Hub : Traits :

Suffer from 'nerves'

269 significantly associated models · 43 unique genes.

Significant Loci

# chr p0 p1 # assoc genes # joint genes best TWAS P best SNP P cond SNP P % var exp joint genes
1 2 199443880 201021954 1 1 8.9e-08 2.0e-09 3.8e-03 77 SATB2
2 3 84317575 86808226 1 2 3.7e-11 1.1e-11 7.9e-02 93 CADM2
3 8 8092025 11748645 13 1 2.2e-11 5.1e-10 1.3e-01 94 AF131215.2
4 11 46578400 48559571 12 1 2.9e-17 4.6e-16 5.9e-01 100 NUP160
5 14 74658029 76064624 1 1 1.4e-07 3.7e-08 1.0e-01 91 DLST
6 16 27691641 29595483 13 1 3.7e-09 1.1e-08 8.3e-02 91 SH2B1
7 18 57349900 58729694 1 1 2.2e-08 9.4e-12 8.0e-06 57 MC4R
8 20 17870542 19441650 1 1 6.4e-08 5.6e-08 1.0e+00 100 DTD1

Pleiotropic Associations

Trait chisq ratio # genes+ # genes++ % genes++ corr corr P genes
Depressed Affect (Nagel 2018) 6.3 2 2 4.4 0.00 1.00000 DLST NUP160
Depression (Nagel 2018) 2.3 1 0 0.0 0.00 1.00000 NUP160
Intelligence (Savage-Jansen 2018) 6.2 2 2 4.4 0.00 1.00000 NUP160 SH2B1
Neuroticism (Nagel 2018) 10.0 5 2 4.4 0.96 0.00220 CADM2 DLST DTD1 MC4R NUP160
Worry (Nagel 2018) 17.5 6 5 11.1 0.98 0.00018 CADM2 DLST DTD1 MC4R NUP160 SATB2
Alzheimer’s Disease (including proxy) 2.0 1 0 0.0 0.00 1.00000 NUP160
Crohns Disease (2017) 3.5 1 1 2.2 0.00 1.00000 SH2B1
Irritable Bowel Disease (IBD) 5.5 2 2 4.4 0.00 1.00000 SATB2 SH2B1
Ulcerative Colitis (UC) 5.9 3 1 2.2 0.00 1.00000 CADM2 SATB2 SH2B1
Verbal and Numeric Reasoning (VNR) 5.0 2 1 2.2 0.00 1.00000 NUP160 SH2B1
Body Mass Index (BMI) (2010) 8.4 2 2 4.4 0.00 1.00000 MC4R NUP160
HDL Cholesterol 3.4 1 1 2.2 0.00 1.00000 NUP160
Lupus 2.0 1 0 0.0 0.00 1.00000 AF131215.2
Neuroticism (2016) 10.9 2 2 4.4 0.00 1.00000 AF131215.2 NUP160
Triglycerides 2.9 1 0 0.0 0.00 1.00000 AF131215.2
Type 2 Diabetes (T2D) (2012) 3.4 1 0 0.0 0.00 1.00000 MC4R
Ulcerative Colitis 3.2 1 0 0.0 0.00 1.00000 SATB2
Blood Platelet Count 1.3 2 2 4.4 0.00 1.00000 DLST NUP160
Blood Red Count 1.4 1 1 2.2 0.00 1.00000 SH2B1
Blood White Count 1.7 1 1 2.2 0.00 1.00000 NUP160
Heel T-Score 1.4 3 1 2.2 0.00 1.00000 DLST DTD1 SATB2
BMI 11.7 4 4 8.9 -0.67 0.21722 CADM2 MC4R NUP160 SH2B1
Height 1.3 2 2 4.4 0.00 1.00000 MC4R NUP160
Systolic Blood Pressure 3.7 2 2 4.4 0.00 1.00000 CADM2 NUP160
Smoking Status 6.6 2 1 2.2 0.00 1.00000 CADM2 NUP160
Allergy or Eczema 1.9 1 0 0.0 0.00 1.00000 SH2B1
Lung FEV1/FVC ratio 1.5 1 1 2.2 0.00 1.00000 DLST
Lung FVC 1.2 2 0 0.0 0.00 1.00000 SATB2 SH2B1
Neuroticism 10.0 5 4 8.9 0.96 0.00215 CADM2 DLST DTD1 MC4R NUP160
Tanning 1.5 2 1 2.2 0.00 1.00000 CADM2 NUP160
Hand grip strength (left) 6.0 2 2 4.4 0.00 1.00000 CADM2 NUP160
Number of treatments/medications taken 3.6 1 1 2.2 0.00 1.00000 DLST
Sensitivity / hurt feelings 4.3 1 1 2.2 0.00 1.00000 AF131215.2
Frequency of depressed mood in last 2 weeks 3.8 1 0 0.0 0.00 1.00000 NUP160
Hearing difficulty/problems: Yes 1.7 1 0 0.0 0.00 1.00000 SATB2
Relative age of first facial hair 1.8 1 0 0.0 0.00 1.00000 SATB2
Systolic blood pressure, automated reading 3.1 1 1 2.2 0.00 1.00000 AF131215.2
Medication: Metformin 3.3 1 0 0.0 0.00 1.00000 NUP160
Pack years adult smoking proportion 2.7 1 0 0.0 0.00 1.00000 SH2B1
Impedance of leg (right) 8.5 5 4 8.9 0.80 0.05697 AF131215.2 CADM2 MC4R NUP160 SH2B1
Leg fat-free mass (left) 8.8 4 4 8.9 -0.71 0.18059 AF131215.2 CADM2 MC4R SH2B1
Trunk fat percentage 9.9 3 3 6.7 0.00 1.00000 MC4R NUP160 SH2B1
Hand grip strength (right) 4.4 3 1 2.2 0.00 1.00000 CADM2 NUP160 SH2B1
Current tobacco smoking 3.8 1 0 0.0 0.00 1.00000 NUP160
Fed-up feelings 7.0 3 2 4.4 0.00 1.00000 AF131215.2 DLST SH2B1
Relative age voice broke 2.2 1 0 0.0 0.00 1.00000 SATB2
Taking other prescription medications 4.5 1 0 0.0 0.00 1.00000 DLST
Age when periods started (menarche) 7.2 2 2 4.4 0.00 1.00000 NUP160 SATB2
Heel bone mineral density (BMD) T-score, automated (left) 5.3 1 1 2.2 0.00 1.00000 AF131215.2
High blood pressure 2.6 1 1 2.2 0.00 1.00000 AF131215.2
Sitting height 1.9 1 1 2.2 0.00 1.00000 NUP160
Body mass index (BMI) 12.4 5 5 11.1 -0.66 0.15008 AF131215.2 CADM2 MC4R NUP160 SH2B1
Impedance of leg (left) 8.4 6 4 8.9 0.79 0.03627 AF131215.2 CADM2 DLST MC4R NUP160 SH2B1
Leg predicted mass (left) 8.8 4 4 8.9 -0.71 0.18242 AF131215.2 CADM2 MC4R SH2B1
Trunk fat mass 10.2 4 3 6.7 -0.53 0.35340 CADM2 MC4R NUP160 SH2B1
Waist circumference 11.3 4 4 8.9 -0.58 0.30388 CADM2 MC4R NUP160 SH2B1
Past tobacco smoking 8.6 2 1 2.2 0.00 1.00000 CADM2 DLST
Alcohol usually taken with meals 2.8 1 0 0.0 0.00 1.00000 SH2B1
Nervous feelings 18.8 6 2 4.4 0.93 0.00232 AF131215.2 CADM2 DLST DTD1 NUP160 SATB2
Frequency of tenseness / restlessness in last 2 weeks 3.4 1 0 0.0 0.00 1.00000 NUP160
Forced vital capacity (FVC) 2.0 2 1 2.2 0.00 1.00000 NUP160 SATB2
Heel bone mineral density (BMD) T-score, automated (right) 5.3 1 1 2.2 0.00 1.00000 AF131215.2
Qualifications: None of the above 2.7 1 1 2.2 0.00 1.00000 SH2B1
Fluid intelligence score 4.8 2 2 4.4 0.00 1.00000 NUP160 SH2B1
Neuroticism score 15.0 6 3 6.7 0.92 0.00291 AF131215.2 CADM2 DLST DTD1 MC4R NUP160
Weight 10.1 5 4 8.9 -0.66 0.15792 AF131215.2 CADM2 MC4R NUP160 SH2B1
Impedance of arm (right) 8.4 4 3 6.7 0.98 0.00360 AF131215.2 CADM2 MC4R SATB2
Arm fat percentage (right) 12.2 5 4 8.9 -0.52 0.29100 AF131215.2 CADM2 MC4R NUP160 SH2B1
Trunk fat-free mass 6.6 5 2 4.4 -0.65 0.16058 AF131215.2 CADM2 MC4R NUP160 SH2B1
Hip circumference 10.1 5 4 8.9 -0.59 0.21835 AF131215.2 CADM2 MC4R NUP160 SH2B1
Worrier / anxious feelings 19.0 6 3 6.7 0.97 0.00021 AF131215.2 CADM2 DLST DTD1 MC4R SATB2
Number of live births 3.2 1 0 0.0 0.00 1.00000 CADM2
Forced expiratory volume in 1-second (FEV1) 2.3 2 0 0.0 0.00 1.00000 AF131215.2 NUP160
Happiness 2.9 1 0 0.0 0.00 1.00000 DLST
Qualifications: A levels/AS levels or equivalent 2.3 1 0 0.0 0.00 1.00000 SH2B1
Serious illness, injury or assault of a close relative in last 2 years 3.5 1 0 0.0 0.00 1.00000 SH2B1
Mouth/teeth dental problems: Dentures 2.1 1 0 0.0 0.00 1.00000 AF131215.2
Forced expiratory volume in 1-second (FEV1), Best measure 2.5 3 0 0.0 0.00 1.00000 AF131215.2 NUP160 SATB2
Impedance of arm (left) 8.6 4 3 6.7 0.98 0.00382 AF131215.2 CADM2 MC4R SATB2
Arm fat mass (right) 12.3 5 5 11.1 -0.61 0.19735 AF131215.2 CADM2 MC4R NUP160 SH2B1
Trunk predicted mass 6.5 5 2 4.4 -0.66 0.15727 AF131215.2 CADM2 MC4R NUP160 SH2B1
Standing height 2.1 4 2 4.4 0.22 0.78359 AF131215.2 MC4R NUP160 SH2B1
Tense / 'highly strung' 11.2 3 2 4.4 0.99 0.01192 AF131215.2 CADM2 DTD1
Birth weight of first child 1.9 1 0 0.0 0.00 1.00000 SH2B1
Peak expiratory flow (PEF) 2.6 2 0 0.0 0.00 1.00000 AF131215.2 NUP160
Birth weight 2.0 1 0 0.0 0.00 1.00000 NUP160
Forced vital capacity (FVC), Best measure 2.1 2 1 2.2 0.00 1.00000 NUP160 SATB2
Body fat percentage 9.9 3 3 6.7 0.00 1.00000 MC4R NUP160 SH2B1
Leg fat percentage (right) 7.6 5 3 6.7 -0.55 0.33335 AF131215.2 CADM2 MC4R NUP160 SH2B1
Arm fat-free mass (right) 7.8 4 4 8.9 -0.82 0.09158 AF131215.2 CADM2 MC4R SH2B1
Comparative body size at age 10 14.6 5 5 11.1 -0.70 0.11940 AF131215.2 CADM2 MC4R NUP160 SH2B1
Worry too long after embarrassment 6.4 1 1 2.2 0.00 1.00000 AF131215.2
Number of children fathered 6.6 1 1 2.2 0.00 1.00000 CADM2
Age at first live birth 3.2 1 0 0.0 0.00 1.00000 AF131215.2
Qualifications: College or University degree 3.0 2 1 2.2 0.00 1.00000 CADM2 SH2B1
Medication for pain relief, constipation, heartburn 2.3 1 0 0.0 0.00 1.00000 DLST
Medication: Blood pressure 2.1 1 0 0.0 0.00 1.00000 AF131215.2
Whole body fat mass 11.0 5 4 8.9 -0.59 0.22148 AF131215.2 CADM2 MC4R NUP160 SH2B1
Leg fat mass (right) 10.9 5 5 11.1 -0.63 0.17575 AF131215.2 CADM2 MC4R NUP160 SH2B1
Arm predicted mass (right) 7.4 4 4 8.9 -0.81 0.09541 AF131215.2 CADM2 MC4R SH2B1
Alcohol intake frequency. 9.6 3 3 6.7 -1.00 0.00159 CADM2 NUP160 SH2B1
Comparative height size at age 10 2.3 3 1 2.2 0.00 1.00000 DLST NUP160 SH2B1
Number of full sisters 4.5 1 0 0.0 0.00 1.00000 CADM2
Overall health rating 2.2 1 0 0.0 0.00 1.00000 AF131215.2
Age at last live birth 5.4 3 0 0.0 0.00 1.00000 AF131215.2 CADM2 DTD1
Hypertension (Self-reported) 2.5 1 1 2.2 0.00 1.00000 AF131215.2
Smoking status: Previous 7.4 1 1 2.2 0.00 1.00000 CADM2
Whole body fat-free mass 7.4 4 4 8.9 -0.79 0.11353 AF131215.2 CADM2 MC4R SH2B1
Leg fat-free mass (right) 8.4 4 4 8.9 -0.72 0.17319 AF131215.2 CADM2 MC4R SH2B1
Arm fat percentage (left) 12.5 5 4 8.9 -0.50 0.39233 AF131215.2 CADM2 MC4R NUP160 SH2B1
Average weekly red wine intake 4.2 1 0 0.0 0.00 1.00000 CADM2
Handedness (chirality/laterality): Left-handed 2.2 1 0 0.0 0.00 1.00000 SH2B1
Mood swings 7.5 3 3 6.7 0.00 1.00000 AF131215.2 DLST NUP160
Loneliness, isolation 5.2 1 1 2.2 0.00 1.00000 NUP160
Mouth/teeth dental problems: Mouth ulcers 2.6 1 0 0.0 0.00 1.00000 CADM2
Smoking status: Current 4.3 2 0 0.0 0.00 1.00000 CADM2 NUP160
Forced expiratory volume in 1-second (FEV1), predicted percentage 2.5 2 0 0.0 0.00 1.00000 AF131215.2 SH2B1
Whole body water mass 7.4 4 4 8.9 -0.79 0.11206 AF131215.2 CADM2 MC4R SH2B1
Leg predicted mass (right) 8.4 4 4 8.9 -0.72 0.17142 AF131215.2 CADM2 MC4R SH2B1
Arm fat mass (left) 12.6 5 5 11.1 -0.62 0.19106 AF131215.2 CADM2 MC4R NUP160 SH2B1
Miserableness 7.6 2 2 4.4 0.00 1.00000 AF131215.2 NUP160
Guilty feelings 6.2 3 2 4.4 0.00 1.00000 AF131215.2 DLST NUP160
Wears glasses or contact lenses 3.2 1 0 0.0 0.00 1.00000 CADM2
Medication: Blood pressure 2.5 1 1 2.2 0.00 1.00000 AF131215.2
Medication: Bendroflumethiazide 2.5 1 0 0.0 0.00 1.00000 AF131215.2
Medication: Paracetamol 1.8 1 0 0.0 0.00 1.00000 SH2B1
Alcohol drinker status: Never 4.9 1 0 0.0 0.00 1.00000 CADM2
Ever smoked 7.6 1 1 2.2 0.00 1.00000 CADM2
Basal metabolic rate 8.1 4 4 8.9 -0.75 0.14692 AF131215.2 CADM2 MC4R SH2B1
Leg fat percentage (left) 8.3 6 3 6.7 -0.54 0.21535 AF131215.2 CADM2 DLST MC4R NUP160 SH2B1
Arm fat-free mass (left) 8.1 4 4 8.9 -0.80 0.10224 AF131215.2 CADM2 MC4R SH2B1
Average weekly beer plus cider intake 4.5 1 0 0.0 0.00 1.00000 CADM2
Irritability 7.1 1 1 2.2 0.00 1.00000 AF131215.2
Risk taking 13.1 2 1 2.2 0.00 1.00000 AF131215.2 CADM2
Diastolic blood pressure, automated reading 2.8 1 1 2.2 0.00 1.00000 AF131215.2
Vascular/heart problems diagnosed by doctor 2.3 1 1 2.2 0.00 1.00000 AF131215.2
Medication: Omeprazole (e.g. Zanprol) 2.5 1 0 0.0 0.00 1.00000 SATB2
Pack years of smoking 2.1 1 0 0.0 0.00 1.00000 SH2B1
Impedance of whole body 8.8 4 3 6.7 0.97 0.00615 AF131215.2 CADM2 MC4R SATB2
Leg fat mass (left) 11.1 5 5 11.1 -0.64 0.17138 AF131215.2 CADM2 MC4R NUP160 SH2B1
Arm predicted mass (left) 8.0 4 4 8.9 -0.80 0.10359 AF131215.2 CADM2 MC4R SH2B1

Associations by panel

study tissue # hits % hits/tests avg chisq
GTEx Adipose Subcutaneous 4 0.115 1.6
GTEx Adipose Visceral Omentum 3 0.147 1.7
GTEx Adrenal Gland 4 0.275 1.6
GTEx Artery Aorta 7 0.235 1.6
GTEx Artery Coronary 2 0.169 1.7
GTEx Artery Tibial 7 0.186 1.6
GTEx Brain Caudate basal ganglia 0 0.000 1.6
GTEx Brain Cerebellar Hemisphere 3 0.201 1.6
GTEx Brain Cerebellum 3 0.151 1.5
GTEx Brain Cortex 3 0.290 1.8
GTEx Brain Frontal Cortex BA9 1 0.108 1.7
GTEx Brain Hippocampus 0 0.000 1.7
GTEx Brain Hypothalamus 1 0.169 1.7
GTEx Brain Nucleus accumbens basal ganglia 0 0.000 1.6
GTEx Brain Putamen basal ganglia 0 0.000 1.7
GTEx Breast Mammary Tissue 8 0.405 1.7
GTEx Breast Mammary Tissue (Male) 1 0.084 1.6
GTEx Breast Mammary Tissue (Female) 6 0.365 1.7
GTEx Cells EBV-transformed lymphocytes 1 0.070 1.6
GTEx Cells Transformed fibroblasts 9 0.214 1.6
GTEx Colon Sigmoid 5 0.342 1.7
GTEx Colon Transverse 6 0.291 1.7
GTEx Esophagus Gastroesophageal Junction 2 0.138 1.6
GTEx Esophagus Mucosa 9 0.271 1.6
GTEx Esophagus Muscularis 8 0.248 1.7
GTEx Heart Atrial Appendage 1 0.063 1.7
GTEx Heart Left Ventricle 6 0.392 1.6
GTEx Liver 1 0.139 2.0
GTEx Lung 5 0.174 1.6
GTEx Muscle Skeletal 6 0.208 1.7
GTEx Nerve Tibial 6 0.139 1.6
GTEx Ovary 5 0.551 1.8
GTEx Pancreas 3 0.184 1.6
GTEx Pituitary 3 0.269 1.7
GTEx Prostate 2 0.240 1.7
GTEx Skin Not Sun Exposed Suprapubic 6 0.244 1.7
GTEx Skin Sun Exposed Lower leg 8 0.220 1.6
GTEx Small Intestine Terminal Ileum 0 0.000 1.9
GTEx Spleen 4 0.283 1.7
GTEx Stomach 4 0.275 1.7
GTEx Testis 5 0.158 1.6
GTEx Thyroid 5 0.125 1.6
GTEx Uterus 2 0.353 1.7
GTEx Vagina 3 0.472 1.7
GTEx Whole Blood 4 0.201 1.7
METSIM Adipose 3 0.065 1.5
NTR Blood 2 0.083 1.6
ROSMAP Brain Pre-frontal Cortex 8 0.182 1.7
YFS Blood 4 0.087 1.5
CommonMind Brain Pre-frontal Cortex 6 0.112 1.5
The Cancer Genome Atlas Bladder Urothelial Carcinoma 4 0.242 1.6
The Cancer Genome Atlas Breast Invasive Carcinoma 7 0.159 1.5
The Cancer Genome Atlas Cervical Squamous Cell Carcinoma 2 0.182 1.4
The Cancer Genome Atlas Colon Adenocarcinoma 7 0.339 1.5
The Cancer Genome Atlas Esophageal Carcinoma 1 0.146 1.6
The Cancer Genome Atlas Glioblastoma Multiforme 1 0.098 1.5
The Cancer Genome Atlas Head and Neck Squamous Cell Carcinoma 6 0.220 1.5
The Cancer Genome Atlas Kidney Renal Clear Cell Carcinoma 4 0.098 1.5
The Cancer Genome Atlas Kidney Renal Papillary Cell Carcinoma 4 0.195 1.6
The Cancer Genome Atlas Brain Lower Grade Glioma 5 0.116 1.5
The Cancer Genome Atlas Liver Hepatocellular Carcinoma 5 0.452 1.5
The Cancer Genome Atlas Lung Adenocarcinoma 4 0.136 1.5
The Cancer Genome Atlas Lung Squamous Cell Carcinoma 3 0.120 1.5
The Cancer Genome Atlas Ovarian Serous Cystadenocarcinoma 2 0.126 1.5
The Cancer Genome Atlas Pancreatic Adenocarcinoma 2 0.120 1.5
The Cancer Genome Atlas Pheochromocytoma and Paraganglioma 2 0.151 1.6
The Cancer Genome Atlas Prostate Adenocarcinoma 5 0.108 1.5
The Cancer Genome Atlas Rectum Adenocarcinoma 0 0.000 1.4
The Cancer Genome Atlas Soft Tissue Sarcoma 0 0.000 1.5
The Cancer Genome Atlas Skin Cutaneous Melanoma 1 0.187 1.6
The Cancer Genome Atlas Stomach Adenocarcinoma 2 0.119 1.5
The Cancer Genome Atlas Testicular Germ Cell Tumors 1 0.078 1.5
The Cancer Genome Atlas Thyroid Carcinoma 5 0.097 1.5
The Cancer Genome Atlas Uterine Corpus Endometrial Carcinoma 1 0.197 1.4