Hub : Genes

SOGA2

Models

# panel tissue h2 h2 se h2 P eQTL R2 BLUP R2 ENET R2 BSLMM R2 LASSO R2 eQTL P BLUP P ENET P BSLMM P LASSO P
1 GTEx Lung 0.1430 0.0476 0.00230 0.092 NA 0.068 NA 0.079 1.7e-07 NA 6.2e-06 NA 1.2e-06
2 GTEx Nerve Tibial 0.1723 0.0605 0.00630 0.076 NA 0.027 NA 0.051 4.8e-06 NA 4.9e-03 NA 1.5e-04
3 GTEx Pancreas 0.2100 0.0770 0.00940 -0.006 NA -0.003 NA -0.005 6.7e-01 NA 4.6e-01 NA 6.2e-01
4 GTEx Testis 0.2690 0.0660 0.00011 0.152 NA 0.169 NA 0.171 2.9e-07 NA 5.8e-08 NA 5.1e-08
5 ROSMAP Brain Pre-frontal Cortex 0.0862 0.0254 0.00042 0.044 0.023 0.034 0.03 0.044 2.5e-06 0.00045 2.9e-05 8.3e-05 2.1e-06

Trait associations

Trait Avg chi2 ratio Avg chi2 Max chi2 1 2 3 4 5
Bipolar Disorder (2018) 0.4 0.6 0.9 0.8 -1.0 0.0 -0.6 -0.9
Bipolar Disorder or Schizophrenia 0.1 0.1 0.5 -0.2 0.2 0.0 0.7 0.3
Depressed Affect (Nagel 2018) 0.4 0.8 2.3 -0.2 0.7 0.0 1.5 1.0
Depression (Nagel 2018) 0.5 0.8 1.6 -0.6 1.0 0.0 1.0 1.3
Intelligence (Savage-Jansen 2018) 0.1 0.3 0.8 0.9 -0.4 0.0 -0.1 -0.5
Neuroticism (Nagel 2018) 0.0 0.1 0.2 0.3 -0.4 0.0 0.4 -0.3
Schizophrenia (2018) 0.5 1.0 2.1 -0.9 1.0 0.0 1.4 1.2
Schizophrenia vs Biploar Disorder 1.7 2.3 3.3 -1.8 1.8 0.0 1.4 1.8
Worry (Nagel 2018) 0.1 0.3 0.8 0.4 -0.6 0.0 -0.5 -0.9
Alzheimer’s Disease (in mother) 0.3 0.4 1.2 1.1 0.6 0.0 0.1 0.5
Alzheimer’s Disease (in father) 4.9 5.3 9.7 2.0 -3.1 0.0 -1.9 -3.0
Alzheimer’s Disease (including proxy) 1.0 1.5 3.5 1.9 -1.1 0.0 -1.1 -1.2
Crohns Disease (2017) 0.4 0.8 2.1 0.7 -0.7 0.0 -1.4 -1.0
Irritable Bowel Disease (IBD) 0.5 1.2 3.1 0.6 -1.0 0.0 -1.8 -1.3
Ulcerative Colitis (UC) 0.4 0.7 1.9 0.4 -0.9 0.0 -1.4 -0.9
Major Depression (MDD) 0.0 0.0 0.0 0.2 -0.2 0.0 0.1 0.2
Reaction Time 0.2 0.4 1.1 1.0 -0.2 0.0 -0.6 -0.7
Verbal and Numeric Reasoning (VNR) 0.3 0.8 1.8 1.3 -0.8 0.0 -0.7 -0.9
Breast Cancer 0.1 0.3 0.7 -0.4 0.5 0.0 0.9 0.6
Ovarian Cancer 0.0 0.0 0.0 0.1 0.2 0.0 0.0 -0.2
Prostate Cancer 0.8 1.1 4.0 2.0 -0.6 0.0 -0.7 -0.8
Age at First Birth 0.2 0.3 0.6 0.8 -0.5 0.0 0.1 -0.6
Bipolar Disorder (2011) 0.9 0.9 2.2 -0.5 1.2 0.0 1.5 0.8
Body Mass Index (BMI) (2010) 0.6 0.8 1.6 -0.4 1.2 0.0 0.8 1.3
Coronary Artery Disease (CAD) 0.4 0.5 1.2 0.9 -0.4 0.0 -1.1 -0.6
Crohns Disease (2012) 0.2 0.3 1.1 0.5 0.5 0.0 -1.0 -0.3
Mean Putamen Volume 1.3 1.5 2.7 1.6 -1.3 0.0 -1.3 -1.1
Fasting Glucose 1.3 1.6 2.8 -1.7 1.1 0.0 1.4 1.4
HbA1C 0.3 0.3 0.6 0.4 0.4 0.0 0.8 0.7
HDL Cholesterol 0.3 0.5 1.2 0.4 -0.7 0.0 -0.9 -1.1
LDL Cholesterol 0.1 0.2 0.3 -0.4 0.3 0.0 0.6 0.4
Lupus 0.0 0.0 0.2 -0.1 -0.4 0.0 0.2 -0.0
Neuroticism (2016) 0.1 0.2 0.4 -0.2 0.6 0.0 0.5 0.6
Primary Biliary Cirrhosis 0.4 0.6 1.5 0.6 -0.4 0.0 -1.2 -1.0
Rheumatoid Arthritis 0.5 0.7 1.2 -0.8 0.8 0.0 1.1 1.1
Schizophrenia (2014) 0.7 1.5 3.1 -1.8 0.9 0.0 1.5 1.3
Triglycerides 0.5 0.9 1.8 -1.1 0.8 0.0 1.3 0.8
Type 2 Diabetes (T2D) (2012) 1.1 1.2 2.1 1.5 -1.0 0.0 -1.1 -1.3
Ulcerative Colitis 1.2 1.7 4.0 0.7 -1.3 0.0 -2.0 -1.6
Blood Eosinophil Count 0.1 0.5 1.0 -0.7 0.7 0.0 1.0 0.8
Blood Platelet Count 0.4 5.1 8.1 2.8 -2.5 0.0 -2.1 -2.6
Blood Red Count 0.1 1.1 1.9 -0.8 1.2 0.0 1.2 1.4
Blood White Count 0.1 1.0 1.8 -1.0 1.3 0.0 0.9 1.2
Heel T-Score 0.5 4.2 6.7 -1.9 2.4 0.0 2.2 2.6
BMI 1.2 6.8 11.3 -2.1 3.0 0.0 3.1 3.4
Height 0.1 2.4 5.2 -2.1 0.9 0.0 2.3 1.3
Waist Hip Ratio (WHR) 0.1 0.4 0.8 -0.5 0.7 0.0 0.9 0.5
Systolic Blood Pressure 1.0 5.0 10.4 3.2 -1.9 0.0 -2.0 -2.6
Smoking Status 0.0 0.1 0.2 0.4 0.5 0.0 0.0 0.2
Allergy or Eczema 0.2 0.5 1.0 0.5 -0.6 0.0 -1.0 -0.9
Cardiovascular Disease 0.1 0.2 0.7 0.4 0.5 0.0 -0.9 0.1
Hypothyroidism (self reported) 1.8 4.1 6.7 -1.5 2.6 0.0 2.4 2.5
Respiratory disease 1.9 4.2 6.8 2.6 -2.5 0.0 -1.4 -2.5
Type 2 Diabetes (T2D) (2018) 1.3 2.5 4.0 2.0 -1.7 0.0 -1.7 -1.7
Lung FEV1/FVC ratio 9.1 46.0 74.9 -7.0 8.7 0.0 5.6 8.7
Lung FVC 5.9 30.3 45.6 -6.1 6.6 0.0 5.0 6.8
Neuroticism 0.0 0.1 0.3 0.1 -0.2 0.0 0.5 -0.0
Chronotype (morning person) 0.3 0.6 1.5 0.3 -1.2 0.0 -0.8 -0.9
Hair Pigment 0.0 0.5 1.2 -0.4 -1.1 0.0 -0.7 -0.9
Tanning 0.0 0.2 0.5 0.7 -0.6 0.0 -0.0 -0.3
Hand grip strength (left) 0.9 2.3 3.3 -1.8 1.5 0.0 1.7 1.7
Number of treatments/medications taken 0.1 0.1 0.3 0.6 -0.4 0.0 -0.1 -0.4
Average weekly spirits intake 0.2 0.3 0.7 -0.3 0.6 0.0 0.4 0.8
Sensitivity / hurt feelings 0.9 1.5 3.7 0.2 -1.9 0.0 -1.0 -1.6
Frequency of depressed mood in last 2 weeks 0.8 1.2 1.9 -0.9 1.1 0.0 1.3 1.4
Hearing difficulty/problems: Yes 0.2 0.3 0.6 0.7 -0.7 0.0 -0.5 -0.3
Relative age of first facial hair 0.8 1.7 5.4 -2.3 1.3 0.0 0.5 1.0
Other serious medical condition/disability diagnosed by doctor 0.1 0.2 0.4 -0.7 0.5 0.0 -0.1 0.5
Ever used hormone-replacement therapy (HRT) 3.9 5.0 6.9 -2.3 2.6 0.0 2.5 2.5
Ever had hysterectomy (womb removed) 1.6 1.8 3.4 -1.6 1.8 0.0 1.1 1.4
Systolic blood pressure, automated reading 0.1 0.2 0.5 0.7 -0.2 0.0 0.5 -0.5
Eye problems/disorders: Diabetes related eye disease 1.0 1.0 1.9 1.4 -0.8 0.0 -1.2 -1.1
Angina 0.2 0.2 0.9 0.5 -0.1 0.0 -1.0 -0.1
Medication for hormone replacement therapy 0.3 0.3 0.8 -0.9 0.1 0.0 0.9 0.0
Vitamin and mineral supplements 0.6 0.9 1.7 -0.8 1.3 0.0 0.7 1.2
Supplements: Zinc 0.1 0.1 0.3 -0.6 -0.2 0.0 0.5 -0.1
Medication: Co-codamol 0.3 0.4 1.3 0.7 0.3 0.0 -1.1 0.1
Medication: Metformin 0.2 0.3 0.5 0.7 -0.7 0.0 -0.4 -0.4
Diabetes (father) 0.3 0.4 1.0 0.6 0.6 0.0 0.6 1.0
Diabetes (mother) 0.5 0.6 1.0 0.3 -0.9 0.0 -1.0 -1.0
Severe depression (siblings) 0.9 1.0 2.6 -0.8 1.0 0.0 0.8 1.6
Pack years adult smoking proportion 0.6 1.0 3.2 -1.1 -0.1 0.0 1.8 0.5
Impedance of leg (right) 1.4 6.8 12.5 2.3 -3.5 0.0 -2.2 -3.3
Leg fat-free mass (left) 1.3 6.8 10.8 -2.7 2.8 0.0 2.8 3.3
Trunk fat percentage 0.1 0.4 0.8 -0.5 0.5 0.0 0.8 0.9
Hand grip strength (right) 0.3 0.8 1.4 -0.9 1.1 0.0 0.8 1.2
Townsend deprivation index at recruitment 2.8 3.9 6.1 -2.5 2.0 0.0 2.1 2.2
Current tobacco smoking 0.2 0.4 0.8 0.8 -0.2 0.0 -0.9 -0.6
Average weekly fortified wine intake 0.0 0.0 0.1 0.3 -0.1 0.0 -0.0 -0.2
Maternal smoking around birth 2.7 3.9 5.8 -2.4 2.2 0.0 1.8 2.4
Fed-up feelings 1.3 2.3 4.4 -1.3 1.9 0.0 1.5 2.1
Frequency of unenthusiasm / disinterest in last 2 weeks 1.0 1.4 2.8 -0.7 1.6 0.0 0.9 1.7
Relative age voice broke 0.8 1.3 2.8 -1.2 1.7 0.0 0.9 1.1
Taking other prescription medications 0.1 0.1 0.3 0.5 -0.3 0.0 -0.1 -0.5
Age when periods started (menarche) 0.2 0.4 1.3 -1.1 0.1 0.0 0.5 0.5
Bilateral oophorectomy (both ovaries removed) 1.0 1.1 2.1 -1.4 1.2 0.0 1.0 1.0
Heel bone mineral density (BMD) T-score, automated (left) 0.1 0.3 1.1 -1.0 0.0 0.0 0.5 -0.1
Tinnitus: Yes, but not now, but have in the past 0.2 0.2 0.4 0.6 0.6 0.0 0.5 0.3
Qualifications: CSEs or equivalent 0.2 0.3 0.7 0.4 0.5 0.0 0.8 0.5
Serious illness, injury or assault to yourself 0.3 0.4 1.3 -0.2 1.2 0.0 0.0 0.6
High blood pressure 0.0 0.1 0.3 -0.2 0.5 0.0 -0.2 0.5
Hayfever, allergic rhinitis or eczema 0.1 0.3 0.6 0.6 -0.6 0.0 -0.8 -0.5
Multivitamins +/- minerals 0.2 0.2 0.5 0.3 -0.7 0.0 0.5 -0.4
Stomach or abdominal pain in last month 0.0 0.0 0.1 -0.1 -0.1 0.0 0.2 -0.3
Supplements: Glucosamine 0.3 0.4 1.0 -1.0 0.4 0.0 0.7 0.5
Diverticular disease/diverticulitis (self-reported) 3.2 3.9 5.6 -2.4 2.3 0.0 1.9 2.2
Medication: Atenolol 0.2 0.3 0.6 0.8 0.7 0.0 0.1 0.4
Medication: Levothyroxine sodium 2.5 4.3 6.6 -2.1 2.0 0.0 2.6 2.5
Sitting height 0.1 0.8 1.9 -1.1 0.4 0.0 1.4 0.9
Chronic bronchitis/emphysema (father) 0.6 0.7 1.4 0.8 -0.9 0.0 -0.8 -1.2
High blood pressure (mother) 0.2 0.3 0.5 0.3 0.7 0.0 0.6 0.6
Body mass index (BMI) 0.7 2.9 5.9 -1.3 1.8 0.0 1.9 2.4
Impedance of leg (left) 1.9 9.4 15.6 2.9 -4.0 0.0 -2.8 -3.9
Leg predicted mass (left) 1.3 6.7 10.7 -2.7 2.8 0.0 2.7 3.3
Trunk fat mass 0.4 1.7 2.9 -1.2 1.2 0.0 1.7 1.7
Waist circumference 0.6 2.4 4.1 -1.4 1.6 0.0 1.9 2.0
Number of incorrect matches in round 0.1 0.1 0.4 -0.1 -0.6 0.0 -0.3 -0.4
Past tobacco smoking 0.1 0.2 0.4 -0.4 -0.7 0.0 -0.3 -0.3
Alcohol usually taken with meals 0.3 0.5 1.4 1.2 -0.8 0.0 -0.3 -0.7
Nervous feelings 0.3 0.6 1.2 -0.1 -0.9 0.0 -0.9 -1.1
Frequency of tenseness / restlessness in last 2 weeks 2.9 4.6 8.1 -2.6 2.8 0.0 1.6 2.3
Hearing difficulty/problems with background noise 0.2 0.3 0.6 0.4 0.4 0.0 0.7 0.7
Hair/balding pattern: Pattern 2 3.6 4.6 8.8 -2.2 3.0 0.0 1.8 2.4
Had menopause 0.3 0.4 0.8 -0.9 0.9 0.0 0.5 0.5
Had other major operations 0.5 0.6 1.6 -0.5 0.5 0.0 1.3 0.8
Forced vital capacity (FVC) 3.0 11.4 17.3 -3.7 4.1 0.0 3.1 4.2
Heel bone mineral density (BMD) T-score, automated (right) 0.0 0.1 0.2 -0.4 -0.1 0.0 -0.0 -0.4
Ever unenthusiastic/disinterested for a whole week 0.0 0.1 0.2 -0.1 -0.4 0.0 0.1 -0.3
Qualifications: None of the above 0.1 0.1 0.4 -0.5 -0.0 0.0 -0.7 0.1
Financial difficulties in last 2 years 0.2 0.2 0.5 -0.4 0.7 0.0 -0.1 0.6
Mouth/teeth dental problems 0.7 1.0 4.6 2.1 -0.2 0.0 -0.6 -0.4
Heart attack 0.2 0.3 1.2 1.1 -0.3 0.0 0.3 -0.0
Allergy 0.2 0.4 0.8 -0.6 0.9 0.0 0.3 0.8
Pain all over the body in last month 9.9 10.6 17.2 -3.2 3.4 0.0 4.2 3.7
Diabetes (self-reported) 0.8 1.2 3.1 1.7 -1.4 0.0 -0.4 -0.9
Hayfever/allergic rhinitis (self-reported) 0.2 0.3 0.9 0.4 -0.9 0.0 -0.5 -0.5
Medication: Ramipril 0.3 0.4 1.3 1.1 -0.7 0.0 -0.2 -0.4
Medication: Simvastatin 0.3 0.4 1.8 1.3 -0.1 0.0 0.2 -0.0
Fluid intelligence score 0.8 1.6 3.9 -0.2 1.3 0.0 2.0 1.5
Illnesses of siblings 0.0 0.1 0.2 0.4 -0.0 0.0 -0.0 0.3
Neuroticism score 0.1 0.3 0.5 0.7 -0.6 0.0 -0.4 -0.7
Weight 0.8 3.9 6.8 -1.8 2.0 0.0 2.4 2.6
Impedance of arm (right) 1.2 5.8 9.0 2.4 -2.5 0.0 -2.8 -3.0
Arm fat percentage (right) 0.3 1.1 2.5 -0.5 1.2 0.0 1.2 1.6
Trunk fat-free mass 1.4 7.9 12.0 -2.8 3.0 0.0 3.3 3.5
Hip circumference 0.3 1.3 2.8 -0.8 1.1 0.0 1.4 1.7
Time employed in main current job 0.2 0.3 0.7 -0.3 -0.6 0.0 -0.8 -0.4
Alcohol intake versus 10 years previously 0.2 0.3 1.0 -1.0 0.2 0.0 -0.0 0.6
Father’s age at death 0.1 0.1 0.3 -0.1 0.4 0.0 0.6 0.2
Worrier / anxious feelings 1.7 3.3 5.0 2.2 -2.1 0.0 -1.4 -2.2
Frequency of tiredness / lethargy in last 2 weeks 1.1 1.8 3.1 -1.8 1.4 0.0 1.3 1.5
Falls in the last year 0.4 0.6 1.3 -1.1 0.7 0.0 0.7 0.7
Hair/balding pattern: Pattern 3 2.0 2.9 9.2 0.3 -3.0 0.0 -1.1 -2.0
Number of live births 4.5 6.3 11.2 -3.0 3.3 0.0 1.7 2.9
Forced expiratory volume in 1-second (FEV1) 5.9 19.8 31.7 -4.8 5.5 0.0 3.7 5.6
Pulse rate 0.2 0.4 1.5 -1.2 -0.3 0.0 0.5 0.1
Happiness 1.5 1.8 2.9 -1.2 1.6 0.0 1.5 1.7
Noisy workplace 0.3 0.3 0.7 -0.6 0.5 0.0 0.6 0.8
Qualifications: A levels/AS levels or equivalent 0.5 1.2 2.0 0.5 -1.4 0.0 -1.3 -1.4
Serious illness, injury or assault of a close relative in last 2 years 1.3 1.5 2.3 -1.2 1.5 0.0 1.3 1.4
Mouth/teeth dental problems: Dentures 0.4 0.7 1.9 -1.4 0.3 0.0 0.9 0.8
Asthma 2.0 3.9 6.7 2.3 -2.6 0.0 -1.4 -2.4
Medication: Ibuprofen (e.g. Nurofen) 0.2 0.2 0.6 0.4 -0.8 0.0 -0.0 -0.5
Medication: Cholesterol lowering 0.7 1.1 1.5 1.1 -1.2 0.0 -1.2 -1.2
Depression (self-reported) 0.2 0.3 1.1 1.0 -0.5 0.0 0.3 -0.2
Medication: Lansoprazole 0.0 0.0 0.1 0.2 0.1 0.0 -0.3 -0.2
Prospective memory result 1.2 1.4 3.2 -1.0 1.0 0.0 1.8 1.4
Lung cancer (father) 0.1 0.2 0.5 0.4 0.7 0.0 -0.1 0.4
Illnesses of mother 0.2 0.3 0.6 -0.7 0.4 0.0 0.8 0.5
Forced expiratory volume in 1-second (FEV1), Best measure 6.8 21.8 34.4 -5.2 5.7 0.0 3.9 5.9
Pulse wave Arterial Stiffness index 0.4 0.5 1.9 0.1 0.2 0.0 1.4 0.7
Impedance of arm (left) 0.9 4.4 7.1 2.0 -2.1 0.0 -2.5 -2.7
Arm fat mass (right) 0.5 2.1 4.3 -1.0 1.5 0.0 1.6 2.1
Trunk predicted mass 1.4 8.1 12.2 -2.8 3.0 0.0 3.3 3.5
Standing height 0.1 0.8 1.7 -1.2 0.6 0.0 1.3 0.7
Length of working week for main job 0.3 0.3 0.9 -0.1 -1.0 0.0 0.5 -0.6
Exposure to tobacco smoke at home 1.1 1.2 2.7 0.7 -1.0 0.0 -1.4 -1.6
Breastfed as a baby 0.1 0.2 0.5 0.5 -0.1 0.0 -0.4 -0.7
Tense / ‘highly strung’ 0.3 0.4 0.9 0.2 0.9 0.0 0.7 0.9
Seen doctor (GP) for nerves, anxiety, tension or depression 0.6 0.9 2.6 1.6 -0.8 0.0 -0.6 -0.9
Hair/balding pattern: Pattern 4 0.2 0.5 0.9 -0.3 0.8 0.0 0.9 0.9
Birth weight of first child 0.1 0.2 0.6 -0.0 0.4 0.0 0.7 0.3
Peak expiratory flow (PEF) 3.8 8.8 15.8 -3.3 4.0 0.0 2.1 3.7
Pulse wave reflection index 0.2 0.2 0.8 0.9 -0.1 0.0 0.6 -0.1
Ever highly irritable/argumentative for 2 days 0.1 0.1 0.3 -0.1 0.6 0.0 0.1 0.4
Loud music exposure frequency 0.3 0.3 0.7 0.5 -0.5 0.0 -0.8 -0.5
Qualifications: O levels/GCSEs or equivalent 0.2 0.3 1.0 1.0 -0.3 0.0 0.4 -0.4
Mouth/teeth dental problems: Bleeding gums 0.2 0.3 1.5 -1.2 0.3 0.0 -0.1 0.1
Blood clot in the leg (DVT) 6.0 7.8 13.5 -2.8 3.7 0.0 2.4 3.4
Medication: Paracetamol 0.4 0.7 1.5 1.2 -0.4 0.0 -1.2 -0.6
Headache pain in last month 0.8 1.4 3.0 1.2 -0.9 0.0 -1.7 -1.3
Medication for cholesterol, blood pressure or diabetes 0.2 0.3 0.8 -0.4 0.4 0.0 0.9 0.5
Glaucoma (self-reported) 0.1 0.1 0.1 0.4 0.2 0.0 0.2 0.3
Gout (self-reported) 0.6 0.9 1.5 -1.2 0.6 0.0 1.0 1.2
Hypothyroidism/myxoedema (self-reported) 2.1 4.0 6.9 -1.7 2.4 0.0 2.2 2.6
Medication: Amlodipine 0.6 0.9 1.8 -0.2 1.3 0.0 1.1 1.2
Medication: Ventolin 100micrograms inhaler 1.4 1.8 4.0 0.6 -2.0 0.0 -1.0 -1.9
Birth weight 0.6 1.4 3.1 -1.2 1.1 0.0 1.7 1.1
Chronic bronchitis/emphysema (mother) 0.2 0.3 0.6 -0.8 0.7 0.0 -0.2 0.5
High blood pressure (siblings) 0.4 0.5 1.0 -0.5 -0.8 0.0 -0.9 -1.0
Forced vital capacity (FVC), Best measure 3.1 11.3 17.1 -3.9 4.0 0.0 2.9 4.1
Body fat percentage 0.1 0.4 0.7 -0.6 0.3 0.0 0.8 0.8
Leg fat percentage (right) 0.2 0.6 1.8 -0.5 0.2 0.0 1.4 1.0
Arm fat-free mass (right) 1.3 6.9 10.0 -2.9 2.6 0.0 3.1 3.2
Exposure to tobacco smoke outside home 0.2 0.2 0.5 -0.7 -0.1 0.0 0.7 0.5
Comparative body size at age 10 1.4 3.8 6.3 -2.0 2.5 0.0 1.9 2.3
Number of full brothers 0.5 0.6 1.6 -0.1 -0.9 0.0 -1.3 -0.9
Worry too long after embarrassment 0.2 0.3 0.6 -0.2 -0.8 0.0 -0.6 -0.7
Seen a psychiatrist for nerves, anxiety, tension or depression 0.7 1.0 2.0 1.4 -0.7 0.0 -1.3 -0.8
Wheeze or whistling in the chest in last year 0.5 0.9 2.3 0.6 -1.5 0.0 -0.8 -1.1
Number of children fathered 0.1 0.1 0.6 -0.3 0.1 0.0 0.7 -0.1
Reason for reducing amount of alcohol drunk: Health precaution 0.3 0.4 0.8 -0.9 0.2 0.0 0.9 0.5
Age at first live birth 0.3 0.6 2.3 1.5 -0.3 0.0 -0.2 -0.7
Pulse wave peak to peak time 0.5 0.5 2.1 -0.1 -0.2 0.0 -1.5 -0.7
Health satisfaction 1.5 2.0 4.7 -2.2 1.5 0.0 1.0 1.4
Shortness of breath walking on level ground 1.6 1.9 2.7 -1.7 1.5 0.0 1.6 1.5
Qualifications: College or University degree 0.0 0.0 0.0 -0.2 0.1 0.0 0.0 0.1
Eye problems/disorders: None of the above 0.7 0.8 2.1 -1.4 1.2 0.0 -0.5 0.6
Mouth/teeth dental problems: Loose teeth 1.9 2.3 3.4 -1.9 1.8 0.0 1.6 1.5
Emphysema/chronic bronchitis 0.1 0.1 0.6 0.0 -0.1 0.0 0.8 0.0
Medication for pain relief, constipation, heartburn 0.1 0.1 0.6 -0.8 0.1 0.0 -0.0 0.2
Neck or shoulder pain in last month 0.5 0.8 2.1 -1.4 0.8 0.0 -0.0 1.0
Medication: Blood pressure 0.1 0.2 0.4 -0.0 0.7 0.0 -0.2 0.5
Angina (self-reported) 0.2 0.2 0.8 0.6 -0.1 0.0 -0.9 0.0
Migraine (self-reported) 2.4 2.9 5.0 2.2 -1.8 0.0 -2.2 -1.4
Medication: Ibuprofen 0.1 0.1 0.3 0.6 -0.4 0.0 -0.1 -0.4
Medication: Allopurinol 0.3 0.3 1.0 -1.0 0.2 0.0 0.4 0.7
Medication: Omeprazole 0.0 0.0 0.2 0.0 0.2 0.0 -0.4 0.0
Medication: Seretide 50 evohaler 2.1 2.4 8.2 -0.5 1.2 0.0 2.9 1.5
Mean time to correctly identify matches 0.0 0.1 0.5 -0.1 0.7 0.0 -0.0 0.1
Heart disease (mother) 0.3 0.4 1.1 -0.1 -1.1 0.0 -0.6 -0.7
Reproduciblity of spirometry measurement using ERS/ATS criteria 0.3 0.4 0.6 0.4 0.5 0.0 0.8 0.8
Whole body fat mass 0.4 1.6 2.8 -1.2 1.0 0.0 1.6 1.7
Leg fat mass (right) 0.5 1.8 3.7 -1.2 0.8 0.0 1.9 1.7
Arm predicted mass (right) 1.2 5.9 8.8 -2.6 2.4 0.0 2.9 3.0
Pulse rate, automated reading 0.8 2.7 5.4 -2.3 0.7 0.0 2.3 1.6
Alcohol intake frequency. 0.2 0.4 1.7 0.0 0.1 0.0 -1.3 0.5
Comparative height size at age 10 0.1 0.3 0.6 -0.1 0.5 0.0 0.8 0.7
Number of full sisters 0.8 1.0 3.0 -1.7 1.0 0.0 0.2 1.0
Suffer from ‘nerves’ 0.4 0.6 2.0 0.3 -0.9 0.0 -0.6 -1.4
Overall health rating 0.3 0.6 1.3 -0.7 1.1 0.0 0.3 1.2
Chest pain or discomfort 0.0 0.0 0.2 -0.0 -0.4 0.0 -0.1 -0.2
Had major operations 0.3 0.4 1.2 -1.1 0.5 0.0 -0.1 0.6
Age at last live birth 0.2 0.3 0.7 0.0 0.8 0.0 0.5 0.6
Family relationship satisfaction 1.4 1.7 2.6 -1.1 1.5 0.0 1.6 1.5
Leg pain on walking 3.6 4.5 7.2 -1.8 2.7 0.0 2.3 2.6
Qualifications: NVQ or HND or HNC or equivalent 0.1 0.1 0.2 -0.5 -0.0 0.0 0.2 0.3
Commuting to job workplace: Car/motor vehicle 0.2 0.2 0.7 -0.3 0.6 0.0 -0.1 0.9
Illness, injury, bereavement, stress in last 2 years 0.1 0.2 0.5 0.7 -0.5 0.0 0.3 -0.1
Medication: Aspirin 1.0 1.3 2.2 -1.0 1.3 0.0 1.5 1.2
Supplements: Vitamin C 1.2 1.4 2.3 1.1 -1.5 0.0 -1.5 -1.3
Knee pain experienced in last month 0.1 0.2 0.6 -0.8 0.1 0.0 -0.7 0.1
Hypertension (Self-reported) 0.1 0.3 0.6 -0.5 0.8 0.0 -0.3 0.7
Gastro-oesophageal reflux (gord) / gastric reflux (Self-reported) 0.3 0.4 1.5 -0.1 1.2 0.0 0.3 0.6
Illnesses of father: Heart disease 0.1 0.2 0.5 -0.5 0.3 0.0 0.7 0.1
Illnesses of siblings: Diabetes 0.3 0.4 1.4 0.4 1.2 0.0 0.1 0.6
Smoking status: Previous 0.3 0.4 0.9 0.4 1.0 0.0 0.6 0.8
Forced expiratory volume in 1-second (FEV1), predicted 0.1 0.1 0.3 0.2 -0.6 0.0 -0.6 -0.1
Whole body fat-free mass 1.3 7.6 11.8 -2.8 3.0 0.0 3.1 3.4
Leg fat-free mass (right) 1.1 6.0 9.5 -2.5 2.8 0.0 2.5 3.1
Arm fat percentage (left) 0.3 1.4 2.8 -0.8 1.3 0.0 1.3 1.7
Average weekly red wine intake 0.3 0.5 1.8 -0.8 0.1 0.0 1.3 0.3
Handedness (chirality/laterality): Left-handed 1.1 1.4 2.7 1.7 -1.1 0.0 -1.0 -1.4
Mood swings 1.1 2.0 3.0 -1.3 1.6 0.0 1.7 1.7
Loneliness, isolation 0.2 0.2 0.5 0.7 0.6 0.0 0.2 0.4
Long-standing illness, disability or infirmity 0.6 1.0 2.0 -1.0 1.1 0.0 0.9 1.4
Ever had bowel cancer screening 0.6 0.8 1.2 -1.1 0.9 0.0 1.1 0.7
Diabetes diagnosed by doctor 1.0 1.7 3.1 1.7 -1.8 0.0 -1.0 -1.3
Ever had stillbirth, spontaneous miscarriage or termination 1.5 1.6 4.1 -0.7 1.2 0.0 2.0 1.4
Friendships satisfaction 3.4 4.2 6.9 -1.6 2.6 0.0 2.5 2.4
Qualifications: nursing, teaching 0.1 0.2 0.5 0.7 -0.4 0.0 0.4 -0.3
Commuting to job workplace: Walk 1.2 1.2 3.7 -1.2 0.6 0.0 1.9 0.9
Eye problems/disorders: Cataract 0.5 0.6 1.7 0.9 -0.3 0.0 1.3 0.6
Mouth/teeth dental problems: Mouth ulcers 0.2 0.3 0.8 -0.2 -0.9 0.0 -0.2 -0.8
Medication for cholesterol 0.2 0.3 0.9 0.3 -0.7 0.0 -0.9 -0.5
Medication: Laxatives (e.g. Dulcolax, Senokot) 0.2 0.3 0.7 0.5 0.8 0.0 0.1 0.7
Back pain experienced in last month 0.8 1.1 2.6 0.4 -1.3 0.0 -1.0 -1.6
Mineral and other dietary supplements 0.1 0.2 0.5 0.7 0.1 0.0 -0.5 0.0
Breast cancer (self-reported) 1.5 1.7 3.0 0.9 -1.7 0.0 -1.4 -1.7
Asthma (self-reported) 2.1 4.1 6.9 2.3 -2.6 0.0 -1.5 -2.5
Osteoporosis (self-reported) 0.0 0.1 0.2 0.2 0.2 0.0 0.4 -0.0
Osteoarthritis (self-reported) 0.4 0.6 1.3 -1.1 0.9 0.0 -0.1 0.8
Medication: Aspirin 0.4 0.6 1.4 -0.4 0.9 0.0 1.2 0.8
Medication: Gliclazide 0.1 0.2 0.6 0.3 -0.2 0.0 -0.8 -0.2
Illnesses of father: None of the above (group 1) 0.3 0.3 0.9 -0.1 0.9 0.0 0.1 0.9
Smoking status: Current 0.3 0.4 1.0 0.8 -0.3 0.0 -1.0 -0.7
Forced expiratory volume in 1-second (FEV1), predicted percentage 6.4 13.6 23.1 -3.5 4.8 0.0 3.1 4.8
Whole body water mass 1.4 7.8 12.0 -2.8 3.0 0.0 3.1 3.5
Leg predicted mass (right) 1.1 6.1 9.6 -2.6 2.8 0.0 2.6 3.1
Arm fat mass (left) 0.6 2.4 4.8 -1.2 1.6 0.0 1.8 2.2
Number of self-reported non-cancer illnesses 0.2 0.3 0.9 -0.9 0.2 0.0 0.3 0.8
Average weekly champagne plus white wine intake 1.1 1.6 3.1 1.8 -1.2 0.0 -1.3 -1.3
Miserableness 0.1 0.2 0.4 0.4 0.3 0.0 0.6 0.6
Guilty feelings 0.1 0.2 0.4 -0.0 0.4 0.0 0.6 0.6
Wears glasses or contact lenses 0.5 0.5 1.8 -0.1 -0.9 0.0 -0.3 -1.3
Ever taken oral contraceptive pill 0.1 0.1 0.4 -0.7 0.0 0.0 0.0 0.5
Hearing aid user 0.4 0.5 0.7 0.7 -0.7 0.0 -0.8 -0.8
Mother’s age at death 0.3 0.3 0.9 0.0 0.9 0.0 0.7 0.6
Financial situation satisfaction 0.1 0.1 0.3 -0.6 0.1 0.0 0.6 -0.0
Tinnitus: Yes, now most or all of the time 0.8 0.9 1.7 -0.1 1.3 0.0 1.1 1.3
Commuting to job workplace: Public transport 0.1 0.1 0.2 0.3 -0.1 0.0 -0.4 -0.5
Eye problems/disorders: Glaucoma 0.2 0.3 1.0 1.0 -0.3 0.0 0.5 -0.2
Medication: Blood pressure 0.8 1.4 2.6 -0.8 1.6 0.0 1.5 1.3
Pain type(s) experienced in last month: Hip pain 0.4 0.5 0.9 -0.7 0.8 0.0 0.5 1.0
Supplements: Fish oil (including cod liver oil) 0.3 0.4 1.1 0.3 -0.6 0.0 -0.5 -1.0
High cholesterol (Self-reported) 0.3 0.5 1.5 1.2 -0.8 0.0 0.3 -0.7
Medication: Bendroflumethiazide 0.5 0.8 1.3 0.9 -0.9 0.0 -1.1 -1.1
Medication: Paracetamol 0.2 0.3 0.8 0.9 0.3 0.0 -0.6 0.2
Medication: Lisinopril 0.8 1.1 1.8 -1.1 1.1 0.0 1.0 1.4
Medication: Atorvastatin 1.8 2.2 4.6 0.4 -2.2 0.0 -1.4 -2.0
Illnesses of father: High blood pressure 0.1 0.1 0.3 -0.5 0.0 0.0 0.4 -0.1
Alcohol drinker status: Never 2.1 2.5 4.6 2.1 -1.2 0.0 -2.0 -1.5
Ever smoked 0.1 0.2 0.7 0.8 -0.1 0.0 -0.2 -0.5
Basal metabolic rate 1.2 6.8 10.9 -2.6 2.8 0.0 2.9 3.3
Leg fat percentage (left) 0.1 0.5 1.6 -0.3 0.1 0.0 1.3 0.9
Arm fat-free mass (left) 1.2 5.9 8.8 -2.7 2.2 0.0 2.8 3.0
Number of operations (self-reported) 3.6 5.3 8.1 -2.5 2.6 0.0 2.4 2.8
Average weekly beer plus cider intake 4.7 6.8 11.8 -2.7 3.4 0.0 2.1 3.3
Irritability 0.4 0.7 1.4 0.5 0.8 0.0 1.2 1.1
Risk taking 6.7 9.8 14.2 -3.5 3.8 0.0 3.2 3.5
Ever had prostate specific antigen (PSA) test 0.5 0.5 1.3 -0.1 -0.8 0.0 -0.8 -1.2
Fractured/broken bones in last 5 years 0.5 0.6 1.3 0.2 -0.8 0.0 -1.2 -1.1
Age started oral contraceptive pill 0.7 0.9 3.0 -1.7 0.2 0.0 1.1 0.5
Diastolic blood pressure, automated reading 0.1 0.3 0.7 0.1 0.7 0.0 0.8 0.7
Ever depressed for a whole week 1.5 1.8 2.9 1.5 -1.7 0.0 -1.1 -1.7
Unable to work because of sickness or disability 0.1 0.1 0.5 -0.3 0.7 0.0 0.0 0.4
Commuting to job workplace: Cycle 0.2 0.2 1.0 -1.0 -0.0 0.0 0.3 -0.2
Myopia 0.6 0.9 1.8 -0.3 1.3 0.0 0.8 1.3
Vascular/heart problems diagnosed by doctor 0.1 0.2 0.5 0.3 -0.7 0.0 0.0 -0.7
Cholesterol lowering medication 0.1 0.1 0.4 0.0 0.0 0.0 0.6 0.1
Medication: Omeprazole (e.g. Zanprol) 0.2 0.2 0.7 0.5 -0.1 0.0 -0.8 -0.2
Pain experienced in last month 0.2 0.3 0.8 -0.3 0.5 0.0 0.9 0.5
Supplements: Calcium 0.2 0.3 0.5 0.7 -0.7 0.0 -0.2 -0.6
Basal cell carcinoma (self-reported) 5.2 6.1 9.1 -2.7 2.8 0.0 3.0 2.6
Heart attack/myocardial infarction (self-reported) 0.2 0.3 1.3 1.2 -0.1 0.0 0.5 0.1
Deep venous thrombosis (DVT) (self-reported) 4.6 5.9 10.7 -2.3 3.3 0.0 2.1 3.0
Heart disease (siblings) 0.0 0.0 0.0 0.0 0.2 0.0 -0.0 -0.2
Alcohol drinker status: Previous 1.0 1.1 2.2 -1.0 1.5 0.0 0.7 1.4
Pack years of smoking 1.2 1.8 5.3 -1.6 0.4 0.0 2.3 1.0
Impedance of whole body 1.4 7.1 11.6 2.5 -3.1 0.0 -2.8 -3.4
Leg fat mass (left) 0.4 1.5 3.1 -1.1 0.7 0.0 1.8 1.5
Arm predicted mass (left) 1.1 5.8 9.0 -2.6 2.3 0.0 2.9 3.0