[Hub]/) : Traits : Suffer from 'nerves' : ← →

chr16:27,691,641-29,595,483

Best TWAS P=3.67e-09 · Best GWAS P=1.07e-08 conditioned to 0.0825

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	CommonMind	Brain Pre-frontal Cortex	NFATC2IP	0.05	0.03	blup	183	0.04	1.3e-05	5.3	5.6	2.4e-08	0.82	0.05	0.95	FALSE
2	CommonMind	Brain Pre-frontal Cortex	SH2B1	0.05	0.04	lasso	2	0.03	7.4e-05	5.3	5.3	9.3e-08	0.81	0.05	0.91	FALSE
3	GTEx	Adipose Subcutaneous	SH2B1	0.05	0.09	lasso	1	0.08	2.7e-07	5.3	-5.3	9.1e-08	-0.81	0.05	0.95	FALSE
4	GTEx	Adipose Subcutaneous	SULT1A2	0.08	0.13	lasso	4	0.12	4.2e-10	5.5	5.5	3.3e-08	0.94	0.02	0.98	FALSE
5	GTEx	Adipose Visceral Omentum	RP11-1348G14.4	0.11	0.08	lasso	5	0.07	1.1e-04	5.3	-5.6	2.6e-08	-0.90	0.03	0.97	FALSE
6	GTEx	Adrenal Gland	SULT1A2	0.44	0.40	lasso	16	0.47	5.3e-19	5.3	5.5	3.0e-08	0.91	0.04	0.96	FALSE
7	GTEx	Adrenal Gland	EIF3CL	0.24	0.07	lasso	7	0.08	6.4e-04	5.5	5.5	2.9e-08	0.82	0.04	0.95	FALSE
8	GTEx	Artery Aorta	NUPR1	0.09	0.01	lasso	5	0.04	2.5e-03	4.6	-5.6	1.7e-08	-0.75	0.12	0.67	FALSE
9	GTEx	Artery Aorta	TUFM	0.12	0.12	enet	8	0.17	1.1e-09	5.5	5.4	7.8e-08	0.90	0.03	0.97	FALSE
10	GTEx	Artery Aorta	RP11-1348G14.4	0.13	0.11	enet	17	0.14	5.0e-08	5.5	-5.2	2.5e-07	-0.88	0.03	0.97	FALSE
11	GTEx	Artery Aorta	MIR4721	0.07	0.10	lasso	3	0.08	3.1e-05	5.5	5.6	2.6e-08	0.85	0.03	0.97	FALSE
12	GTEx	Artery Tibial	NUPR1	0.12	0.14	lasso	10	0.16	1.0e-12	4.6	-5.2	1.7e-07	-0.91	0.08	0.92	FALSE
13	GTEx	Artery Tibial	SULT1A2	0.13	0.17	lasso	7	0.19	1.1e-14	5.3	5.3	8.7e-08	0.92	0.04	0.96	FALSE
14	GTEx	Artery Tibial	EIF3CL	0.05	0.03	lasso	2	0.04	8.3e-04	5.6	5.8	4.8e-09	0.87	0.03	0.96	FALSE
15	GTEx	Artery Tibial	MIR4721	0.06	0.15	lasso	3	0.14	2.6e-11	5.5	5.4	6.5e-08	0.81	0.02	0.98	FALSE
16	GTEx	Brain Cerebellar Hemisphere	RP11-1348G14.4	0.11	0.14	lasso	2	0.17	4.8e-05	5.3	-5.2	2.2e-07	-0.80	0.05	0.90	FALSE
17	GTEx	Brain Cerebellum	SULT1A1	0.29	0.15	enet	18	0.15	4.2e-05	5.2	-5.3	1.1e-07	-0.90	0.08	0.88	FALSE
18	GTEx	Brain Hypothalamus	EIF3CL	0.15	0.04	lasso	4	0.02	1.2e-01	5.5	5.8	8.5e-09	0.90	0.03	0.71	FALSE
19	GTEx	Breast Mammary Tissue	NFATC2IP	0.10	0.02	lasso	5	0.04	4.6e-03	4.9	5.5	4.9e-08	0.82	0.08	0.84	FALSE
20	GTEx	Breast Mammary Tissue	SH2B1	0.06	0.07	lasso	12	0.06	4.4e-04	4.9	-5.3	1.4e-07	-0.89	0.05	0.87	FALSE
21	GTEx	Breast Mammary Tissue	EIF3C	0.06	0.01	lasso	2	0.00	2.8e-01	5.3	5.2	2.1e-07	0.78	0.04	0.77	FALSE
22	GTEx	Breast Mammary Tissue	SULT1A2	0.08	0.06	lasso	2	0.08	9.8e-05	5.7	5.6	2.3e-08	0.92	0.02	0.97	FALSE
23	GTEx	Breast Mammary Tissue	RP11-1348G14.4	0.13	0.17	lasso	6	0.16	2.3e-08	4.8	-5.3	1.1e-07	-0.88	0.09	0.91	FALSE
24	GTEx	Breast Mammary Tissue (Male)	EIF3CL	0.13	0.09	lasso	4	0.06	2.1e-02	5.3	5.4	7.2e-08	0.82	0.03	0.49	FALSE
25	GTEx	Breast Mammary Tissue (Female)	SH2B1	0.09	0.05	enet	5	0.01	1.8e-01	5.5	-5.3	1.2e-07	-0.93	0.05	0.82	FALSE
26	GTEx	Breast Mammary Tissue (Female)	SULT1A1	0.13	0.07	lasso	4	0.08	2.1e-03	4.8	-5.7	1.4e-08	-0.91	0.03	0.77	FALSE
27	GTEx	Breast Mammary Tissue (Female)	SULT1A2	0.10	0.08	lasso	2	0.05	1.1e-02	5.7	5.7	1.1e-08	0.92	0.02	0.78	FALSE
28	GTEx	Breast Mammary Tissue (Female)	RP11-1348G14.4	0.19	0.15	enet	16	0.15	3.0e-05	4.8	-5.5	3.6e-08	-0.87	0.05	0.94	FALSE
29	GTEx	Cells Transformed fibroblasts	TUFM	0.04	0.07	lasso	4	0.06	4.0e-05	5.5	5.3	1.0e-07	0.83	0.03	0.97	FALSE
30	GTEx	Cells Transformed fibroblasts	SULT1A1	0.05	0.05	enet	9	0.04	4.5e-04	5.5	-5.7	1.0e-08	-0.89	0.04	0.96	FALSE
31	GTEx	Cells Transformed fibroblasts	EIF3CL	0.07	0.05	lasso	4	0.03	2.0e-03	5.4	5.1	2.8e-07	0.80	0.04	0.94	FALSE
32	GTEx	Colon Sigmoid	TUFM	0.14	0.26	lasso	6	0.20	9.0e-08	5.4	5.4	5.4e-08	0.84	0.03	0.97	FALSE
33	GTEx	Colon Sigmoid	RP11-1348G14.4	0.10	0.10	lasso	3	0.03	3.1e-02	5.3	-5.4	8.5e-08	-0.82	0.04	0.90	FALSE
34	GTEx	Colon Sigmoid	MIR4721	0.11	0.15	lasso	3	0.16	4.0e-06	5.4	5.6	1.7e-08	0.87	0.03	0.96	FALSE
35	GTEx	Colon Transverse	NFATC2IP	0.07	0.08	lasso	6	0.09	3.5e-05	5.5	5.4	5.3e-08	0.75	0.06	0.92	FALSE
36	GTEx	Colon Transverse	TUFM	0.24	0.20	lasso	3	0.17	1.3e-08	5.5	5.4	5.7e-08	0.81	0.02	0.98	FALSE
37	GTEx	Colon Transverse	ATP2A1	0.07	0.03	lasso	2	0.03	2.1e-02	5.4	5.5	4.6e-08	0.81	0.04	0.77	FALSE
38	GTEx	Esophagus Gastroesophageal Junction	SH2B1	0.12	0.07	lasso	5	0.14	1.4e-05	5.1	-5.8	5.0e-09	-0.81	0.04	0.88	FALSE
39	GTEx	Esophagus Mucosa	SH2B1	0.09	0.03	lasso	4	0.03	4.9e-03	5.3	-5.9	3.7e-09	-0.79	0.05	0.94	TRUE
40	GTEx	Esophagus Mucosa	SULT1A2	0.12	0.12	lasso	4	0.10	1.9e-07	4.9	5.2	2.5e-07	0.92	0.08	0.92	FALSE
41	GTEx	Esophagus Mucosa	EIF3CL	0.10	0.06	lasso	6	0.07	3.5e-05	4.6	5.5	4.6e-08	0.89	0.03	0.96	FALSE
42	GTEx	Esophagus Mucosa	RP11-1348G14.4	0.04	0.05	lasso	3	0.03	2.4e-03	5.3	-5.4	6.9e-08	-0.81	0.04	0.89	FALSE
43	GTEx	Esophagus Muscularis	NUPR1	0.06	0.04	lasso	3	0.05	8.3e-04	4.9	-5.1	2.8e-07	-0.91	0.07	0.91	FALSE
44	GTEx	Esophagus Muscularis	SH2B1	0.06	0.03	enet	21	0.06	1.9e-04	5.3	-5.2	2.1e-07	-0.79	0.04	0.94	FALSE
45	GTEx	Esophagus Muscularis	TUFM	0.07	0.07	lasso	3	0.08	1.1e-05	5.5	5.3	1.0e-07	0.82	0.03	0.97	FALSE
46	GTEx	Esophagus Muscularis	SULT1A2	0.19	0.22	lasso	7	0.23	3.3e-14	5.5	5.2	1.7e-07	0.91	0.07	0.93	FALSE
47	GTEx	Heart Left Ventricle	SH2B1	0.04	0.07	lasso	1	0.07	2.2e-04	5.4	-5.4	6.0e-08	-0.94	0.04	0.88	FALSE
48	GTEx	Heart Left Ventricle	SULT1A2	0.14	0.22	lasso	10	0.24	3.2e-13	4.9	5.4	8.0e-08	0.94	0.04	0.96	FALSE
49	GTEx	Heart Left Ventricle	EIF3CL	0.06	0.05	lasso	4	0.03	1.5e-02	5.3	5.1	2.9e-07	0.86	0.05	0.94	FALSE
50	GTEx	Lung	TUFM	0.15	0.14	lasso	2	0.12	1.7e-09	5.5	5.5	4.0e-08	0.82	0.02	0.98	FALSE
51	GTEx	Lung	RP11-1348G14.4	0.11	0.12	lasso	7	0.13	2.4e-10	5.5	-5.4	8.2e-08	-0.86	0.03	0.97	FALSE
52	GTEx	Muscle Skeletal	SULT1A1	0.10	0.04	enet	20	0.05	7.5e-06	5.7	-5.5	4.2e-08	-0.74	0.02	0.97	FALSE
53	GTEx	Muscle Skeletal	SULT1A2	0.13	0.18	enet	17	0.19	1.1e-18	4.6	5.2	2.5e-07	0.90	0.29	0.71	FALSE
54	GTEx	Muscle Skeletal	RP11-1348G14.4	0.08	0.05	lasso	6	0.05	1.7e-05	5.1	-5.3	1.1e-07	-0.92	0.03	0.97	FALSE
55	GTEx	Nerve Tibial	TUFM	0.12	0.18	lasso	3	0.20	5.2e-14	5.5	5.5	5.1e-08	0.80	0.02	0.98	FALSE
56	GTEx	Nerve Tibial	SULT1A2	0.17	0.30	lasso	11	0.31	3.5e-22	5.5	5.3	1.2e-07	0.94	0.02	0.98	FALSE
57	GTEx	Nerve Tibial	RP11-1348G14.4	0.09	0.09	lasso	5	0.13	2.4e-09	5.5	-5.3	1.4e-07	-0.90	0.03	0.97	FALSE
58	GTEx	Ovary	TUFM	0.37	0.32	lasso	7	0.31	2.0e-08	5.5	5.3	1.1e-07	0.89	0.03	0.97	FALSE
59	GTEx	Ovary	SULT1A2	0.13	0.04	lasso	5	0.05	2.9e-02	5.7	5.4	7.1e-08	0.86	0.04	0.68	FALSE
60	GTEx	Ovary	RP11-22P6.2	0.10	0.02	enet	24	0.06	1.3e-02	3.9	-5.2	2.1e-07	-0.71	0.05	0.70	FALSE
61	GTEx	Ovary	MIR4721	0.24	0.23	lasso	3	0.23	2.3e-06	5.5	5.6	2.2e-08	0.95	0.03	0.94	FALSE
62	GTEx	Pancreas	TUFM	0.09	0.09	lasso	7	0.11	2.0e-05	5.5	5.2	1.6e-07	0.90	0.04	0.96	FALSE
63	GTEx	Pituitary	ATP2A1	0.11	0.14	lasso	2	0.10	1.4e-03	5.3	5.3	8.9e-08	0.81	0.04	0.77	FALSE
64	GTEx	Prostate	RP11-1348G14.4	0.15	0.13	lasso	4	0.16	8.7e-05	5.5	-5.7	1.2e-08	-0.88	0.03	0.94	FALSE
65	GTEx	Skin Not Sun Exposed Suprapubic	TUFM	0.29	0.28	lasso	3	0.24	1.9e-13	5.5	5.4	8.2e-08	0.82	0.02	0.98	FALSE
66	GTEx	Skin Not Sun Exposed Suprapubic	SULT1A2	0.06	0.10	lasso	1	0.09	1.2e-05	5.5	5.5	3.2e-08	0.94	0.02	0.97	FALSE
67	GTEx	Skin Sun Exposed Lower leg	TUFM	0.25	0.33	lasso	5	0.31	2.5e-26	5.5	5.4	7.4e-08	0.83	0.02	0.98	FALSE
68	GTEx	Skin Sun Exposed Lower leg	SULT1A2	0.07	0.09	lasso	1	0.06	5.0e-06	5.2	5.2	1.6e-07	0.94	0.04	0.96	FALSE
69	GTEx	Skin Sun Exposed Lower leg	MIR4721	0.11	0.14	lasso	4	0.15	3.1e-12	5.5	5.7	1.5e-08	0.91	0.02	0.98	FALSE
70	GTEx	Spleen	SULT1A2	0.17	0.24	lasso	3	0.16	7.8e-05	5.5	5.4	6.7e-08	0.92	0.04	0.95	FALSE
71	GTEx	Stomach	SH2B1	0.05	0.04	enet	17	0.03	1.2e-02	5.3	-5.3	9.0e-08	-0.85	0.05	0.80	FALSE
72	GTEx	Stomach	EIF3C	0.11	0.07	enet	12	0.06	8.6e-04	4.2	5.2	1.9e-07	0.72	0.08	0.84	FALSE
73	GTEx	Stomach	SULT1A2	0.11	0.10	enet	16	0.09	4.7e-05	4.9	5.2	2.3e-07	0.87	0.05	0.94	FALSE
74	GTEx	Stomach	EIF3CL	0.09	0.06	lasso	3	0.12	2.5e-06	-4.0	5.5	4.7e-08	0.76	0.06	0.90	FALSE
75	GTEx	Testis	NUPR1	0.06	0.01	enet	19	0.02	2.8e-02	-4.0	-5.8	6.7e-09	-0.57	0.06	0.55	FALSE
76	GTEx	Testis	SULT1A2	0.10	0.18	lasso	2	0.18	3.4e-08	4.9	5.2	1.5e-07	0.92	0.10	0.90	FALSE
77	GTEx	Thyroid	TUFM	0.11	0.18	lasso	2	0.15	1.5e-11	5.5	5.5	3.9e-08	0.82	0.02	0.98	FALSE
78	GTEx	Thyroid	MIR4721	0.05	0.10	lasso	2	0.09	1.2e-07	5.5	5.5	4.2e-08	0.85	0.03	0.97	FALSE
79	GTEx	Vagina	RP11-1348G14.4	0.19	0.08	lasso	3	0.03	5.6e-02	5.5	-5.5	3.1e-08	-0.91	0.04	0.73	FALSE
80	GTEx	Vagina	MIR4721	0.30	0.11	lasso	6	0.08	7.2e-03	5.5	5.6	1.9e-08	0.78	0.03	0.73	FALSE
81	GTEx	Whole Blood	TUFM	0.27	0.34	lasso	1	0.35	5.2e-33	5.5	5.5	4.3e-08	0.81	0.02	0.98	FALSE
82	GTEx	Whole Blood	SULT1A2	0.19	0.40	lasso	4	0.40	1.2e-38	5.5	5.7	1.4e-08	0.94	0.02	0.98	FALSE
83	GTEx	Whole Blood	MIR4721	0.17	0.25	lasso	3	0.24	9.3e-22	5.5	5.4	6.9e-08	0.81	0.02	0.98	FALSE
84	ROSMAP	Brain Pre-frontal Cortex	NPIPB7	0.20	0.41	lasso	10	0.42	2.1e-58	5.5	-5.7	1.6e-08	-0.96	0.02	0.98	FALSE
85	YFS	Blood	TUFM	0.34	0.59	lasso	4	0.59	2.5e-247	5.5	5.4	6.0e-08	0.82	0.02	0.98	FALSE
86	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EIF3C	0.07	0.03	lasso	3	0.07	1.1e-06	5.5	5.6	2.5e-08	0.80	0.01	0.99	FALSE
87	The Cancer Genome Atlas	Bladder Urothelial Carcinoma	EIF3CL	0.06	0.09	lasso	4	0.09	3.1e-08	5.3	5.2	1.8e-07	0.82	0.01	0.99	FALSE
88	The Cancer Genome Atlas	Breast Invasive Carcinoma	EIF3C	0.03	0.02	lasso	3	0.02	7.2e-06	5.0	5.4	5.2e-08	0.90	0.01	0.99	FALSE
89	The Cancer Genome Atlas	Breast Invasive Carcinoma	EIF3CL	0.08	0.13	blup	18	0.14	4.3e-28	5.3	5.5	3.4e-08	0.84	0.01	0.99	FALSE
90	The Cancer Genome Atlas	Breast Invasive Carcinoma	TUFM	0.01	0.02	lasso	1	0.02	3.6e-04	5.5	5.5	4.5e-08	0.81	0.02	0.97	FALSE
91	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	EIF3C	0.05	0.05	lasso	1	0.05	1.3e-03	5.3	5.3	9.4e-08	0.81	0.00	0.75	FALSE
92	The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	EIF3CL	0.10	0.02	blup	18	0.08	7.7e-05	5.3	5.6	2.2e-08	0.81	0.01	0.98	FALSE
93	The Cancer Genome Atlas	Colon Adenocarcinoma	EIF3C	0.09	0.03	blup	10	0.03	8.6e-03	-3.6	5.3	9.9e-08	0.69	0.01	0.79	FALSE
94	The Cancer Genome Atlas	Colon Adenocarcinoma	EIF3CL	0.21	0.10	lasso	3	0.11	8.9e-07	5.5	5.4	7.2e-08	0.76	0.01	0.99	FALSE
95	The Cancer Genome Atlas	Glioblastoma Multiforme	EIF3CL	0.20	0.24	lasso	6	0.31	3.9e-10	5.3	5.5	3.1e-08	0.83	0.01	0.99	FALSE
96	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	EIF3C	0.06	0.04	blup	10	0.03	2.1e-04	5.3	5.4	7.4e-08	0.83	0.00	0.98	FALSE
97	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	SULT1A2	0.07	0.09	lasso	4	0.07	9.2e-09	5.2	5.3	1.4e-07	0.94	0.00	1.00	FALSE
98	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	EIF3CL	0.08	0.07	lasso	3	0.07	9.4e-05	5.3	5.6	2.3e-08	0.82	0.01	0.97	FALSE
99	The Cancer Genome Atlas	Brain Lower Grade Glioma	EIF3C	0.02	0.03	lasso	1	0.03	1.7e-04	5.5	5.5	4.3e-08	0.81	0.00	0.94	FALSE
100	The Cancer Genome Atlas	Brain Lower Grade Glioma	EIF3CL	0.09	0.13	lasso	2	0.13	2.7e-14	5.3	5.4	5.9e-08	0.80	0.01	0.99	FALSE
101	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	EIF3C	0.05	0.02	blup	10	0.03	1.5e-02	5.5	5.6	1.9e-08	0.82	0.00	0.73	FALSE
102	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	EIF3CL	0.19	0.18	enet	6	0.18	5.6e-09	5.5	5.4	5.4e-08	0.82	0.01	0.99	FALSE
103	The Cancer Genome Atlas	Lung Adenocarcinoma	EIF3CL	0.04	0.07	lasso	3	0.06	1.9e-07	5.3	5.5	3.0e-08	0.87	0.01	0.99	FALSE
104	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EIF3C	0.01	0.02	blup	10	0.01	1.3e-02	5.5	5.7	1.6e-08	0.85	0.00	0.72	FALSE
105	The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	EIF3CL	0.06	0.09	blup	18	0.09	1.5e-10	5.5	5.5	4.3e-08	0.77	0.01	0.99	FALSE
106	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EIF3C	0.04	0.05	enet	4	0.05	2.9e-04	5.3	5.4	5.3e-08	0.82	0.00	0.97	FALSE
107	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	EIF3CL	0.09	0.09	blup	18	0.09	1.3e-06	5.3	5.3	8.6e-08	0.82	0.01	0.99	FALSE
108	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	EIF3CL	0.11	0.19	lasso	2	0.18	8.3e-08	5.3	5.4	7.9e-08	0.81	0.01	0.99	FALSE
109	The Cancer Genome Atlas	Pancreatic Adenocarcinoma	TUFM	0.13	0.22	enet	5	0.22	1.4e-09	5.3	5.3	1.3e-07	0.81	0.02	0.98	FALSE
110	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	EIF3CL	0.20	0.12	lasso	3	0.18	1.2e-07	5.1	5.5	3.1e-08	0.82	0.01	0.99	FALSE
111	The Cancer Genome Atlas	Prostate Adenocarcinoma	ATP2A1	0.02	0.02	blup	34	0.02	1.5e-03	5.3	5.2	1.9e-07	0.80	0.02	0.92	FALSE
112	The Cancer Genome Atlas	Prostate Adenocarcinoma	EIF3CL	0.08	0.16	lasso	4	0.16	5.5e-17	5.3	5.5	4.1e-08	0.84	0.01	0.99	FALSE
113	The Cancer Genome Atlas	Prostate Adenocarcinoma	SULT1A2	0.05	0.02	lasso	4	0.03	1.0e-03	5.2	5.2	1.5e-07	0.94	0.01	0.98	FALSE
114	The Cancer Genome Atlas	Skin Cutaneous Melanoma	TUFM	0.09	0.08	lasso	4	0.06	1.3e-02	5.3	5.3	9.4e-08	0.81	0.01	0.59	FALSE
115	The Cancer Genome Atlas	Thyroid Carcinoma	EIF3C	0.03	0.04	lasso	2	0.04	5.7e-05	5.3	5.5	3.7e-08	0.80	0.01	0.98	FALSE
116	The Cancer Genome Atlas	Thyroid Carcinoma	EIF3CL	0.10	0.19	blup	18	0.20	5.7e-19	5.3	5.3	1.1e-07	0.86	0.01	0.99	FALSE
117	The Cancer Genome Atlas	Thyroid Carcinoma	TUFM	0.17	0.23	lasso	5	0.23	4.2e-22	5.5	5.2	1.7e-07	0.81	0.01	0.99	FALSE
118	The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	EIF3CL	0.14	0.12	lasso	1	0.10	8.8e-04	5.1	5.1	2.9e-07	0.87	0.01	0.62	FALSE