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chr11:112,135,760-113,969,669

Best TWAS P=8.08e-16 · Best GWAS P=7.15e-16 conditioned to 1

Associated models

#	Study	Tissue	Gene	h2	eQTL R2	model	# weights	model R2	model R2 P	eQTL GWAS Z	TWAS Z	TWAS P	Top SNP corr	PP3	PP4	joint
1	GTEx	Brain Caudate basal ganglia	RP11-159N11.4	0.32	0.07	lasso	7	0.14	9.7e-05	2.7	5.4	8.3e-08	-0.11	0.47	0.03	FALSE
2	GTEx	Brain Cortex	TTC12	0.48	0.39	lasso	5	0.43	3.2e-13	5.4	5.5	4.1e-08	-0.10	0.96	0.00	FALSE
3	GTEx	Brain Hypothalamus	RP11-159N11.4	0.44	0.06	lasso	19	0.03	7.5e-02	5.4	6.5	1.1e-10	-0.08	0.14	0.06	FALSE
4	GTEx	Breast Mammary Tissue	TTC12	0.46	0.30	lasso	7	0.40	8.1e-22	5.4	6.0	2.0e-09	-0.11	1.00	0.00	FALSE
5	GTEx	Breast Mammary Tissue (Female)	TTC12	0.46	0.22	lasso	10	0.34	6.2e-11	-6.2	5.5	3.5e-08	-0.06	0.96	0.01	FALSE
6	GTEx	Esophagus Gastroesophageal Junction	TTC12	0.67	0.39	enet	34	0.54	4.6e-23	-5.7	5.8	4.9e-09	-0.10	1.00	0.00	FALSE
7	GTEx	Heart Left Ventricle	TTC12	0.39	0.24	enet	36	0.38	2.5e-21	6.9	6.3	2.3e-10	-0.16	0.99	0.01	FALSE
8	GTEx	Muscle Skeletal	TTC12	0.44	0.34	lasso	10	0.40	2.4e-41	-6.1	5.2	2.1e-07	-0.05	1.00	0.00	TRUE
9	GTEx	Skin Not Sun Exposed Suprapubic	TTC12	0.49	0.29	lasso	10	0.51	6.5e-32	5.4	5.4	5.9e-08	-0.12	1.00	0.00	FALSE
10	GTEx	Spleen	RP11-159N11.4	0.30	0.06	lasso	6	0.06	1.4e-02	6.7	5.9	3.9e-09	-0.14	0.14	0.06	FALSE
11	GTEx	Testis	TTC12	0.42	0.16	enet	33	0.38	7.7e-18	6.7	6.9	4.4e-12	-0.41	0.81	0.18	FALSE
12	GTEx	Uterus	NCAM1	0.41	-0.01	lasso	11	-0.01	5.9e-01	5.4	6.4	1.5e-10	-0.22	0.08	0.07	TRUE
13	METSIM	Adipose	ANKK1	0.16	0.11	enet	13	0.16	9.8e-23	-4.3	-7.0	2.4e-12	0.28	1.00	0.00	FALSE
14	YFS	Blood	ANKK1	0.04	0.03	lasso	3	0.03	2.9e-09	-4.5	-5.6	2.3e-08	0.24	1.00	0.00	FALSE
15	The Cancer Genome Atlas	Breast Invasive Carcinoma	TTC12	0.19	0.12	blup	48	0.15	1.1e-28	6.9	5.2	2.0e-07	-0.10	0.00	1.00	FALSE
16	The Cancer Genome Atlas	Head and Neck Squamous Cell Carcinoma	ANKK1	0.04	0.02	blup	66	0.03	5.0e-04	6.7	7.8	6.7e-15	-0.32	0.20	0.27	FALSE
17	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	ANKK1	0.04	0.03	blup	67	0.04	6.3e-05	6.4	-7.3	3.1e-13	0.39	0.46	0.31	TRUE
18	The Cancer Genome Atlas	Kidney Renal Clear Cell Carcinoma	TTC12	0.49	0.30	enet	22	0.40	3.2e-48	6.9	5.1	2.8e-07	-0.04	0.00	1.00	TRUE
19	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	DRD2	0.13	0.05	blup	97	0.07	5.7e-05	4.1	5.4	7.6e-08	-0.61	0.17	0.51	FALSE
20	The Cancer Genome Atlas	Kidney Renal Papillary Cell Carcinoma	TTC12	0.37	0.22	enet	5	0.22	1.1e-12	5.8	5.5	3.6e-08	-0.13	0.05	0.95	FALSE
21	The Cancer Genome Atlas	Brain Lower Grade Glioma	TTC12	0.33	0.28	blup	48	0.30	1.4e-34	6.9	5.5	4.4e-08	-0.15	0.00	1.00	FALSE
22	The Cancer Genome Atlas	Liver Hepatocellular Carcinoma	ANKK1	0.08	0.02	blup	66	0.04	5.6e-03	5.8	-6.5	7.9e-11	0.16	0.18	0.09	FALSE
23	The Cancer Genome Atlas	Lung Adenocarcinoma	DRD2	0.06	0.07	lasso	2	0.07	6.6e-09	-8.0	8.1	8.1e-16	-1.00	0.00	1.00	TRUE
24	The Cancer Genome Atlas	Ovarian Serous Cystadenocarcinoma	TTC12	0.25	0.12	blup	48	0.12	2.4e-08	5.8	5.6	2.7e-08	-0.15	0.11	0.89	FALSE
25	The Cancer Genome Atlas	Pheochromocytoma and Paraganglioma	TTC12	0.36	0.30	lasso	3	0.29	6.0e-12	6.9	6.9	5.7e-12	-0.22	0.01	0.99	FALSE
26	The Cancer Genome Atlas	Prostate Adenocarcinoma	TTC12	0.21	0.20	lasso	4	0.22	1.2e-22	6.9	6.5	5.6e-11	-0.19	0.01	0.99	TRUE
27	The Cancer Genome Atlas	Stomach Adenocarcinoma	TTC12	0.25	0.10	enet	10	0.17	3.6e-12	5.8	5.3	1.3e-07	-0.10	0.02	0.98	FALSE
28	The Cancer Genome Atlas	Testicular Germ Cell Tumors	TTC12	0.07	0.06	blup	48	0.04	1.6e-02	5.8	7.3	2.4e-13	-0.25	0.01	0.73	FALSE
29	The Cancer Genome Atlas	Thyroid Carcinoma	TTC12	0.73	0.41	enet	24	0.51	3.9e-57	5.8	5.4	8.5e-08	-0.04	0.62	0.38	FALSE