0.3
Illnesses of mother	0.6	0.7	3.2	-0.5	0.7	-0.4	-1.0	0.0	-1.8	0.1
Forced expiratory volume in 1-second (FEV1), Best measure	0.8	2.5	6.7	0.4	-2.3	-0.8	-1.4	-1.3	-1.1	2.6
Pulse wave Arterial Stiffness index	2.1	2.5	5.9	0.1	-1.5	-0.8	-2.4	-1.9	-1.3	1.9
Impedance of arm (left)	0.1	0.6	1.3	-0.8	-0.4	0.7	0.5	0.8	-1.1	0.8
Arm fat mass (right)	0.3	1.2	2.7	-0.9	0.1	-1.4	-1.5	-1.6	-0.1	-0.8
Trunk predicted mass	0.3	1.6	5.1	0.1	-1.0	-1.0	-2.3	-1.6	0.7	1.1
Standing height	0.3	3.1	8.6	-0.6	-2.1	-0.2	-2.6	-1.1	0.3	2.9
Length of working week for main job	1.0	1.2	7.1	-2.7	-0.6	-0.2	0.5	-0.3	0.5	-0.1
Exposure to tobacco smoke at home	0.2	0.2	0.7	0.4	-0.8	0.5	0.4	0.5	-0.1	0.1
Breastfed as a baby	1.5	1.8	5.6	1.7	-2.4	0.7	0.9	0.2	0.6	1.6
Tense / ‘highly strung’	0.8	1.3	2.3	1.0	0.5	1.5	1.2	1.3	1.0	-1.2
Seen doctor (GP) for nerves, anxiety, tension or depression	0.2	0.3	1.2	-0.4	0.6	-0.4	-0.6	-0.1	-0.2	-1.1
Hair/balding pattern: Pattern 4	0.2	0.5	2.1	0.0	-0.3	0.3	-0.7	0.1	-1.4	-0.8
Birth weight of first child	1.7	3.2	5.0	-2.2	-1.9	-1.3	-2.2	-2.0	-1.3	1.1
Peak expiratory flow (PEF)	1.2	2.9	7.2	1.0	-1.5	-1.0	-2.1	-1.5	-1.5	2.7
Pulse wave reflection index	0.3	0.4	1.6	1.3	0.2	0.8	-0.5	-0.2	-0.4	-0.3
Ever highly irritable/argumentative for 2 days	1.0	1.2	2.7	-1.6	-0.9	-1.6	-0.9	-1.0	0.7	0.4
Loud music exposure frequency	0.1	0.1	0.4	0.6	-0.6	-0.1	0.3	0.4	-0.1	0.1
Qualifications: O levels/GCSEs or equivalent	1.0	1.6	3.8	-1.4	-1.4	-0.5	-0.8	-0.8	-1.2	2.0
Mouth/teeth dental problems: Bleeding gums	0.3	0.4	1.4	0.0	-0.2	-0.5	0.8	0.0	0.8	-1.2
Blood clot in the leg (DVT)	0.4	0.5	1.5	-1.2	0.0	0.5	-0.1	-0.8	0.1	0.9
Medication: Paracetamol	2.5	4.2	8.1	-0.5	-1.8	-2.8	-2.5	-2.9	-1.2	1.5
Headache pain in last month	0.4	0.7	2.0	0.3	0.3	0.8	1.4	0.4	1.2	-0.6
Medication for cholesterol, blood pressure or diabetes	0.1	0.2	0.5	0.0	-0.6	0.3	0.3	0.5	0.7	0.4
Glaucoma (self-reported)	0.2	0.2	0.7	0.8	0.2	0.1	-0.8	-0.2	0.4	-0.1
Gout (self-reported)	1.7	2.3	9.4	-0.6	-0.0	0.2	2.1	0.6	3.1	-1.3
Hypothyroidism/myxoedema (self-reported)	0.5	1.0	2.1	-0.1	0.8	1.3	1.0	0.8	1.5	-0.8
Medication: Amlodipine	0.4	0.5	1.6	0.3	-1.0	-0.3	0.4	-0.1	1.3	-0.7
Medication: Ventolin 100micrograms inhaler	0.2	0.3	0.8	0.2	0.8	0.4	0.4	-0.4	0.9	-0.4
Birth weight	9.2	20.0	38.4	-1.0	-5.3	-3.0	-5.5	-5.1	-2.6	6.2
Chronic bronchitis/emphysema (mother)	3.9	4.6	7.3	0.3	2.7	2.0	2.6	1.7	1.9	-2.7
High blood pressure (siblings)	4.1	5.9	13.2	1.7	1.9	1.6	3.6	2.5	2.7	-2.3
Forced vital capacity (FVC), Best measure	0.2	0.7	2.1	0.8	-1.2	0.5	-0.4	0.2	0.1	1.5
Body fat percentage	0.2	0.6	1.3	-0.7	0.8	-0.9	-0.4	-0.8	-0.4	-1.1
Leg fat percentage (right)	0.2	0.6	2.2	-0.0	1.1	-0.6	0.5	0.1	-0.0	-1.5
Arm fat-free mass (right)	0.1	0.5	1.8	0.2	-0.1	-0.5	-1.3	-0.6	1.0	0.5
Exposure to tobacco smoke outside home	0.3	0.4	1.0	-0.5	0.7	-0.3	-1.0	0.3	-0.1	-0.8
Comparative body size at age 10	1.3	3.6	9.2	-0.6	-0.7	-1.0	-3.0	-1.9	-2.9	1.4
Number of full brothers	0.3	0.3	1.0	-0.6	0.4	-0.5	-0.4	-0.4	1.0	-0.2
Worry too long after embarrassment	0.3	0.6	1.3	0.3	-1.1	-0.6	0.2	-0.9	-1.1	0.4
Seen a psychiatrist for nerves, anxiety, tension or depression	1.0	1.3	2.4	-1.6	1.3	-0.3	-1.5	-0.7	-1.4	-0.1
Wheeze or whistling in the chest in last year	1.4	2.5	4.5	-2.0	1.0	-0.9	1.9	0.4	1.9	-2.1
Number of children fathered	0.8	0.9	2.7	1.7	0.4	-0.0	1.4	0.6	1.0	-0.5
Reason for reducing amount of alcohol drunk: Health precaution	0.5	0.6	1.7	1.3	0.7	1.2	0.4	0.8	-0.1	0.1
Age at first live birth	0.4	0.7	2.8	0.6	-0.3	0.8	-1.0	0.2	-1.7	0.3
Pulse wave peak to peak time	1.8	2.2	5.1	-0.3	1.3	0.8	2.3	1.8	1.2	-1.7
Health satisfaction	0.3	0.4	1.0	-1.0	-0.4	-0.2	-0.2	-0.5	-0.0	1.0
Shortness of breath walking on level ground	1.1	1.3	3.3	-1.6	-0.3	-1.8	-0.4	-0.8	0.2	-1.4
Qualifications: College or University degree	0.7	2.2	7.9	-0.0	-0.2	2.8	1.4	1.3	2.0	0.5
Eye problems/disorders: None of the above	1.3	1.5	3.2	0.2	1.8	1.0	1.6	1.1	0.1	-1.5
Mouth/teeth dental problems: Loose teeth	0.7	0.8	1.9	0.3	1.4	-0.2	1.4	-0.5	1.0	-0.9
Emphysema/chronic bronchitis	0.3	0.3	1.4	-0.3	-0.1	-0.1	0.1	0.8	0.3	-1.2
Medication for pain relief, constipation, heartburn	0.2	0.4	1.3	-1.1	0.6	0.7	0.1	0.8	-0.3	-0.1
Neck or shoulder pain in last month	0.2	0.2	0.9	-0.2	-0.5	-0.9	-0.0	-0.6	-0.0	0.2
Medication: Blood pressure	0.3	0.5	1.2	-0.1	1.0	-0.2	0.9	0.4	-0.0	-1.1
Angina (self-reported)	0.6	0.7	1.6	0.5	1.0	1.2	0.8	1.3	0.5	-0.3
Migraine (self-reported)	0.4	0.5	2.0	0.0	-0.3	0.3	0.8	-0.1	-1.4	0.9
Medication: Ibuprofen	0.2	0.2	0.5	-0.1	-0.7	0.2	0.1	-0.7	0.3	0.7
Medication: Allopurinol	1.5	2.0	6.1	0.1	0.3	0.9	2.5	1.0	2.0	-1.5
Medication: Omeprazole	0.2	0.3	1.5	-1.2	-0.4	0.1	0.1	0.2	0.5	-0.1
Medication: Seretide 50 evohaler	0.5	0.6	2.0	0.1	-0.8	1.0	0.1	-0.5	1.4	0.2
Mean time to correctly identify matches	0.2	0.3	1.1	0.5	0.2	0.3	-0.6	-1.1	-0.1	0.3
Heart disease (mother)	2.0	2.4	5.1	-1.4	-1.4	-2.3	-1.4	-1.5	-1.3	1.4
Reproduciblity of spirometry measurement using ERS/ATS criteria	0.5	0.6	1.3	1.1	0.5	-0.7	0.8	0.5	-0.6	-0.9
Whole body fat mass	0.2	0.8	1.8	-0.9	0.3	-1.2	-1.2	-1.3	-0.3	-0.5
Leg fat mass (right)	0.1	0.5	1.2	-0.6	0.3	-1.1	-0.7	-0.9	0.1	-0.7
Arm predicted mass (right)	0.1	0.6	1.8	0.5	-0.1	-0.3	-1.3	-0.6	1.2	0.5
Pulse rate, automated reading	0.5	1.5	4.8	-1.0	-0.4	-2.2	-1.3	-1.6	-0.8	0.5
Alcohol intake frequency.	0.9	2.1	5.8	0.9	1.9	0.3	1.1	1.1	1.4	-2.4
Comparative height size at age 10	0.2	1.0	4.3	0.2	-2.1	-0.4	-0.4	-0.9	-0.1	1.2
Number of full sisters	0.3	0.4	1.1	0.7	1.1	-0.4	-0.3	-0.5	-0.1	-0.8
Suffer from ‘nerves’	0.2	0.3	0.8	0.9	0.5	-0.0	0.2	0.7	-0.1	-0.9
Overall health rating	0.4	1.0	2.8	0.2	1.0	-0.7	1.7	0.8	-0.0	-1.3
Chest pain or discomfort	1.3	1.8	4.4	-0.5	1.9	-0.1	1.6	0.7	1.2	-2.1
Had major operations	1.1	1.3	6.0	0.5	-0.1	0.9	1.0	0.8	2.4	0.1
Age at last live birth	0.3	0.4	1.7	0.2	-0.3	1.3	-0.3	0.6	-0.0	0.6
Family relationship satisfaction	0.5	0.6	1.5	-0.1	-0.7	-1.2	-0.8	-0.9	0.7	0.7
Leg pain on walking	1.0	1.3	2.4	1.1	0.8	-0.7	1.5	0.3	1.5	-1.4
Qualifications: NVQ or HND or HNC or equivalent	1.6	1.9	7.3	-0.7	-0.3	-1.2	-1.8	-0.6	-2.7	-0.3
Commuting to job workplace: Car/motor vehicle	2.3	2.6	5.9	1.5	1.3	0.6	1.5	1.7	2.4	-1.6
Illness, injury, bereavement, stress in last 2 years	2.7	3.3	6.6	-0.9	-2.6	-0.5	-2.2	-2.0	-0.8	2.4
Medication: Aspirin	0.2	0.2	0.8	0.4	0.0	0.3	0.5	0.4	-0.9	0.0
Supplements: Vitamin C	0.7	0.9	2.2	-1.5	0.7	-0.5	-0.3	-0.9	1.2	-0.9
Knee pain experienced in last month	1.6	2.5	7.5	-0.0	1.1	-2.7	1.3	-0.8	2.2	-1.3
Hypertension (Self-reported)	0.4	1.1	5.9	2.4	0.4	-0.0	0.5	0.2	0.9	-0.6
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported)	0.1	0.1	0.3	-0.1	0.1	-0.2	-0.3	-0.1	-0.6	-0.4
Illnesses of father: Heart disease	1.0	1.4	2.7	0.7	-1.4	-0.9	-1.6	-1.5	-0.6	1.1
Illnesses of siblings: Diabetes	3.0	3.7	6.4	2.0	2.1	2.1	2.1	1.5	0.7	-2.5
Smoking status: Previous	1.5	2.2	5.2	0.6	0.8	0.4	2.1	0.9	2.1	-2.3
Forced expiratory volume in 1-second (FEV1), predicted	0.4	0.9	3.8	1.2	0.2	1.0	0.4	2.0	0.3	0.1
Whole body fat-free mass	0.3	1.6	5.3	-0.1	-0.9	-1.1	-2.3	-1.7	0.6	0.8
Leg fat-free mass (right)	0.4	2.0	5.9	-0.6	-0.7	-1.6	-2.4	-2.0	0.3	0.7
Arm fat percentage (left)	0.2	0.7	1.6	-1.0	0.8	-0.9	-0.5	-0.9	-0.4	-1.3
Average weekly red wine intake	0.5	0.7	4.4	-2.1	0.1	0.3	-0.6	-0.3	0.2	-0.1
Handedness (chirality/laterality): Left-handed	0.8	1.0	3.8	-0.8	1.0	-0.3	-0.1	0.4	1.1	-1.9
Mood swings	0.2	0.4	0.9	1.0	0.6	0.1	0.4	0.9	0.1	-0.3
Loneliness, isolation	0.1	0.1	0.2	0.1	0.5	-0.2	-0.2	-0.5	-0.1	-0.0
Long-standing illness, disability or infirmity	0.5	0.8	2.6	0.0	1.0	-0.3	1.6	0.4	0.9	-0.9
Ever had bowel cancer screening	1.0	1.1	2.4	-0.5	-1.1	-1.6	-0.4	-1.3	-0.8	1.3
Diabetes diagnosed by doctor	0.1	0.1	0.2	-0.5	0.2	-0.4	0.1	-0.3	-0.2	-0.4
Ever had stillbirth, spontaneous miscarriage or termination	0.9	1.0	3.1	-0.5	1.8	-1.3	-0.8	-0.5	0.6	-0.7
Friendships satisfaction	0.3	0.4	1.0	-0.8	-0.1	-1.0	-0.5	-0.7	-0.6	-0.1
Qualifications: nursing, teaching	0.6	0.9	4.3	-2.1	-1.0	-0.2	-0.6	-0.3	-0.2	0.8
Commuting to job workplace: Walk	2.0	2.1	4.6	-0.5	-1.4	-0.4	-1.5	-1.8	-1.6	2.1
Eye problems/disorders: Cataract	1.0	1.2	2.3	-0.2	-1.4	-1.5	-1.1	-0.9	-0.9	0.9
Mouth/teeth dental problems: Mouth ulcers	0.1	0.2	0.8	-0.1	0.3	-0.1	-0.9	-0.4	-0.0	0.3
Medication for cholesterol	0.5	0.8	2.6	-1.1	-0.7	0.4	-0.3	-0.8	-0.1	1.6
Medication: Laxatives (e.g. Dulcolax, Senokot)	1.6	1.9	6.0	1.2	-2.4	-1.3	-0.6	-1.2	-0.3	1.4
Back pain experienced in last month	0.5	0.7	2.4	0.4	-0.2	-1.4	-0.1	-0.2	-1.5	0.3
Mineral and other dietary supplements	2.5	3.4	9.2	-0.2	1.5	2.1	0.7	2.5	-1.0	-3.0
Breast cancer (self-reported)	0.7	0.9	2.6	-1.6	-0.5	-0.6	0.3	-0.3	-1.4	0.9
Asthma (self-reported)	1.6	3.2	6.5	0.6	1.4	1.2	2.5	1.2	2.5	-2.2
Osteoporosis (self-reported)	1.0	1.3	5.0	-0.7	-0.4	1.1	2.2	1.2	0.4	0.4
Osteoarthritis (self-reported)	0.8	1.0	4.6	0.5	0.3	0.5	1.3	0.1	2.1	-0.5
Medication: Aspirin	0.2	0.2	0.5	0.6	-0.1	0.7	0.6	0.6	-0.0	0.2
Medication: Gliclazide	2.3	2.6	4.9	0.9	-0.7	-1.5	-2.0	-2.2	-1.7	1.6
Illnesses of father: None of the above (group 1)	0.5	0.6	2.0	-1.4	0.1	0.1	1.0	0.7	-0.9	-0.5
Smoking status: Current	0.5	0.7	1.4	-0.5	0.8	-0.5	-1.2	-0.6	-1.0	-1.1
Forced expiratory volume in 1-second (FEV1), predicted percentage	0.5	1.0	2.3	0.8	-1.5	1.2	-0.3	0.1	0.6	1.5
Whole body water mass	0.3	1.5	4.9	0.0	-0.9	-1.0	-2.2	-1.6	0.8	0.7
Leg predicted mass (right)	0.4	2.1	6.3	-0.7	-0.8	-1.6	-2.5	-2.1	0.3	0.8
Arm fat mass (left)	0.2	0.7	1.2	-0.7	0.6	-0.9	-0.9	-1.1	0.1	-1.0
Number of self-reported non-cancer illnesses	0.5	0.9	3.1	-0.0	-0.5	0.3	1.3	-0.9	1.8	0.6
Average weekly champagne plus white wine intake	1.0	1.3	4.4	-0.1	-0.6	2.1	-1.7	0.4	0.6	1.2
Miserableness	0.4	0.7	2.1	-0.5	-0.6	-1.4	-1.0	-0.5	-0.7	0.1
Guilty feelings	0.3	0.5	1.2	-0.2	-1.1	-1.0	-0.1	-0.9	0.2	-0.1
Wears glasses or contact lenses	0.6	0.6	1.8	-1.3	-0.4	0.1	-0.3	-0.8	0.0	1.3
Ever taken oral contraceptive pill	1.2	1.3	3.6	0.5	-0.6	-1.8	-1.3	-1.9	0.2	0.2
Hearing aid user	0.5	0.5	1.8	-0.4	0.5	-0.4	-1.4	-0.5	0.1	1.1
Mother’s age at death	0.4	0.5	1.1	-0.0	-1.1	-0.9	0.6	-0.7	0.7	0.1
Financial situation satisfaction	0.5	0.6	1.8	1.1	-0.3	0.7	0.6	0.6	1.3	0.2
Tinnitus: Yes, now most or all of the time	1.5	1.7	5.6	0.4	0.3	-1.2	-1.9	-1.0	-2.4	-0.1
Commuting to job workplace: Public transport	1.0	1.2	3.4	1.0	-1.8	0.8	-0.8	-0.1	0.0	1.6
Eye problems/disorders: Glaucoma	0.2	0.3	1.2	-0.1	0.5	1.1	-0.3	0.4	0.6	-0.3
Medication: Blood pressure	0.4	0.8	3.0	1.7	0.4	-0.2	0.6	0.6	0.8	-1.1
Pain type(s) experienced in last month: Hip pain	0.6	0.7	2.5	0.8	0.7	-1.6	0.6	-0.8	-0.3	-0.3
Supplements: Fish oil (including cod liver oil)	1.1	1.4	4.4	0.2	-0.2	-1.4	-0.7	-1.5	0.6	2.1
High cholesterol (Self-reported)	0.3	0.5	1.1	-0.7	-0.4	-0.9	-0.9	-1.1	-0.4	0.2
Medication: Bendroflumethiazide	0.6	1.0	3.2	0.6	0.6	-1.8	0.7	-0.5	-0.1	-1.4
Medication: Paracetamol	2.0	3.0	6.0	-0.6	-1.6	-2.2	-2.3	-2.5	-0.9	1.2
Medication: Lisinopril	0.4	0.5	1.5	1.2	0.2	-0.7	0.2	0.1	-1.1	-0.5
Medication: Atorvastatin	0.1	0.2	0.4	-0.0	-0.1	-0.4	-0.6	-0.3	0.3	0.6
Illnesses of father: High blood pressure	0.6	0.8	1.5	0.9	-0.7	1.2	0.9	1.1	0.8	-0.0
Alcohol drinker status: Never	2.0	2.4	5.2	1.3	2.2	2.3	0.9	1.2	0.4	-1.7
Ever smoked	0.4	0.6	3.4	-0.2	0.5	-0.1	0.6	-0.2	0.5	-1.8
Basal metabolic rate	0.2	1.3	4.5	-0.2	-0.7	-1.1	-2.1	-1.6	0.7	0.5
Leg fat percentage (left)	0.3	1.0	3.1	-0.1	1.7	-0.6	0.6	0.3	-0.3	-1.7
Arm fat-free mass (left)	0.2	0.9	2.9	0.4	-0.1	-0.7	-1.7	-1.0	1.2	0.1
Number of operations (self-reported)	0.2	0.4	0.8	0.3	0.9	0.7	0.6	0.9	-0.2	0.0
Average weekly beer plus cider intake	0.3	0.5	2.0	-0.6	-1.4	-0.5	-0.5	-0.4	0.4	0.5
Irritability	0.4	0.7	3.1	-0.1	-0.7	-1.8	-0.1	-0.8	-0.4	-0.6
Risk taking	2.7	3.9	10.8	0.2	1.9	1.9	1.3	1.4	3.3	-2.3
Ever had prostate specific antigen (PSA) test	0.3	0.4	1.4	-1.2	-0.2	-0.7	-0.5	-0.5	0.3	-0.0
Fractured/broken bones in last 5 years	1.5	1.9	3.0	0.2	-1.7	-1.0	-1.6	-0.9	-1.7	1.7
Age started oral contraceptive pill	0.3	0.4	1.1	0.7	-1.0	0.9	-0.3	0.2	0.0	0.3
Diastolic blood pressure, automated reading	0.3	0.9	3.1	-0.4	0.0	-0.6	-1.8	-0.7	-1.1	0.9
Ever depressed for a whole week	4.2	5.2	9.8	-1.0	-1.2	-3.1	-3.0	-2.8	-2.2	1.5
Unable to work because of sickness or disability	1.6	2.0	4.8	1.2	1.6	0.2	0.8	1.1	1.9	-2.2
Commuting to job workplace: Cycle	0.8	1.0	5.6	-2.4	-0.4	-0.4	0.6	-0.1	-0.1	-0.8
Myopia	0.1	0.1	0.4	0.1	-0.3	-0.4	-0.2	-0.6	-0.4	-0.1
Vascular/heart problems diagnosed by doctor	0.3	0.7	4.4	-2.1	-0.0	0.3	-0.4	-0.1	-0.4	0.5
Cholesterol lowering medication	0.3	0.4	1.8	0.1	-1.4	-0.8	-0.3	-0.2	0.2	0.4
Medication: Omeprazole (e.g. Zanprol)	0.2	0.2	0.9	-0.4	-0.5	-0.3	0.2	0.1	1.0	0.0
Pain experienced in last month	1.0	1.7	5.2	-1.1	-1.6	1.1	-2.3	-0.6	-0.4	1.1
Supplements: Calcium	0.4	0.5	1.5	0.5	-0.5	-0.4	-0.4	-0.5	0.9	1.2
Basal cell carcinoma (self-reported)	0.3	0.4	0.8	0.4	0.9	-0.4	0.8	0.5	0.6	-0.4
Heart attack/myocardial infarction (self-reported)	0.8	1.0	2.3	-1.5	0.9	-0.3	1.5	0.9	-0.1	-1.0
Deep venous thrombosis (DVT) (self-reported)	0.4	0.6	1.7	-1.3	-0.1	0.2	-0.2	-1.0	-0.1	1.1
Heart disease (siblings)	2.9	3.6	6.2	0.7	1.4	1.3	2.2	2.2	2.1	-2.5
Alcohol drinker status: Previous	0.3	0.3	0.8	0.6	-0.3	0.4	0.6	0.4	0.2	-0.9
Pack years of smoking	0.6	0.9	2.3	1.0	1.5	0.3	0.3	0.4	-0.7	-1.5
Impedance of whole body	0.2	1.0	2.7	-0.6	0.1	1.2	1.1	1.7	-0.8	0.3
Leg fat mass (left)	0.1	0.6	1.4	-0.6	0.7	-1.2	-0.7	-0.8	-0.1	-0.8
Arm predicted mass (left)	0.2	1.1	4.3	0.2	-0.3	-1.0	-2.1	-1.3	0.9	0.3