Best TWAS P=7.35e-16 · Best GWAS P=1.51e-14 conditioned to 0.103
| # | Study | Tissue | Gene | h2 | eQTL R2 | model | # weights | model R2 | model R2 P | eQTL GWAS Z | TWAS Z | TWAS P | Top SNP corr | PP3 | PP4 | joint |
|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|---|
| 1 | CommonMind | Brain Pre-frontal Cortex | DCXR | 0.14 | 0.07 | enet | 17 | 0.10 | 3.4e-12 | 3.4 | 6.4 | 1.7e-10 | -0.43 | 1.00 | 0.00 | FALSE |
| 2 | CommonMind | Brain Pre-frontal Cortex | LRRC45 | 0.09 | 0.10 | enet | 7 | 0.10 | 1.2e-11 | -6.9 | 6.7 | 2.7e-11 | -0.73 | 0.41 | 0.59 | FALSE |
| 3 | CommonMind | Brain Pre-frontal Cortex | MYADML2 | 0.52 | 0.43 | enet | 15 | 0.45 | 3.6e-60 | -6.3 | -6.3 | 3.3e-10 | 0.59 | 0.97 | 0.03 | FALSE |
| 4 | GTEx | Adipose Subcutaneous | LRRC45 | 0.23 | 0.06 | lasso | 3 | 0.05 | 1.0e-04 | -6.9 | 7.3 | 3.6e-13 | -0.75 | 0.27 | 0.68 | FALSE |
| 5 | GTEx | Adipose Visceral Omentum | LRRC45 | 0.18 | 0.03 | enet | 12 | 0.10 | 9.0e-06 | -6.8 | 6.0 | 1.7e-09 | -0.75 | 0.42 | 0.52 | FALSE |
| 6 | GTEx | Artery Tibial | LRRC45 | 0.09 | 0.07 | lasso | 4 | 0.04 | 2.0e-04 | -6.9 | 7.3 | 3.6e-13 | -0.76 | 0.28 | 0.66 | FALSE |
| 7 | GTEx | Cells Transformed fibroblasts | LRRC45 | 0.08 | 0.08 | enet | 3 | 0.08 | 2.6e-06 | -6.9 | 7.2 | 7.8e-13 | -0.81 | 0.17 | 0.82 | FALSE |
| 8 | GTEx | Esophagus Muscularis | DCXR | 0.18 | 0.08 | lasso | 5 | 0.05 | 9.2e-04 | 3.9 | 5.2 | 2.2e-07 | -0.30 | 0.62 | 0.12 | FALSE |
| 9 | GTEx | Heart Atrial Appendage | LRRC45 | 0.19 | 0.06 | enet | 9 | 0.12 | 6.7e-06 | -6.0 | 7.2 | 4.8e-13 | -0.79 | 0.30 | 0.60 | FALSE |
| 10 | GTEx | Skin Not Sun Exposed Suprapubic | DCXR | 0.12 | 0.00 | enet | 13 | 0.00 | 2.3e-01 | 3.6 | 5.6 | 2.3e-08 | -0.42 | 0.08 | 0.15 | FALSE |
| 11 | GTEx | Thyroid | ASPSCR1 | 0.23 | 0.15 | enet | 19 | 0.09 | 1.2e-07 | -6.4 | 7.0 | 2.0e-12 | -0.74 | 0.74 | 0.26 | FALSE |
| 12 | YFS | Blood | ASPSCR1 | 0.11 | 0.07 | lasso | 9 | 0.06 | 7.9e-20 | -7.6 | 8.1 | 7.4e-16 | -0.85 | 0.00 | 1.00 | TRUE |
| 13 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | LRRC45 | 0.02 | 0.03 | blup | 36 | 0.02 | 1.5e-03 | -6.9 | 7.0 | 2.3e-12 | -0.80 | 0.02 | 0.62 | FALSE |
| 14 | The Cancer Genome Atlas | Head and Neck Squamous Cell Carcinoma | PYCR1 | 0.02 | 0.01 | blup | 9 | 0.01 | 1.1e-02 | -6.3 | 6.9 | 6.0e-12 | -0.68 | 0.00 | 0.66 | FALSE |
| 15 | The Cancer Genome Atlas | Kidney Renal Clear Cell Carcinoma | STRA13 | 0.05 | 0.04 | blup | 33 | 0.05 | 5.0e-06 | -6.9 | 5.2 | 1.8e-07 | -0.72 | 0.18 | 0.82 | FALSE |
| 16 | The Cancer Genome Atlas | Brain Lower Grade Glioma | LRRC45 | 0.05 | 0.07 | lasso | 6 | 0.06 | 9.5e-08 | -6.9 | 6.9 | 5.5e-12 | -0.81 | 0.08 | 0.92 | FALSE |
| 17 | The Cancer Genome Atlas | Brain Lower Grade Glioma | MYADML2 | 0.03 | 0.03 | blup | 10 | 0.03 | 1.1e-04 | -6.8 | -6.8 | 1.2e-11 | 0.69 | 0.02 | 0.89 | FALSE |
| 18 | The Cancer Genome Atlas | Brain Lower Grade Glioma | NOTUM | 0.06 | 0.02 | enet | 2 | 0.02 | 4.7e-03 | -5.2 | -6.4 | 1.2e-10 | 0.63 | 0.01 | 0.56 | FALSE |
| 19 | The Cancer Genome Atlas | Lung Adenocarcinoma | NPB | 0.03 | 0.01 | enet | 3 | 0.01 | 1.1e-02 | -6.2 | 5.8 | 9.0e-09 | -0.64 | 0.00 | 0.69 | FALSE |
| 20 | The Cancer Genome Atlas | Pheochromocytoma and Paraganglioma | LRRC45 | 0.10 | 0.02 | blup | 35 | 0.04 | 8.0e-03 | -5.1 | 7.2 | 8.9e-13 | -0.76 | 0.01 | 0.43 | FALSE |
| 21 | The Cancer Genome Atlas | Prostate Adenocarcinoma | STRA13 | 0.05 | 0.03 | lasso | 3 | 0.02 | 1.8e-03 | -6.9 | 6.9 | 4.4e-12 | -0.75 | 0.08 | 0.46 | FALSE |
| 22 | The Cancer Genome Atlas | Thyroid Carcinoma | DCXR | 0.09 | 0.03 | blup | 38 | 0.09 | 9.5e-09 | 3.6 | 6.4 | 1.5e-10 | -0.49 | 0.27 | 0.72 | FALSE |