Hub : Traits :

Suffer from 'nerves'

269 significantly associated models · 43 unique genes.

Significant Loci

#	chr	p0	p1	# assoc genes	# joint genes	best TWAS P	best SNP P	cond SNP P	% var exp	joint genes
1	2	199443880	201021954	1	1	8.9e-08	2.0e-09	3.8e-03	77	SATB2
2	3	84317575	86808226	1	2	3.7e-11	1.1e-11	7.9e-02	93	CADM2
3	8	8092025	11748645	13	1	2.2e-11	5.1e-10	1.3e-01	94	AF131215.2
4	11	46578400	48559571	12	1	2.9e-17	4.6e-16	5.9e-01	100	NUP160
5	14	74658029	76064624	1	1	1.4e-07	3.7e-08	1.0e-01	91	DLST
6	16	27691641	29595483	13	1	3.7e-09	1.1e-08	8.3e-02	91	SH2B1
7	18	57349900	58729694	1	1	2.2e-08	9.4e-12	8.0e-06	57	MC4R
8	20	17870542	19441650	1	1	6.4e-08	5.6e-08	1.0e+00	100	DTD1

Pleiotropic Associations

Trait	chisq ratio	# genes⁺	# genes⁺⁺	% genes⁺⁺	corr	corr P	genes
Worrier / anxious feelings	19.0	6	3	6.7	0.97	0.00021	AF131215.2 CADM2 DLST DTD1 MC4R SATB2
Nervous feelings	18.8	6	2	4.4	0.93	0.00232	AF131215.2 CADM2 DLST DTD1 NUP160 SATB2
Worry (Nagel 2018)	17.5	6	5	11.1	0.98	0.00018	CADM2 DLST DTD1 MC4R NUP160 SATB2
Neuroticism score	15.0	6	3	6.7	0.92	0.00291	AF131215.2 CADM2 DLST DTD1 MC4R NUP160
Comparative body size at age 10	14.6	5	5	11.1	-0.70	0.11940	AF131215.2 CADM2 MC4R NUP160 SH2B1
Risk taking	13.1	2	1	2.2	0.00	1.00000	AF131215.2 CADM2
Arm fat mass (left)	12.6	5	5	11.1	-0.62	0.19106	AF131215.2 CADM2 MC4R NUP160 SH2B1
Arm fat percentage (left)	12.5	5	4	8.9	-0.50	0.39233	AF131215.2 CADM2 MC4R NUP160 SH2B1
Body mass index (BMI)	12.4	5	5	11.1	-0.66	0.15008	AF131215.2 CADM2 MC4R NUP160 SH2B1
Arm fat mass (right)	12.3	5	5	11.1	-0.61	0.19735	AF131215.2 CADM2 MC4R NUP160 SH2B1
Arm fat percentage (right)	12.2	5	4	8.9	-0.52	0.29100	AF131215.2 CADM2 MC4R NUP160 SH2B1
BMI	11.7	4	4	8.9	-0.67	0.21722	CADM2 MC4R NUP160 SH2B1
Waist circumference	11.3	4	4	8.9	-0.58	0.30388	CADM2 MC4R NUP160 SH2B1
Tense / 'highly strung'	11.2	3	2	4.4	0.99	0.01192	AF131215.2 CADM2 DTD1
Leg fat mass (left)	11.1	5	5	11.1	-0.64	0.17138	AF131215.2 CADM2 MC4R NUP160 SH2B1
Whole body fat mass	11.0	5	4	8.9	-0.59	0.22148	AF131215.2 CADM2 MC4R NUP160 SH2B1
Neuroticism (2016)	10.9	2	2	4.4	0.00	1.00000	AF131215.2 NUP160
Leg fat mass (right)	10.9	5	5	11.1	-0.63	0.17575	AF131215.2 CADM2 MC4R NUP160 SH2B1
Trunk fat mass	10.2	4	3	6.7	-0.53	0.35340	CADM2 MC4R NUP160 SH2B1
Weight	10.1	5	4	8.9	-0.66	0.15792	AF131215.2 CADM2 MC4R NUP160 SH2B1
Hip circumference	10.1	5	4	8.9	-0.59	0.21835	AF131215.2 CADM2 MC4R NUP160 SH2B1
Neuroticism (Nagel 2018)	10.0	5	2	4.4	0.96	0.00220	CADM2 DLST DTD1 MC4R NUP160
Neuroticism	10.0	5	4	8.9	0.96	0.00215	CADM2 DLST DTD1 MC4R NUP160
Trunk fat percentage	9.9	3	3	6.7	0.00	1.00000	MC4R NUP160 SH2B1
Body fat percentage	9.9	3	3	6.7	0.00	1.00000	MC4R NUP160 SH2B1
Alcohol intake frequency.	9.6	3	3	6.7	-1.00	0.00159	CADM2 NUP160 SH2B1
Leg fat-free mass (left)	8.8	4	4	8.9	-0.71	0.18059	AF131215.2 CADM2 MC4R SH2B1
Leg predicted mass (left)	8.8	4	4	8.9	-0.71	0.18242	AF131215.2 CADM2 MC4R SH2B1
Impedance of whole body	8.8	4	3	6.7	0.97	0.00615	AF131215.2 CADM2 MC4R SATB2
Past tobacco smoking	8.6	2	1	2.2	0.00	1.00000	CADM2 DLST
Impedance of arm (left)	8.6	4	3	6.7	0.98	0.00382	AF131215.2 CADM2 MC4R SATB2
Impedance of leg (right)	8.5	5	4	8.9	0.80	0.05697	AF131215.2 CADM2 MC4R NUP160 SH2B1
Body Mass Index (BMI) (2010)	8.4	2	2	4.4	0.00	1.00000	MC4R NUP160
Impedance of leg (left)	8.4	6	4	8.9	0.79	0.03627	AF131215.2 CADM2 DLST MC4R NUP160 SH2B1
Impedance of arm (right)	8.4	4	3	6.7	0.98	0.00360	AF131215.2 CADM2 MC4R SATB2
Leg fat-free mass (right)	8.4	4	4	8.9	-0.72	0.17319	AF131215.2 CADM2 MC4R SH2B1
Leg predicted mass (right)	8.4	4	4	8.9	-0.72	0.17142	AF131215.2 CADM2 MC4R SH2B1
Leg fat percentage (left)	8.3	6	3	6.7	-0.54	0.21535	AF131215.2 CADM2 DLST MC4R NUP160 SH2B1
Basal metabolic rate	8.1	4	4	8.9	-0.75	0.14692	AF131215.2 CADM2 MC4R SH2B1
Arm fat-free mass (left)	8.1	4	4	8.9	-0.80	0.10224	AF131215.2 CADM2 MC4R SH2B1
Arm predicted mass (left)	8.0	4	4	8.9	-0.80	0.10359	AF131215.2 CADM2 MC4R SH2B1
Arm fat-free mass (right)	7.8	4	4	8.9	-0.82	0.09158	AF131215.2 CADM2 MC4R SH2B1
Leg fat percentage (right)	7.6	5	3	6.7	-0.55	0.33335	AF131215.2 CADM2 MC4R NUP160 SH2B1
Miserableness	7.6	2	2	4.4	0.00	1.00000	AF131215.2 NUP160
Ever smoked	7.6	1	1	2.2	0.00	1.00000	CADM2
Mood swings	7.5	3	3	6.7	0.00	1.00000	AF131215.2 DLST NUP160
Arm predicted mass (right)	7.4	4	4	8.9	-0.81	0.09541	AF131215.2 CADM2 MC4R SH2B1
Smoking status: Previous	7.4	1	1	2.2	0.00	1.00000	CADM2
Whole body fat-free mass	7.4	4	4	8.9	-0.79	0.11353	AF131215.2 CADM2 MC4R SH2B1
Whole body water mass	7.4	4	4	8.9	-0.79	0.11206	AF131215.2 CADM2 MC4R SH2B1
Age when periods started (menarche)	7.2	2	2	4.4	0.00	1.00000	NUP160 SATB2
Irritability	7.1	1	1	2.2	0.00	1.00000	AF131215.2
Fed-up feelings	7.0	3	2	4.4	0.00	1.00000	AF131215.2 DLST SH2B1
Smoking Status	6.6	2	1	2.2	0.00	1.00000	CADM2 NUP160
Trunk fat-free mass	6.6	5	2	4.4	-0.65	0.16058	AF131215.2 CADM2 MC4R NUP160 SH2B1
Number of children fathered	6.6	1	1	2.2	0.00	1.00000	CADM2
Trunk predicted mass	6.5	5	2	4.4	-0.66	0.15727	AF131215.2 CADM2 MC4R NUP160 SH2B1
Worry too long after embarrassment	6.4	1	1	2.2	0.00	1.00000	AF131215.2
Depressed Affect (Nagel 2018)	6.3	2	2	4.4	0.00	1.00000	DLST NUP160
Intelligence (Savage-Jansen 2018)	6.2	2	2	4.4	0.00	1.00000	NUP160 SH2B1
Guilty feelings	6.2	3	2	4.4	0.00	1.00000	AF131215.2 DLST NUP160
Hand grip strength (left)	6.0	2	2	4.4	0.00	1.00000	CADM2 NUP160
Ulcerative Colitis (UC)	5.9	3	1	2.2	0.00	1.00000	CADM2 SATB2 SH2B1
Irritable Bowel Disease (IBD)	5.5	2	2	4.4	0.00	1.00000	SATB2 SH2B1
Age at last live birth	5.4	3	0	0.0	0.00	1.00000	AF131215.2 CADM2 DTD1
Heel bone mineral density (BMD) T-score, automated (left)	5.3	1	1	2.2	0.00	1.00000	AF131215.2
Heel bone mineral density (BMD) T-score, automated (right)	5.3	1	1	2.2	0.00	1.00000	AF131215.2
Loneliness, isolation	5.2	1	1	2.2	0.00	1.00000	NUP160
Verbal and Numeric Reasoning (VNR)	5.0	2	1	2.2	0.00	1.00000	NUP160 SH2B1
Alcohol drinker status: Never	4.9	1	0	0.0	0.00	1.00000	CADM2
Fluid intelligence score	4.8	2	2	4.4	0.00	1.00000	NUP160 SH2B1
Taking other prescription medications	4.5	1	0	0.0	0.00	1.00000	DLST
Number of full sisters	4.5	1	0	0.0	0.00	1.00000	CADM2
Average weekly beer plus cider intake	4.5	1	0	0.0	0.00	1.00000	CADM2
Hand grip strength (right)	4.4	3	1	2.2	0.00	1.00000	CADM2 NUP160 SH2B1
Sensitivity / hurt feelings	4.3	1	1	2.2	0.00	1.00000	AF131215.2
Smoking status: Current	4.3	2	0	0.0	0.00	1.00000	CADM2 NUP160
Average weekly red wine intake	4.2	1	0	0.0	0.00	1.00000	CADM2
Frequency of depressed mood in last 2 weeks	3.8	1	0	0.0	0.00	1.00000	NUP160
Current tobacco smoking	3.8	1	0	0.0	0.00	1.00000	NUP160
Systolic Blood Pressure	3.7	2	2	4.4	0.00	1.00000	CADM2 NUP160
Number of treatments/medications taken	3.6	1	1	2.2	0.00	1.00000	DLST
Crohns Disease (2017)	3.5	1	1	2.2	0.00	1.00000	SH2B1
Serious illness, injury or assault of a close relative in last 2 years	3.5	1	0	0.0	0.00	1.00000	SH2B1
HDL Cholesterol	3.4	1	1	2.2	0.00	1.00000	NUP160
Type 2 Diabetes (T2D) (2012)	3.4	1	0	0.0	0.00	1.00000	MC4R
Frequency of tenseness / restlessness in last 2 weeks	3.4	1	0	0.0	0.00	1.00000	NUP160
Medication: Metformin	3.3	1	0	0.0	0.00	1.00000	NUP160
Ulcerative Colitis	3.2	1	0	0.0	0.00	1.00000	SATB2
Number of live births	3.2	1	0	0.0	0.00	1.00000	CADM2
Age at first live birth	3.2	1	0	0.0	0.00	1.00000	AF131215.2
Wears glasses or contact lenses	3.2	1	0	0.0	0.00	1.00000	CADM2
Systolic blood pressure, automated reading	3.1	1	1	2.2	0.00	1.00000	AF131215.2
Qualifications: College or University degree	3.0	2	1	2.2	0.00	1.00000	CADM2 SH2B1
Triglycerides	2.9	1	0	0.0	0.00	1.00000	AF131215.2
Happiness	2.9	1	0	0.0	0.00	1.00000	DLST
Alcohol usually taken with meals	2.8	1	0	0.0	0.00	1.00000	SH2B1
Diastolic blood pressure, automated reading	2.8	1	1	2.2	0.00	1.00000	AF131215.2
Pack years adult smoking proportion	2.7	1	0	0.0	0.00	1.00000	SH2B1
Qualifications: None of the above	2.7	1	1	2.2	0.00	1.00000	SH2B1
High blood pressure	2.6	1	1	2.2	0.00	1.00000	AF131215.2
Peak expiratory flow (PEF)	2.6	2	0	0.0	0.00	1.00000	AF131215.2 NUP160
Mouth/teeth dental problems: Mouth ulcers	2.6	1	0	0.0	0.00	1.00000	CADM2
Forced expiratory volume in 1-second (FEV1), Best measure	2.5	3	0	0.0	0.00	1.00000	AF131215.2 NUP160 SATB2
Hypertension (Self-reported)	2.5	1	1	2.2	0.00	1.00000	AF131215.2
Forced expiratory volume in 1-second (FEV1), predicted percentage	2.5	2	0	0.0	0.00	1.00000	AF131215.2 SH2B1
Medication: Blood pressure	2.5	1	1	2.2	0.00	1.00000	AF131215.2
Medication: Bendroflumethiazide	2.5	1	0	0.0	0.00	1.00000	AF131215.2
Medication: Omeprazole (e.g. Zanprol)	2.5	1	0	0.0	0.00	1.00000	SATB2
Depression (Nagel 2018)	2.3	1	0	0.0	0.00	1.00000	NUP160
Forced expiratory volume in 1-second (FEV1)	2.3	2	0	0.0	0.00	1.00000	AF131215.2 NUP160
Qualifications: A levels/AS levels or equivalent	2.3	1	0	0.0	0.00	1.00000	SH2B1
Medication for pain relief, constipation, heartburn	2.3	1	0	0.0	0.00	1.00000	DLST
Comparative height size at age 10	2.3	3	1	2.2	0.00	1.00000	DLST NUP160 SH2B1
Vascular/heart problems diagnosed by doctor	2.3	1	1	2.2	0.00	1.00000	AF131215.2
Relative age voice broke	2.2	1	0	0.0	0.00	1.00000	SATB2
Overall health rating	2.2	1	0	0.0	0.00	1.00000	AF131215.2
Handedness (chirality/laterality): Left-handed	2.2	1	0	0.0	0.00	1.00000	SH2B1
Mouth/teeth dental problems: Dentures	2.1	1	0	0.0	0.00	1.00000	AF131215.2
Standing height	2.1	4	2	4.4	0.22	0.78359	AF131215.2 MC4R NUP160 SH2B1
Forced vital capacity (FVC), Best measure	2.1	2	1	2.2	0.00	1.00000	NUP160 SATB2
Medication: Blood pressure	2.1	1	0	0.0	0.00	1.00000	AF131215.2
Pack years of smoking	2.1	1	0	0.0	0.00	1.00000	SH2B1
Alzheimer’s Disease (including proxy)	2.0	1	0	0.0	0.00	1.00000	NUP160
Lupus	2.0	1	0	0.0	0.00	1.00000	AF131215.2
Forced vital capacity (FVC)	2.0	2	1	2.2	0.00	1.00000	NUP160 SATB2
Birth weight	2.0	1	0	0.0	0.00	1.00000	NUP160
Allergy or Eczema	1.9	1	0	0.0	0.00	1.00000	SH2B1
Sitting height	1.9	1	1	2.2	0.00	1.00000	NUP160
Birth weight of first child	1.9	1	0	0.0	0.00	1.00000	SH2B1
Relative age of first facial hair	1.8	1	0	0.0	0.00	1.00000	SATB2
Medication: Paracetamol	1.8	1	0	0.0	0.00	1.00000	SH2B1
Blood White Count	1.7	1	1	2.2	0.00	1.00000	NUP160
Hearing difficulty/problems: Yes	1.7	1	0	0.0	0.00	1.00000	SATB2
Lung FEV1/FVC ratio	1.5	1	1	2.2	0.00	1.00000	DLST
Tanning	1.5	2	1	2.2	0.00	1.00000	CADM2 NUP160
Blood Red Count	1.4	1	1	2.2	0.00	1.00000	SH2B1
Heel T-Score	1.4	3	1	2.2	0.00	1.00000	DLST DTD1 SATB2
Blood Platelet Count	1.3	2	2	4.4	0.00	1.00000	DLST NUP160
Height	1.3	2	2	4.4	0.00	1.00000	MC4R NUP160
Lung FVC	1.2	2	0	0.0	0.00	1.00000	SATB2 SH2B1

Associations by panel

study	tissue	# hits	% hits/tests	avg chisq
GTEx	Liver	1	0.139	2.0
GTEx	Small Intestine Terminal Ileum	0	0.000	1.9
GTEx	Brain Cortex	3	0.290	1.8
GTEx	Ovary	5	0.551	1.8
GTEx	Adipose Visceral Omentum	3	0.147	1.7
GTEx	Artery Coronary	2	0.169	1.7
GTEx	Brain Frontal Cortex BA9	1	0.108	1.7
GTEx	Brain Hippocampus	0	0.000	1.7
GTEx	Brain Hypothalamus	1	0.169	1.7
GTEx	Brain Putamen basal ganglia	0	0.000	1.7
GTEx	Breast Mammary Tissue	8	0.405	1.7
GTEx	Breast Mammary Tissue (Female)	6	0.365	1.7
GTEx	Colon Sigmoid	5	0.342	1.7
GTEx	Colon Transverse	6	0.291	1.7
GTEx	Esophagus Muscularis	8	0.248	1.7
GTEx	Heart Atrial Appendage	1	0.063	1.7
GTEx	Muscle Skeletal	6	0.208	1.7
GTEx	Pituitary	3	0.269	1.7
GTEx	Prostate	2	0.240	1.7
GTEx	Skin Not Sun Exposed Suprapubic	6	0.244	1.7
GTEx	Spleen	4	0.283	1.7
GTEx	Stomach	4	0.275	1.7
GTEx	Uterus	2	0.353	1.7
GTEx	Vagina	3	0.472	1.7
GTEx	Whole Blood	4	0.201	1.7
ROSMAP	Brain Pre-frontal Cortex	8	0.182	1.7
GTEx	Adipose Subcutaneous	4	0.115	1.6
GTEx	Adrenal Gland	4	0.275	1.6
GTEx	Artery Aorta	7	0.235	1.6
GTEx	Artery Tibial	7	0.186	1.6
GTEx	Brain Caudate basal ganglia	0	0.000	1.6
GTEx	Brain Cerebellar Hemisphere	3	0.201	1.6
GTEx	Brain Nucleus accumbens basal ganglia	0	0.000	1.6
GTEx	Breast Mammary Tissue (Male)	1	0.084	1.6
GTEx	Cells EBV-transformed lymphocytes	1	0.070	1.6
GTEx	Cells Transformed fibroblasts	9	0.214	1.6
GTEx	Esophagus Gastroesophageal Junction	2	0.138	1.6
GTEx	Esophagus Mucosa	9	0.271	1.6
GTEx	Heart Left Ventricle	6	0.392	1.6
GTEx	Lung	5	0.174	1.6
GTEx	Nerve Tibial	6	0.139	1.6
GTEx	Pancreas	3	0.184	1.6
GTEx	Skin Sun Exposed Lower leg	8	0.220	1.6
GTEx	Testis	5	0.158	1.6
GTEx	Thyroid	5	0.125	1.6
NTR	Blood	2	0.083	1.6
The Cancer Genome Atlas	Bladder Urothelial Carcinoma	4	0.242	1.6
The Cancer Genome Atlas	Esophageal Carcinoma	1	0.146	1.6
The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	4	0.195	1.6
The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	2	0.151	1.6
The Cancer Genome Atlas	Skin Cutaneous Melanoma	1	0.187	1.6
GTEx	Brain Cerebellum	3	0.151	1.5
METSIM	Adipose	3	0.065	1.5
YFS	Blood	4	0.087	1.5
CommonMind	Brain Pre-frontal Cortex	6	0.112	1.5
The Cancer Genome Atlas	Breast Invasive Carcinoma	7	0.159	1.5
The Cancer Genome Atlas	Colon Adenocarcinoma	7	0.339	1.5
The Cancer Genome Atlas	Glioblastoma Multiforme	1	0.098	1.5
The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	6	0.220	1.5
The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	4	0.098	1.5
The Cancer Genome Atlas	Brain Lower Grade Glioma	5	0.116	1.5
The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	5	0.452	1.5
The Cancer Genome Atlas	Lung Adenocarcinoma	4	0.136	1.5
The Cancer Genome Atlas	Lung Squamous Cell Carcinoma	3	0.120	1.5
The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	2	0.126	1.5
The Cancer Genome Atlas	Pancreatic Adenocarcinoma	2	0.120	1.5
The Cancer Genome Atlas	Prostate Adenocarcinoma	5	0.108	1.5
The Cancer Genome Atlas	Soft Tissue Sarcoma	0	0.000	1.5
The Cancer Genome Atlas	Stomach Adenocarcinoma	2	0.119	1.5
The Cancer Genome Atlas	Testicular Germ Cell Tumors	1	0.078	1.5
The Cancer Genome Atlas	Thyroid Carcinoma	5	0.097	1.5
The Cancer Genome Atlas	Cervical Squamous Cell Carcinoma	2	0.182	1.4
The Cancer Genome Atlas	Rectum Adenocarcinoma	0	0.000	1.4
The Cancer Genome Atlas	Uterine Corpus Endometrial Carcinoma	1	0.197	1.4